SZ12-1

Overview


Name	SZ12-1 (AFD29606.1)
Smed ID	SMED30001977
Length (bp)	2227

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of SZ12-1 (SMED30001977) t-SNE clustered cells

Violin plots show distribution of expression levels for SZ12-1 (SMED30001977) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SZ12-1 (SMED30001977) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SZ12-1 (SMED30001977) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001977

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30001977	SMESG000035646.1	SmedASXL_011791	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30001977	SMESG000035646.1	SmedASXL_011791	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X1 cell	SMED30001977	SMESG000035646.1	SmedASXL_011790	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30001977	SMESG000035646.1	SmedASXL_011790	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30001977	SMESG000035646.1	dd_Smed_v4_9993_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30001977	SMESG000035646.1	dd_Smed_v4_9993_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30001977	SMESG000035646.1	dd_Smed_v4_9993_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30001977	SMESG000035646.1	isotig19342	be_Smed_v2	PMID:22543868 Onal et al., 2012
tail stripe	SMED30001977	SMESG000035646.1	isotig19342	be_Smed_v2	PMID:22543868 Onal et al., 2012
parenchyma	SMED30001977	SMESG000035646.1	isotig23175	be_Smed_v2	PMID:22543868 Onal et al., 2012
tail stripe	SMED30001977	SMESG000035646.1	isotig23175	be_Smed_v2	PMID:22543868 Onal et al., 2012
neoblast	SMED30001977	SMESG000035646.1	SMED_28607_V2	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001977	SMESG000035646.1	SMED_28607_V2	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of SZ12-1 vs. Ensembl Human
Match: SUZ12 (SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101])

HSP 1 Score: 118.242 bits (295), Expect = 9.751e-27
Identity = 108/353 (30.59%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  PI K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  364 ETNDKSTAPIAK--PLATRNSESL--HQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 688

[Close]

BLAST of SZ12-1 vs. Ensembl Human
Match: SUZ12 (SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101])

HSP 1 Score: 117.857 bits (294), Expect = 1.019e-26
Identity = 108/353 (30.59%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  PI K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  341 ETNDKSTAPIAK--PLATRNSESL--HQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 665

[Close]

BLAST of SZ12-1 vs. Ensembl Fly
Match: Su(z)12 (gene:FBgn0020887 transcript:FBtr0074916)

HSP 1 Score: 89.7373 bits (221), Expect = 4.097e-18
Identity = 81/280 (28.93%), Postives = 134/280 (47.86%), Query Frame = 2

Query: 1337 VNIAYKFVVNEKIVQWTQ-TKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNL-----NQVNPNDFDFGYVLSENYPVRRMPLTELIY--YRYQKSAVKTF-----------RKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEV--KSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDK 2104
            + I Y F+ +    Q T+ T+ L CPWC      G D    +  LL HL   H+R  FT +   +   ++ T     D +      +   P+   F        PVRR  +T L+    R QK+ +  F           R Y   HNRLY HT + + +   E DIDSE E +  WL  +  + ++EFSD+N  EK+++++WN  ++ +G +V D QL    + F+      D +  E+  K++   F+LH+ +L D+G+++A  + + ++ L   L K
Sbjct:  389 IQIVYNFMYSNNTRQQTEYTQELNCPWC------GLDCLRLYA-LLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCG---PVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHG-FVGDCQLPIACEMFL------DAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSK 651

[Close]

BLAST of SZ12-1 vs. Ensembl Fly
Match: Su(z)12 (gene:FBgn0020887 transcript:FBtr0074917)

HSP 1 Score: 88.9669 bits (219), Expect = 7.067e-18
Identity = 81/280 (28.93%), Postives = 134/280 (47.86%), Query Frame = 2

Query: 1337 VNIAYKFVVNEKIVQWTQ-TKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNL-----NQVNPNDFDFGYVLSENYPVRRMPLTELIY--YRYQKSAVKTF-----------RKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEV--KSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDK 2104
            + I Y F+ +    Q T+ T+ L CPWC      G D    +  LL HL   H+R  FT +   +   ++ T     D +      +   P+   F        PVRR  +T L+    R QK+ +  F           R Y   HNRLY HT + + +   E DIDSE E +  WL  +  + ++EFSD+N  EK+++++WN  ++ +G +V D QL    + F+      D +  E+  K++   F+LH+ +L D+G+++A  + + ++ L   L K
Sbjct:  389 IQIVYNFMYSNNTRQQTEYTQELNCPWC------GLDCLRLYA-LLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCG---PVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHG-FVGDCQLPIACEMFL------DAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSK 651

[Close]

BLAST of SZ12-1 vs. Ensembl Zebrafish
Match: suz12a (SUZ12 polycomb repressive complex 2 subunit a [Source:NCBI gene;Acc:794171])

HSP 1 Score: 110.923 bits (276), Expect = 9.526e-25
Identity = 96/334 (28.74%), Postives = 164/334 (49.10%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYGEND-FTQDLRLSSIRLKEKEKIE----VNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWL 2086
            KP+ TRN        +  +KT +         ND    DL +     +E+  IE    +++ Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T+++  R ++S                  +T+   HNRLY H+ S   L+  E ++DSE E +  WL ++   ++EEF+D+N  EK+++++WN  ++ +G +++D+Q+     +F    +E    +   K++    +LHL+N+ DFG+++ A + + M  L
Sbjct:  340 KPLATRNSE---SSTVDSSKTSNVKPPQAVAVNDSLGTDLPVR----REQTHIEPCQKLHVYYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDILCQPGFAFSRNGPVKRTPVTQILVCRPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEMEVDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHG-FIADNQMNQACMSF----VEQHGTIMVEKNLCRNALLHLINMHDFGLITTATIDKAMTHL 646

[Close]

BLAST of SZ12-1 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 106.301 bits (264), Expect = 2.851e-23
Identity = 85/279 (30.47%), Postives = 145/279 (51.97%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN  ++  G +++D+Q+      F++  I   + ++  +++   F+LHLVNL DF +++ A + + M  L E
Sbjct:  385 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNG-FIADNQMSQASMLFVE--ICGPHIIR--RNLCRNFLLHLVNLHDFNLVTIATIDQAMARLKE 643

[Close]

BLAST of SZ12-1 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 99.3673 bits (246), Expect = 4.858e-21
Identity = 85/279 (30.47%), Postives = 135/279 (48.39%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN    S  +         FV+     II         +++   F+LHLVNL DF +++ A + + M  L E
Sbjct:  385 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHNFSILVITMIQASMLFVEICGPHIIR--------RNLCRNFLLHLVNLHDFNLVTIATIDQAMARLKE 640

[Close]

BLAST of SZ12-1 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 98.9821 bits (245), Expect = 6.548e-21
Identity = 89/283 (31.45%), Postives = 140/283 (49.47%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYV----SDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN  L ++ I V      S L  FV+     II         +++   F+LHLVNL DF +++ A + + M  L E
Sbjct:  386 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWN--LHNFSILVITIIQASML--FVEICGPHIIR--------RNLCRNFLLHLVNLHDFNLVTIATIDQAMARLKE 641

[Close]

BLAST of SZ12-1 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 121.324 bits (303), Expect = 7.398e-28
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  329 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 642

[Close]

BLAST of SZ12-1 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 120.939 bits (302), Expect = 7.551e-28
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  290 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 603

[Close]

BLAST of SZ12-1 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 121.324 bits (303), Expect = 8.367e-28
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  373 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 686

[Close]

BLAST of SZ12-1 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 120.553 bits (301), Expect = 1.016e-27
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  295 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 608

[Close]

BLAST of SZ12-1 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 120.553 bits (301), Expect = 1.326e-27
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  300 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 613

[Close]

BLAST of SZ12-1 vs. Ensembl Mouse
Match: Suz12 (SUZ12 polycomb repressive complex 2 subunit [Source:MGI Symbol;Acc:MGI:1261758])

HSP 1 Score: 117.472 bits (293), Expect = 1.018e-26
Identity = 107/353 (30.31%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  P+ K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  343 ETNDKSTAPVAK--PLATRNSESL--HQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 667

[Close]

BLAST of SZ12-1 vs. Ensembl Mouse
Match: Suz12 (SUZ12 polycomb repressive complex 2 subunit [Source:MGI Symbol;Acc:MGI:1261758])

HSP 1 Score: 117.472 bits (293), Expect = 1.109e-26
Identity = 107/353 (30.31%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  P+ K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  366 ETNDKSTAPVAK--PLATRNSESL--HQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 690

[Close]

BLAST of SZ12-1 vs. UniProt/SwissProt
Match: sp|Q0VA03|SUZ12_XENTR (Polycomb protein suz12 OS=Xenopus tropicalis OX=8364 GN=suz12 PE=2 SV=1)

HSP 1 Score: 120.939 bits (302), Expect = 5.158e-27
Identity = 104/342 (30.41%), Postives = 174/342 (50.88%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +   + DL+    R +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E D+DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV N+  +II+        K++   FMLHLV++ DF ++S   + + +  L E   K+
Sbjct:  332 KPLATRNSESLPQEHKPSSVKPAQTVAV----KESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMLFVDNYGPQIIQ--------KNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKV 645

[Close]

BLAST of SZ12-1 vs. UniProt/SwissProt
Match: sp|Q15022|SUZ12_HUMAN (Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3)

HSP 1 Score: 118.242 bits (295), Expect = 4.683e-26
Identity = 108/353 (30.59%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  PI K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  364 ETNDKSTAPIAK--PLATRNSESL--HQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 688

[Close]

BLAST of SZ12-1 vs. UniProt/SwissProt
Match: sp|Q80U70|SUZ12_MOUSE (Polycomb protein Suz12 OS=Mus musculus OX=10090 GN=Suz12 PE=1 SV=2)

HSP 1 Score: 117.472 bits (293), Expect = 7.759e-26
Identity = 107/353 (30.31%), Postives = 177/353 (50.14%), Query Frame = 2

Query: 1187 QTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKE---------KEKIEVN-------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            +T +KS  P+ K  P  TR+  S   + EN         +I +KE         KEK   N       I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V+++WN  ++ +G +++D+Q+ +    FV+N+ Q+II+        K++   FMLHLV++ DF ++S  ++ + +  L E   K+
Sbjct:  366 ETNDKSTAPVAK--PLATRNSESL--HQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHG-FIADNQMNHACMLFVENYGQKIIK--------KNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKL 690

[Close]

BLAST of SZ12-1 vs. UniProt/SwissProt
Match: sp|Q6DC03|SZ12A_DANRE (Polycomb protein suz12-A OS=Danio rerio OX=7955 GN=suz12a PE=2 SV=1)

HSP 1 Score: 110.538 bits (275), Expect = 8.961e-24
Identity = 96/334 (28.74%), Postives = 164/334 (49.10%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYGEND-FTQDLRLSSIRLKEKEKIE----VNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWL 2086
            KP+ TRN        +  +KT +         ND    DL +     +E+  IE    +++ Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T+++  R ++S                  +T+   HNRLY H+ S   L+  E ++DSE E +  WL ++   ++EEF+D+N  EK+++++WN  ++ +G +++D+Q+     +F    +E    +   K++    +LHL+N+ DFG+++ A + + M  L
Sbjct:  340 KPLATRNSE---SSTVDSSKTSNIKPPQAVAVNDSLGTDLPVR----REQTHIEPCQKLHVYYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDILCQPGFAFSRNGPVKRTPVTQILVCRPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEMEVDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHG-FIADNQMNQACMSF----VEQHGTIMVEKNLCRNALLHLINMHDFGLITTATIDKAMTHL 646

[Close]

BLAST of SZ12-1 vs. UniProt/SwissProt
Match: sp|B0R1D5|SZ12B_DANRE (Polycomb protein suz12-B OS=Danio rerio OX=7955 GN=suz12b PE=2 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 2.153e-22
Identity = 85/279 (30.47%), Postives = 145/279 (51.97%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN  ++  G +++D+Q+      F++  I   + ++  +++   F+LHLVNL DF +++ A + + M  L E
Sbjct:  385 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNG-FIADNQMSQASMLFVE--ICGPHIIR--RNLCRNFLLHLVNLHDFNLVTIATIDQAMARLKE 643

[Close]

BLAST of SZ12-1 vs. TrEMBL
Match: H9CXT5 (SZ12-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1285.01 bits (3324), Expect = 0.000e+0
Identity = 672/673 (99.85%), Postives = 672/673 (99.85%), Query Frame = 2

Query:   89 MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPXXXXXXXXXXXADNDSETQSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIXXXXXXXXXXVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNKADCQWCRIDDPQHXXXXXXXXXXXFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPIKKIRKIKKNKADNDSETQSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIKPNYPNYPNKVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNK DCQWCRIDDPQHKIINKNKAKIIFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI
Sbjct:    1 MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPIKKIRKIKKNKADNDSETQSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIKPNYPNYPNKVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNKXDCQWCRIDDPQHKIINKNKAKIIFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 673

[Close]

BLAST of SZ12-1 vs. TrEMBL
Match: A0A481NVF5 (Polycomb protein SUZ12-1 OS=Dugesia japonica OX=6161 GN=suz12-1 PE=2 SV=1)

HSP 1 Score: 936.021 bits (2418), Expect = 0.000e+0
Identity = 510/686 (74.34%), Postives = 589/686 (85.86%), Query Frame = 2

Query:   89 MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPXXXXXXXXXXXADNDSETQSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIXXXXXXXXXXVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKE--DKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLES-----ESSNKADCQWCRIDDPQHXXXXXXXXXXXFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGY--SAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKT---NKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFR-KYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            ML KNS   +KT+KYVKRRYSQALE DN+NEP +KIR+IKKNK DND ET S +E+V  SHS EFQDFLK+FMIPSN+YK LALRHKTNPIILKRNL+YL  +K+D QKSNLRTIADHLSTVRFHDENLALMKGKLP KP +PNYPNKV+FKFDQFVDSK+EKDWKTIE I+Y+DI+HFYRDNRKNK+SF V RVIS QKIKC+ED K++ K H I+IA +M+SA+ YRVYKSVFHFK+LAKEKKL+ KE  DK  DIYPVTYEAMMPLF+NTC+RNLRS N+FVQSGKYQIYMDVT+MEKCD+S +NGTT+IVYNNN +  S     +S+N+ DCQW RIDDPQHKI+NKNK KI+FEI N E  K KNKPMQTRNKSLPPIIK+SP K   G+  S+    +ND  +DLRLSSI+LKEKEKI+VNIAYKFVV EKIVQWTQTKHL CPWC LNF+   DL++TFQ+LLSHLNNWHS+L+FTCKKLK+R + N+    N IT+DV LN+V+PND DFG++LS ++P+RRMPLTELI+ +YQK  VK  + K HNR YSHTWSA++LK  EFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWN ELLSYG+YVSD Q+E+ VKNFI+RIIE +NQLKEVKSMRNTFMLHL+NL+DFGVLS+A ML+CMK LDEA DKI
Sbjct:    1 MLNKNSNYNNKTDKYVKRRYSQALENDNLNEPTRKIRRIKKNKLDNDLETLSFTEEV-NSHSAEFQDFLKYFMIPSNMYKTLALRHKTNPIILKRNLTYLAKNKSDNQKSNLRTIADHLSTVRFHDENLALMKGKLPFKPTFPNYPNKVVFKFDQFVDSKSEKDWKTIEAIIYLDIIHFYRDNRKNKDSFIVNRVISNQKIKCSEDNKADHKFHIIDIASVMQSASCYRVYKSVFHFKILAKEKKLSCKEKDDKRSDIYPVTYEAMMPLFNNTCNRNLRSLNFFVQSGKYQIYMDVTNMEKCDDSFFNGTTKIVYNNNNNNNSNENGLDSNNQLDCQWYRIDDPQHKIVNKNKVKILFEIDNEETLKAKNKPMQTRNKSLPPIIKMSPYKIGGGWNMSSSDVVDNDCVKDLRLSSIKLKEKEKIDVNIAYKFVVKEKIVQWTQTKHLTCPWCQLNFHLFTDLFDTFQKLLSHLNNWHSKLIFTCKKLKSRASFNQALEGNFITIDVKLNEVSPNDLDFGHMLSNDFPIRRMPLTELIFSKYQKPVVKKIQHKNHNRKYSHTWSAINLKPVEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNKELLSYGVYVSDIQIEHLVKNFIERIIEKENQLKEVKSMRNTFMLHLMNLIDFGVLSSATMLQCMKRLDEAFDKI 685

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BLAST of SZ12-1 vs. TrEMBL
Match: A0A4V3SF31 (VEFS-Box domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_005151 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 7.957e-27
Identity = 114/394 (28.93%), Postives = 171/394 (43.40%), Query Frame = 2

Query: 1157 EVEKVKNK-------PMQTRNKS---LPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNR------MTLNKTNKITVDVNLNQ--------------VNPNDFDFG------------------------YVLSENYPVRRMPLTELIYYRYQKS----------AVKTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYG---IYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI*CCCSNFDIQ 2137
            +V K  NK       P++ R++S   LPP +  SP +TR   S   +     T  LR               + Y+F+   ++ QW++ K L+CPWC L+     +     + LL HL   H R  F      +R      ++LN+    + D  L +              V P     G                        Y    + PVRR+  T LI++R  +           +V+     HNR+Y HT S   L+  EFD DSE+E+  +WL   Y RKVEEF+D+N  EK+++Q+WN  LLS G   + V DSQL N    F+QR     ++    + +RN  +LH  NLVD+G+LS       ++ L    DK+ C  +   +Q
Sbjct:  711 QVPKFSNKTPVTQEAPVEQRSQSRLLLPPPLSQSPARTRRLASTRPHLPTPATLPLR--------------PVTYRFLYMNRLQQWSEAKDLVCPWCRLDCWRARE--RGPEALLVHLRTCHPRFRFKASWSPSRAHLSLEVSLNEAYDGSNDCGLRRWGFPSSDGAASRRLVAPGQLIGGWTGLGSLPAQLEQQQPTASLSLSTYASRVSRPVRRLSYTHLIFWRGAERVTDQPLDPTLSVRPVALGHNRVYYHTRSVQPLRACEFDHDSEAEDAPEWLRQHYQRKVEEFTDVNQGEKQLMQLWNALLLSIGPSELVVCDSQLANLAACFVQRYASAIHR----RHLRNNLILHFANLVDYGLLSPGQ----LRQLVTMYDKLVCSSTPGRVQ 1080

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BLAST of SZ12-1 vs. TrEMBL
Match: A0A481NWA7 (Polycomb protein SUZ12-2 OS=Dugesia japonica OX=6161 GN=suz12-2 PE=2 SV=1)

HSP 1 Score: 124.79 bits (312), Expect = 5.561e-26
Identity = 155/643 (24.11%), Postives = 282/643 (43.86%), Query Frame = 2

Query:  278 EFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKS--NLRTIADHLSTVRFHDENLALMKGKLPIXXXXXXXXXXVIFK-------FDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCN----EDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKL--------NGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNKADCQWCRIDDPQHXXXXXXXXXXXFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTN--KITVDVNLNQVNPNDFDFGY-----VLSENYPVRRMPLTELIYYRYQKSA----------VKTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            E+++ +K     +++Y  L +  K +  +L RNLSY+   +  +++   NL  I + L  VR            +P   +  +     + K       F  F DS  E  W+TI     + ++H ++++RK +      + +S   I CN    ED K  QK H  + + +    +  R+  S   FK+   E++         N + ++   +Y V YE   P +    + N     +++  G+Y++ ++V+ +++   S+ +      + NN+ +    S+  +  W R   P   +                 E  K   +  R +S   + K+  N          Y  N     +     +   K K+EVNI YKF  N  ++QW++++ + CPWC       N    +F  L+ HL  +H+R  F          +++TN   + ++V LN+      + G        S   P R++P T ++Y                 ++     HNR Y ++ + +     + D+DSE+E+N  WL   Y++++EEF+D+N  EK+++Q+WN  LL +  Y  D  +    K+F   II+   ++KE     N  +LHLVNLV+FGVLS   ++E +  LD+
Sbjct:   20 EYEEIIKRLGYITSLYGYLKINFKRSHFLLFRNLSYIQGDRNSVKRKFKNLDKICERLIKVR------------IPRVRSLCDSSQFSVLKEVNWNLIFVGFFDSSHESQWETIHAYADIYVIHHWKNSRKFQSGKKTTKFLSNLLINCNGRPLEDGKF-QKIHEFSQSQLFHDTSHLRIVYSYLLFKLRVLERRTVDYSKIESNLQINQNNGLYAVHYELKFPFYKFRSNDN--DLKFYLLPGEYEMRLEVS-LDQPTESLAD------FTNNEMVIENFSDSPERIWVREVSPSSSVAK---------------EYDKWPRILFRLESSNSLTKLDTNSV----DIKPYISNGVIDKVS----KKARKAKLEVNIVYKFYHNNHMLQWSRSQSVKCPWCNFICEKSNAKL-SFSCLVKHLQTFHARFTF------KHWVISETNISSMIIEVRLNECYDGSIEIGLRSSMESRSLEKPERKLPFTHIVYCSQMCKINPMVNNPSIDLRPLVWGHNRKYFYSTTGIVKCIGDLDVDSEAEDNLDWLQQMYFKRIEEFTDVNPGEKRIMQLWNSHLLDHK-YNGDFMVPILTKSF---IIQKGAEIKEHNLRNNL-LLHLVNLVEFGVLSQKQLIEVIGILDQ 605

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BLAST of SZ12-1 vs. TrEMBL
Match: C6GGW6 (Suppressor of zeste 12 OS=Xenopus laevis OX=8355 GN=suz12 PE=2 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 2.258e-25
Identity = 103/342 (30.12%), Postives = 177/342 (51.75%), Query Frame = 2

Query: 1178 KPMQTRN-KSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR-LKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN +SLP   K S  K     +     +  F+ DL+    R +  +++ ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    L+ HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R P+T ++  R +++                  +T+   HNRLY H+ + + L+  E ++DSE E++ +WL ++   ++EEFSD+N  EK+V++MWN  ++ +G +++D+Q+ +    FV+N+   I++        K++   FMLHLV++ DF ++S A + + +  L E   K+
Sbjct:  332 KPLATRNSESLPQEHKPSSVKPAQTIAV----KESFSSDLQARKERDVSTEQRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LIKHLKLCHSRFIF------NYVYHPKGARI--DVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHG-FIADNQMNHGCMQFVENYGPEIVQ--------KNLCRNFMLHLVSMHDFNLISIATIDKAVTRLREIQQKL 645

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BLAST of SZ12-1 vs. Ensembl Cavefish
Match: suz12a (polycomb protein suz12-A-like [Source:NCBI gene;Acc:103046942])

HSP 1 Score: 110.538 bits (275), Expect = 1.176e-24
Identity = 96/334 (28.74%), Postives = 160/334 (47.90%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVN-----LNQVNPNDF--DFGYVLSENYPVRRMPLTELIYYR--YQKSAVKTF-----------RKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQR----IIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEA 2095
            +P+ TRN          P+  +   +            +R   + ++ ++K+ V   Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I V VN         NP D     G+  S N PV+R  ++ ++  R  + K ++  F           R Y   HNRLY H+ S M L+  E ++DSE E +  WL ++   ++EEF+D+N  EK+V++MWN  ++ +G +++D+Q+      F+++    IIE        K++   F+LHLV++ DFG++S   + + M  L + 
Sbjct:  336 RPLATRNSDTSGGDSHRPSAPKPPQAVAVKDPVSADMPVRREQVHIEPRQKLRV--YYQFLYNNNTRQQTEARDDLHCPWCTLNCRR---LYS----LLKHLKLSHSRFIF------NYVPHPKGARIDVSVNDCYDGSYVGNPQDIHCQPGFAFSRNGPVKRTSVSHVLVCRPKHPKPSLSEFLESEEGQLEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPDWLREKTTMQIEEFTDVNEGEKEVMKMWNLHVMKHG-FIADNQMNQACMLFVEKCGSTIIE--------KNLCRNFLLHLVSMHDFGLVSTMTIDKAMALLRQG 645

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BLAST of SZ12-1 vs. Ensembl Cavefish
Match: suz12a (polycomb protein suz12-A-like [Source:NCBI gene;Acc:103046942])

HSP 1 Score: 110.153 bits (274), Expect = 1.403e-24
Identity = 96/323 (29.72%), Postives = 156/323 (48.30%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVN-----LNQVNPNDF--DFGYVLSENYPVRRMPLTELIYYR--YQKSAVKTF-----------RKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQR----IIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAA 2062
            +P+ TRN          P+  +   +            +R   + ++ ++K+ V   Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I V VN         NP D     G+  S N PV+R  ++ ++  R  + K ++  F           R Y   HNRLY H+ S M L+  E ++DSE E +  WL ++   ++EEF+D+N  EK+V++MWN  ++ +G +++D+Q+      F+++    IIE        K++   F+LHLV++ DFG+ S AA
Sbjct:  336 RPLATRNSDTSGGDSHRPSAPKPPQAVAVKDPVSADMPVRREQVHIEPRQKLRV--YYQFLYNNNTRQQTEARDDLHCPWCTLNCRR---LYS----LLKHLKLSHSRFIF------NYVPHPKGARIDVSVNDCYDGSYVGNPQDIHCQPGFAFSRNGPVKRTSVSHVLVCRPKHPKPSLSEFLESEEGQLEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPDWLREKTTMQIEEFTDVNEGEKEVMKMWNLHVMKHG-FIADNQMNQACMLFVEKCGSTIIE--------KNLCRNFLLHLVSMHDFGLASRAA 634

[Close]

BLAST of SZ12-1 vs. Ensembl Cavefish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:103037652])

HSP 1 Score: 105.531 bits (262), Expect = 4.578e-23
Identity = 84/279 (30.11%), Postives = 141/279 (50.54%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN  ++  G +++D+Q+   +  F++        +      RN F+LHLV++ DF +++ A +   M  L E
Sbjct:  405 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEMDSEDERDPEWLREKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNG-FIADNQMNQAIMLFVENC---GPHIARRNLCRN-FLLHLVSMHDFNLVTTATIDRAMTRLRE 663

[Close]

BLAST of SZ12-1 vs. Ensembl Cavefish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:103037652])

HSP 1 Score: 104.76 bits (260), Expect = 7.311e-23
Identity = 83/279 (29.75%), Postives = 142/279 (50.90%), Query Frame = 2

Query: 1334 EVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++ I Y+F+ N    Q T+ +  L CPWC LN      LY+    LL HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   ++EEF+D+N  EK+V+++WN  ++  G +++D+Q+   +  F    +E+       +++   F+LHLV++ DF +++ A +   M  L E
Sbjct:  378 KLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEMDSEDERDPEWLREKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNG-FIADNQMNQAIMLF----VENCGPHIARRNLCRNFLLHLVSMHDFNLVTTATIDRAMTRLRE 636

[Close]

BLAST of SZ12-1 vs. Ensembl Sea Lamprey
Match: suz12a (SUZ12 polycomb repressive complex 2 subunit a [Source:NCBI gene;Acc:794171])

HSP 1 Score: 98.5969 bits (244), Expect = 1.157e-21
Identity = 94/340 (27.65%), Postives = 158/340 (46.47%), Query Frame = 2

Query: 1175 NKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFT-----QDLRLSSIRLK-EKEKIE----VNIAYKFVVNEKIVQWTQTKHLI-CPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLN-----QVNPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKS-------------AVKTFRKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENF-----VKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECM 2077
            +K      K L P   + P+ + DG +A        T     +D   SS+++K E  ++E    + I Y+F+ N  + Q T+ +  + CPWC LN      LY+    LL HL   H R +F      N + L K  +I V VN         NP D     G+  S N PV+R P+T ++  R ++               V+  R Y   H+RLY H  + + L+  E D DSE E + +WL ++   +++EF D+N  EK++++MWN  ++ +G+ +      +F     V+ +  R++E          +    +LHL++L DF ++  A++   M
Sbjct:  293 DKAFTPSAKPLTPRNIVDPSASADGRNAATQKPAAPTGTSGVKDQLSSSVQVKKEPGQMEPQKKLRIYYQFLYNNNLRQQTEARDDVHCPWCTLNCGK---LYS----LLKHLKLCHGRFIF------NYVPLTKGARIDVSVNECYDGSYAGNPQDIHSQPGFAFSRNGPVKRTPVTYILVCRPKRPKPSLSEFLESDELEVEQQRPYVSGHDRLYFHKDTCLPLRPQEMDEDSEDENDPEWLREKTVLQIDEFMDVNEGEKELMKMWNLHVMKHGVTMLAKGEGHFCYFINVEQWGPRLLE--------MGLFQNLLLHLISLHDFNLIGQASVQAAM 611

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BLAST of SZ12-1 vs. Ensembl Nematostella
Match: EDO42650 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0W2])

HSP 1 Score: 94.3597 bits (233), Expect = 4.482e-20
Identity = 83/282 (29.43%), Postives = 135/282 (47.87%), Query Frame = 2

Query: 1316 KEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQ--KSAVKTF---------RKYHN---RLYSH--TWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKS--MRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDK 2104
            KEK      + Y+F+ N    Q T+ +H   CPWC +N +    LYN    LL HL   HSR  FT         ++       D  +  VN      GY  S   P RR+P   ++ +R Q  K ++  F         R YH+   R Y H  T   +S  +     DSE EEN  W+  +  + +++F+D+N  EK+++++WN  L+  G YV+D+Q+ +    FI      D   K++ S  ++  F++HLV+L DF +L+   + + M+ L +  ++
Sbjct:  347 KEKTNKAQILYYQFIYNSHTRQQTEARHDFCCPWCHVNCSK---LYN----LLKHLKLCHSRFTFTYAPHSKGARIDVCVNEHYDGKMEGVNDA---LGYAFSREGPCRRVPFNHVLAWRPQRRKESLSEFLEPDDADENRPYHSGYTRTYFHSSTCVPISQSELGSLSDSEGEENPLWMRMRTIQMIDDFTDVNDGEKELMKLWNLHLMEKG-YVADAQVYSACLTFI------DVNAKKIMSQNLKRNFLIHLVSLHDFNLLNGGQIFQLMQKLKDVANE 611

[Close]

BLAST of SZ12-1 vs. Ensembl Medaka
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:101158330])

HSP 1 Score: 114.005 bits (284), Expect = 1.035e-25
Identity = 95/342 (27.78%), Postives = 169/342 (49.42%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYG--ENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN         SP +TR  +        +   + D+++    +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN +    LY+    L+ HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++   +++EF+D+N  EK+V+++WN  ++ +G +++D+Q+      FV+N    II         +++   F+LHLV++ DF ++S A +   M  L +  D++
Sbjct:  341 KPLATRNSG-----STSPMETRTSHHRAALMALKESVSADIQMKKELVPCEPRQKIRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCSK---LYS----LIKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVSRPKRTKPSLSEFLESEDGELEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLREKTSMQLDEFTDVNEGEKEVMKLWNLHVMKHG-FIADNQMNQAIMLFVENRGAHIIR--------RNLCRNFLLHLVSMHDFNLVSTATIDRAMARLQQIQDEL 653

[Close]

BLAST of SZ12-1 vs. Ensembl Medaka
Match: suz12a (polycomb protein suz12-A [Source:NCBI gene;Acc:101158611])

HSP 1 Score: 103.605 bits (257), Expect = 2.135e-22
Identity = 100/354 (28.25%), Postives = 163/354 (46.05%), Query Frame = 2

Query: 1196 NKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIR------LKEKEKIEVN---------------IAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLN-----QVNPNDF--DFGYVLSENYPVRRMPLTELIYYRYQ--KSAVKTF------------RKY---HNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
             +S  P+ K  P  TR+         +D  QD R S++R      +KE    +V+               I Y+F  N    Q T+ +  L CPWC LN      LY+    LL HL   HSR VF      N +   K  K+ V +N         NP D     G+  S N PV+R P+T ++  R +  K ++  F            R Y   HNRLY H+ S + L+  E D DSE E +  WL ++  +++EEF+D+N  EK+++++WN  ++ +G +++D+Q+      F +     ++E        + +   F+LHL+++ DF ++  A        +D+A+ K+
Sbjct:  334 GRSTAPVAK--PLATRN---------SDTNQDSRPSTLRAAHAPAVKESPSADVHAKREQVSAEPRQKLRIFYQFQYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFVF------NYVPHPKGAKVEVSINECYDGSYAGNPQDVHNQPGFAFSRNGPVKRTPVTHVLVCRPKRVKPSLSEFLESEDGDREQHQRTYISGHNRLYFHSDSCVPLRPQEMDEDSEDERDPDWLKEKTMKQIEEFTDVNEGEKEIMKLWNLHVMKHG-FIADNQMNKACLLFAEQHAALVVE--------RGLGRNFLLHLISMHDFNLIGTAT-------IDQAVAKL 647

[Close]

BLAST of SZ12-1 vs. Ensembl Medaka
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:101158330])

HSP 1 Score: 92.8189 bits (229), Expect = 3.746e-19
Identity = 91/343 (26.53%), Postives = 157/343 (45.77%), Query Frame = 2

Query: 1178 KPMQTRNKSLPPIIKISPNKTRDGYSAGGYG--ENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQV-------NPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYR-KVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            KP+ TRN         SP +TR  +        +   + D+++    +  + + ++ I Y+F+ N    Q T+ +  L CPWC LN +    LY+    L+ HL   HSR +F      N +   K  +I  DV++N+        NP D     G+  S N PV+R  +T ++  R +++                  +T+   HNRLY H+ S M L+  E ++DSE E + +WL ++    +  E  D  +  KK+    N   +   I+++D+Q+      FV+N    II         +++   F+LHLV++ DF ++S A +   M  L +  D++
Sbjct:  334 KPLATRNSG-----STSPMETRTSHHRAALMALKESVSADIQMKKELVPCEPRQKIRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCS---KLYS----LIKHLKLSHSRFIF------NYVPHPKGARI--DVSINECYDGSYVGNPQDIHSQPGFAFSRNGPVKRTAVTHILVSRPKRTKPSLSEFLESEDGELEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLREKTSMVRTGEICDSGNWRKKIWGFLNEHTVKKNIFIADNQMNQAIMLFVENRGAHIIR--------RNLCRNFLLHLVSMHDFNLVSTATIDRAMARLQQIQDEL 648

[Close]

BLAST of SZ12-1 vs. Ensembl Medaka
Match: suz12a (polycomb protein suz12-A [Source:NCBI gene;Acc:101158611])

HSP 1 Score: 67.3958 bits (163), Expect = 4.126e-11
Identity = 88/342 (25.73%), Postives = 142/342 (41.52%), Query Frame = 2

Query: 1196 NKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSS-----IRLKEKEKIE----VNIAYKFVVNEKIVQWTQTKH-LICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLN-----QVNPNDF--DFGYVLSENYPVRRMPLTELIYYRYQKSAV-----------------KTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLEN----FVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
             +S  P+ K  P  TR+         +D  QD R S+       L+E+   E    + I Y+F  N    Q T+ +  L CPWC LN      LY+    LL HL   HSR VF      N +   K  K+ V +N         NP D     G+  S N PV+R P+T ++  R ++                    +T+   HNRLY H+ S + L+  E D DSE E +  WL                 ++K +++     L+   +++D+Q+      F +     ++E        + +   F+LHL+++ DF ++  A        +D+A+ K+
Sbjct:  314 GRSTAPVAK--PLATRN---------SDTNQDSRPSTSCPKKTVLREQVSAEPRQKLRIFYQFQYNNNTRQQTEARDDLHCPWCTLNCRK---LYS----LLKHLKLSHSRFVF------NYVPHPKGAKVEVSINECYDGSYAGNPQDVHNQPGFAFSRNGPVKRTPVTHVLVCRPKRVKPSLSEFLESEDGDREQHQRTYISGHNRLYFHSDSCVPLRPQEMDEDSEDERDPDWL-----------------KEKTMKVRGG--LAGRGFIADNQMNKACLLFAEQHAALVVE--------RGLGRNFLLHLISMHDFNLIGTAT-------IDQAVAKL 597

[Close]

BLAST of SZ12-1 vs. Planmine SMEST
Match: SMESG000035646.1 (SMESG000035646.1)

HSP 1 Score: 1281.93 bits (3316), Expect = 0.000e+0
Identity = 670/673 (99.55%), Postives = 671/673 (99.70%), Query Frame = 2

Query:   89 MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPXXXXXXXXXXXADNDSETQSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIXXXXXXXXXXVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNKADCQWCRIDDPQHXXXXXXXXXXXFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 2107
            MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPIKKIRKIKKNKADNDSETQS SEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIKPNYPNYPNKVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNK+DCQWCRIDDPQHKIINKNKAKIIFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVV EKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI
Sbjct:    1 MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPIKKIRKIKKNKADNDSETQSFSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIKPNYPNYPNKVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQDLESESSNKSDCQWCRIDDPQHKIINKNKAKIIFEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQDLRLSSIRLKEKEKIEVNIAYKFVVKEKIVQWTQTKHLICPWCLLNFNSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWSAMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDEALDKI 673

[Close]

BLAST of SZ12-1 vs. Planmine SMEST
Match: SMESG000054377.1 (SMESG000054377.1)

HSP 1 Score: 94.7449 bits (234), Expect = 5.843e-20
Identity = 88/271 (32.47%), Postives = 145/271 (53.51%), Query Frame = 2

Query: 1331 IEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNF-NSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLS-ENY----PVRRMPLTELIYYRYQKSAVKTFRK-----------YHNRLYSHTWSAMSLKXXXXXXXXXXXXNKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVDFGVLSAAAMLECMKWLDE 2092
            ++VN+ YKF  N  ++QWT+++ + CPWC  NF    N    +F  L+ HL  +H+R  F   K     ++N  + I ++V LN+      + G   S EN     P R++P T +IY  +Q   +    K            HNR Y ++ + +     + D+DSE+E+N  WL   Y++++EEF+D+N  EK+++Q+WN  LL +  Y  D  +    K+F   I++   ++KE     N  +LHLVNLV+FG+LS   ++E +  LD+
Sbjct:  348 LDVNVVYKFFHNNHLLQWTRSQSVKCPWC--NFICEKNTTKLSFNCLMKHLQTFHARFTF---KYFGIPSVN-ISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYC-FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHK-YNGDFMVPILTKSF---ILQKGTEIKEHNLRNNL-LLHLVNLVEFGLLSQKQLIEVIGLLDQ 606

HSP 2 Score: 55.4546 bits (132), Expect = 1.123e-7
Identity = 62/286 (21.68%), Postives = 118/286 (41.26%), Query Frame = 2

Query:  278 EFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSK-----------------TDIQKSNLRTIAD--HLSTVRFHDENLALMKGKLPIXXXXXXXXXXVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNE----DMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKK--------LNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKCDNSVYNGTTRIVYNNNQD 1042
            E+++ +K     S++Y  L +  K +  +L RNLSY+  ++                   I+   +R+  D  H ST++  D N  L+                    F  F DS  E  W+TI     + ++H ++++RK +      + +S   IKCN     D +  QK H    + + +  N  RV  S   FK+   E++         N + +     Y V YE   P +    + N     +++  G+Y++ ++V+  +  ++   + T+  V++N  D
Sbjct:   20 EYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFKKKLKKIDKICERLVKIRIPRVRSSVDTNHFSTIK--DINWNLI--------------------FIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDN--DLKFYLLPGEYEMRLEVSLDQPTESLSGSTTSESVFDNVTD 281

The following BLAST results are available for this feature:

BLAST of SZ12-1 vs. Ensembl Human
BLAST of SZ12-1 vs. Ensembl Celegans
BLAST of SZ12-1 vs. Ensembl Fly
BLAST of SZ12-1 vs. Ensembl Zebrafish
BLAST of SZ12-1 vs. Ensembl Xenopus
BLAST of SZ12-1 vs. Ensembl Mouse
BLAST of SZ12-1 vs. UniProt/SwissProt
BLAST of SZ12-1 vs. TrEMBL
BLAST of SZ12-1 vs. Ensembl Cavefish
BLAST of SZ12-1 vs. Ensembl Sea Lamprey
BLAST of SZ12-1 vs. Ensembl Yeast
BLAST of SZ12-1 vs. Ensembl Nematostella
BLAST of SZ12-1 vs. Ensembl Medaka
BLAST of SZ12-1 vs. Planmine SMEST

BLAST of SZ12-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
SUZ12	9.751e-27	30.59	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]
SUZ12	1.019e-26	30.59	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]

BLAST of SZ12-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SZ12-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Su(z)12	4.097e-18	28.93	gene:FBgn0020887 transcript:FBtr0074916	[more]
Su(z)12	7.067e-18	28.93	gene:FBgn0020887 transcript:FBtr0074917	[more]

BLAST of SZ12-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
suz12a	9.526e-25	28.74	SUZ12 polycomb repressive complex 2 subunit a [Sou...	[more]
suz12b	2.851e-23	30.47	SUZ12 polycomb repressive complex 2 subunit b [Sou...	[more]
suz12b	4.858e-21	30.47	SUZ12 polycomb repressive complex 2 subunit b [Sou...	[more]
suz12b	6.548e-21	31.45	SUZ12 polycomb repressive complex 2 subunit b [Sou...	[more]

BLAST of SZ12-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
suz12	7.398e-28	30.41	SUZ12, polycomb repressive complex 2 subunit [Sour...	[more]
suz12	7.551e-28	30.41	SUZ12, polycomb repressive complex 2 subunit [Sour...	[more]
suz12	8.367e-28	30.41	SUZ12, polycomb repressive complex 2 subunit [Sour...	[more]
suz12	1.016e-27	30.41	SUZ12, polycomb repressive complex 2 subunit [Sour...	[more]
suz12	1.326e-27	30.41	SUZ12, polycomb repressive complex 2 subunit [Sour...	[more]

BLAST of SZ12-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Suz12	1.018e-26	30.31	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]
Suz12	1.109e-26	30.31	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]

BLAST of SZ12-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q0VA03\|SUZ12_XENTR	5.158e-27	30.41	Polycomb protein suz12 OS=Xenopus tropicalis OX=83...	[more]
sp\|Q15022\|SUZ12_HUMAN	4.683e-26	30.59	Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=...	[more]
sp\|Q80U70\|SUZ12_MOUSE	7.759e-26	30.31	Polycomb protein Suz12 OS=Mus musculus OX=10090 GN...	[more]
sp\|Q6DC03\|SZ12A_DANRE	8.961e-24	28.74	Polycomb protein suz12-A OS=Danio rerio OX=7955 GN...	[more]
sp\|B0R1D5\|SZ12B_DANRE	2.153e-22	30.47	Polycomb protein suz12-B OS=Danio rerio OX=7955 GN...	[more]

BLAST of SZ12-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
H9CXT5	0.000e+0	99.85	SZ12-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=...	[more]
A0A481NVF5	0.000e+0	74.34	Polycomb protein SUZ12-1 OS=Dugesia japonica OX=61...	[more]
A0A4V3SF31	7.957e-27	28.93	VEFS-Box domain-containing protein OS=Opisthorchis...	[more]
A0A481NWA7	5.561e-26	24.11	Polycomb protein SUZ12-2 OS=Dugesia japonica OX=61...	[more]
C6GGW6	2.258e-25	30.12	Suppressor of zeste 12 OS=Xenopus laevis OX=8355 G...	[more]

BLAST of SZ12-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
suz12a	1.176e-24	28.74	polycomb protein suz12-A-like [Source:NCBI gene;Ac...	[more]
suz12a	1.403e-24	29.72	polycomb protein suz12-A-like [Source:NCBI gene;Ac...	[more]
suz12b	4.578e-23	30.11	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]
suz12b	7.311e-23	29.75	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]

BLAST of SZ12-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
suz12a	1.157e-21	27.65	SUZ12 polycomb repressive complex 2 subunit a [Sou...	[more]

BLAST of SZ12-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of SZ12-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO42650	4.482e-20	29.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of SZ12-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
suz12b	1.035e-25	27.78	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]
suz12a	2.135e-22	28.25	polycomb protein suz12-A [Source:NCBI gene;Acc:101...	[more]
suz12b	3.746e-19	26.53	SUZ12 polycomb repressive complex 2 subunit [Sourc...	[more]
suz12a	4.126e-11	25.73	polycomb protein suz12-A [Source:NCBI gene;Acc:101...	[more]

BLAST of SZ12-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000035646.1	0.000e+0	99.55	SMESG000035646.1	[more]
SMESG000054377.1	5.843e-20	32.47	SMESG000054377.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30001977
GenBank	AFD29606.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30001977 ID=SMED30001977|Name=SZ12-1|organism=Schmidtea mediterranea sexual|type=transcript|length=2227bp
CATCTCACGGAAATTCTCGATTTTAATAGGTCATATTCTTTTTGAAATTC
ATTGTTATTTTAGTTCACTGTTTTATTGTTGAGATTTTATGTTGACTAAA
AATTCTTTGTGTTTTCATAAAACGGAAAAATATGTTAAAAGAAGATATTC
TCAAGCTTTAGAAATTGATAATGTAAATGAACCGATCAAGAAAATAAGAA
AAATAAAAAAAAATAAAGCTGATAATGATTCGGAGACGCAGTCTCTTTCT
GAAGACGTACTTAAGTCACATAGCGTAGAATTTCAAGATTTTCTTAAACA
TTTTATGATTCCATCAAATATATATAAGAATCTAGCTTTGCGGCACAAGA
CAAATCCTATTATTTTAAAACGAAATTTATCTTACCTTAATCACAGTAAA
ACAGATATCCAAAAATCTAATTTACGCACTATTGCCGATCATTTATCTAC
TGTAAGATTCCATGACGAGAATTTAGCACTTATGAAAGGTAAATTACCAA
TTAAACCCAATTACCCAAACTATCCGAATAAAGTAATATTTAAATTCGAC
CAATTTGTTGATAGTAAAACAGAAAAAGATTGGAAAACTATAGAAGGGAT
TGTTTACATGGATATAGTCCATTTTTATCGGGATAATCGCAAAAACAAAG
AATCCTTCACTGTAAAACGAGTGATATCCGGTCAGAAAATCAAATGCAAC
GAAGACATGAAATCAGAACAGAAATCTCACTCTATTAACATTGCCGACAT
AATGAAAAGCGCTAATTTTTATCGTGTCTACAAATCTGTCTTTCATTTTA
AAGTACTAGCCAAAGAGAAAAAGTTAAACGGAAAGGAAGACAAAACCGGT
GACATCTATCCAGTCACATATGAAGCTATGATGCCTCTGTTTAGTAACAC
TTGCAGTCGAAATTTACGATCATCGAATTACTTTGTGCAATCTGGTAAAT
ATCAAATCTACATGGACGTGACAGACATGGAAAAATGTGACAATTCCGTT
TATAATGGCACAACTCGGATCGTTTACAACAACAATCAGGATTTGGAATC
TGAATCCAGCAATAAAGCCGATTGCCAATGGTGTCGAATAGATGATCCTC
AACATAAAATCATCAACAAGAACAAAGCGAAAATCATTTTTGAAATTTGC
AATCATGAGGTGGAAAAAGTGAAAAACAAACCGATGCAAACCCGAAACAA
ATCGCTTCCACCGATAATCAAAATCTCTCCAAATAAAACCAGAGATGGAT
ACTCAGCCGGCGGTTACGGAGAGAACGATTTTACTCAAGATTTACGATTG
TCATCGATAAGATTAAAAGAGAAAGAGAAAATTGAAGTGAATATTGCATA
TAAATTCGTTGTAAATGAGAAAATCGTCCAGTGGACCCAAACGAAACATT
TGATTTGCCCATGGTGCCTACTAAATTTCAACTCAGGCAATGATCTCTAT
AATACTTTCCAACAGCTGTTATCGCATTTGAACAATTGGCATTCCAGATT
GGTTTTTACTTGTAAAAAATTGAAAAATCGCATGACTTTGAATAAGACAA
ATAAAATCACTGTCGATGTCAATCTTAATCAGGTAAATCCAAATGATTTT
GATTTTGGGTACGTTTTATCAGAAAACTATCCAGTGAGGCGCATGCCCTT
GACGGAACTGATTTATTACAGATATCAGAAATCAGCAGTGAAAACCTTTA
GGAAATACCATAATCGGTTGTACAGTCATACCTGGTCGGCCATGTCACTG
AAAGACGATGAATTTGACATTGATTCGGAATCAGAAGAAAACAAACAATG
GTTATTTGATCAATATTACCGGAAAGTTGAGGAGTTCAGCGATCTGAATC
ATATTGAAAAGAAAGTCATTCAAATGTGGAATCACGAGTTGCTGAGTTAT
GGGATTTACGTCAGCGATAGTCAATTGGAGAATTTCGTCAAAAATTTCAT
TCAGCGAATAATTGAAGATGACAACCAATTGAAAGAGGTGAAATCAATGC
GAAACACATTTATGTTACATTTAGTGAACTTGGTCGATTTCGGAGTTTTA
TCAGCAGCTGCAATGCTCGAATGCATGAAATGGCTCGATGAGGCCTTGGA
TAAAATTTAATGTTGTTGTTCAAATTTTGATATTCAATATTTTATGTGGA
TTTGTGTTTTGAATAATGATTAAATTTCTAATTAAGTGGTACTTTGAATC
TGTTTATGTGCATTTCTGTTGTTGTTG

protein sequence of SMED30001977-orf-1

>SMED30001977-orf-1 ID=SMED30001977-orf-1|Name=SMED30001977-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=674bp
MLTKNSLCFHKTEKYVKRRYSQALEIDNVNEPIKKIRKIKKNKADNDSET
QSLSEDVLKSHSVEFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYL
NHSKTDIQKSNLRTIADHLSTVRFHDENLALMKGKLPIKPNYPNYPNKVI
FKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQK
IKCNEDMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKKLNGKE
DKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVTDMEKC
DNSVYNGTTRIVYNNNQDLESESSNKADCQWCRIDDPQHKIINKNKAKII
FEICNHEVEKVKNKPMQTRNKSLPPIIKISPNKTRDGYSAGGYGENDFTQ
DLRLSSIRLKEKEKIEVNIAYKFVVNEKIVQWTQTKHLICPWCLLNFNSG
NDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVN
PNDFDFGYVLSENYPVRRMPLTELIYYRYQKSAVKTFRKYHNRLYSHTWS
AMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHE
LLSYGIYVSDSQLENFVKNFIQRIIEDDNQLKEVKSMRNTFMLHLVNLVD
FGVLSAAAMLECMKWLDEALDKI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000422	tail stripe
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR019135	Polycomb_protein_VEFS-Box

Vocabulary: **biological process**
Term	Definition
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0016569	covalent chromatin modification
GO:0016571	histone methylation
GO:0016574	histone ubiquitination
GO:0045596	negative regulation of cell differentiation

Vocabulary: **molecular function**
Term	Definition
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0035064	methylated histone binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:1990841	promoter-specific chromatin binding

Vocabulary: **cellular component**
Term	Definition
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0016586	RSC complex
GO:0016604	nuclear body
GO:0032993	protein-DNA complex
GO:0035098	ESC/E(Z) complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR019135	Polycomb protein, VEFS-Box	PFAM	PF09733	VEFS-Box	coord: 533..664 e-value: 1.9E-19 score: 69.8
None	No IPR available	PANTHER	PTHR22597	POLYCOMB GROUP PROTEIN	coord: 48..669
None	No IPR available	PANTHER	PTHR22597:SF0	POLYCOMB PROTEIN SUZ12	coord: 48..669

Main menu

SZ12-1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Owlery

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