Muscle associated receptor tyrosine kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001950 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 138.658 bits (348), Expect = 8.412e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 561 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 790
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 138.658 bits (348), Expect = 8.412e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 561 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 790
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 138.658 bits (348), Expect = 9.137e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 577 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 806
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 138.658 bits (348), Expect = 9.137e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 577 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 806
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 137.887 bits (346), Expect = 1.212e-32 Identity = 83/305 (27.21%), Postives = 140/305 (45.90%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
PF ++ K L + +A F +E ++++ ++PNI++ GVC K C + EY+ GD+ L RS+ + S S + ++ P P L+ + + ++ + YL + +HRD+ATRNCLVG N+ K++DF + N N+ IPIRW+P E++ + T++DVW +GV LWE+ S+G +PY EV + IL PENCP+E+Y M++C++ RP + L ++C++
Sbjct: 516 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFL--------------------------------RSMSPHTVCSLSHSDL-------SMRAQVSSPGPP---PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCER 776
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 114.775 bits (286), Expect = 3.056e-26 Identity = 62/164 (37.80%), Postives = 89/164 (54.27%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQ-RPCLDIVKNNLMKI 2962
L +QL+ + +IC + YL +K ++HRD+A RN L+ +L AK+SDF +K S D + + PI+W E L + F T +DVW FG+ LWE+ SFG+ PY + +V I +E PE CP EI++ M +A S Q RP V L I
Sbjct: 375 LERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHD---SASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 535
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 114.775 bits (286), Expect = 3.056e-26 Identity = 62/164 (37.80%), Postives = 89/164 (54.27%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQ-RPCLDIVKNNLMKI 2962
L +QL+ + +IC + YL +K ++HRD+A RN L+ +L AK+SDF +K S D + + PI+W E L + F T +DVW FG+ LWE+ SFG+ PY + +V I +E PE CP EI++ M +A S Q RP V L I
Sbjct: 375 LERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHD---SASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 535
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 115.546 bits (288), Expect = 3.153e-26 Identity = 62/164 (37.80%), Postives = 89/164 (54.27%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQ-RPCLDIVKNNLMKI 2962
L +QL+ + +IC + YL +K ++HRD+A RN L+ +L AK+SDF +K S D + + PI+W E L + F T +DVW FG+ LWE+ SFG+ PY + +V I +E PE CP EI++ M +A S Q RP V L I
Sbjct: 460 LERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHD---SASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 620
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6]) HSP 1 Score: 115.546 bits (288), Expect = 3.153e-26 Identity = 62/164 (37.80%), Postives = 89/164 (54.27%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQ-RPCLDIVKNNLMKI 2962
L +QL+ + +IC + YL +K ++HRD+A RN L+ +L AK+SDF +K S D + + PI+W E L + F T +DVW FG+ LWE+ SFG+ PY + +V I +E PE CP EI++ M +A S Q RP V L I
Sbjct: 460 LERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHD---SASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTI 620
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 114.005 bits (284), Expect = 1.732e-25 Identity = 57/150 (38.00%), Postives = 87/150 (58.00%), Query Frame = 2
Query: 2510 EICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPN-EYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS-RQRPCLDIVKNNL 2953
+I + YL + +HRD+ATRNCLVG K++DF + + SYG D + ++P+RW+ KE +E F+ +DVW FGV LWE+ SFG++PY +V E + + +LE P NCP IY M C+ + +RP +++ L
Sbjct: 550 QIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLM-RTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRL 698
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Match: Nrk (gene:FBgn0020391 transcript:FBtr0087728) HSP 1 Score: 131.339 bits (329), Expect = 5.345e-31 Identity = 77/279 (27.60%), Postives = 125/279 (44.80%), Query Frame = 2
Query: 2069 FAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L + +DQ + F +E +L++ +HPNI+R GVC + C + EY+ GD+ L R P +++ A Q R + L L+Q I ++YL + +HRD+ATRNCL+ ++ K++DF K G+ N++IPIRW+P E++ F+ ++DVW +G+ LWE+ SF +PY EV + I +L P+N PL +Y M+ C+
Sbjct: 471 LVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVC--ALGRPMCLLFEYMAPGDLSEFL---RACSPYATHQ----------------------------------------APTQDR----------LQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCW 694
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Match: Ror (gene:FBgn0010407 transcript:FBtr0079978) HSP 1 Score: 122.094 bits (305), Expect = 4.642e-28 Identity = 60/166 (36.14%), Postives = 87/166 (52.41%), Query Frame = 2
Query: 2459 PAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF-APSRQRPCLDIVKNNL 2953
P E L+ + +Q +I + + YL H +HRD+A RNCLV L K+SDF + +P+RW+P E++ F T++DVW FGV LWE+ S+G +PY + EV I S ++L PENCP +Y M C+ S +RP + N L
Sbjct: 505 PTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRL 670
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290232) HSP 1 Score: 122.865 bits (307), Expect = 7.262e-28 Identity = 75/299 (25.08%), Postives = 129/299 (43.14%), Query Frame = 2
Query: 2051 PSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPC-LDIV 2941
P+G IK +N D++ F E ++ + + +++R GVC + ++E + GD+KS L R E + + N T ++ P TY ++ Q EI D + YL K +HRD+A RNC+V +L K+ DF + +P+RW+P E+L + ++++ +DV+ FGV LWE+ + +PY +V ++ ++E PENCP +++ M+ C+ S RP LDI+
Sbjct: 1395 PNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPE------------------------------------ERDEAMMTYLNRIGVTGNVQPP--------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDII 1647
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290230) HSP 1 Score: 122.865 bits (307), Expect = 7.262e-28 Identity = 75/299 (25.08%), Postives = 129/299 (43.14%), Query Frame = 2
Query: 2051 PSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPC-LDIV 2941
P+G IK +N D++ F E ++ + + +++R GVC + ++E + GD+KS L R E + + N T ++ P TY ++ Q EI D + YL K +HRD+A RNC+V +L K+ DF + +P+RW+P E+L + ++++ +DV+ FGV LWE+ + +PY +V ++ ++E PENCP +++ M+ C+ S RP LDI+
Sbjct: 1395 PNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPE------------------------------------ERDEAMMTYLNRIGVTGNVQPP--------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDII 1647
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0084121) HSP 1 Score: 122.865 bits (307), Expect = 7.262e-28 Identity = 75/299 (25.08%), Postives = 129/299 (43.14%), Query Frame = 2
Query: 2051 PSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPC-LDIV 2941
P+G IK +N D++ F E ++ + + +++R GVC + ++E + GD+KS L R E + + N T ++ P TY ++ Q EI D + YL K +HRD+A RNC+V +L K+ DF + +P+RW+P E+L + ++++ +DV+ FGV LWE+ + +PY +V ++ ++E PENCP +++ M+ C+ S RP LDI+
Sbjct: 1395 PNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPE------------------------------------ERDEAMMTYLNRIGVTGNVQPP--------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDII 1647
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Match: ntrk2b (neurotrophic tyrosine kinase, receptor, type 2b [Source:ZFIN;Acc:ZDB-GENE-010126-2]) HSP 1 Score: 139.428 bits (350), Expect = 3.318e-33 Identity = 82/287 (28.57%), Postives = 140/287 (48.78%), Query Frame = 2
Query: 2048 SPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
SP +K L A ++ A F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + + +G Q++ ++LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 536 SPDQEKILVAVKTLKEA-SESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIM--VFEYMKHGDLNKFL---RAHGPDAV------LMADGQQSLL------------------------------------------VELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 767
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Match: ntrk2b (neurotrophic tyrosine kinase, receptor, type 2b [Source:ZFIN;Acc:ZDB-GENE-010126-2]) HSP 1 Score: 136.732 bits (343), Expect = 2.110e-32 Identity = 83/289 (28.72%), Postives = 138/289 (47.75%), Query Frame = 2
Query: 2048 SPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSF---VQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
SP +K L A ++ A F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + + +G Q++ ++LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF V Y +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 536 SPDQEKILVAVKTLKEA-SESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIM--VFEYMKHGDLNKFL---RAHGPDAV------LMADGQQSLL------------------------------------------VELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVSVGG-HTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 769
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Match: musk (muscle, skeletal, receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030131-6458]) HSP 1 Score: 135.576 bits (340), Expect = 6.851e-32 Identity = 86/306 (28.10%), Postives = 141/306 (46.08%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDKL 2974
PF ++ K L + + F +E ++S+ +HPNI+R GVC K C + EY+ GD+ L RR + S+ D+ SS + E ER P L+ ++ + ++ + YL + +HRD+ATRNCLV NL K++DF + + N+ IPIRW+P E++ + +++DVW +GV LWE+ S+G +PY EV + +L PENCP E+Y M++C++ RP + L ++ D++
Sbjct: 673 PFTMVAVKMLKEEASTDMQNDFQREAALMSEFDHPNIVRLLGVC--AVGKPMCLMFEYMAYGDLNEFL---RRR---------------------CATQQPSLSRDTLTSS------------SLVSEPERYPP-----LSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNVLSCPENCPQELYNLMRLCWSGHPTDRPSFASIHRILERMHDQM 935
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Match: musk (muscle, skeletal, receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030131-6458]) HSP 1 Score: 135.191 bits (339), Expect = 8.213e-32 Identity = 86/306 (28.10%), Postives = 141/306 (46.08%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDKL 2974
PF ++ K L + + F +E ++S+ +HPNI+R GVC K C + EY+ GD+ L RR + S+ D+ SS + E ER P L+ ++ + ++ + YL + +HRD+ATRNCLV NL K++DF + + N+ IPIRW+P E++ + +++DVW +GV LWE+ S+G +PY EV + +L PENCP E+Y M++C++ RP + L ++ D++
Sbjct: 673 PFTMVAVKMLKEEASTDMQNDFQREAALMSEFDHPNIVRLLGVC--AVGKPMCLMFEYMAYGDLNEFL---RRR---------------------CATQQPSLSRDTLTSS------------SLVSEPERYPP-----LSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNVLSCPENCPQELYNLMRLCWSGHPTDRPSFASIHRILERMHDQM 935
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Match: ntrk3a (neurotrophic tyrosine kinase, receptor, type 3a [Source:ZFIN;Acc:ZDB-GENE-010126-3]) HSP 1 Score: 132.109 bits (331), Expect = 6.084e-31 Identity = 77/262 (29.39%), Postives = 127/262 (48.47%), Query Frame = 2
Query: 2123 FNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
F +E ++L+ + H +I++FYGVC + + EY+ +GD+ L R P + L + ++T N +L Q++ +I +VYL ++H +HRD+ATRNCLVG L K+ DF + +S + +G + +PIRW+P E++ F T++DVW FGV LWE+ ++GK+P+ + +EV E I ++LE P CP E+Y+ M C+
Sbjct: 578 FQREAELLTNLQHEHIVKFYGVC--VDGDPLIMVFEYMKHGDLNKFL---RAHGPDA----------------MILVDGQPLQT-------------------------------NGELGLSQMLHIASQIASGMVYLGSQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLANNEVIECITQGRVLERPRLCPKEVYDIMLGCW 786
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 140.198 bits (352), Expect = 7.291e-34 Identity = 84/281 (29.89%), Postives = 137/281 (48.75%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 354 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVC--VEGDPLIMVFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 576
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 140.198 bits (352), Expect = 2.138e-33 Identity = 84/281 (29.89%), Postives = 138/281 (49.11%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 553 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 775
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 140.198 bits (352), Expect = 2.341e-33 Identity = 84/281 (29.89%), Postives = 138/281 (49.11%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 567 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 789
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 139.428 bits (350), Expect = 3.107e-33 Identity = 84/281 (29.89%), Postives = 138/281 (49.11%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 501 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 723
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 139.813 bits (351), Expect = 3.323e-33 Identity = 84/281 (29.89%), Postives = 138/281 (49.11%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 530 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 752
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Match: Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2 [Source:MGI Symbol;Acc:MGI:97384]) HSP 1 Score: 139.043 bits (349), Expect = 4.752e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 560 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 789
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Match: Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2 [Source:MGI Symbol;Acc:MGI:97384]) HSP 1 Score: 139.043 bits (349), Expect = 4.752e-33 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 560 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 789
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 136.732 bits (343), Expect = 2.579e-32 Identity = 86/305 (28.20%), Postives = 142/305 (46.56%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
PF ++ K L + +A F +E ++++ ++PNI++ GVC K C + EY+ GD+ L R P TV +L S + S + R + P P L+ + + ++ + YL + +HRD+ATRNCLVG + K++DF + + N+ IPIRW+P E++ + T++DVW +GV LWE+ S+G +PY EV + IL PENCPLE+Y M++C++ RP + L ++C++
Sbjct: 603 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFL---RSMSP---------------HTVCSLSHS--------------------DLSTRAR-VSSPGPP---PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCER 863
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 136.732 bits (343), Expect = 2.837e-32 Identity = 86/305 (28.20%), Postives = 142/305 (46.56%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
PF ++ K L + +A F +E ++++ ++PNI++ GVC K C + EY+ GD+ L R P TV +L S + S + R + P P L+ + + ++ + YL + +HRD+ATRNCLVG + K++DF + + N+ IPIRW+P E++ + T++DVW +GV LWE+ S+G +PY EV + IL PENCPLE+Y M++C++ RP + L ++C++
Sbjct: 603 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFL---RSMSP---------------HTVCSLSHS--------------------DLSTRAR-VSSPGPPP---LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCER 863
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 136.732 bits (343), Expect = 2.993e-32 Identity = 86/305 (28.20%), Postives = 142/305 (46.56%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
PF ++ K L + +A F +E ++++ ++PNI++ GVC K C + EY+ GD+ L R P TV +L S + S + R + P P L+ + + ++ + YL + +HRD+ATRNCLVG + K++DF + + N+ IPIRW+P E++ + T++DVW +GV LWE+ S+G +PY EV + IL PENCPLE+Y M++C++ RP + L ++C++
Sbjct: 611 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFL---RSMSP---------------HTVCSLSHS--------------------DLSTRAR-VSSPGPPP---LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCER 871
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q91987|NTRK2_CHICK (BDNF/NT-3 growth factors receptor OS=Gallus gallus OX=9031 GN=NTRK2 PE=1 SV=1) HSP 1 Score: 140.198 bits (352), Expect = 1.250e-32 Identity = 86/288 (29.86%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ L R P + N+ PAE LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 557 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDLNKFL---RAHGPDAVLMAEGNR-----------------------------------------------PAE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 786
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Match: sp|P15209|NTRK2_MOUSE (BDNF/NT-3 growth factors receptor OS=Mus musculus OX=10090 GN=Ntrk2 PE=1 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 3.324e-32 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 560 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 789
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q63604|NTRK2_RAT (BDNF/NT-3 growth factors receptor OS=Rattus norvegicus OX=10116 GN=Ntrk2 PE=1 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 3.503e-32 Identity = 83/281 (29.54%), Postives = 138/281 (49.11%), Query Frame = 2
Query: 2069 FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 567 LVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 789
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q16620|NTRK2_HUMAN (BDNF/NT-3 growth factors receptor OS=Homo sapiens OX=9606 GN=NTRK2 PE=1 SV=1) HSP 1 Score: 138.658 bits (348), Expect = 4.040e-32 Identity = 85/288 (29.51%), Postives = 140/288 (48.61%), Query Frame = 2
Query: 2063 CP-----FAVIKYLNNA-DNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
CP +K L +A DN +K+ F++E ++L+ + H +I++FYGVC+ + + EY+ +GD+ +KF + + + E P E LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+YE M C+
Sbjct: 561 CPEQDKILVAVKTLKDASDNARKD--FHREAELLTNLQHEHIVKFYGVCVEGDPLIM--VFEYMKHGDL-------------------------------------------------NKFLR-AHGPDAVLMAEGNPPTE---LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCW 790
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q62838|MUSK_RAT (Muscle, skeletal receptor tyrosine protein kinase OS=Rattus norvegicus OX=10116 GN=Musk PE=1 SV=1) HSP 1 Score: 138.272 bits (347), Expect = 5.658e-32 Identity = 87/305 (28.52%), Postives = 143/305 (46.89%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
PF ++ K L + +A F +E ++++ ++PNI++ GVC K C + EY+ GD+ L R P TV +L S + S + R + P P L+ + + ++ + YL + +HRD+ATRNCLVG N+ K++DF + + N+ IPIRW+P E++ + T++DVW +GV LWE+ S+G +PY EV + IL PENCPLE+Y M++C++ RP + L ++C++
Sbjct: 601 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFL---RSMSP---------------HTVCSLSHS--------------------DLSTRAR-VSSPGPP---PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCER 861
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Match: A0A4E0R3A2 (Tyrosine-protein kinase transmembrane receptor Ror2 OS=Fasciola hepatica OX=6192 GN=D915_008445 PE=4 SV=1) HSP 1 Score: 172.17 bits (435), Expect = 5.431e-44 Identity = 99/300 (33.00%), Postives = 154/300 (51.33%), Query Frame = 2
Query: 2087 LNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSIL-------TGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSR-QRPCLDIVKNNLMKI 2962
LN+ + + A F +E ++L +++H NI+ GVC + + I+EY+P GD+ ++L + P + +N + + V SV D K+ A ++ + P +N LT QL+ + CDA+VYL ++ +HRD+A R+ LVG KLSDFS + DL+ PNEY+P++WLP E+ N +F+ DTDVW FGV+LWEL SFG EPY +V + + K L P +CP +YE M C++ R +RP ++ +L I
Sbjct: 2 LNDDADLETHANFLREAEVLVELSHKNIIELLGVC--VPLRPPSLILEYMPYGDLTTLLRHYGAPDSCGPVSPLHFTGVPDNMPLAANGELVSLTHTKDSVVCD-----------KYDEAGSRYSNLRSWVPPKN--LTCHQLLCMALDACDAMVYLSDRYYVHRDVAARSFLVGNRFILKLSDFSLCRPIKPHVDLVAKPNEYLPVKWLPVESTVNGVFHIDTDVWAFGVFLWELFSFGSEPYDSLSCDQVVPFLEAGKRLVRPADCPSPVYELMLRCWSAERSERPSFSEIRTHLHTI 286
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Match: A0A504YL47 (Tyrosine-protein kinase transmembrane receptor Ror OS=Fasciola gigantica OX=46835 GN=FGIG_05715 PE=4 SV=1) HSP 1 Score: 178.333 bits (451), Expect = 1.328e-41 Identity = 101/307 (32.90%), Postives = 158/307 (51.47%), Query Frame = 2
Query: 2066 PFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSIL-------TGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSR-QRPCLDIVKNNLMKI 2962
P V+K LN+ + + A F +E ++L +++H NI+ GVC+ + + ++EY+P GD+ ++L + P + +N + + V V D K+ A ++ + P +N LT QL+ + CDA+VYL +H +HRD+A R+ LVG KLSDFS + DLI P+EY+P++WLP E+ N +F+ DTDVW FGV+LWEL SFG EPY +V + + K L P +CP +YE M C++ R +RP ++ +L I
Sbjct: 1138 PLVVVKMLNDDADLETHANFLREAEVLVELSHKNIIELLGVCVPL--RPPSLLLEYMPYGDLITLLRHYGVPDSCGPVSPLHFTGVPDNMPLTANGELVSLTHTKDPVVCD-----------KYDEAGSRYSNLRSWAPPKN--LTCHQLLCMALDACDAMVYLSDRHYVHRDVAARSFLVGNRFILKLSDFSLCRPIKPHVDLIAKPDEYLPVKWLPVESTVNGVFHIDTDVWAFGVFLWELFSFGSEPYDSLSCDQVVPFLEAGKRLVRPADCPPPVYELMLRCWSAERSERPSFSEIRTHLHTI 1429
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Match: A0A3P7X608 (Protein kinase domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS220 PE=4 SV=1) HSP 1 Score: 166.007 bits (419), Expect = 1.012e-38 Identity = 132/416 (31.73%), Postives = 186/416 (44.71%), Query Frame = 2
Query: 1727 LFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKGFNS--NSERLQPNKRPRSARXXXXXXXXXXXXXXXXVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGY-QTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSR-QRPCLDIVKNNLMKI 2962
LF H L+ F+ Y ++ LA +G I+LV A N + LV + S SERL V + EK SS + AV+K + N + EA F +E +IL ++ H NI++ GVC+ + ++EY+P GD S L E P S N +I + Y QT+ LQ + K D N E P +L K L + + C+A+VYL H +HRD+ATR+ LVG L KLSDFS + G D I NE +PI+WLP E++ F+TDTDVW FGV LWE+ SF EP+ E+ + + L P CP IY+ M C++ R +RP ++N L +I
Sbjct: 316 LFNVASMNHLLHPKFKSLCYPRNRLVEICCLAKRAFGWIILVHA--PNLNKLVHRRRLLSLTTSERLG------------------------LVSSSSQEKENIDVQSSSDESNNCIAVLKMIQGGSNLKAEANFLREAEILVELQHRNIMQLLGVCIPLEP--LSLLIEYMPFGDFYSFLRRYTGESPGYST--VNGEIVHSYSQTL--LQTTTVPKKDFIN--------------------EYPT-----NLNVKILTEMVIDACEAMVYLSELHYVHRDVATRSFLVGKKLIVKLSDFSMCRPIQPGVDFISTSNECLPIKWLPLESILEGKFHTDTDVWSFGVLLWEVFSFAVEPFTNLSHSEIIKLLEHGDRLTRPSQCPESIYQLMLKCWSADRTERPKFIYIRNCLKEI 674
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Match: A0A183NDN4 (Protein kinase domain-containing protein OS=Schistosoma mattheei OX=31246 PE=4 SV=1) HSP 1 Score: 165.622 bits (418), Expect = 1.149e-38 Identity = 132/416 (31.73%), Postives = 186/416 (44.71%), Query Frame = 2
Query: 1727 LFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKGFNS--NSERLQPNKRPRSARXXXXXXXXXXXXXXXXVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGY-QTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSR-QRPCLDIVKNNLMKI 2962
LF H L+ F+ Y ++ LA +G I+LV A N + LV + S SERL V + EK SS + AV+K + N + EA F +E +IL ++ H NI++ GVC+ + ++EY+P GD S L E P S N +I + Y QT+ LQ + K D N E P +L K L + + C+A+VYL H +HRD+ATR+ LVG L KLSDFS + G D I NE +PI+WLP E++ F+TDTDVW FGV LWE+ SF EP+ E+ + + L P CP IY+ M C++ R +RP ++N L +I
Sbjct: 316 LFNVASMNHLLHPKFKSLCYPRNRLVEICCLAKRAFGWIILVHA--PNLNKLVHRRRLLSLTTSERLG------------------------LVSSSSQEKENIDVQSSSDESNNCIAVLKMIQGGSNLKAEANFLREAEILVELQHRNIMQLLGVCIPLEP--LSLLIEYMPFGDFYSFLRRYTGESPGYST--VNGEIVHSYSQTL--LQTTTVPKKDFIN--------------------EYPT-----NLNVKILTEMVIDACEAMVYLSELHYVHRDVATRSFLVGKKLIVKLSDFSMCRPIQPGVDFISTSNECLPIKWLPLESILEGKFHTDTDVWSFGVLLWEVFSFAVEPFTNLSHSEIIKLLEHGDRLTRPSQCPESIYQLMLKCWSADRTERPKFIYIRNCLKEI 674
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Match: A0A068WGC2 (Tyrosine protein kinase transmembrane receptor OS=Echinococcus granulosus OX=6210 GN=EgrG_000445100 PE=4 SV=1) HSP 1 Score: 166.777 bits (421), Expect = 3.635e-38 Identity = 95/304 (31.25%), Postives = 154/304 (50.66%), Query Frame = 2
Query: 2066 PFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPA---ENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSY--GFDLIGNPNEY-IPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSR-QRPCLDIVKNNLM 2956
P+ VIK LN E F +E ++L +++HPNI+R G+C+ + I EY+ +GD+ + L +R H S+ F N + + ++ A + L L+++ +C+A++YL K +HRD+ATRNCLV + KL+DFS ++ + DL+ +E + +RWLP E++ FN DTDVW FGV LWEL +FG+ PY ++ EV A+ ++ L P++CP IY M+ C++P+R QRP +K++L+
Sbjct: 837 PYVVIKTLNFGATPAAETSFFREAELLIELDHPNIVRIIGICIPLQPYSL--IYEYMRDGDLNTFL-----------------------------HHARDAAASPHTSATNELAFSVINDDDTGSDADKASTAFVANDEALPTPTLLRFALGVCEAMIYLSGKLYVHRDLATRNCLVNGS-HVKLADFSMCRRLPHNCAADLVDTDSEAPLAVRWLPLESILQGHFNVDTDVWSFGVLLWELFTFGQMPYGNVEVSEVIRALTENRRLPRPDHCPPSIYRLMQKCWSPTREQRPSFREIKSSLL 1108
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Match: ntrk2b (BDNF/NT-3 growth factors receptor-like [Source:NCBI gene;Acc:103044160]) HSP 1 Score: 139.043 bits (349), Expect = 3.362e-33 Identity = 82/287 (28.57%), Postives = 139/287 (48.43%), Query Frame = 2
Query: 2048 SPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
SP +K L A ++ A F++E ++L+ + H +I+ FYGVC+ + + EY+ +GD+ L R P + + +G Q++ ++LT Q++ +I +VYL ++H +HRD+ATRNCLVG NL K+ DF + +S + +G + +PIRW+P E++ F T++DVW GV LWE+ ++GK+P+ + +EV E I ++L+ P CP E+Y+ M C+
Sbjct: 550 SPDQEKILVAVKTLKEA-SESGRADFHREAELLTNLQHEHIVTFYGVCVESDPLIM--VFEYMKHGDLNKFL---RAHGPDAV------LMADGQQSML------------------------------------------VELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCW 781
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 137.117 bits (344), Expect = 7.641e-33 Identity = 82/283 (28.98%), Postives = 133/283 (47.00%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI+R GVC K C + EY+ +GD+ L RR P + + S+ TD +SE P P L+ + + ++ + YL + +HRD+ATRNCLVG +L K++DF + + N+ IPIRW+P E++ + +++DVW +GV LWE+ S G +PY EV + +L PENCPLE+Y M++C++
Sbjct: 417 PFTMVAVKMLKEEASADMQNDFQREAALMAEFDHPNIVRLLGVC--AVGKPMCLMFEYMAHGDLNEFLR--RRSPAQQRS------------------LSQGSLTDQSFASESD-----------------PTP-----LSCLEKLSMSKQVAAGMAYLSERKFVHRDLATRNCLVGEDLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSHGMQPYYGMAHEEVIYYVRDGHVLACPENCPLELYNLMRLCWS 655
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 137.117 bits (344), Expect = 1.449e-32 Identity = 82/283 (28.98%), Postives = 133/283 (47.00%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI+R GVC K C + EY+ +GD+ L RR P + + S+ TD +SE P P L+ + + ++ + YL + +HRD+ATRNCLVG +L K++DF + + N+ IPIRW+P E++ + +++DVW +GV LWE+ S G +PY EV + +L PENCPLE+Y M++C++
Sbjct: 594 PFTMVAVKMLKEEASADMQNDFQREAALMAEFDHPNIVRLLGVC--AVGKPMCLMFEYMAHGDLNEFLR--RRSPAQQRS------------------LSQGSLTDQSFASESD-----------------PTP-----LSCLEKLSMSKQVAAGMAYLSERKFVHRDLATRNCLVGEDLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSHGMQPYYGMAHEEVIYYVRDGHVLACPENCPLELYNLMRLCWS 832
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 137.502 bits (345), Expect = 1.467e-32 Identity = 82/283 (28.98%), Postives = 133/283 (47.00%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI+R GVC K C + EY+ +GD+ L RR P + + S+ TD +SE P P L+ + + ++ + YL + +HRD+ATRNCLVG +L K++DF + + N+ IPIRW+P E++ + +++DVW +GV LWE+ S G +PY EV + +L PENCPLE+Y M++C++
Sbjct: 643 PFTMVAVKMLKEEASADMQNDFQREAALMAEFDHPNIVRLLGVC--AVGKPMCLMFEYMAHGDLNEFLR--RRSPAQQRS------------------LSQGSLTDQSFASESD-----------------PTP-----LSCLEKLSMSKQVAAGMAYLSERKFVHRDLATRNCLVGEDLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSHGMQPYYGMAHEEVIYYVRDGHVLACPENCPLELYNLMRLCWS 881
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Match: ntrk3b (neurotrophic receptor tyrosine kinase 3 [Source:NCBI gene;Acc:103046759]) HSP 1 Score: 133.265 bits (334), Expect = 2.033e-31 Identity = 76/268 (28.36%), Postives = 128/268 (47.76%), Query Frame = 2
Query: 2123 FNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQR 2923
F +E ++L+ + H +I++FYGVC + + EY+ +GD+ L R P + + D H N +L Q++ +I +VYL ++H +HRD+ATRNCLVG L K+ DF + +S + +G + +PIRW+P E++ F+T++DVW FGV LWE+ ++GK+P+ + +EV E + ++L+ P CP E+Y+ M C+ Q+
Sbjct: 581 FQREAELLTNLQHDHIVKFYGVC--VDSDPLIMVFEYMKHGDLNKFL---RAHGPDGT-----------------------ILVDGHPMQS------------------------NGELGLSQMLHVATQIAAGMVYLSSQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSMDYYRVGG-HTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGKQPWFQLSNNEVIEYVTQGRVLDRPRLCPKEVYDLMLGCWQSEPQQ 795
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 135.961 bits (341), Expect = 4.368e-36 Identity = 82/288 (28.47%), Postives = 132/288 (45.83%), Query Frame = 2
Query: 2114 EARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS-RQRPCLDIVKNNLMKICDKL 2974
+A F++E ++++ HPNI++ GVC K C + E++P+GD+ L RR S E+ AS+ +E + L + ++ + YL + +HRD+ATRNCLVG L K+SDF Q N N+ IPIRW+P E++ + +++DVW FGV LWE+ S G +PY EV + +L P+ CPL++Y M++C+A + RP V++ L ++ +L
Sbjct: 5 QANFHREAALMAEFTHPNIVKLLGVC--AVGKPFCLLFEFMPHGDLNEYL---RR------------------------------------CSSEAGL----AASSPPARAPTSSGSEPVSLCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKANENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGNVLACPDGCPLDLYNLMRLCWAHAPADRPSFASVQHVLARMHAQL 247
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 139.043 bits (349), Expect = 6.695e-36 Identity = 79/269 (29.37%), Postives = 130/269 (48.33%), Query Frame = 2
Query: 2102 NDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF 2905
+D F +E ++L+ + H +I+RFYGVC + + + EY+ NGD+ +KF + + + + PQ AE L+ Q++ G +I + YL ++H +HRD+ATRNCLVG L K+ DF + +S + +G + +PIRW+P E++ F D+DVW GV LWE+ ++GK+P+ + EV + I ++LE P +CP+E+YE M C+
Sbjct: 116 SDGARKDFYREAELLTNLQHEHIVRFYGVC--VEGEPLIMVFEYMKNGDL-------------------------------------------------NKFLRLRG-PDAVFMGDAPQ-AEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVYSTDYYRVGG-HTMLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRVLERPRSCPMEVYELMLGCW 330
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009736.1 (pep scaffold:Pmarinus_7.0:GL479388:5844:12989:-1 gene:ENSPMAG00000008798.1 transcript:ENSPMAT00000009736.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 102.449 bits (254), Expect = 1.215e-24 Identity = 48/147 (32.65%), Postives = 82/147 (55.78%), Query Frame = 2
Query: 2480 TYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF--SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS 2914
T K L+ +G ++ + YL +K +HRD+A RNC++ + K++DF + + + + +PI+W+ E+L+ F T +DVW FGV LWEL + G PY + D ++ + + L PE CP E++E+M C+ P+
Sbjct: 63 TVKDLIGFGLQVARGMEYLASKKFVHRDLAARNCMLDESYTVKVADFGLARDIYNKEYYSIRNHQRAKLPIKWIALESLQTQRFTTKSDVWSFGVLLWELQTRGAPPYPDVDPFDMARFLRQGRRLPQPEYCPDELFERMLDCWGPT 209
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 103.605 bits (257), Expect = 2.599e-24 Identity = 71/296 (23.99%), Postives = 129/296 (43.58%), Query Frame = 2
Query: 2072 AVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNE-YIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS-RQRPCLDIVKNNL 2953
IK +N ++ F E ++ N +++R GV + I+E + GD+KS L RS++ D+ + +E E + +P ++ +++Q EI D + YL+ K +HRD+A RNC+V + K+ DF + Y D + +P+RW+ E+L++ +F T +DVW FGV LWE+ + ++PY +V + ++ +L +P CP + E ++ C+ + R RP + + L
Sbjct: 44 VAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQAQPILV--IMELMTRGDLKSYL--------------------------------RSLRPDAEDFTE-----------TIVLEKKPTRPPSSL----PEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEILDGL 289
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008763.1 (pep scaffold:Pmarinus_7.0:GL480478:1796:23946:1 gene:ENSPMAG00000007909.1 transcript:ENSPMAT00000008763.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 106.301 bits (264), Expect = 2.943e-24 Identity = 70/266 (26.32%), Postives = 114/266 (42.86%), Query Frame = 2
Query: 2075 VIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQ-TREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENC 2869
+K L + + E +L Q+NHPNI+R +G C + IVEY G ++S L R+ +A+ ASN+ +R ++ P + LT LV + ++I + YL L+HRD+A RN LV + K+SDF + G + IP++W+ E+L ++ + +DVW FG+ LWE+M+ G PY ++ + + +E PENC
Sbjct: 240 AVKMLKECASHSELRDLLSELNLLKQVNHPNIIRLHGACTQDEGPLY-LIVEYAKYGSLRSFLRVRRKAE-------------------FAVPAG--------------------GASNRNSRLLDNP---DERGLTLGDLVSFAWQISRGMTYLADMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEGDSYVKRTKGRIPVKWMAIESLFEHMYTSQSDVWSFGILLWEIMTLGGTPYPGIPPERLFNLLKTGYRMEKPENC 462
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 72.4034 bits (176), Expect = 2.406e-13 Identity = 45/160 (28.12%), Postives = 73/160 (45.62%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSF----VQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKI--LEIPENCPLEIYEQMKMCFAPSRQRPCLDI 2938
LT Q+ E C + +LH KH+IHRDI + N L+ K++DF F K S ++G P W+ E ++ ++ DVW G+ E++ G+ PY D + I ++ L+ PE+ LEI + +C C+D+
Sbjct: 665 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTP------YWMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCL-------CVDV 810
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 61.6178 bits (148), Expect = 2.567e-10 Identity = 32/117 (27.35%), Postives = 63/117 (53.85%), Query Frame = 2
Query: 2501 WGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKI 2848
+ E+C A+ YLH+K +I+RD+ N L+ N K++DF F + + L G P+ ++ E + +N D W FG+ ++E+++ G P+ + + + YE I++ ++
Sbjct: 190 YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPD------YIAPEVVSTKPYNKSIDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNAEL 299
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 62.003 bits (149), Expect = 3.526e-10 Identity = 35/123 (28.46%), Postives = 59/123 (47.97%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFS----YGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAI 2833
LT ++ + +IC AI Y+H++ +IHRD+ N N K+ DF + + + G PN P + K + + + D+W GV L+ L+ GK P+ D++ +YE I
Sbjct: 176 LTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSF----EVDIWSLGVMLYALL-IGKPPFQARDVNTIYERI 293
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 61.2326 bits (147), Expect = 3.537e-10 Identity = 34/117 (29.06%), Postives = 61/117 (52.14%), Query Frame = 2
Query: 2501 WGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKF-SYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKI 2848
+ E+C A+ YLH+K +I+RD+ N L+ N K++DF F + + L G P+ P E + +N D W FGV ++E+++ G P+ + + YE I++ ++
Sbjct: 191 YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAP------EVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPFYNSNTMKTYENILNAEL 300
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130]) HSP 1 Score: 58.5362 bits (140), Expect = 2.010e-9 Identity = 39/126 (30.95%), Postives = 63/126 (50.00%), Query Frame = 2
Query: 2507 FEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYI-----PIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENC 2869
++I +A+ Y+H K++IHRDI N L+G N KL+DF G+ +I P I +L E +E+ ++ D W GV +EL++ G P+ E Y+ I + I ++P N
Sbjct: 209 YQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDF--------GWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLT-GAPPFEEEMKDTTYKRIAALDI-KMPSNI 324
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 114.005 bits (284), Expect = 1.000e-27 Identity = 55/172 (31.98%), Postives = 93/172 (54.07%), Query Frame = 2
Query: 2435 TREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNE-YIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMC--FAPSRQRPCLDIV 2941
T E + P P T +Q++Q EI D + YL + +HRD+A RNC+V NL K+ DF + Y D + +P+RW+ E+L++ +F + +DVW FGV +WE+ + +PY EV + +V ++ P++CP +++ M +C F+P + L I+
Sbjct: 118 TMESDEPPP------TLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPDDCPDRLFDLMTLCWQFSPKARPTFLSII 282
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Match: EDO35594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SL46]) HSP 1 Score: 107.457 bits (267), Expect = 5.401e-26 Identity = 75/284 (26.41%), Postives = 126/284 (44.37%), Query Frame = 2
Query: 2087 LNNADNDQKEARFNKETKILSQM-NHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS-RQRPCL 2932
++ A +Q E F KE ++ ++ +H NI+ F +C K+ +VE+LP GD+ L +++RS + D E+ E+ PQ L+ + ++I + YL K +HRD+A RN LV N + K++DF + G+ N +PI+W+ E + + IF T++DVW +GV LWE+ + G PY +V+ + S +E P+ C E+Y MK C+ ++RP
Sbjct: 3 VDTAGPEQGE-EFLKEISLMKKLGSHKNIVNF--LCCSTVKEPFMLVVEFLPKGDLLDYL-----------------------------RRNRSKQNDETGEQED--------------EMITPQ----------DLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLTRDLYEESAYQGHSNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTISTRDVFVMLRSGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTF 230
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Match: EDO44445 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVU0]) HSP 1 Score: 108.612 bits (270), Expect = 1.563e-25 Identity = 75/283 (26.50%), Postives = 127/283 (44.88%), Query Frame = 2
Query: 2132 ETKILSQMN-HPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDL-IGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAP-SRQRPCLDIVKNNLMKICDK 2971
E KIL + H NI+ G C + + I+E+ P G++ S L RRE YQ W +N P +N L L +++ + +L ++ +HRD+A RN LVG + K+SDF + Y DL + N + +P++W+ E+L + ++ +DVW FG+ LWE+M+ G PY ++ + + + + P+NCPLEIY M+ C+ QRP +++ + L K+ ++
Sbjct: 93 ELKILIHLGEHKNIVNVLGACTRGRRLMV--IIEFAPYGNLLSFLR-ARREV---------------YQPT------------------------WTKTTND--------PEKNYTLV--DLTMASYQVSRGVEFLASRKCVHRDLAARNVLVGPDYVMKVSDFGLARDI-YQDDLYVKNTSGLLPVKWMALESLFDRVYTEKSDVWSFGILLWEIMTLGGTPYPGLPTEQLLDYLSEGQRMAQPQNCPLEIYTIMRDCWMQLPEQRPHFNVLADRLGKVLER 322
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Match: EDO44269 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW90]) HSP 1 Score: 105.531 bits (262), Expect = 3.227e-25 Identity = 75/272 (27.57%), Postives = 112/272 (41.18%), Query Frame = 2
Query: 2123 FNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKE-PYCEYDLHEVYEAIV-------SDKI--LEIPENCPLEIYEQMKMCFA 2908
F KE KI++ + H N++R GVC C IVEY+ NGD+ L ++ S N + NK+ ALQ + +K Y+ + +HRD+ATRNCLVG + K++DF + +PIRW+ E + F + +DVW FGV LWE+++ E PY + +V E + SD I L PE CP ++Y +M+ C+A
Sbjct: 14 FFKEVKIMAGVRHENVVRLLGVC---KDDPMCMIVEYMENGDLNQFL---KQRELASGNSADPNKVTYQALLYMALQLAAGMK-----------------------------------------------------YIASHQFVHRDLATRNCLVGHSFTVKIADFGMSRHLYSKHYYRIQGRVILPIRWMAPECILQGKFTSASDVWAFGVTLWEILTLAAEYPYGDLTDEKVIENVQLMFFRPKSDAITFLSRPEICPPDVYAKMRSCWA 226
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91]) HSP 1 Score: 105.531 bits (262), Expect = 9.418e-25 Identity = 55/174 (31.61%), Postives = 91/174 (52.30%), Query Frame = 2
Query: 2456 QPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPS-RQRPCLDIVKNNLMKICDKL 2974
+P E LT LV F++ A+ +L ++ +HRD+A RN LVG N K++DF + + +P++W+ E L + ++ +DVW FGV LWE+ + G PY +EVY+ ++ + + PE+CP E+Y+ M C+ QRP L++ DK+
Sbjct: 127 KPDETFTLT--DLVITSFQVSRAMQFLASRRCVHRDLAARNVLVGENYVMKIADFGLARDIYKEEHYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTF----TQLLETIDKI 294
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Match: MUSK (muscle associated receptor tyrosine kinase [Source:NCBI gene;Acc:101164489]) HSP 1 Score: 141.354 bits (355), Expect = 4.569e-34 Identity = 84/283 (29.68%), Postives = 130/283 (45.94%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI++ GVC K C + EY+ NGD+ L RR P S H S+ S +S E+ L+ Q + +I + YL + +HRD+ATRNCLVG + K++DF + N N+ IPIRW+P E++ + ++DVW +GV LWE+ S G +PY EV + +IL PENCPLE+Y M++C++
Sbjct: 428 PFTMVAVKMLKEEASPDMQNDFQREAALMAEFDHPNIVKLLGVC--AVGKPMCLLFEYMANGDLNEFL---RRHSPTQSMHT---------------LSCPSISNRSFSSDMEAG-----------------------SLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGQILACPENCPLELYNLMRLCWS 667
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Match: MUSK (muscle associated receptor tyrosine kinase [Source:NCBI gene;Acc:101164489]) HSP 1 Score: 141.354 bits (355), Expect = 4.569e-34 Identity = 84/283 (29.68%), Postives = 130/283 (45.94%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI++ GVC K C + EY+ NGD+ L RR P S H S+ S +S E+ L+ Q + +I + YL + +HRD+ATRNCLVG + K++DF + N N+ IPIRW+P E++ + ++DVW +GV LWE+ S G +PY EV + +IL PENCPLE+Y M++C++
Sbjct: 428 PFTMVAVKMLKEEASPDMQNDFQREAALMAEFDHPNIVKLLGVC--AVGKPMCLLFEYMANGDLNEFL---RRHSPTQSMHT---------------LSCPSISNRSFSSDMEAG-----------------------SLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGQILACPENCPLELYNLMRLCWS 667
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Match: MUSK (muscle associated receptor tyrosine kinase [Source:NCBI gene;Acc:101164489]) HSP 1 Score: 141.354 bits (355), Expect = 4.569e-34 Identity = 84/283 (29.68%), Postives = 130/283 (45.94%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI++ GVC K C + EY+ NGD+ L RR P S H S+ S +S E+ L+ Q + +I + YL + +HRD+ATRNCLVG + K++DF + N N+ IPIRW+P E++ + ++DVW +GV LWE+ S G +PY EV + +IL PENCPLE+Y M++C++
Sbjct: 428 PFTMVAVKMLKEEASPDMQNDFQREAALMAEFDHPNIVKLLGVC--AVGKPMCLLFEYMANGDLNEFL---RRHSPTQSMHT---------------LSCPSISNRSFSSDMEAG-----------------------SLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGQILACPENCPLELYNLMRLCWS 667
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Match: MUSK (muscle associated receptor tyrosine kinase [Source:NCBI gene;Acc:101164489]) HSP 1 Score: 141.354 bits (355), Expect = 4.569e-34 Identity = 84/283 (29.68%), Postives = 130/283 (45.94%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI++ GVC K C + EY+ NGD+ L RR P S H S+ S +S E+ L+ Q + +I + YL + +HRD+ATRNCLVG + K++DF + N N+ IPIRW+P E++ + ++DVW +GV LWE+ S G +PY EV + +IL PENCPLE+Y M++C++
Sbjct: 428 PFTMVAVKMLKEEASPDMQNDFQREAALMAEFDHPNIVKLLGVC--AVGKPMCLLFEYMANGDLNEFL---RRHSPTQSMHT---------------LSCPSISNRSFSSDMEAG-----------------------SLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGQILACPENCPLELYNLMRLCWS 667
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Match: MUSK (muscle associated receptor tyrosine kinase [Source:NCBI gene;Acc:101164489]) HSP 1 Score: 141.739 bits (356), Expect = 4.627e-34 Identity = 84/283 (29.68%), Postives = 130/283 (45.94%), Query Frame = 2
Query: 2066 PFAVI--KYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA 2908
PF ++ K L + + F +E ++++ +HPNI++ GVC K C + EY+ NGD+ L RR P S H S+ S +S E+ L+ Q + +I + YL + +HRD+ATRNCLVG + K++DF + N N+ IPIRW+P E++ + ++DVW +GV LWE+ S G +PY EV + +IL PENCPLE+Y M++C++
Sbjct: 532 PFTMVAVKMLKEEASPDMQNDFQREAALMAEFDHPNIVKLLGVC--AVGKPMCLLFEYMANGDLNEFL---RRHSPTQSMHT---------------LSCPSISNRSFSSDMEAG-----------------------SLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGQILACPENCPLELYNLMRLCWS 771
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Match: SMESG000017131.1 (SMESG000017131.1) HSP 1 Score: 1811.58 bits (4691), Expect = 0.000e+0 Identity = 916/931 (98.39%), Postives = 922/931 (99.03%), Query Frame = 2
Query: 182 VTVAEKYCMYMARYKGKRDVVVDCVDETIIFNSSIHNLIWQRYGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSNKTLIHRCATAVKIIYPLYLILTPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRXXXXXXXXXFINAYVEKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSHSQCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFSAXXXXXXXXXXXXXXXKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKGFNSNSERLQPNKRPRSARXXXXXXXXXXXXXXXXVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKICDKL 2974
+TVAEKYCMYMARYKGKRDVVVDCVDETIIFNSSIHNLIW YGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSN TLIHRCATAVKIIYPLYLI TPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRSQISSQSQQFINAY+EKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSH+QCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFS IGV +FVI IIVI VKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDK FNSNSERLQPNKRPRSARSISESDIKSIDDLILSVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYAL+KSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKIC+KL
Sbjct: 15 LTVAEKYCMYMARYKGKRDVVVDCVDETIIFNSSIHNLIWHHYGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSNITLIHRCATAVKIIYPLYLIWTPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRSQISSQSQQFINAYMEKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSHNQCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFSTIGVALFVIFIIVIVVKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKSFNSNSERLQPNKRPRSARSISESDIKSIDDLILSVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALEKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKICNKL 945
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Match: SMESG000017131.1 (SMESG000017131.1) HSP 1 Score: 1790.39 bits (4636), Expect = 0.000e+0 Identity = 907/921 (98.48%), Postives = 912/921 (99.02%), Query Frame = 2
Query: 212 MARYKGKRDVVVDCVDETIIFNSSIHNLIWQRYGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSNKTLIHRCATAVKIIYPLYLILTPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRXXXXXXXXXFINAYVEKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSHSQCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFSAXXXXXXXXXXXXXXXKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKGFNSNSERLQPNKRPRSARXXXXXXXXXXXXXXXXVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKICDKL 2974
MARYKGKRDVVVDCVDETIIFNSSIHNLIW YGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSN TLIHRCATAVKIIYPLYLI TPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRSQISSQSQQFINAY+EKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSH+QCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFS IGV +FVI IIVI VKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDK FNSNSERLQPNKRPRSARSISESDIKSIDDLILSVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYAL+KSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKIC+KL
Sbjct: 1 MARYKGKRDVVVDCVDETIIFNSSIHNLIWHHYGQVYENKYPYTYLNNGSLHISNLKEDTSYFFCQIWDKSNITLIHRCATAVKIIYPLYLIWTPKNETVNNNTEYLINCHAGGGEYADTIVKYFINDIQVIKNRPFNITNDTKIECRAVSGEDKVSVVAYIIVRRKGTEEDKFLQLECTKIKTKVCDRFLLDDYSRFSNIQLASRKIAADLLERFFSILDSSITLEYEEEKCIDRFKRFICSTFYPRCDNTTNESYVKVLNCRESCESIFYVICRNALHDIRSQISSQSQQFINAYMEKNPFSQSYVSKFISNLTNSILNCDQLPQKIGSSSHNQCDRVNLDISPADKSPSEKKCFNNIGRNYVGQYSISDLNSTKCVNWSLLPQLYVSFHQQNLENQSNYCRNPGGIYQRPVCAINLKKSNSIHIENIRLIVCTNLPLCKTNELKYDPMQGKTNIIMFSTIGVALFVIFIIVIVVKCFAKVRNGIHKKIYSTENIPLNEDEVHLFPNLVYKHSLNGGFECPIYNAAHFEKVQALAVGEYGEIVLVQAVIDNTSSLVLDKSFNSNSERLQPNKRPRSARSISESDIKSIDDLILSVEKTFNEKPCWPFDKSSPSGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALEKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFAPSRQRPCLDIVKNNLMKICNKL 921
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Match: SMESG000041792.1 (SMESG000041792.1) HSP 1 Score: 118.242 bits (295), Expect = 9.145e-27 Identity = 73/293 (24.91%), Postives = 132/293 (45.05%), Query Frame = 2
Query: 2054 SGSCPFAVIKYLNNADNDQKEARFNKETKILSQMNHPNILRFYGVCLHISKKVTCRIVEYLPNGDIKSILTGTRREPPKSSNHENNNKIRNGYQTVYALQKSRSVKTDSHNSSEESKFFKWKNASNQTREIERPQPAENIDLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQK-FSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCF-APSRQRP 2926
+G+ ++K L+ + + + F +E +++S++ H N+L GV I + C I +++ GD+ +L T ++ +V DS ++ ++ L+Y + +I + YL ++ +HRD+A RN L+G NL K+SD ++ +S + +PIRW+ E + F ++DVW +GV LWE+ S G +P+ + EV E + S +IL P+NCP ++Y+ M C+ R RP
Sbjct: 507 TGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGV--SIRQIPWCLIFDFMEKGDLHELLIS---------------------NTTMEVRSISTVPADSMDA------------------------YGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRP 752
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Match: SMESG000004201.1 (SMESG000004201.1) HSP 1 Score: 110.153 bits (274), Expect = 1.229e-25 Identity = 60/171 (35.09%), Postives = 91/171 (53.22%), Query Frame = 2
Query: 2477 LTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLI-----GNPNEYI------PIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMC-FAPSRQRPCLDIVKNNL 2953
L + L+ WG +I D + YL + +IHRD+ATRN L L+D +Q +G I N NE + PIRWL ETL N I++ TDVW FG+ LWE+ ++G+ PY E D+ E+ ++ L PE C +++Y+ M C + + RP + + + L
Sbjct: 51 LCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVL--------LNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTL 213
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Match: SMESG000042606.1 (SMESG000042606.1) HSP 1 Score: 107.457 bits (267), Expect = 2.084e-23 Identity = 58/169 (34.32%), Postives = 82/169 (48.52%), Query Frame = 2
Query: 2474 DLTYKQLVQWGFEICDAIVYLHTKHLIHRDIATRNCLVGMNLEAKLSDFSFVQKFSYGFDLIGNPNEYIPIRWLPKETLENLIFNTDTDVWMFGVYLWELMSFGKEPYCEYDLHEVYEAIVSDKILEIPENCPLEIYEQMKMCFA--PSRQRPCLDIVKNNLMKICDKL 2974
DL L+ +I + YL + IHRD+A RNCLVG + K++DF + + PI+W E L F+T +DVW FGV LWEL ++G PY +L +VY + I+ P CP IY+ MK C+ P RP + N L K+ +
Sbjct: 347 DLPPPVLLYMAIQIAAGMEYLEQHNFIHRDLAARNCLVGQDNIVKVADFGLARCMERDDTYTAHVGAKFPIKWTAPEGLAYNQFSTKSDVWAFGVLLWELATYGMTPYPGIELQDVYVYLEKGNIMNRPAGCPDNIYDIMKQCWQWFP-ESRPSFKDLHNELEKMLSNI 514 The following BLAST results are available for this feature:
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Muscle associated receptor tyrosine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001950 ID=SMED30001950|Name=Muscle associated receptor tyrosine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=3008bpback to top protein sequence of SMED30001950-orf-1 >SMED30001950-orf-1 ID=SMED30001950-orf-1|Name=SMED30001950-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=955bp MDTTIWILENSYVLETWFSQTNSVTVAEKYCMYMARYKGKRDVVVDCVDEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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