IRS-type PTB domain-containing protein

Overview


Name	IRS-type PTB domain-containing protein
Smed ID	SMED30001916
Length (bp)	2116

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of IRS-type PTB domain-containing protein (SMED30001916) t-SNE clustered cells

Violin plots show distribution of expression levels for IRS-type PTB domain-containing protein (SMED30001916) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of IRS-type PTB domain-containing protein (SMED30001916) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for IRS-type PTB domain-containing protein (SMED30001916) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001916

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Category 3 cell	SMED30001916	SMESG000027222.1	dd_Smed_v4_9490_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
Match: DOK3 (docking protein 3 [Source:HGNC Symbol;Acc:HGNC:24583])

HSP 1 Score: 80.1073 bits (196), Expect = 3.479e-15
Identity = 32/90 (35.56%), Postives = 55/90 (61.11%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            M++N +Y S      + V ++ +E + R  +KG  ++ L P+ I+L + K  +AL+ +PY F+R+FG+   +   EAGR+C +GEG F F
Sbjct:  146 MEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAF 235

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Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            M++N +Y S      + V ++ +E + R  +KG  ++ L P+ I+L + K  +AL+ +PY F+R+FG+   +   EAGR+C +GEG F F
Sbjct:  146 MEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAF 235

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
Match: DOK3 (docking protein 3 [Source:HGNC Symbol;Acc:HGNC:24583])

HSP 1 Score: 80.1073 bits (196), Expect = 4.247e-15
Identity = 32/90 (35.56%), Postives = 55/90 (61.11%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            M++N +Y S      + V ++ +E + R  +KG  ++ L P+ I+L + K  +AL+ +PY F+R+FG+   +   EAGR+C +GEG F F
Sbjct:  202 MEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAF 291

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
Match: DOK1 (docking protein 1 [Source:HGNC Symbol;Acc:HGNC:2990])

HSP 1 Score: 68.9366 bits (167), Expect = 8.234e-12
Identity = 29/95 (30.53%), Postives = 51/95 (53.68%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRN----EALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFR 945
            M +N +Y  T   + + V ++ +E + R G+ GSY++++  E + L  +       E L  +PY  +RR+G    +   EAGR+C +G G F F+
Sbjct:    1 MLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQ 95

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
Match: DOK1 (docking protein 1 [Source:HGNC Symbol;Acc:HGNC:2990])

HSP 1 Score: 69.3218 bits (168), Expect = 1.277e-11
Identity = 29/95 (30.53%), Postives = 51/95 (53.68%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRN----EALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFR 945
            M +N +Y  T   + + V ++ +E + R G+ GSY++++  E + L  +       E L  +PY  +RR+G    +   EAGR+C +G G F F+
Sbjct:  140 MLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQ 234

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Fly
Match: Dok (gene:FBgn0029944 transcript:FBtr0071049)

HSP 1 Score: 61.2326 bits (147), Expect = 2.336e-9
Identity = 47/174 (27.01%), Postives = 80/174 (45.98%), Query Frame = 1

Query:  484 IKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKG-SYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELK 1002
            +KR+ T  +  S E++  D I         A  +  +CD        SP       S  I    +DN++Y S S D  + + +  SE S R  I+  +Y++++ P  ++L        +  +PY FIR++G ++     EAGRKC+TGEG F     +  +    +   +K +K
Sbjct:   83 VKRQATLTLSTSSEEELKDWI--------TALQTVAFCD-------TSP-------SGGIGAIEEDNDLYCS-SFDGLFIITLIPSEASIRCCIEPKTYMLQMTPTELQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKSMK 233

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Match: CABZ01072950.1 (pep scaffold:GRCz11:KN150642.1:16216:27684:-1 gene:ENSDARG00000114879.1 transcript:ENSDART00000180226.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CABZ01072950.1)

HSP 1 Score: 88.1965 bits (217), Expect = 6.470e-18
Identity = 35/109 (32.11%), Postives = 64/109 (58.72%), Query Frame = 1

Query:  664 YFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELV 990
            Y  + DNE+Y +  +  F  VC++ +E S+R+ + G Y++  + E + L D++  E +  +PY  +RRFG     + +EAGR+C +GEG F+F+ K   +    I++ +
Sbjct:   87 YLPLADNELYSTWGTGQF-QVCVQSTESSQRLRLSGYYLLSADKETVSLLDLRTGEPIQRWPYRLLRRFGPVKGGIMIEAGRRCPSGEGQFIFQSKQGSQIHRAIEDAI 194

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Match: dok1a (docking protein 1a [Source:ZFIN;Acc:ZDB-GENE-080721-2])

HSP 1 Score: 72.7886 bits (177), Expect = 6.634e-13
Identity = 33/114 (28.95%), Postives = 64/114 (56.14%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACV 1014
            M+DN++Y S    + + V + +S+ S R G+KG Y ++   + + + D+     + E+PY  +RR+G    L  +EAGR+C +G G F F  + + + +  I+  +++ K+  V
Sbjct:  132 MEDNQIYMSREQLSEFKVVVLQSDASVRCGLKGQYWLQTGEDMLLIQDLDTRRTVMEWPYKLLRRYGRDKMLFSIEAGRRCESGPGTFNFETQQSEEILRLIESAIRQQKSLSV 245

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Match: dok1b (docking protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2063])

HSP 1 Score: 71.2478 bits (173), Expect = 2.027e-12
Identity = 35/113 (30.97%), Postives = 59/113 (52.21%), Query Frame = 1

Query:  667 FAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT 1005
              M +N +Y S    N + V ++ +E S R G+ G+Y ++ N + + L D K  + L  +PY  +RR+G    +   EAGR+C +G G F F  K   +    ++E ++E K 
Sbjct:  134 LQMAENLIYYSREEVNEFLVTVQRTEASERCGLSGNYWLRANMDNLILKDPKTKKDLLIWPYKLLRRYGRDRVMFSFEAGRRCESGPGNFTFETKQGNEIFHIVEESIREQKA 246

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Match: dok2 (docking protein 2 [Source:ZFIN;Acc:ZDB-GENE-080721-4])

HSP 1 Score: 69.3218 bits (168), Expect = 6.702e-12
Identity = 37/109 (33.94%), Postives = 57/109 (52.29%), Query Frame = 1

Query:  673 MDDNEVY---ESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELV 990
            M DN +Y   E+T  D  + V +  SE S R  +KG  +++ + + + L D K  E L+ +PY F+RRFG        EAGR+C +GEG F F  K       +++  +
Sbjct:   76 MADNTLYCSRETTMKD--FKVTVRRSEASERCSLKGVVLLRTDTDSLLLKDPKTGEVLYSWPYRFLRRFGRDKATFSFEAGRRCDSGEGSFEFDTKQGNAIFQSVEAAI 182

[Close]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Match: dok2 (docking protein 2 [Source:ZFIN;Acc:ZDB-GENE-080721-4])

HSP 1 Score: 69.707 bits (169), Expect = 6.884e-12
Identity = 37/109 (33.94%), Postives = 57/109 (52.29%), Query Frame = 1

Query:  673 MDDNEVY---ESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELV 990
            M DN +Y   E+T  D  + V +  SE S R  +KG  +++ + + + L D K  E L+ +PY F+RRFG        EAGR+C +GEG F F  K       +++  +
Sbjct:  126 MADNTLYCSRETTMKD--FKVTVRRSEASERCSLKGVVLLRTDTDSLLLKDPKTGEVLYSWPYRFLRRFGRDKATFSFEAGRRCDSGEGSFEFDTKQGNAIFQSVEAAI 232

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Xenopus
Match: fchsd1 (FCH and double SH3 domains 1 [Source:Xenbase;Acc:XB-GENE-6257860])

HSP 1 Score: 68.5514 bits (166), Expect = 1.232e-11
Identity = 34/103 (33.01%), Postives = 56/103 (54.37%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIK 981
            + +NE+Y ST+ +  + V I  +E S R G+ G Y +      + L D +   +L+ +PY ++RRFG    +   EAGR+C++GEG F F     G+    I+
Sbjct:  136 LQENELY-STTRETGFVVRIRPTEASVRCGLNGIYTLSTENSCLSLRDRQTGSSLYNWPYPYLRRFGRDKSMFSFEAGRRCTSGEGSFEFETPLGGQIFQAIE 237

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Xenopus
Match: frs2 (fibroblast growth factor receptor substrate 2 [Source:NCBI gene;Acc:100038035])

HSP 1 Score: 55.8398 bits (133), Expect = 1.962e-7
Identity = 27/88 (30.68%), Postives = 51/88 (57.95%), Query Frame = 1

Query:  769 GSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNPDID 1032
            GS IM+L    + L   KR+    ++PY+ +RR+G  ++L   E+GR+C TG+G F F+   A +    ++E+++    + V+ P ++
Sbjct:   34 GSGIMELTENELILYTRKRDSV--KWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSISVVEEPVVE 119

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Xenopus
Match: dnajc5g (DnaJ heat shock protein family (Hsp40) member C5 gamma [Source:Xenbase;Acc:XB-GENE-5761475])

HSP 1 Score: 54.299 bits (129), Expect = 5.049e-7
Identity = 27/85 (31.76%), Postives = 48/85 (56.47%), Query Frame = 1

Query:  769 GSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNP 1023
            GS +M+L    + L   KR+     +PY+ +RR+G  ++L   E+GR+C TG+G F F+   A +    ++EL++    + V+ P
Sbjct:   32 GSGVMELTQTELVLHTRKRDAV--RWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQELMQRNSISVVEEP 114

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Mouse
Match: Dok3 (docking protein 3 [Source:MGI Symbol;Acc:MGI:1351490])

HSP 1 Score: 72.7886 bits (177), Expect = 6.155e-13
Identity = 29/93 (31.18%), Postives = 54/93 (58.06%), Query Frame = 1

Query:  664 YFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            +  M++N +Y S      + V ++ +E + R  +KG Y++ L  + I+L +  + +A   +PY F+R++G+   +   EAGR+C +GEG F F
Sbjct:  143 FVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAF 235

[Close]

Query:  664 YFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            +  M++N +Y S      + V ++ +E + R  +KG Y++ L  + I+L +  + +A   +PY F+R++G+   +   EAGR+C +GEG F F
Sbjct:  143 FVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAF 235

[Close]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Mouse
Match: Dok2 (docking protein 2 [Source:MGI Symbol;Acc:MGI:1332623])

HSP 1 Score: 69.3218 bits (168), Expect = 6.375e-12
Identity = 37/120 (30.83%), Postives = 63/120 (52.50%), Query Frame = 1

Query:  673 MDDNEVYESTSSD--NFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCD-IKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNP 1023
            M++NE+Y S+++     Y V I  +E S R  ++GSY ++     +EL    +    L+++PY F+RRFG        EAGR+C +GEG F F  +   +    +++++   K A    P
Sbjct:  136 MEENELYSSSTTGLCKEYMVTIRPTEASERCRLRGSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKATFSFEAGRRCLSGEGNFEFETRHGNEIFQALEKVIAVQKNATPSGP 255

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Mouse
Match: Dok1 (docking protein 1 [Source:MGI Symbol;Acc:MGI:893587])

HSP 1 Score: 67.781 bits (164), Expect = 2.403e-11
Identity = 32/115 (27.83%), Postives = 58/115 (50.43%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRN----EALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT 1005
            M +N +Y  T   + + V  +++E S R G++GSYI+++  E + L  +       E L  +PY  +RR+G    +   EAGR+C +G G F F+          ++  +++ K 
Sbjct:  140 MLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKA 254

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BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7L591|DOK3_HUMAN (Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2)

HSP 1 Score: 80.1073 bits (196), Expect = 2.040e-14
Identity = 32/90 (35.56%), Postives = 55/90 (61.11%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            M++N +Y S      + V ++ +E + R  +KG  ++ L P+ I+L + K  +AL+ +PY F+R+FG+   +   EAGR+C +GEG F F
Sbjct:  202 MEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAF 291

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BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Match: sp|B2RYG7|DOK3_RAT (Docking protein 3 OS=Rattus norvegicus OX=10116 GN=Dok3 PE=1 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 6.047e-13
Identity = 30/93 (32.26%), Postives = 55/93 (59.14%), Query Frame = 1

Query:  664 YFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            +  M++N +Y S      + V ++ +E + R  +KG Y++ L  + I+L +  + +A + +PY F+R+FG+   +   EAGR+C +GEG F F
Sbjct:  143 FVPMEENSIYSSWQEVAEFPVVVQRTEATTRCQLKGPYLLVLGQDDIQLRETSKPQACYSWPYRFLRKFGSDKGVFSFEAGRRCDSGEGLFAF 235

[Close]

BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Match: sp|A7MBB8|DOK2_BOVIN (Docking protein 2 OS=Bos taurus OX=9913 GN=DOK2 PE=2 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 1.721e-12
Identity = 38/122 (31.15%), Postives = 63/122 (51.64%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNF---YTVCIEESEDSRRMGIKGSYIMKLNPEGIELCD-IKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNPD 1026
            M++NE+Y ST++      + V +  +E S R  ++GSY +++    +EL    +    L+E+PY F+RRFG        EAGR+C +GEG F F  +   +    ++E +   K A    P 
Sbjct:  133 MEENELYSSTTAGTPQKEFAVTVRPTEVSERCRLRGSYTLRVGESALELWGGPESGTQLYEWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPPGPQ 254

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BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9QZK7|DOK3_MOUSE (Docking protein 3 OS=Mus musculus OX=10090 GN=Dok3 PE=1 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 4.305e-12
Identity = 29/93 (31.18%), Postives = 54/93 (58.06%), Query Frame = 1

Query:  664 YFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            +  M++N +Y S      + V ++ +E + R  +KG Y++ L  + I+L +  + +A   +PY F+R++G+   +   EAGR+C +GEG F F
Sbjct:  143 FVPMEENSIYSSWQEVTEFPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAF 235

[Close]

BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Match: sp|O70469|DOK2_MOUSE (Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2 PE=1 SV=1)

HSP 1 Score: 69.3218 bits (168), Expect = 4.459e-11
Identity = 37/120 (30.83%), Postives = 63/120 (52.50%), Query Frame = 1

Query:  673 MDDNEVYESTSSD--NFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCD-IKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNP 1023
            M++NE+Y S+++     Y V I  +E S R  ++GSY ++     +EL    +    L+++PY F+RRFG        EAGR+C +GEG F F  +   +    +++++   K A    P
Sbjct:  136 MEENELYSSSTTGLCKEYMVTIRPTEASERCRLRGSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKATFSFEAGRRCLSGEGNFEFETRHGNEIFQALEKVIAVQKNATPSGP 255

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BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Match: I1ZIE1 (Uncharacterized protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 8.789e-42
Identity = 91/95 (95.79%), Postives = 93/95 (97.89%), Query Frame = 2

Query: 1445 VQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSFSAQXXXXXXXXXXXXKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 1729
            VQVSIPIT+ + QSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN
Sbjct:    1 VQVSIPITQYEGQSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 95

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BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Match: A0A158QBS0 (IRS-type PTB domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS384 PE=4 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 6.071e-19
Identity = 65/220 (29.55%), Postives = 104/220 (47.27%), Query Frame = 1

Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGI-KGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDA-GKAVTTIKELVKEL 999
            K+L+     E + T W S++  ++ K K    K+ + +    +DS +    T +  DSH+         TL   SN   SN+Y  E  +I                     DNEVYE  S+ +     I++  D  ++ + K    ++L  + +EL D      LH FPY+ IRRFGA   +LR++AGR+CSTG+G+F F    + G+ V  I   +++L
Sbjct:  124 KRLYLAMSSETEATTWMSMIKANLGKRK----KANRNSLTQSRDSLV---GTLRPSDSHD---------TLRGDSNLNPSNRYDLEIDTI---------------------DNEVYEPCSAQDLIPAVIQQRGDWDKLRLSKMDCFLRLTDDRLELLDHNGERVLHWFPYLLIRRFGAVGGVLRVDAGRRCSTGDGHFFFTCSPSNGQPVDAIVSQIRQL 306

HSP 2 Score: 35.4242 bits (80), Expect = 6.071e-19
Identity = 17/41 (41.46%), Postives = 24/41 (58.54%), Query Frame = 3

Query:  237 VLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVL 359
             LCNLSE+K   +  V       FA+KL+P+GI  +K+  L
Sbjct:   88 ALCNLSEYKLCTVVTVEVNELGYFALKLVPAGIFGNKRLYL 128

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BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Match: A0A068YF77 (Docking protein 3 OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000848300 PE=4 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 7.578e-19
Identity = 62/220 (28.18%), Postives = 102/220 (46.36%), Query Frame = 1

Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGI-KGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDA-GKAVTTIKELVKEL 999
            K+L+     E + T W S++  ++ K K    K++K      +DS +    T +  DS +         TL   S+A  +N+Y                     ++     DNEVYE  S+ +     I++  D  ++ + K    ++L  + +EL D      LH FPY+ IRRFGA   +LR++AGR+CSTG+G+F F    + G+ V  I   ++ L
Sbjct:  123 KRLYLAMSGETEATTWMSMIKANLGKRK----KASKNPLTQSRDSLV---GTLRPSDSQD---------TLRGDSSANVNNRY---------------------DLDIDTIDNEVYEPCSAQDLIPAIIQQRGDWEKLRLSKMDCFLRLTDDRLELLDHNGERVLHWFPYLLIRRFGAVGGVLRIDAGRRCSTGDGHFFFMCSPSNGQPVDAIVSQIRHL 305

HSP 2 Score: 41.2022 bits (95), Expect = 7.578e-19
Identity = 18/41 (43.90%), Postives = 27/41 (65.85%), Query Frame = 3

Query:  237 VLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVL 359
             LCNLSE+KS  +  V+  +   FA+KL+P+GI  +K+  L
Sbjct:   87 ALCNLSEYKSCTVVTVSINDVGHFALKLVPAGIFGNKRLYL 127

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BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Match: A0A068W859 (Docking protein 3 OS=Echinococcus granulosus OX=6210 GN=EgrG_000848300 PE=4 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.506e-17
Identity = 58/200 (29.00%), Postives = 92/200 (46.00%), Query Frame = 1

Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGI-KGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            K+L+     E + T W S++  ++ K K    K+ K      +DS +    T +  DS +         TL   S+A  +N+Y                     ++     DNEVYE  S+ +     I++  D  ++ + K    ++L  + +EL D      LH FPY+ IRRFGA   +LR++AGR+CSTG+G F F
Sbjct:  123 KRLYLAMSGETEATTWMSMIKANLGKRK----KAAKNPLTQSRDSLV---GTLRPSDSQD---------TLRGDSSANVNNRY---------------------DLDIDTIDNEVYEPCSAQDLIPAIIQQRGDWEKLRLSKMDCFLRLTDDRLELLDHNGERVLHWFPYLLIRRFGAVGGVLRIDAGRRCSTGDGRFFF 285

HSP 2 Score: 40.4318 bits (93), Expect = 1.506e-17
Identity = 22/65 (33.85%), Postives = 36/65 (55.38%), Query Frame = 3

Query:  165 SRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVL 359
            S  +  S+V+ + R+          LCNLSE+KS  +  V+  +   FA+KL+P+GI  +K+  L
Sbjct:   70 SNPTQLSSVTPVTRA-------FTALCNLSEYKSCTVVTVSINDVGYFALKLVPAGIFGNKRLYL 127

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BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Match: A0A095AGQ6 (IRS-type PTB domain-containing protein (Fragment) OS=Schistosoma haematobium OX=6185 GN=MS3_01246 PE=4 SV=1)

HSP 1 Score: 90.1225 bits (222), Expect = 1.062e-14
Identity = 44/117 (37.61%), Postives = 71/117 (60.68%), Query Frame = 1

Query:  670 AMDDNEVYESTSSDNFYTVCIEESEDSRRMGI-KGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRF-----KDAGKAVTTIKELVKELK 1002
             + DNEVYE+ SS++     +EE+ D  ++ + +    ++L  + +E+ D   ++ +H FPY+ IRRFGA N +LR++AGR+CSTG+G F FR      +     VT I++L  E K
Sbjct:  163 GLMDNEVYEAYSSEDKIPALLEEAGDWMKLHLCQPDCYLRLTTDRLEVLDFYSHKPVHWFPYLLIRRFGASNGVLRVDAGRRCSTGDGKFFFRCSPPNGQPVDALVTQIRQLALEAK 279

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000033117.1 (docking protein 3 [Source:NCBI gene;Acc:103036151])

HSP 1 Score: 79.337 bits (194), Expect = 6.231e-15
Identity = 37/107 (34.58%), Postives = 64/107 (59.81%), Query Frame = 1

Query:  670 AMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELV 990
            +M +N++Y ST S   + V +++S+ S R  + GSY++    E + L D++  + +  +PY F+RRFG   + + +EAGR+C TGEG+F F  K   +    I+E +
Sbjct:  135 SMSENDLY-STWSPGKFQVTVQKSDASVRCCMSGSYLLSPEKEALCLLDLRTGKTVFYWPYRFLRRFGQIKEGVTIEAGRRCQTGEGHFAFLSKQGTQIYRAIEEAI 240

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Match: dok1a (docking protein 2-like [Source:NCBI gene;Acc:103039100])

HSP 1 Score: 78.5666 bits (192), Expect = 6.759e-15
Identity = 33/114 (28.95%), Postives = 68/114 (59.65%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACV 1014
            M++N++Y S      + V +++SE + R G++G+Y ++   E + + D +  + + E+PY  +RR+G    +  +EAGR+C +G G FVF  K + + +  +++ +++ KT  V
Sbjct:  132 MEENQIYASREEVFDFWVTLQQSEAAVRCGLQGAYWLQTGEESLIIQDTESRQRVIEWPYKLLRRYGGDKTVFSIEAGRRCESGPGTFVFETKQSEEILRRVEQAIQQQKTLSV 245

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Match: dok2 (docking protein 2 [Source:NCBI gene;Acc:103024435])

HSP 1 Score: 68.1662 bits (165), Expect = 1.447e-11
Identity = 39/118 (33.05%), Postives = 62/118 (52.54%), Query Frame = 1

Query:  670 AMDDNEVY-----ESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTA 1008
            AM DN +Y      STS+   + V +  ++ + R G++G Y+++ + + + L + K  E L  +PY ++RRFG        EAGR+C +GEG F F  K  G A+    E    L+ A
Sbjct:  139 AMSDNSLYGGRETASTSTMKDFKVSMRRTDAAERCGLRGQYLLRTDFDSLLLKEPKIGEVLFTWPYRYLRRFGRDKTTFSFEAGRRCDSGEGNFEFDTKQ-GNAIFQYVETAISLQKA 255

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Match: dok1b (docking protein 1 [Source:NCBI gene;Acc:103027364])

HSP 1 Score: 67.3958 bits (163), Expect = 3.367e-11
Identity = 36/115 (31.30%), Postives = 61/115 (53.04%), Query Frame = 1

Query:  667 FAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCD--IKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT 1005
              M +N +Y S    N + V ++++E S R G+ G+Y +K + E + L D   KRN+ +  +PY  +RR+G    +   EAGR+C +G G F F  K   +    ++  ++E K 
Sbjct:  134 LQMAENLIYYSREEVNEFWVSVQKTEASERCGLLGNYWLKADGENLILKDPKTKRNQLV--WPYKLLRRYGRDRVMFSFEAGRRCESGPGNFTFETKQGNEIFQIVENAIREQKA 246

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000036887.1 (docking protein 3-like [Source:NCBI gene;Acc:103043435])

HSP 1 Score: 63.1586 bits (152), Expect = 6.195e-10
Identity = 33/90 (36.67%), Postives = 48/90 (53.33%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVF 942
            M +N +YE  +S   + V    +E + R  + G YI+  + + I L D K  + L  +PY FIR+FG        EAGR+C +GEG F F
Sbjct:  146 MKENSLYEPAASLRDFLVIAMGTEAALRCKLYGEYILTPHDDRILLKDHKTKQVLFSWPYCFIRKFGQDRLSFSFEAGRRCESGEGNFEF 235

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010596.1 (pep scaffold:Pmarinus_7.0:GL476339:448786:450942:-1 gene:ENSPMAG00000009596.1 transcript:ENSPMAT00000010596.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 67.0106 bits (162), Expect = 4.926e-12
Identity = 33/97 (34.02%), Postives = 53/97 (54.64%), Query Frame = 1

Query:  712 NFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELK 1002
            N + V I ++E S R G+ GSY +K + E + L D     A++ +PY  +RRFG        EAGR+C++G G F+F  K+       I++ + + K
Sbjct:    1 NEFWVSIHKTEASERCGLVGSYKLKGDQEDLTLKDPASGNAIYVWPYKLLRRFGRDKTSFTFEAGRRCNSGPGTFMFDTKNGNDIFNIIEKSINQTK 97

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000035735.1 (docking protein 3 [Source:NCBI gene;Acc:110014047])

HSP 1 Score: 77.0258 bits (188), Expect = 2.560e-14
Identity = 32/115 (27.83%), Postives = 68/115 (59.13%), Query Frame = 1

Query:  652 SDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKE 996
            S  ++  +++N++Y S      + V ++++E + R G++GSY +++    + L + ++ + + E+PY  +RR+G+   +L +EAGR+C +G G F F    A K  + I+  +K+
Sbjct:  139 SGNVHAHLEENQIYASAGEARQFWVAVQKTEAATRCGLEGSYWLEVGGASLLLREAQKKKLVGEWPYEQLRRYGSHQSVLTIEAGRRCGSGPGIFNFESSQAEKIFSLIQSSIKQ 253

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000043898.1 (docking protein 3 [Source:NCBI gene;Acc:105354926])

HSP 1 Score: 68.5514 bits (166), Expect = 9.600e-12
Identity = 34/102 (33.33%), Postives = 56/102 (54.90%), Query Frame = 1

Query:  667 FAMDDNEVYESTSSDNF-----YTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDA 957
             AM+DNE+Y + + D       + V I+ +  S+R  + G Y+M    E + L  +  ++A+  +PY  +RRFG       +EAGR+C +GEG F+F  + A
Sbjct:  137 LAMEDNELYSTWNKDPTLPPKQFKVKIKSTIASKRCKLAGEYLMSSETEALVLFSLDASDAIFRWPYRLLRRFGKVEGGFSIEAGRRCESGEGLFIFLTRHA 238

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Match: dok1b (docking protein 1 [Source:NCBI gene;Acc:101173260])

HSP 1 Score: 66.2402 bits (160), Expect = 6.593e-11
Identity = 34/113 (30.09%), Postives = 55/113 (48.67%), Query Frame = 1

Query:  667 FAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT 1005
              M DN +Y S    N + V ++ SE S R G+ G+Y +K   + + L + K    +  +PY  +RR+G    +   EAGR+C +G G F F  K      T + + ++  K 
Sbjct:  146 LQMADNLIYYSREEVNEFWVTVQRSEASERCGLSGNYWLKAESDVLILKEPKTKRRVLVWPYKLLRRYGRDRVMFSFEAGRRCESGPGNFTFDTKQGNDIFTVVDQAIQSQKA 258

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Match: dok1b (docking protein 1 [Source:NCBI gene;Acc:101173260])

HSP 1 Score: 66.2402 bits (160), Expect = 7.065e-11
Identity = 34/113 (30.09%), Postives = 55/113 (48.67%), Query Frame = 1

Query:  667 FAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT 1005
              M DN +Y S    N + V ++ SE S R G+ G+Y +K   + + L + K    +  +PY  +RR+G    +   EAGR+C +G G F F  K      T + + ++  K 
Sbjct:  146 LQMADNLIYYSREEVNEFWVTVQRSEASERCGLSGNYWLKAESDVLILKEPKTKRRVLVWPYKLLRRYGRDRVMFSFEAGRRCESGPGNFTFDTKQGNDIFTVVDQAIQSQKA 258

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BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Match: dok2 (docking protein 2 [Source:NCBI gene;Acc:101174926])

HSP 1 Score: 62.7734 bits (151), Expect = 7.648e-10
Identity = 29/113 (25.66%), Postives = 60/113 (53.10%), Query Frame = 1

Query:  670 AMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTA 1008
             M+DN +Y    + + + V + +++ S R  +KG  +++ + + + L D +  + ++ +PY ++RRFG        EAGR+C +GEG F F  K+       ++  + + K +
Sbjct:  146 GMEDNSLYSGRETVHDFRVSVRKTDASDRCRLKGDGVLRADMDALHLLD-RAGDVVYSWPYRYLRRFGRDKCTFSFEAGRRCDSGEGNFEFDTKEGNSLFQAVEAAINQQKIS 257

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BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST
Match: SMESG000027222.1 (SMESG000027222.1)

HSP 1 Score: 532.332 bits (1370), Expect = 0.000e+0
Identity = 256/259 (98.84%), Postives = 256/259 (98.84%), Query Frame = 1

Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK 1122
            KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKREN KQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDN YTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT CVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK
Sbjct:  113 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENNKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNVYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTTCVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK 371

HSP 2 Score: 337.035 bits (863), Expect = 0.000e+0
Identity = 200/205 (97.56%), Postives = 203/205 (99.02%), Query Frame = 2

Query: 1115 KKKSPVQSSVSLLTSPVITITKPAISQTVKTDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSIXXXXXXXXXXXXXXXXXXRLPVMNNAFNRNQYAASFSYRRPVQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSFSAQXXXXXXXXXXXXKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 1729
            +KKSPVQS+VSL TSPVITI+KPAISQTV TDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSISLVNNSTSNLVSSSSTSSRLPVMNNAFNRNQYAASFSYRRPVQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN
Sbjct:  369 QKKSPVQSNVSLPTSPVITISKPAISQTVNTDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSISLVNNSTSNLVSSSSTSSRLPVMNNAFNRNQYAASFSYRRPVQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 573

HSP 3 Score: 173.326 bits (438), Expect = 4.779e-46
Identity = 122/149 (81.88%), Postives = 125/149 (83.89%), Query Frame = 3

Query:    9 MKSSRVXXXXXXXXXXXXDWIYCDAQILKQNQISMLKLXXXXXXXXXXXXXQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVLHSRIRRRPDKVVQLAGRTHL*KQRQRNQIHKT 455
            MKSSRVYIKANYIKKAKIDWIYCDAQILKQNQISMLKLSSISNSNDDKDDNQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKK            K   L G  H+ K +  N+I  T
Sbjct:    1 MKSSRVYIKANYIKKAKIDWIYCDAQILKQNQISMLKLSSISNSNDDKDDNQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKLFFIPEYEEDLTKWCSLLGE-HIYKNKD-NEIKST 147

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Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK 1122
            KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKREN KQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDN YTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKT CVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK
Sbjct:  113 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENNKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNVYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTTCVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKK 371

HSP 2 Score: 317.39 bits (812), Expect = 0.000e+0
Identity = 193/205 (94.15%), Postives = 196/205 (95.61%), Query Frame = 2

Query: 1115 KKKSPVQSSVSLLTSPVITITKPAISQTVKTDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSIXXXXXXXXXXXXXXXXXXRLPVMNNAFNRNQYAASFSYRRPVQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSFSAQXXXXXXXXXXXXKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 1729
            +KKSPVQS+VSL TSPVITI+KPAISQTV TDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSISLVNNSTSNLVSSSSTSSRLPVMNNAFNRNQYAASFSYRRPVQ       DDSQSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN
Sbjct:  369 QKKSPVQSNVSLPTSPVITISKPAISQTVNTDHQHLTYSQPQICQIKKPLHPLYNSVNSVPNGRSSPSISLVNNSTSNLVSSSSTSSRLPVMNNAFNRNQYAASFSYRRPVQ-------DDSQSRSVIYDNIPSYEQRAGQSGSFSAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELESMLMDLGITTN 566

HSP 3 Score: 172.94 bits (437), Expect = 4.742e-46
Identity = 122/149 (81.88%), Postives = 125/149 (83.89%), Query Frame = 3

Query:    9 MKSSRVXXXXXXXXXXXXDWIYCDAQILKQNQISMLKLXXXXXXXXXXXXXQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVLHSRIRRRPDKVVQLAGRTHL*KQRQRNQIHKT 455
            MKSSRVYIKANYIKKAKIDWIYCDAQILKQNQISMLKLSSISNSNDDKDDNQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKK            K   L G  H+ K +  N+I  T
Sbjct:    1 MKSSRVYIKANYIKKAKIDWIYCDAQILKQNQISMLKLSSISNSNDDKDDNQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKLFFIPEYEEDLTKWCSLLGE-HIYKNKD-NEIKST 147

[Close]

BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST
Match: SMESG000055009.1 (SMESG000055009.1)

HSP 1 Score: 137.117 bits (344), Expect = 2.271e-47
Identity = 76/221 (34.39%), Postives = 118/221 (53.39%), Query Frame = 1

Query:  346 KKLFFIPEYEEDLTKWCSLLGEHIYKNKDNEIKSTKLTDNVDKDSTIKRENTKQIKDSHEKKESDDIMSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTA 1008
            KKL+ +P+ E+ LT+WC L+   I K             N +  S    EN   +  S   + S   M+ L+ +                    P +Y      ++Y ++DDN+ YESTS D F+ V +E + DS ++ ++G+YIMKL  + +EL D+   E +H FP+  IRRFGAKNDL +LEAGR C+TG G+F+F+ +DA     T+K   +++K +
Sbjct:  115 KKLYLLPDLEDSLTEWCGLITGFISKT------------NTNSPSDYNAENKSAMSISSSLRSSR--MTQLSPQ--------------------PSNY-----QDLYISLDDNDAYESTSHDEFHLVTVEMTTDSVKLNMRGNYIMKLGNDILELMDVNTRELIHRFPFASIRRFGAKNDLFKLEAGRHCTTGMGHFIFKVRDAIYIAETLKNSTRQIKMS 296

HSP 2 Score: 72.4034 bits (176), Expect = 2.271e-47
Identity = 57/120 (47.50%), Postives = 74/120 (61.67%), Query Frame = 3

Query:    9 MKSSRVXXXXXXXXXXXXDWIYCDAQILKQNQISMLKLXXX---XXXXXXXXXXQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTEKFAIKLIPSGILNSKKTVL 359
            MKS++ +IK+NYIK  K DWI C  ++L    I+ L L S     N  D   ++ S  S F+ +S IY+SK++    L  LCNLS+FKS EIK V F N  KFAIKL+P+G L SKK  L
Sbjct:    1 MKSAKFFIKSNYIKNTKNDWILCYGKLLYHQNITFLHLKSENFERNPGDSASESDSTYSGFATLSQIYQSKISNQ-RLNALCNLSQFKSCEIKSVRFENVFKFAIKLVPAGFLRSKKLYL 119

[Close]

BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST
Match: SMESG000023429.1 (SMESG000023429.1)

HSP 1 Score: 58.151 bits (139), Expect = 8.179e-9
Identity = 38/115 (33.04%), Postives = 60/115 (52.17%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVK 1017
            M +N+VYE +     +   + E+  S+ +GIKG YI+ +   G+EL D      +  +    IRRFG K+++   E G+    G G   F+  + GK +  IKEL+ E K  C+K
Sbjct:  156 MIENDVYEGSLMPGEFLATVIETAKSKEIGIKGRYILVVTDGGLELKDEYTERIVKIWEIKIIRRFGEKDNVFSFELGKFSEDGPGALCFQV-EKGKQL--IKELI-ETKENCLK 266

[Close]

BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST
Match: SMESG000023429.1 (SMESG000023429.1)

HSP 1 Score: 58.151 bits (139), Expect = 1.117e-8
Identity = 38/115 (33.04%), Postives = 60/115 (52.17%), Query Frame = 1

Query:  673 MDDNEVYESTSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEFPYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKELKTACVK 1017
            M +N+VYE +     +   + E+  S+ +GIKG YI+ +   G+EL D      +  +    IRRFG K+++   E G+    G G   F+  + GK +  IKEL+ E K  C+K
Sbjct:  156 MIENDVYEGSLMPGEFLATVIETAKSKEIGIKGRYILVVTDGGLELKDEYTERIVKIWEIKIIRRFGEKDNVFSFELGKFSEDGPGALCFQV-EKGKQL--IKELI-ETKENCLK 266

The following BLAST results are available for this feature:

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Celegans
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Fly
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Xenopus
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Mouse
BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Sea Lamprey
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Yeast
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Nematostella
BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DOK3	3.479e-15	35.56	docking protein 3 [Source:HGNC Symbol;Acc:HGNC:245...	[more]
DOK3	3.479e-15	35.56	docking protein 3 [Source:HGNC Symbol;Acc:HGNC:245...	[more]
DOK3	4.247e-15	35.56	docking protein 3 [Source:HGNC Symbol;Acc:HGNC:245...	[more]
DOK1	8.234e-12	30.53	docking protein 1 [Source:HGNC Symbol;Acc:HGNC:299...	[more]
DOK1	1.277e-11	30.53	docking protein 1 [Source:HGNC Symbol;Acc:HGNC:299...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Dok	2.336e-9	27.01	gene:FBgn0029944 transcript:FBtr0071049	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CABZ01072950.1	6.470e-18	32.11	pep scaffold:GRCz11:KN150642.1:16216:27684:-1 gene...	[more]
dok1a	6.634e-13	28.95	docking protein 1a [Source:ZFIN;Acc:ZDB-GENE-08072...	[more]
dok1b	2.027e-12	30.97	docking protein 1b [Source:ZFIN;Acc:ZDB-GENE-04042...	[more]
dok2	6.702e-12	33.94	docking protein 2 [Source:ZFIN;Acc:ZDB-GENE-080721...	[more]
dok2	6.884e-12	33.94	docking protein 2 [Source:ZFIN;Acc:ZDB-GENE-080721...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
fchsd1	1.232e-11	33.01	FCH and double SH3 domains 1 [Source:Xenbase;Acc:X...	[more]
frs2	1.962e-7	30.68	fibroblast growth factor receptor substrate 2 [Sou...	[more]
dnajc5g	5.049e-7	31.76	DnaJ heat shock protein family (Hsp40) member C5 g...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Dok3	6.155e-13	31.18	docking protein 3 [Source:MGI Symbol;Acc:MGI:13514...	[more]
Dok3	6.155e-13	31.18	docking protein 3 [Source:MGI Symbol;Acc:MGI:13514...	[more]
Dok2	6.375e-12	30.83	docking protein 2 [Source:MGI Symbol;Acc:MGI:13326...	[more]
Dok1	2.403e-11	27.83	docking protein 1 [Source:MGI Symbol;Acc:MGI:89358...	[more]

BLAST of IRS-type PTB domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q7L591\|DOK3_HUMAN	2.040e-14	35.56	Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 ...	[more]
sp\|B2RYG7\|DOK3_RAT	6.047e-13	32.26	Docking protein 3 OS=Rattus norvegicus OX=10116 GN...	[more]
sp\|A7MBB8\|DOK2_BOVIN	1.721e-12	31.15	Docking protein 2 OS=Bos taurus OX=9913 GN=DOK2 PE...	[more]
sp\|Q9QZK7\|DOK3_MOUSE	4.305e-12	31.18	Docking protein 3 OS=Mus musculus OX=10090 GN=Dok3...	[more]
sp\|O70469\|DOK2_MOUSE	4.459e-11	30.83	Docking protein 2 OS=Mus musculus OX=10090 GN=Dok2...	[more]

BLAST of IRS-type PTB domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I1ZIE1	8.789e-42	95.79	Uncharacterized protein (Fragment) OS=Schmidtea me...	[more]
A0A158QBS0	6.071e-19	29.55	IRS-type PTB domain-containing protein OS=Hymenole...	[more]
A0A068YF77	7.578e-19	28.18	Docking protein 3 OS=Echinococcus multilocularis O...	[more]
A0A068W859	1.506e-17	29.00	Docking protein 3 OS=Echinococcus granulosus OX=62...	[more]
A0A095AGQ6	1.062e-14	37.61	IRS-type PTB domain-containing protein (Fragment) ...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000033117.1	6.231e-15	34.58	docking protein 3 [Source:NCBI gene;Acc:103036151]	[more]
dok1a	6.759e-15	28.95	docking protein 2-like [Source:NCBI gene;Acc:10303...	[more]
dok2	1.447e-11	33.05	docking protein 2 [Source:NCBI gene;Acc:103024435]	[more]
dok1b	3.367e-11	31.30	docking protein 1 [Source:NCBI gene;Acc:103027364]	[more]
ENSAMXT00000036887.1	6.195e-10	36.67	docking protein 3-like [Source:NCBI gene;Acc:10304...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000010596.1	4.926e-12	34.02	pep scaffold:Pmarinus_7.0:GL476339:448786:450942:-...	[more]

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of IRS-type PTB domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000035735.1	2.560e-14	27.83	docking protein 3 [Source:NCBI gene;Acc:110014047]	[more]
ENSORLT00000043898.1	9.600e-12	33.33	docking protein 3 [Source:NCBI gene;Acc:105354926]	[more]
dok1b	6.593e-11	30.09	docking protein 1 [Source:NCBI gene;Acc:101173260]	[more]
dok1b	7.065e-11	30.09	docking protein 1 [Source:NCBI gene;Acc:101173260]	[more]
dok2	7.648e-10	25.66	docking protein 2 [Source:NCBI gene;Acc:101174926]	[more]

BLAST of IRS-type PTB domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000027222.1	4.779e-46	98.84	SMESG000027222.1	[more]
SMESG000027222.1	4.742e-46	98.84	SMESG000027222.1	[more]
SMESG000055009.1	2.271e-47	34.39	SMESG000055009.1	[more]
SMESG000023429.1	8.179e-9	33.04	SMESG000023429.1	[more]
SMESG000023429.1	1.117e-8	33.04	SMESG000023429.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence
protein sequence

transcript sequence

>SMED30001916 ID=SMED30001916|Name=IRS-type PTB domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2116bp
TTAAGAAAATGAAATCTTCTAGAGTTTATATAAAAGCTAATTATATAAAA
AAAGCCAAAATCGATTGGATATATTGCGATGCCCAAATTCTGAAACAGAA
TCAAATCTCTATGCTAAAATTATCATCAATCTCCAATTCAAATGATGATA
AAGATGACAACCAAAGCCGGATTTCTAACTTTTCTAATGTATCGACAATT
TACCGATCGAAATTGACTCAATCGATAGGATTGAAAGTCTTATGTAATCT
CTCAGAATTCAAGTCAAGTGAAATCAAACCGGTAAACTTTTACAACACAG
AAAAATTTGCAATCAAACTCATTCCATCGGGAATTTTGAATTCGAAAAAA
ACTGTTCTTCATTCCCGAATACGAAGAAGACCTGACAAAGTGGTGCAGCT
TGCTGGGAGAACACATTTATAAAAACAAAGACAACGAAATCAAATCCACA
AAACTGACCGATAATGTGGATAAAGATTCGACAATCAAACGAGAAAACAC
TAAACAAATCAAAGATTCACATGAGAAGAAGGAATCTGACGATATCATGT
CGACATTGACGAAAAAATCAAACGCGACAGATTCCAATAAATACTGTGAC
GAAAATTCGAGCATCATTCCGAATTCTCCACAATCGTATCTCAGTTACAA
ATCAGATGAAATCTATTTCGCTATGGACGACAATGAGGTCTACGAGTCAA
CAAGTTCCGACAATTTCTACACGGTTTGCATTGAGGAATCCGAGGACTCA
AGAAGGATGGGAATCAAGGGTAGCTACATTATGAAATTGAATCCAGAAGG
CATTGAATTGTGTGACATCAAACGCAACGAAGCTCTCCATGAATTTCCAT
ATATTTTTATTCGCCGATTTGGAGCTAAGAATGATCTTCTTCGATTGGAA
GCTGGGAGAAAGTGTTCGACGGGAGAAGGATATTTCGTTTTTCGATTCAA
AGACGCCGGAAAAGCCGTGACGACAATTAAGGAGTTGGTGAAAGAATTGA
AAACGGCATGTGTTAAAAATCCCGATATCGATCATGAAGATTCGAGAAGT
GCTAGAAATTCAATGTCAATCTCTATGAATTCGTCCACATTTGAATGCAA
TGTTGACACGAATCAAAAAAAAATCTCCGGTCCAGAGTAGTGTCAGTCTT
CTGACCAGTCCAGTTATAACTATTACCAAGCCGGCTATTTCACAAACGGT
TAAAACTGATCATCAACATCTGACTTATTCTCAACCTCAAATTTGTCAAA
TTAAAAAACCTTTGCACCCGCTTTACAACTCAGTAAATAGCGTACCCAAT
GGTAGAAGTTCTCCATCAATTTCTCTTGTTAATAATTCGACTTCAAATCT
AGTTTCGTCGTCTTCAACTTCTAGTCGATTACCCGTAATGAATAATGCCT
TCAATCGCAACCAATACGCCGCATCGTTCTCGTACAGGCGTCCAGTACAA
GTGAGTATTCCAATAACAAAGGATGATAGTCAATCCCGATCTGTCATATA
TGATAATATACCATCGTATGAGCAGCGAGCTGGCCAGTCAGGTTCGTTTT
CAGCCCAAAACAGTCCAATAATTCCAAACTTGTCGTCCAATTCAAAGTTT
ACCTCTTCATACAGTCTGAACCGGCCCCTGGCAAACACTGCAAGTGGACA
GTATGATAATGTCCCCAACAATCAGCGCTGTATCAGAGAGCTCGAGTCTA
TGCTGATGGATTTAGGGATCACAACAAATTAATTATTCTTCGTTTTATGC
TTATACCGACGGAATGATTTCCTATTAATCGTATAGTTTCATAGTTTTAC
CCATCGATTCCATTATTATTCTCTACAATGCACAAATTGACAGTTCTAAT
TTGTTTATAATAACCGTTACGTCATACTAGTAATTACCGTTTCCACTAAT
TGGCAACAAGTTTGCTTCTGATCCCCACTGTTATTGCGGTTGCTATTTGC
CCAAAGAATTACAGATATAGGCGATAATTGTACATGGGAAATACGACATA
TTTTGCCAACTTTATTTTCTAGTGTTTCATGATGTCAGTTTGCTTTTATT
AACTGTTGTTATTGTTGTTGTTGTGCACTTATTTTTGCTAAATATATTAT
TGAAATTTCAAAAAAA

protein sequence of SMED30001916-orf-1

>SMED30001916-orf-1 ID=SMED30001916-orf-1|Name=SMED30001916-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=140bp
KKMKSSRVYIKANYIKKAKIDWIYCDAQILKQNQISMLKLSSISNSNDDK
DDNQSRISNFSNVSTIYRSKLTQSIGLKVLCNLSEFKSSEIKPVNFYNTE
KFAIKLIPSGILNSKKTVLHSRIRRRPDKVVQLAGRTHL*

protein sequence of SMED30001916-orf-2

>SMED30001916-orf-2 ID=SMED30001916-orf-2|Name=SMED30001916-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=211bp
MLTRIKKKSPVQSSVSLLTSPVITITKPAISQTVKTDHQHLTYSQPQICQ
IKKPLHPLYNSVNSVPNGRSSPSISLVNNSTSNLVSSSSTSSRLPVMNNA
FNRNQYAASFSYRRPVQVSIPITKDDSQSRSVIYDNIPSYEQRAGQSGSF
SAQNSPIIPNLSSNSKFTSSYSLNRPLANTASGQYDNVPNNQRCIRELES
MLMDLGITTN*

protein sequence of SMED30001916-orf-3

>SMED30001916-orf-3 ID=SMED30001916-orf-3|Name=SMED30001916-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=198bp
MSTLTKKSNATDSNKYCDENSSIIPNSPQSYLSYKSDEIYFAMDDNEVYE
STSSDNFYTVCIEESEDSRRMGIKGSYIMKLNPEGIELCDIKRNEALHEF
PYIFIRRFGAKNDLLRLEAGRKCSTGEGYFVFRFKDAGKAVTTIKELVKE
LKTACVKNPDIDHEDSRSARNSMSISMNSSTFECNVDTNQKKISGPE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000026	gut
PLANA:0000035	Category 3 cell
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR002404	IRS_PTB
IPR011993	PH-like_dom_sf
IPR011528	NERD

Vocabulary: **molecular function**
Term	Definition
GO:0005158	insulin receptor binding

Main menu

IRS-type PTB domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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