PH domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001904 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 16
Homology
BLAST of PH domain-containing protein vs. Ensembl Human
Match: FERMT1 (fermitin family member 1 [Source:HGNC Symbol;Acc:HGNC:15889]) HSP 1 Score: 206.068 bits (523), Expect = 4.513e-56 Identity = 173/693 (24.96%), Postives = 319/693 (46.03%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+RV + V L+ +I++ DWS+F W + WLL + ++ +Q +K+ F + +L ++LP+L++ +L + FS VF+ ICK IR EELSL LK S +++ ++ + + N T + + G + PIY P N S + F D L E + S S+ SP EAL D+ ++ D+A W+ S +LMEQ + + +LLR +KY++++ N KYD +RINQ++ Q+ W+++ E DC+ +E + A + +HI+KLS + + A S D EI++ L L L G + ED + ++A N++L + + + +K++ + + I K + P+ +G E+ +V + +K I +I + + +R ++ ++ +W A L SK S+++ E + + + MK+ ++ + + +D +N + K KSK++ ++L ++ + + +EAK+ +I+ W +L G Y V + + I+G+ Y+RLI D TG+ + W NWE ++ F + + S +C+I HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 31 LRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSL----LKP--SGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSSVSPGLYSKTMTPIY------------DPINGTPASSTMTWFSDSPLTEQNCSI---LAFSQPPQSP-----EALA--DMYQPRSLVDKAKLNAGWLDSSRSLMEQGIQEDEQLLLR--FKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVD---EIEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVAGRKFGIKLLIP--------------VADGMNEMYLRCDHENQYAQWMAACMLASKGKTMAD-SSYQPEVLNILSFLRMKNRNSASQVASSLENMD-MNPECFVSPRCAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTG 674
BLAST of PH domain-containing protein vs. Ensembl Human
Match: FERMT2 (fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]) HSP 1 Score: 205.297 bits (521), Expect = 9.515e-56 Identity = 183/715 (25.59%), Postives = 335/715 (46.85%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L T G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQ + + T+ + ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE-ILAKMFKPQALL------DKAKINQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPEQITTD-----ITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 676
BLAST of PH domain-containing protein vs. Ensembl Human
Match: FERMT2 (fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]) HSP 1 Score: 205.297 bits (521), Expect = 9.515e-56 Identity = 183/715 (25.59%), Postives = 335/715 (46.85%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L T G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQ + + T+ + ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE-ILAKMFKPQALL------DKAKINQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPEQITTD-----ITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 676
BLAST of PH domain-containing protein vs. Ensembl Human
Match: FERMT2 (fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]) HSP 1 Score: 198.364 bits (503), Expect = 2.532e-53 Identity = 183/722 (25.35%), Postives = 335/722 (46.40%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L T G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQ + + T+ + ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE-ILAKMFKPQALL------DKAKINQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPEC-----LVSPRYLKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 683
BLAST of PH domain-containing protein vs. Ensembl Human
Match: FERMT2 (fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]) HSP 1 Score: 198.364 bits (503), Expect = 2.532e-53 Identity = 183/722 (25.35%), Postives = 335/722 (46.40%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L T G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQ + + T+ + ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE-ILAKMFKPQALL------DKAKINQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPEC-----LVSPRYLKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 683
BLAST of PH domain-containing protein vs. Ensembl Celegans
Match: unc-112 (pep chromosome:WBcel235:V:14691854:14697107:-1 gene:WBGene00006836.1 transcript:C47E8.7.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-112) HSP 1 Score: 176.792 bits (447), Expect = 3.542e-46 Identity = 175/741 (23.62%), Postives = 334/741 (45.07%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQW----KELKKLDS-----NTPVPXXXXXXXXXXXXXXXXXXXXXXXXTL-------TSGLNTTGH----RKRFTKPIY--LTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKT--YKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINII---KTTNVSSK----IPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNL--------KMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+ I + +LN +I V + + +L+++ ++ DWS+ W P ++ WL + + Q + +++ F IQLPD+Q+ +DFS F+ + +C+ GIR+ EELSL+ ++L++ S N P+ R + + S L + L+ +GH + T P + L R PSP + I +S +E E F+++ L +SP+ + S +D +++ Y ++A W+ S +LMEQ + + ++ LR+K+ N++ N KYD +RINQ++ Q+ WS++ E D + +E L A L L + E N ++D +LD L +L + N D + E+A ++ +K P+ + + A S + + +++V+S +KG E+ +V + +K I ++ T++ ++ ++ ++ +W A RL S+ S+++ E + + N+++M+S N + K + N+ + I S + + +SK+ I Q+V + L+ EAK+ YI+ W L G HY V + +++ + +RL +++ G + W NWE+ + + F + I FK S +C++ HE++GGY+F+ MR+ E +L+E +F LTG
Sbjct: 17 LPILVTDLNIQRSISVLGNLNVGGLMLELVSECDVERDWSDHALWWPEKRRWLQHTRSTLDQNGITAETQLEFTPMHKEARIQLPDMQMIDARVDFSVNSFKATKKLCRDLGIRYSEELSLKRYIPPEDLRRGTSDADNMNGPLSMRPGEESVGPMTLRKAAPIFASQSNLDMRRRGQSPALSQSGHIFNAHEMGTLPRHGTLPRGV-----SPSPGAYNDTMRRTPIMPSISFSEG--LENEQFDDA-LIHSPRLAPS-----RDTPVFRPQNYVEKAAINRGWLDSSRSLMEQGI--FEGDIILLRFKFMNFFDLNPKYDPVRINQLYEQAKWSILLDEFDHTEEEATLFAA-LQLQATLQRDSPEPEENN------KDDVDILLDELEQNLDAAALNRRSDLTQVPELADYLKYMK-PKKLAAFKGFKRAFFSFRDLYLSYHQSSSDVNSAPLGHFSLKGCEVSQDVSVGQQKYHIKLLLP--------------TAEGMIDFILKCDSEHQYARWMAACRLASRGKSMAD-SSYQQEVESIKNLLKMQSGNGNENGNSNTASRKAAAVKLPNDFNVDEYISSKYVRRARSKQQIQQRVSDAHGNVRQLTATEAKLQYIRAWQALPEHGIHYFIVRFRNARKAELVAVAVNRLAKLNMDNGESLKTWRFANMKKWHVNWEIRHLKIQFEDE--DIEFKPLSADCKVVHEFIGGYIFLSMRSKEHSQNLDEELFHKLTG 717
BLAST of PH domain-containing protein vs. Ensembl Celegans
Match: unc-112 (pep chromosome:WBcel235:V:14691857:14696654:-1 gene:WBGene00006836.1 transcript:C47E8.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-112) HSP 1 Score: 176.792 bits (447), Expect = 3.542e-46 Identity = 175/741 (23.62%), Postives = 334/741 (45.07%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQW----KELKKLDS-----NTPVPXXXXXXXXXXXXXXXXXXXXXXXXTL-------TSGLNTTGH----RKRFTKPIY--LTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKT--YKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINII---KTTNVSSK----IPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNL--------KMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+ I + +LN +I V + + +L+++ ++ DWS+ W P ++ WL + + Q + +++ F IQLPD+Q+ +DFS F+ + +C+ GIR+ EELSL+ ++L++ S N P+ R + + S L + L+ +GH + T P + L R PSP + I +S +E E F+++ L +SP+ + S +D +++ Y ++A W+ S +LMEQ + + ++ LR+K+ N++ N KYD +RINQ++ Q+ WS++ E D + +E L A L L + E N ++D +LD L +L + N D + E+A ++ +K P+ + + A S + + +++V+S +KG E+ +V + +K I ++ T++ ++ ++ ++ +W A RL S+ S+++ E + + N+++M+S N + K + N+ + I S + + +SK+ I Q+V + L+ EAK+ YI+ W L G HY V + +++ + +RL +++ G + W NWE+ + + F + I FK S +C++ HE++GGY+F+ MR+ E +L+E +F LTG
Sbjct: 17 LPILVTDLNIQRSISVLGNLNVGGLMLELVSECDVERDWSDHALWWPEKRRWLQHTRSTLDQNGITAETQLEFTPMHKEARIQLPDMQMIDARVDFSVNSFKATKKLCRDLGIRYSEELSLKRYIPPEDLRRGTSDADNMNGPLSMRPGEESVGPMTLRKAAPIFASQSNLDMRRRGQSPALSQSGHIFNAHEMGTLPRHGTLPRGV-----SPSPGAYNDTMRRTPIMPSISFSEG--LENEQFDDA-LIHSPRLAPS-----RDTPVFRPQNYVEKAAINRGWLDSSRSLMEQGI--FEGDIILLRFKFMNFFDLNPKYDPVRINQLYEQAKWSILLDEFDHTEEEATLFAA-LQLQATLQRDSPEPEENN------KDDVDILLDELEQNLDAAALNRRSDLTQVPELADYLKYMK-PKKLAAFKGFKRAFFSFRDLYLSYHQSSSDVNSAPLGHFSLKGCEVSQDVSVGQQKYHIKLLLP--------------TAEGMIDFILKCDSEHQYARWMAACRLASRGKSMAD-SSYQQEVESIKNLLKMQSGNGNENGNSNTASRKAAAVKLPNDFNVDEYISSKYVRRARSKQQIQQRVSDAHGNVRQLTATEAKLQYIRAWQALPEHGIHYFIVRFRNARKAELVAVAVNRLAKLNMDNGESLKTWRFANMKKWHVNWEIRHLKIQFEDE--DIEFKPLSADCKVVHEFIGGYIFLSMRSKEHSQNLDEELFHKLTG 717
BLAST of PH domain-containing protein vs. Ensembl Fly
Match: Fit2 (gene:FBgn0036688 transcript:FBtr0075275) HSP 1 Score: 208.764 bits (530), Expect = 4.230e-57 Identity = 180/738 (24.39%), Postives = 340/738 (46.07%), Query Frame = 1
Query: 142 SFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL----QWKELKKLDSNTP----VPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKP--IYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSY--YESFENS------KLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGIL----HHIN---KLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDE---MEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP------IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVD--IIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFK-NSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ + IFI +L +RV I + L++ + K DWS+ W P +WL + Q +Q S ++F +L +QLPDL+ +D+S F +CKQ IR+ EELSL + + LK+ + P VP + Q +S ++ +TG + + P + S ++ SP VSP + ++ L Y Y+S +S L +SP ++ Q + K+ ++A W+ S L++MEQ + +Y+ L LR+KY ++ N K D++RINQ++ Q+ WS+++ E DC+ +E+ + A + HH++ + + D+ ET++ ND + EIDS L L L G D E++ + +K R L YK++ + +++ K S ++ +KG E+ +V + K I + V +R N+Q++ KW A RL +K S+++ E + ++++M+ P + + + V++V+ + II + NK +Q++L + L+ +++K+ YI+ W +L + G + + + + +++G+ ++R++ D+ +G N + +W NW + ++ F + + F +S +C++ HE++GGY+F+ MR+ + LNE +F LTG
Sbjct: 8 SWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDPENPK-DWSDHALWWPARNVWLSRTKLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPG-------TWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRALQ--LRPKSLVEKARLNVGWLDSSLSIMEQGIREYDT--LCLRFKYFTFFDLNPKCDQVRINQLYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSS-QENDNEDEIDSALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGIN-----------SEVWVRCENEQQYAKWMAACRLAAKGRSLAD-SSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNK------AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE--NVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTG 712
BLAST of PH domain-containing protein vs. Ensembl Fly
Match: Fit1 (gene:FBgn0035498 transcript:FBtr0073209) HSP 1 Score: 179.874 bits (455), Expect = 3.884e-47 Identity = 174/728 (23.90%), Postives = 324/728 (44.51%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELS----LQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVS------PVSFFSIFDDLSLNETDLSYYESFEN-----SKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLS-----TNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDE---MEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSK------IPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFK-NSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+ I I +L +RV I V +L++ L DWS+ W P + +WL + + Q +Q S ++F L +Q+PDL+ ++FS F +CK IR+ EELS L+ + LKK S P + + + S + TG + + N SP+ + P+S S N T + Y+S + L SP+ + + +V K+ ++A W+ S L++MEQ V +Y+ L LR+KY ++ N KYD++RINQ++ Q+ WS+++ E + + +ET + A + +N + D+ +T++ D +IDS L+ L L G +D+ E++ ++ +K R L YK++ + +++ K+ + S + I +KG E+ +V + K I + + + V +R N++++ KW A RL +K S++ E + ++++M+ P + + SV +D + + SK + Q++L + LS ++AK+ YI+ W +L + G + + + + +++G+ +R++ D+ TG N + +W NW + ++ + I F S +C++ HE++GGY+F+ MR+ E LNE +F LTG
Sbjct: 11 LRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPLEPEHLKKNFSKLP-------QRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPIS--SPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRAR--LVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDT--LCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGED-DIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIR-----------NGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLAD-SSYDSEVSSIRSLLQMQKPAQGAPLTVNPR---SVEPMDYLSPKMMRKLSSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE--NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTG 705
BLAST of PH domain-containing protein vs. Ensembl Fly
Match: Fit1 (gene:FBgn0035498 transcript:FBtr0073210) HSP 1 Score: 179.874 bits (455), Expect = 3.884e-47 Identity = 174/728 (23.90%), Postives = 324/728 (44.51%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELS----LQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVS------PVSFFSIFDDLSLNETDLSYYESFEN-----SKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLS-----TNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDE---MEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSK------IPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFK-NSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+ I I +L +RV I V +L++ L DWS+ W P + +WL + + Q +Q S ++F L +Q+PDL+ ++FS F +CK IR+ EELS L+ + LKK S P + + + S + TG + + N SP+ + P+S S N T + Y+S + L SP+ + + +V K+ ++A W+ S L++MEQ V +Y+ L LR+KY ++ N KYD++RINQ++ Q+ WS+++ E + + +ET + A + +N + D+ +T++ D +IDS L+ L L G +D+ E++ ++ +K R L YK++ + +++ K+ + S + I +KG E+ +V + K I + + + V +R N++++ KW A RL +K S++ E + ++++M+ P + + SV +D + + SK + Q++L + LS ++AK+ YI+ W +L + G + + + + +++G+ +R++ D+ TG N + +W NW + ++ + I F S +C++ HE++GGY+F+ MR+ E LNE +F LTG
Sbjct: 11 LRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPLEPEHLKKNFSKLP-------QRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPIS--SPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRAR--LVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDT--LCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGED-DIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIR-----------NGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLAD-SSYDSEVSSIRSLLQMQKPAQGAPLTVNPR---SVEPMDYLSPKMMRKLSSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE--NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTG 705
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Match: fermt1 (fermitin family member 1 [Source:ZFIN;Acc:ZDB-GENE-030131-3264]) HSP 1 Score: 212.616 bits (540), Expect = 1.152e-58 Identity = 176/696 (25.29%), Postives = 318/696 (45.69%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYK--TYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFK-NSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+RV + + L+ KI DWS+ W + WLL + ++ +Q + + + + L IQLP+++ +L + FS VF+ ICK IR EELSL LK P + + +++ +T G G + PIY + SPVS S++ + S LT E L + +YK T +D+A W+ S +LMEQ + + + +LLR +KYH ++ N KYD +RI Q++ Q+ W+++ E DC+ +E + A + +HI KL+ + + ++ D E+++ L L L G++ + ED + ++ ++L + R L YK++ V + I+ K + ++K PI +G E+ +V + ++K + ++ + V IR N+ ++ KW A L SK S+++ E + + + ++MKS + E +N + + K FK+K++ ++L + S LS +EAK+ +I+ W +L + G Y V + + +++GI Y+RLI D+ TG+ + + W NWE+ + F ++ I F S +C++ HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 30 LRVKGDLHVGGLMLKLVEKIKAPQDWSDHAIWWEQKSCWLLKTHWTLDKYGIQANADLRYTPQHKSLCIQLPNMKNIKLPVTFSGVVFRAVAEICKTLNIRRTEELSL----LK--------PTDEPKKKKKKDKGTDLATDEILTMDITGG--ALGMYSKTMTPIYDPDSG-------------SPVSSTSLW---------------YGGSPLTACQPNLPPEELAK----LYKPLTMEDKAAINAGWLDSSRSLMEQGIQENDRLLLR--FKYHCFFDLNPKYDAVRITQLYEQARWAILLEEIDCTEEEMLMFASLQYHICKLTLSTEPLDNSDEKEVD---EVEAALSNLETHLEGRNADKILEDITDIPKLEDTLKLFRPKRLTLKPYKEYWFVFRDTTISYFKNKDSANKEPIEQLHLRGCEVIPDVNVTERKFGLKLLLP--------------AADGMNEVYIRCENETQYAKWKAACILASKGKTMAY-SSYRTEVKNIQSFLQMKSLAPPPGQAAPDVESMEMNPECFVSPRYAKKFKTKQLTTRILEAHHNISQLSLMEAKMRFIQAWQSLPDFGIKYYIVRFRGSKKDELLGISYNRLIRIDMSTGLPVTTWRFSNMKQWNVNWEIRQVTIEFDQSV-SIAFSCQSCDCKVVHEYIGGYIFLSTRSKDQNETLDEELFHKLTG 658
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Match: fermt1 (fermitin family member 1 [Source:ZFIN;Acc:ZDB-GENE-030131-3264]) HSP 1 Score: 212.616 bits (540), Expect = 1.152e-58 Identity = 176/696 (25.29%), Postives = 318/696 (45.69%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYK--TYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFK-NSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+RV + + L+ KI DWS+ W + WLL + ++ +Q + + + + L IQLP+++ +L + FS VF+ ICK IR EELSL LK P + + +++ +T G G + PIY + SPVS S++ + S LT E L + +YK T +D+A W+ S +LMEQ + + + +LLR +KYH ++ N KYD +RI Q++ Q+ W+++ E DC+ +E + A + +HI KL+ + + ++ D E+++ L L L G++ + ED + ++ ++L + R L YK++ V + I+ K + ++K PI +G E+ +V + ++K + ++ + V IR N+ ++ KW A L SK S+++ E + + + ++MKS + E +N + + K FK+K++ ++L + S LS +EAK+ +I+ W +L + G Y V + + +++GI Y+RLI D+ TG+ + + W NWE+ + F ++ I F S +C++ HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 30 LRVKGDLHVGGLMLKLVEKIKAPQDWSDHAIWWEQKSCWLLKTHWTLDKYGIQANADLRYTPQHKSLCIQLPNMKNIKLPVTFSGVVFRAVAEICKTLNIRRTEELSL----LK--------PTDEPKKKKKKDKGTDLATDEILTMDITGG--ALGMYSKTMTPIYDPDSG-------------SPVSSTSLW---------------YGGSPLTACQPNLPPEELAK----LYKPLTMEDKAAINAGWLDSSRSLMEQGIQENDRLLLR--FKYHCFFDLNPKYDAVRITQLYEQARWAILLEEIDCTEEEMLMFASLQYHICKLTLSTEPLDNSDEKEVD---EVEAALSNLETHLEGRNADKILEDITDIPKLEDTLKLFRPKRLTLKPYKEYWFVFRDTTISYFKNKDSANKEPIEQLHLRGCEVIPDVNVTERKFGLKLLLP--------------AADGMNEVYIRCENETQYAKWKAACILASKGKTMAY-SSYRTEVKNIQSFLQMKSLAPPPGQAAPDVESMEMNPECFVSPRYAKKFKTKQLTTRILEAHHNISQLSLMEAKMRFIQAWQSLPDFGIKYYIVRFRGSKKDELLGISYNRLIRIDMSTGLPVTTWRFSNMKQWNVNWEIRQVTIEFDQSV-SIAFSCQSCDCKVVHEYIGGYIFLSTRSKDQNETLDEELFHKLTG 658
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 196.052 bits (497), Expect = 1.038e-52 Identity = 186/724 (25.69%), Postives = 339/724 (46.82%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSG------LNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL K D + + + + L G ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V I +K I +I + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLL---RKPRDPKKKKKKLEDAEEETLELEGPLLTPGSASDVLYIGPVKGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPITSPDILV-KMYKPQSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 684
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 192.586 bits (488), Expect = 1.673e-51 Identity = 184/725 (25.38%), Postives = 341/725 (47.03%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ +++ + S ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V + Q +L + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSL----LRKPRD----PKKKKKKLEDAEEETLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPITSPDILV-KMYKPQSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQPGFVRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 680
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 189.504 bits (480), Expect = 2.536e-50 Identity = 184/731 (25.17%), Postives = 337/731 (46.10%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSG------LNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL K D + + + + L G ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V + Q +L + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLL---RKPRDPKKKKKKLEDAEEETLELEGPLLTPGSASDVLYIGPVKGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPITSPDILV-KMYKPQSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQPGFVRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 691
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Match: sh3bgrl3 (SH3 domain binding glutamate-rich protein like 3 [Source:Xenbase;Acc:XB-GENE-965976]) HSP 1 Score: 193.356 bits (490), Expect = 1.011e-51 Identity = 186/719 (25.87%), Postives = 338/719 (47.01%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ ++I + +LN +RV I V L DWS+ W +K WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ + Q T S ++ G + P Y +R+ SP +SP S + F D +L+E + S+ SP+ ++ K YK D+A W+ S +LMEQ V + N+ LL LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS + + N S ++D E+D+ L L L G + D E+ +++ K + L YK++ + I+ K+ S+ P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQF + ++ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +++F + +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 8 GTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKL-------KDWSDHALWWEKKKTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSL----LRKPRD----PTKKKKKKIDDQCEDNILELEGPLLTPGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE------------ILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKE-NDALL-LRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSVMSSENHYNN-SDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESNGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCENEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQFIPDQVNSD-----INPECVVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEM-RLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFFKLT 659
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Match: sh3bgrl3 (SH3 domain binding glutamate-rich protein like 3 [Source:Xenbase;Acc:XB-GENE-965976]) HSP 1 Score: 193.356 bits (490), Expect = 1.119e-51 Identity = 186/719 (25.87%), Postives = 338/719 (47.01%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ ++I + +LN +RV I V L DWS+ W +K WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ + Q T S ++ G + P Y +R+ SP +SP S + F D +L+E + S+ SP+ ++ K YK D+A W+ S +LMEQ V + N+ LL LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS + + N S ++D E+D+ L L L G + D E+ +++ K + L YK++ + I+ K+ S+ P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQF + ++ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +++F + +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 14 GTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKL-------KDWSDHALWWEKKKTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSL----LRKPRD----PTKKKKKKIDDQCEDNILELEGPLLTPGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE------------ILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKE-NDALL-LRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSVMSSENHYNN-SDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESNGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCENEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQFIPDQVNSD-----INPECVVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEM-RLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFFKLT 665
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Match: sh3bgrl3 (SH3 domain binding glutamate-rich protein like 3 [Source:Xenbase;Acc:XB-GENE-965976]) HSP 1 Score: 192.971 bits (489), Expect = 1.454e-51 Identity = 192/735 (26.12%), Postives = 347/735 (47.21%), Query Frame = 1
Query: 103 NMSIDSLKSNRISSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHV----NQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
N+ + S+K N ++ ++I + +LN +RV I V L DWS+ W +K WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ + Q T S ++ G + P Y +R+ SP +SP S + F D +L+E + S+ SP+ ++ K YK D+A W+ S +LMEQ V + N+ LL LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS + + N S ++D E+D+ L L L G + D E+ +++ K + L YK++ + I+ K+ S+ P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQF + ++ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + HV + ++IGI Y+RLI D TG + + W NWE+ + F++ +++F + +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 3 NIPLLSVKEN--GTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKL-------KDWSDHALWWEKKKTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSL----LRKPRD----PTKKKKKKIDDQCEDNILELEGPLLTPGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE------------ILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKE-NDALL-LRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSVMSSENHYNN-SDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESNGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCENEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQFIPDQVNSD-----INPECVVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLQHVLYRFQGGKKEELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEM-RLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFFKLT 668
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Match: sh3bgrl3 (SH3 domain binding glutamate-rich protein like 3 [Source:Xenbase;Acc:XB-GENE-965976]) HSP 1 Score: 188.734 bits (478), Expect = 3.776e-50 Identity = 188/723 (26.00%), Postives = 337/723 (46.61%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHL-----KYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSG--LNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ ++I + +LN +RV I V L+ + L K DWS+ W +K WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ + Q T SG ++ G + P Y +R+ SP +SP S + F D +L+E + S+ SP+ ++ K YK D+A W+ S +LMEQ V + N+ LL LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS + + N S ++D E+D+ L L L G G I + L YK++ + I+ K+ S+ P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQF + ++ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +++F + +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKLLIFVALILLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSL----LRKPRD----PTKKKKKKIDDQCEDNILELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE------------ILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKE-NDALL-LRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSVMSSENHYNN-SDKEVD-EVDAALSDLEITLEG--------------GKTSTIL--KLTLKGYKQYWCTFKDTSISCYKSKEESNGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCENEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQFIPDQVNSD-----INPECVVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEM-RLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFFKLT 662
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Match: sh3bgrl3 (SH3 domain binding glutamate-rich protein like 3 [Source:Xenbase;Acc:XB-GENE-965976]) HSP 1 Score: 188.348 bits (477), Expect = 5.821e-50 Identity = 187/715 (26.15%), Postives = 334/715 (46.71%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++I + +LN +RV I V L DWS+ W +K WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ + Q T S ++ G + P Y +R+ SP +SP S + F D +L+E + S+ SP+ ++ K YK D+A W+ S +LMEQ V + N+ LL LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS + + N S ++D E+D+ L L L G + D E+ +++ K + L YK++ + I+ K+ S+ P ++G E+ +V I +K I +I ++ + +R NQ + W A RL SK S++ E Q + + ++M+ PQF + ++ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +++F + +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 15 LNIHVTDLNRDVTLRVTGEVHIGGVMLKL-------KDWSDHALWWEKKKTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSL----LRKPRD----PTKKKKKKIDDQCEDNILELEGPLLTPGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE------------ILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKE-NDALL-LRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSVMSSENHYNN-SDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESNGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCENQ--YAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQFIPDQVNSD-----INPECVVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEM-RLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFFKLT 660
BLAST of PH domain-containing protein vs. Ensembl Mouse
Match: Fermt2 (fermitin family member 2 [Source:MGI Symbol;Acc:MGI:2385001]) HSP 1 Score: 206.453 bits (524), Expect = 2.855e-56 Identity = 183/711 (25.74%), Postives = 333/711 (46.84%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + + +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A + W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ + +++ D VN ++ + K +KSK+I ++L ++ + +S IEAK+ +I+ W +L G + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLIMPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPVTSPE-ILAKMFKPQALL------DKAKTNQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSREESSGTPAHQLNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPDQITTD-VNPECLVSPRYLKKYKSKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 676
BLAST of PH domain-containing protein vs. Ensembl Mouse
Match: Fermt1 (fermitin family member 1 [Source:MGI Symbol;Acc:MGI:2443583]) HSP 1 Score: 162.155 bits (409), Expect = 3.579e-41 Identity = 129/497 (25.96%), Postives = 238/497 (47.89%), Query Frame = 1
Query: 799 LSYYESFENSKLT--NSPKKSFSEALKQQDIVI----YKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
LS F +S LT N +FS+ D++ ++ D+A W+ S +LMEQ++ + L+LR+KY+ ++ N KYD +RINQ++ Q+ W+++ E DC+ +E + A + +HI+KLS + A S D E+++ L L L G + ED + ++A ++L + + +L K++ V + I K + PI +G EI +V + +K I +I + V +R ++ ++ +W A L SK S+++ E + + ++MK+ + + ++ ++ E +N ++ K KSK++ ++L + + + +EAK+ +I+ W +L G Y V + + I+G+ Y+RLI D TG+ + W NWE+ + F + I F S +C+I HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 200 LSTMTWFGDSPLTEQNCSVLAFSQPPPSPDVLADMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQ--LQLRFKYYTFFDLNPKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISKLSQCAEIQDFATKSEVD---EVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFRPKKLMLKACKQYWFVFKDTSIAYFKNKELEQGEPIEKLNLRGCEIVPDVNVSGRKFGIKLLIP--------------VADGMNEVYLRCDHEDQYARWMAACILASKGKTMAD-SSYQPEVISILSFLKMKN-RNSSPLVASSLENMDMNPECLVSPCCAKKHKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVAYNRLIRIDAVTGIPVTTWRFANMKQWNVNWEIRQVAIEFDQNV-SIAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTG 674 HSP 2 Score: 61.2326 bits (147), Expect = 4.172e-9 Identity = 34/115 (29.57%), Postives = 58/115 (50.43%), Query Frame = 1
Query: 169 ELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
E T +RV I V L+ ++++ DWS++ W ++ WLL + + +Q + + F + +L ++LP+ + +L + FS VF+ ICK IR EELSL
Sbjct: 24 EQQTEITLRVSGDLHIGGVMLKLVEQMNIAQDWSDYALWWEQKRCWLLKTHWTLDKCGVQADANLLFTPQHKMLRLRLPNAKTVRLRVSFSAVVFKAVADICKVLNIRRPEELSL 138
BLAST of PH domain-containing protein vs. Ensembl Mouse
Match: Fermt3 (fermitin family member 3 [Source:MGI Symbol;Acc:MGI:2147790]) HSP 1 Score: 159.844 bits (403), Expect = 1.971e-40 Identity = 109/456 (23.90%), Postives = 222/456 (48.68%), Query Frame = 1
Query: 928 HWMISELTLMEQAV--GDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLD-KEIDSMLDRLHFDLIGKSCNE--DEMEHI-EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNL-----KMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
W+ S LM+Q + GD +L LR+KY++++ + K D +R+ Q++ Q+ W +++ E DC+ +E + A + +HINKL+ + + L+ DL ++D+ L+ L L G + ++ D + I E+ ++ + + + L Y+++ V + ++ K+ + + P +KG E+ +V + +K I ++ + + + +R ++Q++ +W A RL SK S++ E Q + + ++ + K + +N ++ + FK+K++ ++L ++ + LS EA++ +I+ W +L + G Y+ V + + +I+GI +RLI D+ G V + + W NW++ + F E + F S C+I HEY+GGY+F+ R + +L+E +F LTG
Sbjct: 228 RWLDSSRCLMQQGIKAGD----VLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLTEEIDCTEEEMMVFAALQYHINKLTLS---GDVGELASGDLGLDDLDAALNNLEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPGDPTQQLNLKGCEVVPDVNVSGQKFCIKLLVP--------------SPEGMSEIYLRCQDEQQYAQWMAACRLASKGRTMAD-SSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHI-NVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTG 660 HSP 2 Score: 63.5438 bits (153), Expect = 8.505e-10 Identity = 37/128 (28.91%), Postives = 69/128 (53.91%), Query Frame = 1
Query: 139 SSFVISIFIKELNT---THNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
SS+ + +F+ E + + +RV + I V ++ +I+ K DWS+ W ++ WLL + ++ + +++ F + + ++LP+ ++ +L FSK +FQT IC+ IRH EELSL
Sbjct: 14 SSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSL 141
BLAST of PH domain-containing protein vs. Ensembl Mouse
Match: Fermt2 (fermitin family member 2 [Source:MGI Symbol;Acc:MGI:2385001]) HSP 1 Score: 78.1814 bits (191), Expect = 1.926e-15 Identity = 40/125 (32.00%), Postives = 69/125 (55.20%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + + +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL 140
BLAST of PH domain-containing protein vs. Ensembl Mouse
Match: Fermt3 (fermitin family member 3 [Source:MGI Symbol;Acc:MGI:2147790]) HSP 1 Score: 74.7146 bits (182), Expect = 2.123e-13 Identity = 48/188 (25.53%), Postives = 101/188 (53.72%), Query Frame = 1
Query: 931 WMISELTLMEQAV--GDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLD-KEIDSMLDRLHFDLIGKSCNE--DEMEHI-EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNV 1461
W+ S LM+Q + GD +L LR+KY++++ + K D +R+ Q++ Q+ W +++ E DC+ +E + A + +HINKL+ + + L+ DL ++D+ L+ L L G + ++ D + I E+ ++ + + + L Y+++ V + ++ K+ + + P +KG E+ +V
Sbjct: 229 WLDSSRCLMQQGIKAGD----VLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLTEEIDCTEEEMMVFAALQYHINKLT---LSGDVGELASGDLGLDDLDAALNNLEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPGDPTQQLNLKGCEVVPDV 409 HSP 2 Score: 63.1586 bits (152), Expect = 9.467e-10 Identity = 37/128 (28.91%), Postives = 69/128 (53.91%), Query Frame = 1
Query: 139 SSFVISIFIKELNT---THNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
SS+ + +F+ E + + +RV + I V ++ +I+ K DWS+ W ++ WLL + ++ + +++ F + + ++LP+ ++ +L FSK +FQT IC+ IRH EELSL
Sbjct: 14 SSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSL 141
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5R8M5|FERM1_PONAB (Fermitin family homolog 1 OS=Pongo abelii OX=9601 GN=FERMT1 PE=2 SV=1) HSP 1 Score: 213.386 bits (542), Expect = 6.180e-58 Identity = 172/693 (24.82%), Postives = 320/693 (46.18%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+RV + V L+ +I++ DWS+F W + WLL + ++ +Q +K+ F + +L ++LP+L++ +L + FS VF+ ICK IR EELSL LK ++ + + + ++++S + G + PIY P N S + F D L E + S L S SEAL D+ ++ D+A W+ S +LMEQ + + +LLR +KY++++ N KYD +RINQ++ Q+ W+++ E DC+ +E + A + +HI+KLS + +ET + + EI++ L L L G + ED + ++A N++L + + +L +K++ V + I K + P+ +G E+ NV + ++K I +I + + +R ++ ++ +W A L SK S+++ E + + + MK+ ++ + + +D +N + K KSK++ ++L ++ + + +EAK+ +I+ W +L G Y V + + I+G+ Y+RLI D TG+ + W +WE ++ F + + S +C+I HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 31 LRVSGDLHVGGVMLQLVEQINISQDWSDFALWWEQKHCWLLKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKTLNIRRSEELSL----LKPCGDYFKKKKKKDKNNKEPITEDILNLESSPTASVSS--VSPGLYSKTMTPIY------------DPINGTPASSTMTWFSDSPLTEQNCSI--------LAFSQPPQSSEALA--DMYQPRSLVDKAKLNAGWLDSSRSLMEQGIQEDGQLLLR--FKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLS---AETQDFTSESEVDEIEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLLKAFKQYWFVFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPNVNVAERKFGIKLLIP--------------VADGMNEMYLRCDHENQYAQWMAACMLASKGKTMAD-SSYRPEVLNILSFLRMKNRNSASQVASSPENMD-MNPECFVSPRCAKKHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQWNVSWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTG 674
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8CIB5|FERM2_MOUSE (Fermitin family homolog 2 OS=Mus musculus OX=10090 GN=Fermt2 PE=1 SV=1) HSP 1 Score: 206.453 bits (524), Expect = 1.997e-55 Identity = 183/711 (25.74%), Postives = 333/711 (46.84%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + + +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A + W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ + +++ D VN ++ + K +KSK+I ++L ++ + +S IEAK+ +I+ W +L G + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLIMPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPVTSPE-ILAKMFKPQALL------DKAKTNQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSREESSGTPAHQLNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPDQITTD-VNPECLVSPRYLKKYKSKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 676
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9BQL6|FERM1_HUMAN (Fermitin family homolog 1 OS=Homo sapiens OX=9606 GN=FERMT1 PE=1 SV=1) HSP 1 Score: 206.068 bits (523), Expect = 2.167e-55 Identity = 173/693 (24.96%), Postives = 319/693 (46.03%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
+RV + V L+ +I++ DWS+F W + WLL + ++ +Q +K+ F + +L ++LP+L++ +L + FS VF+ ICK IR EELSL LK S +++ ++ + + N T + + G + PIY P N S + F D L E + S S+ SP EAL D+ ++ D+A W+ S +LMEQ + + +LLR +KY++++ N KYD +RINQ++ Q+ W+++ E DC+ +E + A + +HI+KLS + + A S D EI++ L L L G + ED + ++A N++L + + + +K++ + + I K + P+ +G E+ +V + +K I +I + + +R ++ ++ +W A L SK S+++ E + + + MK+ ++ + + +D +N + K KSK++ ++L ++ + + +EAK+ +I+ W +L G Y V + + I+G+ Y+RLI D TG+ + W NWE ++ F + + S +C+I HEY+GGY+F+ R+ ++ L+E +F LTG
Sbjct: 31 LRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSL----LKP--SGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSSVSPGLYSKTMTPIY------------DPINGTPASSTMTWFSDSPLTEQNCSI---LAFSQPPQSP-----EALA--DMYQPRSLVDKAKLNAGWLDSSRSLMEQGIQEDEQLLLR--FKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVD---EIEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVAGRKFGIKLLIP--------------VADGMNEMYLRCDHENQYAQWMAACMLASKGKTMAD-SSYQPEVLNILSFLRMKNRNSASQVASSLENMD-MNPECFVSPRCAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTG 674
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Match: sp|Q96AC1|FERM2_HUMAN (Fermitin family homolog 2 OS=Homo sapiens OX=9606 GN=FERMT2 PE=1 SV=1) HSP 1 Score: 205.297 bits (521), Expect = 4.569e-55 Identity = 183/715 (25.59%), Postives = 335/715 (46.85%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRN--SQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ +S+ + +LN +RV I V L+ K+ +K DWS+ W ++ WLL + ++ +Q +K+ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL ++ + ++ + + L L T G ++ P ++ D + SP +SP S + F D +L+E + S+ SP+ ++ K Q ++ D+A W+ S +LMEQ V + N L LR+KY++++ N KYD IRINQ++ Q+ W+++ E +C+ +E + A + +HINKLS T+ N S ++D E+D+ L L L G + D E+A I++ K + L YK++ + I+ K+ SS P ++G E+ +V I +K I +I ++ + +R N++++ W A RL SK S++ E Q + + ++M+ PQ + + T+ + ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSL---------------LKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSP---LSPTSAW--FGDSALSEGNPGI---LAVSQPITSPE-ILAKMFKPQALL------DKAKINQGWLDSSRSLMEQDVKE--NEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIM-TSENHLNNSDKEVD-EVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHLNPDPQLIPEQITTD-----ITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 676
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Match: sp|F1Q8X5|FERM2_DANRE (Fermitin family homolog 2 OS=Danio rerio OX=7955 GN=fermt2 PE=2 SV=1) HSP 1 Score: 192.586 bits (488), Expect = 1.263e-50 Identity = 184/725 (25.38%), Postives = 341/725 (47.03%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ +++ + S ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V + Q +L + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSL----LRKPRD----PKKKKKKLEDAEEETLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPITSPDILV-KMYKPQSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQPGFVRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 680
BLAST of PH domain-containing protein vs. TrEMBL
Match: A0A2C9JQH7 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106063740 PE=4 SV=1) HSP 1 Score: 256.529 bits (654), Expect = 8.321e-71 Identity = 200/735 (27.21%), Postives = 339/735 (46.12%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL--QW--KELKKL-------------DSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTK--PIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDD-LSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN-EDEMEHI-EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI------KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ ++I + +L +RV I V L+ + + DWS+ W P + WLL + + Q+ +Q +K++F L +QLPDLQ+ +L +DFS F T CK+ GIRH EELS +W ++LKK+ D N P+ +SG G + P+ + S SP+NL + VS +S F+ +S +E S L NSP +A Q + K + ++A W+ S ++L+EQ + + N + L++K++N+Y N KYD IRINQI+ Q+ W++IS E DC+ +E + A + H + S + + D EID+ L L L G + + ++ HI E++ ++ K + L YKK+ A + I +T S PI +G E + +V + K I + + + +RF ++++ +W A +L SK S+++ E Q + + + ++ SP N +N + VN D I + K K++ ++ K++ S +S +EAK+A+IK W +L G Y + + + + +++G+ +R+I D+ TG N L SW NWE+ N +L F K+ F + C+ HE++GGY+F+ MR+++K LNE +F LTG
Sbjct: 14 GSWELNILVTDLQVEKTLRVMGDLHIGGVMVKLVQALDIALDWSDHALWWPDKNKWLLRARSTLDQYNVQADAKLHFTPMHKNLKVQLPDLQVLELSVDFSIKCFATVVQTCKELGIRHPEELSFLRKWDKEDLKKVAKEVHKRKKRGDPDQNGPLSANGTHHN-------------------SSGSLDGGKLSPYPSRSPVGPSPTSTLVRSANSPYNLSTSVSGYSTFNGTMSPGSMHSLSFEGTMESTLANSPFVPAKDAF--QYLYRPKNFAEKARINCAWLDSSISLLEQGIKE--NDFIMLKFKFYNFYDLNPKYDAIRINQIYEQAKWALISEEIDCTEEEMMVFAALQHQVRIQSGLPQPEFDQSQNAQSEDDEIDAALKDLQESLEGSAVSPHGDITHIPELSDYVKFFKPKKLTLKSYKKYFATFKDTFIAFYRTKEESHGPPIMQRIDVRGCEAQPDVNLSAHKYGIKLFVPE--------------PEGMSEICLRFDLEEQYCRWMAACKLASKGKTMAD-SSYEAEVQAIQSFLGLQHPVVSPSHNSPTSSSNV-ITEVNSDDYIAARFFKKVKARSLVSKIMEAHASVQEMSLMEAKLAFIKAWQSLPEFGITYFRIKMANSRKEELMGVASNRIIRMDLNTGDSLKTWRYNTLQSWHVNWEVENVILDFDTE--KVTFASMECSCKTIHEFIGGYIFLSMRSTDKNQSLNEEMFHKLTG 707
BLAST of PH domain-containing protein vs. TrEMBL
Match: A0A1S3J2D1 (fermitin family homolog 2 OS=Lingula unguis OX=7574 GN=LOC106169603 PE=4 SV=1) HSP 1 Score: 247.284 bits (630), Expect = 1.516e-67 Identity = 194/725 (26.76%), Postives = 331/725 (45.66%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEP------SPFNLVSPVSFFSIFDDLSLNE-TDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYK----------KHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSW-ECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ + I + ++ +RV I V L+ + DWS+ W P E +WL + + Q+ + ++++F L +QLPDLQI + DFS +F + ICK+ GIRH EE+SL W+++ + + ++R Q S LT N +G + R Q L P SPF +P S +S LS + LS+ S E S L NSP+ EA + K+Y D+A W+ S +LMEQ + + + VLL+ +K++++Y N KYD +RINQI+ Q W++IS E DC+ +E + A + ++ + D + S N+ +ID+ L L L G HI G+I I ++ L +K K+ + + + K+ ++ P+ KG E++ ++ I +K I I + V IR + ++ KW A +L SK S ++ E Q + + M+ P N +N D + K FK+K+++Q+++ + ++ EAK+ +IK W L G Y V N + +++GI ++R++ D+ G + + +W NWE+ L+ F E ++ FK+ + +C+I HE++GGY+F+ MR+S+K L++ +F LTG
Sbjct: 10 GSWELQILVTDMQVERTLRVKGDLHIGGVMLKLVESLEFAVDWSDHALWWPEENMWLSRTRSTLDQYGVSAEARLHFTPMHKNLKLQLPDLQIMDVRADFSVKIFASVIQICKEMGIRHPEEVSL-WRKVDRDELRNRNNVQKRRRQPDSPSGTLSPGGGGTSPYLTINSNHSGDSGQGG---LFPRTPQGTLLRPGGSTPGSPFTPHTPASPYSYNGTLSPGSMSSLSFEGSLETS-LINSPQTPSREAFNH--LYRPKSYADKAKMNAWWLDSSRSLMEQNIRENDTVLLK--FKFYSFYDLNPKYDAVRINQIYEQGKWALISEEIDCTEEEMMMFAALQLQVSLRANTDQPDGDQSNSTNEEGDDIDAALTDLQVSLEGS--------HITSPGDITRIPELQDYLKFFKPKKLTFKSFKKYWFAFRDTHLVMHKSKETTNGQPLMRVNLKGCEVQPDINITSQKYGIKLFIP--------------GPDGMQEVWIRCETEDQYAKWMAAFKLASKGKTMAD-STYETEVQSIQAFLSMQRP---APAPAVNPNQLDINPEDYVAPRFFKKFKTKQLVQRIVDSHANVRDMTLTEAKLNFIKAWQALPEFGITYFLVKFRNNRKEELVGIAHNRIMKMDLSNGDCLKTWRYSTMKAWNVNWEVREVLVQFEEE--EVAFKSPYADCKIIHEFIGGYIFLSMRSSDKNQTLDQEMFFKLTG 697
BLAST of PH domain-containing protein vs. TrEMBL
Match: A0A0B6ZPD6 (Uncharacterized protein OS=Arion vulgaris OX=1028688 GN=ORF73979 PE=4 SV=1) HSP 1 Score: 244.588 bits (623), Expect = 2.027e-66 Identity = 197/724 (27.21%), Postives = 339/724 (46.82%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTL--TSGLNTTGHRKRFT--KPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNET--DLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHI---NKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSC-NEDEMEHI-EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP------IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ ++I + +L +RV I V L+ + + DWS+ + P WL + + Q+ +Q +K+ F L +QLPDLQ+ +L +DFS F CK+ G+RH EELS L+K D + + + + + + + + + TL + G G + P+ + N+ SP+NL + +S +S F+ + LS+ S E+S L NSP EA Q + K + ++A W+ S +LMEQ + + N + L++K+ N+Y N KYD IRINQI+ QS W++IS E DC+ +E + A + I + L D + + N + D EID+ L L L G + ++ HI E+ ++ K + L YK++ A + I+ ++ S P +KG E + +V + +K I + + + +RF ++ + +W A +L SK S+++ E Q + + M+ SP N L T + D + S + K+K ++ K++ + +S +EAK+AYIK W +L G Y + ++ + + +++GI +R+I D+ +G N L SW NWE+ N +L F K+ F + C+ HE++GGY+F+ MR+++K LNE +F LTG
Sbjct: 12 GSWELNILVTDLQVEKTLRVMGDLHIGGVMVKLVQALDIALDWSDHALYWPERNKWLHRARSTLDQYNVQADAKLQFTPMHKNLKVQLPDLQVLELRVDFSIKCFTAVVQTCKELGVRHPEELSF----LRKWDKDDLKKVAKEVHKRKKRGDPDANGPLSSNGTLHNSQGSLDGGKLSPYPNRSPVGPSPNNTLIRSANSPYNLSTSISGYSTFNGTVSPGSMHSLSFEGSMESS-LANSPPVPAKEAF--QYLYRPKNFAEKARINCAWLDSSTSLMEQGIRE--NDFIMLKFKFFNFYDINPKYDAIRINQIYEQSKWALISEEIDCTEEEMMVFAALQFQIQLQSGLPQPDLDI-SMNAHNHSEDDEIDAALKDLQESLEGSVVTSHGDITHIPELGDYVKFFKPKKLTLKSYKRYYATFKDTFISFYRSKEESQGTPALPRIDVKGCEAQPDVNLSTRKYGIKLFVPE--------------PEGMCEIFLRFEMEEHYCRWMAACKLASKGKTMAD-SSYEAEVQALQTFLGMQHPVVSPTNNSAPLSTTINQADIQSEDYVASKFFRKIKAKSLVGKIMEAHSNVQDMSLLEAKLAYIKAWQSLAEYGITYFRIKMSNSKKEELMGIASNRIIRMDLNSGDSLKTWRYNTLQSWHVNWEVENVILDFDTE--KVTFASMECSCKTIHEFIGGYIFLSMRSTDKNQSLNEEMFHKLTG 708
BLAST of PH domain-containing protein vs. TrEMBL
Match: A0A0L8GYE5 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22025940mg PE=4 SV=1) HSP 1 Score: 244.202 bits (622), Expect = 2.381e-66 Identity = 195/716 (27.23%), Postives = 341/716 (47.63%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWK-ELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKP-IYLTRNSQNDLEEPSPFNLVSPVS--FFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSC--NEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVT--NIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ ++I + +LN +RV I V L+ + + DWS+ W P WL + + Q+++Q +K+ F L IQLP+L I +L +DFS VF ICK+ GIRH EELSL K E + L NT +P + + + + S + +++ S + H R + ++ + S + L SP N + + F L L+ YE L N P K EA ++ KT+ ++A W+ S ++LMEQ + + + LL LR+K+ +Y + KYD +RINQI+ Q+ W++IS E DC+ +E + AG+ + +L + + E + + + +IDS L L L G + + D E+ I++ K + L +K++ V I++ K+ + PI KG E +V + +K I T + + +RF ++ + W A RL SK +++ YE ++ T + M+ P + ++ ++ V +N+ D + + K+ + L+++ + ++S E+K+AYIK W L G Y + +N + ++IG+ +R+I D+++G N L +W NWE +L F E I F + + +C++ HE++GGY+F+ MR+S+K L+E +F LTG
Sbjct: 10 GSWQLNINVTDLNVDIALRVKGDLHIGGVMLQLVEALDIALDWSDHGIWWPARNRWLNRTRSTLDQYEVQADAKLEFTPMHKPLQIQLPNLSIIELPVDFSCNVFGAVIQICKKCGIRHPEELSLMRKLEKEDLKKNTLIPVQHKRHRQKQPMSPYVDSPNSHNNSSNSLDFYSPHSNRSPQSTLHHSPGSVHSLSSNSPQNTFNANNSYFAGSMHSLHLD----GGYEQI----LLNGPHKPTKEAFNL--LLRPKTFAEKARMNKGWLDSSISLMEQGIRERH--LLLLRFKFFTFYDLSPKYDSVRINQIYEQAKWALISEEIDCTEEEMVMFAGLQLQV-QLESQNPQPEIFDQTDGQEEDDIDSALKELKESLEGTTAPSSNDITNVPELDAFIKIFKPKKFTLKNFKRYYCVFREYTISLYKSKEDRAGEPIARISTKGCEASPDVNLSSQKFGIKLFEP--------------TKEGMSEIWLRFDTKELYCDWMAACRLASKG---KTMADSTYESEVTTLKTFLSMQEPAADDSIVSSSGSVPDINVEDFVAPRFVRKLKAGQFLKRIKEAHSNVKNMSLTESKMAYIKAWQALPEYGITYFIIKMNNMKKEELIGVANNRIIRMDLQSGDSVKTWRYNTLQTWTVNWETRQVILKFEEE--NIIFDSPAADCKVVHEFIGGYIFLSMRSSDKNQTLDEALFHKLTG 693
BLAST of PH domain-containing protein vs. TrEMBL
Match: C3ZKQ8 (PH domain-containing protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_285279 PE=4 SV=1) HSP 1 Score: 237.269 bits (604), Expect = 4.350e-64 Identity = 192/727 (26.41%), Postives = 331/727 (45.53%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTG-HRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNE-----TDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHIN---KLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNE---DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLV-------DIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ +++ + +L +RVD +I V L+ + + DWS+ FW P +WLL + + +Q ++++F L +QLPDLQ+ L +DFS F +C GIRH EELS +KK+D T L G +K+ K LT + PS +N V ++ +S + D Y + S L+ SP K SEA+ + K Y DRA W+ S +LMEQ + + N+++L LR+KY++++ N KYD +RINQI+ Q+ WS+++ +C+ +E + A + +N + D N+ ND +ID+ L L L G + N D + E+A + K + L YK++ + + + +S PI +G E+ +V I +K I +I +++ V IR ++ ++ +W A RL +K + ++ E Q +TN + ++ P+ + V SVN+ D + H K FK+K + ++L + ++L+ +EAK+ YI+ W L G + V N + ++G+ ++R++ D+ TG N + W NWE+ L+ F + +++F S +C+I HE++GGY+F MR+ ++ LNE +F LTG
Sbjct: 10 GSWELNVLVTDLKAERKLRVDGDMSIGNVMIKLVESLDVAMDWSDHGFWWPQRNMWLLRTHWTLDKCGVQADAQLHFTPTHKNLRVQLPDLQLVDLKVDFSYMAFNAIMNVCAMLGIRHPEELSF----MKKVDERT----------------------------LKRGEKRGSFKKKKGEKSGPLTPGTPLTPGTPSGYNTYPRVPSYNGTSPVSSSYSLSSFPDSPYSDGSNISALSISPAKPSSEAVAT--LHRPKNYVDRARLNSLWLNSSRSLMEQGIRE-NDIIL-LRFKYYSFFDLNPKYDAVRINQIYEQAKWSLLTEGIECTEEEAMMFAALQLQVNLQSAMPQPDMNNA------NDSTDDIDAALTDLQVSLEGSAKNSAAGDITQIPELADWLRFFKPKKFTLKSYKRYWFTFKDTHLAYYHSPEEASGAPIMRVNLRGCEVTPDVNISSEKYCIKLLIP--------------STEGMNEVWIRADSETQYARWMAACRLAAKGKTMAD-ATYESEVQSITNFLGLQHPK---------EPVPSVNVSNINIEPQDFVSQRHVKKFKAKSLTARILEAHANVANLALMEAKLNYIRAWQALPEFGITHFVVRFRGNKKEDLLGVAFNRIMRMDLHTGDALKTWRYNSMKHWNVNWEVKEVLVQFEDE--QVSFACLSADCKIVHEFIGGYIFNSMRSKDQNQTLNEELFHKLTG 668
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 170.629 bits (431), Expect = 2.203e-44 Identity = 174/718 (24.23%), Postives = 323/718 (44.99%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK T S ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L K++ + I+ K+ + IP ++G E+ +V I +K I +I + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D T + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNKDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMKVKVNFSDRVFKAVSDICK---------------------------------------------------TFRSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPISSPDILV-KLYKPPSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNALGDITSIPELADYVKVFKPKKLTLKGPKQYWCTFKDITISCYKSREEAHGIPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VADGMNEIWLRCDTERQYAQWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGSKREELIGITYNRLIRIDASTRDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 630
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 164.081 bits (414), Expect = 3.901e-42 Identity = 172/725 (23.72%), Postives = 321/725 (44.28%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +LN ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + +L +QLP+++ ++ ++FS VF+ ICK T S ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A W+ S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS +++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L K++ + I+ K+ + IP ++G E+ +V + Q +L + + +R ++++ +W A RL SK S++ E Q + + ++M+ PQ ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D T + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLNKDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMKVKVNFSDRVFKAVSDICK---------------------------------------------------TFRSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPISSPDILV-KLYKPPSLLDKAKINQGWLDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNALGDITSIPELADYVKVFKPKKLTLKGPKQYWCTFKDITISCYKSREEAHGIPAHQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTERQYAQWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQI-IEPITTD-----INPECLVSPRYLKKYKNKQPGYIRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGSKREELIGITYNRLIRIDASTRDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 637
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Match: fermt3a (fermitin family homolog 3 [Source:NCBI gene;Acc:103039629]) HSP 1 Score: 161.77 bits (408), Expect = 2.794e-41 Identity = 117/455 (25.71%), Postives = 221/455 (48.57%), Query Frame = 1
Query: 907 DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHI---EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
D+A W+ S +L++Q V + + ++LR +KY++++ ++D +R+ Q++ Q+ W+++ E DC+ +E L A + +HI K+ST T A+ D ++DS L L + ++ E+ +E + E+ ++L + + L YK+ + I+ K+ S K PI KG E+ +V + +K I +I + V +R N+Q++ KW A RL SK S + E Q + + + M+ K ++++ +S+N ++ + K +K K++ ++L ++ + LS EA + +++ W L + G Y V + +++GI +RLI D+ V N + W NW++ + F+ I F + +C+I HEY+GGY+F+ R+ E+ LNE +F LTG
Sbjct: 208 DKAQVNGRWLDSSRSLLQQGVKEGDKLILR--FKYYSFHDLAPQFDAVRLTQLYEQAKWAILLEEIDCTEEEMMLFAALQYHIGKVST--TEQLVASCPAMD---DLDSALQCLEVKMEAETSAEEMLETMTAPELHDYLKLFRPKKQTLKKYKQFWFTFKDTSISYYKSKEESCKEPIQQMNLKGCEVAPDVSVAAQKFCIRLLIPE--------------PEGMNEVYLRCDNEQQYSKWMAASRLASKGKTLADAS-YSSEVQSIQSFLAMQKTTPGNKTVQSD---ESINTHSLVSPRYQKKYKPKQLTPRILEAHQNVAQLSLTEAILKFLQIWQALPDFGLSYFVVRFKGCRKDEVLGIANNRLIRIDLSVEDVVKTWRYNTMRQWNVNWDIKQVAIEFNGNV-NIAFSCVTADCKIVHEYIGGYIFMSTRSREQNDTLNEELFHKLTG 636 HSP 2 Score: 55.8398 bits (133), Expect = 1.461e-7 Identity = 37/124 (29.84%), Postives = 60/124 (48.39%), Query Frame = 1
Query: 151 ISIFIKELNTTH---NIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
+S+ ++EL I V I V ++ K +K DWS+ W ++ WLL + + + + +++ + L + LP+L +L + FS VF+T ICK IRH EELSL
Sbjct: 6 LSVNVEELGEEAPPLKISVTSDLHIGGVILKIVEKTEIKKDWSDHALWWEQKQQWLLKPAWTLDKCGIHADARLYLTPQHKPLRLVLPNLLTLRLRVCFSSPVFRTVIGICKLLNIRHPEELSL 129
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Match: fermt1 (fermitin family member 1 [Source:NCBI gene;Acc:103022983]) HSP 1 Score: 160.229 bits (404), Expect = 9.673e-41 Identity = 119/446 (26.68%), Postives = 222/446 (49.78%), Query Frame = 1
Query: 931 WMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
W+ S +LMEQ + + + +LLR +KYH ++ N KYD +RI Q++ Q+ W+++ E +C+ +E + A + +HI KL+ + + ++ D+D E+++ L L L G++ + ED + ++ ++L + P+ +L +K + V + I+ K +S PI +G E+ +V + +KK I ++ + V IR N+ ++ KW A L SK S++ E + + + ++MKS ++ E +N + + K +K+K++ ++L + S LS +EAK+ +I+ W +L G Y V + +I+GI Y+RLI D T + + + W NWE+ + F + W S +C++ HEY+GGY+F+ R+ ++ L+E +FR LTG
Sbjct: 235 WLDSSSSLMEQGIQENDKLLLR--FKYHCFFDLNPKYDAVRITQLYEQARWAILLEEIECTEEEMLMFASLQYHICKLTMSTKPVDYSD--EPDID-EVEAALSHLETTLEGRNTDKILEDITDIPKLEDTLKLYR-PKRLLRTFKDYWFVFKDTSISYYKNKESASGEPIEQLHLRGCEVVPDVNVTEKKFGIKLLLP--------------VADGMNEVYIRCDNETQYAKWKAACILASKGKTMAY-SSYGSEVRNIQSFLQMKSLAPPPGQAASDVESMEMNPECFVSPRYGKKYKNKQLSTRILDAHHNISQLSLMEAKMRFIQAWQSLPEFGIKYYIVRFRGCKKDEILGISYNRLIRIDTSTRLPVTTWRFSNMKQWNVNWEIRQVSIEFDQNVWVAFSCQSCDCRVVHEYIGGYIFLSTRSKDQNETLDEELFRKLTG 659 HSP 2 Score: 58.151 bits (139), Expect = 2.741e-8 Identity = 31/100 (31.00%), Postives = 51/100 (51.00%), Query Frame = 1
Query: 214 ISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
I + L+ KI +WS+ W + WLL + ++ +Q + + F + L +QLP+++ +L + FS VF+ + ICK IR EELSL
Sbjct: 38 IGGLMLKLVEKIKTPQNWSDHALWWEKKNCWLLKNHWTLDKYGVQADADLRFTPQHKPLLLQLPNMKTIKLTISFSSVVFKAVEEICKALNIRRSEELSL 137
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Match: fermt3a (fermitin family homolog 3 [Source:NCBI gene;Acc:103039629]) HSP 1 Score: 159.458 bits (402), Expect = 1.837e-40 Identity = 117/452 (25.88%), Postives = 217/452 (48.01%), Query Frame = 1
Query: 907 DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
D+A W+ S +L++Q V + + ++LR +KY++++ ++D +R+ Q++ Q+ W+++ E DC+ +E L A + +HI K+ST T A+ D ++DS L L + ++ E E + + N L + + L YK+ + I+ K+ S K PI KG E+ +V + +K I +I + V +R N+Q++ KW A RL SK S + E Q + + + M+ K ++++ +S+N ++ + K +K K++ ++L ++ + LS EA + +++ W L + G Y V + +++GI +RLI D+ V N + W NW++ + F+ I F + +C+I HEY+GGY+F+ R+ E+ LNE +F LTG
Sbjct: 220 DKAQVNGRWLDSSRSLLQQGVKEGDKLILR--FKYYSFHDLAPQFDAVRLTQLYEQAKWAILLEEIDCTEEEMMLFAALQYHIGKVST--TEQLVASCPAMD---DLDSALQCLEVKMEAETSAE---EMLSVKPNSYLHRPKKQTLKKYKQFWFTFKDTSISYYKSKEESCKEPIQQMNLKGCEVAPDVSVAAQKFCIRLLIPE--------------PEGMNEVYLRCDNEQQYSKWMAASRLASKGKTLADAS-YSSEVQSIQSFLAMQKTTPGNKTVQSD---ESINTHSLVSPRYQKKYKPKQLTPRILEAHQNVAQLSLTEAILKFLQIWQALPDFGLSYFVVRFKGCRKDEVLGIANNRLIRIDLSVEDVVKTWRYNTMRQWNVNWDIKQVAIEFNGNV-NIAFSCVTADCKIVHEYIGGYIFMSTRSREQNDTLNEELFHKLTG 642 HSP 2 Score: 55.8398 bits (133), Expect = 1.359e-7 Identity = 37/124 (29.84%), Postives = 60/124 (48.39%), Query Frame = 1
Query: 151 ISIFIKELNTTH---NIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
+S+ ++EL I V I V ++ K +K DWS+ W ++ WLL + + + + +++ + L + LP+L +L + FS VF+T ICK IRH EELSL
Sbjct: 18 LSVNVEELGEEAPPLKISVTSDLHIGGVILKIVEKTEIKKDWSDHALWWEQKQQWLLKPAWTLDKCGIHADARLYLTPQHKPLRLVLPNLLTLRLRVCFSSPVFRTVIGICKLLNIRHPEELSL 141
BLAST of PH domain-containing protein vs. Ensembl Sea Lamprey
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:553051]) HSP 1 Score: 222.631 bits (566), Expect = 6.836e-63 Identity = 175/709 (24.68%), Postives = 337/709 (47.53%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIG---KSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVS---SKIPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNS-WECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
++ + I + +L +RV I V L+ ++ +K DWS+ W + WLL + ++ +Q + ++F + ++ +QLP ++ ++ ++FS VF+ ICK F IRH EELSL K DS+ + + + + ++ ++ G + P Y R+ SP +SP + + F D L E + S + L N+ + + + Q ++ D+A W+ S +LMEQ + D N +L LR+KY++++ N KYD IRINQ++ Q+ W+++ + +C+ +E + A + +HINKLS AN S ++D E+D+ L L L G S D M+ E++ +++ + + L YK++ V + I+ + + +I ++G E+ +V I +K I ++ ++ V +R +++++ +W A RL SK S++ E + ++M++ + + + + V +N + + K +K+K++ ++L ++ SH+S +EAK+ +I+ W +L G + V + +++GI Y+RLI D+ TG + + W NWE+ + F + +I F S +C++ HE++GGY+F+ R ++ L+E +F LTG
Sbjct: 15 GTWELRILVTDLQQEVMMRVTGELHIGGVMLRLVERLEMKKDWSDHALWWERKTTWLLKTHWTLDKYGIQADATLHFTPQHKLMRLQLPSMKYVRVKVNFSDLVFKAVVDICKTFNIRHPEELSLI---RKPQDSSKKKKKKGGEENNHEEVTELEGPLITPTASPGGPFSSPGWYSKTMTPTYDARDG-------SP---LSPTTAW--FGDSPLAEGNPSALAA----ALPNTSPEVLARMYRPQTLL------DKARINGGWLDSSRSLMEQGIKD--NDILMLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEDIECTEEEMMMFAALQYHINKLSL--MTEGHANHSEQEVD-EVDAALSDLEIALEGGRSSSGLRDIMKIPELSDYLKMFRPKKLTLKGYKQYWFVFKDTAISYYRNKDDPRPVQQITLRGCEVIPDVNIAAQKFNIKLLVP--------------VTEGMTEVWLRCESEKQYAEWMAACRLASKGKTMAD-SSYAGEVNSILTFLKMQNVSLEPQSI-SPQNVPDINPESFVCPRYMKKYKAKQLTARILEAHQNVSHMSLVEAKMRFIQAWQSLPEFGITHFVVRFRGAKKEEMMGIAYNRLIRMDLSTGDAIKTYRFSNMKQWNVNWEVRQVAVEFDDEM-QIAFHCSDADCKVVHEFIGGYIFLSTRAKDQNEALDEELFHKLTG 676
BLAST of PH domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002438.1 (pep scaffold:Pmarinus_7.0:GL480979:127958:159017:1 gene:ENSPMAG00000002171.1 transcript:ENSPMAT00000002438.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 196.438 bits (498), Expect = 1.197e-53 Identity = 173/713 (24.26%), Postives = 320/713 (44.88%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHL--KYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLH--FDLIGKSCNEDEMEHI-EIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ +S+ I +L +R+ I + ++ + DWS+ W KLWLL + ++ +Q + + F + +L +QLP + ++ + FS VF+ IC+ IRH EELSL L+K + T + + G T G + P+Y T++ +P S F + L + LS + E + P + +Q+ + D+A W+ S +LMEQ V + ++++LR YKY ++ N KYD IRINQ++ Q+ W ++ + DC+ +E + A + +HI+KLS + + S D+D +DS L L ++ S ++ I ++ I++ K R L YK + V + I K S+ +P+ KG E+ +V I ++ I +I + + +R N++++ +W A RL SK S++ E + + + MK ++++ + + + + K K+K++ +++ ++ ++L+ +EAK+ +I+ W +L + G + V + + +GI Y+R+I D+ TG N + W NWE+ ++ F E KI F S +C++ HEY+GGY+F+ R+ E+ +L+E +F LTG
Sbjct: 19 GSWELSVNITDLERPVTVRLKGDLHIGGLILRIVQAAGADEQRDWSDHALWWEHRKLWLLKHPWTLDKYGVQANAVLVFTPQHKLLRLQLPSSKRVRVTVSFSDPVFRAVADICRTCNIRHPEELSL----LRKPEDPT--------KKKKKDKETTDDLLEPLIQASGKGAGTQGLYSKTMTPMYDTKDG-------TPL-----ASTAQWFGNDGLTDGGLSVLATSEAA-----PADVLARRYRQESLA------DKARINGGWLDSSRSLMEQGVKEKDSLMLR--YKYFCFFDINPKYDAIRINQLYEQARWGILLEKVDCTEEEMMMFAALQYHISKLSASPEIRKVE--SEPDVDA-VDSALSDLEVALEVNNPSVPLGDLTSIPQLNDYIKVFKPKRLTLKGYKLYWCVFKDTCITCYKNKEDSTGVPLQTMNLKGCEVAPDVNISGQRFNIKLMIP--------------VPEGMNEIWLRCDNEEQYGRWMAACRLASKGKTMAD-SSYHGEVDSILSFLRMKQISPDVQISSQSISAADMTPECFVSPRYAKKIKTKQLAARIMEAHQNVANLALVEAKMKFIQAW-SLPDFGIAHFVVRFRGSKKDDALGIAYNRIIRQDVNTGEPIKTWRFNNMKQWNVNWEVKQVIIEFDEEV-KIGFNCISADCKVVHEYIGGYIFMSTRSKEQDDNLDEELFHKLTG 674
BLAST of PH domain-containing protein vs. Ensembl Nematostella
Match: EDO36565 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIB3]) HSP 1 Score: 173.711 bits (439), Expect = 8.570e-46 Identity = 173/712 (24.30%), Postives = 309/712 (43.40%), Query Frame = 1
Query: 151 ISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSP-FNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNI-ELIKYPRNILSLYKKH-SAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHV--NQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNET----IFRSLTG 2244
+S+FI L+T + V I K+ DL+ + + DWS+ W P + WLL + +Q +K++F + +QLPDLQ +L +DFSK VF Q +C + GIRH EELSL K KL + + + G +KR + + S SP ++ P FS ++ +LN+ SP EAL + K+ +++A W+ S +LMEQ V +++ + LRYKY+ ++ N K DEIRINQ++ Q+ WS+++ E +C+ +E A I + LS S +N+ P D D +ID+ L L L G S + + + E++ Y + + KH + S+ + + K+ + P+ +G E+ +V + K I + + E +++ + ++ KW A R+ SK +S ++ E + + M+ + + L + + D +G K +K K+I ++L + S +E+K+ YI+ W +L G + V ++ + +I+GI ++R++ D T + + +W NWE ++ + N ++ + + HE++GGY+F+ MR D+N+ +F LTG
Sbjct: 12 LSVFITSLSTEKPVEVTGQTHIGKLMLDLVEGLDISADWSDHGLWWPQRRQWLLKPRITLDTCGVQGDAKLHFTPIHKKVRVQLPDLQFVELSMDFSKKVFVAVQELCAELGIRHPEELSLM-KPNNKLKKD-------------------------------ARRSMKGKKKRHSG----SGISPGSASPGSPAYSNFGPEGPFSTLENTNLNQ----------------SPLTPSQEALNT--LCKPKSIQEKAYLNSGWLDSSRSLMEQEVQEFDTIY--LRYKYYTFFDLNPKVDEIRINQLYEQAKWSILTEEVECTEEEMMSFAAIQFQVKILSA----SPQSNI-PED-DDDIDAALSDLQLTLEGSSHSTTSPAKVNSLNTVPEIMDYLNLVNNCDVKHFLSADSDTTLTVYKSQEEAFGQPVQRMNLRGCEVTTDVNVSKDKYQIRMRL-----------------QDNEEIELACSTESQYAKWMAACRMASKGKTMADIS-YESEKAGIQAFLSMQHDKGDGTPLSPGQ--IHIQPEDFVGQRMLKKYKPKQIAARILESHTALHKASLVESKMMYIRQWQSLPEFGVSHFIVRFRSDKPKKEEILGIAFNRIMRIDASTREAIKTWRYSVMRAWNVNWETREMIVQCEDEMIAFNCVSA-DIKAVHEFIGGYIFLSMRK-----DVNQPPSDELFYKLTG 635
BLAST of PH domain-containing protein vs. Ensembl Medaka
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:101155069]) HSP 1 Score: 198.749 bits (504), Expect = 1.179e-53 Identity = 188/724 (25.97%), Postives = 339/724 (46.82%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSG------LNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +L+ ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + VL +QLP+++ ++ ++FS VF+ ICK F IRH EELSL K D + + + + + G ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A WM S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS T++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V I +K I +I + + +R ++++ W A RL SK S++ E Q + + ++M+ PQF ++ + T+ +N ++ + K +K+K+I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLHRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKVLRLQLPNMKHMKVKVNFSDRVFKAVSDICKTFNIRHPEELSLL---RKPRDPKKKKKKLEEAEEDDLELEGPLLTPGSASEIIYIGPVKGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPISSPDILV-KLYKPQSLLDKAKINQGWMDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSTDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSKEEAHGTPSYQMNLRGCEVTPDVNISGQKFNIKLLIP--------------VADGMNEIWLRCDTEKQYAHWMAACRLASKGKTMAD-SSYNLEVQNILSFLKMQHMNPDPQF-IEPITTD-----INPECLVSPRYLKKYKNKQISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKEELIGITYNRLIRMDAHTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 684
BLAST of PH domain-containing protein vs. Ensembl Medaka
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:101155069]) HSP 1 Score: 195.667 bits (496), Expect = 1.075e-52 Identity = 187/725 (25.79%), Postives = 342/725 (47.17%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +L+ ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + VL +QLP+++ ++ ++FS VF+ ICK F IRH EELSL L+K P +++ ++++ + S ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A WM S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS T++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V + Q +L + + +R ++++ W A RL SK S++ E Q + + ++M+ PQF ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLHRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKVLRLQLPNMKHMKVKVNFSDRVFKAVSDICKTFNIRHPEELSL----LRKPRD----PKKKKKKLEEAEEDDLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPISSPDILV-KLYKPQSLLDKAKINQGWMDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSTDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSKEEAHGTPSYQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAHWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQF-IEPITTD-----INPECLVSPRYLKKYKNKQPGYIRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKEELIGITYNRLIRMDAHTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 680
BLAST of PH domain-containing protein vs. Ensembl Medaka
Match: fermt2 (fermitin family member 2 [Source:NCBI gene;Acc:101155069]) HSP 1 Score: 191.43 bits (485), Expect = 3.726e-51 Identity = 186/731 (25.44%), Postives = 337/731 (46.10%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSG------LNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYK-----DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDL-IGKSCNE--DEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIP-----IKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMK----SPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKE-------ILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLT 2241
++ + + + +L+ ++RV I V L+ K+ +K DWS+ W +K WLL + ++ +Q +++ F + VL +QLP+++ ++ ++FS VF+ ICK F IRH EELSL K D + + + + + G ++ G + P Y +R+ SP +SP S + F D L+E + S + S+ + DI++ K YK D+A WM S +LMEQ V + N VLL LR+KYH+++ N KYD IR+NQ++ Q+ W+++ E +C+ +E + A + +HINKLS T++ N S ++D E+D+ L L L GK+ N D E+A +++ K + L YK++ + I+ K+ + P ++G E+ +V + Q +L + + +R ++++ W A RL SK S++ E Q + + ++M+ PQF ++ + T+ +N ++ + K +K+K+ I ++L ++ + +S IEAK+ +I+ W +L G + + ++IGI Y+RLI D TG + + W NWE+ + F++ +C++ HE++GGY+F+ R ++ L+E +F LT
Sbjct: 16 GTWELKMHVTDLHRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKVLRLQLPNMKHMKVKVNFSDRVFKAVSDICKTFNIRHPEELSLL---RKPRDPKKKKKKLEEAEEDDLELEGPLLTPGSASEIIYIGPVKGSIYSSPGLYSKTMTPTYDSRDG-------SP---LSPTSAW--FGDSPLSEGNPSIL--------------AVSQPISSPDILV-KLYKPQSLLDKAKINQGWMDSSRSLMEQDVKE-NEVLL-LRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSTDNHMNN-SEKEVD-EVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSKEEAHGTPSYQMNLRGCEVTPDV--------------NISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAHWMAACRLASKGKTMA-DSSYNLEVQNILSFLKMQHMNPDPQF-IEPITTD-----INPECLVSPRYLKKYKNKQPGYIRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKEELIGITYNRLIRMDAHTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLT 691
BLAST of PH domain-containing protein vs. Ensembl Medaka
Match: fermt1 (fermitin family member 1 [Source:NCBI gene;Acc:101160280]) HSP 1 Score: 174.481 bits (441), Expect = 1.837e-45 Identity = 125/454 (27.53%), Postives = 222/454 (48.90%), Query Frame = 1
Query: 907 DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
D+A + W+ S +LMEQ V + +LLR +KY+ ++ N KYD +RI Q++ Q+ W+++ E DC+ +E + A + +HI KL+ + + AN D E+++ L L L G + ED + ++A + L + L YK++ V + I+ K SS PI +G E+ +V + DKK I +I + V IR N+ ++ KW A L SK S++K E + + + ++MKS + + +N + + K K+K++ ++L ++ +HLS ++AK+ +IK W +L G Y V + + +I+GI Y+RLI D+ TG+ + W NWE+ ++ F ++ S +C++ HE++GGY+F+ R+ ++ L+E +F LTG
Sbjct: 229 DKATNNAGWLDSSRSLMEQDVQSSDRLLLR--FKYNVFFDLNPKYDAVRITQLYEQARWAILLEEIDCTEEEMLMFASLQYHICKLTMSSEPRDNANEPEVD---EVEAALSNLEVTLEGSHTDKFLEDITDIPQLADTLRLFRPKWLTLRPYKEYWFVFKDTNISYYKNKEASSGEPIEQFHLRGCEVVPDVNVTDKKFGIKLLIP--------------VADGMNEVYIRCDNEMQYAKWKAACILASKGKTMAY-SSYKSEVKNIHSFLQMKSLAPPPGHATPDVDAMEMNAESFVSPRYAKKQKTKQLTTRILEAHQNIAHLSLMDAKMRFIKAWQSLPEFGIKYYIVRFKGSKKDEILGISYNRLIRIDMSTGLPVTTWRFANMKQWNVNWEVRQVMIEFDQSVSIAFCCLSCDCKVVHEFIGGYIFLSTRSKDQNETLDEDLFVKLTG 662 HSP 2 Score: 61.2326 bits (147), Expect = 3.335e-9 Identity = 33/108 (30.56%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
+RV + + L+ KI DWS+ W K WLL + ++ +Q + + + + L +QLP+++ ++ + FS VF+T IC+Q IR EELSL
Sbjct: 31 LRVAGDLHVGGLMLKLVEKIKAPQDWSDHALWWEQRKCWLLKTHWTLDKYGIQADADLRYTPQHKPLLLQLPNMKTIKINVCFSSMVFKTVSDICRQLNIRRPEELSL 138
BLAST of PH domain-containing protein vs. Ensembl Medaka
Match: fermt1 (fermitin family member 1 [Source:NCBI gene;Acc:101160280]) HSP 1 Score: 174.481 bits (441), Expect = 1.837e-45 Identity = 125/454 (27.53%), Postives = 222/454 (48.90%), Query Frame = 1
Query: 907 DRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCN---EDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPI-----KGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
D+A + W+ S +LMEQ V + +LLR +KY+ ++ N KYD +RI Q++ Q+ W+++ E DC+ +E + A + +HI KL+ + + AN D E+++ L L L G + ED + ++A + L + L YK++ V + I+ K SS PI +G E+ +V + DKK I +I + V IR N+ ++ KW A L SK S++K E + + + ++MKS + + +N + + K K+K++ ++L ++ +HLS ++AK+ +IK W +L G Y V + + +I+GI Y+RLI D+ TG+ + W NWE+ ++ F ++ S +C++ HE++GGY+F+ R+ ++ L+E +F LTG
Sbjct: 229 DKATNNAGWLDSSRSLMEQDVQSSDRLLLR--FKYNVFFDLNPKYDAVRITQLYEQARWAILLEEIDCTEEEMLMFASLQYHICKLTMSSEPRDNANEPEVD---EVEAALSNLEVTLEGSHTDKFLEDITDIPQLADTLRLFRPKWLTLRPYKEYWFVFKDTNISYYKNKEASSGEPIEQFHLRGCEVVPDVNVTDKKFGIKLLIP--------------VADGMNEVYIRCDNEMQYAKWKAACILASKGKTMAY-SSYKSEVKNIHSFLQMKSLAPPPGHATPDVDAMEMNAESFVSPRYAKKQKTKQLTTRILEAHQNIAHLSLMDAKMRFIKAWQSLPEFGIKYYIVRFKGSKKDEILGISYNRLIRIDMSTGLPVTTWRFANMKQWNVNWEVRQVMIEFDQSVSIAFCCLSCDCKVVHEFIGGYIFLSTRSKDQNETLDEDLFVKLTG 662 HSP 2 Score: 61.2326 bits (147), Expect = 3.335e-9 Identity = 33/108 (30.56%), Postives = 55/108 (50.93%), Query Frame = 1
Query: 190 IRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSL 513
+RV + + L+ KI DWS+ W K WLL + ++ +Q + + + + L +QLP+++ ++ + FS VF+T IC+Q IR EELSL
Sbjct: 31 LRVAGDLHVGGLMLKLVEKIKAPQDWSDHALWWEQRKCWLLKTHWTLDKYGIQADADLRYTPQHKPLLLQLPNMKTIKINVCFSSMVFKTVSDICRQLNIRRPEELSL 138
BLAST of PH domain-containing protein vs. Planmine SMEST
Match: SMESG000025860.1 (SMESG000025860.1) HSP 1 Score: 1338.55 bits (3463), Expect = 0.000e+0 Identity = 716/717 (99.86%), Postives = 717/717 (100.00%), Query Frame = 1
Query: 106 MSIDSLKSNRISSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTGRNAD 2256
MSIDSLKSNRISSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPNRRRISQSVSQQNVRQSSNRNRDSTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWS+ISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPIKGNEIRLNVKIRDKKIFIIEIILLKNNQNNKNELNNKTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTGRNAD
Sbjct: 1 MSIDSLKSNRISSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKKLDSNTPVPNRRRISQSVSQQNVRQSSNRNRDSTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSIFDDLSLNETDLSYYESFENSKLTNSPKKSFSEALKQQDIVIYKTYKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSVISGETDCSADETYLLAGILHHINKLSTNDTNSETANLSPNDLDKEIDSMLDRLHFDLIGKSCNEDEMEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPIKGNEIRLNVKIRDKKIFIIEIILLKNNQNNKNELNNKTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTGRNAD 717
BLAST of PH domain-containing protein vs. Planmine SMEST
Match: SMESG000020711.1 (SMESG000020711.1) HSP 1 Score: 191.43 bits (485), Expect = 2.960e-51 Identity = 186/737 (25.24%), Postives = 325/737 (44.10%), Query Frame = 1
Query: 139 SSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLKYDWSEFWFWNPTEKLWLLPKSNIVSQFKLQPYSKINFVRRFNVLNIQLPDLQIRQLLLDFSKTVFQTNQIICKQFGIRHHEELSLQWKELKK-LDSNTPVPXXXXXXXXXXXXXXXXXXXXXXXXTLTSGLNTTGHRKRFTKPIYLTRNSQNDLEEPSPFNLVSPVSFFSI----FDDLSLNETDLSYYESFENSKLTNSPKKS---------FSEALKQQDIVIYKT----------YKDRANSPFHWMISELTLMEQAVGDYNNVLLRLRYKYHNYYWFNEKYDEIRINQIFHQSYWSMISGETDCSADETYLLAGILHHI---NKLSTNDTN---SETANLSPNDL-DKEIDSMLDRLHFDLIGKSCNEDE--MEHIEIAGNIELIKYPRNILSLYKKHSAVLSNEGINIIKTTNVSSKIPIKGNEIRLNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEMKSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQ-KVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSELQIIGIGYDRLILADIETGMVTNLVEMNKLISWKTNWELNNTLLMFSETFWKINFKN-SWECQIFHEYLGGYLFILMRNSEKFSDLNETIFRSLTG 2244
S+ ++I I ++ +RV I V + + K DWS+ W P + +WL + Q+ +Q SK+ ++ N L + LP + + ++FS +F ICK+FGIR EELSLQ +K+ L SN + T K F ++S +L P P +SP S ++ F L+ N LS +F S + P+ FSE +K +++ K R NS W+ S +LMEQ + L R+K+H +Y N KYD +RI+Q+F Q+ W +IS D + DE + + ++ST D N T N+ N++ + E+D M+ L +G D ++ + G++ + + + + K+ VL + +N + + ++ PI NEI ++ + + N + T+ + E K +F N+ ++ W ALRL+++ T F+ E + + ++ +++P + K + +L D + K KSK+ L+ ++ + LS ++AK YI+ W L N G Y+ V + ++ +IIGI ++R+++ + +G V + + SW NW+ +L F T K+ FK S C+ E++GGY+F+ RN +K +LN +F LTG
Sbjct: 10 GSWELTISITDIQNEVKVRVRGDVHIGGVMHKAVENLQRKQDWSDHMLWWPDKNIWLSHTRTTLDQYGVQSNSKLELIKVHNDLIVMLPSMHQVTVPVNFSADIFSVVIRICKEFGIRFPEELSLQIPLVKEDLKSNHTL--------------------------------TMMKSKIFAIQSSENKSSPKELPTPEP---LSPTSNYNTLKYPFGTLNHNTGTLSPMSTFNKSLSSQIPQSCNSLVIEGPEFSECMKMPAKSVFENNMLFQPKNLIQKARLNST--WLDSSRSLMEQGINADFKKPLYFRFKFHLFYDLNTKYDAVRIHQLFEQAKWDLISSSLDVTEDEMVVFVALQLQAELQTEISTEDQNMTVKPTDNVDANNVTEDEVDLMISELEEMCLGDQSKVDGQLVQEPRLEGSLRVYRTNKLGMKSQKRLWCVLQKQKLNFYVSKDELNQ-PI--NEILVS----------SCQMKAEVNVSANKFFIKITTSNREEFKFQFDNKDDYSNWMAALRLVARRKTLTNKVLFQKEIENIMEVLRLQTPAPQAVLTKEDLNNRLKDLNDYMPEKLIKKAKSKDYLRSRIGESHANVRLLSVLDAKHKYIQAWQRLENFGITYVIVKFDTCNKEEIIGIAFNRIMIINPNSGDVNGTHYFSDMRSWNINWDAEKVILDFKAT--KLVFKPLSTNCKTVIEFIGGYVFLNQRNPDKNQELNVKLFHKLTG 694
BLAST of PH domain-containing protein vs. Planmine SMEST
Match: SMESG000005290.1 (SMESG000005290.1) HSP 1 Score: 55.0694 bits (131), Expect = 1.967e-7 Identity = 55/220 (25.00%), Postives = 105/220 (47.73%), Query Frame = 1
Query: 1546 TSKSFERVKIRFYNQQEFIKWATALRLLSKSIDFTLLSNFKYEYQMVTNIVEM----KSPQFNLKMLKTNKEVDSVNLVDIIGSIHNKPFKSKEILQKVLYFAKSFSHLSKIEAKIAYIKCWLTLNNSGFHYMTVHVNQNSE---LQIIGIGYDRLILADIETGMVTNLV-EMNKLISWKTNWELNNTLLMFSETFWKINFKNSWECQ--IFHEYLGGYL 2175
+K +++++F+N ++F ++ S +L F E ++ +VE+ P++N+ + V LV+++G K +S + L+ +L + + F LS+ ++KI YI+ L +HY V +++ E L ++ + + I+ D +T LV L SWK N ELN L F F I+F + +C FHE++ ++
Sbjct: 463 CNKRLLKIEMKFFNDEDFFSLYSSAVAHSNFWWPSLKQIFDCE-RVARKLVEIFRSSDEPEYNIF------NMPRVELVNLLGCRIGKKEQSGKYLKTILQYNQCFKTLSRRKSKIQYIRFCLNFPRFNYHYFFVKIHEPPEEMGLTVVAVNEEMFIVFDPNYYSITRLVLPWAVLKSWKFNTELNQLDLYFKNLF--ISF-TTQDCSAICFHEFISTFI 672 The following BLAST results are available for this feature:
BLAST of PH domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of PH domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of PH domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of PH domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of PH domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of PH domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of PH domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of PH domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of PH domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of PH domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of PH domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of PH domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of PH domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of PH domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001904 ID=SMED30001904|Name=PH domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2388bpback to top protein sequence of SMED30001904-orf-1 >SMED30001904-orf-1 ID=SMED30001904-orf-1|Name=SMED30001904-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=718bp MSIDSLKSNRISSFVISIFIKELNTTHNIRVDPTATISKVATDLINKIHLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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