Cysteine rich with EGF like domains 2

Overview


Name	Cysteine rich with EGF like domains 2
Smed ID	SMED30001901
Length (bp)	5832

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cysteine rich with EGF like domains 2 (SMED30001901) t-SNE clustered cells

Violin plots show distribution of expression levels for Cysteine rich with EGF like domains 2 (SMED30001901) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cysteine rich with EGF like domains 2 (SMED30001901) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cysteine rich with EGF like domains 2 (SMED30001901) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001901

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30001901	SMESG000077687.1	SmedASXL_000016	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
epidermis	SMED30001901	SMESG000077687.1	dd_Smed_v4_12047_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30001901	SMESG000077687.1	dd_Smed_v4_41535_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30001901	SMESG000077687.1	dd_Smed_v4_41535_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30001901	SMESG000077687.1	dd_Smed_v4_41535_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30001901	SMESG000077687.1	dd_Smed_v6_12047_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Match: HMCN1 (hemicentin 1 [Source:HGNC Symbol;Acc:HGNC:19194])

HSP 1 Score: 55.0694 bits (131), Expect = 1.806e-6
Identity = 35/109 (32.11%), Postives = 50/109 (45.87%), Query Frame = 2

Query: 1100 DAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGF--QLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVC---DKTFSDGINCQTCDRCPEFQFDYN 1411
            D    G   C  N+IC+    +G       S +C+C RG+  Q     C+DINEC  E   + C  +   C NT GS+KC+C        DG +C   +R P +   Y+
Sbjct: 5274 DECKDGTHQCRYNQICENT--RG-------SYRCVCPRGYRSQGVGRPCMDINEC--EQVPKPCAHQ---CSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYS 5368

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Match: LTBP1 (latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714])

HSP 1 Score: 55.0694 bits (131), Expect = 1.844e-6
Identity = 33/90 (36.67%), Postives = 50/90 (55.56%), Query Frame = 2

Query: 1184 PVSQKCL-CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQFDYN-QCLDSKSTF 1438
            P S +C+ CT GF+ +NG C+D++ECL  N   +C   N  C N  GSY C C K ++   D  +C+  D C +     N QC +++ +F
Sbjct: 1017 PGSYQCVPCTEGFRGWNGQCLDVDECLEPN---VCA--NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSF 1101

HSP 2 Score: 53.1434 bits (126), Expect = 7.269e-6
Identity = 32/70 (45.71%), Postives = 39/70 (55.71%), Query Frame = 2

Query: 1190 SQKCLCTRGFQLY-NGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRC 1387
            S  C C  GFQL  N  C DINEC +     LCG + + C+NT GS+ CVC + FS   DG  C+  D C
Sbjct: 1183 SYDCTCPDGFQLDDNKTCQDINECEHPG---LCGPQGE-CLNTEGSFHCVCQQGFSISADGRTCEDIDEC 1248

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Match: HMCN2 (hemicentin 2 [Source:HGNC Symbol;Acc:HGNC:21293])

HSP 1 Score: 53.5286 bits (127), Expect = 5.486e-6
Identity = 34/111 (30.63%), Postives = 50/111 (45.05%), Query Frame = 2

Query: 1154 AWRQGRLGCDPVSQ--KCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCD---KTFSDGINCQTCDRCPEFQFDY---NQCLDSKSTF-CIDIRNP 1459
            AW   R G   +S   +  C  GF   NG C D++EC      R+  L    C NT GSY+C+C    +    G NCQ  + C E   +      C +++ ++ C+D   P
Sbjct: 4831 AWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDEC------RVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCP 4935

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Match: LTBP2 (latent transforming growth factor beta binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6715])

HSP 1 Score: 53.5286 bits (127), Expect = 5.549e-6
Identity = 29/70 (41.43%), Postives = 39/70 (55.71%), Query Frame = 2

Query: 1190 SQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF---SDGINCQTCDRC 1387
            S +CLC +GFQL NG  C D+NEC+ E     C    + C+N+ GS+ C+C   F     G +CQ  D C
Sbjct: 1157 SYQCLCPQGFQLANGTVCEDVNECMGEEH---CAPHGE-CLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC 1222

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Match: LTBP2 (latent transforming growth factor beta binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6715])

HSP 1 Score: 53.5286 bits (127), Expect = 5.574e-6
Identity = 29/70 (41.43%), Postives = 39/70 (55.71%), Query Frame = 2

Query: 1190 SQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF---SDGINCQTCDRC 1387
            S +CLC +GFQL NG  C D+NEC+ E     C    + C+N+ GS+ C+C   F     G +CQ  D C
Sbjct: 1157 SYQCLCPQGFQLANGTVCEDVNECMGEEH---CAPHGE-CLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC 1222

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Match: mec-1 (pep chromosome:WBcel235:V:6956537:6961338:1 gene:WBGene00003165.1 transcript:T07H8.4c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mec-1)

HSP 1 Score: 58.9214 bits (141), Expect = 4.385e-8
Identity = 41/121 (33.88%), Postives = 58/121 (47.93%), Query Frame = 2

Query: 1064 LKAIPINIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCL-----CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYN 1411
            L+ + + IF   +   SG+     N +CQ         CDP+   CL     C +GF+     CID+NEC N     +CG  N  C+N IGS++CVCD  FS   +C+        +FD N
Sbjct:  148 LELVQVRIF---NKTESGH----GNGLCQ--------DCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNG---AVCG-PNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVN 249

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Match: mec-1 (pep chromosome:WBcel235:V:6956537:6961061:1 gene:WBGene00003165.1 transcript:T07H8.4i.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mec-1)

HSP 1 Score: 58.151 bits (139), Expect = 6.418e-8
Identity = 41/121 (33.88%), Postives = 58/121 (47.93%), Query Frame = 2

Query: 1064 LKAIPINIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCL-----CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYN 1411
            L+ + + IF   +   SG+     N +CQ         CDP+   CL     C +GF+     CID+NEC N     +CG  N  C+N IGS++CVCD  FS   +C+        +FD N
Sbjct:  148 LELVQVRIF---NKTESGH----GNGLCQ--------DCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNG---AVCG-PNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVN 249

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Match: mec-1 (pep chromosome:WBcel235:V:6956542:6966422:1 gene:WBGene00003165.1 transcript:T07H8.4h.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mec-1)

HSP 1 Score: 57.7658 bits (138), Expect = 1.107e-7
Identity = 41/122 (33.61%), Postives = 61/122 (50.00%), Query Frame = 2

Query: 1064 LKAIPINIFSIDDAA-ASGYPMCDANEICQTAWRQGRLGCDPV-----SQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYN 1411
            L+ + + IF+  +++  SG+     N +CQ         CDP+       KC C +GF+     CID+NEC N     +CG  N  C+N IGS++CVCD  FS   +C+        +FD N
Sbjct:  148 LELVQVRIFNKTESSFQSGH----GNGLCQD--------CDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNG---AVCG-PNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVN 253

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Match: mec-1 (pep chromosome:WBcel235:V:6956537:6966422:1 gene:WBGene00003165.1 transcript:T07H8.4h.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mec-1)

HSP 1 Score: 57.7658 bits (138), Expect = 1.107e-7
Identity = 41/122 (33.61%), Postives = 61/122 (50.00%), Query Frame = 2

Query: 1064 LKAIPINIFSIDDAA-ASGYPMCDANEICQTAWRQGRLGCDPV-----SQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYN 1411
            L+ + + IF+  +++  SG+     N +CQ         CDP+       KC C +GF+     CID+NEC N     +CG  N  C+N IGS++CVCD  FS   +C+        +FD N
Sbjct:  148 LELVQVRIFNKTESSFQSGH----GNGLCQD--------CDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNG---AVCG-PNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVN 253

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Match: mec-1 (pep chromosome:WBcel235:V:6956542:6966422:1 gene:WBGene00003165.1 transcript:T07H8.4a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mec-1)

HSP 1 Score: 57.7658 bits (138), Expect = 1.107e-7
Identity = 41/122 (33.61%), Postives = 61/122 (50.00%), Query Frame = 2

Query: 1064 LKAIPINIFSIDDAA-ASGYPMCDANEICQTAWRQGRLGCDPV-----SQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYN 1411
            L+ + + IF+  +++  SG+     N +CQ         CDP+       KC C +GF+     CID+NEC N     +CG  N  C+N IGS++CVCD  FS   +C+        +FD N
Sbjct:  148 LELVQVRIFNKTESSFQSGH----GNGLCQD--------CDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNG---AVCG-PNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVN 253

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Zebrafish
Match: hmcn1 (hemicentin 1 [Source:ZFIN;Acc:ZDB-GENE-041014-322])

HSP 1 Score: 58.5362 bits (140), Expect = 1.233e-7
Identity = 36/101 (35.64%), Postives = 53/101 (52.48%), Query Frame = 2

Query: 1202 LCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF---SDGINCQTCDRCPE--FQFDYNQ-CLDSKSTF-CIDIRNPLLPDKSDD 1483
            +C  GF+  NG C+DINEC   +T   C  +   CMNT GS++C+C   +   ++G  CQ  D C E   Q   N+ C + + ++ CID   P  P+   D
Sbjct: 5397 ICPHGFKTKNGHCLDINECEQRDT---CQHE---CMNTPGSHRCLCPSGYRLMTNGKTCQDIDECLEQNIQCGANRMCFNMRGSYQCID--TPCPPNYQRD 5489

HSP 2 Score: 53.5286 bits (127), Expect = 3.812e-6
Identity = 42/126 (33.33%), Postives = 57/126 (45.24%), Query Frame = 2

Query: 1109 ASGYPMCDANEICQTAWRQGRLGCDPVSQKCL---------CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCV--CDKTFSDGIN--CQTCDRCPE--FQFDYNQ-CLDSKSTF 1438
            A G    D NE CQ +        +P  Q CL         C  G+QL N  CIDINEC     +R+C   ++ C NT G Y C+  C    + G N  C   D C +   Q  YNQ C +++ ++
Sbjct: 5160 ADGLSCSDVNE-CQES--------NPCHQHCLNTIGSFRCACEPGYQLRNRRCIDINEC----KQRVC-RSDQQCKNTRGGYTCIDLCPTGMTKGGNGTCIDIDECHDGTHQCRYNQICENTRGSY 5271

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Query: 1202 LCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF---SDGINCQTCDRCPE--FQFDYNQ-CLDSKSTF-CIDIRNPLLPDKSDD 1483
            +C  GF+  NG C+DINEC   +T   C  +   CMNT GS++C+C   +   ++G  CQ  D C E   Q   N+ C + + ++ CID   P  P+   D
Sbjct: 5399 ICPHGFKTKNGHCLDINECEQRDT---CQHE---CMNTPGSHRCLCPSGYRLMTNGKTCQDIDECLEQNIQCGANRMCFNMRGSYQCID--TPCPPNYQRD 5491

HSP 2 Score: 53.5286 bits (127), Expect = 3.812e-6
Identity = 42/126 (33.33%), Postives = 57/126 (45.24%), Query Frame = 2

Query: 1109 ASGYPMCDANEICQTAWRQGRLGCDPVSQKCL---------CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCV--CDKTFSDGIN--CQTCDRCPE--FQFDYNQ-CLDSKSTF 1438
            A G    D NE CQ +        +P  Q CL         C  G+QL N  CIDINEC     +R+C   ++ C NT G Y C+  C    + G N  C   D C +   Q  YNQ C +++ ++
Sbjct: 5162 ADGLSCSDVNE-CQES--------NPCHQHCLNTIGSFRCACEPGYQLRNRRCIDINEC----KQRVC-RSDQQCKNTRGGYTCIDLCPTGMTKGGNGTCIDIDECHDGTHQCRYNQICENTRGSY 5273

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Match: ENSXETT00000024069.1 (hemicentin 2 [Source:NCBI gene;Acc:100490941])

HSP 1 Score: 55.8398 bits (133), Expect = 1.060e-6
Identity = 33/95 (34.74%), Postives = 45/95 (47.37%), Query Frame = 2

Query: 1109 ASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVC---DKTFSDGINCQTCDR 1384
            A G    D +E  Q++  Q R      S +C C  G+QL    C+DINECL     + C  +   C N  GSYKC+C    +   DG +C   +R
Sbjct: 3763 AEGTACEDVDECAQSSPCQQRCLNTIGSYRCACDPGYQLRGTICVDINECL--QVPKPCAFE---CQNIAGSYKCLCPPGKQLLGDGRSCAGLER 3852

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Match: nid2 (nidogen 2 [Source:NCBI gene;Acc:100036716])

HSP 1 Score: 55.0694 bits (131), Expect = 1.813e-6
Identity = 36/99 (36.36%), Postives = 46/99 (46.46%), Query Frame = 2

Query: 1121 PMCDANEICQTAWRQGRLGCDPVSQ---KCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQ 1399
            P  D   +C T     R  C P S     C+C  G+Q     C D+NEC  E     CG +N +C+N  GSY+C C   F+   DG NC   D C E +
Sbjct:  691 PCYDGTHLCDT-----RAKCQPGSGLEYSCVCASGYQGDGRDCTDVNEC--EVGFTRCG-QNTVCVNLQGSYRCECASGFTLSGDGHNCIYVDECTEHR 781

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Match: CRELD2 (cysteine rich with EGF-like domains 2 [Source:NCBI gene;Acc:100497878])

HSP 1 Score: 52.7582 bits (125), Expect = 3.725e-6
Identity = 30/83 (36.14%), Postives = 46/83 (55.42%), Query Frame = 2

Query: 1145 CQTAWRQ--GR-LGCDPVSQKCL---------CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD 1357
            C+  W +  G+ +GCD     C          C  G+ L +G CID++EC  + +E +C  +N+ C+NT GSYKC+C + F D
Sbjct:  215 CKNGWLKDGGKCVGCDKSCISCSGEGPENCKDCATGYVLLDGICIDVDEC--DASENICVRENETCLNTAGSYKCICSEGFED 295

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Match: CRELD2 (cysteine rich with EGF-like domains 2 [Source:NCBI gene;Acc:100497878])

HSP 1 Score: 52.373 bits (124), Expect = 5.357e-6
Identity = 23/51 (45.10%), Postives = 35/51 (68.63%), Query Frame = 2

Query: 1205 CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD 1357
            C  G+ L +G CID++EC  + +E +C  +N+ C+NT GSYKC+C + F D
Sbjct:  269 CATGYVLLDGICIDVDEC--DASENICVRENETCLNTAGSYKCICSEGFED 317

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Match: CRELD2 (cysteine rich with EGF-like domains 2 [Source:NCBI gene;Acc:100497878])

HSP 1 Score: 51.9878 bits (123), Expect = 5.515e-6
Identity = 23/51 (45.10%), Postives = 35/51 (68.63%), Query Frame = 2

Query: 1205 CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD 1357
            C  G+ L +G CID++EC  + +E +C  +N+ C+NT GSYKC+C + F D
Sbjct:  228 CATGYVLLDGICIDVDEC--DASENICVRENETCLNTAGSYKCICSEGFED 276

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Match: Hmcn1 (hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047])

HSP 1 Score: 60.8474 bits (146), Expect = 2.864e-8
Identity = 51/165 (30.91%), Postives = 71/165 (43.03%), Query Frame = 2

Query: 1100 DAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGF--QLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQF---DYNQCLDSKSTF-CIDI-------RNPLL--------PDKSDDHLKEDRKSYKLIS 1522
            D    G   C  N+IC+    +G       S +C C RG+  Q     CIDI+EC N +T   C  +   C NTIGSY+CVC   +    +G  CQ  D C E          C + + ++ CID        R+P+L        P+  +  L      YKL+S
Sbjct: 5273 DECKDGTHQCRYNQICENT--RG-------SYRCACPRGYRSQGVGRPCIDIDECQNRDT---CQHE---CKNTIGSYQCVCPPGYRLMLNGKTCQDVDECLEQNVRCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVLGFCLKNCPPNDLECTLSPYALEYKLVS 5422

HSP 2 Score: 52.7582 bits (125), Expect = 7.033e-6
Identity = 43/133 (32.33%), Postives = 59/133 (44.36%), Query Frame = 2

Query: 1199 CLCTRGFQLYNGA--CIDINEC-LNENTERLCGLKNKICMNTIGSYKCV--CDKTF---SDGINCQTCDRCPEFQFDYNQCLDSKSTF--------------CIDI----RNPLLPDKSDDHLKEDRKSYKLI 1519
            C C +G  +      C DI+EC L  +T R      + C NTIGSY+CV  C   F   SDG++CQ  + C E    + +C +   +F              CID+    +N   PD+   H K  R  YK I
Sbjct: 5129 CSCPKGLTIAADGRTCQDIDECALGGHTCR----AGQDCDNTIGSYRCVVHCGTGFRRTSDGLSCQDINECQESSPCHQRCFNVIGSFHCGCEAGYQLKGRKCIDVNECRQNVCRPDQ---HCKNTRGGYKCI 5254

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Match: Ltbp2 (latent transforming growth factor beta binding protein 2 [Source:MGI Symbol;Acc:MGI:99502])

HSP 1 Score: 56.9954 bits (136), Expect = 3.656e-7
Identity = 34/90 (37.78%), Postives = 47/90 (52.22%), Query Frame = 2

Query: 1130 DANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD---GINCQTCDRC 1387
            D  E  Q++ R G       S +CLC +GFQL NG  C D+NEC+ E     C    + C+N++GS+ C+C   F+    G  CQ  D C
Sbjct: 1082 DECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVNGTMCEDVNECVGEEH---CAPHGE-CLNSLGSFFCLCAPGFASAEGGTRCQDVDEC 1167

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Match: Ltbp2 (latent transforming growth factor beta binding protein 2 [Source:MGI Symbol;Acc:MGI:99502])

HSP 1 Score: 56.9954 bits (136), Expect = 3.662e-7
Identity = 34/90 (37.78%), Postives = 47/90 (52.22%), Query Frame = 2

Query: 1130 DANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD---GINCQTCDRC 1387
            D  E  Q++ R G       S +CLC +GFQL NG  C D+NEC+ E     C    + C+N++GS+ C+C   F+    G  CQ  D C
Sbjct: 1102 DECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVNGTMCEDVNECVGEEH---CAPHGE-CLNSLGSFFCLCAPGFASAEGGTRCQDVDEC 1187

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Match: Ltbp2 (latent transforming growth factor beta binding protein 2 [Source:MGI Symbol;Acc:MGI:99502])

HSP 1 Score: 56.9954 bits (136), Expect = 3.826e-7
Identity = 34/90 (37.78%), Postives = 47/90 (52.22%), Query Frame = 2

Query: 1130 DANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD---GINCQTCDRC 1387
            D  E  Q++ R G       S +CLC +GFQL NG  C D+NEC+ E     C    + C+N++GS+ C+C   F+    G  CQ  D C
Sbjct: 1125 DECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVNGTMCEDVNECVGEEH---CAPHGE-CLNSLGSFFCLCAPGFASAEGGTRCQDVDEC 1210

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Match: Ltbp1 (latent transforming growth factor beta binding protein 1 [Source:MGI Symbol;Acc:MGI:109151])

HSP 1 Score: 55.4546 bits (132), Expect = 9.661e-7
Identity = 33/90 (36.67%), Postives = 49/90 (54.44%), Query Frame = 2

Query: 1184 PVSQKCL-CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQFDYN-QCLDSKSTF 1438
            P S +C+ CT GF+ +NG C+D++ECL     ++C   N  C N  GSY C C + +S   D  +CQ  D C +     N QC ++  +F
Sbjct: 1009 PGSYQCVPCTEGFRGWNGQCLDVDECLQ---PKVC--TNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSF 1093

HSP 2 Score: 54.299 bits (129), Expect = 2.223e-6
Identity = 32/70 (45.71%), Postives = 38/70 (54.29%), Query Frame = 2

Query: 1190 SQKCLCTRGFQLY-NGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRC 1387
            S  C C  GFQL  N  C DINEC       LCG   + C+NT GS+ CVC++ FS   DG  C+  D C
Sbjct: 1175 SYDCTCPDGFQLNDNKGCQDINECAQPG---LCGSHGE-CLNTQGSFHCVCEQGFSISADGRTCEDIDEC 1240

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Match: sp|Q00918|LTBP1_RAT (Latent-transforming growth factor beta-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Ltbp1 PE=1 SV=1)

HSP 1 Score: 56.225 bits (134), Expect = 3.717e-6
Identity = 34/90 (37.78%), Postives = 49/90 (54.44%), Query Frame = 2

Query: 1184 PVSQKCL-CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQFDYN-QCLDSKSTF 1438
            P S +C+ CT GF+ +NG C+D++ECL     ++C   N  C N  GSY C C K +S   D  +CQ  D C +     N QC ++  +F
Sbjct: 1009 PGSYQCVPCTEGFRGWNGQCLDVDECLQ---PKVC--TNGSCTNLEGSYMCSCHKGYSPTPDHRHCQDIDECQQGNLCMNGQCKNTDGSF 1093

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Match: sp|O08999|LTBP2_MOUSE (Latent-transforming growth factor beta-binding protein 2 OS=Mus musculus OX=10090 GN=Ltbp2 PE=1 SV=2)

HSP 1 Score: 56.225 bits (134), Expect = 3.910e-6
Identity = 34/90 (37.78%), Postives = 47/90 (52.22%), Query Frame = 2

Query: 1130 DANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGA-CIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD---GINCQTCDRC 1387
            D  E  Q++ R G       S +CLC +GFQL NG  C D+NEC+ E     C    + C+N++GS+ C+C   F+    G  CQ  D C
Sbjct: 1128 DECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVNGTMCEDVNECVGEEH---CAPHGE-CLNSLGSFFCLCAPGFASAEGGTRCQDVDEC 1213

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Match: sp|B5DFC9|NID2_RAT (Nidogen-2 OS=Rattus norvegicus OX=10116 GN=Nid2 PE=2 SV=1)

HSP 1 Score: 55.8398 bits (133), Expect = 5.290e-6
Identity = 39/122 (31.97%), Postives = 51/122 (41.80%), Query Frame = 2

Query: 1079 INIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDP---VSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYNQCLDSKST 1435
            I    +D A  +  P  D +  C T  R     C P   V   C CT GFQ    +C+D+NEC        CG  N +C+N +GSY+C C   +    +  TC          N CLD   T
Sbjct:  764 IGPVEVDSAPTAVNPCYDGSHTCDTTAR-----CHPGTGVDYTCECTPGFQGDGRSCVDVNECATGF--HRCG-PNSVCVNLVGSYRCECRSGYEFADDRHTCVL---IAPPPNPCLDGSHT 874

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Match: sp|O88322|NID2_MOUSE (Nidogen-2 OS=Mus musculus OX=10090 GN=Nid2 PE=1 SV=2)

HSP 1 Score: 55.4546 bits (132), Expect = 6.992e-6
Identity = 39/122 (31.97%), Postives = 50/122 (40.98%), Query Frame = 2

Query: 1079 INIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDP---VSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYNQCLDSKST 1435
            I    +D A     P  D +  C T  R     C P   V   C CT GFQ    +C+D+NEC        CG  N +C+N +GSY+C C   +    +  TC          N CLD   T
Sbjct:  771 IGPVEVDSAPVGVNPCYDGSHTCDTTAR-----CHPGTGVDYTCECTPGFQGDGRSCVDVNECATGF--HRCG-PNSVCVNLVGSYRCECRSGYEFADDQHTCIL---IAPPPNPCLDGSHT 881

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Match: sp|Q8CG19|LTBP1_MOUSE (Latent-transforming growth factor beta-binding protein 1 OS=Mus musculus OX=10090 GN=Ltbp1 PE=1 SV=2)

HSP 1 Score: 55.4546 bits (132), Expect = 7.476e-6
Identity = 33/90 (36.67%), Postives = 49/90 (54.44%), Query Frame = 2

Query: 1184 PVSQKCL-CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPEFQFDYN-QCLDSKSTF 1438
            P S +C+ CT GF+ +NG C+D++ECL     ++C   N  C N  GSY C C + +S   D  +CQ  D C +     N QC ++  +F
Sbjct: 1009 PGSYQCVPCTEGFRGWNGQCLDVDECLQ---PKVC--TNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSF 1093

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Match: A0A2R2ML22 (uncharacterized protein LOC106172251 isoform X3 OS=Lingula unguis OX=7574 GN=LOC106172251 PE=4 SV=1)

HSP 1 Score: 217.238 bits (552), Expect = 1.388e-52
Identity = 179/729 (24.55%), Postives = 313/729 (42.94%), Query Frame = 2

Query: 1079 INIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF-SDGINCQTCD-RCPEFQFDYNQCLDS------------KSTF------------CIDIRNPLLPDKSDDHL---KEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSN----KASLLPFERNGFYCTQNSEFVNNIFNHQI-DEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNLSCMAFYTSKCYDGKLDKSLHA------ENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKP---IVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKY-LQFQNWQPFYFNSENWYN-FSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELL-NKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPT-VWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQII 3124
            I++F +D AAA+    C   ++C        +GC+  +QKC+C RG+ L  G C D++EC +    R CG +N  C+NT G Y+C+C + F S G  C+ C   CP   +  + C D+            K+ +            C+ + NPL    SD  +     +   +   +  N+F EDLL+  SL  ++  + N Q S F++ R+SGL + I ++NI + P F D +H  DN+ + KS Q       K    N++   CR P+P +Y +++  YR R +    ++C +      K  CP  F +G+ +Y+R++N  C       K  L     N   CT  +  +  +F+  + D+ +       C      C+ CL S   V                  N SC A   + C + K  K ++         IC  GDT++FTL P F+  +  F+CHL+ +        + + +HI + D P  T +    I    + +  +G   I F+ ++       + EM + G      +     L++ K   +F KG  +V+   +S +       +PF  +S +W N   C  +    +  Q +Y      V     N D        +KY +       ++ V +  N+S++  ++   ++G        FD  F   + +   T  W +   G ++  P ++ + + D+T    LF+ D ++
Sbjct:  544 IHVFDLDSAAATNRSTCLPAQVCPEFGPVHLIGCNAATQKCVCQRGYSLLQGTCQDLDEC-STGIHR-CG-RNSRCINTQGGYRCMCGEGFYSLGGTCRACSGSCPPGFYQSSPCSDTQDRKCAVCVHCTKTGYEVRPCGRGMNRKCVSVSNPLGTPPSDGRVFVEANNTGDFSYQTPRNMFVEDLLKTHSLQSTVYATYNNQYSDFLWQRESGLKINIYVDNIQILPTFTDTSHLSDNAYMYKSPQPGE----KEKFANIVTKFCRHPVPDFYNLSLEIYRSRTSAVTAVVCDSSN--PDKIRCPQQFKNGETFYYRSVNKDCQRRGIALKDKLAETNSNSILCTVETPLLTKLFSKTLKDDTLETFPHWQCSPKEMTCQACLSSRACVSSGL--------------NQSCCA---TDCLNTKECKFVYQPLCANKSVICSTGDTVQFTLHPMFNNISSQFMCHLRYVPPPMYLYRVRYRMHIDNFDTPFSTEQEIYNITASNIHEHNNGSNHIGFLDVSHNTKFQLKDEMMMVGDMNAAARDYQLSLHQFKDVGEFDKGKFQVFSFSDSIFTTSLTPERPFQVSSVSWNNQEGCWRNISTLHKKQKMYKKHGVTVNYTKMNTD------GTYKYILSPKIYGPEISVSIPGNRSVLYHYMKHVRAGI------RFDDSFKTHLELNTTTKKWNMSISGYLTGCPAYVAIIVNDLTEMVQLFNLDTLV 1234

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Match: A0A2R2MLG8 (uncharacterized protein LOC106172251 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106172251 PE=4 SV=1)

HSP 1 Score: 215.698 bits (548), Expect = 4.219e-52
Identity = 178/726 (24.52%), Postives = 310/726 (42.70%), Query Frame = 2

Query: 1079 INIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF-SDGINCQTC-DRCPEFQFDYNQCLDS------------KSTF------------CIDIRNPLLPDKSDDHL---KEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSN----KASLLPFERNGFYCTQNSEFVNNIFNHQI-DEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNLSCMA---FYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKP---IVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKY-LQFQNWQPFYFNSENWYN-FSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELL-NKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPT-VWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQII 3124
            I++F +D AAA+    C   ++C        +GC+  +QKC+C RG+ L  G C D++EC +    R CG +N  C+NT G Y+C+C + F S G  C+ C   CP   +  + C D+            K+ +            C+ + NPL    SD  +     +   +   +  N+F EDLL+  SL  ++  + N Q S F++ R+SGL + I ++NI + P F D +H  DN+ + KS Q       K    N++   CR P+P +Y +++  YR R +    ++C +      K  CP  F +G+ +Y+R++N  C       K  L     N   CT  +  +  +F+  + D+ +       C      C+ CL S   V                  N SC A     T +C         +   IC  GDT++FTL P F+  +  F+CHL+ +        + + +HI + D P  T +    I    + +  +G   I F+ ++       + EM + G      +     L++ K   +F KG  +V+   +S +       +PF  +S +W N   C  +    +  Q +Y      V     N D        +KY +       ++ V +  N+S++  ++   ++G        FD  F   + +   T  W +   G ++  P ++ + + D+T    LF+ D ++
Sbjct:  966 IHVFDLDSAAATNRSTCLPAQVCPEFGPVHLIGCNAATQKCVCQRGYSLLQGTCQDLDEC-STGIHR-CG-RNSRCINTQGGYRCMCGEGFYSLGGTCRACSGSCPPGFYQSSPCSDTQDRKCAVCVHCTKTGYEVRPCGRGMNRKCVSVSNPLGTPPSDGRVFVEANNTGDFSYQTPRNMFVEDLLKTHSLQSTVYATYNNQYSDFLWQRESGLKINIYVDNIQILPTFTDTSHLSDNAYMYKSPQPGE----KEKFANIVTKFCRHPVPDFYNLSLEIYRSRTSAVTAVVCDSSN--PDKIRCPQQFKNGETFYYRSVNKDCQRRGIALKDKLAETNSNSILCTVETPLLTKLFSKTLKDDTLETFPHWQCSPKEMTCQACLSSRACVSSGL--------------NQSCCATDCLNTKECKFVYQPLCANKSVICSTGDTVQFTLHPMFNNISSQFMCHLRYVPPPMYLYRVRYRMHIDNFDTPFSTEQEIYNITASNIHEHNNGSNHIGFLDVSHNTKFQLKDEMMMVGDMNAAARDYQLSLHQFKDVGEFDKGKFQVFSFSDSIFTTSLTPERPFQVSSVSWNNQEGCWRNISTLHKKQKMYKKHGVTVNYTKMNTD------GTYKYILSPKIYGPEISVSIPGNRSVLYHYMKHVRAGI------RFDDSFKTHLELNTTTKKWNMSISGYLTGCPAYVAIIVNDLTEMVQLFNLDTLV 1656

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Match: A0A2R2ML12 (uncharacterized protein LOC106172251 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106172251 PE=4 SV=1)

HSP 1 Score: 215.698 bits (548), Expect = 4.291e-52
Identity = 178/726 (24.52%), Postives = 310/726 (42.70%), Query Frame = 2

Query: 1079 INIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF-SDGINCQTC-DRCPEFQFDYNQCLDS------------KSTF------------CIDIRNPLLPDKSDDHL---KEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSN----KASLLPFERNGFYCTQNSEFVNNIFNHQI-DEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNLSCMA---FYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKP---IVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKY-LQFQNWQPFYFNSENWYN-FSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELL-NKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPT-VWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQII 3124
            I++F +D AAA+    C   ++C        +GC+  +QKC+C RG+ L  G C D++EC +    R CG +N  C+NT G Y+C+C + F S G  C+ C   CP   +  + C D+            K+ +            C+ + NPL    SD  +     +   +   +  N+F EDLL+  SL  ++  + N Q S F++ R+SGL + I ++NI + P F D +H  DN+ + KS Q       K    N++   CR P+P +Y +++  YR R +    ++C +      K  CP  F +G+ +Y+R++N  C       K  L     N   CT  +  +  +F+  + D+ +       C      C+ CL S   V                  N SC A     T +C         +   IC  GDT++FTL P F+  +  F+CHL+ +        + + +HI + D P  T +    I    + +  +G   I F+ ++       + EM + G      +     L++ K   +F KG  +V+   +S +       +PF  +S +W N   C  +    +  Q +Y      V     N D        +KY +       ++ V +  N+S++  ++   ++G        FD  F   + +   T  W +   G ++  P ++ + + D+T    LF+ D ++
Sbjct:  966 IHVFDLDSAAATNRSTCLPAQVCPEFGPVHLIGCNAATQKCVCQRGYSLLQGTCQDLDEC-STGIHR-CG-RNSRCINTQGGYRCMCGEGFYSLGGTCRACSGSCPPGFYQSSPCSDTQDRKCAVCVHCTKTGYEVRPCGRGMNRKCVSVSNPLGTPPSDGRVFVEANNTGDFSYQTPRNMFVEDLLKTHSLQSTVYATYNNQYSDFLWQRESGLKINIYVDNIQILPTFTDTSHLSDNAYMYKSPQPGE----KEKFANIVTKFCRHPVPDFYNLSLEIYRSRTSAVTAVVCDSSN--PDKIRCPQQFKNGETFYYRSVNKDCQRRGIALKDKLAETNSNSILCTVETPLLTKLFSKTLKDDTLETFPHWQCSPKEMTCQACLSSRACVSSGL--------------NQSCCATDCLNTKECKFVYQPLCANKSVICSTGDTVQFTLHPMFNNISSQFMCHLRYVPPPMYLYRVRYRMHIDNFDTPFSTEQEIYNITASNIHEHNNGSNHIGFLDVSHNTKFQLKDEMMMVGDMNAAARDYQLSLHQFKDVGEFDKGKFQVFSFSDSIFTTSLTPERPFQVSSVSWNNQEGCWRNISTLHKKQKMYKKHGVTVNYTKMNTD------GTYKYILSPKIYGPEISVSIPGNRSVLYHYMKHVRAGI------RFDDSFKTHLELNTTTKKWNMSISGYLTGCPAYVAIIVNDLTEMVQLFNLDTLV 1656

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Match: A0A4E0RZ73 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_001335 PE=4 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 3.067e-47
Identity = 136/485 (28.04%), Postives = 219/485 (45.15%), Query Frame = 2

Query: 1517 ISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSG-DNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICAN-QKYPGSKEFCPADFFDGQIYYFRTLNNRCSSN---------KASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXX--------------------------YRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIM---------------LDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGT--------------------------KSISYRL--YKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSC 2731
            +   ++F ED  Q++S+     V +   N +F     +G+ V + + +I + P ++DV H G DN I+L +S+ S+ +H + PL  +L++ CR+P+PK+YY+TM+ Y  R+TTA + IC    +    +  CP     G +YY R++N +C+ N         KAS LP +RN FYCT NSE V  +FN  I E+ S  + + CD   + C+TCLR S               E                             Y N SC  +Y   C    +++    + ICL+G TLKFTL P+FD  N S+LCHL+   +    + I      IDN    W ++P+   +                L +F+G       ++N       E+   L   Q HG                           +S++ ++  +++K   +F     ++ KH++ KY+  Q  +PF +N+E W N SC
Sbjct:  226 VQGRHLFKEDFEQVKSMQERRIVRNKGDNMTFDLQYTTGINVHVAIMDIRLLPEYQDVEHEGSDNGIVLDTSRRSNMHHWRAPLQALLKSKCRYPIPKHYYLTMHPYSDRHTTAKRQICRRADEVHSRRRLCPKGLPPGSVYYQRSINGQCTQNLISATLITDKASFLPPQRNSFYCTTNSELVTELFNEHITERQSYLKDAHCDTQRRICQTCLRRSCWTESRRQTDGNDLIEDLTQSWDWMHDEVISAVKERYQKCCGVSCYSNPSCQEYYNPACQRYTINQP-EMDEICLQGQTLKFTLNPEFDLNNGSYLCHLRY--NPPSHLYIIRTWLTIDNR---WQTQPVRMTVTAADSTHRHRAQSNSALPEFTG-------TMNHVQRHAQEEHNLLMARQNHGQLWLWNHAVKIEHHSKMPIWSEGIVQGESVTDQMTWHRLKTPDEFGLLKPELQKHRDEKYVVMQVTRPFLYNTETWGNQSC 697

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Match: A0A267GV26 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002472g1 PE=4 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 1.936e-44
Identity = 181/773 (23.42%), Postives = 334/773 (43.21%), Query Frame = 2

Query: 1061 YLKAIP-INIFSIDD-----AAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLY--NGACIDINEC-LNENTERLCGLKNKICMNTIGSYKCVCDKT-FSDGIN-------------------------CQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKE---------DRKSYKLISSENVFSEDLLQL-ESLNISIGVSSNKQNSSFIFNRKSG-LVVRINLNNISMNPMFEDV----------THSGDNSIILK--------SSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQK-YPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFER--NGFYCTQNSEFVNNIFNHQIDEKISVSQ-KSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENES----FLCHLKKIDDSKPRMTISFNLHII-DNDKPLWTSKPIVQEIMLDKFSGHK--FIDFISLNWTN--FIDSEKEMYLKG--FQEHGTKSISYRLYKMKKKKDFTKGPMKVYKH-QNSKYLQ--FQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELLNKSIIRSFVCSEK-SGKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQIIHK 3130
            +++ +P + +F   D      A +G   C   + C+ A  Q RLGC P S +C C RGF+ Y   GAC+DI+EC L  +   +C  ++ +C N +G Y C C +  + +GI                          CQ C+ CP   F+  QCL   +  C+    PL   + D+ L++         + +  K+  S  V +E +  L       + ++SN  + SFI+   +  + V +++  +++ P+++D             + DN+ I K        +S G+  +  K  L +V   +CR P+P +Y + +    +      +I CAN+K    + + CPAD+   + YY R LN+ CS         E   N FYC Q +E +  +FN    E+++       C     KC  C ++  +          SCC+ +C+ +L+C +FY   C        +  E +C +GD  +F L P FD  + +    FLCH+   +      +I +N+ +  D D   W    + Q +     S H+   +DF  L  T+   ID  ++  + G  +Q+      +  +++++   +   G ++V      S Y     Q  +PF  +S NW +  C +++    P   +Y    Q +     + +        F YT+ S +   ++++    +S++R + C +  S +L    G         ++     +W I   G+V+  P ++ +++ DI  + +L  Q+ +I +
Sbjct:  387 HVRPVPALKVFDTPDITESVTADAGGDACKKRDRCRIALGQNRLGCHPSSAECACVRGFRFYAPTGACVDIDECSLGSD---ICS-RDAVCTNLVGFYSCACREGYYGNGIRCTKCRQSCPPGQYMASQCTRTRDAVCQACNHCPPGYFEARQCLRRVNRKCLHAARPL--KQVDNRLRDEDFIPVPTSESQRIKVQLSRGVLAEPVDGLRSRRQRRVRIASNGVDKSFIWEGANPEIAVHVSITGVNLVPVYKDGNKTMGLGGRQVDASDNAFIAKYLAKRDEHTSSGAGRWSAK--LRDVHAKYCRQPIPDHYVLQLTRRSNILNRVQRISCANRKNLSPTSDRCPADYGPDEQYYVRRLNSPCSRQDQIGFYMEPNLNKFYCGQTTELLARVFNMTNFEELTPPIFADDCAHAAAKCLAC-QNQKEDKCQQPGLGVSCCKLECFSSLACSSFYRETC--------MKVEPVCARGDVDRFVLTPTFDGFSHANRTYFLCHV-TYEPPDQLYSIGYNVSLAGDGDAAEWRGDTLWQRVPSANASFHRRGSVDFGPLRVTHDAEIDLPQDYIVHGSLWQQRQRTMANLTVHQLRSDTEPMNGTIRVETPLSGSPYYTAVVQVRRPFDVSSANWLSHHCHMNSSLLTPADKIYADKGQLI-----DQEMPVAKDGVFYYTLQSGYLAIEIQIP-EGQSLLRHYFCRDAPSPRLASSAGT--------LTYSGDGLWTINITGSVTSTPAYVRLQLKDIGRRRLLLVQEWLIRQ 1127

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Sea Lamprey
Match: FBLN5 (fibulin 5 [Source:HGNC Symbol;Acc:HGNC:3602])

HSP 1 Score: 50.447 bits (119), Expect = 3.225e-6
Identity = 39/137 (28.47%), Postives = 60/137 (43.80%), Query Frame = 2

Query: 1058 PYLKAIPINIFS-------IDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF---SDGINCQTCDRCPEFQFDYNQCLDSKSTF 1438
            PY   + I+I         +D+ A S +  C  N++C  A         P S  C C  G+Q+  G C+DI+EC         G+  + C+NT GSY C C   +   S+  +C+  D C E       C ++  +F
Sbjct:  113 PYTSTVLIHIGECATECTDVDECATSSH-RCRPNQVCTNA---------PGSYTCRCPEGYQMVAGQCVDIDECRY-------GMCAQGCVNTQGSYTCQCSPGYVLSSNNRSCEDVDECVEGSPCSQLCFNTYGSF 232

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Sea Lamprey
Match: creld2 (cysteine-rich with EGF-like domains 2 [Source:NCBI gene;Acc:393495])

HSP 1 Score: 49.6766 bits (117), Expect = 5.452e-6
Identity = 25/69 (36.23%), Postives = 35/69 (50.72%), Query Frame = 2

Query: 1178 CDPVSQKCL---------CTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSD 1357
            CDP  + C          C RG+   +G C+D+NEC  E     C  +N++C+NT G Y+C C   F D
Sbjct:  233 CDPACEGCKAAGPDSCHKCLRGYTERDGVCVDVNEC-EEGLATQCVRENEVCVNTEGGYRCECGPGFHD 300

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Match: EDO49409 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGE3])

HSP 1 Score: 52.373 bits (124), Expect = 5.611e-8
Identity = 27/69 (39.13%), Postives = 40/69 (57.97%), Query Frame = 2

Query: 1184 PVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS-DGINCQTCDRC 1387
            P S  C C +GF+     C+D++EC +     +C LK   C+NT+GS++C C K F+ DG  CQ  + C
Sbjct:    5 PGSYDCKCNKGFKGDGKTCLDVDECADGTA--MCALKAS-CLNTLGSFRCNCIKGFTGDGKTCQDVNEC 70

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Match: EDO45017 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU36])

HSP 1 Score: 51.6026 bits (122), Expect = 2.938e-7
Identity = 30/84 (35.71%), Postives = 44/84 (52.38%), Query Frame = 2

Query: 1124 MCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTF-SDGINCQ 1372
            +C+ N +C            P S KC+C +G+  +   C D NEC  E  E  C  KN +C+NT GSY+CVC+  +  +G  C+
Sbjct:   52 LCNKNALCHNI---------PGSYKCMCLKGY--HGDDCHDANEC--ERGEHTCS-KNAMCINTSGSYECVCNDGYRGNGTICE 121

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Match: EDO31267 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYE0])

HSP 1 Score: 47.3654 bits (111), Expect = 2.999e-6
Identity = 25/69 (36.23%), Postives = 36/69 (52.17%), Query Frame = 2

Query: 1184 PVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS-DGINCQTCDRC 1387
            P S  C C  G+      C D+NEC   ++  +    N  C+NT+GSY C+C+  F+ DG +C   D C
Sbjct:    5 PGSYACACPVGYTANGRGCDDVNECGVSDSCHV----NGTCVNTVGSYGCICNAGFTGDGYSCSDVDEC 69

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Match: EDO30071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1U1])

HSP 1 Score: 47.7506 bits (112), Expect = 5.680e-6
Identity = 28/69 (40.58%), Postives = 36/69 (52.17%), Query Frame = 2

Query: 1184 PVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS-DGINCQTCDRC 1387
            P S  C C  G+ +    C D+NEC    ++R  G  N  C NTIGSY C C+  F+ +G NC   D C
Sbjct:    7 PGSYACACPAGYTVSGHRCNDLNEC--GVSDRCHG--NATCTNTIGSYTCTCNPGFTGNGFNCTDIDEC 71

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Match: EDO33472 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SS59])

HSP 1 Score: 47.3654 bits (111), Expect = 7.214e-6
Identity = 25/69 (36.23%), Postives = 36/69 (52.17%), Query Frame = 2

Query: 1184 PVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS-DGINCQTCDRC 1387
            P S  C C  G+      C D+NEC   ++  +    N  C+NT+GSY C+C+  F+ DG +C   D C
Sbjct:    7 PGSYACACPAGYTNNGHVCDDVNECGVSDSCHV----NGTCVNTVGSYGCICNAGFTGDGYSCSDVDEC 71

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Medaka
Match: nid2a (nidogen 2 [Source:NCBI gene;Acc:101173773])

HSP 1 Score: 55.0694 bits (131), Expect = 1.081e-6
Identity = 35/106 (33.02%), Postives = 53/106 (50.00%), Query Frame = 2

Query: 1082 NIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQL-YNG-ACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS-DGINCQTCDRCP 1390
            N + ID+ A  G   C  +  C            P S +CLC+RGF+  Y+G  C+DI+EC    +   C + N  C+N +GS++C+C   F+ DG  C   +  P
Sbjct:  745 NCYDIDECA-EGVSSCGEHSECLNL---------PGSHRCLCSRGFEFAYDGRTCVDIDEC----SSSPCHI-NARCINELGSFQCLCQPGFTGDGFFCSQQEDLP 835

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BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Medaka
Match: hmcn1 (hemicentin 1 [Source:NCBI gene;Acc:101172646])

HSP 1 Score: 53.1434 bits (126), Expect = 4.087e-6
Identity = 43/139 (30.94%), Postives = 67/139 (48.20%), Query Frame = 2

Query: 1202 LCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFS---DGINCQTCDRCPE--FQFDYNQ-CLDSKSTF-CIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNK 1597
            +C RGF+   G C+ INEC   +T   C  +   CMNT GS++C+C   +    +G  CQ  D C E   Q   N+ C + + ++ CID   P  P+   D      K+      E   S   L+ + L++  G++SN+
Sbjct: 5143 VCQRGFESRGGLCL-INECEMRDT---CQHE---CMNTPGSHRCLCPAGYRLMMNGKTCQDVDECLEQNIQCGMNRMCFNMRGSYECID--TPCPPNYQRDPATFCLKNCPPNDLECTLSHYALEYKLLSLPFGIASNQ 5272

HSP 2 Score: 52.373 bits (124), Expect = 8.201e-6
Identity = 34/86 (39.53%), Postives = 47/86 (54.65%), Query Frame = 2

Query: 1196 KCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCV--CDKTFSDGINCQTCDRCPE--FQFDYNQ-CLDSKSTF 1438
            +C C  GFQL N  CI INEC     +R+C   +++C NT GSY C+  C    + G N  T D C E   Q  YNQ C +++ ++
Sbjct: 4941 RCSCEPGFQLRNRRCI-INEC----RQRVC-RSDQLCKNTRGSYTCIDLCPSGMTKGAN-GTVDECREGTHQCSYNQICENTRGSY 5019

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Match: SMESG000077687.1 (SMESG000077687.1)

HSP 1 Score: 3437.89 bits (8913), Expect = 0.000e+0
Identity = 1847/1847 (100.00%), Postives = 1847/1847 (100.00%), Query Frame = 2

Query:  110 CDVNFRSKHESVNISKPFVDVIVIRFRGTGRISIKHSSNLNKNLIVANAKWKFQFQYEISSNYLRVIDNSIYHYGRTHLQVEVGYILRSWNWSIDIATIFLLIIFLGCVVICICLKLKEKFNCKFQRLQSVKGMFIQSKRKKKLKIYRPSQSKNETELFNEEITEMINFNNTSDQTETQLNNANTVFHFEKANSFDEESTDNNPDVIDSNSVNELIYKLQLTQRQQLYRVMRTXXXXXXXXXXXXXXXXXXXXXTNEHRNFDNSCYIQSLELIIPRSFEAGIIEIYHSNKKDLRHDHEDNEFQSNEKNLQVFNYLLPYLKAIPINIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELLNKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQIIHKSYYDTNQFFISENFQEKPFYFINNFHFEKKLFSSYETKNFAFQIEINDCFKNHKFKLYYFTKINLQLTHLNNSQIGNYQFTMGFINIANKITSITLSMGXXXXXXXXXXXXCSIWRKIKNKDNLWESIKPKLQNNKSNYTNISYKKKVFMLLYVAFRVFYTFXXXXXXXXXXXXXXXXXXNEFYGNQQRIFNWINQETKQINQLSTSEFKRQLQYSNNMKKACESHDISKINKLEREIISSLNGSIKHWYSIDSGSIINQSIDFSQQAITRYESRIDKISDKLQFNVKHRFLDRYGQYQELIKQFYFLQYFNVIQKVHNKSQQYSTQQTNNYPNTDKPFVENSMMQFLNFIEIYETKSLNFYPFQNLKNLQIQFERFYKNQKRWKTXXXXXXXXXXXXXXXXXXHRMFDAKSINYHQNSFVFDSAEKLPNSKKINIRSLTSFKILKARIFLMVIDCFIVIYRFYNTFEILKWIFLGRKMYVFNSVPKEIDKKIPTENVKRNQDDKIKFPTQSHYGLLPFSELSLRIISQNRFPDWSIINQNPSGYSSCFKSRKYFQSFGQMHXXXXXXXXXXXXXXXXXXXXXNYWYIKHYNPDVYKQNLEVLQKSQWLINLLSRKFSDYINNYALTNSKIHXXXXXXXXXXXXYHLSHNQKNVCQQLNWEIKSIRARSNTHSTLSFDICRSQSDVNFLPHLLMHISPCQFLSVLPINYSASAIISEKTNYKSDSINKINQXXXXXXXXXXTVSTFIGSVQIMGNVLIKSVLGSNDNSRYFFLTSTYPHANSVKIXXXXXXXXKGMRNHPICDSSSLLKRPLPTVTSGQFNDFSTSLHFFQLTATSESDV 5650
            CDVNFRSKHESVNISKPFVDVIVIRFRGTGRISIKHSSNLNKNLIVANAKWKFQFQYEISSNYLRVIDNSIYHYGRTHLQVEVGYILRSWNWSIDIATIFLLIIFLGCVVICICLKLKEKFNCKFQRLQSVKGMFIQSKRKKKLKIYRPSQSKNETELFNEEITEMINFNNTSDQTETQLNNANTVFHFEKANSFDEESTDNNPDVIDSNSVNELIYKLQLTQRQQLYRVMRTIFVLFCSILIISIFLFVIYLSTNEHRNFDNSCYIQSLELIIPRSFEAGIIEIYHSNKKDLRHDHEDNEFQSNEKNLQVFNYLLPYLKAIPINIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRSSVKVCQNSSKKSKSCCETKCYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELLNKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQIIHKSYYDTNQFFISENFQEKPFYFINNFHFEKKLFSSYETKNFAFQIEINDCFKNHKFKLYYFTKINLQLTHLNNSQIGNYQFTMGFINIANKITSITLSMGLIYLLIIIFYIFCSIWRKIKNKDNLWESIKPKLQNNKSNYTNISYKKKVFMLLYVAFRVFYTFLFTLSVSLSLLLGLDSYSNEFYGNQQRIFNWINQETKQINQLSTSEFKRQLQYSNNMKKACESHDISKINKLEREIISSLNGSIKHWYSIDSGSIINQSIDFSQQAITRYESRIDKISDKLQFNVKHRFLDRYGQYQELIKQFYFLQYFNVIQKVHNKSQQYSTQQTNNYPNTDKPFVENSMMQFLNFIEIYETKSLNFYPFQNLKNLQIQFERFYKNQKRWKTKFQTKPFKYKSKKKWKIFHRMFDAKSINYHQNSFVFDSAEKLPNSKKINIRSLTSFKILKARIFLMVIDCFIVIYRFYNTFEILKWIFLGRKMYVFNSVPKEIDKKIPTENVKRNQDDKIKFPTQSHYGLLPFSELSLRIISQNRFPDWSIINQNPSGYSSCFKSRKYFQSFGQMHFIAVTIVFVLLVALLTFVVVTNYWYIKHYNPDVYKQNLEVLQKSQWLINLLSRKFSDYINNYALTNSKIHNMNMSSLIINSSYHLSHNQKNVCQQLNWEIKSIRARSNTHSTLSFDICRSQSDVNFLPHLLMHISPCQFLSVLPINYSASAIISEKTNYKSDSINKINQLIFIFVLLIITVSTFIGSVQIMGNVLIKSVLGSNDNSRYFFLTSTYPHANSVKIHSSSSHSSKGMRNHPICDSSSLLKRPLPTVTSGQFNDFSTSLHFFQLTATSESDV
Sbjct:   27 CDVNFRSKHESVNISKPFVDVIVIRFRGTGRISIKHSSNLNKNLIVANAKWKFQFQYEISSNYLRVIDNSIYHYGRTHLQVEVGYILRSWNWSIDIATIFLLIIFLGCVVICICLKLKEKFNCKFQRLQSVKGMFIQSKRKKKLKIYRPSQSKNETELFNEEITEMINFNNTSDQTETQLNNANTVFHFEKANSFDEESTDNNPDVIDSNSVNELIYKLQLTQRQQLYRVMRTIFVLFCSILIISIFLFVIYLSTNEHRNFDNSCYIQSLELIIPRSFEAGIIEIYHSNKKDLRHDHEDNEFQSNEKNLQVFNYLLPYLKAIPINIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRSSVKVCQNSSKKSKSCCETKCYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELLNKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQIIHKSYYDTNQFFISENFQEKPFYFINNFHFEKKLFSSYETKNFAFQIEINDCFKNHKFKLYYFTKINLQLTHLNNSQIGNYQFTMGFINIANKITSITLSMGLIYLLIIIFYIFCSIWRKIKNKDNLWESIKPKLQNNKSNYTNISYKKKVFMLLYVAFRVFYTFLFTLSVSLSLLLGLDSYSNEFYGNQQRIFNWINQETKQINQLSTSEFKRQLQYSNNMKKACESHDISKINKLEREIISSLNGSIKHWYSIDSGSIINQSIDFSQQAITRYESRIDKISDKLQFNVKHRFLDRYGQYQELIKQFYFLQYFNVIQKVHNKSQQYSTQQTNNYPNTDKPFVENSMMQFLNFIEIYETKSLNFYPFQNLKNLQIQFERFYKNQKRWKTKFQTKPFKYKSKKKWKIFHRMFDAKSINYHQNSFVFDSAEKLPNSKKINIRSLTSFKILKARIFLMVIDCFIVIYRFYNTFEILKWIFLGRKMYVFNSVPKEIDKKIPTENVKRNQDDKIKFPTQSHYGLLPFSELSLRIISQNRFPDWSIINQNPSGYSSCFKSRKYFQSFGQMHFIAVTIVFVLLVALLTFVVVTNYWYIKHYNPDVYKQNLEVLQKSQWLINLLSRKFSDYINNYALTNSKIHNMNMSSLIINSSYHLSHNQKNVCQQLNWEIKSIRARSNTHSTLSFDICRSQSDVNFLPHLLMHISPCQFLSVLPINYSASAIISEKTNYKSDSINKINQLIFIFVLLIITVSTFIGSVQIMGNVLIKSVLGSNDNSRYFFLTSTYPHANSVKIHSSSSHSSKGMRNHPICDSSSLLKRPLPTVTSGQFNDFSTSLHFFQLTATSESDV 1873

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Match: SMESG000041540.1 (SMESG000041540.1)

HSP 1 Score: 350.903 bits (899), Expect = 9.177e-101
Identity = 225/677 (33.23%), Postives = 351/677 (51.85%), Query Frame = 2

Query: 1127 CDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGIN--CQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNL---SCMAFYTSKC-YDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKK-IDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELL-NKSIIRSFVCSEKS---GKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQII 3124
            CD    C  AW+QGR GC+P ++KC+C RGF+L  G C+D NEC        C   +K C NT G++ C C + FS   N  C  C +C    +D NQC+    T CID   P+   K    +   +    +  +ENVF +++L    L  ++        SS      SGL++ I L N+++ P+FED+ H  DN  IL S+QGS+ YHLK PL+ +++N+CR PLP  Y+ITM  Y  R+T A +  C   ++P +   C  D  +   +Y R++N++CS NKA  L  E + FYC +N++ VN+IF H + E +S      CD   +KC TC +        S  K          + L   +C   Y+S+C Y  +L K L  + IC++GDT KFTL P+FDF+N  F CH++K I +S  R+ I F++         W+S  IV+++      G+  I  I+  W++ ++S  +M L G+Q        + L K+ K    T  P K+ KH +  Y++ +    F +++ NW + SC+++     PI        Q V  +S  H      +  F Y + S     ++++E+  N S+I+S +C       G+++    N DS   QL   +WP  W +  EG VS+  TF+N++I DI ++S+L   +QI+
Sbjct:  353 CDEKHKCLIAWQQGRYGCNPNTKKCICQRGFRLLKGLCLDENECQIPLVSSFCESHSK-CFNTAGTHICSCSR-FSGTQNKHCSICQKCAVGSYDSNQCILPAETNCIDATQPV--KKVSKRIDNIKDIITIKPAENVFGKNILDTLKLKSNLQFQEFNGRSSETILGASGLIINITLLNVNLPPIFEDMEHKSDNEFILNSTQGSNLYHLKTPLLQIMKNYCRHPLPDSYFITMTTYTDRHTKAQRYNCNQMEHPFNNH-CHQDSTEYNSFYTRSINDQCSVNKAMFLSEELHSFYCVENNKLVNDIFKHNLKESVSYHPDPGCDYARRKCNTCKKKMCSKAGKSKSKKTIDENCCLTKCLNDKNCQIQYSSECHYTDRLKKGLD-QVICMQGDTAKFTLNPQFDFKNNKFKCHIRKQIPNSLMRVMIQFSI-----PGKGWSSSVIVEDVPYSD-PGNYNIGNITFYWSSKLNSHSQMILHGYQNPNHGQQFFSLSKINKNPS-TILP-KLQKHGDKSYIEVEFENIFEYSTSNWNSLSCKVNVSKIRPINRTIDYTLQNVMPVSIVH----SDRKPFTYILKSAIEDPEIEIEVKENTSLIKSLLCEGNQFHRGRIVKDIQN-DSFTAQLSLQKWPYQWNLLVEGFVSNDATFVNIQITDIATESLLADYEQIV 1010

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Match: SMESG000041540.1 (SMESG000041540.1)

HSP 1 Score: 330.487 bits (846), Expect = 5.005e-94
Identity = 217/677 (32.05%), Postives = 345/677 (50.96%), Query Frame = 2

Query: 1127 CDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYNGACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGIN--CQTCDRCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXXXXXXYRNL---SCMAFYTSKC-YDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLKK-IDDSKPRMTISFNLHIIDNDKPLWTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELL-NKSIIRSFVCSEKS---GKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQDQII 3124
            CD    C  AW+QGR GC+P ++KC+C RGF+L  G C+D NEC        C   +K C NT G++ C C + FS   N  C  C +C    +D NQC+    T CID   P+   K    +   +    +  +ENVF +++L    L  ++        SS      SGL++ I L N+++ P+FED+ H  DN  IL S+QGS+ YHLK PL+ +++N+CR PLP  Y+ITM  Y  R+T A +  C   ++P +   C  D  +   +Y R++N++CS NKA  L  E + FYC +N++ VN+IF H + E +S      CD   +KC TC +        S  K          + L   +C   Y+S+C Y  +L K L  + IC++GDT KFTL P+FDF+N  F CH++K I +S  R+ I F++         W+S  IV+++      G+  I  I+  W++ ++S  +M L G+Q        + L K+ K    T  P K+ KH +  Y++ ++ +  +   +N+       + +N  P+  ++                    +  F Y + S     ++++E+  N S+I+S +C       G+++    N DS   QL   +WP  W +  EG VS+  TF+N++I DI ++S+L   +QI+
Sbjct:  353 CDEKHKCLIAWQQGRYGCNPNTKKCICQRGFRLLKGLCLDENECQIPLVSSFCESHSK-CFNTAGTHICSCSR-FSGTQNKHCSICQKCAVGSYDSNQCILPAETNCIDATQPV--KKVSKRIDNIKDIITIKPAENVFGKNILDTLKLKSNLQFQEFNGRSSETILGASGLIINITLLNVNLPPIFEDMEHKSDNEFILNSTQGSNLYHLKTPLLQIMKNYCRHPLPDSYFITMTTYTDRHTKAQRYNCNQMEHPFNNH-CHQDSTEYNSFYTRSINDQCSVNKAMFLSEELHSFYCVENNKLVNDIFKHNLKESVSYHPDPGCDYARRKCNTCKKKMCSKAGKSKSKKTIDENCCLTKCLNDKNCQIQYSSECHYTDRLKKGLD-QVICMQGDTAKFTLNPQFDFKNNKFKCHIRKQIPNSLMRVMIQFSI-----PGKGWSSSVIVEDVPYSD-PGNYNIGNITFYWSSKLNSHSQMILHGYQNPNHGQQFFSLSKINKNPS-TILP-KLQKHGDKSYIEVEHVKLEFIVMQNY-------TLQNVMPVSIVH------------------SDRKPFTYILKSAIEDPEIEIEVKENTSLIKSLLCEGNQFHRGRIVKDIQN-DSFTAQLSLQKWPYQWNLLVEGFVSNDATFVNIQITDIATESLLADYEQIV 989

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Match: SMESG000016698.1 (SMESG000016698.1)

HSP 1 Score: 226.868 bits (577), Expect = 2.089e-59
Identity = 178/577 (30.85%), Postives = 281/577 (48.70%), Query Frame = 2

Query: 1523 SENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTH-SGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXX----XXXXYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLK----------KIDDSKPR-MTISFNLH---IIDNDKPLWTSKPI-VQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLY-LPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQVKVELLNK-SIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPTVWKIYFEGTVSDIPTFINVKIIDITSQSVLFHQD-QIIHKSYYDTNQFFISENFQEKP 3184
            + NVF EDLL   S N  I V+   QN+S    R+SG+ + I+L NI ++  ++DV H   DN  IL +   S    L+ PL+N+++N CR PLP +Y++T+  +++RYT   KIIC   +       CP  +++GQIY +RT+N++C+ NKA+ LP + + FYCTQNS  +N+IF+ +I EKI +     C ++ K C+ C R        S              +C    SC+ +Y+  CY   +D + H  N+C+KG T +FTL P+F F N+SF+CH+           KI  S P  M + F+L       N K   T+ P+   E  L K   H+F                  Y +    H  KS  + LYK+K++   TK  +K  KH   KY + Q   PF  NS NW+  SC  + ++ Y  Q LY   +   +K+L      +  +  AF Y +++      + +    K SI++S +CS               +F       W   W +  +G V     ++NVK+++ +   ++F++D  I+     + N F ++ N Q  P
Sbjct:   72 TSNVFMEDLLLETSFNHIITVNKVNQNASIEIIRRSGIKMTIDLVNIKLHFKYQDVEHPESDNDFILHAKSPSVAADLQKPLLNIIQNFCREPLPDHYFLTVTPFKNRYTRGNKIICNQIQMTTGSVRCPEHYYNGQIYAYRTVNDQCTHNKATYLPQDTDKFYCTQNSPILNSIFHEKITEKIELQSFGECQLHRKNCEKCFRPRCASHFKSIDSYDYENCCQFIAQCLLQPSCIDYYSPTCY--YVDLAEHQHNLCIKGSTYQFTLNPQFSFNNKSFMCHMSLEKEKIIYQVKIKVSIPHWMKLEFHLSENVTRPNIKGKLTTTPVYTYESTLMKMQ-HRF--------------RINEYFQDAILHF-KSNKFHLYKLKERFSETKPIIK--KHHQIKYTKIQASYPFAVNSRNWHKRSCYTNIEDLYENQLLYNESENISIKLL----KLEKNNFQAFNYYVNNIDQSHDINIAFPEKSSILKSAICSLHHLNSRSNLSELKINFALKSQFNW--TWFLEIKGEVESSYEYLNVKLLEKSKSKIVFNKDILIVELPVSEKNVFSVNHNLQFFP 622

[Close]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Match: SMESG000016698.1 (SMESG000016698.1)

HSP 1 Score: 214.927 bits (546), Expect = 3.036e-59
Identity = 151/437 (34.55%), Postives = 224/437 (51.26%), Query Frame = 2

Query: 1523 SENVFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMFEDVTH-SGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNEYRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKASLLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLRXXXXXXXXXXXXXXXXX----XXXXYRNLSCMAFYTSKCYDGKLDKSLHAENICLKGDTLKFTLLPKFDFENESFLCHLK----------KIDDSKPR-MTISFNLH---IIDNDKPLWTSKPI-VQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKSISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSCRLSTKNFYPIQDLY 2773
            + NVF EDLL   S N  I V+   QN+S    R+SG+ + I+L NI ++  ++DV H   DN  IL +   S    L+ PL+N+++N CR PLP +Y++T+  +++RYT   KIIC   +       CP  +++GQIY +RT+N++C+ NKA+ LP + + FYCTQNS  +N+IF+ +I EKI +     C ++ K C+ C R        S              +C    SC+ +Y+  CY   +D + H  N+C+KG T +FTL P+F F N+SF+CH+           KI  S P  M + F+L       N K   T+ P+   E  L K   H+F                  Y +    H  KS  + LYK+K++   TK  +K  KH   KY + Q   PF  NS NW+  SC  + ++ Y  Q LY
Sbjct:   72 TSNVFMEDLLLETSFNHIITVNKVNQNASIEIIRRSGIKMTIDLVNIKLHFKYQDVEHPESDNDFILHAKSPSVAADLQKPLLNIIQNFCREPLPDHYFLTVTPFKNRYTRGNKIICNQIQMTTGSVRCPEHYYNGQIYAYRTVNDQCTHNKATYLPQDTDKFYCTQNSPILNSIFHEKITEKIELQSFGECQLHRKNCEKCFRPRCASHFKSIDSYDYENCCQFIAQCLLQPSCIDYYSPTCY--YVDLAEHQHNLCIKGSTYQFTLNPQFSFNNKSFMCHMSLEKEKIIYQVKIKVSIPHWMKLEFHLSENVTRPNIKGKLTTTPVYTYESTLMKMQ-HRF--------------RINEYFQDAILHF-KSNKFHLYKLKERFSETKPIIK--KHHQIKYTKIQASYPFAVNSRNWHKRSCYTNIEDLYENQLLY 488

The following BLAST results are available for this feature:

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Fly
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Zebrafish
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Cavefish
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Sea Lamprey
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Yeast
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Medaka
BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HMCN1	1.806e-6	32.11	hemicentin 1 [Source:HGNC Symbol;Acc:HGNC:19194]	[more]
LTBP1	1.844e-6	36.67	latent transforming growth factor beta binding pro...	[more]
HMCN2	5.486e-6	30.63	hemicentin 2 [Source:HGNC Symbol;Acc:HGNC:21293]	[more]
LTBP2	5.549e-6	41.43	latent transforming growth factor beta binding pro...	[more]
LTBP2	5.574e-6	41.43	latent transforming growth factor beta binding pro...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mec-1	4.385e-8	33.88	pep chromosome:WBcel235:V:6956537:6961338:1 gene:W...	[more]
mec-1	6.418e-8	33.88	pep chromosome:WBcel235:V:6956537:6961061:1 gene:W...	[more]
mec-1	1.107e-7	33.61	pep chromosome:WBcel235:V:6956542:6966422:1 gene:W...	[more]
mec-1	1.107e-7	33.61	pep chromosome:WBcel235:V:6956537:6966422:1 gene:W...	[more]
mec-1	1.107e-7	33.61	pep chromosome:WBcel235:V:6956542:6966422:1 gene:W...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
hmcn1	1.233e-7	35.64	hemicentin 1 [Source:ZFIN;Acc:ZDB-GENE-041014-322]	[more]
hmcn1	1.233e-7	35.64	hemicentin 1 [Source:ZFIN;Acc:ZDB-GENE-041014-322]	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000024069.1	1.060e-6	34.74	hemicentin 2 [Source:NCBI gene;Acc:100490941]	[more]
nid2	1.813e-6	36.36	nidogen 2 [Source:NCBI gene;Acc:100036716]	[more]
CRELD2	3.725e-6	36.14	cysteine rich with EGF-like domains 2 [Source:NCBI...	[more]
CRELD2	5.357e-6	45.10	cysteine rich with EGF-like domains 2 [Source:NCBI...	[more]
CRELD2	5.515e-6	45.10	cysteine rich with EGF-like domains 2 [Source:NCBI...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hmcn1	2.864e-8	30.91	hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]	[more]
Ltbp2	3.656e-7	37.78	latent transforming growth factor beta binding pro...	[more]
Ltbp2	3.662e-7	37.78	latent transforming growth factor beta binding pro...	[more]
Ltbp2	3.826e-7	37.78	latent transforming growth factor beta binding pro...	[more]
Ltbp1	9.661e-7	36.67	latent transforming growth factor beta binding pro...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q00918\|LTBP1_RAT	3.717e-6	37.78	Latent-transforming growth factor beta-binding pro...	[more]
sp\|O08999\|LTBP2_MOUSE	3.910e-6	37.78	Latent-transforming growth factor beta-binding pro...	[more]
sp\|B5DFC9\|NID2_RAT	5.290e-6	31.97	Nidogen-2 OS=Rattus norvegicus OX=10116 GN=Nid2 PE...	[more]
sp\|O88322\|NID2_MOUSE	6.992e-6	31.97	Nidogen-2 OS=Mus musculus OX=10090 GN=Nid2 PE=1 SV...	[more]
sp\|Q8CG19\|LTBP1_MOUSE	7.476e-6	36.67	Latent-transforming growth factor beta-binding pro...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2R2ML22	1.388e-52	24.55	uncharacterized protein LOC106172251 isoform X3 OS...	[more]
A0A2R2MLG8	4.219e-52	24.52	uncharacterized protein LOC106172251 isoform X2 OS...	[more]
A0A2R2ML12	4.291e-52	24.52	uncharacterized protein LOC106172251 isoform X1 OS...	[more]
A0A4E0RZ73	3.067e-47	28.04	Uncharacterized protein OS=Fasciola hepatica OX=61...	[more]
A0A267GV26	1.936e-44	23.42	Uncharacterized protein (Fragment) OS=Macrostomum ...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
FBLN5	3.225e-6	28.47	fibulin 5 [Source:HGNC Symbol;Acc:HGNC:3602]	[more]
creld2	5.452e-6	36.23	cysteine-rich with EGF-like domains 2 [Source:NCBI...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49409	5.611e-8	39.13	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45017	2.938e-7	35.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31267	2.999e-6	36.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30071	5.680e-6	40.58	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33472	7.214e-6	36.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nid2a	1.081e-6	33.02	nidogen 2 [Source:NCBI gene;Acc:101173773]	[more]
hmcn1	4.087e-6	30.94	hemicentin 1 [Source:NCBI gene;Acc:101172646]	[more]

BLAST of Cysteine rich with EGF like domains 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000077687.1	0.000e+0	100.00	SMESG000077687.1	[more]
SMESG000041540.1	9.177e-101	33.23	SMESG000041540.1	[more]
SMESG000041540.1	5.005e-94	32.05	SMESG000041540.1	[more]
SMESG000016698.1	2.089e-59	30.85	SMESG000016698.1	[more]
SMESG000016698.1	3.036e-59	34.55	SMESG000016698.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30001901 ID=SMED30001901|Name=Cysteine rich with EGF like domains 2|organism=Schmidtea mediterranea sexual|type=transcript|length=5832bp
AACCGAAAATTTATATCTTTAATAAAATAACATGATTTCTCGTTTAACAA
TCGGAATTTACATTTTCATTATAATTCTAATAATATTTTCTTCATCAAAT
TCAACAATTTGTGATGTAAATTTTCGATCCAAACACGAATCAGTAAATAT
TAGCAAACCATTTGTGGATGTTATAGTTATTCGGTTTCGAGGAACGGGTC
GCATTAGCATAAAGCATTCATCAAATCTAAACAAAAATTTAATAGTCGCC
AATGCCAAATGGAAATTCCAATTTCAATACGAAATCTCTTCAAATTATCT
GCGAGTTATTGATAATAGCATTTATCATTATGGAAGGACTCATCTCCAAG
TTGAAGTGGGGTACATTTTACGAAGTTGGAATTGGTCAATTGATATAGCA
ACAATATTTTTGCTAATAATCTTTTTAGGATGTGTTGTGATATGCATTTG
CCTAAAGCTAAAAGAAAAGTTTAATTGTAAATTTCAACGATTACAATCAG
TAAAAGGAATGTTTATACAAAGCAAACGAAAGAAAAAGTTAAAAATCTAT
CGGCCATCGCAATCAAAAAATGAAACAGAATTATTCAACGAAGAAATCAC
TGAAATGATCAATTTTAACAATACTTCAGATCAAACTGAAACTCAGCTAA
ACAATGCTAATACCGTTTTTCATTTCGAAAAAGCAAATTCATTTGATGAA
GAATCAACAGACAATAATCCCGATGTGATTGATTCAAACAGTGTCAACGA
ATTAATATATAAATTGCAACTTACTCAAAGACAGCAGCTCTATCGTGTAA
TGAGAACGATCTTCGTTCTTTTTTGTAGTATCTTGATTATATCTATCTTT
CTTTTTGTCATTTATTTGTCTACGAATGAACACAGGAACTTCGACAACAG
TTGTTACATTCAATCGCTTGAACTGATAATCCCACGATCATTTGAAGCAG
GAATTATAGAAATATATCACAGCAATAAAAAGGATCTTCGACATGACCAT
GAAGACAACGAATTTCAGAGCAATGAGAAAAATCTTCAAGTGTTTAATTA
TCTGCTTCCGTATTTGAAAGCAATTCCCATAAATATTTTCAGCATAGATG
ATGCTGCAGCTAGTGGTTATCCGATGTGTGATGCTAATGAGATATGTCAA
ACAGCATGGCGACAAGGAAGATTAGGTTGTGATCCTGTTTCACAGAAGTG
TCTTTGTACACGAGGATTTCAGTTATATAATGGAGCTTGTATTGATATAA
ACGAATGTTTGAATGAAAATACAGAAAGATTGTGCGGACTTAAAAATAAA
ATCTGCATGAACACCATTGGGTCTTACAAATGTGTATGTGATAAAACATT
TTCCGACGGAATTAACTGTCAAACCTGTGACCGTTGCCCAGAATTTCAAT
TTGACTACAATCAATGTTTGGACAGTAAAAGCACTTTCTGCATTGATATT
CGTAATCCTCTGTTGCCTGATAAATCTGATGATCATTTAAAAGAAGATCG
TAAAAGTTATAAGTTGATCAGTTCTGAAAATGTATTTAGTGAAGATCTTT
TACAGTTGGAGTCGCTGAATATTTCGATTGGAGTTTCATCGAATAAACAA
AATTCATCCTTCATTTTTAATCGGAAATCTGGATTAGTTGTGAGAATAAA
TCTTAACAATATTAGCATGAACCCAATGTTCGAAGACGTAACACATTCGG
GAGATAATAGCATAATTCTGAAATCTTCACAAGGAAGCAGTACATATCAT
TTAAAAAATCCTTTAATGAATGTATTGAGGAATCATTGCCGGTTTCCATT
ACCGAAATATTATTACATCACAATGAATGAGTACCGACATCGTTATACAA
CAGCGGTAAAAATTATTTGCGCCAATCAGAAATATCCAGGAAGTAAAGAA
TTCTGTCCTGCAGATTTCTTTGACGGACAGATTTATTATTTCAGAACTTT
AAATAATCGTTGCAGTTCGAATAAAGCAAGTTTGTTGCCTTTTGAAAGAA
ATGGTTTCTACTGTACACAAAATTCAGAATTTGTAAATAATATTTTCAAT
CATCAAATTGATGAAAAAATATCAGTATCACAAAAGTCTATTTGTGATGT
CTATTACAAAAAGTGCAAGACTTGCTTGAGAAGCTCTGTCAAAGTGTGCC
AAAATTCATCAAAAAAATCAAAATCATGCTGCGAGACTAAATGTTATCGA
AATTTGAGTTGCATGGCATTTTATACTTCAAAATGTTACGACGGTAAATT
AGATAAAAGTTTACACGCAGAAAATATATGTTTAAAAGGAGATACATTAA
AATTTACACTTCTACCAAAATTCGATTTTGAAAATGAGTCTTTCTTATGT
CATCTCAAGAAAATTGATGATTCTAAGCCACGGATGACAATATCTTTTAA
TTTGCACATAATTGATAATGATAAACCTTTATGGACCAGTAAACCAATAG
TTCAAGAAATTATGCTTGATAAATTTAGCGGGCACAAATTCATAGATTTT
ATTTCACTGAATTGGACTAATTTTATCGATTCCGAAAAGGAAATGTACCT
AAAAGGCTTTCAAGAACATGGAACTAAATCCATCTCTTATAGATTGTATA
AAATGAAAAAAAAGAAAGACTTCACTAAAGGACCAATGAAAGTATATAAA
CATCAAAACAGTAAATATTTACAATTTCAGAATTGGCAGCCATTTTATTT
TAATTCTGAAAATTGGTATAATTTCTCTTGTCGATTATCAACAAAAAACT
TTTATCCAATTCAAGATCTTTATTTACCTGATTATCAAAGAGTCAAAGTA
CTCAGTAAGAATCATGATTCAAAAGGCGAATCAAAATCAGCGTTTAAATA
TACCATAGATTCCTTCCACAACCCTTCACAGGTCAAAGTTGAGTTATTAA
ATAAATCGATAATCCGATCATTTGTTTGCAGTGAAAAAAGTGGAAAATTG
ATTATTCCAACTGGAAATTTTGACAGTCATTTTCTTCAATTAATTAGCGT
GCGCTGGCCAACAGTTTGGAAAATTTATTTTGAAGGTACGGTCAGTGACA
TTCCTACATTTATCAATGTTAAAATAATTGATATAACTAGCCAATCAGTT
CTTTTTCATCAAGATCAAATAATTCATAAATCATATTACGACACGAACCA
ATTTTTCATTAGTGAAAATTTTCAAGAGAAACCATTTTATTTTATCAACA
ATTTCCATTTTGAAAAGAAATTATTTTCCAGTTATGAAACAAAAAACTTT
GCTTTCCAAATCGAAATTAATGACTGTTTCAAAAATCACAAATTTAAATT
GTATTATTTCACGAAAATCAACTTGCAATTGACTCATTTAAACAACAGTC
AAATCGGTAATTATCAATTCACTATGGGTTTCATTAATATTGCAAATAAA
ATAACTTCGATAACGTTGAGCATGGGTTTGATTTATTTATTAATAATCAT
ATTCTACATTTTCTGTTCGATATGGAGAAAAATAAAAAATAAAGATAACC
TTTGGGAGAGTATCAAACCAAAGTTGCAAAACAACAAATCAAATTATACA
AATATATCATACAAAAAGAAAGTGTTTATGTTGTTATATGTTGCGTTTCG
AGTTTTTTACACGTTTTTATTTACACTGAGTGTCAGTTTATCATTATTAC
TCGGACTTGATTCGTATTCAAATGAATTCTATGGAAATCAACAGCGAATC
TTCAACTGGATCAATCAAGAAACAAAACAAATCAACCAGCTCTCTACTTC
AGAATTTAAACGACAATTGCAATATTCAAACAACATGAAAAAAGCTTGCG
AAAGTCACGATATATCAAAGATCAATAAACTGGAACGAGAGATCATTTCC
TCACTGAACGGATCAATAAAACATTGGTATAGTATTGATTCTGGATCAAT
TATCAATCAGTCGATCGATTTCTCACAACAGGCGATCACTCGATATGAAA
GCCGAATCGATAAAATATCCGATAAACTGCAATTCAATGTGAAACATCGA
TTTCTTGATCGGTATGGGCAATATCAAGAACTGATCAAGCAGTTTTATTT
TCTTCAATATTTTAATGTCATTCAAAAAGTCCACAACAAATCCCAACAAT
ATTCCACTCAACAAACAAATAATTATCCCAACACCGATAAACCGTTTGTG
GAAAATTCAATGATGCAATTTCTCAATTTTATCGAAATCTATGAAACAAA
ATCTCTGAATTTCTATCCATTTCAGAACCTGAAAAACTTGCAAATTCAGT
TTGAAAGATTTTATAAAAATCAAAAGAGATGGAAAACAAAATTCCAAACG
AAACCATTCAAATACAAATCAAAGAAAAAATGGAAAATCTTTCATCGTAT
GTTTGACGCCAAAAGCATCAATTACCACCAAAATAGTTTTGTATTTGATA
GTGCCGAAAAACTACCGAACTCAAAGAAAATCAACATTAGATCTTTGACA
AGTTTTAAAATATTGAAAGCAAGAATTTTTCTCATGGTTATAGATTGTTT
TATTGTGATTTATCGATTTTATAACACTTTTGAAATATTGAAATGGATAT
TTCTTGGTCGGAAGATGTACGTGTTTAATTCAGTTCCAAAGGAAATTGAT
AAAAAGATACCAACTGAAAACGTGAAACGCAATCAAGACGACAAAATCAA
ATTTCCAACTCAATCGCATTACGGATTGCTGCCATTCAGTGAATTATCAT
TAAGAATAATCAGTCAAAACCGATTCCCAGACTGGTCCATTATCAATCAA
AATCCATCTGGTTACAGTTCCTGTTTCAAATCACGAAAATATTTTCAGAG
TTTTGGCCAAATGCATTTCATTGCTGTGACAATTGTCTTTGTTTTGCTAG
TTGCACTCTTAACTTTTGTAGTTGTCACCAATTATTGGTATATCAAACAT
TATAATCCCGATGTTTATAAACAAAACCTCGAAGTCCTTCAAAAGTCTCA
ATGGCTAATTAACTTATTATCCAGAAAGTTTAGCGATTATATCAACAATT
ATGCACTTACAAATTCAAAGATTCACAATATGAATATGAGCAGCTTGATT
ATCAATAGTTCTTACCACCTTTCACATAACCAGAAAAATGTTTGTCAGCA
GTTGAACTGGGAAATCAAATCAATCAGAGCCAGATCAAATACTCATTCAA
CTCTTTCATTCGACATTTGCCGTTCGCAATCAGATGTTAATTTTTTGCCT
CACCTTCTAATGCACATCAGTCCATGTCAATTCCTCAGTGTTTTGCCCAT
CAACTATTCTGCATCTGCAATTATTTCTGAAAAAACAAACTACAAATCAG
ATTCAATCAACAAAATTAATCAATTAATTTTTATTTTTGTTTTACTGATA
ATCACAGTATCAACTTTCATTGGCTCTGTTCAAATTATGGGAAATGTTTT
GATAAAATCAGTATTAGGATCCAATGATAACAGTCGCTATTTTTTTCTTA
CATCAACTTATCCCCACGCCAATTCGGTGAAAATTCATTCCTCATCTTCT
CATTCGAGTAAAGGTATGCGAAATCACCCGATTTGCGATTCAAGCAGTCT
ACTAAAACGTCCCCTTCCAACTGTGACAAGTGGTCAATTCAATGATTTTT
CAACATCCCTTCATTTTTTTCAACTGACCGCTACTTCAGAGTCTGATGTG
TGAAAGCCAAAGCAAAAATGAAAAAAATTACAAGAAAACAAAACTTTCAC
AATTTTAAACAATTTGTTTTAAAATTCCGTTTGGTTGTTTGAGATATTTT
TATTCTTTTATTGAATTTTTAGCCATTGAAAATATTCGAATTTTTCTATA
ATAATTAAATTAATTTAATAATAATTTTCCGG

protein sequence of SMED30001901-orf-1

>SMED30001901-orf-1 ID=SMED30001901-orf-1|Name=SMED30001901-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1874bp
MISRLTIGIYIFIIILIIFSSSNSTICDVNFRSKHESVNISKPFVDVIVI
RFRGTGRISIKHSSNLNKNLIVANAKWKFQFQYEISSNYLRVIDNSIYHY
GRTHLQVEVGYILRSWNWSIDIATIFLLIIFLGCVVICICLKLKEKFNCK
FQRLQSVKGMFIQSKRKKKLKIYRPSQSKNETELFNEEITEMINFNNTSD
QTETQLNNANTVFHFEKANSFDEESTDNNPDVIDSNSVNELIYKLQLTQR
QQLYRVMRTIFVLFCSILIISIFLFVIYLSTNEHRNFDNSCYIQSLELII
PRSFEAGIIEIYHSNKKDLRHDHEDNEFQSNEKNLQVFNYLLPYLKAIPI
NIFSIDDAAASGYPMCDANEICQTAWRQGRLGCDPVSQKCLCTRGFQLYN
GACIDINECLNENTERLCGLKNKICMNTIGSYKCVCDKTFSDGINCQTCD
RCPEFQFDYNQCLDSKSTFCIDIRNPLLPDKSDDHLKEDRKSYKLISSEN
VFSEDLLQLESLNISIGVSSNKQNSSFIFNRKSGLVVRINLNNISMNPMF
EDVTHSGDNSIILKSSQGSSTYHLKNPLMNVLRNHCRFPLPKYYYITMNE
YRHRYTTAVKIICANQKYPGSKEFCPADFFDGQIYYFRTLNNRCSSNKAS
LLPFERNGFYCTQNSEFVNNIFNHQIDEKISVSQKSICDVYYKKCKTCLR
SSVKVCQNSSKKSKSCCETKCYRNLSCMAFYTSKCYDGKLDKSLHAENIC
LKGDTLKFTLLPKFDFENESFLCHLKKIDDSKPRMTISFNLHIIDNDKPL
WTSKPIVQEIMLDKFSGHKFIDFISLNWTNFIDSEKEMYLKGFQEHGTKS
ISYRLYKMKKKKDFTKGPMKVYKHQNSKYLQFQNWQPFYFNSENWYNFSC
RLSTKNFYPIQDLYLPDYQRVKVLSKNHDSKGESKSAFKYTIDSFHNPSQ
VKVELLNKSIIRSFVCSEKSGKLIIPTGNFDSHFLQLISVRWPTVWKIYF
EGTVSDIPTFINVKIIDITSQSVLFHQDQIIHKSYYDTNQFFISENFQEK
PFYFINNFHFEKKLFSSYETKNFAFQIEINDCFKNHKFKLYYFTKINLQL
THLNNSQIGNYQFTMGFINIANKITSITLSMGLIYLLIIIFYIFCSIWRK
IKNKDNLWESIKPKLQNNKSNYTNISYKKKVFMLLYVAFRVFYTFLFTLS
VSLSLLLGLDSYSNEFYGNQQRIFNWINQETKQINQLSTSEFKRQLQYSN
NMKKACESHDISKINKLEREIISSLNGSIKHWYSIDSGSIINQSIDFSQQ
AITRYESRIDKISDKLQFNVKHRFLDRYGQYQELIKQFYFLQYFNVIQKV
HNKSQQYSTQQTNNYPNTDKPFVENSMMQFLNFIEIYETKSLNFYPFQNL
KNLQIQFERFYKNQKRWKTKFQTKPFKYKSKKKWKIFHRMFDAKSINYHQ
NSFVFDSAEKLPNSKKINIRSLTSFKILKARIFLMVIDCFIVIYRFYNTF
EILKWIFLGRKMYVFNSVPKEIDKKIPTENVKRNQDDKIKFPTQSHYGLL
PFSELSLRIISQNRFPDWSIINQNPSGYSSCFKSRKYFQSFGQMHFIAVT
IVFVLLVALLTFVVVTNYWYIKHYNPDVYKQNLEVLQKSQWLINLLSRKF
SDYINNYALTNSKIHNMNMSSLIINSSYHLSHNQKNVCQQLNWEIKSIRA
RSNTHSTLSFDICRSQSDVNFLPHLLMHISPCQFLSVLPINYSASAIISE
KTNYKSDSINKINQLIFIFVLLIITVSTFIGSVQIMGNVLIKSVLGSNDN
SRYFFLTSTYPHANSVKIHSSSSHSSKGMRNHPICDSSSLLKRPLPTVTS
GQFNDFSTSLHFFQLTATSESDV*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR011528	NERD
IPR001881	EGF-like_Ca-bd_dom
IPR018097	EGF_Ca-bd_CS
IPR000152	EGF-type_Asp/Asn_hydroxyl_site
IPR001368	TNFR/NGFR_Cys_rich_reg
IPR000742	EGF-like_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0003674	molecular_function
GO:0019838	growth factor binding

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0030425	dendrite
GO:0031012	extracellular matrix
GO:0038045	large latent transforming growth factor-beta complex
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0032967	positive regulation of collagen biosynthetic process
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0042060	wound healing
GO:0071260	cellular response to mechanical stimulus
GO:0071305	cellular response to vitamin D
GO:0071374	cellular response to parathyroid hormone stimulus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001881	EGF-like calcium-binding domain	SMART	SM00179	egfca_6	coord: 405..447 e-value: 6.9E-7 score: 38.9
None	No IPR available	GENE3D	G3DSA:2.10.25.10		coord: 366..448 e-value: 4.0E-8 score: 35.2
None	No IPR available	PANTHER	PTHR24034	FAMILY NOT NAMED	coord: 387..724
None	No IPR available	PANTHER	PTHR24034:SF43	LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4	coord: 387..724
None	No IPR available	CDD	cd00054	EGF_CA	coord: 405..447 e-value: 7.79992E-7 score: 45.3202
None	No IPR available	TMHMM	TMhelix		coord: 7..26
None	No IPR available	TMHMM	TMhelix		coord: 119..141
None	No IPR available	TMHMM	TMhelix		coord: 1599..1621
None	No IPR available	TMHMM	TMhelix		coord: 1181..1203
None	No IPR available	TMHMM	TMhelix		coord: 1765..1787
None	No IPR available	TMHMM	TMhelix		coord: 260..279
None	No IPR available	TMHMM	TMhelix		coord: 1124..1146
IPR000152	EGF-type aspartate/asparagine hydroxylation site	PROSITE	PS00010	ASX_HYDROXYL	coord: 425..436
IPR018097	EGF-like calcium-binding, conserved site	PROSITE	PS01187	EGF_CA	coord: 405..434
IPR001368	TNFR/NGFR cysteine-rich region	PROSITE	PS00652	TNFR_NGFR_1	coord: 434..470
IPR000742	EGF-like domain	PROSITE	PS50026	EGF_3	coord: 405..447 score: 9.098

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Cysteine rich with EGF like domains 2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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