HTH CENPB-type domain-containing protein

Overview


Name	HTH CENPB-type domain-containing protein
Smed ID	SMED30001899
Length (bp)	932

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of HTH CENPB-type domain-containing protein (SMED30001899) t-SNE clustered cells

Violin plots show distribution of expression levels for HTH CENPB-type domain-containing protein (SMED30001899) in cells (dots) of each of the 12 neoblast clusters.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001899

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
oocyte	SMED30001899	h1SMcG0003502	Contig21330	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30001899	h1SMcG0003502	Contig21330	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30001899	h1SMcG0003502	Contig21330	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30001899	h1SMcG0003502	Contig21330	newmark_ests	PMID:28434803 Rouhana et al., 2017
epidermis	SMED30001899	h1SMcG0003502	dd_Smed_v4_10804_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: POGK (pogo transposable element derived with KRAB domain [Source:HGNC Symbol;Acc:HGNC:18800])

HSP 1 Score: 86.2705 bits (212), Expect = 4.372e-18
Identity = 62/237 (26.16%), Postives = 112/237 (47.26%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLK--LYLEQKKITVELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + LP+   EK+ + +  +   ++    E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  198 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 434

[Close]

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLK--LYLEQKKITVELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + LP+   EK+ + +  +   ++    E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  198 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 434

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: POGZ (pogo transposable element derived with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801])

HSP 1 Score: 51.2174 bits (121), Expect = 6.268e-7
Identity = 47/176 (26.70%), Postives = 83/176 (47.16%), Query Frame = 3

Query:  231 ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKI---TVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNE 728
            E + +L +WVL  ++  + V+   +  KA KI        F  + +W   FM R+ L+  A  +V+ +LP+   E  A L +   Q++I    + LS I +IDE+ +  D     ++D       ++G TG   CD  +VL +  DG     +V ++    Q   + + IL++  E
Sbjct: 1026 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLE-GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAEN-AGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVG-TGEPWCD--VVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKE 1196

HSP 2 Score: 21.557 bits (44), Expect = 6.268e-7
Identity = 7/18 (38.89%), Postives = 10/18 (55.56%), Query Frame = 1

Query:  733 GWMDEQIFGEWLTEAWGK 786
            G+ D++I   W T  W K
Sbjct: 1198 GYSDDEIMELWSTRVWQK 1215

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: POGZ (pogo transposable element derived with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801])

HSP 1 Score: 51.2174 bits (121), Expect = 6.276e-7
Identity = 47/176 (26.70%), Postives = 83/176 (47.16%), Query Frame = 3

Query:  231 ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKI---TVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNE 728
            E + +L +WVL  ++  + V+   +  KA KI        F  + +W   FM R+ L+  A  +V+ +LP+   E  A L +   Q++I    + LS I +IDE+ +  D     ++D       ++G TG   CD  +VL +  DG     +V ++    Q   + + IL++  E
Sbjct:  982 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLE-GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAEN-AGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVG-TGEPWCD--VVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKE 1152

HSP 2 Score: 21.557 bits (44), Expect = 6.276e-7
Identity = 7/18 (38.89%), Postives = 10/18 (55.56%), Query Frame = 1

Query:  733 GWMDEQIFGEWLTEAWGK 786
            G+ D++I   W T  W K
Sbjct: 1154 GYSDDEIMELWSTRVWQK 1171

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: POGZ (pogo transposable element derived with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801])

HSP 1 Score: 51.2174 bits (121), Expect = 6.277e-7
Identity = 47/176 (26.70%), Postives = 83/176 (47.16%), Query Frame = 3

Query:  231 ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKI---TVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNE 728
            E + +L +WVL  ++  + V+   +  KA KI        F  + +W   FM R+ L+  A  +V+ +LP+   E  A L +   Q++I    + LS I +IDE+ +  D     ++D       ++G TG   CD  +VL +  DG     +V ++    Q   + + IL++  E
Sbjct:  973 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLE-GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAEN-AGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVG-TGEPWCD--VVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKE 1143

HSP 2 Score: 21.557 bits (44), Expect = 6.277e-7
Identity = 7/18 (38.89%), Postives = 10/18 (55.56%), Query Frame = 1

Query:  733 GWMDEQIFGEWLTEAWGK 786
            G+ D++I   W T  W K
Sbjct: 1145 GYSDDEIMELWSTRVWQK 1162

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Match: CR352209.1 (pep chromosome:GRCz11:24:26088143:26089609:1 gene:ENSDARG00000103972.2 transcript:ENSDART00000171129.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR352209.1)

HSP 1 Score: 190.66 bits (483), Expect = 2.490e-57
Identity = 98/241 (40.66%), Postives = 151/241 (62.66%), Query Frame = 3

Query:   39 REKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
            +   Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   GI++K N+K
Sbjct:    5 KRHAYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCSN-KITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGIIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Match: BX914205.2 (pep chromosome:GRCz11:4:64121772:64123545:-1 gene:ENSDARG00000099590.2 transcript:ENSDART00000170040.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX914205.2)

HSP 1 Score: 189.889 bits (481), Expect = 4.564e-57
Identity = 97/241 (40.25%), Postives = 151/241 (62.66%), Query Frame = 3

Query:   39 REKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
            +   Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   G+++K N+K
Sbjct:    5 KRHAYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCSN-KITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGVIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Match: CR354398.1 (pep chromosome:GRCz11:7:64150332:64152087:-1 gene:ENSDARG00000101994.2 transcript:ENSDART00000165234.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR354398.1)

HSP 1 Score: 189.889 bits (481), Expect = 9.872e-57
Identity = 97/238 (40.76%), Postives = 150/238 (63.03%), Query Frame = 3

Query:   48 CYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
             Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   G+++K N+K
Sbjct:    8 AYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCS-NKITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGVIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Pogk (pogo transposable element with KRAB domain [Source:MGI Symbol;Acc:MGI:1918842])

HSP 1 Score: 82.4185 bits (202), Expect = 5.916e-17
Identity = 62/237 (26.16%), Postives = 111/237 (46.84%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + L +   EK+ + +  +   + T   E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  217 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLAEDLTEKLVTYQQSVLALRRTHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPILVKTPGREKLRITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 453

[Close]

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + L +   EK+ + +  +   + T   E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  217 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLAEDLTEKLVTYQQSVLALRRTHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPILVKTPGREKLRITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 453

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Pogk (pogo transposable element with KRAB domain [Source:MGI Symbol;Acc:MGI:1918842])

HSP 1 Score: 82.0333 bits (201), Expect = 6.306e-17
Identity = 62/237 (26.16%), Postives = 111/237 (46.84%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + L +   EK+ + +  +   + T   E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  205 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLAEDLTEKLVTYQQSVLALRRTHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPILVKTPGREKLRITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 441

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Pogk (pogo transposable element with KRAB domain [Source:MGI Symbol;Acc:MGI:1918842])

HSP 1 Score: 82.0333 bits (201), Expect = 6.306e-17
Identity = 62/237 (26.16%), Postives = 111/237 (46.84%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + L +   EK+ + +  +   + T   E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  205 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLAEDLTEKLVTYQQSVLALRRTHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPILVKTPGREKLRITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 441

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Pogz (pogo transposable element with ZNF domain [Source:MGI Symbol;Acc:MGI:2442117])

HSP 1 Score: 47.7506 bits (112), Expect = 4.409e-6
Identity = 44/157 (28.03%), Postives = 75/157 (47.77%), Query Frame = 3

Query:  231 ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKI---TVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFK 671
            E + +L +WVL  ++  + V+   +  KA KI        F  + +W   FM R+ L+  A  +V+ +LP+   E  A L +   Q++I    + LS I +IDE+ +  D     ++D       ++G TG   CD  +VL +  DG     +V F+
Sbjct:  969 EAEEKLAEWVLIQREQQLPVNEETLFQKATKIGRSLE-GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKHVAEN-AGLFIEFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVG-TGEPWCD--VVLAILADGTVLPTLVFFR 1120

HSP 2 Score: 21.557 bits (44), Expect = 4.409e-6
Identity = 7/18 (38.89%), Postives = 10/18 (55.56%), Query Frame = 1

Query:  733 GWMDEQIFGEWLTEAWGK 786
            G+ D++I   W T  W K
Sbjct: 1141 GYSDDEIMELWSTRVWKK 1158

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9P215|POGK_HUMAN (Pogo transposable element with KRAB domain OS=Homo sapiens OX=9606 GN=POGK PE=1 SV=2)

HSP 1 Score: 86.2705 bits (212), Expect = 2.100e-17
Identity = 62/237 (26.16%), Postives = 112/237 (47.26%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLK--LYLEQKKITVELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + LP+   EK+ + +  +   ++    E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  198 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 434

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q80TC5|POGK_MOUSE (Pogo transposable element with KRAB domain OS=Mus musculus OX=10090 GN=Pogk PE=2 SV=2)

HSP 1 Score: 82.4185 bits (202), Expect = 4.262e-16
Identity = 62/237 (26.16%), Postives = 111/237 (46.84%), Query Frame = 3

Query:   45 KCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLE-YWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIA--NFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVK 719
            + Y A  +L +V +A+   N    + F V E  VR+WRK +  L+     +RA+R      +  +   + ++V   +     ++  A+ +KA +IA E  I    F  +  WC   M+R  LS+R    V + L +   EK+ + +  +   + T   E++ + + DE P+  ++P+ +T D+ G       T G EK   T +L V  DG K  P +I +   I   K  +G+ ++
Sbjct:  198 RSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQLQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPEKGFKASLGWCRRMMRRYDLSLRHKVPVPQHLAEDLTEKLVTYQQSVLALRRTHDYEVAQMGNADETPICLEVPSRVTVDNQGEKPILVKTPGREKLRITAMLGVLADGRKLPPYIILRGTYIPPGKFPSGMEIR 434

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7Z3K3|POGZ_HUMAN (Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2)

HSP 1 Score: 51.2174 bits (121), Expect = 2.695e-6
Identity = 47/176 (26.70%), Postives = 83/176 (47.16%), Query Frame = 3

Query:  231 ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKI---TVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNE 728
            E + +L +WVL  ++  + V+   +  KA KI        F  + +W   FM R+ L+  A  +V+ +LP+   E  A L +   Q++I    + LS I +IDE+ +  D     ++D       ++G TG   CD  +VL +  DG     +V ++    Q   + + IL++  E
Sbjct: 1026 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLE-GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAEN-AGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVG-TGEPWCD--VVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKE 1196

HSP 2 Score: 21.557 bits (44), Expect = 2.695e-6
Identity = 7/18 (38.89%), Postives = 10/18 (55.56%), Query Frame = 1

Query:  733 GWMDEQIFGEWLTEAWGK 786
            G+ D++I   W T  W K
Sbjct: 1198 GYSDDEIMELWSTRVWQK 1215

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A2G9UMS9 (DDE superfamily endonuclease OS=Teladorsagia circumcincta OX=45464 GN=TELCIR_07348 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 3.006e-55
Identity = 101/241 (41.91%), Postives = 145/241 (60.17%), Query Frame = 3

Query:   33 MTREKCYSAKMELEIVSFAKVDGNRAVCRHFEV-DETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKITVELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
            M +   Y+AK ++ ++ +A   G      H+ + D+  +R W+K+E  +++MP TKRA R   E WPEL+ EL  WV   +     VST+ I  +A+KIA   ++ +F     WCHSFM+R +L++R  TSV +SLP  WE+KVA   L+ ++    +    I ++DEVP++FDMPA  T D       SI TTGAEK +FT+VLCV  DG KC PMVIFKR T+ K      ++VK N+K
Sbjct:    4 MNKRLSYTAKFKVSVIDYANKHGVVEAAEHYGIKDKGMIRRWKKAENKIREMPSTKRANRGKREAWPELENELSTWVRSERNKGAQVSTIRIIREARKIARSLQLDDFLGTPHWCHSFMERKNLTVRRATSVGQSLPLDWEKKVADYHLFFQRATAGISQKDIGNMDEVPVAFDMPAARTVDIRGTQNVSIVTTGAEKANFTVVLCVLADGRKCQPMVIFKRKTLPKGPFHGNVIVKANDK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A0G2L218 (HTH CENPB-type domain-containing protein OS=Danio rerio OX=7955 PE=4 SV=1)

HSP 1 Score: 190.66 bits (483), Expect = 5.570e-54
Identity = 98/241 (40.66%), Postives = 151/241 (62.66%), Query Frame = 3

Query:   39 REKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
            +   Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   GI++K N+K
Sbjct:    5 KRHAYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCSN-KITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGIIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A0G2KDY1 (HTH CENPB-type domain-containing protein OS=Danio rerio OX=7955 PE=4 SV=1)

HSP 1 Score: 189.889 bits (481), Expect = 1.021e-53
Identity = 97/241 (40.25%), Postives = 151/241 (62.66%), Query Frame = 3

Query:   39 REKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
            +   Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   G+++K N+K
Sbjct:    5 KRHAYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCSN-KITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGVIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A0G2KPX7 (HTH CENPB-type domain-containing protein OS=Danio rerio OX=7955 PE=4 SV=2)

HSP 1 Score: 189.889 bits (481), Expect = 2.209e-53
Identity = 97/238 (40.76%), Postives = 150/238 (63.03%), Query Frame = 3

Query:   48 CYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT---VELSHISSIDEVPMSFDMPANMTND-------SIGTTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
             Y A+ +L+ +S+A V+GNRA  + F+++E+ VR WRK E  L+++  TK+++R     WP+L+ +L+ W+++ +     VST+ I ++A KIA +  I +F     WC  FMKR  LSIRA T+V++ LP  ++EK+   + Y    KIT   ++  HI+++DEVP++FD+P N T +       SI TTG EK  FT+VL    DG K  PMVIFKR T+ K+K   G+++K N+K
Sbjct:    8 AYEAQFKLQAISYAVVNGNRAAAKQFQINESMVRKWRKQENELRQVKKTKQSFRGNKARWPQLEDQLEQWIIEQRTAGRSVSTVTIRLRATKIAQDMGIEHFQGGPSWCFRFMKRRHLSIRARTTVAQQLPADYKEKLDIFRTYCS-NKITDKKIQPKHITNMDEVPLTFDIPVNHTVEKKGASTVSIRTTGHEKSAFTVVLGCHGDGQKLPPMVIFKRKTLPKEKFPAGVIIKANQK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A2I4CL25 (pogo transposable element with KRAB domain OS=Austrofundulus limnaeus OX=52670 GN=pogk PE=4 SV=1)

HSP 1 Score: 187.193 bits (474), Expect = 2.179e-52
Identity = 99/239 (41.42%), Postives = 145/239 (60.67%), Query Frame = 3

Query:   48 CYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLY----LEQKKITVELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILVKVNEK 731
             Y+A+ +L+ +S A   GNRA  R F ++E+ VR WRK E  L+++  TK+++R     WP+L+ +LK WV++ +  +  VST+ I +KA  +A E  I +F     WC  FMKR +LSI   T+VS+ LP  ++EK+A+ + Y    + +KKI  E  HI ++DEVP++FD+P N T D  G       TTG EK  FT+VL    DG K  PMVIFKR T+ K+    G+++K N K
Sbjct:    8 AYNAEFKLKAISHAVEHGNRAAAREFNINESMVRKWRKQEDELRQVKKTKQSFRGNKARWPQLEDKLKQWVVEQRAASRSVSTITIRLKATALARELNINDFRGGPSWCFRFMKRRNLSIHTRTTVSQQLPADYQEKLANFRTYCRNKITEKKIRPE--HIINMDEVPLTFDIPVNRTVDKTGARTVNVRTTGNEKSSFTVVLACQADGQKLPPMVIFKRKTLPKENFPAGVVIKANSK 244

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000030675.1 (zinc finger protein 37 [Source:NCBI gene;Acc:101161026])

HSP 1 Score: 83.1889 bits (204), Expect = 2.309e-17
Identity = 62/234 (26.50%), Postives = 105/234 (44.87%), Query Frame = 3

Query:   33 MTREKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRNWRKS-----EIVLKKMPLTKRAWRSGLEYWP-ELKAELKDWVLDTKKTNIGVSTLAIHIKAKKI------AVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKIT--VELSHISSIDEVPMSFDMPANMTNDSIGT-------TGAEKCDFTIVLCVTVDGGKCTPMVIFK 671
            M +++ +    +L  V++AK        RHF VD   +R WRK      + + +K   +KR    G +    EL+  +  W+ + ++    VS   I +KAKKI         +R   F  +  W   FMKR+ L +R  T+ ++  P     ++ S    +  K+    +E   I ++DE    FDMP   T +  G+       +G EK  FT+ L    +G K  P+++F+
Sbjct:    1 MAKKRSFDLAFKLRAVAYAKEHSGEESARHFGVDSKRIREWRKQMGDMEKTIAEKGATSKRLRGGGAKKASDELENLVLTWITEQRRKGGRVSRKMIRMKAKKIFDKEIDEASKRKETFTASSGWLDKFMKRHQLLLRRKTAPAQKDPDQVVHRLVSFVTSVANKRTADGIEDGEIIAMDETSAWFDMPGPTTAEPAGSRSDVMNASGHEKSHFTVTLAAKANGAKLKPLIVFR 234

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000031681.1 (SMESG000031681.1)

HSP 1 Score: 203.371 bits (516), Expect = 1.715e-65
Identity = 101/152 (66.45%), Postives = 115/152 (75.66%), Query Frame = 3

Query:  108 AVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKITVELSHISSIDEVPMSFDMPAN 563
            A  RH+EVDE C+RNWRKSE  LKK+  TKRA R G+EYW ++ AELK+ VLD KK   GVSTLAI IK  +IA ER I NFG N K  HSFMKRNSLSIRAVTSV +SLPQ WE+KV S K+YLEQKK   E SHI S+D+VP+ FDMP N
Sbjct:    2 AAGRHYEVDEKCIRNWRKSETALKKISPTKRARRRGMEYWLKIDAELKECVLDIKKAKRGVSTLAIRIKVNQIAFERNITNFGGNSKCYHSFMKRNSLSIRAVTSVGQSLPQDWEDKVTSFKIYLEQKKSDFEFSHICSMDKVPVRFDMPVN 153

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000040582.1 (SMESG000040582.1)

HSP 1 Score: 105.145 bits (261), Expect = 2.705e-26
Identity = 68/218 (31.19%), Postives = 109/218 (50.00%), Query Frame = 3

Query:   39 REKCYSAKMELEIVSFAKVDGN-RAVCRHFEVDETCVRNWRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKITVELSHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIF 668
            + + +S+  + EI+  A+  GN R V R + ++ET +R W   E V+K     +R+ R G   +PEL+ +L +W+L  ++  + VS + IH++A+ IA E +I     + +W  +FMK  ++ +R  T+ S          +A LK  L         + I + DEV +  DM    T ++ G       T G EK  FT+ LCV  DG K  P VI 
Sbjct:   12 QRRSFSSAKKKEIIELARQLGNIREVARRYNINETVIRRWIAQESVIKAKNPNRRSLRGGNARYPELETKLHEWILIQRERELQVSVVRIHLQAQVIAKEMKIEGLAASSQWTDNFMKCKNICVRGTTTKS---------TIADLKKDLPD-------NQIGNFDEVSIQCDMTLGYTVETKGANEVRIKTKGHEKKRFTVNLCVLKDGTKLPPFVIL 213

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000052069.1 (SMESG000052069.1)

HSP 1 Score: 92.0485 bits (227), Expect = 3.812e-22
Identity = 60/187 (32.09%), Postives = 94/187 (50.27%), Query Frame = 3

Query:  183 MPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKITVEL--SHISSIDEVPMSFDMPANMTNDSIG-------TTGAEKCDFTIVLCVTVDGGKCTPMVIFKR*TIQKKKLSNGILV 716
            M   +R+ R G   +PEL+ +L +W+L  ++  + VS   I ++A+ IA E +I  F  + +   +FMKR ++ +R  T   + LP+ WE ++A        +    +L  + I + DEV +  DMP   T ++ G       TTG EK  FT+ LCV  DG K  P VI     IQ+    N  L+
Sbjct:    1 MNPNRRSLRGGNARYPELETKLHEWILIQRERELQVSVFRIRLQAQVIAKEMKIEGFAASSQLTDNFMKRKNICVRR-TITKQQLPKDWEFQMAKF------RNTIADLLDNQIGNFDEVSVQCDMPLGYTVETKGTNEVRIKTTGHEKKRFTVNLCVLKDGTKLPPFVILGTRNIQRLSFLNQSLL 180

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000055010.1 (SMESG000055010.1)

HSP 1 Score: 85.1149 bits (209), Expect = 3.436e-20
Identity = 55/136 (40.44%), Postives = 76/136 (55.88%), Query Frame = 3

Query:  183 MPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVER-----RIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVASLKLYLEQKKITVELSHISSIDEVPMSFDMPANMTND 575
            M   KRA R   E+WPEL++ LKDWVL  +     VS L I +KA+++A         I NF  +  WC  FM+R+ LSIRAVTSV ++LP+ W+EK               EL+ I S  EVP + D+ +N+ +D
Sbjct:    1 MKPIKRARRFRKEFWPELESVLKDWVLSERLNGSRVSALKICLKAQELAKNLFQNSVNIENFKSSITWCIRFMRRHRLSIRAVTSVGQNLPEDWKEKCV----------FDEELTEIESDLEVPENLDL-SNLIDD 125

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000052241.1 (SMESG000052241.1)

HSP 1 Score: 56.6102 bits (135), Expect = 1.022e-8
Identity = 30/95 (31.58%), Postives = 56/95 (58.95%), Query Frame = 3

Query:  183 MPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLAIHIKAKKIAVERRIANFG*NRKWCHSFMKRNSLSIRAVTSVSKSLPQGWEEKVAS 467
            M   +R+ R G   +P+L+ +L +W+L  ++  + VS + I + A+ IA E +I  F  + KW  +FMKR ++ +R  T+  + L + WE ++A+
Sbjct:    1 MNPNQRSLRGGNARYPKLETKLHEWILIQRERELQVSVVRIRLHAQVIAKEIKIEGFATSSKWTDNFMKRKNICVRR-TTTKQQLSKDWEFQMAN 94

The following BLAST results are available for this feature:

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Celegans
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Fly
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Cavefish
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Yeast
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
POGK	4.372e-18	26.16	pogo transposable element derived with KRAB domain...	[more]
POGK	4.372e-18	26.16	pogo transposable element derived with KRAB domain...	[more]
POGZ	6.268e-7	26.70	pogo transposable element derived with ZNF domain ...	[more]
POGZ	6.276e-7	26.70	pogo transposable element derived with ZNF domain ...	[more]
POGZ	6.277e-7	26.70	pogo transposable element derived with ZNF domain ...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CR352209.1	2.490e-57	40.66	pep chromosome:GRCz11:24:26088143:26089609:1 gene:...	[more]
BX914205.2	4.564e-57	40.25	pep chromosome:GRCz11:4:64121772:64123545:-1 gene:...	[more]
CR354398.1	9.872e-57	40.76	pep chromosome:GRCz11:7:64150332:64152087:-1 gene:...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pogk	5.916e-17	26.16	pogo transposable element with KRAB domain [Source...	[more]
Pogk	5.916e-17	26.16	pogo transposable element with KRAB domain [Source...	[more]
Pogk	6.306e-17	26.16	pogo transposable element with KRAB domain [Source...	[more]
Pogk	6.306e-17	26.16	pogo transposable element with KRAB domain [Source...	[more]
Pogz	4.409e-6	28.03	pogo transposable element with ZNF domain [Source:...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|Q9P215\|POGK_HUMAN	2.100e-17	26.16	Pogo transposable element with KRAB domain OS=Homo...	[more]
sp\|Q80TC5\|POGK_MOUSE	4.262e-16	26.16	Pogo transposable element with KRAB domain OS=Mus ...	[more]
sp\|Q7Z3K3\|POGZ_HUMAN	2.695e-6	26.70	Pogo transposable element with ZNF domain OS=Homo ...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2G9UMS9	3.006e-55	41.91	DDE superfamily endonuclease OS=Teladorsagia circu...	[more]
A0A0G2L218	5.570e-54	40.66	HTH CENPB-type domain-containing protein OS=Danio ...	[more]
A0A0G2KDY1	1.021e-53	40.25	HTH CENPB-type domain-containing protein OS=Danio ...	[more]
A0A0G2KPX7	2.209e-53	40.76	HTH CENPB-type domain-containing protein OS=Danio ...	[more]
A0A2I4CL25	2.179e-52	41.42	pogo transposable element with KRAB domain OS=Aust...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSORLT00000030675.1	2.309e-17	26.50	zinc finger protein 37 [Source:NCBI gene;Acc:10116...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000031681.1	1.715e-65	66.45	SMESG000031681.1	[more]
SMESG000040582.1	2.705e-26	31.19	SMESG000040582.1	[more]
SMESG000052069.1	3.812e-22	32.09	SMESG000052069.1	[more]
SMESG000055010.1	3.436e-20	40.44	SMESG000055010.1	[more]
SMESG000052241.1	1.022e-8	31.58	SMESG000052241.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30001899 ID=SMED30001899|Name=HTH CENPB-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=932bp
CTGCTATCCAACCAAGAATATCAACGTTGAAAATGACAAGAGAGAAATGT
TATTCTGCTAAAATGGAACTGGAGATTGTTTCATTTGCTAAAGTTGATGG
TAATAGGGCGGTATGTCGTCATTTTGAAGTCGACGAAACGTGTGTCCGGA
ATTGGAGAAAATCAGAGATAGTTTTGAAGAAGATGCCGCTAACTAAGCGT
GCATGGAGAAGTGGGCTGGAATATTGGCCAGAACTAAAGGCTGAACTTAA
GGACTGGGTTCTAGACACTAAAAAGACGAACATAGGTGTCTCAACTCTTG
CCATTCACATAAAAGCCAAGAAAATTGCGGTTGAAAGAAGAATTGCTAAT
TTTGGTTGAAATCGCAAATGGTGCCACAGCTTTATGAAGCGCAATAGCTT
ATCGATAAGAGCTGTAACTTCAGTTAGCAAGAGTTTGCCTCAAGGCTGGG
AGGAAAAGGTAGCAAGTTTAAAGCTTTATTTAGAACAGAAAAAGATTACT
GTTGAGTTGTCTCACATAAGCAGCATAGATGAAGTGCCAATGAGCTTTGA
CATGCCAGCCAATATGACAAATGATTCTATTGGAACAACAGGCGCTGAAA
AGTGTGATTTCACCATTGTATTATGTGTCACTGTTGATGGAGGAAAGTGC
ACACCAATGGTTATTTTCAAGCGATAAACAATACAAAAGAAGAAGCTCTC
AAATGGCATTCTTGTGAAAGTAAATGAGAAGAGGATGGATGGATGAGCAG
ATATTTGGCGAGTGGTTAACTGAAGCCTGGGGAAAGTGGAAAAGCAAAAG
GTGATTTAACATAAAATCCGTTTTAAAATAACTCAGTGAGACGCCATCTG
ACGGAAAACGCTAAGAAAGAAATTCATAAACACAAACAACCCATGGCCAC
CCCAGGGAGGTTGACAAAGAAGCTACAACCTC

protein sequence of SMED30001899-orf-1

>SMED30001899-orf-1 ID=SMED30001899-orf-1|Name=SMED30001899-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=119bp
AIQPRISTLKMTREKCYSAKMELEIVSFAKVDGNRAVCRHFEVDETCVRN
WRKSEIVLKKMPLTKRAWRSGLEYWPELKAELKDWVLDTKKTNIGVSTLA
IHIKAKKIAVERRIANFG*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **molecular function**
Term	Definition
GO:0043565	sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003676	nucleic acid binding

Vocabulary: **INTERPRO**
Term	Definition
IPR009057	Homeobox-like_sf

Main menu

HTH CENPB-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

blazegraph-runner