E3 ubiquitin-protein ligase Hakai

Overview
NameE3 ubiquitin-protein ligase Hakai
Smed IDSMED30001733
Length (bp)1685
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of E3 ubiquitin-protein ligase Hakai (SMED30001733) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase Hakai (SMED30001733) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase Hakai (SMED30001733) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase Hakai (SMED30001733) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30001733

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30001733SMESG000019097.1 SmedASXL_010148SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30001733SMESG000019097.1 SmedASXL_010148SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30001733SMESG000019097.1 SmedASXL_025811SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30001733SMESG000019097.1 SmedASXL_025811SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30001733SMESG000019097.1 dd_Smed_v4_7426_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Human
Match: CBLL1 (Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:21225])

HSP 1 Score: 119.013 bits (297), Expect = 4.145e-29
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  ++ I+GE   DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   40 FWDFQINILGE-KDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTEIPERFI 171
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Human
Match: CBLL1 (Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:21225])

HSP 1 Score: 120.553 bits (301), Expect = 1.506e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  ++ I+GE   DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   90 FWDFQINILGE-KDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTEIPERFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Human
Match: CBLL1 (Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:21225])

HSP 1 Score: 120.553 bits (301), Expect = 1.549e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  ++ I+GE   DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   89 FWDFQINILGE-KDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTEIPERFI 220
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Human
Match: CBLL2 (Cbl proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:26371])

HSP 1 Score: 94.3597 bits (233), Expect = 5.477e-20
Identity = 47/107 (43.93%), Postives = 62/107 (57.94%), Query Frame = 2 
Query:  527 KVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQD---KKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKT 838
            K+ I+GE   D   HFCD C +PI IY R+IPCKH FC+ C + Y     K CPRC   V + E    G+++MC        +Q C+RTYLSQ+ L +HI  RH + 
Sbjct:   42 KINIIGE-KDDLPIHFCDKCDLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLRIEAHKRGSVFMC------SIVQQCKRTYLSQKSLQAHIKRRHKRA 141
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Fly
Match: Hakai (gene:FBgn0032812 transcript:FBtr0081264)

HSP 1 Score: 134.42 bits (337), Expect = 6.327e-35
Identity = 55/104 (52.88%), Postives = 70/104 (67.31%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W +KV ++GE + + + H CD C  PI +Y RMIPCKH+FC  C      K CPRC  KV + E+   GT++MC  GG+ +G  GCRRTYLSQRDL +HINHRH
Sbjct:  161 WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRH 264
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Fly
Match: Hakai (gene:FBgn0032812 transcript:FBtr0331246)

HSP 1 Score: 137.887 bits (346), Expect = 7.591e-35
Identity = 55/104 (52.88%), Postives = 70/104 (67.31%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W +KV ++GE + + + H CD C  PI +Y RMIPCKH+FC  C      K CPRC  KV + E+   GT++MC  GG+ +G  GCRRTYLSQRDL +HINHRH
Sbjct:  161 WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRH 264
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Fly
Match: Hakai (gene:FBgn0032812 transcript:FBtr0331245)

HSP 1 Score: 137.502 bits (345), Expect = 8.279e-35
Identity = 55/104 (52.88%), Postives = 70/104 (67.31%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W +KV ++GE + + + H CD C  PI +Y RMIPCKH+FC  C      K CPRC  KV + E+   GT++MC  GG+ +G  GCRRTYLSQRDL +HINHRH
Sbjct:  152 WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRH 255
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Fly
Match: Hakai (gene:FBgn0032812 transcript:FBtr0081263)

HSP 1 Score: 133.65 bits (335), Expect = 9.576e-35
Identity = 55/104 (52.88%), Postives = 70/104 (67.31%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W +KV ++GE + + + H CD C  PI +Y RMIPCKH+FC  C      K CPRC  KV + E+   GT++MC  GG+ +G  GCRRTYLSQRDL +HINHRH
Sbjct:  152 WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRH 255
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Zebrafish
Match: zgc:101783 (zgc:101783 [Source:ZFIN;Acc:ZDB-GENE-040912-48])

HSP 1 Score: 114.39 bits (285), Expect = 9.944e-27
Identity = 57/119 (47.90%), Postives = 73/119 (61.34%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPT 847
             W  K+ +VG +  DT  HFCD C +PI IY RMIPCKH+FC+ C   Y+   DK CP      C   V + E+C  G+++MC      + +QGC+RTYLSQRDL +HINHRH K   T
Sbjct:   87 FWDYKLNLVG-VKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAVYYEKKCDKMCPGLSLYSCTDPVQRIEQCQRGSLFMC------NIVQGCKRTYLSQRDLQAHINHRHMKASKT 198
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Zebrafish
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 106.301 bits (264), Expect = 1.758e-25
Identity = 54/112 (48.21%), Postives = 69/112 (61.61%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W  K+ +VGE   +T  HFCD C +PI  Y RMIPCKH+FC+ C   ++   DK CP      C   V + E+C  G++YMC        +QGC+RTYLSQRDL +HINHRH
Sbjct:   89 WDYKLNLVGE-KDETPVHFCDKCGLPIKTYGRMIPCKHVFCYDCALHHERKGDKMCPGLNMYSCTDPVQRIEQCQRGSLYMCSI------VQGCKRTYLSQRDLQAHINHRH 193
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Zebrafish
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 109.383 bits (272), Expect = 4.317e-25
Identity = 54/112 (48.21%), Postives = 69/112 (61.61%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W  K+ +VGE   +T  HFCD C +PI  Y RMIPCKH+FC+ C   ++   DK CP      C   V + E+C  G++YMC        +QGC+RTYLSQRDL +HINHRH
Sbjct:   82 WDYKLNLVGE-KDETPVHFCDKCGLPIKTYGRMIPCKHVFCYDCALHHERKGDKMCPGLNMYSCTDPVQRIEQCQRGSLYMCSI------VQGCKRTYLSQRDLQAHINHRH 186
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Zebrafish
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 79.7221 bits (195), Expect = 1.164e-15
Identity = 39/82 (47.56%), Postives = 51/82 (62.20%), Query Frame = 2 
Query:  614 MIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK 835
            MIPCKH+FC+ C   ++   DK CP      C   V + E+C  G++YMC        +QGC+RTYLSQRDL +HINHRH +
Sbjct:    1 MIPCKHVFCYDCALHHERKGDKMCPGLNMYSCTDPVQRIEQCQRGSLYMCSI------VQGCKRTYLSQRDLQAHINHRHMR 76
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:100170461])

HSP 1 Score: 122.094 bits (305), Expect = 4.680e-29
Identity = 66/143 (46.15%), Postives = 86/143 (60.14%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ ++GE  +DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C+  V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + T PT     P    I P P++ P   +P  FI
Sbjct:   90 FWDFKLNLIGE-KEDTPIHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGCNDPVQRIEQCARGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRATKPT---ARPQPEPIHP-PLAPPQAEIPDRFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:100170461])

HSP 1 Score: 121.709 bits (304), Expect = 5.048e-29
Identity = 66/143 (46.15%), Postives = 86/143 (60.14%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ ++GE  +DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C+  V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + T PT     P    I P P++ P   +P  FI
Sbjct:   91 FWDFKLNLIGE-KEDTPIHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGCNDPVQRIEQCARGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRATKPT---ARPQPEPIHP-PLAPPQAEIPDRFI 222
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:100170461])

HSP 1 Score: 121.709 bits (304), Expect = 6.088e-29
Identity = 66/143 (46.15%), Postives = 86/143 (60.14%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ ++GE  +DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C+  V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + T PT     P    I P P++ P   +P  FI
Sbjct:   90 FWDFKLNLIGE-KEDTPIHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGCNDPVQRIEQCARGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRATKPT---ARPQPEPIHP-PLAPPQAEIPDRFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:100170461])

HSP 1 Score: 112.079 bits (279), Expect = 7.100e-26
Identity = 66/157 (42.04%), Postives = 86/157 (54.78%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCP--------------RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ ++GE  +DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP               C+  V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + T PT     P    I P P++ P   +P  FI
Sbjct:   43 FWDFKLNLIGE-KEDTPIHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGTLVEESTDTFKRMSCNDPVQRIEQCARGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRATKPT---ARPQPEPIHP-PLAPPQAEIPDRFI 188
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:NCBI gene;Acc:100170461])

HSP 1 Score: 84.7297 bits (208), Expect = 8.030e-17
Identity = 54/141 (38.30%), Postives = 74/141 (52.48%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPR-CDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ ++GE  +DT  HFCD C +PI IY RM+                 +C   C+  V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + T PT     P    I P P++ P   +P  FI
Sbjct:   86 FWDFKLNLIGE-KEDTPIHFCDKCGLPIKIYGRMV---------------GHRCEYYCNDPVQRIEQCARGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRATKPT---ARPQPEPIHP-PLAPPQAEIPDRFI 200
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Match: Cbll1 (Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842])

HSP 1 Score: 119.398 bits (298), Expect = 3.096e-29
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   86 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 217
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Match: Cbll1 (Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842])

HSP 1 Score: 120.553 bits (301), Expect = 4.979e-29
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   90 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Match: Cbll1 (Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842])

HSP 1 Score: 120.553 bits (301), Expect = 1.024e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   90 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Match: Cbll1 (Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842])

HSP 1 Score: 120.553 bits (301), Expect = 1.073e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   89 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 220
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Match: Cbll1 (Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842])

HSP 1 Score: 120.553 bits (301), Expect = 1.134e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   87 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 218
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Match: sp|M9PBE2|HAKAI_DROME (E3 ubiquitin-protein ligase Hakai OS=Drosophila melanogaster OX=7227 GN=Hakai PE=1 SV=1)

HSP 1 Score: 137.887 bits (346), Expect = 7.609e-34
Identity = 55/104 (52.88%), Postives = 70/104 (67.31%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRH 829
            W +KV ++GE + + + H CD C  PI +Y RMIPCKH+FC  C      K CPRC  KV + E+   GT++MC  GG+ +G  GCRRTYLSQRDL +HINHRH
Sbjct:  161 WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRH 264
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Match: sp|Q9JIY2|HAKAI_MOUSE (E3 ubiquitin-protein ligase Hakai OS=Mus musculus OX=10090 GN=Cbll1 PE=1 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 7.166e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  K+ I+GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   90 FWDFKINILGE-KDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTDIPDRFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Match: sp|Q75N03|HAKAI_HUMAN (E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 7.234e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  ++ I+GE   DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   90 FWDFQINILGE-KDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTEIPERFI 221
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Match: sp|Q4R7I8|HAKAI_MACFA (E3 ubiquitin-protein ligase Hakai OS=Macaca fascicularis OX=9541 GN=CBLL1 PE=2 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 7.722e-28
Identity = 64/142 (45.07%), Postives = 84/142 (59.15%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFI 931
             W  ++ I+GE   DT  HFCD C +PI IY RMIPCKH+FC+ C     K  DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G     T  S  ++ P P++ P   +P  FI
Sbjct:   89 FWDFQINILGE-KDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKP--VTRASLENVHP-PIAPPPTEIPERFI 220
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Match: sp|Q5ZHZ4|HAKAI_CHICK (E3 ubiquitin-protein ligase Hakai OS=Gallus gallus OX=9031 GN=CBLL1 PE=2 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 2.513e-27
Identity = 55/112 (49.11%), Postives = 73/112 (65.18%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTG 841
             W  K+ ++GE   DT  HFCD C +PI +Y RMIPCKH+FC+ C     K  DK CP C++ V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH + G
Sbjct:   90 FWDYKINLLGE-KDDTPVHFCDKCGLPIKMYGRMIPCKHVFCYDCAILHEKKGDKMCPGCNEPVQRIEQCVRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAG 194
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Match: A0A1S3HMX2 (E3 ubiquitin-protein ligase Hakai OS=Lingula unguis OX=7574 GN=LOC106156615 PE=4 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 1.127e-33
Identity = 63/120 (52.50%), Postives = 82/120 (68.33%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTG--PTPNQTVPSQ 871
            W +KV ++GE + D + H CD C +PI IY RMIPCKH+FCF C  K  DK C RCD  V + E+   G++++C  GG  HG+ GCRRTYLSQRDL +H+NHRH + G  P+P+Q  P Q
Sbjct:   89 WNHKVNLIGEKVVDPLIHCCDKCDLPILIYGRMIPCKHVFCFDCAKK-TDKNCARCDDPVQRIEQSALGSVFVCTFGGTKHGVSGCRRTYLSQRDLQAHVNHRHLREGQQPSPHQAPPVQ 207
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Match: A0A182W577 (RING-type domain-containing protein OS=Anopheles minimus OX=112268 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 4.601e-33
Identity = 65/134 (48.51%), Postives = 85/134 (63.43%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLP 919
            W +KV ++GE + + + + CD C  PI IY RMIPCKH+FC  C      K CPRC++KV + E+   GT++MC  GG  +G  GCRRTYLSQRDL +HINHRH  T P P Q    Q +I PL + +P   +P
Sbjct:  135 WNHKVNLIGEKVLNPMIYCCDRCDNPILIYGRMIPCKHVFCLRCARSETFKVCPRCNEKVVRVEQTRLGTVFMCTHGGTRYGNTGCRRTYLSQRDLQAHINHRH-VTNPAPAQ----QTTIQPLVIPSPQQTIP 263
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Match: A0A482VUB4 (E3 ubiquitin-protein ligase Hakai OS=Asbolus verrucosus OX=1661398 GN=BDFB_005408 PE=4 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 1.609e-32
Identity = 64/127 (50.39%), Postives = 82/127 (64.57%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVS 898
            W +KV ++GE + + + H CD C  PI IY RMIPCKH+FC  CG K + K+CPRC  KV++ E+   GT++MC  GG  +G  GCRRTYLSQRDL +HINHRH       N   P + S+ P  VS
Sbjct:  100 WTHKVNLIGEKVLNPMIHCCDKCLKPILIYGRMIPCKHVFCLSCG-KQEQKQCPRCLDKVSRVEQTGLGTVFMCTHGGTRYGSSGCRRTYLSQRDLQAHINHRH-----VSNTIQPMEVSVEPERVS 220
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Match: D7EHU7 (RING-type domain-containing protein OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC002259 PE=4 SV=1)

HSP 1 Score: 137.887 bits (346), Expect = 2.492e-32
Identity = 60/118 (50.85%), Postives = 79/118 (66.95%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQ 871
            W +KV ++GE + + + H CD C  PI IY RMIPCKH+FC  CG K + K+CPRC +KV++ E+   GT++MC  GG  +G  GCRRTYLS RDL +HINHRH      P + VP +
Sbjct:  100 WSHKVNLIGEKVLNPMIHCCDKCLKPILIYGRMIPCKHVFCLSCG-KQEQKQCPRCLEKVSRVEQTGLGTVFMCTHGGTRYGSSGCRRTYLSHRDLQAHINHRHVSNTIQPMEVVPVE 216
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Match: A0A084WCD7 (RING-type domain-containing protein OS=Anopheles sinensis OX=74873 GN=ZHAS_00015937 PE=4 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 2.801e-32
Identity = 58/113 (51.33%), Postives = 73/113 (64.60%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQ 856
            W +KV ++GE + + + + CD C  PI IY RMIPCKH+FC  C      K CPRC +KV + E+   GT++MC  GG  +G  GCRRTYLSQRDL +HINHRH    P P Q
Sbjct:  150 WNHKVNLIGEKVLNPMIYCCDQCDKPILIYGRMIPCKHVFCLSCARSDTLKVCPRCKEKVVRVEQTGLGTVFMCTHGGTRYGSTGCRRTYLSQRDLQAHINHRHVTNPPVPMQ 262
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Cavefish
Match: ENSAMXT00000009654.2 (E3 ubiquitin-protein ligase Hakai-like [Source:NCBI gene;Acc:103041099])

HSP 1 Score: 117.857 bits (294), Expect = 7.812e-28
Identity = 64/153 (41.83%), Postives = 87/153 (56.86%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTG--------PTPNQTVPSQCSIMPLP-VSNPLNMLPP 922
             W  K+ +VGE   DT  HFCD C +PI +Y RMIPCKH+FC+ C   Y+   DK CP      C   V + E+C  G+++MC        +QGC+RTYLSQRDL +HINHRH ++G        P+P    P +  + P P +S    ++PP
Sbjct:  124 FWDYKLNLVGE-KDDTPIHFCDKCGLPIKLYGRMIPCKHVFCYDCAVLYEKKNDKMCPGLSMYSCTDPVQRIEQCQRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRSGKPGGSRPEPSPASDPPDRFRLPPPPHLSKGHPLIPP 269
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Cavefish
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 112.464 bits (280), Expect = 4.083e-26
Identity = 51/109 (46.79%), Postives = 70/109 (64.22%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK 835
            W  K+ ++GE   +T  HFCD C +PI  Y RMIPCKH+FC+ C   ++   DK CP C   V + E+C  G+++MC        +QGC+RTYLSQRDL +H+NHRH +
Sbjct:   82 WDYKLNLIGE-RDETPVHFCDKCGLPIKSYGRMIPCKHVFCYDCALLHERKGDKMCPGCTDPVQRIEQCQRGSLFMCSI------VQGCKRTYLSQRDLQAHVNHRHMR 183
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Cavefish
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 106.686 bits (265), Expect = 3.125e-24
Identity = 51/114 (44.74%), Postives = 70/114 (61.40%), Query Frame = 2 
Query:  518 WKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK 835
            W  K+ ++GE   +T  HFCD C +PI  Y RMIPCKH+FC+ C   ++   DK CP      C   V + E+C  G+++MC        +QGC+RTYLSQRDL +H+NHRH +
Sbjct:   70 WDYKLNLIGE-RDETPVHFCDKCGLPIKSYGRMIPCKHVFCYDCALLHERKGDKMCPGLTMYSCTDPVQRIEQCQRGSLFMCSI------VQGCKRTYLSQRDLQAHVNHRHMR 176
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Sea Lamprey
Match: cbll1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-040426-691])

HSP 1 Score: 113.235 bits (282), Expect = 3.722e-27
Identity = 62/147 (42.18%), Postives = 87/147 (59.18%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTV-FHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ---DKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNK-TGPTPNQTVPSQCSIM-PLPVSNPLNMLPPNFINS 937
            +W  K+ I G+  KD +  HFCD C +PI +Y RMIPCKH+FCF C S ++   DK CP C  +V + E+C  GT+++C      + + GC+RTYLSQRDL +HINHRH + T P     V  +  ++ P P  +     PPN  + 
Sbjct:   88 IWDCKINIFGK--KDEIPVHFCDKCGLPIKVYGRMIPCKHVFCFDCASLHEQRGDKSCPGCVDQVQRIEQCLRGTVFLC------NVVSGCKRTYLSQRDLQAHINHRHVRHTKPQQRPVVSEEHHVVAPGPGVHDHYQKPPNIAHD 226
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Medaka
Match: cbll1 (Cbl proto-oncogene like 1 [Source:NCBI gene;Acc:105357056])

HSP 1 Score: 104.76 bits (260), Expect = 1.439e-23
Identity = 53/117 (45.30%), Postives = 71/117 (60.68%), Query Frame = 2 
Query:  515 LWKNKVYIVGEIMKDTV-FHFCDTCQMPIFIYCRMIPCKHIFCFPCG---SKYQDKKCP-----RCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKT 838
            LW  K+ ++GE  +D V  HFCD C +PI +Y RMIPCKH+FC+ C     K  +K CP      C   V + E+C  G++YMC        + GC+RTYLSQRDL +H+NHRH + 
Sbjct:   92 LWDCKLNLIGE--RDEVPIHFCDKCGLPIQLYGRMIPCKHVFCYDCALLHEKKGEKMCPGLSLYNCTDPVQRIEQCQRGSLYMCSI------VPGCKRTYLSQRDLQAHVNHRHMRA 200
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Planmine SMEST
Match: SMESG000019097.1 (SMESG000019097.1)

HSP 1 Score: 501.13 bits (1289), Expect = 1.799e-173
Identity = 488/488 (100.00%), Postives = 488/488 (100.00%), Query Frame = 2 
Query:   65 MEDIKTKTNSYNKRSHRSKSSYSETDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPGNLTXXXXXXXXXXXXXXXXXXXXXYDGKNSRANSITKSRXXXXXXXXXXXXXXXXXXXXELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNXXXXXXXXXXXXXXXXXXXXXXXXXXAXXXXXXXXXXXXXXGXXXXXXXXXXXXXXXXXXXXXFGLQMPHLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGIXXXXXXXXXXXXXXXAGRQFHDLQRQFQRPMK 1528
            MEDIKTKTNSYNKRSHRSKSSYSETDEKKSKRNRSNSYRNESEEEKSSRSKHRHDSRSISRSRSYTSVSRSNESSYNRSYRSRSMSRSPGNLTRHRKSKHHRRSRSWSHNSSHSYDGKNSRANSITKSRSPRHSKDKKKTKDPRDKSKRELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNQFQQHHLQSLLQQQQMPLNQLQTQQLASMSHTPPTHMMPPMGNMMAPNQQQINPNQNQMPNQNFGLQMPHLNMMPCNMNQNNMPMINQNSQNVNVGSLNNPNNSSVSQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGISQQQQQQQQQQQQSQAGRQFHDLQRQFQRPMK
Sbjct:    1 MEDIKTKTNSYNKRSHRSKSSYSETDEKKSKRNRSNSYRNESEEEKSSRSKHRHDSRSISRSRSYTSVSRSNESSYNRSYRSRSMSRSPGNLTRHRKSKHHRRSRSWSHNSSHSYDGKNSRANSITKSRSPRHSKDKKKTKDPRDKSKRELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNQFQQHHLQSLLQQQQMPLNQLQTQQLASMSHTPPTHMMPPMGNMMAPNQQQINPNQNQMPNQNFGLQMPHLNMMPCNMNQNNMPMINQNSQNVNVGSLNNPNNSSVSQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGISQQQQQQQQQQQQSQAGRQFHDLQRQFQRPMK 488
[Close]
BLAST of E3 ubiquitin-protein ligase Hakai vs. Planmine SMEST
Match: SMESG000019097.1 (SMESG000019097.1)

HSP 1 Score: 471.085 bits (1211), Expect = 5.332e-162
Identity = 400/400 (100.00%), Postives = 400/400 (100.00%), Query Frame = 2 
Query:  329 PGNLTXXXXXXXXXXXXXXXXXXXXXYDGKNSRANSITKSRXXXXXXXXXXXXXXXXXXXXELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNXXXXXXXXXXXXXXXXXXXXXXXXXXAXXXXXXXXXXXXXXGXXXXXXXXXXXXXXXXXXXXXFGLQMPHLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGIXXXXXXXXXXXXXXXAGRQFHDLQRQFQRPMK 1528
            PGNLTRHRKSKHHRRSRSWSHNSSHSYDGKNSRANSITKSRSPRHSKDKKKTKDPRDKSKRELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNQFQQHHLQSLLQQQQMPLNQLQTQQLASMSHTPPTHMMPPMGNMMAPNQQQINPNQNQMPNQNFGLQMPHLNMMPCNMNQNNMPMINQNSQNVNVGSLNNPNNSSVSQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGISQQQQQQQQQQQQSQAGRQFHDLQRQFQRPMK
Sbjct:   71 PGNLTRHRKSKHHRRSRSWSHNSSHSYDGKNSRANSITKSRSPRHSKDKKKTKDPRDKSKRELWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQDKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSHINHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNQFQQHHLQSLLQQQQMPLNQLQTQQLASMSHTPPTHMMPPMGNMMAPNQQQINPNQNQMPNQNFGLQMPHLNMMPCNMNQNNMPMINQNSQNVNVGSLNNPNNSSVSQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLSNLIQGISQQQQQQQQQQQQSQAGRQFHDLQRQFQRPMK 470

HSP 2 Score: 53.9138 bits (128), Expect = 2.121e-7
Identity = 26/26 (100.00%), Postives = 26/26 (100.00%), Query Frame = 2 
Query:   65 MEDIKTKTNSYNKRSHRSKSSYSETD 142
            MEDIKTKTNSYNKRSHRSKSSYSETD
Sbjct:    1 MEDIKTKTNSYNKRSHRSKSSYSETD 26
The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
CBLL14.145e-2945.07Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:... [more]
CBLL11.506e-2845.07Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:... [more]
CBLL11.549e-2845.07Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:... [more]
CBLL25.477e-2043.93Cbl proto-oncogene like 2 [Source:HGNC Symbol;Acc:... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Hakai6.327e-3552.88gene:FBgn0032812 transcript:FBtr0081264[more]
Hakai7.591e-3552.88gene:FBgn0032812 transcript:FBtr0331246[more]
Hakai8.279e-3552.88gene:FBgn0032812 transcript:FBtr0331245[more]
Hakai9.576e-3552.88gene:FBgn0032812 transcript:FBtr0081263[more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
zgc:1017839.944e-2747.90zgc:101783 [Source:ZFIN;Acc:ZDB-GENE-040912-48][more]
cbll11.758e-2548.21Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll14.317e-2548.21Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll11.164e-1547.56Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbll14.680e-2946.15Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll15.048e-2946.15Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll16.088e-2946.15Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll17.100e-2642.04Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll18.030e-1738.30Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cbll13.096e-2945.07Casitas B-lineage lymphoma-like 1 [Source:MGI Symb... [more]
Cbll14.979e-2945.07Casitas B-lineage lymphoma-like 1 [Source:MGI Symb... [more]
Cbll11.024e-2845.07Casitas B-lineage lymphoma-like 1 [Source:MGI Symb... [more]
Cbll11.073e-2845.07Casitas B-lineage lymphoma-like 1 [Source:MGI Symb... [more]
Cbll11.134e-2845.07Casitas B-lineage lymphoma-like 1 [Source:MGI Symb... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|M9PBE2|HAKAI_DROME7.609e-3452.88E3 ubiquitin-protein ligase Hakai OS=Drosophila me... [more]
sp|Q9JIY2|HAKAI_MOUSE7.166e-2845.07E3 ubiquitin-protein ligase Hakai OS=Mus musculus ... [more]
sp|Q75N03|HAKAI_HUMAN7.234e-2845.07E3 ubiquitin-protein ligase Hakai OS=Homo sapiens ... [more]
sp|Q4R7I8|HAKAI_MACFA7.722e-2845.07E3 ubiquitin-protein ligase Hakai OS=Macaca fascic... [more]
sp|Q5ZHZ4|HAKAI_CHICK2.513e-2749.11E3 ubiquitin-protein ligase Hakai OS=Gallus gallus... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3HMX21.127e-3352.50E3 ubiquitin-protein ligase Hakai OS=Lingula ungui... [more]
A0A182W5774.601e-3348.51RING-type domain-containing protein OS=Anopheles m... [more]
A0A482VUB41.609e-3250.39E3 ubiquitin-protein ligase Hakai OS=Asbolus verru... [more]
D7EHU72.492e-3250.85RING-type domain-containing protein OS=Tribolium c... [more]
A0A084WCD72.801e-3251.33RING-type domain-containing protein OS=Anopheles s... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSAMXT00000009654.27.812e-2841.83E3 ubiquitin-protein ligase Hakai-like [Source:NCB... [more]
cbll14.083e-2646.79Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
cbll13.125e-2444.74Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cbll13.722e-2742.18Cbl proto-oncogene-like 1, E3 ubiquitin protein li... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cbll11.439e-2345.30Cbl proto-oncogene like 1 [Source:NCBI gene;Acc:10... [more]
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BLAST of E3 ubiquitin-protein ligase Hakai vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000019097.11.799e-173100.00SMESG000019097.1[more]
SMESG000019097.15.332e-162100.00SMESG000019097.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001733 ID=SMED30001733|Name=E3 ubiquitin-protein ligase Hakai|organism=Schmidtea mediterranea sexual|type=transcript|length=1685bp
CTCTTAAAACCATATTTAAATTTTTTATTTATTTTTGAAAAATTTGTATT
CTATTGGTTATCTAATGGAGGACATAAAAACCAAAACTAATTCTTATAAT
AAACGAAGTCATAGGTCTAAAAGTTCTTATTCTGAAACTGATGAAAAAAA
ATCAAAAAGGAATCGATCCAATTCTTATCGGAATGAATCAGAGGAAGAAA
AGTCTTCTAGATCTAAACATCGGCATGATTCAAGATCCATAAGTCGTTCT
AGGTCTTATACATCAGTATCTCGATCGAACGAATCATCATATAATAGATC
TTATAGGTCACGGTCAATGTCTCGTAGCCCTGGTAATCTAACGAGACATC
GTAAGTCAAAGCACCATCGAAGATCCCGTTCTTGGTCTCACAATTCTTCT
CACAGCTACGATGGGAAAAACAGCAGAGCTAATAGCATAACAAAGTCTAG
ATCTCCTAGACATTCAAAAGATAAAAAGAAAACAAAGGATCCCAGAGATA
AATCAAAAAGAGAACTTTGGAAAAATAAAGTTTACATTGTTGGAGAAATA
ATGAAAGATACAGTATTTCATTTTTGTGATACTTGCCAAATGCCAATTTT
CATATATTGTCGCATGATACCCTGCAAACATATTTTTTGTTTTCCTTGTG
GATCAAAATATCAGGATAAAAAATGTCCAAGATGCGATAAGAAAGTTAAT
CAAACTGAGCGATGTAATTTTGGAACGATTTACATGTGTTATAAAGGCGG
CAATCCTCATGGAATGCAAGGATGTCGTCGCACATATTTATCCCAACGTG
ATCTAGATTCACACATTAATCACCGGCACAATAAAACCGGGCCAACACCT
AATCAAACGGTTCCCAGTCAGTGCTCAATAATGCCATTGCCGGTATCAAA
TCCTTTGAATATGCTTCCACCCAATTTTATAAACTCTTTTCCCAATCAAT
TCCAACAGCATCATCTGCAATCGTTGCTTCAACAGCAACAAATGCCTCTA
AATCAATTACAAACCCAACAATTGGCCTCTATGTCGCATACTCCACCGAC
TCACATGATGCCACCAATGGGAAATATGATGGCTCCTAATCAACAGCAAA
TCAATCCCAACCAAAACCAGATGCCCAATCAAAATTTTGGCCTTCAAATG
CCGCACCTAAACATGATGCCGTGCAATATGAATCAAAATAATATGCCTAT
GATAAATCAAAATTCACAGAATGTCAATGTTGGATCTCTTAACAACCCCA
ACAACTCTTCGGTATCCCAAATGGGGCCCAATAGCAATCTAGTGCAGACA
ACACTGTTCATGCACGGTGCTGGTCCGGCCAATGCAAATAATCCTATGAT
GATGGGAGGTTCCAATTCTGGATTTAATTCAGCGAATGCGCCACCGTTAA
TGACCCAGTTGAGCAATCTCATCCAAGGCATATCCCAGCAACAGCAGCAA
CAACAACAACAGCAACAACAGTCACAAGCTGGTAGACAATTTCATGATTT
ACAAAGACAATTTCAAAGACCAATGAAAAATCAACAACAAAATTGGTCAA
ATCAATCATCTCAAGGACAGCAAGGGCAACTTAATCATTCGTCAAATCAA
TAGTTATGTTTTCTGTAGAATAATATAATTAATTGTCTGTACACAATATT
TCACATATTAATAAATCATTTAGTTCTTCAAGATC
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protein sequence of SMED30001733-orf-1

>SMED30001733-orf-1 ID=SMED30001733-orf-1|Name=SMED30001733-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=513bp
MEDIKTKTNSYNKRSHRSKSSYSETDEKKSKRNRSNSYRNESEEEKSSRS
KHRHDSRSISRSRSYTSVSRSNESSYNRSYRSRSMSRSPGNLTRHRKSKH
HRRSRSWSHNSSHSYDGKNSRANSITKSRSPRHSKDKKKTKDPRDKSKRE
LWKNKVYIVGEIMKDTVFHFCDTCQMPIFIYCRMIPCKHIFCFPCGSKYQ
DKKCPRCDKKVNQTERCNFGTIYMCYKGGNPHGMQGCRRTYLSQRDLDSH
INHRHNKTGPTPNQTVPSQCSIMPLPVSNPLNMLPPNFINSFPNQFQQHH
LQSLLQQQQMPLNQLQTQQLASMSHTPPTHMMPPMGNMMAPNQQQINPNQ
NQMPNQNFGLQMPHLNMMPCNMNQNNMPMINQNSQNVNVGSLNNPNNSSV
SQMGPNSNLVQTTLFMHGAGPANANNPMMMGGSNSGFNSANAPPLMTQLS
NLIQGISQQQQQQQQQQQQSQAGRQFHDLQRQFQRPMKNQQQNWSNQSSQ
GQQGQLNHSSNQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0016567protein ubiquitination
Vocabulary: molecular function
TermDefinition
GO:0061630ubiquitin protein ligase activity
GO:0008270zinc ion binding
GO:0005515protein binding
GO:0003676nucleic acid binding
GO:0016874ligase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR041042Znf_Hakai
IPR040383HAKAI/CBLL2
IPR040380HAKAI-like_RING-HC
IPR013083Znf_RING/FYVE/PHD
IPR001841Znf_RING
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.30.160.640coord: 232..269
e-value: 9.3E-15
score: 55.7
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 456..512
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 110..127
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 90..108
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 61..89
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..147
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 17..52
NoneNo IPR availablePANTHERPTHR13480:SF2E3 UBIQUITIN-PROTEIN LIGASE HAKAIcoord: 151..341
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 170..213
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 168..223
e-value: 1.3E-18
score: 68.9
IPR041042Hakai, C2H2 zinc finger domainPFAMPF18408zf_Hakaicoord: 220..257
e-value: 6.1E-16
score: 57.8
IPR040383E3 ubiquitin-protein ligase HAKAI/CBLL2PANTHERPTHR13480E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATEDcoord: 151..341
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 171..208
score: 9.716
IPR040380HAKAI-like, RING finger, HC subclassCDDcd16508RING-HC_HAKAI_likecoord: 169..207
e-value: 5.58659E-17
score: 72.4099