slc18a-1

Overview
Nameslc18a-1 (AKN21536.1)
Smed IDSMED30001666
Length (bp)1678
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of slc18a-1 (SMED30001666) t-SNE clustered cells

Violin plots show distribution of expression levels for slc18a-1 (SMED30001666) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of slc18a-1 (SMED30001666) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for slc18a-1 (SMED30001666) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30001666

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30001666h1SMcG0015576 SmedASXL_004184SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30001666h1SMcG0015576 SmedASXL_074452SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30001666h1SMcG0015576 dd_Smed_v6_25183_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of slc18a-1 vs. Ensembl Human
Match: SLC18A3 (solute carrier family 18 member A3 [Source:HGNC Symbol;Acc:HGNC:10936])

HSP 1 Score: 63.5438 bits (153), Expect = 5.219e-10
Identity = 78/379 (20.58%), Postives = 150/379 (39.58%), Query Frame = 1 
Query:  349 MIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHS--IGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            ++F SK++ Q   N + G F+D+++  + LLIG G+     +++A           R L    S      G ++++  +     R R   LG  L F+S    + P +G  +    GK   F +L  + +F                                       D    L VA   S+ ++               + N  +    +++M +PY++     L   N+ +  L  T+ +WM   + A+E + G+ W   F+ +V GV L V L      L++    +   ++G    ++P    +  L + + G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF 
Sbjct:  126 VLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSR--ALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLF---------------------------------------DALLLLAVAKPFSAAAR--------------ARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFE 449
[Close]
BLAST of slc18a-1 vs. Ensembl Human
Match: SLC18A2 (solute carrier family 18 member A2 [Source:HGNC Symbol;Acc:HGNC:10935])

HSP 1 Score: 52.7582 bits (125), Expect = 1.316e-6
Identity = 42/165 (25.45%), Postives = 85/165 (51.52%), Query Frame = 1 
Query:  985 IMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++K+PY+      +   N+ +  L   LP WM   +C+ + Q G+ +    I Y+ G  +  +L   A+++ R+   ++  IIVG+ ++ +P + +   L  P  G+ F++G+++  + P+  YL D    S YGS+ ++   +  +   +G  + G IA+  GF
Sbjct:  288 LLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGIL---AHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGF 449
[Close]
BLAST of slc18a-1 vs. Ensembl Human
Match: SLC18A1 (solute carrier family 18 member A1 [Source:HGNC Symbol;Acc:HGNC:10934])

HSP 1 Score: 52.7582 bits (125), Expect = 1.392e-6
Identity = 42/168 (25.00%), Postives = 82/168 (48.81%), Query Frame = 1 
Query:  973 KFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
              + ++K+PY+      +   N+ +  L  TLP WM   +C+ + Q GL +    + Y+ G  L  +L       R+   +I  ++VG  L+ +PL+H+   L  P  G+  ++G+++  + P+  +L D    S YGS+ ++   +  +   +G  + G I +  GF
Sbjct:  292 PLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLAN--KMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGF 457
[Close]
BLAST of slc18a-1 vs. Ensembl Human
Match: SLC18A1 (solute carrier family 18 member A1 [Source:HGNC Symbol;Acc:HGNC:10934])

HSP 1 Score: 52.7582 bits (125), Expect = 1.392e-6
Identity = 42/168 (25.00%), Postives = 82/168 (48.81%), Query Frame = 1 
Query:  973 KFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
              + ++K+PY+      +   N+ +  L  TLP WM   +C+ + Q GL +    + Y+ G  L  +L       R+   +I  ++VG  L+ +PL+H+   L  P  G+  ++G+++  + P+  +L D    S YGS+ ++   +  +   +G  + G I +  GF
Sbjct:  292 PLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLAN--KMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGF 457
[Close]
BLAST of slc18a-1 vs. Ensembl Celegans
Match: unc-17 (Vesicular acetylcholine transporter unc-17 [Source:UniProtKB/Swiss-Prot;Acc:P34711])

HSP 1 Score: 50.447 bits (119), Expect = 2.750e-6
Identity = 80/368 (21.74%), Postives = 147/368 (39.95%), Query Frame = 1 
Query:  382 FFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHS--IGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATE-IQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            F N   G  +D+V   I +++G         I+AL  S  + +  R L  F S      G ++++  F+  N R     LG  L F+S    + P +G+ +    GK   F +L          +F+                                   + + V ++I+ +     + +D  GEK        +FM       +P+++ C   L + N+S+  L  T+ +WM   +  T     G++W   F  +V GV + V +L+      +   ++   + GI    +P +     L IP+  + F + +I+  L P+  +L D    S YGS+ ++   S +L+   G + +G I   +GF
Sbjct:  115 FVNPFSGYIIDRVGYEIPMILGLCTMFFSTAIFALGKSYGVLLFARSLQGFGSAFADTSGLAMIADRFTEENERSA--ALGIALAFISFGCLVAPPFGSVLYSLAGKPVPFLIL----------SFVCLA--------------------------------DAIAVFMVINPH----RRGTDSHGEKVQGTPMWRLFM-------DPFIACCSGALIMANVSLAFLEPTITTWMSEMMPDTPGWLVGVIWLPPFFPHVLGVYVTVKMLRAFPHHTWAIAMVGLAMEGIACFAIPYTTSVMQLVIPLSFVCFGIALIDTSLLPMLGHLVDTRHVSVYGSVYAIADISYSLAYAFGPIIAGWIVTNWGF 427
[Close]
BLAST of slc18a-1 vs. Ensembl Celegans
Match: cat-1 (pep chromosome:WBcel235:X:5705719:5710625:-1 gene:WBGene00000295.1 transcript:W01C8.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:cat-1)

HSP 1 Score: 49.6766 bits (117), Expect = 4.842e-6
Identity = 46/166 (27.71%), Postives = 82/166 (49.40%), Query Frame = 1 
Query:  982 KIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++ K+PY+      + I NL +  L  +LP WM     A  +++G  +    I Y+ G  +   L   A+++ R+ S  I  +++G  L+ +P +     L IP   + FS+G+I+  +FPL  YL D      YGS+ ++   +   +  +G   SGP+ +  GF
Sbjct:  315 QLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPL---AHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGF 477
[Close]
BLAST of slc18a-1 vs. Ensembl Celegans
Match: cat-1 (pep chromosome:WBcel235:X:5705719:5710585:-1 gene:WBGene00000295.1 transcript:W01C8.6b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:cat-1)

HSP 1 Score: 49.2914 bits (116), Expect = 5.391e-6
Identity = 46/166 (27.71%), Postives = 82/166 (49.40%), Query Frame = 1 
Query:  982 KIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++ K+PY+      + I NL +  L  +LP WM     A  +++G  +    I Y+ G  +   L   A+++ R+ S  I  +++G  L+ +P +     L IP   + FS+G+I+  +FPL  YL D      YGS+ ++   +   +  +G   SGP+ +  GF
Sbjct:  252 QLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPL---AHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGF 414
[Close]
BLAST of slc18a-1 vs. Ensembl Fly
Match: VAChT (gene:FBgn0270928 transcript:FBtr0083671)

HSP 1 Score: 67.0106 bits (162), Expect = 2.101e-11
Identity = 43/183 (23.50%), Postives = 89/183 (48.63%), Query Frame = 1 
Query:  928 KGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            K   K  K+  +  +  ++++ +PY++ C   L + N+++  L  T+  WM   +     + G+VW   F  +V GV + V + +   Q ++        + G    ++P    +++L +PI  + F + +I+  L P   YL D  + S YGS+ ++   S +++  VG + +G + +  GF
Sbjct:  240 KEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGF 422
[Close]
BLAST of slc18a-1 vs. Ensembl Fly
Match: Vmat (gene:FBgn0260964 transcript:FBtr0310062)

HSP 1 Score: 49.6766 bits (117), Expect = 5.554e-6
Identity = 48/183 (26.23%), Postives = 87/183 (47.54%), Query Frame = 1 
Query:  934 EKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            +   QK   E       ++ +PY+      +   N+ +  L  +LP WM   + AT  +QG+ +    I Y+ G  L   L    +++ R+F+  +  II+G  LI +P++     L IP  G+ F++G+++  + P   YL D   ++ YGS+ +L   +  +   VG   SG + +  GF 
Sbjct:  379 QPSIQKAETEP-PSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPL---GHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFE 557
[Close]
BLAST of slc18a-1 vs. Ensembl Fly
Match: Vmat (gene:FBgn0260964 transcript:FBtr0091491)

HSP 1 Score: 49.6766 bits (117), Expect = 5.554e-6
Identity = 48/183 (26.23%), Postives = 87/183 (47.54%), Query Frame = 1 
Query:  934 EKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            +   QK   E       ++ +PY+      +   N+ +  L  +LP WM   + AT  +QG+ +    I Y+ G  L   L    +++ R+F+  +  II+G  LI +P++     L IP  G+ F++G+++  + P   YL D   ++ YGS+ +L   +  +   VG   SG + +  GF 
Sbjct:  379 QPSIQKAETEP-PSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPL---GHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFE 557
[Close]
BLAST of slc18a-1 vs. Ensembl Fly
Match: Vmat (gene:FBgn0260964 transcript:FBtr0091493)

HSP 1 Score: 49.6766 bits (117), Expect = 5.554e-6
Identity = 48/183 (26.23%), Postives = 87/183 (47.54%), Query Frame = 1 
Query:  934 EKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            +   QK   E       ++ +PY+      +   N+ +  L  +LP WM   + AT  +QG+ +    I Y+ G  L   L    +++ R+F+  +  II+G  LI +P++     L IP  G+ F++G+++  + P   YL D   ++ YGS+ +L   +  +   VG   SG + +  GF 
Sbjct:  379 QPSIQKAETEP-PSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPL---GHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFE 557
[Close]
BLAST of slc18a-1 vs. Ensembl Fly
Match: Vmat (gene:FBgn0260964 transcript:FBtr0091492)

HSP 1 Score: 49.6766 bits (117), Expect = 7.305e-6
Identity = 48/183 (26.23%), Postives = 87/183 (47.54%), Query Frame = 1 
Query:  934 EKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            +   QK   E       ++ +PY+      +   N+ +  L  +LP WM   + AT  +QG+ +    I Y+ G  L   L    +++ R+F+  +  II+G  LI +P++     L IP  G+ F++G+++  + P   YL D   ++ YGS+ +L   +  +   VG   SG + +  GF 
Sbjct:  379 QPSIQKAETEP-PSLKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPL---GHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFE 557
[Close]
BLAST of slc18a-1 vs. Ensembl Zebrafish
Match: slc18a3a (solute carrier family 18 member 3a [Source:NCBI gene;Acc:559347])

HSP 1 Score: 71.2478 bits (173), Expect = 1.226e-12
Identity = 47/176 (26.70%), Postives = 87/176 (49.43%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    YK+M +PY++     L   N+ +  L  T+ +WM   + A++ Q G+ W   F  ++ GV L V L      L++F   +  +I+G    ++P   ++  L IP+ G+ F + +++  L P   +L D    S YGS+ ++   S  ++  +G + +G I    GF
Sbjct:  244 RENMPVGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTIANWMEETMNASQWQIGITWLPAFFPHILGVYLTVKLAAKYPHLQWFYGALGMVIIGASSCIVPACKNFEQLIIPLCGVCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYCVAYALGPIVAGKIVHDLGF 419
[Close]
BLAST of slc18a-1 vs. Ensembl Zebrafish
Match: slc18a3b (solute carrier family 18 member 3b [Source:NCBI gene;Acc:394082])

HSP 1 Score: 68.1662 bits (165), Expect = 1.057e-11
Identity = 45/176 (25.57%), Postives = 88/176 (50.00%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    +++M +PY++     L + N+ +  L  T+ +WM   + A++ Q GLVW   F+ +V GV + V L     + ++F   +  +I+G     +P    +  L  P+ G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF
Sbjct:  170 RENMPVGTPIHRLMVDPYIAVVAGALTVCNIPLAFLEPTIANWMESTMDASKWQMGLVWLPAFLPHVLGVYITVRLAARYPERQWFYGALGMVIIGASSCTVPACKTFGELVFPLCGICFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYAMGPVVAGQIVHNLGF 345
[Close]
BLAST of slc18a-1 vs. Ensembl Zebrafish
Match: slc18a2 (solute carrier family 18 member 2 [Source:ZFIN;Acc:ZDB-GENE-080514-1])

HSP 1 Score: 62.003 bits (149), Expect = 1.172e-9
Identity = 70/334 (20.96%), Postives = 141/334 (42.22%), Query Frame = 1 
Query:  478 YALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +A ++S T+  + R L    S    + G  +++ ++++   RG   G+      +   +GP +G+ +   +GK+A F +L  L +                      +  E+++I                                   K +   QK  + I      +MK+PY+      +   N+++  L   LP WM   +C  + Q G+ +    I Y+ G  +  +L   A+++ R+   +I  ++VGI ++ +PL+ D   L +P  G+ F++G+++  + P+  YL D    S YGS+ ++   +  +   +G  + G IA+  GF
Sbjct:  166 FAFSSSYTLLFLARSLQGVGSSCSSVAGMGMLASVYTDDEERGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAVL---------------------DGGERINI--------------------------------CSLKSQDSSQKGTSLI-----TLMKDPYILIAAGSICFANMAIAMLEPALPIWMMETMCPRKWQLGIAFVPASISYLIGTNIFAVL---AHKMGRWLCSLIGMLLVGISILCVPLAKDIYGLIVPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGFALGPSAGGAIARSIGF 438
[Close]
BLAST of slc18a-1 vs. Ensembl Zebrafish
Match: slc18a2 (solute carrier family 18 member 2 [Source:ZFIN;Acc:ZDB-GENE-080514-1])

HSP 1 Score: 61.6178 bits (148), Expect = 1.619e-9
Identity = 70/334 (20.96%), Postives = 140/334 (41.92%), Query Frame = 1 
Query:  478 YALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +A ++S T+  + R L    S    + G  +++ ++++   RG   G+      +   +GP +G+ +   +GK+A F +L  L +   A    + + +                                                    K E + QK  + I      +MK+PY+      +   N+++  L   LP WM   +C  + Q G+ +    I Y+ G  +  +L   A+++ R+   +I  ++VGI ++ +PL+ D   L +P  G+ F++G+++  + P+  YL D    S YGS+ ++   +  +   +G  + G IA+  GF
Sbjct:  224 FAFSSSYTLLFLARSLQGVGSSCSSVAGMGMLASVYTDDEERGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAVLDGALQLFVLQPS----------------------------------------------------KVEPESQKGTSLI-----TLMKDPYILIAAGSICFANMAIAMLEPALPIWMMETMCPRKWQLGIAFVPASISYLIGTNIFAVL---AHKMGRWLCSLIGMLLVGISILCVPLAKDIYGLIVPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGFALGPSAGGAIARSIGF 497
[Close]
BLAST of slc18a-1 vs. Ensembl Zebrafish
Match: SLC18A1 (solute carrier family 18 member A1 [Source:NCBI gene;Acc:571483])

HSP 1 Score: 52.373 bits (124), Expect = 1.010e-6
Identity = 46/168 (27.38%), Postives = 82/168 (48.81%), Query Frame = 1 
Query:  973 KFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
              + ++K+PY+      L   N+ +  L  TLP WM   +CA + Q G+ +    + Y+ G  L  +L       R+   ++   IVGI L+ +P + +   L  P  G+ F+VG+++  +F +  YL D    S YGS+ ++   +L +   VG  + G + +  GF
Sbjct:  281 PLFILLKDPYILISAGSLCFANMGVAVLEPTLPIWMMQTMCAPKWQLGVAFLPASVSYLIGTNLFGILAN--KMGRWLCSMVGMFIVGISLLCVPFAKNLYGLIGPNGGLGFAVGMVDTSMFAIMGYLVDIRHVSVYGSVYAIADVALCVGFAVGPSTGGALVRTIGF 446
[Close]
BLAST of slc18a-1 vs. Ensembl Xenopus
Match: slc18a3 (solute carrier family 18 (vesicular acetylcholine transporter), member 3 [Source:NCBI gene;Acc:780320])

HSP 1 Score: 53.1434 bits (126), Expect = 8.755e-7
Identity = 45/176 (25.57%), Postives = 82/176 (46.59%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            + N  I    +++M +PY++     L   N+ +  L  T+ +WM   + A+E Q GL W   F  +V GV + V L       ++F   I  +I+G     +P   ++  L +P+ G+ F + +++  L P    L D    S YGS+ ++   S  ++  +G + +  I    GF
Sbjct:  254 RANMPIGTPIHRLMIDPYIAVVAGALTTCNIPLAFLEPTIANWMKTTMDASEWQMGLTWLPAFFPHVLGVYITVKLAANYPHYQWFYGAIGMVIIGASSCTVPACKNFWELIVPLCGICFGIALVDTALLPTLALLVDVRHVSVYGSVYAIADISYCVAYALGPVVASQIVHTTGF 429
[Close]
BLAST of slc18a-1 vs. Ensembl Xenopus
Match: gtf2e1.2 (general transcription factor IIE, polypeptide 1, alpha 56kDa, gene 2 [Source:Xenbase;Acc:XB-GENE-6001963])

HSP 1 Score: 53.1434 bits (126), Expect = 9.181e-7
Identity = 43/169 (25.44%), Postives = 88/169 (52.07%), Query Frame = 1 
Query:  973 KFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
             +++++++PY+      L+I N+++  L  TLP WM   +C+ + Q G+ +    + Y+    L  +L   ++++ R+   ++  I+VG  L+ +PL+ +   L  P   +  ++G+++  + P+  YL D    S YG + ++   +L L   VG   +G IA   GF
Sbjct:  243 PYHELLRDPYILVAAACLWIANMAVGMLEPTLPIWMMETMCSPDWQLGIAFLPASVAYLICTNLFGIL---SHKMGRWLCSMLGMIVVGGGLLCVPLARNIYGLIGPNAAIGIALGMVDSSIMPIMGYLVDLRHTSVYGGIYAICDTALCLGFAVGPSLAGVIASNIGF 408
[Close]
BLAST of slc18a-1 vs. Ensembl Xenopus
Match: gtf2e1.2 (general transcription factor IIE, polypeptide 1, alpha 56kDa, gene 2 [Source:Xenbase;Acc:XB-GENE-6001963])

HSP 1 Score: 52.7582 bits (125), Expect = 1.029e-6
Identity = 43/169 (25.44%), Postives = 88/169 (52.07%), Query Frame = 1 
Query:  973 KFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
             +++++++PY+      L+I N+++  L  TLP WM   +C+ + Q G+ +    + Y+    L  +L   ++++ R+   ++  I+VG  L+ +PL+ +   L  P   +  ++G+++  + P+  YL D    S YG + ++   +L L   VG   +G IA   GF
Sbjct:  259 PYHELLRDPYILVAAACLWIANMAVGMLEPTLPIWMMETMCSPDWQLGIAFLPASVAYLICTNLFGIL---SHKMGRWLCSMLGMIVVGGGLLCVPLARNIYGLIGPNAAIGIALGMVDSSIMPIMGYLVDLRHTSVYGGIYAICDTALCLGFAVGPSLAGVIASNIGF 424
[Close]
BLAST of slc18a-1 vs. Ensembl Mouse
Match: Slc18a3 (solute carrier family 18 (vesicular monoamine), member 3 [Source:MGI Symbol;Acc:MGI:1101061])

HSP 1 Score: 65.4698 bits (158), Expect = 1.052e-10
Identity = 79/379 (20.84%), Postives = 152/379 (40.11%), Query Frame = 1 
Query:  349 MIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHS--IGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            ++F SK++ Q   N + G F+D+++  + LLIG G+     +++A           R L    S      G ++++  +     R R   LG  L F+S    + P +G  +    GK   F +L  + +F                                       D    L VA   S+ ++               + N  +    +++M +PY++     L   N+ +  L  T+ +WM   + A+E + G+VW   F+ +V GV L V L      L++    +   ++G+   ++P    +  L + + G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF 
Sbjct:  126 VLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSR--ALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLF---------------------------------------DALLLLAVAKPFSAAAR--------------ARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFE 449
[Close]
BLAST of slc18a-1 vs. Ensembl Mouse
Match: Slc18a1 (solute carrier family 18 (vesicular monoamine), member 1 [Source:MGI Symbol;Acc:MGI:106684])

HSP 1 Score: 56.9954 bits (136), Expect = 3.991e-8
Identity = 46/164 (28.05%), Postives = 82/164 (50.00%), Query Frame = 1 
Query:  985 IMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++K+PY+      + + N+ +  L  TLP WM   +C+ E Q GL +    + Y+ G  L  +L       R+   ++  + VGI L+ +PL+H+   L  P  G+ F++G+++  L P+  YL D    S YGS+ ++   +  +   +G  + G I    GF
Sbjct:  293 LLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLAN--KMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGF 454
[Close]
BLAST of slc18a-1 vs. Ensembl Mouse
Match: Slc18a2 (solute carrier family 18 (vesicular monoamine), member 2 [Source:MGI Symbol;Acc:MGI:106677])

HSP 1 Score: 52.7582 bits (125), Expect = 9.305e-7
Identity = 44/181 (24.31%), Postives = 90/181 (49.72%), Query Frame = 1 
Query:  937 KKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
             + Q E+ +       ++K+PY+      +   N+ +  L   LP WM   +C+ + Q G+ +    I Y+ G  +  +L   A+++ R+   ++  I+VGI ++ +P + +   L  P  G+ F++G+++  + P+  YL D    S YGS+ ++   +  +   +G  + G IA+  GF
Sbjct:  276 SRVQPESQK-GTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGIL---AHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGF 452
[Close]
BLAST of slc18a-1 vs. UniProt/SwissProt
Match: sp|Q08C75|VACHA_DANRE (Probable vesicular acetylcholine transporter-A OS=Danio rerio OX=7955 GN=slc18a3a PE=2 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 9.257e-12
Identity = 47/176 (26.70%), Postives = 87/176 (49.43%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    YK+M +PY++     L   N+ +  L  T+ +WM   + A++ Q G+ W   F  ++ GV L V L      L++F   +  +I+G    ++P   ++  L IP+ G+ F + +++  L P   +L D    S YGS+ ++   S  ++  +G + +G I    GF
Sbjct:  244 RENMPVGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTIANWMEETMNASQWQIGITWLPAFFPHILGVYLTVKLAAKYPHLQWFYGALGMVIIGASSCIVPACKNFEQLIIPLCGVCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYCVAYALGPIVAGKIVHDLGF 419
[Close]
BLAST of slc18a-1 vs. UniProt/SwissProt
Match: sp|P59845|VACHB_DANRE (Probable vesicular acetylcholine transporter-B OS=Danio rerio OX=7955 GN=slc18a3b PE=2 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 9.709e-11
Identity = 45/176 (25.57%), Postives = 88/176 (50.00%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    +++M +PY++     L + N+ +  L  T+ +WM   + A++ Q GLVW   F+ +V GV + V L     + ++F   +  +I+G     +P    +  L  P+ G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF
Sbjct:  232 RENMPVGTPIHRLMVDPYIAVVAGALTVCNIPLAFLEPTIANWMESTMDASKWQMGLVWLPAFLPHVLGVYITVRLAARYPERQWFYGALGMVIIGASSCTVPACKTFGELVFPLCGICFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYAMGPVVAGQIVHNLGF 407
[Close]
BLAST of slc18a-1 vs. UniProt/SwissProt
Match: sp|P81721|VACHT_TETCF (Vesicular acetylcholine transporter OS=Tetronarce californica OX=7787 PE=2 SV=2)

HSP 1 Score: 67.0106 bits (162), Expect = 1.880e-10
Identity = 45/176 (25.57%), Postives = 85/176 (48.30%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN       YK+M +PY++     L   N+ +  L  T+ +WM   + A+E Q G+ W   F  ++ GV + V L       ++F   +  +I+G     +P   ++  L IP+  + F + +++  L P   +L D  + S YGS+ ++   S +++  +G + +G I    GF
Sbjct:  258 RENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGF 433
[Close]
BLAST of slc18a-1 vs. UniProt/SwissProt
Match: sp|O17444|VACHT_DROME (Vesicular acetylcholine transporter OS=Drosophila melanogaster OX=7227 GN=VAChT PE=2 SV=2)

HSP 1 Score: 67.0106 bits (162), Expect = 2.106e-10
Identity = 43/183 (23.50%), Postives = 89/183 (48.63%), Query Frame = 1 
Query:  928 KGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            K   K  K+  +  +  ++++ +PY++ C   L + N+++  L  T+  WM   +     + G+VW   F  +V GV + V + +   Q ++        + G    ++P    +++L +PI  + F + +I+  L P   YL D  + S YGS+ ++   S +++  VG + +G + +  GF
Sbjct:  240 KEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGF 422
[Close]
BLAST of slc18a-1 vs. UniProt/SwissProt
Match: sp|O35304|VACHT_MOUSE (Vesicular acetylcholine transporter OS=Mus musculus OX=10090 GN=Slc18a3 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 3.046e-10
Identity = 79/379 (20.84%), Postives = 153/379 (40.37%), Query Frame = 1 
Query:  349 MIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHS--IGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            ++F SK++ Q   N + G F+D+++  + LLIG G+     +++A       +   R L    S      G ++++  +     R R   LG  L F+S    + P +G  +    GK   F +L  + +F                                       D    L VA   S+ ++               + N  +    +++M +PY++     L   N+ +  L  T+ +WM   + A+E + G+VW   F+ +V GV L V L      L++    +   ++G+   ++P    +  L + + G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF 
Sbjct:  126 VLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATFFAARSLQGLGSAFADTSGIAMIADKYPEEPERSR--ALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLF---------------------------------------DALLLLAVAKPFSAAAR--------------ARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFE 449
[Close]
BLAST of slc18a-1 vs. TrEMBL
Match: A0A0H3YJ27 (Slc18a-1 OS=Schmidtea mediterranea OX=79327 GN=slc18a-1 PE=2 SV=1)

HSP 1 Score: 851.662 bits (2199), Expect = 0.000e+0
Identity = 474/474 (100.00%), Postives = 474/474 (100.00%), Query Frame = 1 
Query:  136 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRXXXXXXXXXXXXXXXXXXPHQKLVQS 1557
            MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFIILLIGQGLGIIIALIYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPIIAQIIVGILLILLPLSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRSLCICLGILNLLFCLLSLPHQKLVQS
Sbjct:    1 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFIILLIGQGLGIIIALIYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPIIAQIIVGILLILLPLSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRSLCICLGILNLLFCLLSLPHQKLVQS 474
[Close]
BLAST of slc18a-1 vs. TrEMBL
Match: A0A0H3YK88 (Slc18a-8 OS=Schmidtea mediterranea OX=79327 GN=slc18a-8 PE=2 SV=1)

HSP 1 Score: 335.109 bits (858), Expect = 1.053e-105
Identity = 199/450 (44.22%), Postives = 292/450 (64.89%), Query Frame = 1 
Query:  136 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQ-CHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDD-HNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            M FK D+ LA +V+ LNF+++ +QE+SLY ILPKY  ++   +  NET   N+  T+ Q C  QKPPY +VS IFLSK++A  F N  IG  + K+N +IIL++   +GI ++ IYA  +++ +YI+GR+LD+F++C + IG + ++SKLF  +  R R++ L N +YF+SHSIGP YGAEVD R GKS VF +L+PLWI  +  T  LY R   R  +S+     KL           LD+  NE  V I+    +KM       +  +K  K  N I    YK +++P+V  CL QLF+VNLSM++LP TLPSWM    C++EI+QG+VW FGF+GY+ GV  ++++ K AY+ R++ P++  +++GIL+I+LP S DW+++F+PI+GMY  VG ++Q++ PLT  LA     S+   ++SLTSQSLT+S V+ TL  G I   FGF 
Sbjct:    1 MFFKFDNLLAGVVVSLNFFLMVLQENSLYAILPKYFSNQTSISARNETVLINS--TVPQNCSFQKPPYVVVSQIFLSKNVAMIFLNIFIGIIIYKLNIYIILILSHFVGIGVSFIYAYTDTLLLYIIGRVLDSFITCGILIGIYFLISKLFIVIEVRDRYYALVNIIYFISHSIGPFYGAEVDERFGKSTVFLILVPLWIVCLLLTVFLYWRNRNRSKRSE----IKLEGQRQKPNLESLDECINEANVQIL--DKAKMD---IFVQNSRKKTKTLNII----YKFIRDPFVMLCLGQLFVVNLSMYSLPPTLPSWMASEFCSSEIEQGIVWTFGFLGYIVGVVTVIIVDKHAYRFRYYVPVVGHLMIGILMIILPFSRDWKMVFLPIVGMYVGVGFVDQIVIPLTINLAIFRHKSNTNIVSSLTSQSLTISSVISTLLCGHIVMLFGFH 435
[Close]
BLAST of slc18a-1 vs. TrEMBL
Match: A0A267GQ21 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025894g2 PE=4 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 6.542e-19
Identity = 98/398 (24.62%), Postives = 169/398 (42.46%), Query Frame = 1 
Query:  364 KSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSK-NNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMK------FYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVW--------------------AFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            K L Q   N +IG  +D +    ILL+G        L+Y L +S  ++++ R ++   S ++   G + V+  F+++  R R  G+ N + F ++++GP YG  +  R G+  VF   +P++  T      L R+   R    +        S    P    +     +   A+ +SS +  P               + E+  K       ++++ +P++++C   L + NLS   L ATL  WM  R  AT+ Q+GLVW                    A  + G+V+  GL++  L CA  L  F P                   W  L  PI  ++ S+ V++  L PL ++L D      YGS++ +   S +++   G  ++GPI    GF
Sbjct:   81 KGLVQIAMNPLIGKLIDLLFPAAILLVGIAADCTSILLYGLGDSYWVFLLARAVNGAGSAAIGTSGLAQVATCFTSLRMRNRAIGIANFVLFSANALGPAYGGFIYERTGRGVVFLAYLPMFAATACLLVPLLRQGLVRQRGGRPEGPAAPQSPQHPPPSQQQQPQQQDAGDAVAVSSPTSSPAAIDADHLVVPDNDNDEEVAAKRPKPTPLWRLLTDPHIAACAGGLIVANLSHNCLAATLGIWMHHRYEATDTQKGLVWLPTLPFHFAATVASVWLCNRAPAWRGWVAAGGLVLGGLACA--LLPFMP----------------GKAWCTL--PIGLVFASIAVLDVTLLPLLSHLVDRRHTPVYGSVSCIAHASFSIATAFGAFAAGPIFLHLGF 458
[Close]
BLAST of slc18a-1 vs. TrEMBL
Match: A0A267HB05 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025894g1 PE=4 SV=1)

HSP 1 Score: 97.0561 bits (240), Expect = 2.016e-17
Identity = 96/383 (25.07%), Postives = 172/383 (44.91%), Query Frame = 1 
Query:  364 KSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRR--TEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMK------FYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVW----AFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            K L Q   N +IG  +D +    ILL+G     I  L+Y L +S  ++++ R ++   S ++   G + V+  F+++  R R  G+ N + F ++++GP YG  +  R G+  VF   +P++  T      L R+    +R  + +     + S    P    +     +   A+ +SS +  P               + E+  K       ++++ +P++++C   L + NLS   L ATL  WM  R  AT+ Q+GLVW     F F   V+ V L       A++    +  +A   +   L+       W  L  PI  ++ S+ V++  L PL ++L D      YGS++ +   S +++   G  ++GPI    GF
Sbjct:  120 KGLVQIAMNPLIGKLIDLLFPAAILLVGIAADCISILLYGLGDSYWVFLLARAVNGAGSAAIGTSGLAQVATCFTSLRMRNRAIGIANFVLFSANALGPAYGGFIYERTGRGVVFLAYLPMFAATACLLVPLLRQGLVRQRGGRPEGPAAPQ-SPQHRPPSQQQQPQQQDAGDAVAVSSPTSSPAAIDADHLVVPDSGNDEEVAAKRPKPTPLWRLLTDPHIAACAGGLIVANLSHNCLAATLGIWMHHRYEATDTQKGLVWLPTLPFHFAATVASVWLCNR--APAWRGWVAAGGLALGGLACALLPFMPGKAWCTL--PIGLVFASIAVLDVTLLPLLSHLVDRRHTPVYGSVSCIAHASFSIATAFGAFAAGPIFLHLGF 497
[Close]
BLAST of slc18a-1 vs. TrEMBL
Match: A0A0H3YFB7 (Slc18a-2 OS=Schmidtea mediterranea OX=79327 GN=slc18a-2 PE=2 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 4.067e-16
Identity = 108/467 (23.13%), Postives = 198/467 (42.40%), Query Frame = 1 
Query:  217 LYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGA---EVDVRLGKSAV----FFLLIPLWIFTMAAT---------------FILYRRTEKRCNKSKNNFNE---KLSIGVTPDETNELDDHNELKVA-IIISSNSKMPEKYSDFKG-----------------EKKFQKENNEIFMK----FYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            + T+ P Y        ++ +T   N S     C    P    VS++  SK   +     I+G   D+ +   IL  G  +     ++Y ++++    I+ R++DA     +   G +I+  ++ N  +R +     + L +++ S  P+      E   ++ K +     F  L PL+I    A                  + ++    C K +N  NE     S+ V  ++ N ++   +   +  I SS SK  +++ D K                  +    K  N + MK      K++K+P+V   L  L   +L   +L  TLP +M  + C+ + QQG VW FGF   + G  L  +L      + +  P++  +I G + I +  S  W ++ + +  M+F   + E +L P+   + D  ++  YGS + LT  + T+SG++GT   GP+ + FGF
Sbjct:   30 ITTVFPAY--------SSVKTEIENVSIASTNCSNDNPSNVYVSILIGSKYGTELIMFPIVGWITDRSHPPQILFTGALIEAFACVVYCISDNFYSSILARIIDAIGYSIVSTSGLTIIYTIYVNERSRNKVITFDSILVYIAGSTSPIIAGAIFESASKINKDSARIFTFVWLCPLFIILAVAISPFAFRNSYMSRYFGISVVKKKSVECKKFQNGKNELDINNSLLVKENDGNNINSTLQQDCSESIPSSGSKNADQFIDHKMVPNKMSSSLSLPDVDVIDISQTKSKNHLEMKKQLSAAKLLKDPHVMVVLTVLMFNSLIGNSLETTLPIFMIKKFCSDQTQQGAVWLFGFFSLI-GFFLSSMLFHLKTSVCWILPMVGIVINGAICICIFFSKPWWVIGVCLGFMFFFSSMTECILIPVVPKIIDIKYSKSYGSASGLTLLTFTISGLIGTFPIGPLVEYFGF 487
[Close]
BLAST of slc18a-1 vs. Ensembl Cavefish
Match: slc18a3b (solute carrier family 18 member 3b [Source:NCBI gene;Acc:394082])

HSP 1 Score: 69.707 bits (169), Expect = 3.137e-12
Identity = 44/176 (25.00%), Postives = 90/176 (51.14%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++N    +  ++++ +PY++     L + N+ +  L  T+  WM   + AT+ Q GL W   F  +V GV L V L +    +++F   +  +I+G    ++P    +  L +P+ G+ F + +++  L P   +L D  + S YGS+ ++   S +++  +G +++G I    GF
Sbjct:  216 RQNQPAGVPLHRLIMDPYIAVVAGALTVCNIPLAFLEPTIAGWMENTMHATKWQIGLAWLPSFFPHVLGVYLTVKLAERYPSMQWFYGAVGMLIIGASSCVVPACKSFSQLMLPLCGICFGIALVDTALLPTMAFLVDVRYASVYGSVYAIADISYSVAYALGPVAAGHIVHTMGF 391
[Close]
BLAST of slc18a-1 vs. Ensembl Cavefish
Match: slc18a3a (solute carrier family 18 member A3 [Source:NCBI gene;Acc:103044616])

HSP 1 Score: 69.707 bits (169), Expect = 3.152e-12
Identity = 47/176 (26.70%), Postives = 86/176 (48.86%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    YK+M +PY++     L   N+ +  L  T+ +WM   + +++ Q GL W   F  +V GV + V L      L++F   +  +I+G     +P   ++  L IP+ G+ F + +++  L P   +L D    S YGS+ ++   S  ++  +G + +G I    GF
Sbjct:  250 RENMPVGPPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTIANWMEETMDSSQWQIGLTWLPAFFPHVLGVYITVKLAAQYPHLQWFYGALGMVIIGASSCTVPACKNFEQLIIPLCGICFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYCVAYAMGPIVAGKIVHDLGF 425
[Close]
BLAST of slc18a-1 vs. Ensembl Cavefish
Match: slc18a2 (synaptic vesicular amine transporter [Source:NCBI gene;Acc:103032219])

HSP 1 Score: 56.9954 bits (136), Expect = 3.466e-8
Identity = 66/333 (19.82%), Postives = 134/333 (40.24%), Query Frame = 1 
Query:  478 YALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +A ++S T+  + R +    S    + G  +++ ++++   RG   G+      +   +GP +G+ +   +GK+A F +L  L +   A    + + +                                                    K E + QK  +        +MK+PY+      +   N+++  L   LP WM   +CA + Q G+ +    + Y+ G  +  +L       R+   +I  ++VGI ++ +P + D   L +P  G+ F++G+++  + P+  YL D    S YGS+ ++   +  +    G  + G IA+  GF
Sbjct:  174 FAFSSSYTLLFLARSMQGVGSSCSSVAGMGMLASVYTDDEERGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAVLDGALQLFVLQPS----------------------------------------------------KVEPESQKGTS-----LMTLMKDPYILIAAGSICFANMAIAMLEPALPIWMMETMCARKWQLGVAFLPASVSYLIGTNIFAVLAN--KMGRWLCALIGMLLVGISILCVPFAKDIYGLILPNFGVGFAIGMVDSSMMPIMGYLVDLRHISVYGSVYAIADVAFCMGFAFGPSAGGAIARSIGF 447
[Close]
BLAST of slc18a-1 vs. Ensembl Cavefish
Match: SLC18A1 (solute carrier family 18 member A1 [Source:NCBI gene;Acc:103028146])

HSP 1 Score: 49.6766 bits (117), Expect = 6.918e-6
Identity = 47/164 (28.66%), Postives = 82/164 (50.00%), Query Frame = 1 
Query:  985 IMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++K+PY+      L   N+ +  L  TLP WM   +C+ + Q G+ +    + Y+ G  L  LL       R+   +I   IVGI LI +PL+ +   L  P  G+ F++G+++  +  +  YL D   +S YGS+ ++   +L +   +G  + G I +  GF
Sbjct:  284 LLKDPYILISAGSLCFANMGVAILEPTLPIWMMQTMCSQKWQLGVAFLPASVSYLIGTNLFGLLAN--KMGRWLCSMIGMFIVGISLICVPLASNIYGLIGPNGGLGFAIGMVDSSMMAIMGYLVDIRHSSVYGSVYAIADVALCMGFAIGPSTGGAIVRVIGF 445
[Close]
BLAST of slc18a-1 vs. Ensembl Cavefish
Match: SLC18A1 (solute carrier family 18 member A1 [Source:NCBI gene;Acc:103028146])

HSP 1 Score: 49.6766 bits (117), Expect = 7.287e-6
Identity = 47/164 (28.66%), Postives = 82/164 (50.00%), Query Frame = 1 
Query:  985 IMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++K+PY+      L   N+ +  L  TLP WM   +C+ + Q G+ +    + Y+ G  L  LL       R+   +I   IVGI LI +PL+ +   L  P  G+ F++G+++  +  +  YL D   +S YGS+ ++   +L +   +G  + G I +  GF
Sbjct:  292 LLKDPYILISAGSLCFANMGVAILEPTLPIWMMQTMCSQKWQLGVAFLPASVSYLIGTNLFGLLAN--KMGRWLCSMIGMFIVGISLICVPLASNIYGLIGPNGGLGFAIGMVDSSMMAIMGYLVDIRHSSVYGSVYAIADVALCMGFAIGPSTGGAIVRVIGF 453
[Close]
BLAST of slc18a-1 vs. Ensembl Sea Lamprey
Match: slc18a3a (solute carrier family 18 member 3a [Source:NCBI gene;Acc:559347])

HSP 1 Score: 78.1814 bits (191), Expect = 1.478e-15
Identity = 89/378 (23.54%), Postives = 151/378 (39.95%), Query Frame = 1 
Query:  349 MIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHS--IGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++F SK++ Q   N + G F+D+V   + LLIG  +  +   ++A   S       R L    S        ++++  F+    R R   LG  L F+S    + P +G  +   +GK       +P  +    + F                                 D    + VA   SS S+                EN       Y++M +PY+      L + N+ +  L  T+ SWM   + A E Q+G+ W   F  +V GV + V L     QL++F   +  +I+G    L+P    +  L  P+ G+ F + +++  L PL  +L D    S YGS+ ++   S +L+  +G + +G I    GF
Sbjct:  119 ILFASKAIVQLLVNPLTGTFIDRVGYDLPLLIGLSIIFLSTAVFAFGESYATLFAARSLQGLGSAFADTAAIAMIADRFTEEAERSR--ALGIALAFISFGSLVAPPFGGTLYEFVGKR------VPFLVLACVSLF---------------------------------DGLLLMVVAKPFSSRSR----------------ENMPQGTPIYRLMMDPYIVVVAGALTMANIPLAFLEPTIASWMKKTMGANEWQRGMTWLPAFFPHVLGVYITVKLAAKYPQLQWFYGGLGLVIIGSSSCLVPACRTFEELIAPLCGICFGIALVDTALLPLLAFLVDVRHASVYGSVYAIADISYSLAYAMGPIVAGQIVHTMGF 439
[Close]
BLAST of slc18a-1 vs. Ensembl Sea Lamprey
Match: slc18a2 (solute carrier family 18 member 2 [Source:ZFIN;Acc:ZDB-GENE-080514-1])

HSP 1 Score: 51.2174 bits (121), Expect = 4.431e-7
Identity = 76/364 (20.88%), Postives = 148/364 (40.66%), Query Frame = 1 
Query:  388 NSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQL-RFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            N  IG   ++V     +  G  +  +  +++A   S  +  + R L    S    + G  +++ L+ +   RG   G+      +   +GP +G+ +   +GK A F +L  L +F  A                                         L++ ++  S S+ PE               ++       ++++PY+      + I N+ +  L   LP WM   +C+ + Q G+ +    I Y  G  +   L   A+++ R+   +I  ++VGI +I +PL+     L +P  G+ F++G+++  + PL  YL D    S YGS+ ++   +  +   +G  + G IA+  GF
Sbjct:  166 NPFIGPLTNRVGYHSPMFAGFIIMFLSTIMFAFAQSYPLLFLARALQGIGSSCSSVAGMGMLASLYPDDEERGNAMGVALGGLAMGVLVGPPFGSIMYDFVGKPAPFLVLAGLALFDGA-----------------------------------------LQMLVLQPSKSE-PE---------------SQTGTPLLTLLRDPYILITAGSICIANMGIAMLEPALPIWMMETMCSPKWQLGVAFIPASISYWIGTNIFGPL---AHKMGRWLCALIGMVVVGISIICVPLAKTIYGLIVPNFGVGFAIGMVDSSMMPLMGYLVDLRHVSVYGSVYAIADVAFCMGFALGPSAGGAIARTIGF 469
[Close]
BLAST of slc18a-1 vs. Ensembl Medaka
Match: slc18a3a (solute carrier family 18 member 3a [Source:NCBI gene;Acc:559347])

HSP 1 Score: 72.0182 bits (175), Expect = 5.866e-13
Identity = 48/177 (27.12%), Postives = 86/177 (48.59%), Query Frame = 1 
Query:  946 QKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            ++ N  +    YK+M +PY++     L I N+ +  L  T+ +WM   + ATE + G+ W   F  +V GV L V L      L++F   +  + +G     +P   ++  L IP+ G+ F + +++  L P   +L D    S YGS+ ++   S  ++  +G + +G I    GF
Sbjct:  254 ERGNMPVGTPIYKLMIDPYIAVVAGALIICNIPLAFLEPTIANWMEDTMQATEWEIGMTWFPAFFPHVLGVYLTVKLAAKHPHLQWFYGAMGMVFIGASSCTVPACKNFGQLMIPLCGVCFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYCVAYALGPVVAGQIVHNLGF 430
[Close]
BLAST of slc18a-1 vs. Ensembl Medaka
Match: slc18a3b (probable vesicular acetylcholine transporter-B [Source:NCBI gene;Acc:101163117])

HSP 1 Score: 70.8626 bits (172), Expect = 1.445e-12
Identity = 46/176 (26.14%), Postives = 86/176 (48.86%), Query Frame = 1 
Query:  949 KENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
            +EN  +    YK+M +PY++     L + N+ +  L  T+ +WM   + +T+ + GL W   F  +V GV + V L      L++F   +  +I+G     +P    +  L  P+ G+ F + +++  L P   +L D    S YGS+ ++   S +++  +G + +G I    GF
Sbjct:  253 RENMPVGTPIYKLMVDPYIAVVAGALTVANIPLAFLEPTIANWMETTMHSTQWEMGLTWLPAFFPHVLGVYITVKLAAKNPHLQWFYGALGMVIIGASSCTVPACKTFGQLIAPLCGICFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYAMGPIVAGQIVHTLGF 428
[Close]
BLAST of slc18a-1 vs. Planmine SMEST
Match: SMESG000041557.1 (SMESG000041557.1)

HSP 1 Score: 840.877 bits (2171), Expect = 0.000e+0
Identity = 470/474 (99.16%), Postives = 470/474 (99.16%), Query Frame = 1 
Query:  136 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRXXXXXXXXXXXXXXXXXXPHQKLVQS 1557
            MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFIILLIGQGLGIIIALIYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNN NEKLSIGVTPDETNELDDHNELKVAIIISS SK PEKYSDFKGEKKFQKEN EIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPIIAQIIVGILLILLPLSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRSLCICLGILNLLFCLLSLPHQKLVQS
Sbjct:    1 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFIILLIGQGLGIIIALIYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNCNEKLSIGVTPDETNELDDHNELKVAIIISSISKTPEKYSDFKGEKKFQKENKEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPIIAQIIVGILLILLPLSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRSLCICLGILNLLFCLLSLPHQKLVQS 474
[Close]
BLAST of slc18a-1 vs. Planmine SMEST
Match: SMESG000041535.1 (SMESG000041535.1)

HSP 1 Score: 437.573 bits (1124), Expect = 3.381e-149
Identity = 258/453 (56.95%), Postives = 321/453 (70.86%), Query Frame = 1 
Query:  193 MLGIQESSLYTILPKYLVDE--------------------PFNATNNE--TFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKN--NFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            M+ I ESSLYTILPKYLVD+                     FN T N+    + N S+    CH+QKPPYFIVSM+FLSK+LAQ   N IIGC ++K+N++ IL+  Q  GI++ALIYA  NS+  Y+ GR+LDAFV+ + +I   +I+S LFS++NTRGR+ GLGNTLYF SHSIG VYGAE+D RLGKS VFFLLIPLWI T++ T  +Y R + +          ++K +I     E   L++ N  +    + ++ + P+K SDF   K   K N    +    ++K P V  CL QLFIVN SMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGL+ L  K A +  F++PIIAQ+I+GILLILLP SHDWRL+FIPIIGMYF VG++EQV+FPLTT+LAD  FNSDYG+M+SLTSQSLT+ GV+GTLSSGPIA+RFGF 
Sbjct:    1 MMSIPESSLYTILPKYLVDQLNNVTANTTANTTVNATINITFNVTLNDRINLRINISKL---CHIQKPPYFIVSMVFLSKNLAQVVSNLIIGCIIEKINHYFILIAAQCFGIVVALIYAFGNSVVAYMCGRVLDAFVNAASYISILAIISSLFSDINTRGRYIGLGNTLYFFSHSIGAVYGAEIDTRLGKSPVFFLLIPLWIVTISITISIYSRVQDKVKYGHEIKKCDDKETI-----EIENLNNENTSEYPAEVINSVQNPDKDSDFSPMKA--KPNKSPLISIMWMLKTPSVLICLIQLFIVNFSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLVTLTFKYAPKFIFYNPIIAQMIIGILLILLPFSHDWRLVFIPIIGMYFCVGIVEQVIFPLTTHLADRDFNSDYGTMSSLTSQSLTICGVMGTLSSGPIAERFGFH 443
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BLAST of slc18a-1 vs. Planmine SMEST
Match: SMESG000069017.1 (SMESG000069017.1)

HSP 1 Score: 398.667 bits (1023), Expect = 8.687e-133
Identity = 219/446 (49.10%), Postives = 311/446 (69.73%), Query Frame = 1 
Query:  142 FKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETN-ELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGF 1476
             + D  L  IV+ LNF+M+ I+ESSLYTILPKYL +  F   NN + +   S    +C  + PPY I+SMIFLSK+LA  F N IIG  +D++NNFIIL+  Q LG+ + L+YA +NSI MYI+GR++DAFV+  +F+  +SI+S++F     R +++G  NTL+FVSHS+GPVYGA VD + GKSAVF LLIP+W  ++  T++L+RR  K  NK+K      L I    +  +  +D  N     +I+S +S+  E     K E K Q  N+      +K++K+P V +CL Q+F+VNL MF+LP TLPSWM F+LC++E+QQG+VW+FGF+GY+ GV L++++   A + R  +P+  QII+GI LI++P + DWR LF+PIIGMY SVGV+EQ++ PLTTYL+D  +NS+YG+M+SLTSQSL L  V+ +L SGPIA+++GF
Sbjct:   96 LRSDYLLVIIVVGLNFFMMVIEESSLYTILPKYLSNRTFGEINNYS-RIYASNLSMKCVSKDPPYVIISMIFLSKNLATIFINPIIGMILDRMNNFIILIFAQILGVSVLLVYAFSNSILMYIIGRIIDAFVTSVIFLAVYSIISQMFLETRIRSKYYGFVNTLFFVSHSLGPVYGASVDEKFGKSAVFLLLIPIWSISLLFTYLLHRRI-KTINKNKKGVPRFLEIMENHNWNDTRVDSPNNESKNLILSESSEKNETI-KVKIENK-QSGNHRTLFTIFKMLKDPKVLACLVQIFVVNLCMFSLPPTLPSWMAFKLCSSELQQGIVWSFGFLGYILGVSLVIIIDAYAPRFRNLAPVAGQIIIGIQLIMIPFTRDWRFLFLPIIGMYISVGVVEQIILPLTTYLSDSLYNSNYGTMSSLTSQSLNLCSVISSLCSGPIAEKYGF 537
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BLAST of slc18a-1 vs. Planmine SMEST
Match: SMESG000064367.1 (SMESG000064367.1)

HSP 1 Score: 313.538 bits (802), Expect = 3.180e-101
Identity = 186/427 (43.56%), Postives = 276/427 (64.64%), Query Frame = 1 
Query:  202 IQESSLYTILPKYLVDEPFNATNNETFKPNTSRTIFQ-CHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFXXXXXXXXXXXXXXXXYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLFSNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            +QE+SLY ILPKY  ++   +  NET   N+  T+ Q C  QKPPY +VS IFLSK++A  F N  IG  + K+N +IIL++   +GI ++ IYA  +++ +YI+GR+LD+F++C + IG + ++SKLF  +  R R++ L N +YF+SHSIGP YGAEVD R GKS VF +L+PLWI  +  T  LY R   R  +S+     +      P+  +  +  NE  V I+    +KM       +  +K  K  N I    YK +++P+V  CL QLF+VNLSM++LP TLPSWM    C++EI+QG+VW FGF+GY+ GV  ++++ K AY+ R++ P++  +++GIL+I+LP S DW+++F+PI+GMY  VG ++Q++ PLT  LA     S+   ++SLTSQSLT+S V+ TL  G I   FGF 
Sbjct:    3 LQENSLYAILPKYFSNQTSISARNETVLINS--TVPQNCSFQKPPYVVVSQIFLSKNVAMIFLNIFIGIIIYKLNIYIILILSHFVGIGVSFIYAYTDTLLLYIIGRVLDSFITCGILIGIYFLISKLFIVIEVRDRYYALVNIIYFISHSIGPFYGAEVDERYGKSTVFLILVPLWIVCLLLTVFLYWRNRNRSKRSEIKLEGQRQ---KPNLESLDECINEANVQIL--DKAKMD---IFVQNSRKKTKTLNII----YKFIRDPFVMLCLGQLFVVNLSMYSLPPTLPSWMASEFCSSEIEQGIVWTFGFLGYIVGVVTVIIVDKHAYRFRYYVPVVGHLMIGILMIILPFSRDWKMVFLPIVGMYVGVGFVDQIVIPLTINLAIFRHKSNTNIVSSLTSQSLTISSVISTLLCGHIVMLFGFH 415
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BLAST of slc18a-1 vs. Planmine SMEST
Match: SMESG000041534.1 (SMESG000041534.1)

HSP 1 Score: 301.982 bits (772), Expect = 4.708e-97
Identity = 168/280 (60.00%), Postives = 202/280 (72.14%), Query Frame = 1 
Query:  643 SHSIGPVYGAEVDVRLGKSAVFFLLIPLWIFTMAATFILYRRTEKR-CNKSKNNFNEKLSIGVTPDETNELDDHNELKVAIIISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIVNLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKCAYQLRFFSPXXXXXXXXXXXXXXXXSHDWRLLFIPIIGMYFSVGVIEQVLFPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFR 1479
            SHSIG VYGAE+D RLGKS VFF LIPLWI T+  T +L +       N  KN    K        ETN   + N+ ++   + ++ + P+K SDF   K   K N    +   +++K P+V  CL QLFI N SMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGL+ L  K A +  F++PII+Q+I GILLILLP SHDWRL+FIPIIGMYF VG++EQV+FPLTT+LAD  FNSDYG+M+SLTSQS+T+  V GTLSSGPIA+RFGF 
Sbjct:  117 SHSIGAVYGAEIDSRLGKSPVFFFLIPLWIVTILVTILLCKNVSNGFQNDDKNEAGIKTIYNKDIIETNNESEGNKKEIQKQVINSDQSPDKDSDFCPMK--VKPNKSPLISIMRMLKTPFVLICLIQLFIANFSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLVTLTFKYAPKFIFYTPIISQMISGILLILLPFSHDWRLVFIPIIGMYFCVGIVEQVIFPLTTHLADRDFNSDYGTMSSLTSQSMTICRVFGTLSSGPIAERFGFH 394

HSP 2 Score: 78.1814 bits (191), Expect = 3.827e-15
Identity = 46/110 (41.82%), Postives = 62/110 (56.36%), Query Frame = 1 
Query:  136 MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNE------------TFKPNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNF 429
            M F C   L  +++ LN +M+ I ES+LYTILPKY VD+  ++T N               + N S+    C L+KPPYF+VSM+FL+K+LAQ   NSI    V   NN 
Sbjct:    1 MQFNCGSVLVILMVSLNSFMITIPESTLYTILPKYFVDKHRSSTTNNNTIVDVTVNDTTNLRINISKL---CPLKKPPYFMVSMVFLAKNLAQVISNSIRNVLVFHGNNL 107
The following BLAST results are available for this feature:
BLAST of slc18a-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
SLC18A35.219e-1020.58solute carrier family 18 member A3 [Source:HGNC Sy... [more]
SLC18A21.316e-625.45solute carrier family 18 member A2 [Source:HGNC Sy... [more]
SLC18A11.392e-625.00solute carrier family 18 member A1 [Source:HGNC Sy... [more]
SLC18A11.392e-625.00solute carrier family 18 member A1 [Source:HGNC Sy... [more]
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BLAST of slc18a-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
unc-172.750e-621.74Vesicular acetylcholine transporter unc-17 [Sourc... [more]
cat-14.842e-627.71pep chromosome:WBcel235:X:5705719:5710625:-1 gene:... [more]
cat-15.391e-627.71pep chromosome:WBcel235:X:5705719:5710585:-1 gene:... [more]
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BLAST of slc18a-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
VAChT2.101e-1123.50gene:FBgn0270928 transcript:FBtr0083671[more]
Vmat5.554e-626.23gene:FBgn0260964 transcript:FBtr0310062[more]
Vmat5.554e-626.23gene:FBgn0260964 transcript:FBtr0091491[more]
Vmat5.554e-626.23gene:FBgn0260964 transcript:FBtr0091493[more]
Vmat7.305e-626.23gene:FBgn0260964 transcript:FBtr0091492[more]
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BLAST of slc18a-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
slc18a3a1.226e-1226.70solute carrier family 18 member 3a [Source:NCBI ge... [more]
slc18a3b1.057e-1125.57solute carrier family 18 member 3b [Source:NCBI ge... [more]
slc18a21.172e-920.96solute carrier family 18 member 2 [Source:ZFIN;Acc... [more]
slc18a21.619e-920.96solute carrier family 18 member 2 [Source:ZFIN;Acc... [more]
SLC18A11.010e-627.38solute carrier family 18 member A1 [Source:NCBI ge... [more]
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BLAST of slc18a-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
slc18a38.755e-725.57solute carrier family 18 (vesicular acetylcholine ... [more]
gtf2e1.29.181e-725.44general transcription factor IIE, polypeptide 1, a... [more]
gtf2e1.21.029e-625.44general transcription factor IIE, polypeptide 1, a... [more]
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BLAST of slc18a-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Slc18a31.052e-1020.84solute carrier family 18 (vesicular monoamine), me... [more]
Slc18a13.991e-828.05solute carrier family 18 (vesicular monoamine), me... [more]
Slc18a29.305e-724.31solute carrier family 18 (vesicular monoamine), me... [more]
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BLAST of slc18a-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q08C75|VACHA_DANRE9.257e-1226.70Probable vesicular acetylcholine transporter-A OS=... [more]
sp|P59845|VACHB_DANRE9.709e-1125.57Probable vesicular acetylcholine transporter-B OS=... [more]
sp|P81721|VACHT_TETCF1.880e-1025.57Vesicular acetylcholine transporter OS=Tetronarce ... [more]
sp|O17444|VACHT_DROME2.106e-1023.50Vesicular acetylcholine transporter OS=Drosophila ... [more]
sp|O35304|VACHT_MOUSE3.046e-1020.84Vesicular acetylcholine transporter OS=Mus musculu... [more]
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BLAST of slc18a-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0H3YJ270.000e+0100.00Slc18a-1 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
A0A0H3YK881.053e-10544.22Slc18a-8 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
A0A267GQ216.542e-1924.62Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267HB052.016e-1725.07Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A0H3YFB74.067e-1623.13Slc18a-2 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
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BLAST of slc18a-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
slc18a3b3.137e-1225.00solute carrier family 18 member 3b [Source:NCBI ge... [more]
slc18a3a3.152e-1226.70solute carrier family 18 member A3 [Source:NCBI ge... [more]
slc18a23.466e-819.82synaptic vesicular amine transporter [Source:NCBI ... [more]
SLC18A16.918e-628.66solute carrier family 18 member A1 [Source:NCBI ge... [more]
SLC18A17.287e-628.66solute carrier family 18 member A1 [Source:NCBI ge... [more]
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BLAST of slc18a-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
slc18a3a1.478e-1523.54solute carrier family 18 member 3a [Source:NCBI ge... [more]
slc18a24.431e-720.88solute carrier family 18 member 2 [Source:ZFIN;Acc... [more]
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BLAST of slc18a-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of slc18a-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of slc18a-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
slc18a3a5.866e-1327.12solute carrier family 18 member 3a [Source:NCBI ge... [more]
slc18a3b1.445e-1226.14probable vesicular acetylcholine transporter-B [So... [more]
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BLAST of slc18a-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000041557.10.000e+099.16SMESG000041557.1[more]
SMESG000041535.13.381e-14956.95SMESG000041535.1[more]
SMESG000069017.18.687e-13349.10SMESG000069017.1[more]
SMESG000064367.13.180e-10143.56SMESG000064367.1[more]
SMESG000041534.14.708e-9760.00SMESG000041534.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30001666
GenBankAKN21536.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001666 ID=SMED30001666|Name=slc18a-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1678bp
ACATGATCAATCAAGGAAGGAATTATTAATTATACTGCTACACAACATTC
GCCTTACATCGCCTTTCATATTCCTGTCAACTCTAGTGCAACACAAATAG
ACCAATGAAATTCAATTTAAAATTTAGGTTATATTATGTCTTTTAAATGT
GATGATTGTTTGGCAGCAATTGTAATATGCCTAAACTTTTATATGCTGGG
TATTCAAGAAAGCAGTTTATATACGATATTGCCAAAGTATTTGGTCGACG
AACCATTCAATGCAACAAATAATGAGACATTCAAGCCCAATACAAGTCGT
ACTATATTCCAATGTCATTTGCAAAAGCCTCCATATTTTATTGTTAGTAT
GATATTCCTGTCTAAAAGTCTCGCTCAATTCTTTTTCAATTCCATTATAG
GTTGCTTCGTGGATAAAGTGAATAATTTTATTATTTTATTAATCGGTCAA
GGTCTTGGAATTATAATCGCGTTGATTTATGCATTGAATAATTCTATTAC
AATGTATATCGTTGGGCGGCTATTGGATGCCTTTGTGAGTTGCTCTTTAT
TTATCGGTGGTTTTTCAATTGTTTCAAAATTATTTAGTAACGTTAATACT
AGAGGACGATTTTTCGGTTTGGGTAACACTTTGTATTTTGTCAGTCATTC
TATTGGACCAGTTTATGGCGCTGAAGTTGATGTAAGACTGGGAAAATCAG
CAGTTTTCTTTTTACTAATACCCTTATGGATTTTTACCATGGCAGCCACA
TTTATACTCTACCGACGTACAGAGAAACGATGTAACAAATCCAAGAATAA
TTTCAATGAAAAACTTTCAATCGGTGTAACTCCAGATGAAACGAATGAAT
TAGATGACCATAATGAATTGAAAGTAGCAATTATTATTTCTTCCAATTCT
AAAATGCCTGAAAAATATTCTGATTTCAAAGGAGAAAAAAAATTCCAAAA
AGAAAACAATGAGATTTTTATGAAATTTTATAAAATAATGAAAAATCCTT
ACGTTTCATCGTGTCTTTGTCAACTATTCATTGTTAATCTCAGTATGTTT
GCGTTGCCAGCTACACTGCCTTCATGGATGGGGTTTCGACTGTGCGCAAC
GGAAATCCAACAAGGATTGGTTTGGGCGTTTGGATTTATTGGATATGTGA
GTGGGGTTGGATTGATTGTACTGTTACTAAAGTGTGCGTATCAGCTGCGC
TTTTTTTCACCAATAATAGCGCAGATAATCGTTGGAATTTTATTGATTCT
ATTGCCGCTCAGTCACGATTGGCGCTTGCTATTCATTCCGATAATCGGCA
TGTATTTCAGTGTTGGCGTCATTGAGCAAGTGCTTTTTCCATTGACAACA
TATCTGGCCGATCATCACTTCAATTCCGATTACGGCTCGATGGCATCTTT
AACATCTCAATCTCTTACACTTAGTGGAGTAGTTGGAACCTTATCAAGTG
GCCCAATTGCACAGAGATTTGGGTTTCGGTCTTTGTGCATCTGTTTAGGA
ATCCTTAATTTATTATTTTGTCTTTTATCATTACCCCATCAAAAATTGGT
GCAGTCTTAACAGTAAATATTAAATTAAAATTTATTAACATGTGGCAATT
TATTCACTGTTGCAATATTATTATCAAATCAGGAATGGCTCCAATTTTAA
TTTATTCAACCACTGTTAATTGAAATAA
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protein sequence of SMED30001666-orf-1

>SMED30001666-orf-1 ID=SMED30001666-orf-1|Name=SMED30001666-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=475bp
MSFKCDDCLAAIVICLNFYMLGIQESSLYTILPKYLVDEPFNATNNETFK
PNTSRTIFQCHLQKPPYFIVSMIFLSKSLAQFFFNSIIGCFVDKVNNFII
LLIGQGLGIIIALIYALNNSITMYIVGRLLDAFVSCSLFIGGFSIVSKLF
SNVNTRGRFFGLGNTLYFVSHSIGPVYGAEVDVRLGKSAVFFLLIPLWIF
TMAATFILYRRTEKRCNKSKNNFNEKLSIGVTPDETNELDDHNELKVAII
ISSNSKMPEKYSDFKGEKKFQKENNEIFMKFYKIMKNPYVSSCLCQLFIV
NLSMFALPATLPSWMGFRLCATEIQQGLVWAFGFIGYVSGVGLIVLLLKC
AYQLRFFSPIIAQIIVGILLILLPLSHDWRLLFIPIIGMYFSVGVIEQVL
FPLTTYLADHHFNSDYGSMASLTSQSLTLSGVVGTLSSGPIAQRFGFRSL
CICLGILNLLFCLLSLPHQKLVQS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0022857transmembrane transporter activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000099neuron
PLANA:0000418head
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036259MFS_trans_sf
IPR011701MFS
IPR020846MFS_dom
Vocabulary: biological process
TermDefinition
GO:0055085transmembrane transport
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011701Major facilitator superfamilyPFAMPF07690MFS_1coord: 19..434
e-value: 2.1E-23
score: 82.8
NoneNo IPR availablePANTHERPTHR23506FAMILY NOT NAMEDcoord: 68..466
NoneNo IPR availableCDDcd17384MFS_SLC18A1_2_VAT1_2coord: 70..456
e-value: 8.57694E-18
score: 82.6202
NoneNo IPR availableTMHMMTMhelixcoord: 9..31
NoneNo IPR availableTMHMMTMhelixcoord: 355..377
NoneNo IPR availableTMHMMTMhelixcoord: 326..348
NoneNo IPR availableTMHMMTMhelixcoord: 95..117
NoneNo IPR availableTMHMMTMhelixcoord: 445..467
NoneNo IPR availableTMHMMTMhelixcoord: 381..403
NoneNo IPR availableTMHMMTMhelixcoord: 188..210
NoneNo IPR availableTMHMMTMhelixcoord: 159..178
NoneNo IPR availableTMHMMTMhelixcoord: 124..146
NoneNo IPR availableTMHMMTMhelixcoord: 289..311
NoneNo IPR availableTMHMMTMhelixcoord: 66..88
IPR036259MFS transporter superfamilySUPERFAMILYSSF103473MFS general substrate transportercoord: 12..467