Serine/threonine-protein kinase PDIK1L
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001580 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Match: A0A1I8HD51 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 97.8265 bits (242), Expect = 1.334e-18 Identity = 71/205 (34.63%), Postives = 109/205 (53.17%), Query Frame = 2 Query: 422 PVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWT---VTFSPPSNGLPRQSSPWRVPTIHNHSQLAQKWTPTEKHLENNLH--------FLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENW----QKLFDYRNKLKKKSDEFREKYNGNKR 991 PVD D A +FP TLG + + QI + +TFSPP +GLP PWR+ T HN + HL + L + T T E ++ P+ EL++LR+ RLR+E+E+L+EVKRQ++LE P+ +W+ELR +FHYEA KNN+L++ +L ++R +L S++F+E ++ R Sbjct: 281 PVDFDPLAAVHFPATLGASYRLREQIEAAGTAGTADPRLTFSPPGSGLPYPPDPWRLRTPHNADDFVPTFRSVGDHLADALPAARQQRQLLMAETAPDTAAAEVFVSL--PYSVELARLRMQRLRIEEELLLEVKRQQQLEETAPPKSKWFELRTPQFHYEAHKNNQLVRGGAELPEFDDQLLEFRRQLASSSEKFKETFDAYAR 483
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Match: A0A1I8HHG3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 97.8265 bits (242), Expect = 1.492e-18 Identity = 71/205 (34.63%), Postives = 109/205 (53.17%), Query Frame = 2 Query: 422 PVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWT---VTFSPPSNGLPRQSSPWRVPTIHNHSQLAQKWTPTEKHLENNLH--------FLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENW----QKLFDYRNKLKKKSDEFREKYNGNKR 991 PVD D A +FP TLG + + QI + +TFSPP +GLP PWR+ T HN + HL + L + T T E + +P+ EL++LR+ RLR+E+E+L+EVKRQ++LE P+ +W+ELR +FHYEA KNN+L++ +L ++R +L S++F+E ++ R Sbjct: 285 PVDFDPLAAVHFPATLGASYRLREQIEAAGTAGTADPRLTFSPPGSGLPYPPDPWRLRTPHNADDFVPTFRSVGDHLADALPAARQQRQLLMAETAPGTAAAEVF--VSSPYSVELARLRMQRLRIEEELLLEVKRQQQLEETAPPKRKWFELRTPQFHYEAHKNNQLVRGGTELPEFDDQLLEFRRQLASSSEKFKETFDAYAR 487
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Match: R7T9B2 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_225498 PE=4 SV=1) HSP 1 Score: 90.1225 bits (222), Expect = 1.611e-18 Identity = 51/86 (59.30%), Postives = 70/86 (81.40%), Query Frame = 2 Query: 710 IQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENWQKLFDYRNKLKKKSDEFR 967 + +P+ +EL++LR++RLR+E+E L+E+KRQEELERIRGP P+WYELR FHYEA KN LLKS +NWQ L DYR ++++ S E+R Sbjct: 14 LSSPYQSELARLRMERLRIEEEHLLELKRQEELERIRGPSPKWYELRSPHFHYEAHKNTSLLKSKDNWQMLMDYRTEMERASKEYR 99
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Match: A0A1I8HMZ4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 97.4413 bits (241), Expect = 2.000e-18 Identity = 71/205 (34.63%), Postives = 109/205 (53.17%), Query Frame = 2 Query: 422 PVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWT---VTFSPPSNGLPRQSSPWRVPTIHNHSQLAQKWTPTEKHLENNLH--------FLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENW----QKLFDYRNKLKKKSDEFREKYNGNKR 991 PVD D A +FP TLG + + QI + +TFSPP +GLP PWR+ T HN + HL + L + T T E ++ P+ EL++LR+ RLR+E+E+L+EVKRQ++LE P+ +W+ELR +FHYEA KNN+L++ +L ++R +L S++F+E ++ R Sbjct: 290 PVDFDPLAAVHFPATLGASYRLREQIEAAGTAGTADPRLTFSPPGSGLPYPPDPWRLRTPHNADDFVPTFRSVGDHLADALPAARQQRQLLMAETAPDTAAAEVFVSL--PYSVELARLRMQRLRIEEELLLEVKRQQQLEETAPPKSKWFELRTPQFHYEAHKNNQLVRGGAELPEFDDQLLEFRRQLASSSEKFKETFDAYAR 492
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Match: A0A267G5H6 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig032068g3 PE=4 SV=1) HSP 1 Score: 95.5153 bits (236), Expect = 4.133e-18 Identity = 71/205 (34.63%), Postives = 109/205 (53.17%), Query Frame = 2 Query: 422 PVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWT---VTFSPPSNGLPRQSSPWRVPTIHNHSQLAQKWTPTEKHLENNLH--------FLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENW----QKLFDYRNKLKKKSDEFREKYNGNKR 991 PVD D A +FP TLG + + QI + +TFSPP +GLP PWR+ T HN + HL + L + T T E + +P+ EL++LR+ RLR+E+E+L+EVKRQ++LE P+ +W+ELR +FHYEA KNN+L++ +L ++R +L S++F+E ++ R Sbjct: 171 PVDFDPLAAVHFPATLGASYRLREQIEAAGTAGTADPRLTFSPPGSGLPYPPDPWRLRTPHNADDFVPTFRSVGDHLADALPAARQQRQLLMAETAPGTAAAEVF--VSSPYSVELARLRMQRLRIEEELLLEVKRQQQLEETAPPKRKWFELRTPQFHYEAHKNNQLVRGGTELPEFDDQLLEFRRQLASSSEKFKETFDAYAR 373
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Nematostella
Match: EDO41087 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5A6]) HSP 1 Score: 68.9366 bits (167), Expect = 3.272e-13 Identity = 44/109 (40.37%), Postives = 68/109 (62.39%), Query Frame = 2 Query: 617 KWTPTEKHLENNLHFLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENWQKLFDYRNKL 943 + TP + E ++ L L+ + TP+ EL++L++ L+L++E L++ K +ELERIRGP+PRWYEL+ FH EARKNN+LL S ++ ++ YRN L Sbjct: 179 RQTPVD---EFDMSVFRDAEEHMLSSRTLSGLSTPYRGELAQLKVKGLKLQEERLLKKKCLDELERIRGPKPRWYELKGPDFHREARKNNDLLSQSGHYDEIMQYRNTL 284
BLAST of Serine/threonine-protein kinase PDIK1L vs. Planmine SMEST
Match: SMESG000059621.1 (SMESG000059621.1) HSP 1 Score: 588.186 bits (1515), Expect = 0.000e+0 Identity = 301/302 (99.67%), Postives = 301/302 (99.67%), Query Frame = 2 Query: 116 MSNKDFNDLYVIGKSPFLSEIEDEYTKTDYHRKCIGNGMLLNHKLCDNEMYIPRSNSCWFLNDYHINKDLKFYQSLKALDKLGKQINLLKYDNCEKEIDIITPVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWTVTFSPPSNGLPRQSSPWRVPTIHNHSQLAQKWTPTEKHLENNLHFLESTNNSTLDYERLAAIQTPFHAXXXXXXXXXXXXXXXXXMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENWQKLFDYRNKLKKKSDEFREKYNGNKRYDPTNYIPVL 1021 MSNKDFNDLYVIGKSPFLSEIEDEYTKTDYHRKCIGNGMLLNHKLCDNEMYIPRSNSCWFLNDYHINKDLKFYQSLKALDKLGKQINLLKYDNCEKEIDIITPVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWTVTFSPPSNGLPRQSSPWRVPTIHNHSQL QKWTPTEKHLENNLHFLESTNNSTLDYERLAAIQTPFHAELSKLRLDRLRLEDEILMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENWQKLFDYRNKLKKKSDEFREKYNGNKRYDPTNYIPVL Sbjct: 1 MSNKDFNDLYVIGKSPFLSEIEDEYTKTDYHRKCIGNGMLLNHKLCDNEMYIPRSNSCWFLNDYHINKDLKFYQSLKALDKLGKQINLLKYDNCEKEIDIITPVDVDEAAKKYFPVTLGKACEVNAQINCDKSPPWTVTFSPPSNGLPRQSSPWRVPTIHNHSQLTQKWTPTEKHLENNLHFLESTNNSTLDYERLAAIQTPFHAELSKLRLDRLRLEDEILMEVKRQEELERIRGPEPRWYELRDARFHYEARKNNELLKSSENWQKLFDYRNKLKKKSDEFREKYNGNKRYDPTNYIPVL 302 The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Serine/threonine-protein kinase PDIK1L vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Serine/threonine-protein kinase PDIK1L vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001580 ID=SMED30001580|Name=Serine/threonine-protein kinase PDIK1L|organism=Schmidtea mediterranea sexual|type=transcript|length=1112bpback to top protein sequence of SMED30001580-orf-1 >SMED30001580-orf-1 ID=SMED30001580-orf-1|Name=SMED30001580-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=303bp MSNKDFNDLYVIGKSPFLSEIEDEYTKTDYHRKCIGNGMLLNHKLCDNEMback to top Annotated Terms
The following terms have been associated with this transcript:
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