ADF-H domain-containing protein

Overview


Name	ADF-H domain-containing protein
Smed ID	SMED30001490
Length (bp)	507

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of ADF-H domain-containing protein (SMED30001490) t-SNE clustered cells

Violin plots show distribution of expression levels for ADF-H domain-containing protein (SMED30001490) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of ADF-H domain-containing protein (SMED30001490) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for ADF-H domain-containing protein (SMED30001490) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001490

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30001490	h1SMcG0011896	Contig513	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30001490	h1SMcG0011896	Contig513	GPL15192	PMID:23079596 Forsthoefel et al., 2012
pharynx	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30001490	h1SMcG0011896	dd_Smed_v4_260_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30001490	h1SMcG0011896	Contig48957	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30001490	h1SMcG0011896	Contig48957	newmark_ests	PMID:29674431 Fincher et al., 2018
intestinal phagocyte	SMED30001490	h1SMcG0011896	dd_Smed_v6_260_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
parenchymal cell	SMED30001490	h1SMcG0011896	dd_Smed_v6_260_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
gut	SMED30001490	h1SMcG0011896	PL030005A10G01	smed_ncbi_20240424	PMID:21664348 Forsthoefel et al., 2011
gut	SMED30001490	h1SMcG0011896	DN290811	smed_ncbi_20240424	PMID:21664348 Forsthoefel et al., 2011

Note: Hover over icons to view figure legend

Homology

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BLAST of ADF-H domain-containing protein vs. Ensembl Human
Match: CFL1 (cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874])

HSP 1 Score: 56.6102 bits (135), Expect = 4.954e-10
Identity = 39/140 (27.86%), Postives = 73/140 (52.14%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLIDVTKKAPRE-------ATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV VS    + + ++K+          ++ + VLF ++E  K  ++  +  +E        T +D  A   +        YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKK--NIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQAN 138

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BLAST of ADF-H domain-containing protein vs. Ensembl Human
Match: CFL1 (cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874])

HSP 1 Score: 56.6102 bits (135), Expect = 6.105e-10
Identity = 41/144 (28.47%), Postives = 72/144 (50.00%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV VS    + + ++K+          ++ + VLF ++E  K I           DV +      T +D  A   +        YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQ------TVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQAN 138

[Close]

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV VS    + + ++K+          ++ + VLF ++E  K I           DV +      T +D  A   +        YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQ------TVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQAN 138

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BLAST of ADF-H domain-containing protein vs. Ensembl Human
Match: CFL1 (cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874])

HSP 1 Score: 54.299 bits (129), Expect = 1.708e-9
Identity = 24/57 (42.11%), Postives = 40/57 (70.18%), Query Frame = 2

Query:  203 YAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:   65 YALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQAN 121

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Human
Match: CFL1 (cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874])

HSP 1 Score: 53.9138 bits (128), Expect = 3.616e-9
Identity = 24/57 (42.11%), Postives = 40/57 (70.18%), Query Frame = 2

Query:  203 YAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:   65 YALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQAN 121

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BLAST of ADF-H domain-containing protein vs. Ensembl Celegans
Match: unc-60 (Actin-depolymerizing factor 2, isoform c [Source:UniProtKB/Swiss-Prot;Acc:Q07749])

HSP 1 Score: 64.3142 bits (155), Expect = 1.848e-13
Identity = 39/129 (30.23%), Postives = 68/129 (52.71%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGL-YAVYEYELSEKN---------SQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIK 358
            M++GV V P+C  AY  +    ++ Y++F I + D  I V K   + A Y +FV ++ +     K   YA  + E++ +          +++IFV + PD  PVR +MLYA S   L+  L G++++ +
Sbjct:    1 MASGVKVDPSCKNAYDLLHNKHQHSYIIFKIDKNDTAIVVEKVGEKNAPYAEFVEEMKKLVEDGKECRYAAVDVEVTVQRQGAEGTSTLNKVIFVQYCPDNAPVRRRMLYASSVRALKASL-GLESLFQ 128

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BLAST of ADF-H domain-containing protein vs. Ensembl Celegans
Match: F53E2.2 (Actin-depolymerizing factor 1, isoforms a/b [Source:UniProtKB/Swiss-Prot;Acc:Q07750])

HSP 1 Score: 50.8322 bits (120), Expect = 2.788e-8
Identity = 35/133 (26.32%), Postives = 65/133 (48.87%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRK-YRYVLFGITEGDKLID--VTKKA----------PREATYEDFVADLNEACAQ-NKGLYAVYEYELS--------EKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQL 334
            MS+GV+V P+   ++ ++  GRK YRY++F I E   +++  VT+              +A ++ FV D+           YAV++++ +         K  ++IF+   PD   ++ KM+YA S   ++  L
Sbjct:    1 MSSGVMVDPDVQTSFQKLSEGRKEYRYIIFKIDENKVIVEAAVTQDQLGITGDDYDDSSKAAFDKFVEDVKSRTDNLTDCRYAVFDFKFTCSRVGAGTSKMDKIIFLQICPDGASIKKKMVYASSAAAIKTSL 133

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Query:    2 MSTGVVVSPNCAEAYGEIKMGRK-YRYVLFGITEGDKLID--VTKKA----------PREATYEDFVADLNEACAQ-NKGLYAVYEYELS--------EKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQL 334
            MS+GV+V P+   ++ ++  GRK YRY++F I E   +++  VT+              +A ++ FV D+           YAV++++ +         K  ++IF+   PD   ++ KM+YA S   ++  L
Sbjct:    1 MSSGVMVDPDVQTSFQKLSEGRKEYRYIIFKIDENKVIVEAAVTQDQLGITGDDYDDSSKAAFDKFVEDVKSRTDNLTDCRYAVFDFKFTCSRVGAGTSKMDKIIFLQICPDGASIKKKMVYASSAAAIKTSL 133

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BLAST of ADF-H domain-containing protein vs. Ensembl Fly
Match: tsr (gene:FBgn0011726 transcript:FBtr0072188)

HSP 1 Score: 89.7373 bits (221), Expect = 4.116e-23
Identity = 48/132 (36.36%), Postives = 75/132 (56.82%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYEL---------SEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDV 370
            M++GV VS  C   Y EIK  +K+RYV+F I + +K IDV   A R A Y+ F+ D+ + C   +  Y ++++E          S K  +L  + W PD   V+ KMLY+ S + L+K L+G++  I+A D+
Sbjct:    1 MASGVTVSDVCKTTYEEIKKDKKHRYVIFYIRD-EKQIDVETVADRNAEYDQFLEDI-QKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDL 130

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BLAST of ADF-H domain-containing protein vs. Ensembl Fly
Match: CG6873 (gene:FBgn0030951 transcript:FBtr0074607)

HSP 1 Score: 74.7146 bits (182), Expect = 2.398e-17
Identity = 38/131 (29.01%), Postives = 74/131 (56.49%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEK---------NSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            M++G+ +S  C   + +I+  +++RY +F + + ++ I V     REA Y+DF+ADL  A   N+  +AVY+YE   +           +LI ++W P +  ++ KMLY+ +   L+++  G++  I+A +
Sbjct:    1 MASGINLSRECQHVFEQIRKLKQHRYAVF-VIQDEREIKVEVLGVREANYDDFLADLQRA-GSNQCRFAVYDYEYQHQCQGTLSTCLKEKLILMLWCPTLARIKDKMLYSSTFAVLKREFPGVQKCIQATE 129

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BLAST of ADF-H domain-containing protein vs. Ensembl Zebrafish
Match: cfl1 (cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215])

HSP 1 Score: 53.1434 bits (126), Expect = 6.241e-9
Identity = 38/142 (26.76%), Postives = 69/142 (48.59%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM----------GRKYRYVLFGITEGDKLIDVTK-----KAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V       + E+K+           ++ + V+F +++  K I + +     +      Y  FV  L      N   YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVEETVLTVFNEMKVRKAHCNEEEKSKRKKAVMFCLSDDKKHIIMEQGQEILQGDEGDPYLKFVKML----PPNDCRYALYDATYETKETKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGMD 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Zebrafish
Match: cfl2 (cofilin 2 (muscle) [Source:ZFIN;Acc:ZDB-GENE-040426-1815])

HSP 1 Score: 52.373 bits (124), Expect = 1.157e-8
Identity = 40/147 (27.21%), Postives = 72/147 (48.98%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNE------AC-----AQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV VS    + + ++K+          ++ + VLF +++  K I V      E   +  V D+ +      AC       N   Y +Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVSDEVIKVFNDMKVRKSSSSDEVKKRKKAVLFCLSDDKKKIIV------EEGRQILVGDIGDSVDDPYACFVKLLPLNDCRYGLYDATYETKESKKEDLVFIFWAPEGAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

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BLAST of ADF-H domain-containing protein vs. Ensembl Zebrafish
Match: cfl1l (cofilin 1 (non-muscle), like [Source:ZFIN;Acc:ZDB-GENE-040426-2770])

HSP 1 Score: 45.4394 bits (106), Expect = 4.919e-6
Identity = 23/58 (39.66%), Postives = 36/58 (62.07%), Query Frame = 2

Query:  203 YAVYEYELSEKNS---QLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            YA+Y+ + + K S    L+F+   PD  P+R+KMLYA S+  L+ +L G+K   + ND
Sbjct:   79 YALYDCKYTNKESVKEDLVFIFSAPDDAPMRSKMLYASSKNALKAKLPGMKFEWQIND 136

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BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Match: zc4h2 (zinc finger, C4H2 domain containing [Source:Xenbase;Acc:XB-GENE-941217])

HSP 1 Score: 56.9954 bits (136), Expect = 3.537e-10
Identity = 43/148 (29.05%), Postives = 72/148 (48.65%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIK---------MGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQ--------------NKGLY-AVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V+    + + E+K         + ++ + VLF ++   K I V      E T +  V D+ EA                   GLY A YE + S+K   L+F+ W PD  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVNDEVIKVFNEMKVRKSSTPEEIKKRKKAVLFCLSPDKKEIIV------EETKQILVGDIGEAVPDPYRTFVNLLPLDDCRYGLYDATYETKESKK-EDLVFIFWAPDNAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

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BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Match: zc4h2 (zinc finger, C4H2 domain containing [Source:Xenbase;Acc:XB-GENE-941217])

HSP 1 Score: 51.9878 bits (123), Expect = 1.800e-8
Identity = 40/123 (32.52%), Postives = 62/123 (50.41%), Query Frame = 2

Query:   50 EIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQ--------------NKGLY-AVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            EIK  ++ + VLF ++   K I V      E T +  V D+ EA                   GLY A YE + S+K   L+F+ W PD  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:   11 EIK--KRKKAVLFCLSPDKKEIIV------EETKQILVGDIGEAVPDPYRTFVNLLPLDDCRYGLYDATYETKESKKE-DLVFIFWAPDNAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 124

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BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Match: oat.2 (ornithine aminotransferase, gene 2 [Source:Xenbase;Acc:XB-GENE-1005707])

HSP 1 Score: 50.447 bits (119), Expect = 8.634e-8
Identity = 40/144 (27.78%), Postives = 73/144 (50.69%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV+VS +  + + ++K+          ++ + V+F ++E  K+I           DV      +  Y+ FV  L     +N   YA+Y+  YE  E K   L+FV W P+   +++KM+YA S++ ++K+  GIK   + N
Sbjct:    1 MASGVMVSDDVIKVFNDMKVRHQLSPEEAKKRKKAVVFCLSEDKKMIILEPGKEILQGDVGCNV--DDPYKAFVKML----PRNDCRYALYDALYETKETKKEDLVFVFWAPEEASLKSKMIYASSKDAIKKRFPGIKHEWQTN 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Match: oat.2 (ornithine aminotransferase, gene 2 [Source:Xenbase;Acc:XB-GENE-1005707])

HSP 1 Score: 48.521 bits (114), Expect = 5.528e-7
Identity = 39/143 (27.27%), Postives = 72/143 (50.35%), Query Frame = 2

Query:    5 STGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            ++GV+VS +  + + ++K+          ++ + V+F ++E  K+I           DV      +  Y+ FV  L     +N   YA+Y+  YE  E K   L+FV W P+   +++KM+YA S++ ++K+  GIK   + N
Sbjct:    1 ASGVMVSDDVIKVFNDMKVRHQLSPEEAKKRKKAVVFCLSEDKKMIILEPGKEILQGDVGCNV--DDPYKAFVKML----PRNDCRYALYDALYETKETKKEDLVFVFWAPEEASLKSKMIYASSKDAIKKRFPGIKHEWQTN 137

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BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Match: slc1a2 (solute carrier family 1 member 2 [Source:Xenbase;Acc:XB-GENE-1005169])

HSP 1 Score: 45.4394 bits (106), Expect = 5.769e-6
Identity = 30/108 (27.78%), Postives = 54/108 (50.00%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRY-VLFGITEGDKLIDVTKKAPREATYE---DFVADLNEACAQNKGLYAVYEYELSEKNS---QLIFVVWIPDVIPVRAKMLYA 304
            M++GV V       + E+K+ +  +  + F  TE ++ I + K+  +E   +   DF  +L     + K  YA+ +   S   S   +L+F++W PD   ++ KMLYA
Sbjct:    1 MASGVRVDDCINLQFQEMKLRKSNKKAIFFCFTEDERFITLDKE--KEILVDQKGDFFQNLKALFPEKKCCYALVDVSFSTVESAKEELLFIMWTPDCASIKQKMLYA 106

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BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Match: Cfl1 (cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:101757])

HSP 1 Score: 55.4546 bits (132), Expect = 9.549e-10
Identity = 42/144 (29.17%), Postives = 74/144 (51.39%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV VS    + + ++K+          ++ + VLF ++E  K I           DV +    +  Y  FV  L +   +    YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTV--DDPYTTFVKMLPDKDCR----YALYDATYETKESKKEDLVFIFWAPENAPLKSKMIYASSKDAIKKKLTGIKHELQAN 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Match: Cfl1 (cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:101757])

HSP 1 Score: 55.4546 bits (132), Expect = 2.162e-9
Identity = 42/144 (29.17%), Postives = 74/144 (51.39%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            M++GV VS    + + ++K+          ++ + VLF ++E  K I           DV +    +  Y  FV  L +   +    YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L GIK  ++AN
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTV--DDPYTTFVKMLPDKDCR----YALYDATYETKESKKEDLVFIFWAPENAPLKSKMIYASSKDAIKKKLTGIKHELQAN 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Match: Cfl2 (cofilin 2, muscle [Source:MGI Symbol;Acc:MGI:101763])

HSP 1 Score: 53.9138 bits (128), Expect = 3.738e-9
Identity = 37/142 (26.06%), Postives = 73/142 (51.41%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIK---------MGRKYRYVLFGITEGDKLIDVTKKAPR------EATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V+    + + ++K         + ++ + VLF +++  + I + ++A +        T ED      +    N   YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQI-IVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

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BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Match: Cfl1 (cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:101757])

HSP 1 Score: 48.9062 bits (115), Expect = 3.073e-7
Identity = 38/136 (27.94%), Postives = 68/136 (50.00%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLI-----------DVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIG 340
            M++GV VS    + + ++K+          ++ + VLF ++E  K I           DV +    +  Y  FV  L +   +    YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+L G
Sbjct:    1 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTV--DDPYTTFVKMLPDKDCR----YALYDATYETKESKKEDLVFIFWAPENAPLKSKMIYASSKDAIKKKLTG 130

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BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Match: Dstn (destrin [Source:MGI Symbol;Acc:MGI:1929270])

HSP 1 Score: 48.521 bits (114), Expect = 3.268e-7
Identity = 21/57 (36.84%), Postives = 37/57 (64.91%), Query Frame = 2

Query:  203 YAVYEYELSEKNS---QLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            YA+Y+     K S   +L+F +W P+  P+++KM+YA S++ ++K+  GIK   +AN
Sbjct:   82 YALYDASFETKESRKEELMFFLWAPEQAPLKSKMIYASSKDAIKKKFPGIKHEYQAN 138

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BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9HF97|COFI_ZYGRO (Cofilin OS=Zygosaccharomyces rouxii OX=4956 GN=cof1 PE=2 SV=1)

HSP 1 Score: 96.2857 bits (238), Expect = 1.086e-24
Identity = 47/125 (37.60%), Postives = 78/125 (62.40%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELS-----EKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            +GV V+    +A+ ++K+G+KY++VL+GI+E DK   V K+     +Y++F+  L E    N  LYA+Y++E        K S+++F  W PD  PVR+KM+YA S++ LR+ L G+ + I+  D
Sbjct:    4 SGVSVADESLQAFNDLKLGKKYKFVLYGISE-DKTTIVVKETSTSQSYDEFLGKLPE----NDCLYAIYDFEYEIGGNEGKRSKIVFFTWSPDTAPVRSKMVYASSKDALRRALTGVSSDIQGTD 123

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BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Match: sp|P45594|CADF_DROME (Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster OX=7227 GN=tsr PE=1 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 4.126e-22
Identity = 48/132 (36.36%), Postives = 75/132 (56.82%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYEL---------SEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDV 370
            M++GV VS  C   Y EIK  +K+RYV+F I + +K IDV   A R A Y+ F+ D+ + C   +  Y ++++E          S K  +L  + W PD   V+ KMLY+ S + L+K L+G++  I+A D+
Sbjct:    1 MASGVTVSDVCKTTYEEIKKDKKHRYVIFYIRD-EKQIDVETVADRNAEYDQFLEDI-QKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDL 130

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BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Match: sp|Q759P0|COFI_ASHGO (Cofilin OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=COF1 PE=3 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 5.886e-22
Identity = 47/125 (37.60%), Postives = 76/125 (60.80%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVY--EYELSE---KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            +GV V+     A+ ++K+G+KY++VLFG+   DK   + K+   E  Y+ F+    E   ++  LYAVY  EYE+S    K S+++F  W PD  P+R+KM+YA S++ LR+ L G+ + I+  D
Sbjct:    4 SGVAVADESLTAFNDLKLGKKYKFVLFGLN-ADKTSIIVKETSNERDYDVFL----EKLPEDDCLYAVYDFEYEISGAEGKRSKIVFFTWSPDTAPIRSKMVYASSKDALRRALNGVSSDIQGTD 123

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BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Match: sp|P78929|COFI_SCHPO (Cofilin OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cof1 PE=1 SV=1)

HSP 1 Score: 88.5817 bits (218), Expect = 7.913e-22
Identity = 45/123 (36.59%), Postives = 76/123 (61.79%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEK---NSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            +GV VSP C EA+ E+K+G+  RYV+F + +    I V KK+  +  ++ F+ DL E   +    YA+Y++E +      +++IF+ W PDV P+++KM+Y+ S++ LR+   GI   I+A D
Sbjct:    4 SGVKVSPECLEAFQELKLGKSLRYVVFKMNDTKTEIVVEKKST-DKDFDTFLGDLPEKDCR----YAIYDFEFNLGEGVRNKIIFISWSPDVAPIKSKMVYSSSKDTLRRAFTGIGTDIQATD 121

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BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Match: sp|P37167|ACTP_ACACA (Actophorin OS=Acanthamoeba castellanii OX=5755 PE=1 SV=2)

HSP 1 Score: 88.1965 bits (217), Expect = 1.075e-21
Identity = 39/123 (31.71%), Postives = 73/123 (59.35%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQ---LIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            +G+ VS +C + + E+K+G ++RYV F +   +  + V       ATYEDF + L E   +    YA+++YE      Q   + F++W PD  P+++KM+Y  +++ ++K+L+GI+  ++A D
Sbjct:    2 SGIAVSDDCVQKFNELKLGHQHRYVTFKMNASNTEVVVEHVGGPNATYEDFKSQLPERDCR----YAIFDYEFQVDGGQRNKITFILWAPDSAPIKSKMMYTSTKDSIKKKLVGIQVEVQATD 120

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BLAST of ADF-H domain-containing protein vs. TrEMBL
Match: C1L849 (Putative Cofilin-1 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 1.056e-30
Identity = 53/124 (42.74%), Postives = 85/124 (68.55%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            MSTG+    +C EAY ++K+ +KYRY+LF I    + I V  +A REA Y+DF+ DL  A    +G YAVY+YEL EK + ++F++W+P  + V+ +M+YA S+  L+ +L+G+K  ++AND++
Sbjct:    1 MSTGIKCDKSCYEAYEDLKLLKKYRYILFHIYNNQE-IKVLHRAAREANYDDFMQDLITAMNAGEGRYAVYDYELKEKVNSIVFILWVPSSLDVKVRMIYAASKSALKAKLVGVKYEVEANDLE 123

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BLAST of ADF-H domain-containing protein vs. TrEMBL
Match: A0A2H1CVR1 (Cofilin/tropomyosin-type actin-binding protein OS=Fasciola hepatica OX=6192 GN=D915_00759 PE=3 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 1.820e-29
Identity = 52/124 (41.94%), Postives = 83/124 (66.94%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++G+  S  C +A+ ++K  + +RY+L+ I + DK I V+ +A R AT+ DF+ DL  A  + K LYAVY+YE   K   L+F+VW P  I +R KM+YA S + ++++LIG+K  I+A+D+D
Sbjct:    1 MASGIKCSDTCVDAFNDMKFRKTHRYILYEICD-DKEIRVSYRAKRSATFSDFIQDLVSARKEKKALYAVYDYESPGKMPYLVFIVWTPTDIEIRKKMIYAASTDAIKRKLIGLKTTIQAHDLD 123

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BLAST of ADF-H domain-containing protein vs. TrEMBL
Match: A0A504Z805 (Putative Cofilin actophorin OS=Fasciola gigantica OX=46835 GN=FGIG_02872 PE=3 SV=1)

HSP 1 Score: 113.235 bits (282), Expect = 5.109e-29
Identity = 52/124 (41.94%), Postives = 83/124 (66.94%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++G+  S  C +A+ ++K  + +RY+L+ I + DK I V+ +A R AT+ DF+ DL  A  + K LYAVY+YE   K   L+F+VW P  I +R KM+YA S + ++++LIG+K  I+A+D+D
Sbjct:    1 MASGIKCSDTCVDAFNDMKFRKTHRYILYEICD-DKEIRVSYRAKRSATFGDFIQDLVSARKEKKALYAVYDYESPGKMPYLVFIVWTPTDIEIRKKMIYAASTDAIKRKLIGLKTTIQAHDLD 123

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BLAST of ADF-H domain-containing protein vs. TrEMBL
Match: A0A4V3SGQ5 (ADF-H domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001624 PE=3 SV=1)

HSP 1 Score: 113.62 bits (283), Expect = 5.220e-29
Identity = 54/124 (43.55%), Postives = 83/124 (66.94%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV    +C +AY E+K+ + +RY+LF I   ++ I V +KA R ATYEDF  DL  A  + +G YAVY+YE+  K   LIF+ W P  + ++ K++YA S++ +R +LIGIK  ++AND+D
Sbjct:    1 MASGVKCHQSCIDAYNELKLRKNHRYILFHIRNNEE-IQVLRKADRNATYEDFYQDLITAMDEGEGRYAVYDYEVPGKLPTLIFISWNPSPLSIKTKLIYAASKDAIRLKLIGIKHEVEANDID 123

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BLAST of ADF-H domain-containing protein vs. TrEMBL
Match: A0A504Y8J6 (Putative actin-depolymerizing factor OS=Fasciola gigantica OX=46835 GN=FGIG_03015 PE=3 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 6.924e-29
Identity = 55/124 (44.35%), Postives = 82/124 (66.13%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV    +C +AY E+K+ + +RY+LF I   ++ I V + A R ATYE+FV +L +A    +G YAV++YE   K   LIFV+W P  +  R KMLYA S++ +R +LIGIK  ++AND+D
Sbjct:    1 MASGVKCHQSCIDAYNELKLRKNWRYILFHIKNNEE-IQVLRTADRSATYENFVDELTDAENLGQGRYAVFDYECPGKLPTLIFVLWNPSSLTTRTKMLYAASKDAIRLKLIGIKHEVEANDLD 123

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BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
Match: cfl1l (cofilin-2-like [Source:NCBI gene;Acc:103024737])

HSP 1 Score: 54.299 bits (129), Expect = 2.040e-9
Identity = 38/136 (27.94%), Postives = 70/136 (51.47%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM-------GRKYRYVLFGITEGDKLIDVTKKAP---REATYEDFV-ADLNEACAQNKGLYAVYE--YELSEK-NSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            M++GV +S    E Y +I++         +++ V+  ++E  K I V  ++    ++   ED V   +     +    YA+Y+  YE  E     L+F++W P+  P+++KM+YA S+  LR +L G+K   + ND
Sbjct:    1 MASGVAISDEVVEHYTKIRVRYQGSEEKERFKIVIMRMSEDQKSIIVDHESSLKVKDVEKEDNVFKKILSTLPEKDCRYALYDCTYETKESLKEDLVFIMWAPEDAPLKSKMVYASSKGALRSKLPGLKFEWQVND 136

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BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
Match: cfl1 (cofilin-2 [Source:NCBI gene;Acc:103047533])

HSP 1 Score: 53.1434 bits (126), Expect = 5.510e-9
Identity = 40/146 (27.40%), Postives = 72/146 (49.32%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGR----------KYRYVLFGIT---------EGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V  N    + E+K+ +          + + VLF ++         EG++++   +  P    Y  FV  L      +   YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVEENVLTIFNEMKVRKAQANEEERRKRKKAVLFCLSDDKKKIVMEEGNEILQGDEGDP----YLKFVKML----PPDDCRYALYDATYETKETKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 138

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BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
Match: cfl2 (cofilin 2 [Source:NCBI gene;Acc:103041014])

HSP 1 Score: 51.9878 bits (123), Expect = 1.373e-8
Identity = 40/147 (27.21%), Postives = 72/147 (48.98%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNE------AC-----AQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V+    + + ++K+          ++ + VLF +++  K I V      E   +  V D+ E      AC       N   Y +Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVNDEVIKVFNDMKVRKSSTSDEVKKRKKAVLFCLSDDKKKIIV------EEGKQILVGDIGETVDDPYACFVKLLPLNDCRYGLYDATYETKESKKEDLVFIFWAPEGAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
Match: cfl1 (cofilin-2 [Source:NCBI gene;Acc:103047533])

HSP 1 Score: 51.2174 bits (121), Expect = 4.196e-8
Identity = 23/60 (38.33%), Postives = 39/60 (65.00%), Query Frame = 2

Query:  203 YAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:  106 YALYDATYETKETKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 165

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Sea Lamprey
Match: cfl1 (cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215])

HSP 1 Score: 55.0694 bits (131), Expect = 2.271e-10
Identity = 46/149 (30.87%), Postives = 77/149 (51.68%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGI---------TEGDKLI--DV--TKKAPREATYEDFVADLNEACAQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV+VS +  + +  +K+          ++ + VLF I          EG +++  DV  T K P    Y+ FV  L     ++   YA+Y+  YE  E K   L+F+ W PD  P+++KM+YA S+E ++K+  GIK   + N +D
Sbjct:    1 MASGVLVSDDVVQIFNNMKVRKSSTPEEVKKRKKAVLFCIGPDMRNIIAEEGKEILVGDVGETVKDP----YDTFVKLL----PKDDCRYALYDATYETRETKKEDLVFIFWAPDGAPLKSKMVYASSKEAIKKKFTGIKHEWQVNGLD 141

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BLAST of ADF-H domain-containing protein vs. Ensembl Sea Lamprey
Match: cfl2 (cofilin 2 (muscle) [Source:ZFIN;Acc:ZDB-GENE-040426-1815])

HSP 1 Score: 54.6842 bits (130), Expect = 2.760e-10
Identity = 39/143 (27.27%), Postives = 69/143 (48.25%), Query Frame = 2

Query:    5 STGVVVSPNCAEAYGEIK---------MGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQ-----------NKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            ++GV VS +    + ++K         + ++ + VLF +++  + I V      E + +  V D+ E               N   YA+Y+  YE  E K   L+FV W PD  P+++KM+YA S++ ++K+  GIK   + N
Sbjct:    2 ASGVSVSDDVIRVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIV------ETSRQILVGDIGETVEDPYGAFVKLLPLNDCRYALYDATYETRESKKEDLVFVFWAPDSAPLKSKMIYASSKDAIKKKFTGIKHEWQVN 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007240.1 (pep scaffold:Pmarinus_7.0:GL476479:38272:39885:-1 gene:ENSPMAG00000006535.1 transcript:ENSPMAT00000007240.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.299 bits (129), Expect = 3.952e-10
Identity = 40/143 (27.97%), Postives = 69/143 (48.25%), Query Frame = 2

Query:    5 STGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEAC-----------AQNKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            ++GV VS +    + ++K+          ++ + VLF ++   K I V      E   E  V D+ ++              N   YA+Y+  YE +E K   L+FV W PD  P+++KM+YA S++ ++K+  GIK   + N
Sbjct:    2 ASGVAVSDDVIRVFNDMKVRKASSAEEVKKRKKAVLFCLSPDKKQIIV------EPAKEILVGDIGQSVDDPYGAFVKLLPPNDCRYALYDATYETNESKKEDLVFVFWAPDSAPLKSKMIYASSKDAIKKKFTGIKHEWQVN 138

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Yeast
Match: COF1 (Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes [Source:SGD;Acc:S000003973])

HSP 1 Score: 88.1965 bits (217), Expect = 2.355e-23
Identity = 42/125 (33.60%), Postives = 74/125 (59.20%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELS-----EKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAND 367
            +GV V+     A+ ++K+G+KY+++LFG+ +    I V K+   + +Y+ F+    E   +N  LYA+Y++E        K S+++F  W PD  PVR+KM+YA S++ LR+ L G+   ++  D
Sbjct:    4 SGVAVADESLTAFNDLKLGKKYKFILFGLNDAKTEI-VVKETSTDPSYDAFL----EKLPENDCLYAIYDFEYEINGNEGKRSKIVFFTWSPDTAPVRSKMVYASSKDALRRALNGVSTDVQGTD 123

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Nematostella
Match: EDO45331 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT59])

HSP 1 Score: 48.1358 bits (113), Expect = 3.426e-7
Identity = 33/114 (28.95%), Postives = 57/114 (50.00%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQ---LIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIG 340
            TG+  S +    +   K G   R +  GI E ++LI +T   P++    D+   +     + +  Y +Y   L  KN+Q    +F+ + PD  P+R KML+AG++  L+K+  G
Sbjct:    5 TGIQASEDLKSVFARSKDG-DIRMIKVGI-ENEELICITTTEPKKDWERDYDDAVVRHLEEKQPCYILYR--LDSKNNQGYEWLFIAYSPDFSPIRQKMLFAGTRATLKKEFGG 114

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Nematostella
Match: EDO43372 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYS8])

HSP 1 Score: 44.2838 bits (103), Expect = 3.021e-6
Identity = 28/137 (20.44%), Postives = 67/137 (48.91%), Query Frame = 2

Query:    8 TGVVVSPNCAEAYGEIKMGRK------YRYVLFGITEGDKLIDVTKK------APREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQL----IFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDV 370
            +G+ ++  C E + ++K+  K      ++Y +F +++ +  +++ +K      A      E+   +L    ++ +  + +Y+     K+  L    IF+ W  D  P++ KML   + E L+K+  G+K   +A+++
Sbjct:    6 SGIEMTEECIELFKDMKITTKGADRPRFKYAIFKLSDDNTKVELEEKVEAKCLANNREEDEEIFEELKGKLSKKEPRFILYDMRFCSKSGSLKEILIFIKWCSDEAPIKKKMLAGSTWEYLKKKFDGLKKYFEASEI 142

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
Match: cfl2 (cofilin-2 [Source:NCBI gene;Acc:101159957])

HSP 1 Score: 53.5286 bits (127), Expect = 4.007e-9
Identity = 39/147 (26.53%), Postives = 70/147 (47.62%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM---------GRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQ-----------NKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV V+      + ++K+          ++ + V+F ++E  K I V      E   +  V D+ E               N   YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:    1 MASGVTVTDEVIRVFNDMKVRKSSTQDEVKKRKKAVMFCMSEDKKNIIV------EDGKQILVGDIGETVDDPYLCFVKLLPPNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
Match: cfl2 (cofilin-2 [Source:NCBI gene;Acc:101159957])

HSP 1 Score: 51.2174 bits (121), Expect = 2.988e-8
Identity = 24/64 (37.50%), Postives = 40/64 (62.50%), Query Frame = 2

Query:  191 NKGLYAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            N   YA+Y+  YE  E K   L+F+ W P+  P+++KM+YA S++ ++K+  GIK   + N +D
Sbjct:   78 NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLD 141

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000014865.2 (cofilin-2 [Source:NCBI gene;Acc:101164501])

HSP 1 Score: 49.6766 bits (117), Expect = 1.100e-7
Identity = 37/136 (27.21%), Postives = 63/136 (46.32%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKM-------GRKYRYVLFGITEGDKLIDVTKKAPREATY--EDFVADLNEACAQNKGLYAVYEYELSEKNS----QLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDV 370
            M++GV V  +      E+K+         + R V+  I +G     V +K  RE     +D           ++  Y +Y+     K S    +L+FV+W P+   ++ KM YA S++ L+K L GIK  ++ ND+
Sbjct:    1 MASGVQVHDDVKTIMDEMKVVKADSDQNERIRLVVLEIKDG---FIVIEKVLREKDLANQDVFKQFLSLLEPSRCCYILYDCHFETKESSRKEELVFVMWAPETGHIKEKMRYASSKDSLKKILTGIKHELQMNDL 133

[Close]

BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
Match: cfl1 (cofilin 1 [Source:NCBI gene;Acc:101173715])

HSP 1 Score: 49.2914 bits (116), Expect = 1.580e-7
Identity = 22/57 (38.60%), Postives = 37/57 (64.91%), Query Frame = 2

Query:  203 YAVYE--YELSE-KNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKAN 364
            YA+Y+  YE  E K   L+F+ W PD  P+++KM+YA S++ ++++  GIK   + N
Sbjct:   83 YALYDATYETKETKKEDLVFIFWAPDSAPLKSKMIYASSKDAIKRKFEGIKHEWQVN 139

[Close]

BLAST of ADF-H domain-containing protein vs. Planmine SMEST
Match: SMESG000080129.1 (SMESG000080129.1)

HSP 1 Score: 255.373 bits (651), Expect = 1.495e-88
Identity = 124/124 (100.00%), Postives = 124/124 (100.00%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD
Sbjct:    1 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 124

[Close]

BLAST of ADF-H domain-containing protein vs. Planmine SMEST
Match: SMESG000022423.1 (SMESG000022423.1)

HSP 1 Score: 67.781 bits (164), Expect = 7.996e-15
Identity = 36/124 (29.03%), Postives = 68/124 (54.84%), Query Frame = 2

Query:    2 MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATYEDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIKAVIKANDVD 373
            M++GV   P+  E    IK+  K++Y+++G+ +    I   +       YE F   + E  A+ +G YA+Y+Y+       L F+ WIP+ + + ++M+ A S+  +  +++G+KA I+AN  D
Sbjct:    1 MASGVKCDPSVEEYLNYIKLQHKFQYIIYGLNQQKDRIIKLETGELGTPYEVFRKHMIETYAK-EGCYALYDYQ-----GTLAFISWIPETMKINSRMIMAASKSEIATRMVGVKAKIEANSED 118

[Close]

BLAST of ADF-H domain-containing protein vs. Planmine SMEST
Match: SMESG000045466.1 (SMESG000045466.1)

HSP 1 Score: 53.9138 bits (128), Expect = 4.791e-10
Identity = 21/53 (39.62%), Postives = 36/53 (67.92%), Query Frame = 2

Query:  188 QNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIK 346
            +  G YA+++Y L  K   LIF+ WIP  +PV+ +M+ A S++ ++K+L GI+
Sbjct:    5 KKDGAYAIFDYPLENKGDLLIFICWIPIDLPVKKRMILASSKDAIKKKLKGIR 57

[Close]

BLAST of ADF-H domain-containing protein vs. Planmine SMEST
Match: SMESG000045466.1 (SMESG000045466.1)

HSP 1 Score: 53.5286 bits (127), Expect = 5.350e-10
Identity = 21/53 (39.62%), Postives = 36/53 (67.92%), Query Frame = 2

Query:  188 QNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLYAGSQEGLRKQLIGIK 346
            +  G YA+++Y L  K   LIF+ WIP  +PV+ +M+ A S++ ++K+L GI+
Sbjct:    7 KKDGAYAIFDYPLENKGDLLIFICWIPIDLPVKKRMILASSKDAIKKKLKGIR 59

The following BLAST results are available for this feature:

BLAST of ADF-H domain-containing protein vs. Ensembl Human
BLAST of ADF-H domain-containing protein vs. Ensembl Celegans
BLAST of ADF-H domain-containing protein vs. Ensembl Fly
BLAST of ADF-H domain-containing protein vs. Ensembl Zebrafish
BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
BLAST of ADF-H domain-containing protein vs. TrEMBL
BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
BLAST of ADF-H domain-containing protein vs. Ensembl Sea Lamprey
BLAST of ADF-H domain-containing protein vs. Ensembl Yeast
BLAST of ADF-H domain-containing protein vs. Ensembl Nematostella
BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
BLAST of ADF-H domain-containing protein vs. Planmine SMEST

BLAST of ADF-H domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CFL1	4.954e-10	27.86	cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]	[more]
CFL1	6.105e-10	28.47	cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]	[more]
CFL1	6.105e-10	28.47	cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]	[more]
CFL1	1.708e-9	42.11	cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]	[more]
CFL1	3.616e-9	42.11	cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
unc-60	1.848e-13	30.23	Actin-depolymerizing factor 2, isoform c [Source:...	[more]
F53E2.2	2.788e-8	26.32	Actin-depolymerizing factor 1, isoforms a/b [Sour...	[more]
F53E2.2	2.788e-8	26.32	Actin-depolymerizing factor 1, isoforms a/b [Sour...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
tsr	4.116e-23	36.36	gene:FBgn0011726 transcript:FBtr0072188	[more]
CG6873	2.398e-17	29.01	gene:FBgn0030951 transcript:FBtr0074607	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
cfl1	6.241e-9	26.76	cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215]	[more]
cfl2	1.157e-8	27.21	cofilin 2 (muscle) [Source:ZFIN;Acc:ZDB-GENE-04042...	[more]
cfl1l	4.919e-6	39.66	cofilin 1 (non-muscle), like [Source:ZFIN;Acc:ZDB-...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
zc4h2	3.537e-10	29.05	zinc finger, C4H2 domain containing [Source:Xenbas...	[more]
zc4h2	1.800e-8	32.52	zinc finger, C4H2 domain containing [Source:Xenbas...	[more]
oat.2	8.634e-8	27.78	ornithine aminotransferase, gene 2 [Source:Xenbase...	[more]
oat.2	5.528e-7	27.27	ornithine aminotransferase, gene 2 [Source:Xenbase...	[more]
slc1a2	5.769e-6	27.78	solute carrier family 1 member 2 [Source:Xenbase;A...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cfl1	9.549e-10	29.17	cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:1...	[more]
Cfl1	2.162e-9	29.17	cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:1...	[more]
Cfl2	3.738e-9	26.06	cofilin 2, muscle [Source:MGI Symbol;Acc:MGI:10176...	[more]
Cfl1	3.073e-7	27.94	cofilin 1, non-muscle [Source:MGI Symbol;Acc:MGI:1...	[more]
Dstn	3.268e-7	36.84	destrin [Source:MGI Symbol;Acc:MGI:1929270]	[more]

BLAST of ADF-H domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9HF97\|COFI_ZYGRO	1.086e-24	37.60	Cofilin OS=Zygosaccharomyces rouxii OX=4956 GN=cof...	[more]
sp\|P45594\|CADF_DROME	4.126e-22	36.36	Cofilin/actin-depolymerizing factor homolog OS=Dro...	[more]
sp\|Q759P0\|COFI_ASHGO	5.886e-22	37.60	Cofilin OS=Ashbya gossypii (strain ATCC 10895 / CB...	[more]
sp\|P78929\|COFI_SCHPO	7.913e-22	36.59	Cofilin OS=Schizosaccharomyces pombe (strain 972 /...	[more]
sp\|P37167\|ACTP_ACACA	1.075e-21	31.71	Actophorin OS=Acanthamoeba castellanii OX=5755 PE=...	[more]

BLAST of ADF-H domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C1L849	1.056e-30	42.74	Putative Cofilin-1 OS=Schistosoma japonicum OX=618...	[more]
A0A2H1CVR1	1.820e-29	41.94	Cofilin/tropomyosin-type actin-binding protein OS=...	[more]
A0A504Z805	5.109e-29	41.94	Putative Cofilin actophorin OS=Fasciola gigantica ...	[more]
A0A4V3SGQ5	5.220e-29	43.55	ADF-H domain-containing protein OS=Opisthorchis fe...	[more]
A0A504Y8J6	6.924e-29	44.35	Putative actin-depolymerizing factor OS=Fasciola g...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
cfl1l	2.040e-9	27.94	cofilin-2-like [Source:NCBI gene;Acc:103024737]	[more]
cfl1	5.510e-9	27.40	cofilin-2 [Source:NCBI gene;Acc:103047533]	[more]
cfl2	1.373e-8	27.21	cofilin 2 [Source:NCBI gene;Acc:103041014]	[more]
cfl1	4.196e-8	38.33	cofilin-2 [Source:NCBI gene;Acc:103047533]	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
cfl1	2.271e-10	30.87	cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215]	[more]
cfl2	2.760e-10	27.27	cofilin 2 (muscle) [Source:ZFIN;Acc:ZDB-GENE-04042...	[more]
ENSPMAT00000007240.1	3.952e-10	27.97	pep scaffold:Pmarinus_7.0:GL476479:38272:39885:-1 ...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
COF1	2.355e-23	33.60	Cofilin, involved in pH-dependent actin filament d...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO45331	3.426e-7	28.95	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43372	3.021e-6	20.44	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of ADF-H domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
cfl2	4.007e-9	26.53	cofilin-2 [Source:NCBI gene;Acc:101159957]	[more]
cfl2	2.988e-8	37.50	cofilin-2 [Source:NCBI gene;Acc:101159957]	[more]
ENSORLT00000014865.2	1.100e-7	27.21	cofilin-2 [Source:NCBI gene;Acc:101164501]	[more]
cfl1	1.580e-7	38.60	cofilin 1 [Source:NCBI gene;Acc:101173715]	[more]

BLAST of ADF-H domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000080129.1	1.495e-88	100.00	SMESG000080129.1	[more]
SMESG000022423.1	7.996e-15	29.03	SMESG000022423.1	[more]
SMESG000045466.1	4.791e-10	39.62	SMESG000045466.1	[more]
SMESG000045466.1	5.350e-10	39.62	SMESG000045466.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30001490 ID=SMED30001490|Name=ADF-H domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=507bp
AATGTCTACTGGAGTTGTCGTGTCGCCGAATTGTGCTGAAGCATATGGAG
AAATAAAAATGGGACGAAAGTACAGATATGTACTTTTTGGTATTACAGAG
GGAGATAAATTAATTGATGTGACTAAAAAAGCTCCTCGAGAAGCAACATA
TGAAGACTTTGTGGCTGATTTAAATGAGGCTTGTGCGCAGAATAAAGGTT
TATATGCCGTTTATGAATACGAATTATCTGAAAAGAATAGCCAGCTGATT
TTTGTTGTATGGATTCCAGATGTTATTCCAGTAAGAGCCAAAATGTTATA
TGCTGGCTCGCAAGAAGGATTAAGAAAACAACTAATTGGCATAAAAGCTG
TTATTAAAGCTAATGATGTTGATGAAATCAGTAAGGAAGAAATTGAAGCC
AAACTAAAATGATTGAAATTTAATGGTACTTATGTGAAACAAATGAAGAG
TTTGCTGTTTTCTATGATCGTTTTTTAATTAAATACATTTTGAACATAAT
AATAAAA

protein sequence of SMED30001490-orf-1

>SMED30001490-orf-1 ID=SMED30001490-orf-1|Name=SMED30001490-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=137bp
MSTGVVVSPNCAEAYGEIKMGRKYRYVLFGITEGDKLIDVTKKAPREATY
EDFVADLNEACAQNKGLYAVYEYELSEKNSQLIFVVWIPDVIPVRAKMLY
AGSQEGLRKQLIGIKAVIKANDVDEISKEEIEAKLK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **molecular function**
Term	Definition
GO:0003779	actin binding

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0015629	actin cytoskeleton

Vocabulary: **INTERPRO**
Term	Definition
IPR017904	ADF/Cofilin
IPR002108	ADF-H
IPR029006	ADF-H/Gelsolin-like_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0030042	actin filament depolymerization

Main menu

ADF-H domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Owlery

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