Serine/threonine-protein kinase ULK2

Overview
NameSerine/threonine-protein kinase ULK2
Smed IDSMED30001480
Length (bp)886
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine/threonine-protein kinase ULK2 (SMED30001480) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine/threonine-protein kinase ULK2 (SMED30001480) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine/threonine-protein kinase ULK2 (SMED30001480) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine/threonine-protein kinase ULK2 (SMED30001480) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30001480

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 21

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30001480h1SMcG0000019 Contig1746GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30001480h1SMcG0000019 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30001480h1SMcG0018370 dd_Smed_v4_1196_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Match: ULK1 (unc-51 like autophagy activating kinase 1 [Source:HGNC Symbol;Acc:HGNC:12558])

HSP 1 Score: 140.198 bits (352), Expect = 1.327e-36
Identity = 88/271 (32.47%), Postives = 142/271 (52.40%), Query Frame = 3 
Query:  105 TMRIGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE-LQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            T  +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  I+ FL QI   +  +++K I+HRDLKP+NIL+ N  G+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+ L+  ++  K                      + N+K R   ++  +HPF+
Sbjct:    8 TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Match: ULK2 (unc-51 like autophagy activating kinase 2 [Source:HGNC Symbol;Acc:HGNC:13480])

HSP 1 Score: 134.42 bits (337), Expect = 1.132e-34
Identity = 78/207 (37.68%), Postives = 121/207 (58.45%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVG 704
            +G++EY   + +G G F VV++GR+  +T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K   SE  I+ FLHQI A +  +++K I+HRDLKP+NIL+     +      I  KI DFG +R++   +   T  G+  YMAPEV  +   +   D++S+G VI + LVG
Sbjct:    4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG 210
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Match: ULK2 (unc-51 like autophagy activating kinase 2 [Source:HGNC Symbol;Acc:HGNC:13480])

HSP 1 Score: 134.42 bits (337), Expect = 1.132e-34
Identity = 78/207 (37.68%), Postives = 121/207 (58.45%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVG 704
            +G++EY   + +G G F VV++GR+  +T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K   SE  I+ FLHQI A +  +++K I+HRDLKP+NIL+     +      I  KI DFG +R++   +   T  G+  YMAPEV  +   +   D++S+G VI + LVG
Sbjct:    4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG 210
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 120.553 bits (301), Expect = 1.005e-31
Identity = 76/251 (30.28%), Postives = 132/251 (52.59%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVK-VPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSA-GTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN---------------IKNA-------SPELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            E +GEG FG VYKGR   +   VA+K +PK         + +REI +++ L H NI+ +L S E D ++++V +Y  +G+L + +    +  E +++A   Q+++ L Y+++  I+HRD+KP+NIL+   GG    K+ DFG +R +      +TS  GT  YM+PE+      +   D++S+G IL +L  G                +K+        SP  +N  + +  ++ ++R    D+  HPF+
Sbjct:    8 EMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGG---IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Match: DAPK2 (death associated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:2675])

HSP 1 Score: 120.168 bits (300), Expect = 7.115e-31
Identity = 76/211 (36.02%), Postives = 118/211 (55.92%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAAS------ETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITY-KITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKNASPEL 734
            Y+ G E LG G F +V K R   TG E A K  K     AS      E  +RE+++L+ + H N+ITL    E    ++L+LE    G+L +F+ +K   SE E  +F+ QIL G+ Y++ K I H DLKP+NI+++++   I + K+ DFG++  +E  + +    GT +++APE+ N        D++S+GVI   L+ G    ASP L
Sbjct:   23 YDIGEE-LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG----ASPFL 228
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Match: unc-51 (Serine/threonine-protein kinase unc-51 [Source:UniProtKB/Swiss-Prot;Acc:Q23023])

HSP 1 Score: 135.961 bits (341), Expect = 1.367e-35
Identity = 92/274 (33.58%), Postives = 135/274 (49.27%), Query Frame = 3 
Query:  123 YEYG-TECLGEGGFGVVYKGRNI-RTGNEVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQG-------GQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN---IKNASPEL-------QNLHKNMKE---------------ENYKKRFQLNDVKNHPFVKN*FL 830
            +EY   + LG G F +VY+GR + RT   VA+K + K     +     +EI +LK LS   H N++ LL   E    + LV+E+C  GDL +++++K   +E  I+ F+ QI   LE IN K IVHRDLKP+NIL+ N           I  K+ DFG +RF+   +   T  G+  YMAPEV  + + +   D++S+G IL   + G    +    P+L       + L  N+ E                N K R    D  NHPF+ +  L
Sbjct:    7 FEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRISFEDFFNHPFLTSPLL 280
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 114.005 bits (284), Expect = 4.852e-28
Identity = 72/236 (30.51%), Postives = 129/236 (54.66%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRAN-KNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLN-DVKN 803
            + +G+Y+   + +G+G F  V   +++ TG+EVA+K+    +   S   K  RE+ ++K L H NI+ L    E +  + LVLEY   G++ +++    +  E E +A   QI++ ++Y+++K+I+HRDLK +N+L+      +  KI DFG S          T  G+  Y APE+ +  + +   +D++SLGVIL  LV G++      L+ L + +    Y+  F ++ D +N
Sbjct:  101 VHVGKYKL-LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL---DQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 332
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 114.005 bits (284), Expect = 5.382e-28
Identity = 72/236 (30.51%), Postives = 129/236 (54.66%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRAN-KNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLN-DVKN 803
            + +G+Y+   + +G+G F  V   +++ TG+EVA+K+    +   S   K  RE+ ++K L H NI+ L    E +  + LVLEY   G++ +++    +  E E +A   QI++ ++Y+++K+I+HRDLK +N+L+      +  KI DFG S          T  G+  Y APE+ +  + +   +D++SLGVIL  LV G++      L+ L + +    Y+  F ++ D +N
Sbjct:  101 VHVGKYKL-LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL---DQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 332
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 114.005 bits (284), Expect = 5.382e-28
Identity = 72/236 (30.51%), Postives = 129/236 (54.66%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRAN-KNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLN-DVKN 803
            + +G+Y+   + +G+G F  V   +++ TG+EVA+K+    +   S   K  RE+ ++K L H NI+ L    E +  + LVLEY   G++ +++    +  E E +A   QI++ ++Y+++K+I+HRDLK +N+L+      +  KI DFG S          T  G+  Y APE+ +  + +   +D++SLGVIL  LV G++      L+ L + +    Y+  F ++ D +N
Sbjct:  101 VHVGKYKL-LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL---DQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 332
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 114.005 bits (284), Expect = 5.382e-28
Identity = 72/236 (30.51%), Postives = 129/236 (54.66%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRAN-KNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLN-DVKN 803
            + +G+Y+   + +G+G F  V   +++ TG+EVA+K+    +   S   K  RE+ ++K L H NI+ L    E +  + LVLEY   G++ +++    +  E E +A   QI++ ++Y+++K+I+HRDLK +N+L+      +  KI DFG S          T  G+  Y APE+ +  + +   +D++SLGVIL  LV G++      L+ L + +    Y+  F ++ D +N
Sbjct:  101 VHVGKYKL-LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL---DQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 332
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Match: Atg1 (gene:FBgn0260945 transcript:FBtr0075945)

HSP 1 Score: 133.265 bits (334), Expect = 1.470e-34
Identity = 79/210 (37.62%), Postives = 117/210 (55.71%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGNEVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGG-------QITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
            +GEYEY + + LG G F VVYKGR+ +    VA+K + K           +EI +LK L+   H N++ LL  +E    + LV+EYC  GDL +++  K   SE  ++ FL Q+   ++ +  K IVHRDLKP+NIL+ +  G       +IT KI DFG +RF+       T  G+  YMAPEV  + + +   D++SLG I+   + G
Sbjct:    4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTG 213
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Match: Atg1 (gene:FBgn0260945 transcript:FBtr0300561)

HSP 1 Score: 133.265 bits (334), Expect = 1.687e-34
Identity = 79/210 (37.62%), Postives = 117/210 (55.71%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGNEVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGG-------QITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
            +GEYEY + + LG G F VVYKGR+ +    VA+K + K           +EI +LK L+   H N++ LL  +E    + LV+EYC  GDL +++  K   SE  ++ FL Q+   ++ +  K IVHRDLKP+NIL+ +  G       +IT KI DFG +RF+       T  G+  YMAPEV  + + +   D++SLG I+   + G
Sbjct:    4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTG 213
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0302950)

HSP 1 Score: 119.398 bits (298), Expect = 1.865e-30
Identity = 70/191 (36.65%), Postives = 104/191 (54.45%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVK--VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPE-VKNNTRANKNIDIYSLGVILEDLVGG 707
            LGEG +GVVYK R+  TG  VAVK  V      A  +   REI LLK L H N+++LL    +  ++ LV E+C+   LHE  R  +   E   K   +Q L G+ Y + +  +HRD+KP+NIL+  QG     K+ DFG +R +    +Y     T  Y APE +  +T+    +D++++G +  +LV G
Sbjct:   53 LGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQG---QVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRG 240
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343389)

HSP 1 Score: 119.013 bits (297), Expect = 1.979e-30
Identity = 70/191 (36.65%), Postives = 104/191 (54.45%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVK--VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPE-VKNNTRANKNIDIYSLGVILEDLVGG 707
            LGEG +GVVYK R+  TG  VAVK  V      A  +   REI LLK L H N+++LL    +  ++ LV E+C+   LHE  R  +   E   K   +Q L G+ Y + +  +HRD+KP+NIL+  QG     K+ DFG +R +    +Y     T  Y APE +  +T+    +D++++G +  +LV G
Sbjct:   39 LGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQG---QVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRG 226
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343388)

HSP 1 Score: 119.013 bits (297), Expect = 2.008e-30
Identity = 70/191 (36.65%), Postives = 104/191 (54.45%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVK--VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPE-VKNNTRANKNIDIYSLGVILEDLVGG 707
            LGEG +GVVYK R+  TG  VAVK  V      A  +   REI LLK L H N+++LL    +  ++ LV E+C+   LHE  R  +   E   K   +Q L G+ Y + +  +HRD+KP+NIL+  QG     K+ DFG +R +    +Y     T  Y APE +  +T+    +D++++G +  +LV G
Sbjct:   30 LGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQG---QVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRG 217
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 137.117 bits (344), Expect = 2.783e-38
Identity = 87/268 (32.46%), Postives = 141/268 (52.61%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASP-ELQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            IG+YE+   + +G G F VV+KGR+ +  N EVAVK     + A S++   +EI +LK L H NI++LL  +E  G + LV+EYC  GDL E++  K   SE  I+  L Q+   +  + +K I+HRDLKP+NIL+    G+      I  K+ DFG +R+++      T  G+  YMAPEV  +   +   D++S+G I+   + G    + ++P EL+  ++  +                      + N ++R   +D  +HPF+
Sbjct:    4 IGKYEFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAKSQSLLGKEIKILKELKHENIVSLLDFQEISGCVYLVMEYCNGGDLAEYLHSKGCLSEDTIRVLLQQLAGAMSVLRSKGIIHRDLKPQNILLSYSTGRKSNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNYDAKADLWSVGTIIYQCLTGKAPFQASTPQELRQFYERNRSLSPSIPRETSSHLRHLLLGLLQRNQRERIDFDDFFHHPFL 271
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Match: ulk2 (unc-51 like autophagy activating kinase 2 [Source:ZFIN;Acc:ZDB-GENE-090218-30])

HSP 1 Score: 139.428 bits (350), Expect = 1.641e-36
Identity = 90/269 (33.46%), Postives = 143/269 (53.16%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIR-TGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVGG-----------------------NI-KNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            +G++EY   + +G G F VV+KGR+ + T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K    E  ++ FL QI A +  +N+K I+HRDLKP+NIL+   G +      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G VI + LVG                        NI +  SP+L++L   + + N K R   +   +HPF++
Sbjct:    4 VGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQETPSSVFLVMEYCNGGDLADYLQAKGTLREDTLRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKKSSINGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKSLVPNIPRETSPQLEDLLLGLLQRNQKDRIDFDTFFSHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 138.658 bits (348), Expect = 2.810e-36
Identity = 87/269 (32.34%), Postives = 142/269 (52.79%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASP-ELQNLHKNMK----------------------EENYKKRFQLNDVKNHPFVK 818
            IG+YE+   + +G G F VV+KGR+ +  N EVAVK     + A S++   +EI +LK L H NI++LL  +E  G + LV+EYC  GDL E++  K   SE  I+  L Q+   +  + +K I+HRDLKP+NIL+    G+      I  K+ DFG +R+++      T  G+  YMAPEV  +   +   D++S+G I+   + G    + ++P EL+  ++  +                      + N ++R   +D  +HPF++
Sbjct:    4 IGKYEFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAKSQSLLGKEIKILKELKHENIVSLLDFQEISGCVYLVMEYCNGGDLAEYLHSKGCLSEDTIRVLLQQLAGAMSVLRSKGIIHRDLKPQNILLSYSTGRKSNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNYDAKADLWSVGTIIYQCLTGKAPFQASTPQELRQFYERNRSLSPSIPRETSSHLRHLLLGLLQRNQRERIDFDDFFHHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:ZFIN;Acc:ZDB-GENE-071203-2])

HSP 1 Score: 136.732 bits (343), Expect = 1.480e-35
Identity = 86/269 (31.97%), Postives = 138/269 (51.30%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITY------KITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFVK 818
            +G++E+   + +G G F VV+KGR+      EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++  K   SE  I+ FL QI   +  +  K I+HRDLKP+NIL+ +  G+ ++      KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         + L  N+  E               N+K R   ++   HPF++
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHREKHEWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQITGAMRVLQAKGIIHRDLKPQNILLSHPAGRKSHFNNTCIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKTLSPNIPRETSTHLRHLLLGLLQRNHKDRMDFDEFFRHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Match: sik2b (salt-inducible kinase 2b [Source:ZFIN;Acc:ZDB-GENE-071012-1])

HSP 1 Score: 127.872 bits (320), Expect = 1.463e-32
Identity = 79/225 (35.11%), Postives = 121/225 (53.78%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEV-KNNTRANKNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYK 773
            +R+G Y+     LG+G F VV   R+  T  EVA+K+       A   +K  RE+ ++K L H +II L    E    + LV EY K+G++ +++ K  + SEPE +    QIL+ +EY +N++IVHRDLK +N+L+    G +  KI DFG   F +      T  G+  Y APEV +        +DI+S+GV+L  LV G +    P L  L + + E  ++
Sbjct:   17 VRVGFYDI-ERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNIVHRDLKAENLLL---DGHMNIKIADFGFGNFFQSGKPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPSLPVLRQRVLEGRFR 237
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Match: twnk (twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE-978896])

HSP 1 Score: 143.28 bits (360), Expect = 9.198e-38
Identity = 89/268 (33.21%), Postives = 142/268 (52.99%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFV 815
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  I+ FL QI   ++ +++K I+HRDLKP+NIL+   GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N K R + ++  +HPF+
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHKEKQDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQELANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSCSGGRKSNPNNIRIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQASSPQDLRLFYEKNKNLTPNIPRETSCHLKQLLLGLLQRNQKDRMEFDEFFHHPFL 271
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Match: ULK2 (unc-51 like autophagy activating kinase 2 [Source:NCBI gene;Acc:100487396])

HSP 1 Score: 133.65 bits (335), Expect = 2.221e-34
Identity = 90/268 (33.58%), Postives = 139/268 (51.87%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVGGNIKNA-SPELQNL----HKNM-------------------KEENYKKRFQLNDVKNHPFV 815
            +G++EY   + +G G F VV+KGR+  +T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+E+C  GDL ++++ K   SE  I+ FL QI A +  +++K I+HRDLKP+NIL+     +      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G VI + LVG     A SP+   L    +KN+                    + N K R       NHPF+
Sbjct:    4 VGDFEYSRKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQEMPNSVFLVMEFCNGGDLADYLQAKGTLSEDTIRIFLQQIAAAMRVLHSKGIIHRDLKPQNILLSYASRKKATFSGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRLFYEKNKNLVPSIPRETSAYLSDLLLALLQRNQKDRLDFEGFFNHPFL 271
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Match: twnk (twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE-978896])

HSP 1 Score: 127.872 bits (320), Expect = 2.307e-32
Identity = 84/268 (31.34%), Postives = 137/268 (51.12%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFV 815
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L++               + LV+EYC  GDL +++   R  SE  I+ FL QI   ++ +++K I+HRDLKP+NIL+   GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N K R + ++  +HPF+
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHKEKQDLEVAVKCINKKNLAKSQTLLGKEIKILKELAN--------------SVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSCSGGRKSNPNNIRIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQASSPQDLRLFYEKNKNLTPNIPRETSCHLKQLLLGLLQRNQKDRMEFDEFFHHPFL 257
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Match: twnk (twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE-978896])

HSP 1 Score: 125.176 bits (313), Expect = 1.843e-31
Identity = 76/217 (35.02%), Postives = 120/217 (55.30%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE 731
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L Y            +YC  GDL +++   R  SE  I+ FL QI   ++ +++K I+HRDLKP+NIL+   GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHKEKQDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVAL-YD----------FQYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSCSGGRKSNPNNIRIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQASSPQ 209
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Match: twnk (twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE-978896])

HSP 1 Score: 125.176 bits (313), Expect = 1.874e-31
Identity = 76/217 (35.02%), Postives = 120/217 (55.30%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE 731
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L Y            +YC  GDL +++   R  SE  I+ FL QI   ++ +++K I+HRDLKP+NIL+   GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHKEKQDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVAL-YD----------FQYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSCSGGRKSNPNNIRIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQASSPQ 209
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Match: Ulk1 (unc-51 like kinase 1 [Source:MGI Symbol;Acc:MGI:1270126])

HSP 1 Score: 141.354 bits (355), Expect = 3.856e-37
Identity = 87/268 (32.46%), Postives = 142/268 (52.99%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE-LQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  ++ FL QI   +  +++K I+HRDLKP+NIL+ N GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+ L+  ++  K                      + N+K R   ++  +HPF+
Sbjct:   11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Match: Ulk1 (unc-51 like kinase 1 [Source:MGI Symbol;Acc:MGI:1270126])

HSP 1 Score: 141.354 bits (355), Expect = 3.862e-37
Identity = 87/268 (32.46%), Postives = 142/268 (52.99%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE-LQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  ++ FL QI   +  +++K I+HRDLKP+NIL+ N GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+ L+  ++  K                      + N+K R   ++  +HPF+
Sbjct:   11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Match: Ulk2 (unc-51 like kinase 2 [Source:MGI Symbol;Acc:MGI:1352758])

HSP 1 Score: 133.265 bits (334), Expect = 2.465e-34
Identity = 80/208 (38.46%), Postives = 121/208 (58.17%), Query Frame = 3 
Query:  114 IGEYEY-GTECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILI-------INQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVG 704
            +G++EY   + +G G F VV++GR+  +T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K   SE  I+ FLHQI A +  +++K I+HRDLKP+NIL+        N  G I  KI DFG +R++       T  G+  YMAPEV  +   +   D++S+G VI + LVG
Sbjct:    4 VGDFEYCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSG-IRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG 210
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Match: Dapk3 (death-associated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1203520])

HSP 1 Score: 122.094 bits (305), Expect = 1.032e-32
Identity = 79/227 (34.80%), Postives = 121/227 (53.30%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVK------VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQ-GGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKNASPEL----QNLHKNMKEENY 770
            YE G E LG G F +V K +   TG E A K      +P    G + E  +RE+++L+ + H NIITL    E    ++L+LE    G+L +F+ +K   +E E   FL QIL G+ Y+++K I H DLKP+NI+++++       K+ DFG++  +E    +    GT +++APE+ N        D++S+GVI   L+ G    ASP L    Q    N+   NY
Sbjct:   13 YEMGEE-LGSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG----ASPFLGETKQETLTNISAVNY 234
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Match: Dapk3 (death-associated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1203520])

HSP 1 Score: 117.857 bits (294), Expect = 9.769e-32
Identity = 68/194 (35.05%), Postives = 108/194 (55.67%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVK------VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQ-GGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGV 683
            YE G E LG G F +V K +   TG E A K      +P    G + E  +RE+++L+ + H NIITL    E    ++L+LE    G+L +F+ +K   +E E   FL QIL G+ Y+++K I H DLKP+NI+++++       K+ DFG++  +E    +    GT +++APE+ N        D++S+GV
Sbjct:   13 YEMGEE-LGSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGV 205
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Match: sp|O70405|ULK1_MOUSE (Serine/threonine-protein kinase ULK1 OS=Mus musculus OX=10090 GN=Ulk1 PE=1 SV=1)

HSP 1 Score: 141.354 bits (355), Expect = 2.697e-36
Identity = 87/268 (32.46%), Postives = 142/268 (52.99%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE-LQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  ++ FL QI   +  +++K I+HRDLKP+NIL+ N GG+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+ L+  ++  K                      + N+K R   ++  +HPF+
Sbjct:   11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Match: sp|O75385|ULK1_HUMAN (Serine/threonine-protein kinase ULK1 OS=Homo sapiens OX=9606 GN=ULK1 PE=1 SV=2)

HSP 1 Score: 140.198 bits (352), Expect = 6.372e-36
Identity = 88/271 (32.47%), Postives = 142/271 (52.40%), Query Frame = 3 
Query:  105 TMRIGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE-LQNLHKNMK----------------------EENYKKRFQLNDVKNHPFV 815
            T  +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++   R  SE  I+ FL QI   +  +++K I+HRDLKP+NIL+ N  G+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+ L+  ++  K                      + N+K R   ++  +HPF+
Sbjct:    8 TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Match: sp|Q23023|UNC51_CAEEL (Serine/threonine-protein kinase unc-51 OS=Caenorhabditis elegans OX=6239 GN=unc-51 PE=1 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 1.739e-34
Identity = 92/274 (33.58%), Postives = 135/274 (49.27%), Query Frame = 3 
Query:  123 YEYG-TECLGEGGFGVVYKGRNI-RTGNEVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQG-------GQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN---IKNASPEL-------QNLHKNMKE---------------ENYKKRFQLNDVKNHPFVKN*FL 830
            +EY   + LG G F +VY+GR + RT   VA+K + K     +     +EI +LK LS   H N++ LL   E    + LV+E+C  GDL +++++K   +E  I+ F+ QI   LE IN K IVHRDLKP+NIL+ N           I  K+ DFG +RF+   +   T  G+  YMAPEV  + + +   D++S+G IL   + G    +    P+L       + L  N+ E                N K R    D  NHPF+ +  L
Sbjct:    7 FEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRISFEDFFNHPFLTSPLL 280
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Match: sp|F4JBP3|ATG1B_ARATH (Serine/threonine-protein kinase ATG1b OS=Arabidopsis thaliana OX=3702 GN=ATG1B PE=2 SV=1)

HSP 1 Score: 135.191 bits (339), Expect = 2.488e-34
Identity = 84/264 (31.82%), Postives = 133/264 (50.38%), Query Frame = 3 
Query:  114 IGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPA--SGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG--------------------------NIKNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVKN 821
            IG+Y  G + +G G F VV++GR++  G  VA+K    A  +    E+   EI +L+ ++H NII  +   E  GKI LVLEYCK GDL  +I K     E   K F+ Q+ AGL+ + + +I+HRDLKP+N+L+         KI DFG +R ++      T  G+  YMAPE+    + +   D++S+G IL  LV G                          + ++ S + ++L + +   N  +R    +  +HPF+ +
Sbjct:   17 IGDYAVGRQ-IGSGSFSVVWEGRHLVHGTVVAIKEIAMARLNKKLQESLMSEIIILRKINHPNIIRFIDMIEAPGKINLVLEYCKGGDLSMYIHKHGSVPEATAKHFMLQLAAGLQVLRDNNIIHRDLKPQNLLLSTDDNDAALKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQLVTGRTPFTGNSQIQLLQNIIRSTELHFPADCRDLSTDCKDLCQKLLRRNPVERLTFEEFFHHPFLSD 279
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Match: sp|Q8IYT8|ULK2_HUMAN (Serine/threonine-protein kinase ULK2 OS=Homo sapiens OX=9606 GN=ULK2 PE=1 SV=3)

HSP 1 Score: 134.42 bits (337), Expect = 5.434e-34
Identity = 78/207 (37.68%), Postives = 121/207 (58.45%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVG 704
            +G++EY   + +G G F VV++GR+  +T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K   SE  I+ FLHQI A +  +++K I+HRDLKP+NIL+     +      I  KI DFG +R++   +   T  G+  YMAPEV  +   +   D++S+G VI + LVG
Sbjct:    4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG 210
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Match: A0A1D2N4Y1 (Serine/threonine-protein kinase ULK2 OS=Orchesella cincta OX=48709 GN=Ocin01_06387 PE=4 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 3.514e-37
Identity = 94/269 (34.94%), Postives = 140/269 (52.04%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETD-KREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILII-----NQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG----------NIKN---------------ASPELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            IG+YEY + + +G G F VV+KGRN RT   VA+K     + A S+T   +EIA+LK L+   H N++ L    E    + LV+EYC  GDL +++  K   SE  I+ FL Q+   +  +++K +VHRDLKP+NIL+          +I  KI DFG +RF++  +   T  G+  YMAPEV  +   +   D++SLG I+   + G           +KN                S EL +L  N+ + N K+R   N   +HPF+
Sbjct:    5 IGDYEYNSKDLIGHGAFAVVFKGRNKRTAQCVAIKSITKKNLAKSQTLLTKEIAILKELTELHHENVVALFECRETSTHVYLVMEYCNGGDLADYLSGKGTLSEDTIRLFLRQLAGAMRALHSKGVVHRDLKPQNILLTYNKPSPSPHEILLKIADFGFARFLQDGVMAATLCGSPMYMAPEVIMSLTYDAKADLWSLGTIVYQCLTGKAPFSAQTPQQLKNFYEKHLVLHPKIPAGTSAELTDLLHNLLKRNPKERIDFNAFFSHPFL 273
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Match: A0A087TZ91 (Serine/threonine-protein kinase ULK2 (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_12219 PE=4 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 4.878e-37
Identity = 93/273 (34.07%), Postives = 145/273 (53.11%), Query Frame = 3 
Query:  111 RIGEYEYGT-ECLGEGGFGVVYKGRNIRTGNEV-AVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQG------GQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNI---------------KNA----------SPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            +IG+YEY T + +G G F +V+KGR+ +  + V A+K VPK   G +     +EI +L+ L+   H N++ LL   +    + +V+EYC  GDL E++  K   SE  I+ FL QI   ++ +N K +VHRDLKP+NIL+ + G       +IT KI DFG +RF+   +   T  G+  YMAPEV  + + +   D++S+G I+   + G                 KNA          S EL +L   + + + K R   +++ NHPF+K
Sbjct:    3 KIGDYEYNTKDLIGHGAFAIVFKGRHQKNHDHVVAIKCVPKGKLGKSQPLIGKEIKILQELTKLQHKNVVALLECVDSPKNLYIVIEYCNGGDLSEYLNAKGSLSEDTIRLFLRQIAEAMKVLNQKEVVHRDLKPQNILLCHSGKPNPMPSEITLKIADFGFARFLTDGVMAATLCGSPMYMAPEVIMSLKYDAKADLWSIGTIVYQCLTGKAPFMAPNPQQLKHFYEKNANLAPSIPSGTSQELTDLLIRLMKRDAKDRMDFDELFNHPFLK 275
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Match: K7IRV4 (Protein kinase domain-containing protein OS=Nasonia vitripennis OX=7425 GN=100123698 PE=4 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 7.328e-37
Identity = 94/273 (34.43%), Postives = 145/273 (53.11%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNI-RTGNEVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGG-------QITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNI---------------KNA----------SPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            +G+YEY T + +G G F VV+KGR+  RT   VA+K + K +   +     +EI +LK L+   H N++ LL  +E +  + LV+EYC  GDL +++  K   SE  I+ FL Q+   ++ ++ K +VHRDLKP+NIL+ +  G       QIT KI DFG +RF++  +   T  G+  YMAPEV  + + +   D++SLG I+   + G                 KNA          SPEL NL   +   N + R   ++  +HPF++
Sbjct:    4 VGDYEYNTKDLIGHGAFAVVFKGRHRKRTNFVVAIKSITKKSLAKSQNLLGKEIKILKELTELHHENVVALLDCKESNHNVFLVMEYCNGGDLADYLGAKGTLSEDTIRVFLKQLAGAMKALHAKGVVHRDLKPQNILLSHSCGKMCPQPHQITLKIADFGFARFLQDGVMAATLCGSPMYMAPEVIMSLQYDAKADLWSLGTIVFQCLTGKAPFQAHTPQALKMFYEKNANLGPKIPPGTSPELSNLLMGLLRRNARDRMPFDEFFSHPFLQ 276
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Match: A0A3Q0JT09 (serine/threonine-protein kinase ULK1-like OS=Ciona intestinalis OX=7719 GN=LOC100175789 PE=4 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 2.030e-36
Identity = 90/233 (38.63%), Postives = 138/233 (59.23%), Query Frame = 3 
Query:   99 MLTMR-IGEYEYG-TECLGEGGFGVVYKGRN-IRTGNEVAVK-VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQ-----GGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVIL-EDLVGGNIKNASP--ELQNLHKNMKE 761
            M+TM  IGEYEY   + +G G F +VYKGR+ ++  +EVA+K + K   G A     +EI +LK L H NI+ L   +E    + LV+EYC  GDL E+++ K   SE  I+ FL QI++ +  I++K I+HRDLKP+N+L+ ++        IT KI DFG +R+++      T  G+  YMAPEV  +   +   D++S+G I+ + LVG     AS   EL+N ++  ++
Sbjct:    1 MVTMESIGEYEYNKADHIGHGAFALVYKGRHKVKKHHEVAIKCIDKKKVGRAQTVLDKEIRILKELQHENIVQLYECKESSSSVFLVMEYCNGGDLAEYLQAKGTLSEDTIRMFLQQIVSAMAAIHSKGILHRDLKPQNLLLSHKVPNPRPQDITLKIADFGFARYLQSNAMAATLCGSPMYMAPEVITSQHYDAKADLWSIGTIVYQCLVGKAPFQASTPQELRNFYERNRQ 233
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Match: A0A0L7R8F9 (Serine/threonine-protein kinase ULK2 OS=Habropoda laboriosa OX=597456 GN=WH47_11775 PE=4 SV=1)

HSP 1 Score: 146.747 bits (369), Expect = 6.502e-36
Identity = 92/273 (33.70%), Postives = 144/273 (52.75%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGN-EVAVK-VPKPASGAASETDKREIALLKTLS---HLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGG-------QITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNI---------------KNA----------SPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            IG+YEY T + +G G F VV++GR+ +  N  VA+K + K +   +     +EI +LK L+   H N++ LL  +E +  + LV+EYC  GDL +++  K   SE  I+ FL Q+   ++ ++ K +VHRDLKP+NIL+ +  G       QIT KI DFG +RF++  +   T  G+  YMAPEV  + + +   D++SLG I+   + G                 KNA          SPEL +L   +   N + R   ++   HPF++
Sbjct:    4 IGDYEYNTKDLIGHGAFAVVFRGRHRKKPNFVVAIKSITKKSLAKSQNLLGKEIKILKELTELHHENVVALLDCKESNHNVFLVMEYCNGGDLADYLSAKGTLSEDTIRVFLKQLAGAMKALHAKGVVHRDLKPQNILLSHNCGKACPQPHQITLKIADFGFARFLQDGVMAATLCGSPMYMAPEVIMSLQYDAKADLWSLGTIVFQCLTGKAPFQAHTPQALKLFYEKNANLGPKIPPGTSPELSDLLMGLLRRNARDRMPFDEFFGHPFLQ 276
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:NCBI gene;Acc:103042154])

HSP 1 Score: 141.354 bits (355), Expect = 2.903e-37
Identity = 89/269 (33.09%), Postives = 139/269 (51.67%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITY------KITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFVK 818
            +G++E+   + +G G F VV+KGRN    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++  K   SE  I+ FL QI   +  +  K I+HRDLKP+NIL+ +  G+ T+      KI DFG +R ++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N+K R   ++   HPF++
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRNREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQIAGAMRVLQAKGIIHRDLKPQNILLSHPAGRKTHSNNTCIKIADFGFARHLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSSHLRHLLLGLLQRNHKDRMDFDEFFKHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:NCBI gene;Acc:103042154])

HSP 1 Score: 141.354 bits (355), Expect = 2.919e-37
Identity = 89/269 (33.09%), Postives = 139/269 (51.67%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITY------KITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFVK 818
            +G++E+   + +G G F VV+KGRN    + EVAVK     + A S+T   +EI +LK L H NI+ L   +E    + LV+EYC  GDL +++  K   SE  I+ FL QI   +  +  K I+HRDLKP+NIL+ +  G+ T+      KI DFG +R ++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N+K R   ++   HPF++
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRNREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQIAGAMRVLQAKGIIHRDLKPQNILLSHPAGRKTHSNNTCIKIADFGFARHLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSSHLRHLLLGLLQRNHKDRMDFDEFFKHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Match: ulk2 (unc-51 like autophagy activating kinase 2 [Source:NCBI gene;Acc:103026407])

HSP 1 Score: 137.887 bits (346), Expect = 4.684e-36
Identity = 90/269 (33.46%), Postives = 142/269 (52.79%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIR-TGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVGG-----------------------NI-KNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            +G++EY   + +G G F VV+KGR+ + T  EVA+K     + + S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K    E  ++ FL QI A +  +N+K I+HRDLKP+NIL+   G +      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G VI + LVG                        NI +  SP+L +L   + + N K R   +   +HPF++
Sbjct:    4 VGDFEYSRKDLVGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQETPNFVFLVMEYCNGGDLADYLQAKGTLREDTLRVFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKKSSINGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKTLVPNIPRETSPQLTDLLLGLLQRNQKDRMDFDTFFSHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 129.028 bits (323), Expect = 4.514e-33
Identity = 85/269 (31.60%), Postives = 139/269 (51.67%), Query Frame = 3 
Query:  114 IGEYEYGT-ECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPEL--------QNLHKNMKEE---------------NYKKRFQLNDVKNHPFVK 818
            IG++E+   + +G G F VV++GR+ +  + EVAVK     + A S++   +EI +LK L H NI+ LL     D ++  +  YC  GDL E++  K   SE  I++FL QI A +  +  K I+HRDLKP+NIL+    G+      I  K+ DFG +R+++      T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N++ R   ++  +HPF++
Sbjct:    4 IGKFEFNRKDLIGHGAFAVVFRGRHKQKHDLEVAVKCINKKNLAKSQSLLGKEIKILKELKHENIVGLL-----DFQVCQLQTYCNGGDLAEYLHSKGSLSEDTIRSFLQQIAAAMSVLRCKGIIHRDLKPQNILLTYSSGRRANPNSICVKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSQNYDAKADLWSVGTIIFQCLTGKAPFQASSPQELRQFYERNRNLSPNIPRETSSHLRHLLLSLLQRNHRDRMDFDEFFHHPFLE 267
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Match: sik2b (salt-inducible kinase 2b [Source:ZFIN;Acc:ZDB-GENE-071012-1])

HSP 1 Score: 124.79 bits (312), Expect = 1.579e-31
Identity = 78/236 (33.05%), Postives = 125/236 (52.97%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEV-KNNTRANKNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLNDVKNH 806
            +R+G Y+     LG+G F VV   R+  T  EVA+K+       +   +K  RE+ ++K L H +II L    E    + LV EY K+G++ +++ K  + SEPE +    QIL+ +EY +N+++VHRDLK +N+L+    G +  KI DFG + F        T  G+  Y APEV +        +DI+S+GV+L  LV G +    P L  L + + E  ++  + + +   H
Sbjct:   16 VRVGFYDI-ERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDSVNLEKIYREVKIMKMLDHPHIIKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNVVHRDLKAENLLL---DGHMNIKIADFGFANFFRTGEPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEH 247
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 121.709 bits (304), Expect = 3.702e-31
Identity = 80/251 (31.87%), Postives = 130/251 (51.79%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVK-VPKPA-SGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTS-AGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN----------------------IKNASPELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            E +GEG FG VYKGR   TG  VA+K +PK   S       +REI +++ L H NI+ +L S E D ++++V +Y  +G+L + +       E +++    Q+++ L Y+++  I+HRD+KP+NIL + +GG +  K+ DFG +R +      +TS  GT  YM+PE+      +   D++S+G IL +L  G                        KN S E +N  + +  +  K R     + +HPFV
Sbjct:    8 EMIGEGSFGKVYKGRKRYTGQVVALKFIPKVGRSDKELRNLRREIDIMRGLQHPNIVQMLDSFETDKEVVVVTDYA-EGELFQILEDDGNLPEEQVREIACQLVSALYYLHSHRILHRDMKPQNIL-LGKGGVV--KLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADLWSMGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKWPKNMSSEFRNFLQGLLTKEPKLRLSWPALLHHPFV 254
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001278.1 (pep scaffold:Pmarinus_7.0:GL476529:253165:339525:-1 gene:ENSPMAG00000001147.1 transcript:ENSPMAT00000001278.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 111.694 bits (278), Expect = 3.112e-29
Identity = 71/204 (34.80%), Postives = 108/204 (52.94%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVKVPKPAS------GAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILII-NQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKNASPEL 734
            L  G F VV K    ++G E A K  K         G   E  KRE+++L+ L H NII+L    E D  + L+LE    G+L +F+  K   SE E   FL QIL G+ Y++ + I H DLKP+NI+++ N+  +   KI DFG+++ +   + +    GT +++ PE+ N        D++S+GV+   L+ G    ASP L
Sbjct:    1 LPSGQFAVVKKCCEKKSGLEFAAKFIKKRRSRSSRRGVVPEDIKREVSILRELRHPNIISLHEVYENDTDVTLILELVSGGELFDFLAHKESLSEDEATEFLKQILDGVSYLHCRRIAHFDLKPENIMLLENRAPKAHVKIIDFGLAQSIVDGVEFRHIFGTPEFVVPEIVNYEPLGVQADMWSIGVMTYILLSG----ASPFL 200
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 110.153 bits (274), Expect = 1.219e-28
Identity = 73/195 (37.44%), Postives = 113/195 (57.95%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVK---VPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQF--SEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTL-SYMTSAGTEKYMAPEVKNNTR-ANKNIDIYSLGVILEDLV 701
            E +GEG +GVVYK R+  TG+ VA+K   +     G  S T  REIALL+ L+H NI+ LL     + K+ LV E+  D DL +++        S P +K+++HQ+L G+ + + +  +HRDLKP+N L+IN  G I  K+ DFG++R     L +Y     T  Y APE+    +  +  +D++SLG I  +++
Sbjct:    8 EKIGEGTYGVVYKARHKMTGDTVALKKIRLDTETEGVPS-TAIREIALLRELNHPNIVRLLDVIHSETKLYLVFEFL-DQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQN-LLINADGAI--KLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEML 197
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 112.464 bits (280), Expect = 1.239e-28
Identity = 78/239 (32.64%), Postives = 126/239 (52.72%), Query Frame = 3 
Query:  105 TMRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDK--REIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYM--TSAGTEKYMAPEVKNNTRAN-KNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENYKKRFQLN-DVKN 803
            T R+G Y    + +G+G F  V   ++  TG EVAVK+        S   K  RE+ ++K L+H NI+ L    E +  + LV+EY   G++ +++    +  E E +A   QI++ ++Y + K IVHRDLK +N+L+      +  KI DFG S   E+TL     T  G+  Y APE+    + +   +D++SLGVIL  LV G++      L+ L + +    Y+  F ++ D +N
Sbjct:   62 TQRVGNYRL-LKTIGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQKLFREVRIMKVLNHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLL---DADMNIKIADFGFSN--EFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 294
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Match: snrka (SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040718-84])

HSP 1 Score: 111.694 bits (278), Expect = 5.937e-28
Identity = 77/251 (30.68%), Postives = 124/251 (49.40%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVKV---PKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFI-RKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEV-KNNTRANKNIDIYSLGVILEDLVGG-----------------NIKNASP-----ELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            LG G F VV   R++ TG +VAVKV    K    A S   ++E+  +K + H N++ L    +   K+ L+LE    GDL+++I R +    E   K +  Q++  + Y +   +VHRDLKP+N++   + G +  K+TDFG S   +      TS G+  Y APE+   +      +DI+SLGVIL  LV G                 + K   P     E ++L   M + + ++R  L +++ HP++
Sbjct:   22 LGRGHFAVVKLARHVFTGEKVAVKVIDKSKLDPMATSHLFQQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELADGGDLYDYIMRHEGGLQEELAKTYFAQVVHAISYCHRLHVVHRDLKPENVVFFEKQGLV--KLTDFGFSNLFQPGTKLATSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILYMLVCGHPPFQEANDSETLTMIMDCKYTVPAHISRECKDLIARMLQRDPRRRASLQEMEGHPWL 270
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 119.398 bits (298), Expect = 1.402e-30
Identity = 79/201 (39.30%), Postives = 114/201 (56.72%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVK---VPKPASG-----AASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVE--YTLSYMTSAGTEKYMAPEVKNNTRA-NKNIDIYSLGVILEDLVGG 707
            E +G+G FG VY   N+ TG  +AVK   VPK +S      +  E  + E++ LK L HLNI+  L  E K+    L LEY   G +   IR   +F EP IK    Q+L GL Y+++K I+HRD+K  N+L+   G     KI+DFG+SR  +  Y+ S MT  GT  +MAPE+ +  +  +  +DI+SLG I+ ++  G
Sbjct: 1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDG---ICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAG 1376
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 114.39 bits (285), Expect = 1.139e-29
Identity = 80/253 (31.62%), Postives = 132/253 (52.17%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVKVPKPASGA---ASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG--------------NIKNAS--------PELQNLHKNMKEENYKKRF-----QLNDVKNHPF 812
            LG G FG V+  R+   G   A+K  K  +       E    E  +L  +SH  II +  + +   ++ +V++Y + G+L   +RK ++F  P  K +  ++   LEY+++K I++RDLKP+NIL +++ G I  KITDFG +++V   ++Y T  GT  Y+APEV +    NK++D +S GV++ +++ G              NI NA         P+ Q+L K +   +  +R         DVKNHP+
Sbjct:   94 LGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENIL-LDKNGHI--KITDFGFAKYVP-DVTY-TLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPW 341
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 115.161 bits (287), Expect = 3.716e-29
Identity = 84/256 (32.81%), Postives = 131/256 (51.17%), Query Frame = 3 
Query:  135 TECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLY-SEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYT-LSYMTSAGTEKYMAPEV-KNNTRANKNIDIYSLGVILEDLVGGN---------------IKNASPELQN--LHKNMKE-------ENYKKRFQLNDVKNHPFVK 818
            TE +G G FGVVYKG N++TG   A+KV    S +    D +REI  L +L  ++ IT  Y S  KD  + +++E+C  G L   +R  +   E  I   + ++L  L+ I+  +++HRD+K  N+LI N+G     K+ DFGV+  V  T L   T AGT  +MAPEV       +  +DI+SLG+   ++  GN               IK+  P L++     ++KE       E+ K+R   +D+    F++
Sbjct:   26 TEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGN---VKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIR 277
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 111.309 bits (277), Expect = 1.084e-28
Identity = 66/192 (34.38%), Postives = 112/192 (58.33%), Query Frame = 3 
Query:  141 CLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGA---ASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
             LG G FG V+  R++  G   A+KV K          E    E  +LK + H  +I +  + +    I +V++Y + G+L   +RK ++F  P  K +  +++  LEY++  +I++RDLKP+NIL +++ G I  KITDFG ++ V+ T+++ T  GT  Y+APEV      NK++D +SLGV++ +++ G
Sbjct:   75 TLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENIL-LDRNGHI--KITDFGFAKEVQ-TVTW-TLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAG 261
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 110.923 bits (276), Expect = 1.098e-27
Identity = 80/233 (34.33%), Postives = 120/233 (51.50%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFI-RKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMKEENY--KKRFQ--LNDVKNHPFVKN 821
            + +G G +GVVYK  N  T   VA+K     +         EI+LLK L+H NI+       K  ++ ++LEYC +G L   I R     SE E K ++ Q L GL+Y++ + ++HRD+K  NIL+       T K+ DFGVS  V    S +T AGT  +MAPE+  N  A+   DI+SLG  + +++  N    +    N++  ++ + Y     F   L D  +  FVKN
Sbjct:   29 QVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILL---SADNTVKLADFGVSTIVNS--SALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKN 256
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Match: EDO37799 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEV7])

HSP 1 Score: 117.472 bits (293), Expect = 2.162e-31
Identity = 82/272 (30.15%), Postives = 132/272 (48.53%), Query Frame = 3 
Query:  102 LTMRIGEYEYGT-ECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNI-----------------KNASP--------ELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            +T  +GE+ Y   + +G G F VV+KG++ +  +  VAVKV    + + +++   +EI +LK L H N+++L   +E    + LV+E      +   + KK   SE  I+ FL QI + +  + +K IVHRDLKP+N+L+ +          I  KI DFG +RF+   +   T  G+  YMAPEV  +   +   D++SLG I+   + G                   KN  P        +L++L   + + N K R    D   HPF+
Sbjct:    1 MTETVGEFFYNKKDLIGHGAFAVVFKGQHKKKSDFVVAVKVISKKNLSKTQSLLAKEIKILKELQHENVVSLFDCQELPSSVYLVMEVLYICQMLR-LTKKGTLSEDTIRMFLQQIASAMNALQSKGIVHRDLKPQNLLLSHSAASHPSPADIRIKIADFGFARFLPGEMMAATLCGSPMYMAPEVIMSKAYDARADLWSLGTIVYQCLTGKAPFQANSPQALKKFYEKNKNVCPNIPAGTSSQLKHLLMGLLKRNPKDRMDFGDFFTHPFL 271
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Match: EDO40703 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6E0])

HSP 1 Score: 117.857 bits (294), Expect = 3.049e-31
Identity = 70/202 (34.65%), Postives = 117/202 (57.92%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVKV--PKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ--ITYKITDFGVSRF---VEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
            YE+G + LG G FGVV + ++I TG   A+K    + A  +A +  +RE+ ++K + H ++I L    E   ++ LV+E C  G L + + +K++F+E E    + Q+++ + Y+++  IVHRDLK +NIL+ +  G   +  KITDFG+S     V       +  GT  YMAPEV ++   ++  D++S+GVI+  L  G
Sbjct:   27 YEFG-QVLGRGSFGVVNEAKHIETGTRWAIKAVNKEKAGSSAVKLLEREVMIMKKIYHEHLIHLEEIYETSKRMYLVMELCDAGGLDKMLERKKRFTEKETWTVIKQLVSAVAYLHDLDIVHRDLKLENILLSHPTGNELLNVKITDFGLSIVKGGVGSDSMMQSVCGTPMYMAPEVIDDLGYSQQCDVWSIGVIMYTLFTG 227
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Match: EDO36169 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJE6])

HSP 1 Score: 114.39 bits (285), Expect = 9.549e-29
Identity = 78/221 (35.29%), Postives = 113/221 (51.13%), Query Frame = 3 
Query:  108 MRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKV---PKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEV-KNNTRANKNIDIYSLGVILEDLVGGNIKNASPELQNLHKNMK 758
            + IG Y  G E LG G FG V    +  TG++VA+K+    K  S       +REI  LK   H +II L         I +V+EY   G+L E+I K  +  E + + F  QI++G++Y +   +VHRDLKP+N+L+     Q+  KI DFG+S  +       TS G+  Y APEV      A   +DI+S GVIL  L+ G +      +  L + +K
Sbjct:   15 LAIGNYNLG-ETLGVGTFGKVKLAVHQLTGHKVAIKILNRNKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMVMEYVSGGELFEYILKHGKLEEKDARRFFQQIISGVDYCHRHMVVHRDLKPENLLL---DSQLNIKIADFGLSNIMTDGEFLQTSCGSPNYAAPEVISGKLYAGPEVDIWSAGVILYALLCGTLPFDDEHIPTLFRKIK 231
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Match: EDO41399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I8])

HSP 1 Score: 110.153 bits (274), Expect = 3.508e-28
Identity = 67/196 (34.18%), Postives = 105/196 (53.57%), Query Frame = 3 
Query:  135 TECLGEGGFGVVYKGRNIRTGNE---VAVKV--PKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
             E LG+G +  VYK    + G+    VA+K    K  S AA+E    EI LL+ L H +I+ L   +  +  I L++EYC  GDL  FI  KR   E   + FL Q+   L+Y+ +  + H DLKP+N+L+ ++   +  KI DFG ++ +          G+  YMAPE+      + ++D++S+GVIL + + G
Sbjct:   20 AEKLGQGSYATVYKA--FKKGDNRDVVAIKCIKKKTLSKAATENLLTEIELLRNLEHEHIVQLKDFQWDENHIFLIMEYCGGGDLSRFIHSKRALPERMARKFLRQLACALQYMRSYDVAHMDLKPQNLLLSSRHNPVL-KIADFGFAQKLHPNSEASNIRGSPLYMAPEMICCQSYDASVDLWSVGVILYETLFG 212
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Match: EDO41242 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Z6])

HSP 1 Score: 108.612 bits (270), Expect = 4.111e-28
Identity = 62/193 (32.12%), Postives = 110/193 (56.99%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGK-IILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMT--SAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG 707
            E +GEG F  V++    +TG E A K  +       E  ++EIA+ K L H NI++L YS  ++G+ + L++EY   G L + + ++  +SE + +    Q+L  LEY++++ IVHRD+KP N+L+   G  +T K+ DFG+++ +      ++  ++G   ++APE        + +DI++ GVI   L+ G
Sbjct:    9 ELIGEGSFAKVFRCIERKTGLEFAAKELRLTDVEDKEKIEQEIAVWKDLRHENIVSL-YSSIREGETVCLIMEYVAGGSLFDEVIQQTYYSEKQARLVTRQLLNALEYLHSRRIVHRDIKPDNLLLKRTGNNVTIKLADFGLAQALPNDTDVISCGASGAPMFLAPETVLEEPIGRAVDIWACGVIFYLLLVG 200
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:NCBI gene;Acc:101155703])

HSP 1 Score: 142.51 bits (358), Expect = 1.023e-37
Identity = 89/269 (33.09%), Postives = 143/269 (53.16%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGN--IKNASPE--------LQNLHKNMKEE---------------NYKKRFQLNDVKNHPFVK 818
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S+T   +EI +LK L H NI+ LL  +E    + LV+EYC  GDL +++  K   SE  I+ FL QI+  ++ + +K I+HRDLKP+NIL+    G+      I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G    + +SP+         +NL  N+  E               N+K+R   ++   HPF++
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALLDFQETVSSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQIVGAIKVLQSKGIIHRDLKPQNILLSYPAGRKSHCNNICIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNYDARADLWSVGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSQHLRHLLLGLLQRNHKERMDFDEFFCHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Match: ulk1a (serine/threonine-protein kinase ULK1 [Source:NCBI gene;Acc:101167046])

HSP 1 Score: 139.428 bits (350), Expect = 1.107e-36
Identity = 88/269 (32.71%), Postives = 142/269 (52.79%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRNIRTGN-EVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQ------ITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNI-------------------------KNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            +G++E+   + +G G F VV+KGR+    + EVAVK     + A S++   +EI +LK L H NI+ LL  +E  G + LV+EYC  GDL E++  K   SE  I+ FL QI   ++ + +K I+HRDLKP+NIL+ +  G+       + KI DFG +R ++  +   T  G+  YMAPEV  +   +   D++S+G I+   + G                           K  SP L++L   + + N+K+R   ++  +HPF++
Sbjct:    4 VGKFEFSRKDLIGHGAFAVVFKGRHKEKHSWEVAVKCINKKNLAKSQSLLGKEIKILKELKHGNIVRLLDYQEIGGCVYLVMEYCNGGDLAEYLHSKGTLSEDTIRIFLQQIAQAMKVLQSKGILHRDLKPQNILLCHPEGRKSSSINASIKIADFGFARHLQTNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIMYQCLTGKAPFHASSPQELRLFYESNTTLLPSIPKETSPNLRHLLLGLLQRNHKERITFDEFFHHPFLE 272
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Match: ulk2 (serine/threonine-protein kinase ULK2 [Source:NCBI gene;Acc:101160680])

HSP 1 Score: 135.191 bits (339), Expect = 3.319e-35
Identity = 88/270 (32.59%), Postives = 140/270 (51.85%), Query Frame = 3 
Query:  114 IGEYEYG-TECLGEGGFGVVYKGRN-IRTGNEVAVKVPKPASGAASETD-KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQG------GQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-VILEDLVG-------------------GNI-----KNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVKN 821
            +G++EY   + +G G F VV+KGR+  +T  EVA+K     +   S+    +EI +LK L H NI+ L   +E    + LV+EYC  GDL ++++ K    E  ++ FL QI A +  +N+K I+HRDLKP+NIL+            I  KI DFG +R+++  +   T  G+  YMAPEV  +   +   D++S+G VI + LVG                    N+     +  SP+L +L   + + N K R   +   +HPF+++
Sbjct:    4 VGDFEYSRKDLVGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLTKSQILLGKEIKILKELQHENIVGLYDVQETPNSVFLVMEYCNGGDLADYLQAKGTLREDTMRVFLQQIAAAMRVLNSKGIIHRDLKPQNILLSYSARKRSNVSSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRLFYEKNKNLQPIIPRETSPQLTDLLLGLLQRNQKDRMDFDTFFSHPFLES 273
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Match: dapk2b (death associated protein kinase 2 [Source:NCBI gene;Acc:101165975])

HSP 1 Score: 125.561 bits (314), Expect = 3.433e-33
Identity = 81/265 (30.57%), Postives = 134/265 (50.57%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAAS------ETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQIT-YKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVG--------------GNIK------------NASPELQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            YE G E LG G F VV + +   +G E A K  K     AS      E  +RE+ +L+ L H NI+ L    E    ++L++E    G+L +F+ +K   SE E   F+ QIL G++Y+++K I H DLKP+NI+++++   +   K+ DFG++  +E    +    GT +++APE+ N  +     D++S+GVI   L+               GNI             N S   ++  + + E++ +KR  + D  NHP++K
Sbjct:   18 YEMG-EQLGSGQFAVVKRCKEKSSGTEFAAKFIKKRISRASRRGVKREEIEREVGILQQLQHPNIVALHDVYENRTDVVLIMELVSGGELFDFLAQKESLSEEEATQFIKQILDGVQYLHSKRIAHFDLKPENIMLLDRNASLPRIKLIDFGLAHQIEAGADFKNIFGTPEFVAPEIVNYEQLGLEADMWSIGVITYILLSGASPFLGDTKQETLGNISAVNYEFDEDFFGNTSELAKSFIRQLLEKDTRKRMAIEDALNHPWIK 281
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Match: dapk1 (death associated protein kinase 1 [Source:NCBI gene;Acc:101162667])

HSP 1 Score: 124.405 bits (311), Expect = 1.955e-31
Identity = 78/211 (36.97%), Postives = 116/211 (54.98%), Query Frame = 3 
Query:  123 YEYGTECLGEGGFGVVYKGRNIRTGNEVAVKV------PKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGG-QITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKNASPEL 734
            YE G E LG G F VV + R+  +G + A K            G + E  +RE+ +LK + H NIITL    E   ++IL+LE    G+L +F+ +K   SE E   FL QIL G+ Y+++K I H DLKP+NI+++N+       KI DFG++  +++   +    GT +++APEV N        D++S+GVI   L+ G    ASP L
Sbjct:   13 YEIGEE-LGSGQFAVVRRCRHRSSGADYAAKFIKKRRSKSSRRGVSREDIEREVNILKEIQHPNIITLQEVFENKAEVILILELVAGGELFDFLAEKESLSEEEATQFLKQILDGVLYLHSKQIAHFDLKPENIMLLNRSAPHPRIKIIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYEPLGLEADMWSVGVITYILLSG----ASPFL 218
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Match: SMESG000012127.1 (SMESG000012127.1)

HSP 1 Score: 148.288 bits (373), Expect = 5.385e-43
Identity = 88/230 (38.26%), Postives = 138/230 (60.00%), Query Frame = 3 
Query:  144 LGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRK-KRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKN-----ASPELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            LG+GGFG+VY+G N++    VAVKV    +   S+  + EI  LK L+  NI+ LL      G +IL++E C +GD+   I+   RQFSEPEI+ F+ Q   GL YI+N  I+HRD+KP NIL  ++  ++ YKI+DFG+S+ ++ T   M+   ++ Y APE+ +   AN N D++SLG  +  ++  +I +      S +L +L   M EE+   R + ++V +H F+
Sbjct:   15 LGQGGFGMVYRGENVQDRTNVAVKVI--YNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELC-EGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGT-EKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 240
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Match: SMESG000012131.1 (SMESG000012131.1)

HSP 1 Score: 147.902 bits (372), Expect = 1.089e-42
Identity = 98/262 (37.40%), Postives = 142/262 (54.20%), Query Frame = 3 
Query:  114 IGEYEYGTE-CLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRK-KRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLG-----VILEDL--------------VGGNIKNASP-------ELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            IG Y +     LG+GGFG VY+G+N++ G  VAVKV        S+  + EI  LK L+  NI+ LL      G +IL+++ C +GD+   I+   RQFSEPEI+ FL Q   GL YI+N  I+HRD+KP NIL  ++  Q+ YKI+DFG+S+ +E T   M+   ++ Y APE+ N   AN N D++SLG     +   D+              + G I   S         L +L   M E+++ +RF   DV +H F+
Sbjct:    4 IGNYYFDQRNFLGQGGFGTVYRGKNVQDGTNVAVKVIYNYR--LSQYQRTEIDNLKGLNCRNIVRLLDYFIITGNVILIMKLC-EGDMESRIQNIGRQFSEPEIRDFLQQTATGLRYIHNNGILHRDIKPANILFTHESWQLVYKISDFGISKMIEGT-ERMSIRASDIYSAPEINNYGVANFNSDVWSLGRTVCYMFFRDINKMNNYLVSLDSQKIFGRIFGHSACNYGIYLGLHDLLGRMLEKDHNRRFGAGDVLSHYFI 261
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Match: SMESG000012127.1 (SMESG000012127.1)

HSP 1 Score: 134.42 bits (337), Expect = 5.119e-38
Identity = 82/223 (36.77%), Postives = 131/223 (58.74%), Query Frame = 3 
Query:  165 VVYKGRNIRTGNEVAVKVPKPASGAASETDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRK-KRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGGNIKN-----ASPELQNLHKNMKEENYKKRFQLNDVKNHPFV 815
            +VY+G N++    VAVKV    +   S+  + EI  LK L+  NI+ LL      G +IL++E C+ GD+   I+   RQFSEPEI+ F+ Q   GL YI+N  I+HRD+KP NIL  ++  ++ YKI+DFG+S+ ++ T   M+   ++ Y APE+ +   AN N D++SLG  +  ++  +I +      S +L +L   M EE+   R + ++V +H F+
Sbjct:    1 MVYRGENVQDRTNVAVKVI--YNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGT-EKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 219
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Match: SMESG000076885.1 (SMESG000076885.1)

HSP 1 Score: 123.635 bits (309), Expect = 2.977e-31
Identity = 85/256 (33.20%), Postives = 135/256 (52.73%), Query Frame = 3 
Query:  138 ECLGEGGFGVVYKGRNIRTGNEVAVK-VPKPASGAASETD----KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKITDFGVSRFVEYTLSYMTSA-GTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG-------NI---------------KNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVKN 821
            E +GEG FG VY+GR   TG  VA+K +PK   G  SE D    KREI ++K+L+H NII +L + E   +++ V +Y  DG+L + +       E  +      +++ L Y+++  I+HRD+KP+NIL+   G     K+ DFG +R +      +TS  GT  YM+PE+      +   D+++LG IL +L  G       NI               K  S + ++  + + +++ KKR Q  DV +HPFV++
Sbjct:    8 EHIGEGSFGKVYRGRKKHTGEIVAMKFIPK---GGKSEKDLANLKREIEIMKSLNHPNIIQMLDAFETPKEVVAVTDY-ADGELFQVLEDDGNLPESVVSIIAGHLVSALFYLHSHRILHRDMKPQNILLSQNG----VKLCDFGFAREMSIDTLVLTSIKGTPLYMSPELIQEKPYDHTADLWALGCILYELFVGRPPFYTNNIFELMNIIIKGTIKWPKEMSEDFRSFIQGLLQKDPKKRLQWPDVLHHPFVES 255
[Close]
BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Match: SMESG000057975.1 (SMESG000057975.1)

HSP 1 Score: 122.094 bits (305), Expect = 9.380e-31
Identity = 82/282 (29.08%), Postives = 138/282 (48.94%), Query Frame = 3 
Query:   99 MLTMRIGEYEYG-TECLGEGGFGVVYKGR-NIRTGNEVAVKVPKPASGAASETD---KREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKRQFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQG-------------GQITYKITDFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDLVGG--NIKNASPE----------------------LQNLHKNMKEENYKKRFQLNDVKNHPFVK 818
            M  + +G++EY     LG G F +VY+GR   +   +VA+K  + +     ++     +EIA+LK L+H NI+ L         + L +EYC  GDL + + ++R  SE  I + L Q+ + L+ +N + I+HRDLKP NIL+                  ++ YK+ DFG +RF++  +  +T  G+  YMAPEV        ++DI+S+GVI+   + G    + ++PE                      L+++   M  +N   R    ++  HPFV+
Sbjct:    1 MSLINVGKFEYNPANVLGNGAFAIVYEGRFKEKPDQKVAIKAMRGSDRNLVKSKNLLSKEIAVLKDLNHPNIVRLFDHMIAPDGVYLFMEYCNGGDLAKVLSERRTLSEENICSILSQLSSALDVMNLQGIMHRDLKPGNILLCYPPDIKVKKPSFDLIKSKVKYKLADFGFARFLQDGIMAVTMCGSPMYMAPEVLLCKNYTISVDIWSMGVIIYQCLTGVAPFQASNPEALKAIYQKQLDPIRFPPQTSKYLRDVIVKMLVKNPSNRISFKNIMQHPFVR 282
The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ULK11.327e-3632.47unc-51 like autophagy activating kinase 1 [Source:... [more]
ULK21.132e-3437.68unc-51 like autophagy activating kinase 2 [Source:... [more]
ULK21.132e-3437.68unc-51 like autophagy activating kinase 2 [Source:... [more]
STK361.005e-3130.28serine/threonine kinase 36 [Source:HGNC Symbol;Acc... [more]
DAPK27.115e-3136.02death associated protein kinase 2 [Source:HGNC Sym... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
unc-511.367e-3533.58Serine/threonine-protein kinase unc-51 [Source:Un... [more]
par-14.852e-2830.51Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-15.382e-2830.51Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-15.382e-2830.51Serine/threonine-protein kinase par-1 [Source:Uni... [more]
par-15.382e-2830.51Serine/threonine-protein kinase par-1 [Source:Uni... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Atg11.470e-3437.62gene:FBgn0260945 transcript:FBtr0075945[more]
Atg11.687e-3437.62gene:FBgn0260945 transcript:FBtr0300561[more]
CG72361.865e-3036.65gene:FBgn0031730 transcript:FBtr0302950[more]
CG72361.979e-3036.65gene:FBgn0031730 transcript:FBtr0343389[more]
CG72362.008e-3036.65gene:FBgn0031730 transcript:FBtr0343388[more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ulk1a2.783e-3832.46unc-51 like autophagy activating kinase 1a [Source... [more]
ulk21.641e-3633.46unc-51 like autophagy activating kinase 2 [Source:... [more]
ulk1a2.810e-3632.34unc-51 like autophagy activating kinase 1a [Source... [more]
ulk1b1.480e-3531.97unc-51 like autophagy activating kinase 1 [Source:... [more]
sik2b1.463e-3235.11salt-inducible kinase 2b [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
twnk9.198e-3833.21twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE... [more]
ULK22.221e-3433.58unc-51 like autophagy activating kinase 2 [Source:... [more]
twnk2.307e-3231.34twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE... [more]
twnk1.843e-3135.02twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE... [more]
twnk1.874e-3135.02twinkle mtDNA helicase [Source:Xenbase;Acc:XB-GENE... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ulk13.856e-3732.46unc-51 like kinase 1 [Source:MGI Symbol;Acc:MGI:12... [more]
Ulk13.862e-3732.46unc-51 like kinase 1 [Source:MGI Symbol;Acc:MGI:12... [more]
Ulk22.465e-3438.46unc-51 like kinase 2 [Source:MGI Symbol;Acc:MGI:13... [more]
Dapk31.032e-3234.80death-associated protein kinase 3 [Source:MGI Symb... [more]
Dapk39.769e-3235.05death-associated protein kinase 3 [Source:MGI Symb... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O70405|ULK1_MOUSE2.697e-3632.46Serine/threonine-protein kinase ULK1 OS=Mus muscul... [more]
sp|O75385|ULK1_HUMAN6.372e-3632.47Serine/threonine-protein kinase ULK1 OS=Homo sapie... [more]
sp|Q23023|UNC51_CAEEL1.739e-3433.58Serine/threonine-protein kinase unc-51 OS=Caenorha... [more]
sp|F4JBP3|ATG1B_ARATH2.488e-3431.82Serine/threonine-protein kinase ATG1b OS=Arabidops... [more]
sp|Q8IYT8|ULK2_HUMAN5.434e-3437.68Serine/threonine-protein kinase ULK2 OS=Homo sapie... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1D2N4Y13.514e-3734.94Serine/threonine-protein kinase ULK2 OS=Orchesella... [more]
A0A087TZ914.878e-3734.07Serine/threonine-protein kinase ULK2 (Fragment) OS... [more]
K7IRV47.328e-3734.43Protein kinase domain-containing protein OS=Nasoni... [more]
A0A3Q0JT092.030e-3638.63serine/threonine-protein kinase ULK1-like OS=Ciona... [more]
A0A0L7R8F96.502e-3633.70Serine/threonine-protein kinase ULK2 OS=Habropoda ... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ulk1b2.903e-3733.09unc-51 like autophagy activating kinase 1 [Source:... [more]
ulk1b2.919e-3733.09unc-51 like autophagy activating kinase 1 [Source:... [more]
ulk24.684e-3633.46unc-51 like autophagy activating kinase 2 [Source:... [more]
ulk1a4.514e-3331.60unc-51 like autophagy activating kinase 1a [Source... [more]
sik2b1.579e-3133.05salt-inducible kinase 2b [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STK363.702e-3131.87serine/threonine kinase 36 [Source:HGNC Symbol;Acc... [more]
ENSPMAT00000001278.13.112e-2934.80pep scaffold:Pmarinus_7.0:GL476529:253165:339525:-... [more]
cdk21.219e-2837.44cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
MARK31.239e-2832.64microtubule affinity regulating kinase 3 [Source:H... [more]
snrka5.937e-2830.68SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
BCK11.402e-3039.30MAPKKK acting in the protein kinase C signaling pa... [more]
TPK31.139e-2931.62cAMP-dependent protein kinase catalytic subunit; p... [more]
KIC13.716e-2932.81Protein kinase of the PAK/Ste20 family, required f... [more]
TPK21.084e-2834.38cAMP-dependent protein kinase catalytic subunit; p... [more]
CDC151.098e-2734.33Protein kinase of the Mitotic Exit Network; locali... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO377992.162e-3130.15Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO407033.049e-3134.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361699.549e-2935.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413993.508e-2834.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO412424.111e-2832.12Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ulk1b1.023e-3733.09unc-51 like autophagy activating kinase 1 [Source:... [more]
ulk1a1.107e-3632.71serine/threonine-protein kinase ULK1 [Source:NCBI ... [more]
ulk23.319e-3532.59serine/threonine-protein kinase ULK2 [Source:NCBI ... [more]
dapk2b3.433e-3330.57death associated protein kinase 2 [Source:NCBI gen... [more]
dapk11.955e-3136.97death associated protein kinase 1 [Source:NCBI gen... [more]
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BLAST of Serine/threonine-protein kinase ULK2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000012127.15.385e-4338.26SMESG000012127.1[more]
SMESG000012131.11.089e-4237.40SMESG000012131.1[more]
SMESG000012127.15.119e-3836.77SMESG000012127.1[more]
SMESG000076885.12.977e-3133.20SMESG000076885.1[more]
SMESG000057975.19.380e-3129.08SMESG000057975.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001480 ID=SMED30001480|Name=Serine/threonine-protein kinase ULK2|organism=Schmidtea mediterranea sexual|type=transcript|length=886bp
AGTAAACAAAAACAAATTGTGAACTCTGATTGGTTAGTGAAATTATTCCA
AGAATTCACAGACAATATATAAACTCATAGAATTAAAACAAAAATTCAAT
GCTTACAATGAGAATAGGTGAATATGAATATGGTACCGAATGCCTTGGAG
AGGGCGGTTTTGGAGTAGTTTACAAAGGAAGGAATATCAGAACAGGCAAT
GAAGTAGCCGTGAAAGTACCAAAGCCTGCAAGTGGGGCAGCATCAGAAAC
GGATAAAAGAGAAATTGCACTTTTAAAAACATTGAGCCATTTGAACATAA
TAACTCTTCTTTACTCGGAAGAGAAAGATGGCAAAATCATTTTGGTCCTG
GAATACTGCAAAGACGGAGACCTACATGAATTTATTAGAAAAAAACGCCA
ATTCAGTGAACCGGAAATCAAGGCATTTCTACATCAAATATTGGCGGGCC
TTGAATACATCAACAACAAAAGTATTGTCCACAGGGACCTGAAACCTAAA
AACATTTTGATAATCAATCAGGGGGGTCAGATCACCTATAAAATTACTGA
TTTTGGAGTTTCTCGATTTGTTGAGTACACTTTGTCGTACATGACCTCGG
CCGGAACTGAAAAATATATGGCTCCAGAGGTGAAAAACAATACACGGGCA
AATAAAAATATTGACATCTACAGCCTTGGAGTTATTCTCGAGGATTTGGT
CGGCGGCAACATTAAAAATGCGAGTCCGGAGTTGCAAAACTTGCATAAAA
ATATGAAGGAAGAAAATTATAAGAAAAGATTTCAATTGAATGATGTCAAA
AATCATCCATTCGTGAAAAATTAATTCTTGGCGCAAATGTGATGATAGGC
TGACAAATTGAAATTGTTATATGGAAACATTATTAT
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protein sequence of SMED30001480-orf-1

>SMED30001480-orf-1 ID=SMED30001480-orf-1|Name=SMED30001480-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=242bp
MLTMRIGEYEYGTECLGEGGFGVVYKGRNIRTGNEVAVKVPKPASGAASE
TDKREIALLKTLSHLNIITLLYSEEKDGKIILVLEYCKDGDLHEFIRKKR
QFSEPEIKAFLHQILAGLEYINNKSIVHRDLKPKNILIINQGGQITYKIT
DFGVSRFVEYTLSYMTSAGTEKYMAPEVKNNTRANKNIDIYSLGVILEDL
VGGNIKNASPELQNLHKNMKEENYKKRFQLNDVKNHPFVKN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0003116parenchymal cell
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 9..239
e-value: 8.7E-57
score: 204.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 14..203
e-value: 2.2E-55
score: 187.9
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 10..241
score: 39.849
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 12..237
e-value: 9.5E-28
score: 94.7
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 3..241
e-value: 1.8E-68
score: 233.2
NoneNo IPR availablePANTHERPTHR24347:SF412CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE Icoord: 11..240
NoneNo IPR availablePANTHERPTHR24347SERINE/THREONINE-PROTEIN KINASEcoord: 11..240
NoneNo IPR availableCDDcd00180PKccoord: 16..237
e-value: 2.00466E-62
score: 192.485
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 16..39
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 126..138
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 5..240