Dual specificity tyrosine-phosphorylation-regulated kinase 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001404 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 491.5 bits (1264), Expect = 3.136e-167 Identity = 259/423 (61.23%), Postives = 319/423 (75.41%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
+ P+ P AMK +M K+T FE HEIF YP++Y+LG NA+K + +T NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR F +S PRYC V + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K T
Sbjct: 78 ATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT--LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR-LPKPPTGEKTSVKRITEST 484
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 493.426 bits (1269), Expect = 6.297e-167 Identity = 258/417 (61.87%), Postives = 318/417 (76.26%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQK 1368
+ P+ P AMK +M K+T FE HEIF YP++Y+LG NA+K + +T NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR F +S PRYC V + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K
Sbjct: 151 ATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT--LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR-LPKPPTGEKTSVK 551
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 443.351 bits (1139), Expect = 8.312e-148 Identity = 239/409 (58.44%), Postives = 298/409 (72.86%), Query Frame = 1
Query: 97 TSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
+S + P PL P A+K + + +T +E+ EI YP++Y++G NA+K + NN G+DD G+YIHV DH+AYRYEV+K+IGKGSFGQV + YDHKL YVALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +L+ELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGEDE DQL+CM+ELLG+PP LL KR F S IPRYC V + L G ++RGK RGPPGSK LK +D LF++F++R L ++P R+ P +A++H WI +
Sbjct: 111 SSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNN------------GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALKGC-DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 504
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 443.351 bits (1139), Expect = 8.312e-148 Identity = 239/409 (58.44%), Postives = 298/409 (72.86%), Query Frame = 1
Query: 97 TSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
+S + P PL P A+K + + +T +E+ EI YP++Y++G NA+K + NN G+DD G+YIHV DH+AYRYEV+K+IGKGSFGQV + YDHKL YVALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +L+ELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGEDE DQL+CM+ELLG+PP LL KR F S IPRYC V + L G ++RGK RGPPGSK LK +D LF++F++R L ++P R+ P +A++H WI +
Sbjct: 111 SSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNN------------GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALKGC-DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 504
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 443.736 bits (1140), Expect = 1.108e-147 Identity = 241/413 (58.35%), Postives = 300/413 (72.64%), Query Frame = 1
Query: 97 TSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIP 1335
+S + P PL P A+K + + +T +E+ EI YP++Y++G NA+K + NN G+DD G+YIHV DH+AYRYEV+K+IGKGSFGQV + YDHKL YVALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +L+ELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGEDE DQL+CM+ELLG+PP LL KR F S IPRYC V + L G ++RGK RGPPGSK LK +D LF++F++R L ++P R+ P +A++H WI K +P
Sbjct: 131 SSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNN------------GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALKGC-DDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-SKSVP 527
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 448.358 bits (1152), Expect = 1.329e-151 Identity = 238/398 (59.80%), Postives = 300/398 (75.38%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 450
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 448.358 bits (1152), Expect = 1.329e-151 Identity = 238/398 (59.80%), Postives = 300/398 (75.38%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 450
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 448.358 bits (1152), Expect = 1.329e-151 Identity = 238/398 (59.80%), Postives = 300/398 (75.38%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 450
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 448.358 bits (1152), Expect = 1.557e-151 Identity = 241/419 (57.52%), Postives = 308/419 (73.51%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTC 1389
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+ + G +S +++ C
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADHEVC 471
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 448.358 bits (1152), Expect = 1.557e-151 Identity = 241/419 (57.52%), Postives = 308/419 (73.51%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTC 1389
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+ + G +S +++ C
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRDGLESMGGLADHEVC 471
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100406) HSP 1 Score: 437.958 bits (1125), Expect = 8.818e-143 Identity = 238/400 (59.50%), Postives = 304/400 (76.00%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
++P+ M +MNK+T +E+ EI YPQ+Y++G NA+K + N+ +D+EQG+YIHV DH+AYRYE++K+IGKGSFGQV+KAYDHK +VALKIVRNEKRF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NL+ELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++G+ LFPGE+ESDQL+C+IE+LG+P N+L + KR+ FF+ PRYC V + M L G ++RGK RGPP SKS+ L DPLF++FIR L+++ + R+ P EA+KH W+RR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSE-------------YDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRT--MSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100404) HSP 1 Score: 437.958 bits (1125), Expect = 8.818e-143 Identity = 238/400 (59.50%), Postives = 304/400 (76.00%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
++P+ M +MNK+T +E+ EI YPQ+Y++G NA+K + N+ +D+EQG+YIHV DH+AYRYE++K+IGKGSFGQV+KAYDHK +VALKIVRNEKRF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NL+ELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++G+ LFPGE+ESDQL+C+IE+LG+P N+L + KR+ FF+ PRYC V + M L G ++RGK RGPP SKS+ L DPLF++FIR L+++ + R+ P EA+KH W+RR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSE-------------YDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRT--MSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100402) HSP 1 Score: 437.958 bits (1125), Expect = 8.818e-143 Identity = 238/400 (59.50%), Postives = 304/400 (76.00%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
++P+ M +MNK+T +E+ EI YPQ+Y++G NA+K + N+ +D+EQG+YIHV DH+AYRYE++K+IGKGSFGQV+KAYDHK +VALKIVRNEKRF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NL+ELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++G+ LFPGE+ESDQL+C+IE+LG+P N+L + KR+ FF+ PRYC V + M L G ++RGK RGPP SKS+ L DPLF++FIR L+++ + R+ P EA+KH W+RR+
Sbjct: 209 VSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSE-------------YDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRT--MSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRR 592
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100447) HSP 1 Score: 339.732 bits (870), Expect = 2.670e-106 Identity = 192/399 (48.12%), Postives = 265/399 (66.42%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIR 1320
P+ P +K F N +T E E+ Y +V+Y GQ+A K NY + N G+DD+ G+Y + DHIA+RYE++++IGKGSFGQV++A DHK +VA+KI+RN+KRF QA E+ IL+ L++ D + N++H+ ++ FR H+CITFEL++ NL+ELIKKN + GFS+ L+R+F SI++CL L K IIHCDLKPENILL+ SSIKVIDFGSSCY ++++YTYIQSRFYR+PEVILG +YG IDMWS GCILAEL TG+PLFPGE+E +QL+C++E+LGLPP L+ +R FF S PR +G+ R PGSKS+ + L D F+DF++R L+++P RM P EA H++++
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASK---------NYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCIT-----------------NTKGRKRS-PGSKSLAHILHC--QDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089289) HSP 1 Score: 339.732 bits (870), Expect = 2.670e-106 Identity = 192/399 (48.12%), Postives = 265/399 (66.42%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIR 1320
P+ P +K F N +T E E+ Y +V+Y GQ+A K NY + N G+DD+ G+Y + DHIA+RYE++++IGKGSFGQV++A DHK +VA+KI+RN+KRF QA E+ IL+ L++ D + N++H+ ++ FR H+CITFEL++ NL+ELIKKN + GFS+ L+R+F SI++CL L K IIHCDLKPENILL+ SSIKVIDFGSSCY ++++YTYIQSRFYR+PEVILG +YG IDMWS GCILAEL TG+PLFPGE+E +QL+C++E+LGLPP L+ +R FF S PR +G+ R PGSKS+ + L D F+DF++R L+++P RM P EA H++++
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASK---------NYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCIT-----------------NTKGRKRS-PGSKSLAHILHC--QDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 475.322 bits (1222), Expect = 2.511e-160 Identity = 260/438 (59.36%), Postives = 327/438 (74.66%), Query Frame = 1
Query: 73 GNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
G+S ++T + P PL P AMK +M+K+++FE EI Y ++Y++G NA+K + + NN G+DD+QGSYIHV DHIAYRYEV+K+IGKGSFGQVVKAYDHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+C+IE+LG+P LL + KR F +S PRYC V P + L G ++RGK RGPPGS+ LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P K EK+ K GT
Sbjct: 114 GSSTSIKSTESK-PKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNN------------GGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALKGC-DDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LP-KPPTEKTTVKRITEGT 533
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 474.937 bits (1221), Expect = 4.308e-160 Identity = 260/438 (59.36%), Postives = 327/438 (74.66%), Query Frame = 1
Query: 73 GNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
G+S ++T + P PL P AMK +M+K+++FE EI Y ++Y++G NA+K + + NN G+DD+QGSYIHV DHIAYRYEV+K+IGKGSFGQVVKAYDHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+C+IE+LG+P LL + KR F +S PRYC V P + L G ++RGK RGPPGS+ LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P K EK+ K GT
Sbjct: 124 GSSTSIKSTESK-PKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNN------------GGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALKGC-DDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LP-KPPTEKTTVKRITEGT 543
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 474.167 bits (1219), Expect = 1.395e-159 Identity = 260/438 (59.36%), Postives = 327/438 (74.66%), Query Frame = 1
Query: 73 GNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
G+S ++T + P PL P AMK +M+K+++FE EI Y ++Y++G NA+K + + NN G+DD+QGSYIHV DHIAYRYEV+K+IGKGSFGQVVKAYDHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+C+IE+LG+P LL + KR F +S PRYC V P + L G ++RGK RGPPGS+ LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P K EK+ K GT
Sbjct: 135 GSSTSIKSTESK-PKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNN------------GGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALKGC-DDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRR-LP-KPPTEKTTVKRITEGT 554
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 462.996 bits (1190), Expect = 1.909e-155 Identity = 255/450 (56.67%), Postives = 320/450 (71.11%), Query Frame = 1
Query: 115 LSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSF--QKESENGTC-QDILATAIDVEFSNKNDSSGTM 1455
L P+ P A+K ++T EQ EI Y ++Y+LG NA+K + + NN +G+DD+QG YIHV DH+AYRYE +K+IGKGSFGQV K YDHKL +VALKIVRNEKRF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TGYPLFPGEDE DQL+CM+ELLG+PP LL KR F +S PRYC V+ + L GS ++RGK RG PGSK LK D F+DF+++ LD++P TRM P +A++H W+ ++ GEK+ ++ SE+ T I++ V S N TM
Sbjct: 128 LGSPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNN------------SGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVST--LSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGC-EDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLPKPAPGGEKTVLPKRISEHSTSFPTIISKVPPVMGSTNNKLRTTM 562
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 462.611 bits (1189), Expect = 2.244e-155 Identity = 255/450 (56.67%), Postives = 320/450 (71.11%), Query Frame = 1
Query: 115 LSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSF--QKESENGTC-QDILATAIDVEFSNKNDSSGTM 1455
L P+ P A+K ++T EQ EI Y ++Y+LG NA+K + + NN +G+DD+QG YIHV DH+AYRYE +K+IGKGSFGQV K YDHKL +VALKIVRNEKRF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TGYPLFPGEDE DQL+CM+ELLG+PP LL KR F +S PRYC V+ + L GS ++RGK RG PGSK LK D F+DF+++ LD++P TRM P +A++H W+ ++ GEK+ ++ SE+ T I++ V S N TM
Sbjct: 129 LGSPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNN------------SGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVST--LSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGC-EDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLPKPAPGGEKTVLPKRISEHSTSFPTIISKVPPVMGSTNNKLRTTM 563
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:100485120]) HSP 1 Score: 497.664 bits (1280), Expect = 3.306e-168 Identity = 261/413 (63.20%), Postives = 316/413 (76.51%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEK 1356
S L P AMK +M K+T FE HEIF YP++Y+LG NA+K + + NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHKL +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILGG+YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR FF+S PRYC V P + L G ++RGK RGPPGS+ LK +DPLF+DF+ + L+++P RM P +A++H W+RR+ +P GEK
Sbjct: 175 SSSLTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVIGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVV--LNGGRSRRGKLRGPPGSRDWVTALKGC-DDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRR-LPKPPTGEK 571
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 439.499 bits (1129), Expect = 1.217e-146 Identity = 246/452 (54.42%), Postives = 317/452 (70.13%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTCQ---------DILATAIDVEFSNKNDSSGTM 1455
L P A+K + ++++ +E EI + ++Y++G NA+K + + NN G+DD+QG Y V DH+AYRYEV+K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TGYPLFPGEDE DQL+CM+ELLG PP LL KR F S PRYC V P ++ L GS ++RGK RG PGSK LK D LF+DF++ L ++P RM P +A++HQWI ++ +P + EK+ K + T ++ A + + NDS+G++
Sbjct: 100 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNN------------GGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALKGC-EDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKR-LPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSI 535
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 439.113 bits (1128), Expect = 1.545e-146 Identity = 246/452 (54.42%), Postives = 317/452 (70.13%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTCQ---------DILATAIDVEFSNKNDSSGTM 1455
L P A+K + ++++ +E EI + ++Y++G NA+K + + NN G+DD+QG Y V DH+AYRYEV+K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TGYPLFPGEDE DQL+CM+ELLG PP LL KR F S PRYC V P ++ L GS ++RGK RG PGSK LK D LF+DF++ L ++P RM P +A++HQWI ++ +P + EK+ K + T ++ A + + NDS+G++
Sbjct: 93 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNN------------GGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALKGC-EDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKR-LPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSI 528
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 438.343 bits (1126), Expect = 1.667e-146 Identity = 246/452 (54.42%), Postives = 317/452 (70.13%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTCQ---------DILATAIDVEFSNKNDSSGTM 1455
L P A+K + ++++ +E EI + ++Y++G NA+K + + NN G+DD+QG Y V DH+AYRYEV+K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TGYPLFPGEDE DQL+CM+ELLG PP LL KR F S PRYC V P ++ L GS ++RGK RG PGSK LK D LF+DF++ L ++P RM P +A++HQWI ++ +P + EK+ K + T ++ A + + NDS+G++
Sbjct: 83 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNN------------GGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALKGC-EDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKR-LPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSI 518
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 439.884 bits (1130), Expect = 1.720e-146 Identity = 246/452 (54.42%), Postives = 317/452 (70.13%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGTCQ---------DILATAIDVEFSNKNDSSGTM 1455
L P A+K + ++++ +E EI + ++Y++G NA+K + + NN G+DD+QG Y V DH+AYRYEV+K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TGYPLFPGEDE DQL+CM+ELLG PP LL KR F S PRYC V P ++ L GS ++RGK RG PGSK LK D LF+DF++ L ++P RM P +A++HQWI ++ +P + EK+ K + T ++ A + + NDS+G++
Sbjct: 122 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNN------------GGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALKGC-EDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKR-LPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSI 557
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:MGI Symbol;Acc:MGI:1330301]) HSP 1 Score: 496.893 bits (1278), Expect = 1.795e-168 Identity = 260/423 (61.47%), Postives = 320/423 (75.65%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
+ P+ P AMK +M K+T FE HEIF YP++Y+LG NA+K + +T NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RSSIKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR F +S PRYC V + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K T
Sbjct: 149 ASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT--LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR-LPKPPTGEKTAVKRVTEST 555
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]) HSP 1 Score: 445.277 bits (1144), Expect = 1.596e-148 Identity = 237/400 (59.25%), Postives = 295/400 (73.75%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
PL P A+K + + +T +E+ EI YP++Y++G NA+K + + NN G+DD G+YIHV DH+AYRYEV+K+IGKGSFGQV + YDHKL YVALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +L+ELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RS+ KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGEDE DQL+CMIELLG+PP LL KR F S +PRYC V+ L G ++RGK RGPPGSK LK G D LF++F++R L ++P R+ P +A++H WI +
Sbjct: 139 PLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNN------------GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQ--TDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCG-DYLFIEFLKRCLQWDPSARLTPAQALRHPWISK 523
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:MGI Symbol;Acc:MGI:1330292]) HSP 1 Score: 355.525 bits (911), Expect = 3.276e-113 Identity = 204/398 (51.26%), Postives = 267/398 (67.09%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWI 1317
PL A+K+F N+++ +EQ EI Y ++++LG A+K N PE S FDDE GSY+ VL DHIAYRYEV+++IGKGSFGQV K DHK VALKI+RN+KRF QA E++ILE L++ DK++ N+VH+ + F FRNH+CITFELL NL+EL+K N F GF+L +VR+F SIL+CL L +IIHCDLKPENI+L + ++KVIDFGSSCYE+Q+VYTYIQSRFYR+PEVILG Y + IDMWS GCI+AEL TGYPLFPGE+E +QL+C++E+LGLPP + R FF S +P+ ++N +G +Y P SK + +KT D F+DF+RR L + P RM P +A+KH WI
Sbjct: 150 PLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKL-------NVVPEKFSK-----TSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPK-----------NINNNRGG----KRY---PDSKDLTMVVKTY--DSSFLDFLRRCLVWEPSLRMTPEQALKHAWI 515
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 268.47 bits (685), Expect = 3.480e-80 Identity = 170/385 (44.16%), Postives = 230/385 (59.74%), Query Frame = 1
Query: 205 QVYYLGQNAQKSRRLTQQKNNYPESCSNLEE---FNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFF-----TSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKC 1329
+VYY A+K RR Q P+ S +E N+G+DD+ YI + RYE+ LIGKGSFGQVVKAYDH+ VA+KI++N+K F QA E+R+LE + Q+D E K IVH+ HF FRNH+C+ FELL+ NL++L++ FRG SL L RK A + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G +E DQ+S ++E+LG+PP +L + K+F + R E+ +D P +L+ G G PG + + + F D + R L++ P R+ P A++H + RR
Sbjct: 61 EVYY----AKKKRRAQQAP---PQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVL---GVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTA 435
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 267.7 bits (683), Expect = 2.569e-79 Identity = 170/385 (44.16%), Postives = 230/385 (59.74%), Query Frame = 1
Query: 205 QVYYLGQNAQKSRRLTQQKNNYPESCSNLEE---FNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFF-----TSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKC 1329
+VYY A+K RR Q P+ S +E N+G+DD+ YI + RYE+ LIGKGSFGQVVKAYDH+ VA+KI++N+K F QA E+R+LE + Q+D E K IVH+ HF FRNH+C+ FELL+ NL++L++ FRG SL L RK A + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G +E DQ+S ++E+LG+PP +L + K+F + R E+ +D P +L+ G G PG + + + F D + R L++ P R+ P A++H + RR
Sbjct: 121 EVYY----AKKKRRAQQAP---PQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVL---GVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTA 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5U4C9|DYRK2_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Mus musculus OX=10090 GN=Dyrk2 PE=2 SV=1) HSP 1 Score: 496.893 bits (1278), Expect = 1.256e-167 Identity = 260/423 (61.47%), Postives = 320/423 (75.65%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
+ P+ P AMK +M K+T FE HEIF YP++Y+LG NA+K + +T NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RSSIKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR F +S PRYC V + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K T
Sbjct: 149 ASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT--LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR-LPKPPTGEKTAVKRVTEST 555
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q92630|DYRK2_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3) HSP 1 Score: 493.426 bits (1269), Expect = 3.024e-166 Identity = 258/417 (61.87%), Postives = 318/417 (76.26%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQK 1368
+ P+ P AMK +M K+T FE HEIF YP++Y+LG NA+K + +T NN G+DD+QGSY+ V DH+AYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL KR F +S PRYC V + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K
Sbjct: 151 ATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN------------GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT--LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR-LPKPPTGEKTSVK 551
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5ZIU3|DYRK2_CHICK (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus OX=9031 GN=DYRK2 PE=2 SV=1) HSP 1 Score: 478.019 bits (1229), Expect = 3.075e-161 Identity = 256/420 (60.95%), Postives = 317/420 (75.48%), Query Frame = 1
Query: 127 LNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
+ P AMK +M K+T FE +EIF Y ++Y+LG NA+K + + NN C G+DD+QGSYI V DHIAYRYEV+K+IGKGSFGQVVKAYDHK+ +VALK+VRNEKRF RQAAEEIRILEHL++ DK++ N++H+ E+FTFR+H+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+CMIELLG+P LL + KR F +S PRYC + + L G ++RGK RGPP S+ N LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K T
Sbjct: 79 MTPEQAMKQYMQKLTTFEHNEIFGYTEIYFLGPNAKKRQGVIGGPNN----C--------GYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNNMNVIHMLENFTFRSHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSPKLLDSSKRAKNFVSSKGYPRYCTITT--LSDGSIILNGGRSRRGKLRGPPESREWGNALKGC-DDPLFLDFLKQCLEWDPAIRMTPSQALRHPWLRRR-LPKPPTGEKASAKRITEST 482
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q922Y0|DYRK3_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Mus musculus OX=10090 GN=Dyrk3 PE=1 SV=1) HSP 1 Score: 445.277 bits (1144), Expect = 1.116e-147 Identity = 237/400 (59.25%), Postives = 295/400 (73.75%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
PL P A+K + + +T +E+ EI YP++Y++G NA+K + + NN G+DD G+YIHV DH+AYRYEV+K+IGKGSFGQV + YDHKL YVALK+VRNEKRF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +L+ELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RS+ KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGEDE DQL+CMIELLG+PP LL KR F S +PRYC V+ L G ++RGK RGPPGSK LK G D LF++F++R L ++P R+ P +A++H WI +
Sbjct: 139 PLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNN------------GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQ--TDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCG-DYLFIEFLKRCLQWDPSARLTPAQALRHPWISK 523
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q9XTF3|MBK2_CAEEL (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 OS=Caenorhabditis elegans OX=6239 GN=mbk-2 PE=1 SV=1) HSP 1 Score: 452.595 bits (1163), Expect = 1.710e-147 Identity = 238/398 (59.80%), Postives = 300/398 (75.38%), Query Frame = 1
Query: 133 PRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
P A++ F K+ FE++EI+ Y +V+++G +A+K + NN G+DDE GSY V+ DHIAYRYEV+K+IGKGSFGQV+KA+DHK YVALK+VRNEKRF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NL+ELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+ +IELLG+PP L KR F TS PRYC P + L G+ +KRGK RGPP S+S LK G D LFVDF++R LD++PETRM P +A+KH+W+RR+
Sbjct: 395 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANN------------GGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALKNMG-DELFVDFLKRCLDWDPETRMTPAQALKHKWLRRR 777
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: V4A1L8 (Protein kinase domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_123164 PE=4 SV=1) HSP 1 Score: 503.056 bits (1294), Expect = 4.332e-168 Identity = 260/403 (64.52%), Postives = 317/403 (78.66%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
S ++P +AMK +M+K++ FE HEIF YPQ+Y++GQNA+K + + +N NG+DDE GSY+HV DHI+YRYEV+K+IGKGSFGQVVKAYDHK G ++ALK+VRNEKRF RQA EEIRILEHL++ DKE+ NIVH+ EHFTFRNH+CITFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL +N+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QR+YTYIQSRFYRAPEVILG KYG+ IDMWS GCILAEL+TGYPLFPGEDE DQL+C+IELLG+PP +L KR F +S PRYC V P + L G ++RGK RGPPGSK + LK +DP+F+DF+RRSLD++P RM P +A++H W+RR+
Sbjct: 103 SNSMSPEVAMKQYMHKLSSFEHHEIFNYPQIYFVGQNAKKRQGVVGAASN------------NGYDDENGSYVHVPHDHISYRYEVLKVIGKGSFGQVVKAYDHKAGAHIALKMVRNEKRFHRQAQEEIRILEHLKKQDKENTMNIVHMLEHFTFRNHICITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDALYRNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGTKYGMAIDMWSLGCILAELLTGYPLFPGEDEGDQLACIIELLGMPPQKILDVSKRARNFISSKGYPRYCSVTTLPDGSVV--LNGGRSRRGKPRGPPGSKELVTALKGC-DDPMFIDFMRRSLDWDPNVRMNPSQALRHPWLRRR 490
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: K1QR76 (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Crassostrea gigas OX=29159 GN=CGI_10020062 PE=4 SV=1) HSP 1 Score: 499.59 bits (1285), Expect = 8.254e-167 Identity = 263/417 (63.07%), Postives = 318/417 (76.26%), Query Frame = 1
Query: 76 NSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
S A + RN ++P AMK +M+K+T FE HEIF YP ++++GQNA+K + + NN NG+DDE GSYIHV DHI YRYEV+K+IGKGSFGQVVKAYDHK+ +++ALK+VRNEKRF RQA EEIRILEHL++ DK++ NIVH+ EHFTFRNH+CITFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPLFPGEDE DQL+C+IEL G+PP LL KR F +S PRYC V P ++ L G ++RGK RGPP SK + LK DPLF+DF++R LD++P TRM P +A++H W+RR+
Sbjct: 91 GSKTGSAAARRN---NSMSPESAMKQYMHKLTSFEHHEIFNYPSIFFVGQNAKKRQGVVGGANN------------NGYDDENGSYIHVPHDHIGYRYEVLKVIGKGSFGQVVKAYDHKINSHIALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNAMNIVHMLEHFTFRNHICITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDALYKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGAKYGMPIDMWSLGCILAELLTGYPLFPGEDEGDQLACIIELQGMPPQKLLDQSKRARNFISSKGFPRYCTVTTLPDGSTV--LNGCRSRRGKPRGPPSSKEMVTALKGC-EDPLFLDFMKRCLDWDPSTRMTPGQALRHPWLRRR 489
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A076G429 (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Cerebratulus lacteus OX=6221 PE=2 SV=1) HSP 1 Score: 498.434 bits (1282), Expect = 3.704e-166 Identity = 260/403 (64.52%), Postives = 315/403 (78.16%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
S ++P AMK +M+K++ FE HEIF YPQ+Y++G NA+K + + NN NG+DD+QGSY+H+ DHI+YRYEV+K+IGKGSFGQVVKAYDHK +VALK+VRNEKRF RQA EEIRILEHL++ DK++ NI+HI EHF FRNH+CITFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TGYPLFPGEDE DQL+C+IELLG+PP LL KR F +S PRYC V P ++ L ++RGK RGPPGSK + LK +DPLF+DF+RR LD++P TRM P +A++H W+RR+
Sbjct: 119 SSAVSPETAMKQYMHKLSSFEHHEIFNYPQIYFVGHNAKKRQGVIGGPNN------------NGYDDDQGSYVHIPHDHISYRYEVLKVIGKGSFGQVVKAYDHKSNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHITEHFVFRNHICITFELLSMNLYELIKKNKFQGFSLQLVRKFAHSILQCLDALNKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGAKYGMPIDMWSLGCILAELLTGYPLFPGEDEGDQLACVIELLGMPPQKLLDQSKRARNFISSKGYPRYCTVTTLPDGSTV--LGPGRSRRGKTRGPPGSKEMVTGLKGC-DDPLFLDFMRRCLDWDPATRMSPGQALRHAWLRRR 506
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A4W6CXM1 (Protein kinase domain-containing protein OS=Lates calcarifer OX=8187 GN=dyrk2 PE=4 SV=1) HSP 1 Score: 498.434 bits (1282), Expect = 1.037e-165 Identity = 259/417 (62.11%), Postives = 319/417 (76.50%), Query Frame = 1
Query: 76 NSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK 1326
S S ++ P PL+P AMK FM+K++ FE HE+F YP+VY++G NA+K + NN G+DD+QGSYIHV DHIAYRYEV+K+IGKGSFGQVVKA+DHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLD+L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+C+IELLG+P LL KR F +S PRYC V P ++ L G ++RGK RGPPGSK LK +DPLF+DF+++SL+++P RM P +A++H W+RR+
Sbjct: 119 GSATSNKSTDSKPKPNPLSPEQAMKQFMSKMSSFEHHEVFSYPEVYFVGPNAKKRSGVMGGANN------------GGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKSQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLPDGTTV--LNGGRSRRGKVRGPPGSKDWSAALKGC-DDPLFLDFLKQSLEWDPALRMTPSQALRHPWLRRR 520
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Match: A0A0S7H005 (DYRK2 (Fragment) OS=Poeciliopsis prolifica OX=188132 GN=DYRK2 PE=3 SV=1) HSP 1 Score: 492.271 bits (1266), Expect = 2.998e-165 Identity = 261/413 (63.20%), Postives = 316/413 (76.51%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKC--IPVKQIGEK 1356
P++P LAMK +M+K++ FE HE+F YP+VY++GQNA+K + NN G+DDEQGSYI V D IAYRYEV+K+IGKGSFGQVVKA+DHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ EHFTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDESDQL+C+IELLG+P LL KR F +S PRYC V P + L G ++RGK RGPPGSK LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ P GEK
Sbjct: 8 PMSPDLAMKQYMSKLSSFEHHEVFSYPEVYFIGQNAKKRNGILGAANN------------GGYDDEQGSYIQVPHDQIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMMEHFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDESDQLACIIELLGMPNPKLLEVSKRAKNFVSSKGFPRYCTVTTMPDGSVV--LNGGRSRRGKTRGPPGSKDWSAALKGC-DDPLFLDFLKQCLEWDPALRMTPSQALRHPWLRRRLPKPPSGTTGEK 405
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:103042530]) HSP 1 Score: 487.263 bits (1253), Expect = 6.380e-165 Identity = 265/445 (59.55%), Postives = 327/445 (73.48%), Query Frame = 1
Query: 52 ETT*MMIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESENGT 1386
ETT G+S ++T + P PL P AMK +++K++ FE EIF YP+++++G NA+K N G+DD+QGSYIHV DHIAYRYEV+K+IGKGSFGQVVKAYDHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLD+L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE DQL+C+IELLG+P LL + KR F +S PRYC V P L G ++RGK RGPPGSK LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P GEK+ K GT
Sbjct: 115 ETTQCRQGSSTSIKSTDSK-PKPAPLTPEQAMKQYLSKLSTFEHQEIFNYPEIFFVGPNAKK------------RPGVVGGSNNGGYDDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIELLGMPSQKLLDSSKRAKNFISSKGYPRYCTVTSLP--DGTVALNGGRSRRGKLRGPPGSKDWVTALKGC-DDPLFLDFLKQCLEWDPTLRMTPSQALRHPWLRRR-LPKPPTGEKTTVKRITEGT 542
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 459.914 bits (1182), Expect = 3.147e-154 Identity = 245/413 (59.32%), Postives = 305/413 (73.85%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSF 1362
PL A+K + ++T EQ E+ Y +++++G NA+K + + NN C G+DD+QG YIHV DHIAYRYE +K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL++++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TGYPLFPGEDE DQL+CM+ELLG+PP LL KR F S PRYC V + L GS ++RGK RGPPGSK LK +DP F+DF+R+ LD+ P TRM P A++H W+ ++ GEK+
Sbjct: 135 PLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNN----C--------GYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTT--LSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGC-DDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRLPKPVPSGEKTM 532
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 459.144 bits (1180), Expect = 4.136e-154 Identity = 245/413 (59.32%), Postives = 305/413 (73.85%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSF 1362
PL A+K + ++T EQ E+ Y +++++G NA+K + + NN C G+DD+QG YIHV DHIAYRYE +K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL++++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TGYPLFPGEDE DQL+CM+ELLG+PP LL KR F S PRYC V + L GS ++RGK RGPPGSK LK +DP F+DF+R+ LD+ P TRM P A++H W+ ++ GEK+
Sbjct: 127 PLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNN----C--------GYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTT--LSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGC-DDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRLPKPVPSGEKTM 524
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 384.415 bits (986), Expect = 2.420e-124 Identity = 218/436 (50.00%), Postives = 294/436 (67.43%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWI--------RRKCIPVKQIG-----EKSFQKESENGTCQ 1392
P++P A+K+F +++T +EQ EI Y +++YLG + +K E C + N+G+DDE GSY+ VL DHIAYRYEV+++IGKGSFGQV+K DHK VA+KI+RN+KRF +QA E++IL+ +++ D++S N++H+ E+F FRNH+CI+FELL NL+ELIKKN F+GFSL L+R+FA S+L+CL L + +IIHCDLKPENILL + +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TGYPLFPGE E +Q++C++E++G+PP + + R FF S PR +GK R P SK + + LKT NDPLF+DFIRR L ++P RM P E M+H+WI R K PV++ G E +F++ S N T +
Sbjct: 138 PMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKI-----------EGCQGSPQ-NSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVT-----------------NSKGKKRR-PNSKELASVLKT--NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITEGRLTRLRPKTRPVRKPGDSDNYEYTFRRSSTNRTVE 541
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 384.03 bits (985), Expect = 2.795e-124 Identity = 218/436 (50.00%), Postives = 294/436 (67.43%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWI--------RRKCIPVKQIG-----EKSFQKESENGTCQ 1392
P++P A+K+F +++T +EQ EI Y +++YLG + +K E C + N+G+DDE GSY+ VL DHIAYRYEV+++IGKGSFGQV+K DHK VA+KI+RN+KRF +QA E++IL+ +++ D++S N++H+ E+F FRNH+CI+FELL NL+ELIKKN F+GFSL L+R+FA S+L+CL L + +IIHCDLKPENILL + +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TGYPLFPGE E +Q++C++E++G+PP + + R FF S PR +GK R P SK + + LKT NDPLF+DFIRR L ++P RM P E M+H+WI R K PV++ G E +F++ S N T +
Sbjct: 130 PMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKI-----------EGCQGSPQ-NSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVT-----------------NSKGKKRR-PNSKELASVLKT--NDPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITEGRLTRLRPKTRPVRKPGDSDNYEYTFRRSSTNRTVE 533
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 461.84 bits (1187), Expect = 4.314e-156 Identity = 250/408 (61.27%), Postives = 309/408 (75.74%), Query Frame = 1
Query: 112 PLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIK-VIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCI 1332
P S ++P AM+ +M+++++FE HEIF Y +VY++G +A+K R+ T N NNGFDDEQGSYIHV DH+AYRYEV+++IGKGSFGQVVKAYDH+ YVALK+VRNEKRF RQAAEEIRILEHL++ DKE+ N++H+ E F FRNH+C+TFELL+ NL+ELIKKNKF+GFSL +VRKFA SIL CL+AL KN+IIHCDLKPENILLR RS IK +IDFGSSCYE+QRVYTYIQSRFYRAP GG+YGLPIDMWS GCILAEL+TG PL PGEDE DQL+C +EL G PP LL KR +FF+S PRYC V P P + L G T+RGK RGPP S+ LK +D LF+DF+++ LD++P TR+ P +A+KH W+RR+ +
Sbjct: 99 PHSTAMSPEQAMRKYMHRLSMFEHHEIFNYHEVYFVGPSAKK-RQATLSGVN-----------NNGFDDEQGSYIHVPHDHVAYRYEVLRVIGKGSFGQVVKAYDHRTHQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKENTMNVIHMLESFNFRNHICMTFELLSMNLYELIKKNKFQGFSLQVVRKFAHSILLCLNALHKNRIIHCDLKPENILLRQQGRSGIKIIIDFGSSCYEHQRVYTYIQSRFYRAP----GGRYGLPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELTGSPPARLLEQSKRARQFFSSLGHPRYCTVTTLPGGPVV--LNGGRTRRGKLRGPPSSRDWTTALKGC-DDHLFIDFLKKCLDWDPATRLTPSQALKHPWLRRRPL 487
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 445.662 bits (1145), Expect = 9.056e-150 Identity = 237/399 (59.40%), Postives = 298/399 (74.69%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQW 1314
S+ +P A++ + K+T +E EI+ Y ++Y++G NA+K + +N C G+DDEQGSY+HV DH+AYRYEV+K+IGKGSFGQVVKA+DHK +VALK+VRNEKRF RQAAEEIRILEHL++ D+E+ NI+H+ E FTFR HVC+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLD L +N+IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEV+LG +YG PIDMWS GCILAEL+TG PL PGEDE DQL+C +ELLG+PP LL KR+ F +S PRYC V E P + L ++RGK RGPPGS+ + L+ +DPL +DF+R L++ P R+ P +A++H W
Sbjct: 91 SQLASPDQAVRLYGQKLTAYEHQEIYNYAEIYFVGHNAKKRPGVVGGASN----C--------GYDDEQGSYVHVAHDHVAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRENSMNIIHLLESFTFRGHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILLKQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLGMPPQRLLAQGKRSRNFVSSRGHPRYCGVTEAPDGAVV--LNAGRSRRGKPRGPPGSRELPAALRGC-DDPLLLDFLRGCLEWEPSERLTPAQALRHPW 474
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 251.136 bits (640), Expect = 3.780e-73 Identity = 153/329 (46.50%), Postives = 213/329 (64.74%), Query Frame = 1
Query: 364 RYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFF--TSDCIPRYCEVAEDPFNPSMNKLKGSFTKR-----GKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
RYE+ LIGKGSFGQVVKAYDH+ +VA+KI++N+K F QA E+R+LE + ++D + K IVH+ HF FRNH+C+ FELL+ NL++L++ FRG SL L RKFA + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G +E DQ++ ++E+LGLPP ++L + K+F SD + + S + K + +++ G G PG + + T + F D I R LD++P+TR+ P A++H + ++
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTDMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKARKYFERLSDGSWTVKKTKD-----SKREYKTAGSRKLHDIIGVESGGPGGRRMGEAGHTVADYLKFKDLILRMLDYDPKTRITPFYALQHNFFKK 484
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007958.1 (pep scaffold:Pmarinus_7.0:GL476685:157443:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 213.386 bits (542), Expect = 6.599e-64 Identity = 137/328 (41.77%), Postives = 191/328 (58.23%), Query Frame = 1
Query: 340 VLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAE-EIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIR 1320
V +H+ YRYEV++++G+GSFG+V+K DHK +VA+K++ N RF EI IL+ LQ + SK I+ + EHF+FR C+ FELLN NL +K +GF L +VR FAIS+L+ L+ L +IH DLKP NI + +K+ DFG SC++++ +T IQ+R YRAPEVIL Y P DMWS GC LAEL +G LFPG DQL ++E+ GLPP +++ + FF P + +N RG R PGS+++ L+T D F DFIR L ++PE R+ P AM H+W+R
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFA----------ITKPTHWDIN------NHRGLVR-VPGSRALPLALRT--TDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVR 307
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007952.1 (pep scaffold:Pmarinus_7.0:GL476685:157428:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007952.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 212.616 bits (540), Expect = 1.368e-63 Identity = 139/333 (41.74%), Postives = 195/333 (58.56%), Query Frame = 1
Query: 340 VLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAE-EIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIP 1335
V +H+ YRYEV++++G+GSFG+V+K DHK +VA+K++ N RF EI IL+ LQ + SK I+ + EHF+FR C+ FELLN NL +K +GF L +VR FAIS+L+ L+ L +IH DLKP NI + +K+ DFG SC++++ +T IQ+R YRAPEVIL Y P DMWS GC LAEL +G LFPG DQL ++E+ GLPP +++ + FF C+ + N +N RG R PGS+++ L+T D F DFIR L ++PE R+ P AM H+W+R +P
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFA-------CK--DFSSNVRLN--------RGLVR-VPGSRALPLALRT--TDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVRAPRMP 311
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 211.075 bits (536), Expect = 7.057e-59 Identity = 158/440 (35.91%), Postives = 243/440 (55.23%), Query Frame = 1
Query: 301 NNGFDDEQGSYIHVLSDHIAY----RYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHL-QQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFF-------TSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPG-------SKSICNDL----KTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRK-----------CIP-VKQIGEKSFQKESENGTCQDILATAIDVEFSNKNDSSGTMSATD-GILETTKQFTFNEIS 1512
NNGFD+ YI ++D + +Y V+ ++G+G+FGQVVK + +A+K+V++ + Q+ E +ILE L Q+ D +K + + +Y+ F +NH+C+ FELL+NNL+EL+K+NKF G S+ L+R F IL L L+++++IHCDLKPENILL ++ +K+IDFGSSC E + VYTYIQSRFYRAPE+ILG Y IDMWS GCI+AEL G P+FPG E +QL+ +I+ LG PP ++ K + KF +S ++ + F N ++ + K+R P KSI N + N + F+ L+ NP R P++AM H +I ++ +P + + + ++SE G+ D A N + ++G + D G + K+ T +IS
Sbjct: 343 NNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPPGSSLPGPSEKHDDAKGQQSEYGSANDSSNNAGHNYVYNPSSATGGADSVDIGAISKRKENTSGDIS 782
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 121.324 bits (303), Expect = 7.790e-31 Identity = 93/327 (28.44%), Postives = 160/327 (48.93%), Query Frame = 1
Query: 364 RYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVR--NEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCIT----XXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTY---IQSRFYRAPEVILGGK-YGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQW 1314
+++ ++ +G G++ V K + G YVALK V+ +E+ A EI +++ L+ NIV +Y+ N + + L + N RG L LV+ F +LQ L +N+I+H DLKP+N+L+ R +K+ DFG + V T+ + + +YRAP+V++G + Y ID+WS GCILAE++TG PLFPG ++ +QL + +++G P +L + + +P+Y NP++ + R P + + D +DF+ L NP+ R+ ++A+ H W
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK---------LPKY--------NPNIQQ-----------RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 126.331 bits (316), Expect = 1.292e-30 Identity = 78/263 (29.66%), Postives = 134/263 (50.95%), Query Frame = 1
Query: 316 DEQGSYIHVLSDHIAY--RYEVVKLIGKGSFGQVVKAYDHKL-GNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILL------------------------------RHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCM 1005
D+ G Y++ +D R+ V L+G+G+FG+V+K D+K NYVA+K++R R+ A E+RIL+ + D + + + + E F ++NH+C+ +L ++++ + N F ++ A +++ + L IIH DLKPENIL+ + + IK+IDFGS+ + + I +R YRAPE++LG + P D+WS C+L ELV G L+P + + ++ M
Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMM 556
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 115.546 bits (288), Expect = 2.026e-28 Identity = 101/341 (29.62%), Postives = 167/341 (48.97%), Query Frame = 1
Query: 355 IAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVR--NEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHF----TFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVL---VRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFG-SSCYENQR---------VYTYIQSRFYRAPEVILG-GKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWI 1317
I +Y++V LIG+G++G V A G VA+K ++ ++K F + EI++L + +++ NI+ I + + + E L + + N+ GFS + V+ F IL+ L ++ Q+IH D+KP N+LL + +KV DFG + C + + Y+ +R+YRAPE++L +Y +D+WS GCILAE+V+G PLFPG D QL ++E+LG T F ED FN +K + R P +++ + KT N P +D + + L FNP+ R+ EA++H ++
Sbjct: 9 IPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLN--SNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLG------------TPSF-------------ED-FNQIKSKRAKEYIANLPMRPPLPWETVWS--KTDLN-PDMIDLLDKMLQFNPDKRISAAEALRHPYL 313
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 105.145 bits (261), Expect = 1.374e-24 Identity = 94/327 (28.75%), Postives = 152/327 (46.48%), Query Frame = 1
Query: 355 IAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVR---NEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFT--FRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGG-KYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGP-PGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQW 1314
I RY + +G G+FG V A D VA+K + + ++ E+++L+HL+ N++ + + F + +T + L + + F V+ F IL+ L + +IH DLKP NIL+ +K+ DFG + ++ ++ Y+ +R+YRAPE++L KY + +D+WS GCI AE++ G PLFPG+D Q S + +LLG P D I C S N LK F +R P P S+ KT +P VD + + L F+P+ R+ +A+ H +
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHE------NLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQF----VQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN--ENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSP---------------PKDVINTIC---------SENTLK--FVTSLPHRDPIPFSER----FKTV--EPDAVDLLEKMLVFDPKKRITAADALAHPY 301
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 474.552 bits (1220), Expect = 6.096e-161 Identity = 249/406 (61.33%), Postives = 305/406 (75.12%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIP 1335
S +AMK +M+K++ +E HEIF Y Q+Y++G+ A+K + + NN C G+DDEQGSYIHV DHIAYRYEV+K+IGKGSFGQVVKA DHK +VALK+VRNEKRF RQA EEIRILEHL++ DK++ NI+H+ EHFTFRNHVC+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QR+YTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TGYPLFPGEDE DQL+C +ELLG P L KR F S PRYC + P + G ++RGK RG P SK+ LK +D +F+DF++R L+++P RM P +A++H W+RR+ +P
Sbjct: 96 SRSFTAEVAMKQYMHKLSGYETHEIFNYSQIYFVGEAAKKRQGVVGGANN----C--------GYDDEQGSYIHVPKDHIAYRYEVLKIIGKGSFGQVVKALDHKTNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHMLEHFTFRNHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRAKNFINSKGYPRYCTITTLPDGSVA--VSGGRSRRGKTRGAPNSKTFVQALKGC-DDAMFIDFLKRCLEWDPSARMTPSQALRHPWLRRRALP 486
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 357.066 bits (915), Expect = 3.278e-118 Identity = 201/368 (54.62%), Postives = 264/368 (71.74%), Query Frame = 1
Query: 160 NKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLD 1263
++IT FEQ EI YP+V++LG +A+K + P + N N +DD+ GSY+ L DH+AYRYEV++++GKGSFGQVVKA DHK G +VA+KI+RN+KRF +QA E++IL++L++ DK++ N++H+ EHF FRNH+CITFEL+ NL+ELIKKN F+GFSL L+R+FA ++L CL + K +IIHCDLKPENILLR ++SIKVIDFGSSCYE+QRVYTYIQSRFYR+PEVILG Y + IDMWSFGCILAEL TGYPLFPGE+E +QL+C++E+LGLP L+ + R FF S IPR +GK R P S+ I LKT ND LF+DF+++ L+
Sbjct: 3 DRITTFEQSEILDYPEVWFLGLDAKKI-------DGVPGAPQN-----NNYDDDNGSYLKALHDHLAYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKDNTHNLIHMIEHFYFRNHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILLRQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASRRRLFFDSKGIPRCIT-----------------NSKGKKR-RPSSRDISAALKT--NDALFLDFLKQCLE 338
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 245.743 bits (626), Expect = 4.430e-74 Identity = 155/351 (44.16%), Postives = 220/351 (62.68%), Query Frame = 1
Query: 295 EFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDAL--EKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFF------TSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRR 1323
++N+G+DDE YI + RYE+ LIGKGSFGQV KAYDH+ ++A+KI++N+K F QA E+++LE + + D + K IV + HF +RNH+C+ FELL+ NL++L++ FRG SL L RKFA + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G +E DQ+ ++E+LG+PP ++L N + KFF + C+ + + ++ +P KL G G PG + + T + F D I R LD++ +TR+ P A+ H + ++
Sbjct: 55 QYNDGYDDENYDYIVKAGEKWFDRYEIESLIGKGSFGQVCKAYDHQEKEHIAVKIIKNKKPFLNQAQIEVKLLELMNKNDPDGKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLCSPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFFDRLPDGSYQCL-KVKDGVKEYLSPGSRKLHDIL---GCETGGPGGRRLGEAGHTLQDYLKFKDLILRMLDYDRKTRIVPYAALHHCFFKK 401
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 166.392 bits (420), Expect = 9.518e-46 Identity = 125/338 (36.98%), Postives = 184/338 (54.44%), Query Frame = 1
Query: 373 VVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSS--IKVIDFGSSCYENQRV-YTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPP--GSKSICNDL----------KTAGNDPL--------FVDFIRRSLDFNPETRMKPREAMKHQWI 1317
V++ +G+G+FGQVVK + VA+KI+++ + RQ EI IL L + E+ N V E F +NH C+ FE+L NL++ +K++KF L +R +L L L +IH DLKPENI+L ++ +KVIDFGS+ + ++ V TY+QSR+YRAPEVILG + IDMWS GC++AEL G+PL+PG E DQ+ +I+ GLP +LL N +T++FF I + V E KLK + + + P K I N L GN+ + FV ++R L + E R+ P EA+ HQ++
Sbjct: 1 VLEFLGRGTFGQVVKCWKKGTNELVAIKILKDHPSYARQGQIEISILAKLSAENSEAY-NFVRAIECFQHKNHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIMLVDPDKQPFRVKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQGLPYDHLLNNATKTSRFF-KKAINTHTGVLE-------WKLKNANEHERETKIPSKEARKYIFNSLDDIAQVNLSSSLTGNERIAEKIDRYEFVSLLKRMLTIDQEKRITPEEALSHQFV 329
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 157.532 bits (397), Expect = 8.562e-42 Identity = 109/361 (30.19%), Postives = 189/361 (52.35%), Query Frame = 1
Query: 283 SNLEE--FNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILL-----------------RHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKH 1308
S+ EE ++ DDE G I+ D + RYEV L+G+G+FG+V++ YD K G+ VA+K+++N +++ A EI++LE + Q ++ K + + + F H+C+ FE + ++F+ +K N + + L VR + ++ + L + ++ H DLKPEN+L R++ S +++IDFGS+ +E++ T + +R YRAPEVIL + P D+WS GCI+ EL TG+ LF + + L+ M ++G P + ++T F+ E E K S K + P K + +D + LF + + L+++PE R+ +EAM+H
Sbjct: 95 SHAEERCYSTSRDDEDGHLIYHKGDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDVVAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSLCIKMLDWFNHHGHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPSDFAKKSRKTKYFYKGK-----LEWDE----------KSSSGKYVRENCKPLKKYMLSD---SEGHQLFFNLLDYLLEYDPEKRITAKEAMQH 437
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:101170635]) HSP 1 Score: 481.871 bits (1239), Expect = 5.231e-163 Identity = 255/435 (58.62%), Postives = 319/435 (73.33%), Query Frame = 1
Query: 76 NSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQKESEN 1380
+S S + P + PL AMK FM+K++ FE HE+F + +VY++G +A+K + NN G+DD+QGSYI V DHIAYRYEV+K+IGKGSFGQVVKA+DHK +VALK+VRNEKRF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TGYPL PGEDE+DQL+C+IELLG+P +L KR F +S PRYC V + L G ++RGK RGPPGSK LK +DPLF+DF+++ L+++P RM P +A++H W+RR+ +P G K S +
Sbjct: 108 SSATSNKPADSKPKTNPLTAEQAMKQFMSKMSSFEHHEVFSFSEVYFIGPSAKKRSGVLGGPNN------------GGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRAKNFVSSKGYPRYCTVTT--LSDGTTVLNGGRSRRGKVRGPPGSKVWSTALKGC-DDPLFLDFLKQCLEWDPAHRMTPSQALRHSWLRRR-LPKPPTGTTPGDKTSSS 526
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 452.21 bits (1162), Expect = 7.535e-152 Identity = 243/412 (58.98%), Postives = 303/412 (73.54%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKS 1359
PL P A++ + ++++ E EI YP VY++G NA+K + NN C G+DDEQG YIHV DH+AYRYE +K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TGYPLFPGEDESDQL+C +ELLG+PP +L KR F S PRYC P ++ L GS ++RGK RGPP SK LK DP F+DFI++ LD++P +R+ P +A++H W+ R+ + EK+
Sbjct: 91 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNN----C--------GYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALKGC-EDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLPKPLAVTEKN 487
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 453.366 bits (1165), Expect = 2.003e-151 Identity = 243/412 (58.98%), Postives = 303/412 (73.54%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKS 1359
PL P A++ + ++++ E EI YP VY++G NA+K + NN C G+DDEQG YIHV DH+AYRYE +K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TGYPLFPGEDESDQL+C +ELLG+PP +L KR F S PRYC P ++ L GS ++RGK RGPP SK LK DP F+DFI++ LD++P +R+ P +A++H W+ R+ + EK+
Sbjct: 149 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNN----C--------GYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALKGC-EDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLPKPLAVTEKN 545
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 453.366 bits (1165), Expect = 2.003e-151 Identity = 243/412 (58.98%), Postives = 303/412 (73.54%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKS 1359
PL P A++ + ++++ E EI YP VY++G NA+K + NN C G+DDEQG YIHV DH+AYRYE +K+IGKGSFGQV K YDHKL ++ALK+VRNEKRF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NL+ELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TGYPLFPGEDESDQL+C +ELLG+PP +L KR F S PRYC P ++ L GS ++RGK RGPP SK LK DP F+DFI++ LD++P +R+ P +A++H W+ R+ + EK+
Sbjct: 149 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNN----C--------GYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALKGC-EDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRLPKPLAVTEKN 545
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 369.392 bits (947), Expect = 8.580e-119 Identity = 218/472 (46.19%), Postives = 299/472 (63.35%), Query Frame = 1
Query: 124 PLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIP-VKQIGEKSFQKESENGTCQDILATAIDVEFSNKNDSSGTMSATDGILETTKQFTFNEISGISAAVTD 1536
P++P A+ F ++T FEQ EI Y +V++LG +QK + P N+G+DDE GSYI VL DHIAYR+EV+++IGKGSFGQV+K DHK VA+K++RN+KRF QA E++ILE +++ DK++ N++H+ E+F FRNH+CI+FELL NL+ELIKKN F+GFSL L+R+FA ++L+CL L K +IIHCDLKPENILL +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TGYPLFPGE E +Q++C++E+LG+PP + + + R FF S PR +GK R P SK + LKT DPLF++FI+ L ++P RM P E ++HQWI V+ + + +K S+ T D A + + S +++S ++ D +K + + I A+ D
Sbjct: 131 PMSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQK----IEGSQGAPH--------NSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNLHNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNPRNIT-----------------NSKGKKRR-PNSKELSAALKTT--DPLFLEFIKGCLTWDPTKRMTPDEGLQHQWILEGNFNRVRSRAKTTVKKTSDTSTSADRQANSKSEKVSPESNSKESLR-RDSSTGESKMASVERLRPIGASAED 569
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076586.1 (SMESG000076586.1) HSP 1 Score: 581.252 bits (1497), Expect = 0.000e+0 Identity = 298/298 (100.00%), Postives = 298/298 (100.00%), Query Frame = 1
Query: 64 MMIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 957
MMIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG
Sbjct: 1 MMIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 298
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076586.1 (SMESG000076586.1) HSP 1 Score: 579.326 bits (1492), Expect = 0.000e+0 Identity = 297/297 (100.00%), Postives = 297/297 (100.00%), Query Frame = 1
Query: 67 MIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 957
MIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG
Sbjct: 1 MIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 297
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076583.1 (SMESG000076583.1) HSP 1 Score: 572.778 bits (1475), Expect = 0.000e+0 Identity = 303/437 (69.34%), Postives = 350/437 (80.09%), Query Frame = 1
Query: 118 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQK----------ESENGTCQDI 1398
S+ P A++ + +T+ EQ EI +PQ+Y+LGQNAQK +RL C EFN+GFDD+QGSYIH+++DHIAYRYEV K+IGKGSFG+V+KAYD+K YVALKI++++ RFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG+PLFPGE+ESDQLSC+ ELLG+P +L +CKR N FF SDC+P+YC V ++ N S+ KL GS+T+RG +RGPP SK I + LK G D F+DF+ R ++ NP TR+KP EAMKH WIR K + E S Q +S+NG C +I
Sbjct: 14 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIY--------CKTEGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNSVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNI 442
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 483.797 bits (1244), Expect = 4.368e-164 Identity = 262/428 (61.21%), Postives = 319/428 (74.53%), Query Frame = 1
Query: 115 LSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQ-----KESENG 1383
+S L+P AM+ FM+K+T +E HEIF YP ++++G NA+K + NN C G+DD+Q SYIHV DHIAYRYEV+KL+GKGSFGQVVKA DHK G VA+K+VRNEKRFTRQAAEEIR+LE L++ D +S CN++HI + F FRNHVC+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SIL CL+ L +N+IIHCDLKPENILL+ RS IKVIDFGSSC E+QR+YTYIQSRFYRAPEVILGGKYG+PIDMWSFGCILAEL TGYP+FPGEDE DQL+C++E+LG PP L CKRT FFTS PRYC + D + LKG +KRG++RGPP SK++ LK +D LF+DF R L + PETRM P+EA+KH W+RRK IP I + + K+ NG
Sbjct: 143 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNN----C--------GYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVI--LKGGRSKRGRFRGPPASKTLSTALKNC-DDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNG 555
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 483.411 bits (1243), Expect = 5.371e-164 Identity = 262/428 (61.21%), Postives = 319/428 (74.53%), Query Frame = 1
Query: 115 LSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITXXXXXXXXXXXXXXXXXRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGYPLFPGEDESDQLSCMIEXXXXXXXXXXXXCKRTNKFFTSDCIPRYCEVAEDPFNPSMNKLKGSFTKRGKYRGPPGSKSICNDLKTAGNDPLFVDFIRRSLDFNPETRMKPREAMKHQWIRRKCIPVKQIGEKSFQ-----KESENG 1383
+S L+P AM+ FM+K+T +E HEIF YP ++++G NA+K + NN C G+DD+Q SYIHV DHIAYRYEV+KL+GKGSFGQVVKA DHK G VA+K+VRNEKRFTRQAAEEIR+LE L++ D +S CN++HI + F FRNHVC+TFELL+ NL+ELIKKNKF+GFSL LVRKFA SIL CL+ L +N+IIHCDLKPENILL+ RS IKVIDFGSSC E+QR+YTYIQSRFYRAPEVILGGKYG+PIDMWSFGCILAEL TGYP+FPGEDE DQL+C++E+LG PP L CKRT FFTS PRYC + D + LKG +KRG++RGPP SK++ LK +D LF+DF R L + PETRM P+EA+KH W+RRK IP I + + K+ NG
Sbjct: 146 MSTCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNN----C--------GYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVI--LKGGRSKRGRFRGPPASKTLSTALKNC-DDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRKQIPGNSITKTKYSNNIDGKDDPNG 558 The following BLAST results are available for this feature:
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001404 ID=SMED30001404|Name=Dual specificity tyrosine-phosphorylation-regulated kinase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2081bpback to top protein sequence of SMED30001404-orf-1 >SMED30001404-orf-1 ID=SMED30001404-orf-1|Name=SMED30001404-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=503bp MMIGNSNDSEATSFRNPLSEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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