DNA replication licensing factor MCM8

Overview


Name	DNA replication licensing factor MCM8
Smed ID	SMED30001391
Length (bp)	2777

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DNA replication licensing factor MCM8 (SMED30001391) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA replication licensing factor MCM8 (SMED30001391) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA replication licensing factor MCM8 (SMED30001391) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA replication licensing factor MCM8 (SMED30001391) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30001391

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
tail region	SMED30001391	SMESG000004906.1	SmedASXL_005494	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
X1 cell	SMED30001391	SMESG000004906.1	SmedASXL_009366	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30001391	SMESG000004906.1	SmedASXL_009366	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X1 cell	SMED30001391	SMESG000004906.1	SmedASXL_005494	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
tail region	SMED30001391	SMESG000004906.1	dd_Smed_v6_22244_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
zeta neoblast	SMED30001391	SMESG000004906.1	dd_Smed_v4_22244_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
neoblast	SMED30001391	SMESG000004906.1	SMED_26504_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001391	SMESG000004906.1	SMED_26504_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001391	SMESG000004906.1	SMED_11330_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001391	SMESG000004906.1	SMED_11330_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001391	SMESG000004906.1	SMED_07904_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30001391	SMESG000004906.1	SMED_07904_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
Match: MCM8 (minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147])

HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0
Identity = 378/803 (47.07%), Postives = 531/803 (66.13%), Query Frame = 1

Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++  +             +S+   + +   +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A      S      C+F L +  N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEG---SRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 839

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Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++  +             +S+   + +   +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A      S      C+F L +  N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEG---SRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 839

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
Match: MCM8 (minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147])

HSP 1 Score: 655.596 bits (1690), Expect = 0.000e+0
Identity = 374/803 (46.58%), Postives = 525/803 (65.38%), Query Frame = 1

Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++  +             +S+   + +   +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A                      N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAE-------------------EANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 823

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
Match: AL035461.4 (novel protein)

HSP 1 Score: 634.795 bits (1636), Expect = 0.000e+0
Identity = 365/786 (46.44%), Postives = 513/786 (65.27%), Query Frame = 1

Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLN 2436
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++  +             +S+   + +   +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A      S      C+F L +  N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+  +   I N L+
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEG---SRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQYENPWTIPNMLS 822

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
Match: MCM8 (minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147])

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 376/843 (44.60%), Postives = 527/843 (62.51%), Query Frame = 1

Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVF-----------ANNISSISNSDLPNI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVA---SLCP------SIYGH-------------------------------ELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++            A    S     + N+ +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A      S      C+F L +  N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V    +L P      +I  H                                LVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEG---SRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 879

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Celegans
Match: mcm-2 (DNA helicase [Source:UniProtKB/TrEMBL;Acc:Q7K7J6])

HSP 1 Score: 297.36 bits (760), Expect = 7.158e-87
Identity = 198/574 (34.49%), Postives = 299/574 (52.09%), Query Frame = 1

Query:  508 INVRIANFSPICKSLN-LQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKS-FEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTE-SASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I VRI+   P+ + +  L+   +   I   G V   + + P    VK+ C+ C       +  + +   PT C +  C+ K  FE   E+  TV  +YQ I +QE+                 +K   GR+P++ + IL+ DL D+C PGDE+ VTG+       S N+ Q        +FN ++H N+I       KM  D       + + +D+ AI  +  +PN+ + + +S+ PSIYGH+ VK ++ LALF G  K    K+R  +RG+ ++L+ GDPG  KSQ L+ A  IAPRSV   G   +  GLT    +        LEAGA+V++D G C IDEFDKMS Q   S+ EAMEQQSISI+KAG+V +L AR +V+AA+NP  G YN  +T AEN+ ++ P+LSRFD++ ++ D  + V D +L++ V+  H     + +   +++ D +    M +  G                 IP  LLRKYI YA++  HP L  + +      +  +RK         IT R +ESM+RL+EA A+  LR   N++D      +MLES +
Sbjct:  257 IKVRISQL-PVEEDIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVACGYLLGPFVQQNDEEVRPTICPS--CQGKGPFELNVEN--TVYHNYQRITMQESP----------------NKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNFDGSLNYKQGFP-----VFNTLIHANHITNKD---KMASD-------QLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHR--LRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHPD-AKKIVKEGDELEEDQMDERTGVRL--------------IPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVAITVRHVESMIRLSEAHAKLHLRSYVNDEDCAAAIRVMLESFV 777

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Query:  508 INVRIANFSPICKSLN-LQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKS-FEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTE-SASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I VRI+   P+ + +  L+   +   I   G V   + + P    VK+ C+ C       +  + +   PT C +  C+ K  FE   E+  TV  +YQ I +QE+                 +K   GR+P++ + IL+ DL D+C PGDE+ VTG+       S N+ Q        +FN ++H N+I       KM  D       + + +D+ AI  +  +PN+ + + +S+ PSIYGH+ VK ++ LALF G  K    K+R  +RG+ ++L+ GDPG  KSQ L+ A  IAPRSV   G   +  GLT    +        LEAGA+V++D G C IDEFDKMS Q   S+ EAMEQQSISI+KAG+V +L AR +V+AA+NP  G YN  +T AEN+ ++ P+LSRFD++ ++ D  + V D +L++ V+  H     + +   +++ D +    M +  G                 IP  LLRKYI YA++  HP L  + +      +  +RK         IT R +ESM+RL+EA A+  LR   N++D      +MLES +
Sbjct:  257 IKVRISQL-PVEEDIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVACGYLLGPFVQQNDEEVRPTICPS--CQGKGPFELNVEN--TVYHNYQRITMQESP----------------NKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNFDGSLNYKQGFP-----VFNTLIHANHITNKD---KMASD-------QLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHR--LRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHPD-AKKIVKEGDELEEDQMDERTGVRL--------------IPQDLLRKYIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVAITVRHVESMIRLSEAHAKLHLRSYVNDEDCAAAIRVMLESFV 777

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Celegans
Match: mcm-4 (DNA replication licensing factor mcm-4 [Source:UniProtKB/Swiss-Prot;Acc:Q95XQ8])

HSP 1 Score: 285.034 bits (728), Expect = 8.654e-83
Identity = 189/571 (33.10%), Postives = 276/571 (48.34%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAE-FSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESM 2214
            I +R  N         L  N +   I++ G V + + + P      F+C  C    I    D  +   P  C N    +  F+ +   + +V +D QV++LQE+  D P                 G  P T++      LV++  PGD + VTGI        N  Q + +         LH           KMD    +  + E  + + +  I  +   P++   L  S+ PSIY H+ VK  LL  LFGG  K     N+  +R   +IL+ GDPG  KSQMLQ    + PRS Y  G   +  GLT S S+D D+    L+ GALV++DNG CCIDEFDKM+    + L E MEQQ++SIAKAG++C L+AR SVLAAANP    +N+ KT+ EN+ +   LLSRFDL+++++D  +E+ D +L  H++SL+ E                                   G++E  +++   LLR YIAYAK  +HPKLS EA+  + E YL +RK            RQLES++RL+EA A+  L +  +  D +    L  E++
Sbjct:  221 IELRPFNAQKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAF-GIESEVDKGRIEEPVVCTN-CSNTHCFQLVH--NRSVFLDKQVVKLQESPDDMP----------------SGETPHTVSVYAHGSLVESVQPGDRITVTGIFRATGMKVNPKQRALASVYRTSIDALHFR---------KMDTSRLHQDNGETITEERIQQIIELSKRPDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHLVSLYFEND---------------------------------GNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMRKAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREAL 729

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Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAE-FSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESM 2214
            I +R  N         L  N +   I++ G V + + + P      F+C  C    I    D  +   P  C N    +  F+ +   + +V +D QV++LQE+  D P                 G  P T++      LV++  PGD + VTGI        N  Q + +         LH           KMD    +  + E  + + +  I  +   P++   L  S+ PSIY H+ VK  LL  LFGG  K     N+  +R   +IL+ GDPG  KSQMLQ    + PRS Y  G   +  GLT S S+D D+    L+ GALV++DNG CCIDEFDKM+    + L E MEQQ++SIAKAG++C L+AR SVLAAANP    +N+ KT+ EN+ +   LLSRFDL+++++D  +E+ D +L  H++SL+ E                                   G++E  +++   LLR YIAYAK  +HPKLS EA+  + E YL +RK            RQLES++RL+EA A+  L +  +  D +    L  E++
Sbjct:  221 IELRPFNAQKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAF-GIESEVDKGRIEEPVVCTN-CSNTHCFQLVH--NRSVFLDKQVVKLQESPDDMP----------------SGETPHTVSVYAHGSLVESVQPGDRITVTGIFRATGMKVNPKQRALASVYRTSIDALHFR---------KMDTSRLHQDNGETITEERIQQIIELSKRPDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHLVSLYFEND---------------------------------GNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMRKAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREAL 729

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Celegans
Match: mcm-6 (DNA replication licensing factor mcm-6 [Source:UniProtKB/Swiss-Prot;Acc:P34647])

HSP 1 Score: 259.61 bits (662), Expect = 7.407e-74
Identity = 196/662 (29.61%), Postives = 326/662 (49.24%), Query Frame = 1

Query:  274 YFSCLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPD---DYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM--------------TESASTNFHQSSGSGSNCLFNLVLHVNNI--------CRLK-------GDVKMDVDSENSYD--AEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTP---ITTRQLESMVRLTEAKAR 2145
            Y S +K   E+++ +K+ I       + +++ K  +      +    R+   MC ALH L   +         +    + V + N     K   L A+++G  + + G +V+ + V P   R  F C  C     V   D    +++  PT+C N  C +++   L  +  T  +D+Q IR+QET ++ P                 G IP+T++ I+  ++V+   PGD+  + G ++               E+++ N  +++           L V ++        C ++       GD    V+  +  D  ++ S +D   ++ +  +  + K +V SL P+IYG+  VK  +LL L GGV K   D+   ++RG+ ++ +VGDP   KSQ+L++    +PR++Y  G + + AGLT +  KD +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISI KAG+   L+AR S+LAAANP  G Y++++ +  N++MSAP++SRFDL ++++D  NEV D  ++R +L  H   S +    S+ ++D                                  ++KYIA+A+ +  PK+S +AA  L   Y  LR        T    IT RQLES+VRL+EA AR
Sbjct:   40 YKSAMK---ELVQPEKNTI-----FINMQHLYKFSNNLATTIELQYYRVYPFMCEALH-LATLDACDESERQQMFKKQLYVSLFNLDAKTKVRELSADKVGGLVRIAGQIVRTHPVHPELSRACFVCEDCG----VTTRDVQQQFRYTQPTKCANPQCMNRTRFSLDVNSSTF-VDFQKIRIQETQAELP----------------RGSIPRTVDVIVRGEMVETVQPGDKCDIVGTLIVIPDIAQLSTPGLRAETSNQNRGRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTESLVGGDASGAVEETDYLDLWSKMSTEDRATLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLLMLLGGVAKKSRDEG-TSLRGDINVCLVGDPSTAKSQVLKAVEEFSPRAIYTSGKASSAAGLTAAVVKDEESFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARASILAAANPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIARRILDNHRAISEHTERDSVYKIDD---------------------------------IKKYIAFARCF-KPKISDKAAETLVREYKKLRMSDSNNAATSSWRITVRQLESLVRLSEALAR 636

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Match: Mcm6 (gene:FBgn0025815 transcript:FBtr0070952)

HSP 1 Score: 297.745 bits (761), Expect = 2.413e-87
Identity = 197/596 (33.05%), Postives = 321/596 (53.86%), Query Frame = 1

Query:  544 KSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKS-KSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM------------TESASTNFHQSSGSGSNCLFNL-VLHVNNI---------------CRLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDS-GTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT--EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTP---ITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGV 2223
            K  +L  ++IG+ I + G VV+ + V P  +   F CL C+ E I  +   +KF  PT C N VC + K F  + + ++++ +D+Q IR+QET ++ P                 G IP+ +  IL  +LV+    GD    TG ++            T + +++ H+  G G + +  L  L +  +                R  G D+ M   +      + +  + + I  +  + NL++ L++SL PSIYG++ VK  +LL  FGGV K   +K   ++RG+ ++ IVGDP   KSQ L+     +PR++Y  G + + AGLT +  +D +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISIA+AG+   L+ARTS+LAAANP  G Y+++K++ +N+++SAP++SRFDL +I++D  NEV+D  ++R ++ LH+  E+S+ R              + T+E                      ++LR Y+ +A+++  P +S EA ++L E Y  LR+R     G     IT RQLESM+RL+EA A+ E      E+  K+   L+ +S++ V
Sbjct:  116 KVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTE-IRNVEQQFKFTNPTICRNPVCSNRKRF--MLDVEKSLFLDFQKIRIQETQAELP----------------RGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKP-GEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKT--SLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVER--------------AYTRE----------------------EVLR-YVTFARQF-KPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRV 651

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Match: Mcm2 (gene:FBgn0014861 transcript:FBtr0081827)

HSP 1 Score: 293.893 bits (751), Expect = 2.134e-85
Identity = 205/633 (32.39%), Postives = 314/633 (49.61%), Query Frame = 1

Query:  328 IIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC-LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            ++ Y DL + E+   V+  F  E  F    I  ++   +   +F       +        I+VRI+    I +    +   +   +   G V     V P    +K+ C+ C       +        P  C    C+S    P     ++T+  +YQ I LQE+    P                 GRIP++ + IL+ DL D C PGDE+ VTGI      + N+  S  +     +F  V+  N++  +  D K  V S        + +D+  I+ +  +P + + +VAS+ PSIYGH+ +K +L LALFGG +K   +K++V  RG+ ++LI GDPG  KSQ L+    +APR+V+  G   +  GLT    ++  S    LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ +S P+LSRFD++ ++ D  + + D +L++ V+  H                      M   P       L     ++ D IP  LLR+YI YAK+ + PKL++   + + + Y  LR+        PIT R +ES++R++EA AR  LRE   E D      +MLES +
Sbjct:  216 VVSYTDLANKEH---VLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTE-------IHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSCPE--CQSTG--PFSINMEQTLYRNYQKITLQESPGRIPA----------------GRIPRSKDVILLADLCDQCKPGDELEVTGIY-----TNNYDGSLNTDQGFPVFATVIIANHV--VVKDSKQVVQS-------LTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKV--RGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSH----------------------MKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFI 780

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Match: dpa (gene:FBgn0015929 transcript:FBtr0345797)

HSP 1 Score: 270.011 bits (689), Expect = 5.380e-77
Identity = 187/578 (32.35%), Postives = 277/578 (47.92%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDEL 2238
            I VR  N        +L    +   IS+ G V++ + V P      F C  C     V + D  +   PT C N  C +     L  +    T D Q+++LQE+  D                   G+ P  +      DLVD   PGD V VTGI       T      G  S+       HV+ +   K D K   + E   D  F  + +  ++ +  +P+++  L  ++ PSIY ++ +K  +LL LFGG  K      R   R   H+L+ GDPG  KSQMLQ    + PRS Y  G   +  GLT   +KD ++    L+ GALV++DNG CCIDEFDKM+    + L E MEQQ++SIAKAG++C L+ARTS+LAAANP    +NK K + +N+++   LLSRFDL++++LD  +E+ D +L+ H++SL+                      +T+             H+E        +LR YIAYA++++ P LS EA   L + Y+ +RK            RQLES++RL+EA A+  L       D ++   L  E++    +D L
Sbjct:  261 IQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEV-DRGRINQPTLCTN--CNTNHCFRLIHNRSEFT-DKQLVKLQESPDDM----------------AAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTG-----GLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYY---------------------VTR-------------HEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPL 779

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Match: dpa (gene:FBgn0015929 transcript:FBtr0088982)

HSP 1 Score: 270.011 bits (689), Expect = 5.380e-77
Identity = 187/578 (32.35%), Postives = 277/578 (47.92%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDEL 2238
            I VR  N        +L    +   IS+ G V++ + V P      F C  C     V + D  +   PT C N  C +     L  +    T D Q+++LQE+  D                   G+ P  +      DLVD   PGD V VTGI       T      G  S+       HV+ +   K D K   + E   D  F  + +  ++ +  +P+++  L  ++ PSIY ++ +K  +LL LFGG  K      R   R   H+L+ GDPG  KSQMLQ    + PRS Y  G   +  GLT   +KD ++    L+ GALV++DNG CCIDEFDKM+    + L E MEQQ++SIAKAG++C L+ARTS+LAAANP    +NK K + +N+++   LLSRFDL++++LD  +E+ D +L+ H++SL+                      +T+             H+E        +LR YIAYA++++ P LS EA   L + Y+ +RK            RQLES++RL+EA A+  L       D ++   L  E++    +D L
Sbjct:  261 IQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEV-DRGRINQPTLCTN--CNTNHCFRLIHNRSEFT-DKQLVKLQESPDDM----------------AAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTG-----GLSSSVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYY---------------------VTR-------------HEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPL 779

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Match: rec (gene:FBgn0003227 transcript:FBtr0334595)

HSP 1 Score: 261.536 bits (667), Expect = 7.580e-74
Identity = 228/819 (27.84%), Postives = 396/819 (48.35%), Query Frame = 1

Query:  190 YHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNLEMIEIKKHAIIDYNDLC-----SSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN----NISSISNSDLPNIY---------INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSK-SFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICG--GSVTTAGLTVSFSKDNDSGTALEAGALVI-SDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT-----------------------EQSLNRSSSSIRQMDTMSF---HSMTKEPGSTFHERLSYGHKES-CDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMD--GTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERS---GSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLL 2484
            Y GW +YF  E+Y E ++   RI A  +Y+       + + I+      +  LC     S   + +V      + + +  R +  + LA+HT+V  +    N S+ +    P  Y         I  R  +F P+     +  +++ +  S++G V  V +         FRC  C+ E  +     ++   P +C    C ++  F PL+ S  T     Q+IR++E+           S ++ HD   E  +P  ++  L  DLVD    G EV+VTGI+  +    +   ++G  SN +   +  V+            +   +S   EFS +DL AI  I++EPN FKLLV S+ P +YGHEL KA+ LL+L GG    G +   +      ++L+VGDPG+GK+++LQS   IA R  ++ G  G+ +   L V+F+  N     L+AG+L++ S  G C +D+ DK++++Q A LL+ ++ + +++  AG   +  A+ SV+A ANP  G Y++ + + +N+ +S  LL  F LVYI+LD+P+E  D  L+ HV +LH                        E SLN  ++  +  DT+     +    +      +RL    +E   D +PP L++K+++YA++ ++P L+ +A+N +  ++L L+   +  +   + I   QL +++ L++A+AR +L  + + Q  +DV  L+ ES+      E G         G     +  S +L + L+    RS   G   F + ++K+I   A I L+    +V   N  G+LL KG   Y+++
Sbjct:  112 YSGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRG---FFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQ-PRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEES-----------SLNLVHD--FETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDD--TTTGDTSNQMQPYLKAVS------------IRDASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGK---GAETEAI------NVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKR--VLQAGSLMMASGGGHCTLDDVDKLASKQ-AVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAG-KDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKE-GSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGI-LTGFSQLVEMANLGGYLLMKGANMYEVV 883

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:ZFIN;Acc:ZDB-GENE-120927-1])

HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0
Identity = 373/804 (46.39%), Postives = 521/804 (64.80%), Query Frame = 1

Query:  148 KVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALH---TLVFANNISSI-SNSDLP-------NI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGI--VMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDV-DSENSYDA-EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDT----MSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +  + + +L   CPY GW +YF  E ++E+S  V +I+ F  YF+  +++L   + IE K   ++DY DL S++ ++  + +   + +   ++I+  + +A+H   TL    + + +    +LP       NI +I+ R+ N+ P+    +L+AN  G F+ ++G VV+V+ +KP+C+++ F C +C + Q V LPD  K+ +PT+C+   C+ +SF P + S  T+T+D+Q I++QE  S               D+   GRIP+T+ C L +DLVD+CVPGD V +TG+  V  E  ST   +       C+F L +  N++   KG     V +SE    + EFS+KDLYAI+ I ++ +LFKL+V SLCP IYGH LVKA L LALFGG  K+ +DKNR+ IRG+ H+LIVGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTVS S+D+ SG  ALEAGALV+ D G CCIDEFDKM + QH +LLEAMEQQSIS+AKAG+VC L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +S   S ++  + +T    +S   ++ E      + L     E+ D IP QLLRKY+ YA+ YVHP LS+EAA +LQ+FYL LRK+    D TPITTRQLES++RLTEA+AR ELRE A + DA+DV E+M  S+   YSDE G L+F RSQ GSGMS  S  KK +S L   +ER+  S F   D++Q+A +  I++ D E  +  LNEQG+LLKKG   Y+L T
Sbjct:   73 QARVTQATLDITCPYKGWRLYFS-EGFVESSPYVEKIKVFEQYFTS-QIDLYDKDEIERKGSILVDYKDLLSNKQVSHSLPDLARDLKEMPEKILDCLGVAIHQVLTLDLERHAAELQGQEELPAGIRPIINIPHISARLYNYEPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDG-KYTMPTKCLQSECRGRSFTPNRSSPFTLTVDWQTIKVQELMSG--------------DQRESGRIPRTIECELTQDLVDSCVPGDMVTITGVIKVSNEEGSTRNKKD-----KCMFLLYIQANSVSNSKGQKSKAVSESEGQGPSVEFSIKDLYAIQEIQAQEDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQGICCIDEFDKMGS-QHQALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGKSGAVSGAAATRFNTHESSISILEVSSE--KPLADTLKLVPGEAFDPIPHQLLRKYVGYARHYVHPTLSAEAAQVLQDFYLELRKQNQTADSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIMKHSLTDTYSDEFGRLDFDRSQLGSGMSNRSKVKKFVSALNKLAERTSKSMFELQDLRQLAKDLQIQVVDFEGFICALNEQGYLLKKGHRMYQLQT 851

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Match: mcm2 (minichromosome maintenance complex component 2 [Source:ZFIN;Acc:ZDB-GENE-020419-24])

HSP 1 Score: 292.738 bits (748), Expect = 7.373e-85
Identity = 200/574 (34.84%), Postives = 290/574 (50.52%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC--LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I+VRI N   + +  +L+   +   I   G V     V P    VK+ C  C            +   P  C     + +S  P +   ++TV  +YQ I +QE+                  K   GR+P++ + IL+ DLVD C PGDE+ +TGI        N +  S + +N   +F  V+  N+I R    V +         AE + +D+ AI A+  +  + + + AS+ PSIY HE +K  L LALFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    +A R+V+  G   +  GLT    +   S    LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H                 +  H   KE G    E +   +      IP +LLRKYI YAK+ V PKL+    + +   Y  LRK        PIT R +ESM+R+ EA AR  LR+   E D      +MLES +
Sbjct:  269 IHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFILGPFFQSQNQEVKPGSC----PECQSLGPFEINMEQTVYQNYQRITIQESPG----------------KVAAGRLPRSKDAILLADLVDMCKPGDEIELTGIY------HNNYDGSLNMANGFPVFATVILANHIARKDEGVAV---------AELTDEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKNPGGKHKV--RGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSH-----------------IKHHPSNKEGGVAGLEEVVLPNTFDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVLEDDVNMAIRVMLESFI 788

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Match: mcm4 (minichromosome maintenance complex component 4 [Source:ZFIN;Acc:ZDB-GENE-030131-9544])

HSP 1 Score: 290.041 bits (741), Expect = 2.808e-84
Identity = 195/569 (34.27%), Postives = 283/569 (49.74%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCK-NEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVK----MDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK---RRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSD 2232
            NL    I   I++ G V++ +Q+ P      FRC  C  N ++ V  D  + A P  C N  C +     L   + +V  D Q+I+LQE+  D P                 G+ P T       DLVD   PGD V +TGI        N  QS       ++    H++ I   K D K    +D D E      F+ + +  ++ + ++P++++ L ++L PSIY HE +K  +LL LFGG  K      R   R   +IL+ GDPG  KSQ+LQ    + PR  Y  G   +  GLT    KD ++    L+ GALV+SDNG CCIDEFDKMS    + L E MEQQ++SIAKAG++C L+ARTS+LAAANP    +N  KT  EN+++   LLSRFDL+++MLD  +E  D +L+ H++SL+ +                              E++   H +        +L+ YIA+A+  VHP+LS EA+  L E Y+ +RK    R  +   P   RQLES++RL EA A+          D ++ K L  E++    +D
Sbjct:  255 NLNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEV--DRGRIAEPAVCRN--CNTTHSMALVH-NRSVFSDKQMIKLQESPEDMPA----------------GQTPHTTVVYAHNDLVDKVQPGDRVNITGIYRAAPMRLNPRQSQ---VKSVYKT--HIDAIHFRKTDEKRLHGLDEDGEQKL---FTKERVALLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQS----------------------------EEQIEEEHLDMA------VLKDYIAFARTTVHPRLSEEASQALIEAYVDMRKIGSGRGMVSAYP---RQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREALKQSATD 757

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Match: mcm6l (MCM6 minichromosome maintenance deficient 6, like [Source:ZFIN;Acc:ZDB-GENE-050913-141])

HSP 1 Score: 281.182 bits (718), Expect = 3.005e-81
Identity = 190/588 (32.31%), Postives = 301/588 (51.19%), Query Frame = 1

Query:  496 PNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM--------------TESAS-----TNFHQSSGSGSNCL------FNLVLHVNNIC----RLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDG-------TPITTRQLESMVRLTEAKAR 2145
            P+    V  + F    K   L   +IG+ + + G VV+ + V P  +   F CL C++  I  +   +K+  PT C N VC ++    + +++++  +D+Q +R+QET ++ P                 G IP+++  IL  + V+    GD    TG ++               E++S       F      G   L      + L    N +     R  G +++ +  +  S   + +V++   +  +  + NL+  L  SL P+I+G++ +K  +LL LFGGV K   +    ++RG+ ++ IVGDP   KSQ L+     APR+VY  G + + AGLT +  KD +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISI KAG+   L+ARTS+LAAANP  G YN+AK++ +N+ MSAP++SRFDL +I++D  NEV D  ++R ++ LH      R+  S+                    ER+      S D I     ++YI +A+++  PK++ EA   + + Y  LR+R    DG         IT RQLESM+RL+E  AR
Sbjct:  100 PSKEFYVAFSEFPSRQKIRELSTVRIGTLLRISGQVVRTHPVHPELVSGTFLCLDCQS-VIKDVEQQFKYTQPTICKNPVCANRR-RFMLDTNKSRFVDFQKVRIQETQAELP----------------RGSIPRSVEVILRAEAVETAQAGDRCDFTGTLIVVPDVSAMALAGTRAETSSRVTGKEGFEADGIQGLKALGVRELSYRLAFLANYVAPTNPRFGGKELRQEDQTAESVKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGILLMLFGGVAKTTMEG--TSLRGDINVCIVGDPSTSKSQFLKHVEDFAPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPIDGRYNRAKSLKQNVNMSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHA-----RNVESV--------------------ERVY-----STDEI-----QRYILFARQF-QPKITVEAQEFVVDQYKRLRQR----DGGGTTKSAWRITVRQLESMLRLSEGMAR 627

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Match: mcm6l (MCM6 minichromosome maintenance deficient 6, like [Source:ZFIN;Acc:ZDB-GENE-050913-141])

HSP 1 Score: 281.182 bits (718), Expect = 3.634e-81
Identity = 190/588 (32.31%), Postives = 301/588 (51.19%), Query Frame = 1

Query:  496 PNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM--------------TESAS-----TNFHQSSGSGSNCL------FNLVLHVNNIC----RLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDG-------TPITTRQLESMVRLTEAKAR 2145
            P+    V  + F    K   L   +IG+ + + G VV+ + V P  +   F CL C++  I  +   +K+  PT C N VC ++    + +++++  +D+Q +R+QET ++ P                 G IP+++  IL  + V+    GD    TG ++               E++S       F      G   L      + L    N +     R  G +++ +  +  S   + +V++   +  +  + NL+  L  SL P+I+G++ +K  +LL LFGGV K   +    ++RG+ ++ IVGDP   KSQ L+     APR+VY  G + + AGLT +  KD +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISI KAG+   L+ARTS+LAAANP  G YN+AK++ +N+ MSAP++SRFDL +I++D  NEV D  ++R ++ LH      R+  S+                    ER+      S D I     ++YI +A+++  PK++ EA   + + Y  LR+R    DG         IT RQLESM+RL+E  AR
Sbjct:  100 PSKEFYVAFSEFPSRQKIRELSTVRIGTLLRISGQVVRTHPVHPELVSGTFLCLDCQS-VIKDVEQQFKYTQPTICKNPVCANRR-RFMLDTNKSRFVDFQKVRIQETQAELP----------------RGSIPRSVEVILRAEAVETAQAGDRCDFTGTLIVVPDVSAMALAGTRAETSSRVTGKEGFEADGIQGLKALGVRELSYRLAFLANYVAPTNPRFGGKELRQEDQTAESVKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGILLMLFGGVAKTTMEG--TSLRGDINVCIVGDPSTSKSQFLKHVEDFAPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPIDGRYNRAKSLKQNVNMSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHA-----RNVESV--------------------ERVY-----STDEI-----QRYILFARQF-QPKITVEAQEFVVDQYKRLRQR----DGGGTTKSAWRITVRQLESMLRLSEGMAR 627

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Match: pde10a (phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-1013417])

HSP 1 Score: 640.958 bits (1652), Expect = 0.000e+0
Identity = 366/802 (45.64%), Postives = 517/802 (64.46%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS-CLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS-TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            ++  K  + +T+L    PY GW +YF  E Y ++S  + ++ AF  +F+  ++L + + IE K   ++DY DL   E ++  I    +E +   ++I+  M LA+H ++  +             +   + P +   +I+ R+ N+ P+    NL+A+  G +++L+G VV+V+ +KP+C+++ F C  C + Q    PD  K+AVPT+C    C+ +SF   + S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C LI+DLVD+CVPGD V VTGIV   +     +  +   + C+F L +  N++   KG      D   S+ A  +FS+KDLYAI+ I ++ NLF+L+V SLCP+IYGHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ +G   LEAGAL++ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++       +S+         S  S+ +EP      ERL     E  D IP QLLRKY+ YA++YVHP LS +AA +LQ+FYL LRK+   +D TPITTRQLES++RLTEA+AR ELRE A + DA++V ++M  S++G +SDE G L+F RSQ GSGMS  S +KK IS L   +E++ ++ F +  ++QIA    I++ D E  V +LN+QG+LLKKGP  Y+L T
Sbjct:   17 TAPPKPQLTQTTLDKYIPYKGWKLYFS-EAYSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDLLQDEDLSASI-PMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDG-KYAVPTKCPVPECRGRSFTANRSSPLTVTVDWQTIKVQELMSD--------------DQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIVKVSNTRDGMYNKN---NKCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSERPLGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTPITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSNRSKAKKFISALNRIAEQTYNNLFEFQQLRQIAKELQIQVIDFEGFVGSLNDQGYLLKKGPRVYQLQT 797

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Match: pde10a (phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-1013417])

HSP 1 Score: 639.417 bits (1648), Expect = 0.000e+0
Identity = 366/802 (45.64%), Postives = 517/802 (64.46%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS-CLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS-TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            ++  K  + +T+L    PY GW +YF  E Y ++S  + ++ AF  +F+  ++L + + IE K   ++DY DL   E ++  I    +E +   ++I+  M LA+H ++  +             +   + P +   +I+ R+ N+ P+    NL+A+  G +++L+G VV+V+ +KP+C+++ F C  C + Q    PD  K+AVPT+C    C+ +SF   + S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C LI+DLVD+CVPGD V VTGIV   +      ++  +   C+F L +  N++   KG      D   S+ A  +FS+KDLYAI+ I ++ NLF+L+V SLCP+IYGHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ +G   LEAGAL++ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++       +S+         S  S+ +EP      ERL     E  D IP QLLRKY+ YA++YVHP LS +AA +LQ+FYL LRK+   +D TPITTRQLES++RLTEA+AR ELRE A + DA++V ++M  S++G +SDE G L+F RSQ GSGMS  S +KK IS L   +E++ ++ F +  ++QIA    I++ D E  V +LN+QG+LLKKGP  Y+L T
Sbjct:   36 TAPPKPQLTQTTLDKYIPYKGWKLYFS-EAYSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDLLQDEDLSASI-PMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDG-KYAVPTKCPVPECRGRSFTANRSSPLTVTVDWQTIKVQELMSD--------------DQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIVKVSNTRDGGFKNKNN--KCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSERPLGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTPITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSNRSKAKKFISALNRIAEQTYNNLFEFQQLRQIAKELQIQVIDFEGFVGSLNDQGYLLKKGPRVYQLQT 817

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Match: pde10a (phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-1013417])

HSP 1 Score: 637.876 bits (1644), Expect = 0.000e+0
Identity = 367/806 (45.53%), Postives = 521/806 (64.64%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS-CLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTE----QSLNRSSSSIRQMDTMSFHSMTKEP-GSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            ++  K  + +T+L    PY GW +YF  E Y ++S  + ++ AF  +F+  ++L + + IE K   ++DY DL   E ++  I    +E +   ++I+  M LA+H ++  +             +   + P +   +I+ R+ N+ P+    NL+A+  G +++L+G VV+V+ +KP+C+++ F C  C + Q    PD  K+AVPT+C    C+ +SF   + S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C LI+DLVD+CVPGD V VTGIV  + ++T         + C+F L +  N++   KG      D   S+ A  +FS+KDLYAI+ I ++ NLF+L+V SLCP+IYGHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ +G   LEAGAL++ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++       QS + +  + +  +T      ++ P G     RL  G  E  D IP QLLRKY+ YA++YVHP LS +AA +LQ+FYL LRK+   +D TPITTRQLES++RLTEA+AR ELRE A + DA++V ++M  S++G +SDE G L+F RSQ GSGMS  S +KK IS L   +E++ ++ F +  ++QIA    I++ D E  V +LN+QG+LLKKGP  Y+L T
Sbjct:   44 TAPPKPQLTQTTLDKYIPYKGWKLYFS-EAYSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDLLQDEDLSASI-PMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDG-KYAVPTKCPVPECRGRSFTANRSSPLTVTVDWQTIKVQELMSD--------------DQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIV--KVSNTRDGGFKNKNNKCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSERPLGERLKVRLRPG--EHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTPITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSNRSKAKKFISALNRIAEQTYNNLFEFQQLRQIAKELQIQVIDFEGFVGSLNDQGYLLKKGPRVYQLQT 827

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Match: pde10a (phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-1013417])

HSP 1 Score: 620.157 bits (1598), Expect = 0.000e+0
Identity = 355/775 (45.81%), Postives = 503/775 (64.90%), Query Frame = 1

Query:  226 YMETSQTVMRIEAFSSYFS-CLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTE----QSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            Y ++S  + ++ AF  +F+  ++L + + IE K   ++DY DL   E ++  I    +E +   ++I+  M LA+H ++  +             +   + P +   +I+ R+ N+ P+    NL+A+  G +++L+G VV+V+ +KP+C+++ F C  C + Q    PD  K+AVPT+C    C+ +SF   + S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C LI+DLVD+CVPGD V VTGIV   +      ++  +   C+F L +  N++   KG      D   S+ A  +FS+KDLYAI+ I ++ NLF+L+V SLCP+IYGHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ +G   LEAGAL++ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++       QS + +  + +  +T      ++ P     ERL     E  D IP QLLRKY+ YA++YVHP LS +AA +LQ+FYL LRK+   +D TPITTRQLES++RLTEA+AR ELRE A + DA++V ++M  S++G +SDE G L+F RSQ GSGMS  S +KK IS L   +E++ ++ F +  ++QIA    I++ D E  V +LN+QG+LLKKGP  Y+L T
Sbjct:   47 YSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDLLQDEDLSASI-PMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDG-KYAVPTKCPVPECRGRSFTANRSSPLTVTVDWQTIKVQELMSD--------------DQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIVKVSNTRDGGFKNKNN--KCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENLFQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSERP---LGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTPITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSNRSKAKKFISALNRIAEQTYNNLFEFQQLRQIAKELQIQVIDFEGFVGSLNDQGYLLKKGPRVYQLQT 799

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Match: pde10a (phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-1013417])

HSP 1 Score: 610.912 bits (1574), Expect = 0.000e+0
Identity = 358/802 (44.64%), Postives = 509/802 (63.47%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS-CLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS-TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            ++  K  + +T+L    PY GW +YF  E Y ++S  + ++ AF  +F+  ++L + + IE K   ++DY DL   E ++  I    +E +   ++I+  M LA+H ++  +             +   + P +   +I+ R+ N+ P+    NL+A+  G +++L+G VV+V+ +KP+C+++ F C  C + Q    PD  K+AVPT+C    C+ +SF   + S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C LI+DLVD+CVPGD V VTGIV   +      ++  +   C+F L +  N++   KG      D   S+ A  +FS+KDLYAI+ I ++ NLF+L+V       Y  +LVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ +G   LEAGAL++ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++       +S+         S  S+ +EP      ERL     E  D IP QLLRKY+ YA++YVHP LS +AA +LQ+FYL LRK+   +D TPITTRQLES++RLTEA+AR ELRE A + DA++V ++M  S++G +SDE G L+F RSQ GSGMS  S +KK IS L   +E++ ++ F +  ++QIA    I++ D E  V +LN+QG+LLKKGP  Y+L T
Sbjct:   49 TAPPKPQLTQTTLDKYIPYKGWKLYFS-EAYSDSSPFLEKVRAFEKFFTKQIELYDKDEIERKGSILVDYKDLLQDEDLSASI-PMSSELKEMPEKILECMGLAIHQVLTKDLERHAAELQEQEGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYGKYVALRGTVVRVSNIKPLCVKMAFSCNMCGDIQSFPFPDG-KYAVPTKCPVPECRGRSFTANRSSPLTVTVDWQTIKVQELMSD--------------DQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIVKVSNTRDGGFKNKNN--KCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENLFQLIVNDKI--FYVVQLVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGAKEMQSADLTCPTTQNSNTSVLEEPSERPLGERLKLRPGEHFDPIPHQLLRKYVGYARQYVHPTLSPDAAQVLQDFYLELRKQNQGIDSTPITTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRSQHGSGMSNRSKAKKFISALNRIAEQTYNNLFEFQQLRQIAKELQIQVIDFEGFVGSLNDQGYLLKKGPRVYQLQT 828

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Match: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:MGI Symbol;Acc:MGI:1913884])

HSP 1 Score: 672.159 bits (1733), Expect = 0.000e+0
Identity = 372/800 (46.50%), Postives = 520/800 (65.00%), Query Frame = 1

Query:  163 KTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNS-----DLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +++L    PY GW +YF  E Y   S  + +I+AF  +F+   ++L   + IE K   ++D+ +L  ++ IT +I + +N  +   ++ +  M LA+H ++  +             +SN      ++P+IY   R+ N+ P+    N++A   G +IS++G VV+V+ +KP+C  + F+C  C   Q   LPD  K+ +PT+C    C+ +SF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V VTGIV     S +   S      C+F L +  N++   KG      +    +    EFS+KDLYAI  I +E NL KL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ H+LIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKA+TV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ ++     +T     ++++P     ERL     E  D IP QLLRKYI YA++YVHP+LS++AA  LQ+FYL LRK+   +  +PITTRQLES++RLTEA+AR ELRE A  +DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F Y  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   59 QSTLDQFIPYKGWKLYFS-EVYSNNSPFIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNGGETMVNVPHIY--ARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDG-KYTLPTKCPVPACRGRSFAPLRSSPLTVTLDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIV---KVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKP---LSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 832

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Match: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:MGI Symbol;Acc:MGI:1913884])

HSP 1 Score: 657.907 bits (1696), Expect = 0.000e+0
Identity = 364/779 (46.73%), Postives = 508/779 (65.21%), Query Frame = 1

Query:  226 YMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNS-----DLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            Y   S  + +I+AF  +F+   ++L   + IE K   ++D+ +L  ++ IT +I + +N  +   ++ +  M LA+H ++  +             +SN      ++P+IY   R+ N+ P+    N++A   G +IS++G VV+V+ +KP+C  + F+C  C   Q   LPD  K+ +PT+C    C+ +SF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V VTGIV     S +   S      C+F L +  N++   KG      +    +    EFS+KDLYAI  I +E NL KL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ H+LIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKA+TV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ ++     +T     ++++P     ERL     E  D IP QLLRKYI YA++YVHP+LS++AA  LQ+FYL LRK+   +  +PITTRQLES++RLTEA+AR ELRE A  +DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F Y  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   51 YSNNSPFIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNGGETMVNVPHIY--ARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDG-KYTLPTKCPVPACRGRSFAPLRSSPLTVTLDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIV---KVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKP---LSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 804

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Match: Mcm2 (minichromosome maintenance complex component 2 [Source:MGI Symbol;Acc:MGI:105380])

HSP 1 Score: 290.426 bits (742), Expect = 6.766e-84
Identity = 210/642 (32.71%), Postives = 328/642 (51.09%), Query Frame = 1

Query:  310 EIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLP---DDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC-LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            E ++  +++Y DL + E+   V+  F  E      +I  E  L +  L        I+N      +I+VRI++   + +  +L+   +   I   G V     V P    VK+ C  C     V+ P      +   P  C    C+S    P +   +ET+  +YQ IR+QE+                  K   GR+P++ + IL+ DLVD+C PGDE+ +TGI        N+  S  + +   +F  ++  N++   K D K+ V        E + +D+  I  +  +  + + + AS+ PSIYGHE +K  L LALFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    ++ R+++  G   +  GLT    +   S    LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H      R   S ++ + ++ +  T EP        +YG     + +P ++L+KYI YAK+ V PKL+    + +   Y  LRK        PIT R +ESM+R+ EA AR  LR+   E D      +M+ES +
Sbjct:  225 ENRESLVVNYEDLAAREH---VLAYFLPEAPAELLQIFDEAALEV-VLAMYPKYDRITN------HIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKC---NFVLGPFCQSQNQEVKPGSCPE--CQSAG--PFEINMEETIYQNYQRIRIQESPG----------------KVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIY-----HNNYDGSLNTANGFPVFATIILANHVA--KKDNKVAV-------GELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKV--RGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHV-----RHHPSNKKDEGLT-NGGTLEPAMPN----TYG----VEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFI 803

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Match: Mcm6 (minichromosome maintenance complex component 6 [Source:MGI Symbol;Acc:MGI:1298227])

HSP 1 Score: 287.73 bits (735), Expect = 9.312e-84
Identity = 211/678 (31.12%), Postives = 339/678 (50.00%), Query Frame = 1

Query:  385 FKNEFQFNCQ----------RIILEMCLALHTLV-------FANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKS-KSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMT-----------ESASTNFHQSSGSG-----------------SNCLFNLVLHVNNI-CRLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT--EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTP-------ITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGI 2244
            F +  QFN Q          R+   +C AL T V       FA +   ++  DLP  +            K   L +++IG    + G VV+ + V P  +   F CL C+   I  +   +K+  P  C N VC + K F  L +++++  +D+Q +R+QET ++ P                 G IP++L  IL  + V++   GD    TG ++              A TN   S   G                 S  L  L  HV     R  G +++ +  +  S   + +VK+   +  +  + NL+  L  SL P+I+G++ VK  +LL LFGGV K   +    ++RG+ ++ IVGDP   KSQ L+     +PR+VY  G + + AGLT +  +D +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISI KAG+   L+ARTS+LAAANP +GHY+++K++ +N+ +SAP++SRFDL +I++D  NEV D  ++R ++ LH+  E+S++R                                  S D+I     R+Y+ +A+++  PK+S E+ + + E Y  LR+R    DG+        IT RQLESM+RL+E+ AR    +    +  K+   L+ +S++ V + ++ +
Sbjct:   65 FADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFY-VAFQDLPTRH------------KIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQT-VIKDVEQQFKYTQPNICRNPVCANRKRF--LLDTNKSRFVDFQKVRIQETQAELP----------------RGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGT--SLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVY--------------------------------SLDDI-----RRYLLFARQF-KPKISKESEDFIVEQYKRLRQR----DGSGVTKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNL 666

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Match: Mcm6 (minichromosome maintenance complex component 6 [Source:MGI Symbol;Acc:MGI:1298227])

HSP 1 Score: 287.73 bits (735), Expect = 1.505e-83
Identity = 207/645 (32.09%), Postives = 324/645 (50.23%), Query Frame = 1

Query:  385 FKNEFQFNCQ----------RIILEMCLALHTLV-------FANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKS-KSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMT-----------ESASTNFHQSSGSG-----------------SNCLFNLVLHVNNI-CRLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT--EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTP-------ITTRQLESMVRLTEAKAR 2145
            F +  QFN Q          R+   +C AL T V       FA +   ++  DLP  +            K   L +++IG    + G VV+ + V P  +   F CL C+   I  +   +K+  P  C N VC + K F  L +++++  +D+Q +R+QET ++ P                 G IP++L  IL  + V++   GD    TG ++              A TN   S   G                 S  L  L  HV     R  G +++ +  +  S   + +VK+   +  +  + NL+  L  SL P+I+G++ VK  +LL LFGGV K   +    ++RG+ ++ IVGDP   KSQ L+     +PR+VY  G + + AGLT +  +D +S    +EAGAL+++DNG CCIDEFDKM  +   ++ EAMEQQ+ISI KAG+   L+ARTS+LAAANP +GHY+++K++ +N+ +SAP++SRFDL +I++D  NEV D  ++R ++ LH+  E+S++R                                  S D+I     R+Y+ +A+++  PK+S E+ + + E Y  LR+R    DG+        IT RQLESM+RL+E+ AR
Sbjct:   65 FADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFY-VAFQDLPTRH------------KIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQT-VIKDVEQQFKYTQPNICRNPVCANRKRF--LLDTNKSRFVDFQKVRIQETQAELP----------------RGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGT--SLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVY--------------------------------SLDDI-----RRYLLFARQF-KPKISKESEDFIVEQYKRLRQR----DGSGVTKSSWRITVRQLESMIRLSESMAR 633

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BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Match: sp|D3ZVK1|MCM8_RAT (DNA helicase MCM8 OS=Rattus norvegicus OX=10116 GN=Mcm8 PE=3 SV=1)

HSP 1 Score: 672.159 bits (1733), Expect = 0.000e+0
Identity = 372/802 (46.38%), Postives = 520/802 (64.84%), Query Frame = 1

Query:  163 KTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV----------------FANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +++L    PY GW +YF  E Y   S    +I+AF  +F+   ++L   + IE K   ++D+ +L     IT +I + +N  +   ++ +  M LA+H ++                  N   ++ N  +P+IY   R+ N+ P+    N++A   G +IS++G VV+V+ +KP+C ++ F+C  C   Q   LPD  K+ +PT+C    C+ +SF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V VTGIV     S +   S      C+F L +  N++   KG      +    +    EFS+KDLYAI+ I +E NL KL+V SLCP I+GHELVKA L+LALFGG  K+ +DKNR+ IRG+ H+LIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKA+TV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ ++     +T     ++++P     ERL     E  D IP QLLRKYI YA++YVHP+LS+EAA  LQ+FYL LRK+   +  +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   56 QSTLDQFIPYKGWKLYFS-EVYSNNSPLTEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTKDNEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLCNGGGTMVN--VPHIY--ARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTKMAFQCAACGEIQSFPLPDG-KYNLPTKCPVPACRGRSFTPLRSSPLTVTMDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIV---KVSNSEEGSRSKNDKCMFLLYIEANSVSNSKGQKAQTAEDGCKHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLMLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTATSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVSRVLSQDSNTSVLEVVSEKP---LSERLKVAPGEKTDPIPHQLLRKYIGYARQYVHPRLSTEAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 829

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BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Match: sp|Q9CWV1|MCM8_MOUSE (DNA helicase MCM8 OS=Mus musculus OX=10090 GN=Mcm8 PE=1 SV=3)

HSP 1 Score: 672.159 bits (1733), Expect = 0.000e+0
Identity = 372/800 (46.50%), Postives = 520/800 (65.00%), Query Frame = 1

Query:  163 KTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN---------NISSISNS-----DLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +++L    PY GW +YF  E Y   S  + +I+AF  +F+   ++L   + IE K   ++D+ +L  ++ IT +I + +N  +   ++ +  M LA+H ++  +             +SN      ++P+IY   R+ N+ P+    N++A   G +IS++G VV+V+ +KP+C  + F+C  C   Q   LPD  K+ +PT+C    C+ +SF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V VTGIV     S +   S      C+F L +  N++   KG      +    +    EFS+KDLYAI  I +E NL KL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ H+LIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKA+TV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ ++     +T     ++++P     ERL     E  D IP QLLRKYI YA++YVHP+LS++AA  LQ+FYL LRK+   +  +PITTRQLES++RLTEA+AR ELRE A  +DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F Y  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   59 QSTLDQFIPYKGWKLYFS-EVYSNNSPFIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNGGETMVNVPHIY--ARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDG-KYTLPTKCPVPACRGRSFAPLRSSPLTVTLDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIV---KVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKP---LSERLKVAPGEQTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQSQRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 832

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BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Match: sp|Q9UJA3|MCM8_HUMAN (DNA helicase MCM8 OS=Homo sapiens OX=9606 GN=MCM8 PE=1 SV=2)

HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0
Identity = 378/803 (47.07%), Postives = 531/803 (66.13%), Query Frame = 1

Query:  139 STKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGD-VKMDVDS-ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            STK    ++++L    PY GW +YF  E Y ++S  + +I+AF  +F+   ++L   + IE K   ++D+ +L     +T +I +   E +   ++ +  M LA+H ++  +             +S+   + +   +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C  C   Q   LPD  K+++PT+C   VC+ +SF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TGIV   +A      S      C+F L +  N+I   KG   K   D  ++    EFS+KDLYAI+ I +E NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+AC +APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI YA++YV+P+LS+EAA +LQ+FYL LRK+   ++ +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   58 STKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFT-RHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDG-KYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEG---SRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 839

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BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Match: sp|I0IUP3|MCM8_CHICK (DNA helicase MCM8 OS=Gallus gallus OX=9031 GN=MCM8 PE=1 SV=1)

HSP 1 Score: 664.455 bits (1713), Expect = 0.000e+0
Identity = 366/795 (46.04%), Postives = 516/795 (64.91%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV---FANNISSIS-NSDLP-------NI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +++++L    PY GW +YF  E Y + S  V + +AF  +F   ++ L   + IE K   ++DY +L     +TK I     E +   Q+I+  M LA+H ++      + + +     LP       N+  I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+ +KP+C ++ F C TC + Q V LPD  K+ +PT+C+   C+ +SF P + S  T T+D+Q +++QE  SD              D+   GRIP+T+ C L++DLVD+CVPGD V +TG+V    +ST    S      C+F L +  N++   KG    + + E    +  EFS+KDLYA++ I +E NLF+++V SLCP+IYGHE+VKA L LALFGG  KF +DKNR+ +RG+ H+LIVGDPGLGKSQMLQ+ C +APR VY+CG + T++GLTV+ S+D  SG  ALEAGALV+ D G C IDEFDKM + QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+ + + +      +         ERL     E+ D IP QLLRKY+ YA++YVHP LS EAA +LQEFYL LRK+      TPITTRQLES++RLTEA++R ELRE   ++DA+DV E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ +S L + +ER+ S+ F+   ++Q+A    I++ D E+ + +LN+QG+LLKKG   Y+L T
Sbjct:   55 LVQSTLDQFIPYKGWKLYFS-EAYADKSPFVQKTQAFEKFF-MQRIELYDKDEIERKGSILVDYKELIEDRELTKSIPNISTELRDMPQKILQCMGLAIHQVLTKDLERHAAELQVQEGLPLDGEPIINVPLIHARLYNYEPLTQLKNVRANCYGKYIALRGTVVRVSNIKPLCTKLAFVCGTCGDVQSVPLPDG-KYTLPTKCLVPECRGRSFTPDRSSPLTATVDWQSVKVQELMSD--------------DQREAGRIPRTIECELVQDLVDSCVPGDVVTITGVVKV--SSTEEGASKNKNDKCVFLLYIEANSVSNSKGQKTKNFEEETFQRSFMEFSLKDLYAVQEIQAEENLFRIIVNSLCPAIYGHEIVKAGLALALFGGCQKFVDDKNRIPVRGDPHVLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTSTSSGLTVTLSRDGASGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSISLAKAGIVCSLPARTSIVAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAIRAGKQAVCSSAVVSRTNVQDRSVLEVVSDRPLLERLKISPGENFDAIPHQLLRKYVGYARQYVHPHLSPEAAQVLQEFYLELRKQNQGASSTPITTRQLESLIRLTEARSRLELREKCTKEDAEDVIEIMKYSMLGTYSDEFGKLDFERSQHGSGMSNRSQAKRFVSALSSIAERTYSNLFDLQQLRQVAKELQIRVFDFESFIESLNDQGYLLKKGSRLYQLQT 829

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BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Match: sp|E1BPX4|MCM8_BOVIN (DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=2)

HSP 1 Score: 653.284 bits (1684), Expect = 0.000e+0
Identity = 375/797 (47.05%), Postives = 521/797 (65.37%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVF-----------ANNISSISNSDLPNI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +L+++L    PY GW +YF  E Y ++   + +IEAF S+F+  ++ L   + IE K   ++D+ +L + + I K+I    NE +   ++ +  M LA+H ++            A    S +   + N+ +I+ R+ N+ P+ +  N++AN  G +I+L+G VV+V+  KP+C ++ F C  C   Q + LPD  K+ +PT+C    C+ KSF  L+ S  TVT+D+Q I++QE  SD              D+   GRIP+T+ C L+ DLVD+CVPGD V +TG+V   +A                      N++   KG      +    + A  EFS+KDLYAI+ I SE NLFKL+V SLCP I+GHELVKA L LALFGG  K+ +DKNR+ IRG+ H+L+VGDPGLGKSQMLQ+ C++APR VY+CG + TT+GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAGMVC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +M++   ++   E  S     ERL     E+ D IP QLLRKYI Y+++YV+P+LS+EAA ILQ FYL LRK+   +  +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  SA+K+ IS L   +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   56 LLQSTLDHFIPYKGWKLYFS-EVYSDSIPFIEKIEAFESFFT-ERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDG-KYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSD--------------DQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAE-------------------EANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQT 815

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BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Match: A0A1S3JYB5 (DNA helicase MCM8 OS=Lingula unguis OX=7574 GN=LOC106177222 PE=3 SV=1)

HSP 1 Score: 728.398 bits (1879), Expect = 0.000e+0
Identity = 392/788 (49.75%), Postives = 519/788 (65.86%), Query Frame = 1

Query:  187 PYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLK--LNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSD-----LPNI-------YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSN---CLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLTAGF 2496
            PY GW  YFP E Y   S TV R++ F  YF   K   N E IE K H  +D+ +LC    I   + +     +   ++++  + LALH  V ++ +      D     LP +        I+ RI N  PI +  NL+A+  G F+S+KG VV+V+ +KP+C ++ F C +C+  Q V+LPD  K+ VPT+CVN  CK+++F PL+ S  T TID+Q IR+QE  +D              D  + GRIP+T++C L  DLVD+CVPGD V V+GIV   S         G G N   C+F L LH N++   KG        E     +F++K+LYAIE I SE  LF+L+V SLCPSIYGHE+VKA L+L LFGG  K+ NDKNR+ +RG+ HIL+VGDPGLGKSQMLQ+   +APRSVY+CG + T++GLTV+ SK+  SG  ALEAGALV++D GCCCIDEFDKM + QH +LLEAMEQQSISIAKAG+VC+L ARTS+LAAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD+P+E +DS LS HV+++H  +      ++ R+    +      E      ER+     E+ D IPPQLLRKY+ YA+KYVHPK++ EAA ++Q+FYL LRK+    D TPITTRQLES++RLTEA+AR ELRE A E DAKDV ++M  SM+  YS+ELG L+F RSQ GSGMS  +  K+LI+ LQ  SE + +S F   +++QIA +A I++ D E+ +++LN QGFLLKKGP  Y+L TAGF
Sbjct:   94 PYKGWRFYFPEEAYSPHSPTVTRVQVFEKYFINWKALYNAENIESKGHFTVDFKELCQDPVIQDGLSDLAALLKEMPEQMVNAIGLALHQ-VLSSGLEQDVQGDSEDPFLPPLSAPYSLPVIHARILNHEPITQLKNLKAHYYGKFVSVKGTVVRVSNIKPLCTKMAFECNSCRTVQSVILPDG-KYVVPTKCVNTNCKARTFIPLRSSHLTETIDWQTIRVQEIITD--------------DMRDSGRIPRTVDCELTNDLVDSCVPGDIVTVSGIVKVTSTE------KGRGRNKDKCMFLLYLHANSVNNSKG--PKSGAGEQGLAIDFTLKELYAIEEIQSEKKLFRLIVGSLCPSIYGHEMVKAGLVLGLFGGSQKYANDKNRIPVRGDPHILVVGDPGLGKSQMLQAVAGVAPRSVYVCGNTTTSSGLTVTLSKEGGSGDYALEAGALVLADQGCCCIDEFDKMGS-QHQALLEAMEQQSISIAKAGIVCSLPARTSILAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDKPDEEMDSMLSEHVMAMHAGKKRILQGTTARRNQEQNEAYSEWEADKPLSERIKVPRGENLDVIPPQLLRKYVGYARKYVHPKITKEAAKVIQQFYLDLRKQHQSRDSTPITTRQLESLIRLTEARARLELREEATEHDAKDVVDIMKFSMIDTYSNELGFLDFERSQHGSGMSSKAQGKRLIAALQKMSETTYNSLFTVQEMRQIAQSAGIQVRDFEDFISSLNNQGFLLKKGPRVYQLQTAGF 856

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BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Match: A0A0L8GIE4 (MCM domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22033113mg PE=3 SV=1)

HSP 1 Score: 689.493 bits (1778), Expect = 0.000e+0
Identity = 376/782 (48.08%), Postives = 513/782 (65.60%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLK--LNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN----NISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKL 2481
            +++  L    PY GW++YFP E Y   S TV +++ F  YFS  +   NL  IE ++H  + + ++ S   IT    +F  E + + ++II  + LA+H L+       + SS ++S LP IY   RI     I +  N++AN  G F+++KG VV+V  VKP+CI+++F C +C N +I++LPD  K+  P +C +  C+S+ F P + S +T +ID+Q IRLQE               +  D+   GRIP+T+ C L  DLVD+CVPGD V + GIV     +T+    S +   CLF L +  N++   KG              +F++K+LYAI+ IHSE +LF+LLV SLC SI GHE+VKA L+L LFGG  +F NDK+ VAIRG+ HIL+VGDPGLGKSQMLQ+   +APRSVY+CG S T +GLTV+  K+  S   ALEAGALV++D GCCCIDEFDKM   QH +LLEAMEQQSISIAKAG+VC+L AR S++AAANP  GHY+KA+TV+ENLKM   LLSRFDLV+I+LD+P+EV D+ LS HV+++H  +    S    +  DT SF  ++     T  ERL+    E  D IPPQL RKY+ YA+KYVHPK+  EAA++LQ+FYL LR++ H  D TPITTRQLES++RLTEA+AR+ELRE A ++DA+DV  +M  SM   YSDE G+L+F RSQ GSGMS  S  KK I+LLQ  +E++ +S F   ++K++A   N ++ D E  + +LN  G+LLKKGP  Y+L
Sbjct:   70 LVQNKLAFASPYKGWILYFPEEAYTAESPTVEKLKVFEEYFSKYEQLYNLYDIETQRHFYVSFAEMASDNIITTRFPDFPKELRDSPEKIIKCLGLAMHQLILTKRKEEHDSSETDSYLPMIY--ARIKECDNIVQLKNIKANYYGKFVTVKGTVVRVGNVKPLCIKMEFECNSCSNLEIILLPDG-KYVTPQKCTSSGCRSRVFHPKQSSPKTESIDWQTIRLQE---------------VMGDQNETGRIPRTIECDLTNDLVDSCVPGDTVSIAGIV---KVNTSNEGHSRNKDKCLFLLYIQANSVTNPKGKT---TGESAGLAMDFTMKELYAIQEIHSEKHLFRLLVGSLCSSICGHEMVKAGLVLGLFGGTQRFANDKDCVAIRGDPHILMVGDPGLGKSQMLQAVSNVAPRSVYVCGNSTTVSGLTVTLCKETGSNDHALEAGALVLADQGCCCIDEFDKMK-HQHQALLEAMEQQSISIAKAGIVCSLPARASIIAAANPIGGHYSKARTVSENLKMGNALLSRFDLVFILLDKPDEVKDNMLSSHVMAMHAGKKWKVSPFFTKSQDT-SFEDLS---NMTLQERLTIHPYEKIDLIPPQLFRKYVGYARKYVHPKIGKEAASVLQKFYLDLRRQHHSRDSTPITTRQLESLIRLTEARARAELREEATKEDAEDVITIMKYSMKETYSDEFGMLDFRRSQHGSGMSSRSQHKKFITLLQRKAEKTYNSIFTVQEMKELAKELNFQMIDFEGFLTSLNNHGYLLKKGPKVYQL 822

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BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Match: A0A3B3T3T5 (Minichromosome maintenance 8 homologous recombination repair factor OS=Paramormyrops kingsleyae OX=1676925 PE=3 SV=1)

HSP 1 Score: 686.411 bits (1770), Expect = 0.000e+0
Identity = 385/811 (47.47%), Postives = 531/811 (65.47%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN----NISSISNSDLP-------NI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSN----CLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMS-----FHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
              +++  + +T+L+  C Y GW +YF  E +ME+S  V +I+AF  YFS  ++ L   + IE K   ++DY DL   E ++        EF+   ++++  + LA+H ++  +     +       LP       NI YIN R+ NF P+     L+AN  G +++L+G VV+V+ +KP+C ++ F C  C + Q   LPD  KFA PT+C+   C+S+SF P + S  T+T+DYQ I++QE  SD              D+   GRIP+T+ C L +DLVD+ VPGD V +TG+V   S         G G N    C+F L L  N+I   KG    +     S  A  EFS+KDLYAI+ I ++ +L KL+V SLCP+IYGH LVKA L+LALFGG  K+ +DKNR+ IRG+ HIL+VGDPGLGKSQMLQ+ C +APR VY+CG + TT+GLTV+ S+D+ SG  ALEAGALV+SD G CCIDEFDKM + QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  +S HV+++ + +++ R+ +++   DT         ++  +P S   E L  G +ES D IP QLLRKYI YA+ YVHPKLS+EAA +LQ+FYL LR++    D TPITTRQLES++RLTEA+AR ELRE+A + DA+DV E+M  S++  YSDE G ++F RSQ GSGMS  S  KK ++ L   +ER+  + F Y  ++Q+A+  NI+++D E  ++ LNEQG+LLKKGP +Y+L T
Sbjct:   83 GGSQQPQMSQTTLIEKCHYKGWRLYFS-EAFMESSPYVQKIQAFERYFSS-RIELYDKDEIERKGSILVDYKDLIQDEQLSLAQPTLATEFKDMPEKLLDCLGLAIHQVLTMDLERHAVELQGQEGLPSGTAAVVNIPYINARVYNFEPLTPLKMLKANLYGKYVALRGTVVRVSNIKPLCAKMAFVCNNCGDTQSFHLPDG-KFATPTKCLQPGCRSRSFTPNRSSPLTLTVDYQTIKVQELISD--------------DQREAGRIPRTIECELTQDLVDSSVPGDTVTITGVVKVSS-------EEGYGRNKKDRCMFLLFLKANSISNSKGQKSKEEAEPESQGALVEFSLKDLYAIQEIQAQGDLLKLIVHSLCPTIYGHLLVKAGLVLALFGGCQKYMDDKNRIPIRGDPHILVVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVTLSRDSASGDYALEAGALVLSDQGICCIDEFDKMGS-QHQALLEAMEQQSISLAKAGIVCSLPARTSIVAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDYDHMVSDHVIAMRSGKTVVRAGATVSHTDTRESEISILEAVGDKPIS---ESLKVGPRESLDLIPHQLLRKYIGYARHYVHPKLSAEAAQVLQDFYLELRRQNQSADSTPITTRQLESLIRLTEARARLELREVATKSDAEDVVEIMKHSLLDTYSDEFGRIDFDRSQLGSGMSNRSQKKKFVAALNRMAERTYKTVFEYQQLRQLAMELNIQVADFEGFISGLNEQGYLLKKGPKTYQLQT 865

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BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Match: G3GSC8 (DNA replication licensing factor MCM8 OS=Cricetulus griseus OX=10029 GN=I79_000451 PE=3 SV=1)

HSP 1 Score: 685.256 bits (1767), Expect = 0.000e+0
Identity = 378/804 (47.01%), Postives = 527/804 (65.55%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS--CLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFAN------------NISSISNS--DLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM---TESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDS--ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +L+++L    PY GW +YF  E Y  +S  + +I+AF  +F+      + + IE K   ++D+ +L   + IT +I + +N  +   ++ +  M LA+H ++  +             +SS   +  ++P+I+   R+ N+ P+    N++AN  G +IS++G VV+V  +KP+C ++ FRC  C   Q   LPD  K+ +PT+C    C+ KSF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V +TGIV    TE  S N          C+F L +  N++   KG      +   ++    EFS+KDLYAI+ I +E NL KL+V SLCP I+GHELVKA L+LALFGG  K+ +DKNR+ IRG+ HILIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +      +T     ++++P     ERL     E+ D IP QLLRKY+ YA++YVHPKLS+EAA  LQ+FYL LRK+   M  +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   57 LLQSTLDQFIPYKGWKLYFS-EVYSNSSPFIEKIQAFEKFFTRHIDFYDKDEIERKGSILVDFKELTKDDEITNLIPDIENTLRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSSDGETMVNVPHIF--ARVYNYEPLTHLKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAACGEIQSFPLPDG-KYNLPTKCPVPACRGKSFTPLRSSPLTVTVDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRN------KNDKCMFLLYIEANSVSNSKGQKAQTAEDGCQHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVARALSQDSNTSVLEVVSEKP---LSERLKVAPGETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 832

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BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Match: A0A1U7QLN4 (DNA helicase MCM8 isoform X1 OS=Mesocricetus auratus OX=10036 GN=Mcm8 PE=3 SV=1)

HSP 1 Score: 685.256 bits (1767), Expect = 0.000e+0
Identity = 377/806 (46.77%), Postives = 527/806 (65.38%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFS--CLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV----------------FANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM---TESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDS--ENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQM-----DTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            +L+++L    PY GW +YF  E Y  +S  + + +AF  +F+      + + IE K   ++D+ +L   + IT +I + +N  +   ++ +  M LA+H ++                 +N+  ++ N  +P+I+   R+ N+ P+    N++AN  G +IS++G VV+V  +KP+C ++ FRC  C   Q + LPD  K+ +PT+C    C+ KSF PL+ S  TVT+D+Q+I++QE  SD               +   GRIP+T+ C L+ DLVD+CVPGD V +TGIV    TE  S N          C+F L +  N++   KG      +   ++    EFS+KDLYAI+ I +E NL KL+V SLCP I+GHELVKA L+LALFGG  K+ +DKNR+ IRG+ HILIVGDPGLGKSQMLQ+AC +APR VY+CG + T++GLTV+ SKD+ SG  ALEAGALV+ D G C IDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNKAKTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS HV+++   +    SS+++ +      +T     ++++P     ERL     E+ D IP QLLRKY+ YA++YVHPKLS+EAA  LQ+FYL LRK+   M  +PITTRQLES++RLTEA+AR ELRE A ++DA+D+ E+M  SM+G YSDE G L+F RSQ GSGMS  S +K+ IS L + +ER+ ++ F +  ++QIA   NI+++D EN + +LN+QG+LLKKGP  Y+L T
Sbjct:   57 LLQSTLDQFIPYKGWKLYFS-EVYSNSSPFIEKTQAFEKFFTRHIDFYDKDEIERKGSILVDFKELTKDDEITDLIPDIENALRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVN--VPHIF--ARVYNYEPLTHLKNVRANCYGKYISIRGTVVRVGNIKPLCTKMAFRCAACGEIQSIPLPDG-KYNLPTKCPVSACRGKSFAPLRSSPLTVTVDWQLIKIQELMSDA--------------QREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNTEEGSRN------KNDKCMFLLYIEANSVSNSKGQKAQTAEDGCQHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLVLALFGGSQKYADDKNRIPIRGDPHILIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKM-GNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVARALSQDSNTSVLEVVSEKP---LSERLKVAPGETTDPIPHQLLRKYVGYARQYVHPKLSTEAAQALQDFYLELRKQSQRMSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQT 832

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:NCBI gene;Acc:103047810])

HSP 1 Score: 654.825 bits (1688), Expect = 0.000e+0
Identity = 363/803 (45.21%), Postives = 513/803 (63.89%), Query Frame = 1

Query:  157 ILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV------FANNIS---SISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSN----CLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSI----RQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            + + +L   CPY GW +YF  E ++E++  V +I+ F  YF+  +++L   + IE K   ++DY DL  ++ I+  + +   E +    +I+  + LA+H ++       A+ +     +     P I   +I+ RI N+ P+     L+AN  G F++++G VV+V+ +KP+C ++ F C +C + Q + LPD  K+  P++C  + C+ + F P + S  T+T+D+Q I++QE  SD              D+   GRIP+T+ C L +DLVD+CVPGD V +TGI+   +         GSG N    C+F L ++ N++   KG          S  A  EFS+KDLY I+ I ++ +LFKL+V SLCP+IYGH LVKA L LALFGG  K+ +DKNR+ IRG+ H+L+VGDPGLGKSQMLQ+ C ++PR +Y+CG + T++GLTVS S+D+ SG  ALEAGALV+ D G CCIDEFDKM   QH +LLEAMEQQSIS+AKAG+VC L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS H++++   +    SS+++     Q   +S   ++ +      +RL     E+ D IP QLLRKY+ YA+ YVHP LS+EAA +LQ+FYL LRK+    D TPITTRQLES++RLTEA+AR ELRE A E DA+DV ++M  S+   YSDE G L+F RSQ GSGMS  S  KK +  L   +ERS  + F+ P+++Q+A    I++ D E  ++ LNEQG+LLKKG   Y+L T
Sbjct:  112 VTQATLDITCPYKGWRLYFS-EGFVESTPYVEKIKTFEQYFTS-QIDLYDKDEIERKGSILVDYKDLLLNKQISAALPDLARELRDMPDKILDCLGLAIHQVLTKDLERHADELQVQEGLPTEATPIINIPHISARIYNYEPLTPLKMLRANIYGKFVAIRGTVVRVSNIKPLCSKMAFICNSCGDTQSLDLPDG-KYTTPSKCPQKECRGRIFTPNRSSPLTLTVDWQTIKVQELISD--------------DQRESGRIPRTIECELTQDLVDSCVPGDMVTITGIIKVSN-------EEGSGRNKKDKCMFLLYINANSVSNSKGQKSKSASEPESQGASVEFSLKDLYGIQEIQAQEDLFKLIVNSLCPAIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCNVSPRGIYVCGNTTTSSGLTVSLSRDSGSGDYALEAGALVLGDQGICCIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHMLSEHIMAMRAGKKGMVSSAAVARNCTQESNISILEISSD--QPLSDRLKVLPGENFDPIPHQLLRKYVGYARHYVHPNLSAEAAQVLQDFYLELRKQNQSADSTPITTRQLESLIRLTEARARLELREKATESDAEDVVDIMKHSLADTYSDEFGRLDFDRSQLGSGMSNRSKVKKFVVALNQIAERSHRTLFDLPELRQLAKELQIQVVDFEGFISALNEQGYLLKKGHKKYQLQT 887

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:NCBI gene;Acc:103047810])

HSP 1 Score: 637.106 bits (1642), Expect = 0.000e+0
Identity = 359/796 (45.10%), Postives = 507/796 (63.69%), Query Frame = 1

Query:  172 LVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV------FANNIS---SISNSDLPNI---YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSN----CLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGS--TFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
            L SN  +  +  +F +  ++E++  V +I+ F  YF+  +++L   + IE K   ++DY DL  ++ I+  + +   E +    +I+  + LA+H ++       A+ +     +     P I   +I+ RI N+ P+     L+AN  G F++++G VV+V+ +KP+C ++ F C +C + Q + LPD  K+  P++C  + C+ + F P + S  T+T+D+Q I++QE  SD              D+   GRIP+T+ C L +DLVD+CVPGD V +TGI+   +         GSG N    C+F L ++ N++   KG          S  A  EFS+KDLY I+ I ++ +LFKL+V SLCP+IYGH LVKA L LALFGG  K+ +DKNR+ IRG+ H+L+VGDPGLGKSQMLQ+ C ++PR +Y+CG + T++GLTVS S+D+ SG  ALEAGALV+ D G CCIDEFDKM   QH +LLEAMEQQSIS+AKAG+VC L ARTS++AAANP  GHYNK KTV+ENLKM + LLSRFDLV+I+LD PNE  D  LS H++++   +    SS+++ +  T   +    E  S     +RL     E+ D IP QLLRKY+ YA+ YVHP LS+EAA +LQ+FYL LRK+    D TPITTRQLES++RLTEA+AR ELRE A E DA+DV ++M  S+   YSDE G L+F RSQ GSGMS  S  KK +  L   +ERS  + F+ P+++Q+A    I++ D E  ++ LNEQG+LLKKG   Y+L T
Sbjct:   13 LFSNLKFKSF--FFIIIGFVESTPYVEKIKTFEQYFTS-QIDLYDKDEIERKGSILVDYKDLLLNKQISAALPDLARELRDMPDKILDCLGLAIHQVLTKDLERHADELQVQEGLPTEATPIINIPHISARIYNYEPLTPLKMLRANIYGKFVAIRGTVVRVSNIKPLCSKMAFICNSCGDTQSLDLPDG-KYTTPSKCPQKECRGRIFTPNRSSPLTLTVDWQTIKVQELISD--------------DQRESGRIPRTIECELTQDLVDSCVPGDMVTITGIIKVSN-------EEGSGRNKKDKCMFLLYINANSVSNSKGQKSKSASEPESQGASVEFSLKDLYGIQEIQAQEDLFKLIVNSLCPAIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCNVSPRGIYVCGNTTTSSGLTVSLSRDSGSGDYALEAGALVLGDQGICCIDEFDKM-GNQHQALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHMLSEHIMAMRAGKKGMVSSAAVARNCTQESNISILEISSDQPLSDRLKVLPGENFDPIPHQLLRKYVGYARHYVHPNLSAEAAQVLQDFYLELRKQNQSADSTPITTRQLESLIRLTEARARLELREKATESDAEDVVDIMKHSLADTYSDEFGRLDFDRSQLGSGMSNRSKVKKFVVALNQIAERSHRTLFDLPELRQLAKELQIQVVDFEGFISALNEQGYLLKKGHKKYQLQT 782

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Match: mcm2 (minichromosome maintenance complex component 2 [Source:NCBI gene;Acc:103045462])

HSP 1 Score: 297.745 bits (761), Expect = 8.131e-87
Identity = 200/574 (34.84%), Postives = 291/574 (50.70%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC--LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I+VRI N   + +  +L+   +   I   G V     V P    VK+ C  C            +   P  C     + +S  P +   ++TV  +YQ I +QE+                  K   GR+P++ + IL+ DLVD+C PGDE+ +TGI        N +  S + +N   +F  V+  N+I R    V +         AE + +D+ AI A+  +  + + + AS+ PSIYGHE +K  L LALFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    +A R+V+  G   +  GLT    +        LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H +                  H   KE G    E +   +      IP +LLRKYI YAK+ V PKL+    + +   Y  LRK        PIT R +ESM+R+ EA AR  LR+   E D      +MLES +
Sbjct:  260 IHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCSFILGPFFQSQNQEVKPGSC----PECQSLGPFEINMEQTVYQNYQRITIQESPG----------------KVAAGRLPRSKDAILLADLVDHCKPGDEIELTGIY------HNNYDGSLNMANGFPVFATVILANHIARKDDRVAV---------AELTDEDVKAIVALSKDERIGERIFASIGPSIYGHEDIKRGLALALFGGEAKNPGGKHKV--RGDINVLMCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVMAAANPIGGRYDPSLTFSENVDLTEPIVSRFDVLCVVRDTVDPVQDEMLARFVVGSHIKH-----------------HPSNKEGGVAGLEEVVLPNSSDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVQEDDVNMAIRVMLESFI 779

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Match: mcm2 (minichromosome maintenance complex component 2 [Source:NCBI gene;Acc:103045462])

HSP 1 Score: 297.745 bits (761), Expect = 9.054e-87
Identity = 200/574 (34.84%), Postives = 291/574 (50.70%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC--LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I+VRI N   + +  +L+   +   I   G V     V P    VK+ C  C            +   P  C     + +S  P +   ++TV  +YQ I +QE+                  K   GR+P++ + IL+ DLVD+C PGDE+ +TGI        N +  S + +N   +F  V+  N+I R    V +         AE + +D+ AI A+  +  + + + AS+ PSIYGHE +K  L LALFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    +A R+V+  G   +  GLT    +        LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H +                  H   KE G    E +   +      IP +LLRKYI YAK+ V PKL+    + +   Y  LRK        PIT R +ESM+R+ EA AR  LR+   E D      +MLES +
Sbjct:  269 IHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCSFILGPFFQSQNQEVKPGSC----PECQSLGPFEINMEQTVYQNYQRITIQESPG----------------KVAAGRLPRSKDAILLADLVDHCKPGDEIELTGIY------HNNYDGSLNMANGFPVFATVILANHIARKDDRVAV---------AELTDEDVKAIVALSKDERIGERIFASIGPSIYGHEDIKRGLALALFGGEAKNPGGKHKV--RGDINVLMCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVMAAANPIGGRYDPSLTFSENVDLTEPIVSRFDVLCVVRDTVDPVQDEMLARFVVGSHIKH-----------------HPSNKEGGVAGLEEVVLPNSSDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVQEDDVNMAIRVMLESFI 788

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Match: mcm2 (minichromosome maintenance complex component 2 [Source:NCBI gene;Acc:103045462])

HSP 1 Score: 296.975 bits (759), Expect = 1.311e-86
Identity = 200/574 (34.84%), Postives = 291/574 (50.70%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC--LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I+VRI N   + +  +L+   +   I   G V     V P    VK+ C  C            +   P  C     + +S  P +   ++TV  +YQ I +QE+                  K   GR+P++ + IL+ DLVD+C PGDE+ +TGI        N +  S + +N   +F  V+  N+I R    V +         AE + +D+ AI A+  +  + + + AS+ PSIYGHE +K  L LALFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    +A R+V+  G   +  GLT    +        LEAGALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T +EN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H                 +  H   KE G    E +   +      IP +LLRKYI YAK+ V PKL+    + +   Y  LRK        PIT R +ESM+R+ EA AR  LR+   E D      +MLES +
Sbjct:  260 IHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCSFILGPFFQSQNQEVKPGSC----PECQSLGPFEINMEQTVYQNYQRITIQESPG----------------KVAAGRLPRSKDAILLADLVDHCKPGDEIELTGIY------HNNYDGSLNMANGFPVFATVILANHIARKDDRVAV---------AELTDEDVKAIVALSKDERIGERIFASIGPSIYGHEDIKRGLALALFGGEAKNPGGKHKV--RGDINVLMCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVMAAANPIGGRYDPSLTFSENVDLTEPIVSRFDVLCVVRDTVDPVQDEMLARFVVGSH-----------------IKHHPSNKEGGVAGLEEVVLPNSSDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVQEDDVNMAIRVMLESFI 779

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:ZFIN;Acc:ZDB-GENE-120927-1])

HSP 1 Score: 637.491 bits (1643), Expect = 0.000e+0
Identity = 363/813 (44.65%), Postives = 517/813 (63.59%), Query Frame = 1

Query:  136 SSTKKVNILKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYF-SCLKL-NLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVF--------------ANNISS---ISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTR---CVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA---EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMD-----TMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKL 2481
            SS+    +L+T+L   CPY GW +YFP E Y  +   V ++E F  +F + L+L N + IE K   ++D+ +L     +T  +    ++      R++  M LA+H +                   I+S   +  ++LP +     I N+ P+ +  NL+AN  G  ++++G VV+V  +KP+C R+ F C  C  EQ++ LP   KF +PT+   C +  C+S++F P + S  T T+D+Q I++QE               +H ++   GRIP+T+ C L  DLVD+CVPGD + +TGIV  + AS++  ++  +   C+F L +    +   KG  + D   E++      +FS+K+LYA++ I ++P+LF+LLV S+CP+IYGHELVKA L LALFGGV ++G DKNR+ +RG+ H+LIVGDPGLGKSQMLQ+ C IAPR VY+CG + TTAGLTV+ SKD  SG  ALEAGALV+ D G CCIDEFDKM   QH +LLEAMEQQSIS+AKAG+VC+L ARTS++AAANP  GHYNK+KTV+ENLKM + LLSRFDLV+I++D P+E  D  LS HV+++H  + +   +S  R        T S  S     G +  +RL     E+ D +P  LLRKY+ YA++YV P LS+EAA  LQ+FYL LR++ H  DGTPITTRQLES++RLTEA+AR ELRE A ++DA DV ++M  S     SDELG L+F R+Q GSGMS  SA+K+ ++ L   SE+  ++ F    ++Q+A +  ++++D E  +++LN QGFLL KG   Y+L
Sbjct:   55 SSSCHARVLQTTLDDFCPYPGWKLYFPSEVYCNSGGIVTKVEVFEKFFFARLELYNKDEIEEKGSILVDFKELVEDHCLTVAMPTLADDLAETPDRVLQYMGLAVHQVYLHCTPRLEIRISDLEEQKITSHGAVLRANLPTLPYRQIIYNYEPLTQLKNLRANCYGRLVAIRGTVVRVGNIKPLCTRLAFSCNACGTEQVLRLPYG-KFTLPTKRVKCADEDCRSRTFMPNRRSQLTETVDWQNIKVQEL--------------MHGEQREAGRIPRTVECELTHDLVDSCVPGDVITLTGIV--KVASSDEGRNKSNKDKCMFLLYIQAVAVSNTKGQ-RSDGGGEDTAPGVALDFSLKELYAVQEIQAQPHLFRLLVHSICPTIYGHELVKAGLALALFGGVQRYGTDKNRIPVRGDPHVLIVGDPGLGKSQMLQAVCNIAPRGVYVCGNTTTTAGLTVTLSKDGPSGDYALEAGALVLGDQGLCCIDEFDKMP-NQHQALLEAMEQQSISLAKAGVVCSLPARTSIVAAANPVCGHYNKSKTVSENLKMGSALLSRFDLVFILVDTPDEERDHVLSEHVMAMHAGKRMLAGASVSRAAAPGLKLTASSSSDDVLGGLSLSDRLKARRGEALDPVPHSLLRKYVGYARRYVRPCLSAEAAQTLQDFYLELRRQHHGGDGTPITTRQLESLIRLTEARARLELRENATKEDADDVIDIMKHSFSDTLSDELGTLHFERTQHGSGMSNRSAAKRFVTALARCSEQICNTMFTMQQLQQLARDIGLQVADFEGFISSLNTQGFLLHKGSKVYQL 848

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008164.1 (pep scaffold:Pmarinus_7.0:GL490771:48:5221:1 gene:ENSPMAG00000007367.1 transcript:ENSPMAT00000008164.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 208.764 bits (530), Expect = 2.169e-59
Identity = 150/473 (31.71%), Postives = 235/473 (49.68%), Query Frame = 1

Query:  421 ILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSG-TALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLN 1833
            +L    AL  LV   N+         + Y+ +  +  +       L +  +G+ + ++G V K + V+P  +R    C   +        D               K +   PL+ E   ++  D+Q I LQE      +P          +K   G++P++ + +L  DLVD C PGD V V G           + S        F  +L  NN+ ++  +V      E+       V  +      HS+ N+F  L  SL PSI+GHE +K ++L  L GG  K  ++ +R  IRG+ ++L++GDP + KSQML+     APR++   G   +  GLT + + D ++G   LEAGA+V+ D G  CIDEFDKM+     ++ E MEQ  ++IAKAG+   L+AR SVLAAANP  G Y++ KT  EN+ +   LLSRFDL++I+LD+ +   D ++S HVL +H  +++ 
Sbjct:   10 LLAFQQALKELV--GNVDGTYAKQFESFYVGLEGSFGARHLSPRTLTSRFLGNMVCVEGIVTKCSLVRPKVVRSVHYCPATQKSIERKYSDLTSLDAFPSSAAYPTKDEESNPLETEYGLSIYRDHQTISLQE------MP----------EKAPAGQLPRSADVVLDDDLVDRCKPGDRVQVIGTFRCLPGKKAGYTSG------TFRTILIGNNVKQMNKEVVPTFSGED-------VNKIKTFSKTHSK-NIFDQLSKSLAPSIHGHEYIKKAVLCLLLGGTEKILDNGSR--IRGDINVLLIGDPSVAKSQMLRYVLHTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLGDRGVVCIDEFDKMTDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPIYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQTDPEYDREISDHVLRMHRYRAVG 448

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Match: mcm5 (minichromosome maintenance complex component 5 [Source:ZFIN;Acc:ZDB-GENE-021209-1])

HSP 1 Score: 202.216 bits (513), Expect = 3.878e-56
Identity = 146/477 (30.61%), Postives = 233/477 (48.85%), Query Frame = 1

Query:  772 DETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSEN-SYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAK-AGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLR-------KRRHFMDGTPITTRQLESMVRLTEAKARSELREIANE 2172
            D+   +DYQ ++LQE     P                 G +P+ +     R L D  VPG+ + V GI   + A   F +  G G +     +   N   R+ G + +D D    S       ++   I  + + P++++ +  S+ PSIYG   +K ++   L GG  K   D   +  RG+ ++L++GDPG  KSQ+L+     +P  VY  G   + AGLT S  +D  +    +E GA+V++D G  CIDEFDKM      ++ EAMEQQ+IS  +  G+   L++R SVLAAAN   G ++ +K   EN+     +LSRFD+++I+ D  NE  D  L++HV+++H    LN  +    QM  +                           I    L+K+IAY +    P++S+EA   L+  Y+ +R       + R   +  PIT RQLE++VR++E++A+  L+  A E
Sbjct:   25 DKCKCVDYQTLKLQEAPDAVP----------------HGEMPRHMQLYCDRYLCDRVVPGNRITVMGIYSIKKA---FTKMQGKGRDRTGAGIR--NPYLRVVG-ITVDTDGAGRSMGIALHPQEEEEIRQLAASPSVYETIARSIAPSIYGFMDIKKAIASLLIGGSRKRLPDG--LTRRGDINLLLLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVMRDPATRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISTLRIGGITTTLNSRCSVLAAANSVFGRWDDSKG-EENIDFMPTILSRFDMIFIIKDEHNEKRDMILAKHVMNVH----LNAKT----QMQAVE------------------------GEIELSTLKKFIAYCRSKCGPRMSAEACEKLKNRYVLMRSGAREHDRDRDHRNSIPITVRQLEAIVRISESQAKMRLQPFATE 444

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006035.1 (pep scaffold:Pmarinus_7.0:GL477570:19772:33072:1 gene:ENSPMAG00000005356.1 transcript:ENSPMAT00000006035.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.586 bits (488), Expect = 1.127e-51
Identity = 163/552 (29.53%), Postives = 261/552 (47.28%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKS-KSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAE-FSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSG-TALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKR-RHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVK 2193
            +++AN IG  ++++G V +  +VKP+ +   + C  C  E    +     F     C +R C++ KS   L  +S  +  + +Q +++QE                H D+   G IP+ +   +  +      PGD + +TGI +            G     L    L  + +      VKM+   +N  D E  S  +L  I    +E + ++ L AS+ P IYGHE VK +LLL L GGV +       + IRGN +I ++GDPG+ KSQ+L     +APRS Y  G   +  GLT +  +D  +G   LE GALV++D+G CCIDEFDKM+     S+ E MEQQ+ISIAK       S RT VL       G      +    +K+ A LLSRFDL++++ D+P+   D +L++H+  +H  Q  ++  S    +D                                +L+R+YIA  ++   P +    A+ +   Y+ +RK  R   D T  + R L +++RL+ A AR  L ++  ++D  + +
Sbjct:  150 DVKANSIGRLVTVRGVVTRATEVKPMMVVATYTCDQCGAETYQPIAST-SFMPLALCPSRDCQTNKSGGRLYLQSRGSKFVKFQELKIQE----------------HSDQVPVGCIPRAMTVCVRGENTRLAQPGDHISITGIFLPVLKQGFRAMQQG----LLSETFLEAHRV------VKMNKTEDNELDVEELSESELRQI----TEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDR---SPRGMKIRGNINICLMGDPGVAKSQLLCYIDRLAPRSQYTTGRGSSGVGLTAAVLQDPLTGEMTLEGGALVLADHGVCCIDEFDKMADSDRTSIHEVMEQQTISIAKVTWGVGASTRTRVLQLVGYGRGGGGSCCSRWLGIKLPAALLSRFDLLWLIQDKPDRDNDIRLAQHITYVH--QHCHQPPSQHTPLDM-------------------------------KLMRRYIALCQRR-QPAVPDTLADYITAAYVEMRKEARVSKDTTFTSARTLLAILRLSTALARLRLVDVVEKEDVNEAR 633

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006014.1 (pep scaffold:Pmarinus_7.0:GL477570:19772:33072:1 gene:ENSPMAG00000005356.1 transcript:ENSPMAT00000006014.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.637 bits (444), Expect = 5.713e-46
Identity = 161/556 (28.96%), Postives = 264/556 (47.48%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKS-KSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAE-FSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSG-TALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAE----NLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKR-RHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVK 2193
            +++AN IG  ++++G V +  +VKP+ +   + C  C  E    +     F     C +R C++ KS   L  +S  +  + +Q +++QE                H D+   G IP+ +   +  +      PGD + +TGI +            G     L    L  + +      VKM+   +N  D E  S  +L  I    +E + ++ L AS+ P IYGHE VK +LLL L GGV +       + IRGN +I ++GDPG+ KSQ+L     +APRS Y  G   +  GLT +  +D  +G   LE GALV++D+G CCIDEFDKM+     S+ E MEQQ+ISIAK       S R ++ +     T    +A  + +     L + A LLSRFDL++++ D+P+   D +L++H+  +H  Q  ++  S    +D                                +L+R+YIA  ++   P +    A+ +   Y+ +RK  R   D T  + R L +++RL+ A AR  L ++  ++D  +++
Sbjct:  150 DVKANSIGRLVTVRGVVTRATEVKPMMVVATYTCDQCGAETYQPIAS-TSFMPLALCPSRDCQTNKSGGRLYLQSRGSKFVKFQELKIQE----------------HSDQVPVGCIPRAMTVCVRGENTRLAQPGDHISITGIFLPVLKQGFRAMQQG----LLSETFLEAHRV------VKMNKTEDNELDVEELSESELRQI----TEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDR---SPRGMKIRGNINICLMGDPGVAKSQLLCYIDRLAPRSQYTTGRGSSGVGLTAAVLQDPLTGEMTLEGGALVLADHGVCCIDEFDKMADSDRTSIHEVMEQQTISIAKVTWGVGASTR-ALCSDGGGRTVAAGRASRIDDCVWLALMLPAALLSRFDLLWLIQDKPDRDNDIRLAQHITYVH--QHCHQPPSQHTPLDM-------------------------------KLMRRYIALCQRR-QPAVPDTLADYITAAYVEMRKEARVSKDTTFTSARTLLAILRLSTALARLRLVDVVEKEDVNEMR 636

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Match: MCM2 (Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000000119])

HSP 1 Score: 284.648 bits (727), Expect = 3.746e-83
Identity = 193/586 (32.94%), Postives = 301/586 (51.37%), Query Frame = 1

Query:  508 INVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA-EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDN-DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT----EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLS---------YGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            I+VRI++F  I     L+ + + S + + G V +   V P    VKF CL C +       D  +    + C N  CKSK   P +   ++TV  +YQ + LQE     P                 GR+P+    IL+ DLVD   PG+EV VTGI    +   N +  +G     +F  ++  N+I R +G+   +   E   D   ++ ++      I  +  +   +++S+ PSIYGH  +K ++  +LFGGV K  N K+  +IRG+ ++L++GDPG  KSQ+L+     A R+V+  G   +  GLT S  KD       LE GALV++D G C IDEFDKM+ Q   S+ EAMEQQSISI+KAG+V  L AR S++AAANPN G YN    +A+N+ ++ P+LSRFD++ ++ D  +E  D +L+  V+  H     E   +R    ++     +  S  ++     +E+L+            +E    IP +LL KYI YA+  ++PKL     + +   Y  LR+        PIT R LES++R+ E+ A+  L E  +  D     +++++S +
Sbjct:  293 IHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTN--CKSKG--PFRVNGEKTVYRNYQRVTLQEAPGTVP----------------PGRLPRHREVILLADLVDVSKPGEEVEVTGIYKN-NYDGNLNAKNGF---PVFATIIEANSIKRREGNTANE--GEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKH--SIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKN----NGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFV 846

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Match: MCM4 (Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p [Source:SGD;Acc:S000006223])

HSP 1 Score: 282.722 bits (722), Expect = 5.868e-82
Identity = 205/619 (33.12%), Postives = 299/619 (48.30%), Query Frame = 1

Query:  448 TLVFANNISSISNSDLPNI---YINVRIANFSPICKSLN-LQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDS--------ENSYD-------AEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK----RRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSD 2232
            +L+  NN+    + DL  I   +  VR  N    CK +  L  N I   I+LKG V++   V P      F+C  C +   V + D      P RC    C   +   L  +  +   D QVI+LQET    P                +G+ P +++  +  +LVD+C  GD + VTG   +     N  Q         +  V+HV  +     D ++DVD+        +N  D        + + +DL  I  + +  +L+ LL  S+ PSIY  E VK  +LL LFGG  K      R   RG+ +IL+ GDP   KSQ+LQ    I PR VY  G   +  GLT   ++D D+    LE+GALV+SD G CCIDEFDKMS    + L E MEQQ+ISIAKAG++  L+AR+S+LA+ANP    YN    V EN+ +  PLLSRFDLVY++LD+ +E  D +L++H+ +L+ E                                    H    D +P + L  YI+YAK+++HP ++  A   L   Y+ +RK     R        TTRQLESM+RL EA A+ +L+ +   +D ++   L+  ++    +D
Sbjct:  282 SLIVDNNL----DYDLDEIETKFYKVRPYNVGS-CKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI-DRGVIQEPARCERIDCNEPNSMSLIHNRCSFA-DKQVIKLQETPDFVP----------------DGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVS----DKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRY--RGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPE--------------------------------HISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATD 839

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Match: MCM6 (Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p [Source:SGD;Acc:S000003169])

HSP 1 Score: 279.641 bits (714), Expect = 2.217e-80
Identity = 192/602 (31.89%), Postives = 299/602 (49.67%), Query Frame = 1

Query:  526 NFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVV-LPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGD-------EVIVT--------GIVMTESASTNFHQSSGSGSNCLFN----------------LVLHVNNICRLKGDVKMDVDS--------------------ENSYDAE-----FSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK--RRHFMDGT-PITTRQLESMVRLTEAKARS 2148
            N   + +  ++++ +IGS +S+ G V + ++V+P   +  F C  C+   IV  +   +K+  PT C N  C++++F  L  +  +  +D+Q +R+QE  ++ P                 G +P+TL+ IL  D V+   PGD       E++V         G+  + +  T     +  G N                    L  HV +I    G    D +S                    +N  D E      S  ++  ++ +  + +++  LV S+ P+++GHE VK  +LL + GGV K  +    + +RG+ +I +VGDP   KSQ L+     APRSVY  G + + AGLT +  +D + G   +EAGAL+++DNG CCIDEFDKM      ++ EAMEQQ+ISIAKAG+   L+ARTS+LAAANP  G YN+  ++  NL M+AP++SRFDL +++LD  NE +D++L+ H++ LH                 M      + P S                   + LR+YI YA+ +  P L+ EA + L E Y  LRK   + F   +  IT RQLESM+RL+EA AR+
Sbjct:  269 NLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCR--AIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVT-RSRFLDWQKVRIQENANEIPT----------------GSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHK--STVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLH-----------------MKRDEAIEPPFSA------------------EQLRRYIKYARTF-KPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARA 813

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Match: MCM5 (Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase [Source:SGD;Acc:S000004264])

HSP 1 Score: 235.343 bits (599), Expect = 3.819e-66
Identity = 156/499 (31.26%), Postives = 256/499 (51.30%), Query Frame = 1

Query:  787 IDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDA--EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMD-------GTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYS-DELGILN 2250
            ID Q ++LQE     P+                G +P+ L     R L +  +PG  V + GI    ++          G N    + +    I  L   ++ DV++ + +++   F+ ++      +   P L+++L  S+ PSI+G+E +K +++  L GG  K   D  R  +RG+ ++L++GDPG  KSQ+L+    ++P +VY  G   + AGLT S  +D  +    LE GA+V++D G  CIDEFDKM  +   ++ EAMEQQ+ISIAKAG+   L++RTSVLAAANP  G Y+  K+  +N+     +LSRFD+++I+ D  NE  D  ++ HV+++HT  +                ++M  +             +E+   I  + +++YI Y +    P+LS +AA  L   ++++RK+    +         PIT RQLE+++R+TE+ A+ EL  IA E+   +   L   S M   S D +G LN
Sbjct:  251 IDQQFLKLQEIPELVPV----------------GEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKIL--GIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMR--LRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNA----------------NAMQNQ------------QEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLN 701

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Match: MCM3 (Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000000758])

HSP 1 Score: 228.024 bits (580), Expect = 1.025e-62
Identity = 181/597 (30.32%), Postives = 289/597 (48.41%), Query Frame = 1

Query:  556 LQANQIGSFISLKGNVVKVNQVKPVCIR-VKFRCLTCK--NEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCL--FNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTA-LEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLH------------TEQSLNRSSSSIRQMDT------------------------MSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMG 2220
            L A  +   +S++G V K + V+P  IR V +   T +                +PT  +     ++  +   E   +  ID+Q I +QE     P                 G++P++++ IL  DLVD   PGD V V G+  +  A    +QS+   SN L  F  ++  N +  L    +    +      +F +++   I  +  + ++F +L  SL PSIYGH+ +K ++LL L GGV K  N +N   +RG+ +IL+VGDP   KSQ+L+     A  ++   G   +  GLT + + D ++G   LEAGA+V++D G  CIDEFDKM+     ++ E MEQQ+++IAKAG+   L+AR SV+AAANP  G Y+  +   +N+ +   LLSRFDL++++ D  NE+ D  +S HVL  H              + LN S +     D                           F+ + +        + +Y   E    +    LRKY+ YAK+ V P+L+ EA N++ + Y  LR   +    +PIT R LE+++RL  A A+  L +  N+ DAK    L+  +++G
Sbjct:  171 LTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPA----------------GQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAG-GMNQSN---SNTLIGFKTLILGNTVYPLH--ARSTGVAARQMLTDFDIRN---INKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEK--NLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDN-TKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLG 739

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Match: EDO35060 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMI2])

HSP 1 Score: 297.36 bits (760), Expect = 1.195e-87
Identity = 212/636 (33.33%), Postives = 324/636 (50.94%), Query Frame = 1

Query:  316 KKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            K+  +IDYN L + +   +V+  F  E      +I  E   A   +V A       N D     I+VRIA    + +  +L+   +   I   G V     + P    +K+ C  C            +   P  C    C+S+   P +   ++T+  +YQ I++QE+ S                K   GR+P+  + IL+ DLVD+C PGDE+ +TGI      S+  ++S+G     +F  ++  N I   K D KM V S        + +D+ AI A+  +  + + ++AS+ PSIYGHE +K +L L+LFGGV K    K++  IRG+ ++L+ GDPG  KSQ L+     APR+V+  G   +  GLT    +   +    LEAGALV++D G C IDEFDKM+     S+ EAMEQQSISI+KAG+V +L AR S+LAAANP  G Y+ + T AEN+ ++ P+LSRFD++ ++ D  + + D  L+R V++ H     N   +   + + M  H  T    +                IP  LL+KY+ YA++ VHP+L++   + + + +  LRK        PIT R +ESM+R+ E+ A+  LRE   E D      +MLES +
Sbjct:  151 KQSLVIDYNILANEQ---QVLAYFLPEAPTEMLQIFDE---AAKEVVLA----MFPNYDRITTEIHVRIAELPLMEELRSLRQLHVNQLIRTGGVVTSSTGIMPQLSVIKYDCPKCSFILGPFFQGSDQEVKPGSCPE--CQSRG--PFEINMEQTLYQNYQKIKIQESPS----------------KVAAGRLPRYKDVILMADLVDSCKPGDEIELTGIYKINYDSS-LNRSNGFP---VFATIIEANFIT--KQDDKMAVTS-------LTDEDIKAINALSKDERIGERIIASIGPSIYGHEDIKRALALSLFGGVAKDPGGKHK--IRGDINVLLCGDPGTAKSQFLKYVEKTAPRAVFTTGQGASAVGLTAYVQRHPVTKEWTLEAGALVLADKGMCLIDEFDKMNDADRTSIHEAMEQQSISISKAGIVTSLQARCSILAAANPIGGRYDPSLTFAENVDLTEPILSRFDILCVVRDTVDAIQDELLARFVVNSHVRHHPNTPEN---EDEDMEVHMFTLRRNA----------------IPQDLLKKYMIYARERVHPRLNNMDQDKVAKMFADLRKESMATGSIPITVRHIESMIRMAESHAKMHLREYVMEDDVNMAIRVMLESFI 722

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Match: EDO33971 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQR1])

HSP 1 Score: 285.034 bits (728), Expect = 3.318e-83
Identity = 198/648 (30.56%), Postives = 333/648 (51.39%), Query Frame = 1

Query:  415 RIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTG--IVMTESAS---------TNFHQSSGSGSNC----------LFNLVLHVNNIC--------RLKG-DVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT--EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTP-------ITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDEL 2238
            R+   +C A+    FA +   +     PN    V   +     K   L + +IGS + + G VV+ + V P  +   F CL C+   I  +   +K+  PT C N +C++++   L + +++  +D+Q +R+QET ++ P                 G IP+++  IL  + V+    GD+   TG  IV+ + A          T   Q+SG G             + +L   ++ +         R  G D+  D  +  +   + + ++   I  +  + NL++ ++ S+ P+I+G++ VK  +LL LFGGV K   +K   ++RG+ +I +VGDP   KSQ L+     + R+VY  G + + AGLT +  KD +S    +EAGA++++DNG CCIDEFDKM  +   ++ EAMEQQ+IS+ KAG+  +L+ARTSVLAAANP  G Y++ K++ +NL MSAP++SRFDL +I++D  NEV+D  ++R ++ LH+  EQS+ R                             Y   E         +++Y+ +A+++  P ++ EA + + E Y  LR+R    DG+        IT RQLESM+RL+EA AR   ++    +  K+   L+ +S++ V + ++
Sbjct:   79 RVFPYLCQAVRN--FARDRGQVP----PNKEFYVSFIDLPTRHKIRELTSQKIGSLLRISGQVVRTHPVHPELVTATFTCLDCQT-VIKDVEQQFKYTQPTVCRNPICQNRARFAL-DINKSRYVDFQKVRIQETQAELP----------------RGCIPRSVEVILRAEAVEQAQAGDKCDFTGTLIVVPDIAQLATPGTRSETGQRQTSGEGYEAEGVRGLKALGVRDLTYRLSFLACSVQATNPRFGGKDLDGDDMTAEAIKKQMTPQEWQKIYEMSRDKNLYQNIINSIFPTIHGNDEVKRGVLLMLFGGVPKKTLEK--TSLRGDINICVVGDPSTAKSQFLKHVEEFSARAVYTSGKASSAAGLTAAVVKDEESSEFVIEAGAMMLADNGVCCIDEFDKMDPRDQVAIHEAMEQQTISLTKAGVKASLNARTSVLAAANPIGGRYDRTKSLKQNLNMSAPIMSRFDLFFILVDECNEVVDYAIARRIVDLHSRREQSVER----------------------------VYAVDE---------VQRYLTFARQF-KPTITKEAQDYMVEQYKHLRER----DGSSTTKSAWRITVRQLESMIRLSEAMARLYCQDKVEPKHVKEAYRLLNKSIIRVETPDI 658

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Match: EDO42446 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1E9])

HSP 1 Score: 259.225 bits (661), Expect = 4.865e-76
Identity = 194/585 (33.16%), Postives = 291/585 (49.74%), Query Frame = 1

Query:  496 PNIYINVRIANFSPICKSLNL----QANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKN--------EQIVVLPDDYKFAVPTRC-VNRVCKSKSFEPLKE--SDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLH-----VNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKL--LVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVL-SLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDA 2181
            PNI+  VR++N  PIC  L      +++ +G F+++ G V++V+ +K +    +F C  CK         EQ   +P       PT C     C S  F  L E  S+ T   DYQ I++QE                   K   G IP+++  +L  DLVD+C  GD+V ++G+VM             +   C   +V       VNN  R+   V  ++  E  +D EF  K        H +  L     ++AS CP +YG   VK ++ L L GGV +      RV  RG SH+L++GDPG GKSQ L+ +  I PRSV   G   T+AGLTV+  +D+     LEAGALV++D G CCIDEF+ +      S+ EAMEQQ+IS+AKAGMVC L+ RT++LAA NP  G  +  ++++ N  +++PLLSRFDLV+++ D  NE  D  +S  +L       S  + + ++  MD                                  L+ YI +AK  + P+L++++  +L+++Y   +++    +    T R LES++RL +A AR   RE    QDA
Sbjct:    5 PNIH--VRLSNL-PICPELKRSTIPKSSDMGRFLAVSGTVIRVSSIKMLEHEREFICSRCKYVFSAQADFEQFYTIPK------PTSCPSGEGCTSNKFNCLSEPGSNPTSCRDYQEIKIQE----------------QVQKLAVGTIPRSMWVVLEDDLVDSCKAGDDVTISGVVMRRWWPVI------AEVKCDLEVVFKANHVSVNNEQRIGAIVTEEMKQE--FD-EFWSK--------HKDKPLSGRNHILASFCPQVYGLYAVKLAVTLILMGGVQRVDASGTRV--RGESHMLLIGDPGTGKSQFLKYSAKIMPRSVLTTGIGSTSAGLTVAAVRDSGEWQ-LEAGALVLADGGLCCIDEFNSIREHDRGSIHEAMEQQTISVAKAGMVCKLNTRTTILAATNPK-GQLDIDQSLSVNTALASPLLSRFDLVFVLQDVKNEDWDRIVSSFILEGKGVRMSAEKPAEALWGMDR---------------------------------LQAYICHAKT-LEPQLNTDSNRVLRQYY-QCQRQADTRNAARTTLRLLESLIRLAQAHARLMYREHVTVQDA 508

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Match: EDO34425 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPE9])

HSP 1 Score: 250.751 bits (639), Expect = 4.588e-71
Identity = 187/565 (33.10%), Postives = 283/565 (50.09%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKF-AVPTRCVNRVCKSKSFEPLKESDETVTI-DYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVM-TESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSE-PNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSG-TALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT-----EQS-----LNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYG-HKESCDN-IPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDG----TPITTRQLESMVRLTEAKARSELREIANEQDAK 2184
            +L +  IGS + ++G V K + V+P  +R    C   K   I    D     AVPT  V    K +   PL+      T  D+Q   +QE     P                 G++P++++ I   DLVD C PGD V V G      S  + F  +SG+     F  VL VNN+  +  +V             FS  D+  I+       ++F++L  SL PSI+GHE +K ++L  L GG  K   +  R  +RG+ +IL++GDP   KSQML+     APR++   G   +  GLT + + D ++G   LEAGA+V++D G  CIDEFDKMS     ++ E MEQ  ++I+KAG+   L+AR SVLAAANP  G Y++ K   +N+ M   LLSRFDL++I+LD+ +   D ++S HVL +H      EQ          S  +   D          P    H+ + +G  K+  D  +    ++KYI  AK  + P L+  AA+++ + Y  LR + +  +     TP+T R LE+M+RL+ A A++ + +   E DA+
Sbjct:  112 SLSSRYIGSMVCVEGIVTKCSLVRPKVVRSVHYCPKTKKTLIRKYTDMTSLEAVPTSSVY-PTKDEDGNPLETEYGLCTYKDHQTFTIQEMPERAPA----------------GQLPRSVDIIADNDLVDKCKPGDRVQVIGTYRCLPSKRSGF--TSGT-----FRTVLIVNNVQVMSKEVA----------PNFSASDISKIKKFSKSKQDVFEVLAKSLAPSIHGHEFIKKAVLCLLLGGTEKVLENGTR--LRGDINILLIGDPSTAKSQMLRYVLHSAPRAIPTTGRGSSGVGLTAAVTTDPETGDRRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHAKLNARCSVLAAANPVFGRYDEFKNPMDNIGMQDSLLSRFDLLFIVLDQMDPDNDRRISEHVLRIHRYRKPGEQEGEALPFGEESDVLATRDPDQEEEDEDTPVYEKHDPMLFGKQKDKKDKFVSMAFMKKYIHVAKA-IKPALTKPAADLISKAYSELRDQENIGNDKAKTTPVTARTLETMIRLSTAHAKARMSKTITEGDAQ 639

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Match: EDO37946 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEF9])

HSP 1 Score: 243.817 bits (621), Expect = 3.855e-69
Identity = 185/569 (32.51%), Postives = 280/569 (49.21%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSK--SFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDL--YAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGV--TKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTA-LEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK-RRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDE 2235
            N++A+ IG    ++G V++  +VKPV     + C  C  E    +     F     C +  CK+         ++  +  + +Q +++QE                H D+   G IP+++  I   +      PGD V VTGI +     T F Q +      L +  L  + I R+            + D E    DL    I A+ +E + +  L +SL P IYGHE +K +LLL L GGV  T  G     + IRGN +IL++GDPG+ KSQML     +APRS Y  G   T  GLT +  KD  +G   LE GALV++D G CCIDEFDKM      ++ E MEQQ++SIAKAG++  L+AR S+LAAANP  G YN  K+  +N+++ A LLSRFDL++++ D+P++  D +L++H+  +H                    HS    P S +            D +   L+R+YIA  K+   P +  E ++ +   Y+ +RK  R+  D T  + R L +++RL  A AR  L ++  ++D  +   LM  S   +  DE
Sbjct:  150 NVKADCIGKLTVVRGIVMRCTEVKPVVEVATYTCDQCGAESYQTI-QSQTFMPLLMCPSEECKTNRAGGRLYLQTRGSKFVKFQELKIQE----------------HSDQVPVGHIPRSMTIIAKGENTRLATPGDHVSVTGIFLP-MMKTGFRQMT---QGLLSDTFLEAHRIVRMN----------KTEDDEMPTDDLSDEEIRALSTEADFYDKLASSLAPEIYGHEDIKKALLLLLVGGVDCTPHG-----MKIRGNINILLMGDPGVAKSQMLSYIDRLAPRSQYTTGRGSTGVGLTAAVMKDPLTGEMILEGGALVLADKGVCCIDEFDKMMDGDRTAIHEVMEQQTVSIAKAGIMTTLNARVSILAAANPAYGRYNPKKSAEQNIQLPAALLSRFDLLWLIQDKPDKENDLRLAQHITYVHQ-------------------HS--AHPPSHY------------DPLDMNLMRRYIAACKEK-QPIVPGELSDYIVSAYVEMRKDARNNHDTTFTSARTLLAVLRLATALARLRLADVVEKEDVNEAMRLMEMSKASLSDDE 648

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:NCBI gene;Acc:101154800])

HSP 1 Score: 637.106 bits (1642), Expect = 0.000e+0
Identity = 357/798 (44.74%), Postives = 514/798 (64.41%), Query Frame = 1

Query:  160 LKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV---FANNISSISNSDLP------NI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDY-KFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYD-------AEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
             +T+L ++CPY GW +YF  E ++++S +V +I+ F  YF+  +++L   + IE +   ++DY DL     +++ + +     +   + ++  + LA+H ++        + + + +LP      NI +I+ R+ N+ P+     L+A+  G  + +KG VV+V+ ++P+C R+ FRC TC +   + LP  + K+A PT+C+   C+S+SF PL+ S  T+T+D+Q+I++QE               +  ++   GRIP+T+ C L  DL D+CVPGD VIVTGIV       N   S G+   C+F L +   ++   KG +   V  E+S          EFS+K+LYA++ I S+P+L +LLV SLCP+IYGH LVKA+L LALFGG  K    KN V +RG+ HILIVGDPGLGKSQMLQ+ C +APR +Y+CG S +T GLTVS S+D  +G  ALEAGALV++D G CCIDEFDK+  QQ A LLEAMEQQS+S+AKAG+V +L ARTSV+AAANP  GHYN+ KTV+ENLKM + LLSRFD+V+++LD P+E  D  LS HV++    +  +  +   R         + +       ERL     ++ D IP  LLRKYI+YA++YVHP LS EAA  LQ+FYLSLR +    D TPITTRQLES++RLTEA+A+ ELRE+A   DA+DV E+M  S+   YSD LG L+F RSQ GSGMS+ SA+K+L++ L +H++R+G   F+   ++ +A   NIK+ D + ++++LNEQGFLLKKGP  Y+L T
Sbjct:   72 FQTTLDASCPYKGWSLYF-TEGFIQSSPSVEKIKVFEKYFTS-RIHLFDKDEIERQGSVLVDYADLTGDRSVSQALPDVVTALKEQPEVMLSCLGLAIHQVLTTDLEKQAAELHDEELPVSTPIINIPHISARLYNYEPLTPLRTLRASVFGRLVCVKGTVVRVSNIRPLCTRMAFRCQTCTSA--MSLPLQHGKYATPTKCIQPGCRSRSFAPLRSSALTLTVDWQIIKVQEL--------------MGGEQRETGRIPRTVECHLTSDLCDSCVPGDTVIVTGIVRV----NNDGSSRGNKDQCMFLLYIDATSVSNTKGQLSKSVGEESSGSLEDRSGGEEFSLKELYAVQEIQSQPDLLRLLVHSLCPAIYGHSLVKAALALALFGGRQKHMG-KNSVPVRGDPHILIVGDPGLGKSQMLQAVCNVAPRGIYVCGNSTSTTGLTVSLSRDAGTGDYALEAGALVLADQGLCCIDEFDKLGNQQQA-LLEAMEQQSVSLAKAGIVSSLPARTSVVAAANPVGGHYNRGKTVSENLKMGSALLSRFDVVFLLLDIPDESHDRCLSEHVMANRAGKGRSSGAVVTRANGESETSILLQHSDMPLSERLQVPAGQTLDLIPACLLRKYISYARQYVHPTLSPEAAQTLQDFYLSLRSQASSADSTPITTRQLESLIRLTEARAKLELREMATRGDAEDVVEIMKHSLADTYSDGLGNLDFERSQLGSGMSQRSAAKRLVNALHSHAQRTGQKQFDLQTLRSMADKLNIKVGDFQGLLSSLNEQGFLLKKGPKLYQLQT 845

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Match: mcm8 (minichromosome maintenance 8 homologous recombination repair factor [Source:NCBI gene;Acc:101154800])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 334/791 (42.23%), Postives = 485/791 (61.31%), Query Frame = 1

Query:  160 LKTSLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNL---EMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLV---FANNISSISNSDLP------NI-YINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDY-KFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLT 2487
             +T+L ++CPY GW +YF  E ++++S +V +I+ F  YF+  +++L   + IE +   ++DY DL     +++ + +     +   + ++  + LA+H ++        + + + +LP      NI +I+ R+ N+ P+     L+A+  G  + +KG VV+V+ ++P+C R+ FRC TC +   + LP  + K+A PT+C+   C+S+SF PL+ S  T+T+D+Q+I++QE               +  ++   GRIP+T+ C L  DL D+CVPGD VIVTGIV   +         G+   C+F L +   ++   KG V                      + +     +F  L    C       LVKA+L LALFGG  K    KN V +RG+ HILIVGDPGLGKSQMLQ+ C +APR +Y+CG S +T GLTVS S+D  +G  ALEAGALV++D G CCIDEFDK+  QQ A LLEAMEQQS+S+AKAG+V +L ARTSV+AAANP  GHYN+ KTV+ENLKM + LLSRFD+V+++LD P+E  D  LS HV++    +  +  +   R         + +       ERL     ++ D IP  LLRKYI+YA++YVHP LS EAA  LQ+FYLSLR +    D TPITTRQLES++RLTEA+A+ ELRE+A   DA+DV E+M  S+   YSD LG L+F RSQ GSGMS+ SA+K+L++ L +H++R+G   F+   ++ +A   NIK+ D + ++++LNEQGFLLKKGP  Y+L T
Sbjct:   56 FQTTLDASCPYKGWSLYF-TEGFIQSSPSVEKIKVFEKYFTS-RIHLFDKDEIERQGSVLVDYADLTGDRSVSQALPDVVTALKEQPEVMLSCLGLAIHQVLTTDLEKQAAELHDEELPVSTPIINIPHISARLYNYEPLTPLRTLRASVFGRLVCVKGTVVRVSNIRPLCTRMAFRCQTCTSA--MSLPLQHGKYATPTKCIQPGCRSRSFAPLRSSALTLTVDWQIIKVQEL--------------MGGEQRETGRIPRTVECHLTSDLCDSCVPGDTVIVTGIVRVNN--------DGNKDQCMFLLYIDATSVSNTKGIV---------------------CQMLMQTQWVFTFL--PFC------SLVKAALALALFGGRQKH-MGKNSVPVRGDPHILIVGDPGLGKSQMLQAVCNVAPRGIYVCGNSTSTTGLTVSLSRDAGTGDYALEAGALVLADQGLCCIDEFDKLGNQQQA-LLEAMEQQSVSLAKAGIVSSLPARTSVVAAANPVGGHYNRGKTVSENLKMGSALLSRFDVVFLLLDIPDESHDRCLSEHVMANRAGKGRSSGAVVTRANGESETSILLQHSDMPLSERLQVPAGQTLDLIPACLLRKYISYARQYVHPTLSPEAAQTLQDFYLSLRSQASSADSTPITTRQLESLIRLTEARAKLELREMATRGDAEDVVEIMKHSLADTYSDGLGNLDFERSQLGSGMSQRSAAKRLVNALHSHAQRTGQKQFDLQTLRSMADKLNIKVGDFQGLLSSLNEQGFLLKKGPKLYQLQT 789

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Match: mcm2 (minichromosome maintenance complex component 2 [Source:NCBI gene;Acc:101173930])

HSP 1 Score: 294.664 bits (753), Expect = 1.304e-85
Identity = 216/641 (33.70%), Postives = 319/641 (49.77%), Query Frame = 1

Query:  310 EIKKHAIIDYNDLCSSEYI-TKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKS-FEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNC--LFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMM 2217
            E K+  +++Y DL + E++    + E   E          E+ LA++          I++       I+VR++N   + +   L+   +   I   G V     V P    VK+ C  C            +   P  C    C+S+  FE   E  ETV  +YQ I +QE+                  K   GR+P++ + IL+ DLVD+C PGDE+ +TGI        N +  S + +N   +F  V+  N+I R    V +         AE + +D+ AI A+  +  + + + AS+ PSIYGHE +K +L L+LFGG  K    K++V  RG+ ++L+ GDPG  KSQ L+    +A R+V+  G   +  GLT    +   S    LEAGALV++D G C IDEFDKM+     S+ EAMEQQSISI+KAG+V +L AR +V+AAANP  G Y+ + T AEN+ ++ P++SRFD++ ++ D  + V D  L+R V+  H                 +  H  TKE G    E +   +      IP  LLRKYI YAK+ VHPKL+    + +   Y  LRK        PIT R +ESM+R+ EA A+  LR+   E D      +MLES +
Sbjct:  213 ENKESLVVNYEDLAAREHVLAYFLPEAPAEMLKVFDEAAKEVVLAMYP-----KYDRIAHE------IHVRVSNLPLVEEIRALRQLHLNQLIRTSGVVSCCTGVLPQLSMVKYNCSKCSFVLGPFFQSQNQEVKPGSCPE--CQSQGPFEVNME--ETVYQNYQRITIQESPG----------------KVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYH------NNYDGSLNMANGFPVFATVILANHISRRDEGVAV---------AELTDEDVKAIVALSKDECIGERIFASVAPSIYGHEDIKRALALSLFGGEPKNPGGKHKV--RGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDADRTSIHEAMEQQSISISKAGIVTSLQARCTVMAAANPIGGRYDPSLTFAENVDLTEPIVSRFDVLCVVRDTVDPVQDEMLARFVVGSH-----------------IKHHPSTKEGGVALEE-MVLPNTTDVSPIPQDLLRKYIIYAKERVHPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHAKMHLRDYVLEDDVNMAIRVMLESFI 787

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Match: mcm4 (minichromosome maintenance complex component 4 [Source:NCBI gene;Acc:101173977])

HSP 1 Score: 292.352 bits (747), Expect = 2.609e-85
Identity = 210/615 (34.15%), Postives = 296/615 (48.13%), Query Frame = 1

Query:  412 QRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVK----MDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK---RRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSD 2232
            Q +I    +A++ L F     S+         I VR  N        NL    I   I+L G V++ +Q+ P      F+C  C     V + D  + A P  C N  C +     L   + +V  D Q+I++QE+  D P                 G+ P T       DLVD   PGD V +TGI        +  QS     N       H++ I   K D K    +D D E     E  V+ L  + A   +P++++ L ++L PSIY HE +K  +LL LFGG  K  +   R   R   +IL+ GDPG  KSQ+LQ    + PR  Y  G   +  GLT    KD ++    L+ GALV+SDNG CCIDEFDKMS    + L E MEQQ++SIAKAG++C L+ART+VLAAANP    +N  KT  EN+++   LLSRFDL+++MLD  +E  D +L+ H++SL+ +        S  QM+   F  M                          +L+ YIAYA+ Y+ P+LS EA+  L E Y+ +RK    R  +   P   RQLES++RL EA A+    E     D ++ K L  E++    +D
Sbjct:  226 QEVIPTFDMAVNELFFERFPDSVLE-----YQIQVRPYNALKTKNMRNLNPEDIDQLITLGGMVIRTSQLIPEMQEAFFQCQVCAFSARVEV-DRGRIAEPAVCRN--CNNTHSMTLVH-NRSVFSDKQMIKIQESPEDMPA----------------GQTPHTTILYAHNDLVDKVQPGDRVNITGIYRAVPMRVHPRQS-----NVRSVYKTHIDAIHFRKTDEKRLHGLDQDGEQKLFTEDRVQTLKELAA---KPDVYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTAVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQ--------SEEQMEE-EFLDMA-------------------------VLKDYIAYARTYISPRLSEEASQALIEAYVDMRKIGSGRGMVSAYP---RQLESLIRLAEAHAKVRFSEKVETIDVEEAKRLHREALKQSATD 770

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BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Match: mcm4 (minichromosome maintenance complex component 4 [Source:NCBI gene;Acc:101173977])

HSP 1 Score: 292.352 bits (747), Expect = 2.710e-85
Identity = 210/615 (34.15%), Postives = 296/615 (48.13%), Query Frame = 1

Query:  412 QRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVK----MDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRK---RRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSD 2232
            Q +I    +A++ L F     S+         I VR  N        NL    I   I+L G V++ +Q+ P      F+C  C     V + D  + A P  C N  C +     L   + +V  D Q+I++QE+  D P                 G+ P T       DLVD   PGD V +TGI        +  QS     N       H++ I   K D K    +D D E     E  V+ L  + A   +P++++ L ++L PSIY HE +K  +LL LFGG  K  +   R   R   +IL+ GDPG  KSQ+LQ    + PR  Y  G   +  GLT    KD ++    L+ GALV+SDNG CCIDEFDKMS    + L E MEQQ++SIAKAG++C L+ART+VLAAANP    +N  KT  EN+++   LLSRFDL+++MLD  +E  D +L+ H++SL+ +        S  QM+   F  M                          +L+ YIAYA+ Y+ P+LS EA+  L E Y+ +RK    R  +   P   RQLES++RL EA A+    E     D ++ K L  E++    +D
Sbjct:  190 QEVIPTFDMAVNELFFERFPDSVLE-----YQIQVRPYNALKTKNMRNLNPEDIDQLITLGGMVIRTSQLIPEMQEAFFQCQVCAFSARVEV-DRGRIAEPAVCRN--CNNTHSMTLVH-NRSVFSDKQMIKIQESPEDMPA----------------GQTPHTTILYAHNDLVDKVQPGDRVNITGIYRAVPMRVHPRQS-----NVRSVYKTHIDAIHFRKTDEKRLHGLDQDGEQKLFTEDRVQTLKELAA---KPDVYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTAVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQ--------SEEQMEE-EFLDMA-------------------------VLKDYIAYARTYISPRLSEEASQALIEAYVDMRKIGSGRGMVSAYP---RQLESLIRLAEAHAKVRFSEKVETIDVEEAKRLHREALKQSATD 734

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BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Match: SMESG000004906.1 (SMESG000004906.1)

HSP 1 Score: 1503.42 bits (3891), Expect = 0.000e+0
Identity = 752/756 (99.47%), Postives = 754/756 (99.74%), Query Frame = 1

Query:  229 METSQTVMRIEAFSSYFSCLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFXXXXXXXXXXXXXXXXXXXXXXQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLTAGF 2496
            METSQTVMRIEAFS YFSCLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFIS+KGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKD+DSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGST HERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFSRSQSGSGMSKSSASKKLISLLQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLTAGF
Sbjct:    1 METSQTVMRIEAFSGYFSCLKLNLEMIEIKKHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANNISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISVKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDSDSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTLHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFSRSQSGSGMSKSSASKKLISLLQAHSERSGSSHFNYPDIKQIAINANIKLSDIENIVNTLNEQGFLLKKGPYSYKLLTAGF 756

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BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Match: SMESG000060238.1 (SMESG000060238.1)

HSP 1 Score: 307.375 bits (786), Expect = 2.200e-91
Identity = 196/568 (34.51%), Postives = 297/568 (52.29%), Query Frame = 1

Query:  553 NLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGG----VTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTA-LEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGT-PITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDEL 2238
            NL    +   +++ G V++++++ P  I+  F+C  C N  +  +P +    +     N+ C++K  + +   +    ID Q+++LQE+  D P                 G  P T+     +DLVD   PGD V VTGI    S   N  Q        +F   L V +  + K  +   +D E   +A+ S + +  I A+  +P+L++ L  ++ P+IYG+E +K  LL+ LFGG      K G  +N   +R N H+L+ GDPG  KSQ+LQ    + PR  Y  G   +  GLT   +KD ++G++ L++GAL +SDNG CCIDEFDKM+    + L E MEQQS+SIAKAG++C L ARTSVLAAANP    ++  KT+ EN+++   LLSRFDL++++LD  +E  D+KL+RH++ L+                    H+ T EPG+                +   +LR YIAYAK+ +HP LS EA N + E Y+ +RK  +   G      RQLES++RL EA AR  L +     D  + + L  E++     D L
Sbjct:  186 NLNPEDLDQLVTVNGLVIRLSEIIPEMIKAHFKCSVCNN--VTKVPCERGRIIDPEFCNQ-CQAKHTQQIVH-NCCEFIDKQMVKLQESPEDMP----------------AGETPHTVVLYCYQDLVDTIQPGDRVTVTGIYRAASQRENSKQRV---IKAVFKTYLDVLHFQKSKNRL---IDEE---EAKLSQERVVEIRALSQKPDLYERLSGAIAPTIYGNETIKKGLLMMLFGGRVKETKKLGAGEN---MRSNIHVLLCGDPGTSKSQLLQYVYNLTPRGQYTSGKGSSKVGLTAYITKDPETGSSTLQSGALALSDNGICCIDEFDKMTDTTRSVLHEVMEQQSLSIAKAGIICQLHARTSVLAAANPIGSCWDNKKTIIENIQLPPTLLSRFDLIFLILDPQDEQYDAKLARHIVGLYCG------------------HNKTTEPGT----------------VDTAMLRDYIAYAKENIHPILSEEAENYVTEEYVEMRKVGNAGKGQISAYPRQLESLIRLAEAHARMRLSDQVTVADCLEARRLQREALKQAAIDPL 687

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Match: SMESG000038798.1 (SMESG000038798.1)

HSP 1 Score: 273.092 bits (697), Expect = 9.241e-79
Identity = 180/611 (29.46%), Postives = 303/611 (49.59%), Query Frame = 1

Query:  526 NFSPICKSLNLQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSK-SFEPLKESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMT---------------ESASTNFHQSSGSGSNCLFNL---------------VLHVNNICRLKGDVKMDVDSENSYDA---EFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHF---MDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGI 2244
            +F  +    NL+   +G  +  +G V++ + V P  +   F+C  C    +  +   + F  PT C N  C ++  FE + E  + V  D+Q +R+QET ++ P                 G IP+ ++ IL  + V+N  PGD+   TG ++                E+      +   SG   L  L               V  VNN      D  M+ + E +YD+   + + +++  +  ++ +PNL K +   L P+ YG++ VK  LLL LFGGV K   +  +  +RG+ +I IVGDP   KSQ L+     +PR+VY  G + + AGLT +  +D +SG   +EAGAL++++NG CCIDEFDKM  +   ++ EAMEQQ+IS+ KAG+   L+A+TSVLAAANP  G Y++++++ +N+ +SAP++SRFDL ++++D   E +D ++++ +          +S + I   D                                  +++YI +A+ +  P+++ EA  ++   Y  +R+R           IT RQLES+VRL+EA AR    +   E D  +   L+ +S++ V   ++ +
Sbjct:  112 DFPTLTNLRNLRMGNLGKLVKFRGQVIRSHGVHPELVLGTFKCQDCGT-VVKNIEQQFIFTKPTICGNPQCMNRLKFELIPEQSKYV--DFQKVRVQETQNELP----------------RGCIPRCMDVILRNETVENAQPGDQSEFTGSLIIIPDISQLTTPGSRTLETKQIKLSEGYDSGVTGLKELGVRDLTYRMAFLANHVATVNNKYLQTED--MNEEGELTYDSLMKKLTEQEVNKVLTMNQDPNLVKNMCDCLFPTTYGNDEVKRGLLLMLFGGVPKVTEEGTK--LRGDINICIVGDPSTAKSQFLKRIAGFSPRAVYTSGKASSAAGLTAAVVRDQESGEFVIEAGALMLANNGVCCIDEFDKMEVRDQVAIHEAMEQQTISLTKAGIKATLNAKTSVLAAANPVGGRYDRSRSLRQNISLSAPIMSRFDLFFVLIDECTEQVDHEIAKRITESQRPVDPEKSDTRIYNEDD---------------------------------IQRYITFARCF-EPRVTEEAFKLMVTEYAKMRERDAASGSRSAWRITVRQLESLVRLSEATARMRFSDFVEECDVVEANRLLSKSIIRVEQPDINL 665

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Match: SMESG000023015.1 (SMESG000023015.1)

HSP 1 Score: 260.381 bits (664), Expect = 3.027e-74
Identity = 192/598 (32.11%), Postives = 296/598 (49.50%), Query Frame = 1

Query:  463 NNISSISNSDLPNIYINVRIANFSPICKSLNL----QANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKNEQIVVLPD-DYKFAV--PTRCVNRV--CKSKSFEPLKESDETVTI--DYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFK-LLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELMLESMMG 2220
            N++      ++PN    VRI +  P C  ++     ++  +G F+S+   VV+   ++ +  + ++ C  CK   I    + D  F +  P  C N    C S +F+ ++ S  +     + Q I +QE                     + G +P+T+  IL  DLVD   PGD+VI+ G V+    +   +        C+  LV+  N I      V   + +  S  +E  +      E  H +    + LL++ +CP IYG   +K +L L L G    F N    + +RG SH+LIVGDPG  KSQ L+ A  + PRSV   G   T AGLTV+  K++  G +LEAGALV++D G CCIDEF  +      ++ EAMEQQSIS+AKAG+VC L  R SV+AA NP  G+Y+  +++  N  +++PLLSRFDL++++LD  NE  DS +S  +L+  T +S                                   KES +    + L+ Y AY +   HPK++ EA+ IL+++Y  +RK         IT R LES++RL+++ AR  +RE   E+DA     +M  ++ G
Sbjct:   91 NDMGVTLGKEIPNC--QVRITSL-PFCDEISRTSIPKSVDVGKFLSVAATVVRAGSIQVLEFQREYICKKCKFSVICEFSESDASFTINPPKFCSNYSSGCVSSAFDIVESSKLSPKFCRNRQEINVQE----------------QIKYLSFGCMPRTIKVILDDDLVDLVKPGDDVIINGTVIRRWNNLRVNDE------CVIQLVILANEI----QIVNHTISNNYSIKSEMKLDFQLFWEKYHGKSFTARNLLISQMCPLIYGMYFLKLALALVLCGSENCFFNG---MKVRGESHMLIVGDPGTAKSQFLKFAHKLTPRSVLTTGIGSTNAGLTVTAVKES-GGWSLEAGALVLADGGICCIDEFTSIRECDKVAIHEAMEQQSISVAKAGIVCKLKTRCSVIAATNPK-GNYDITQSITANTAIASPLLSRFDLIFLLLDNCNESWDSCVSDFILNHQTFES----------------------------------SKESFN---LEKLKSYFAYIRSTFHPKMTPEASVILEKYYTWMRKSEITNSLDRITMRFLESLIRLSQSHARFMMREFVKEEDAVMAVAVMESTVYG 617

[Close]

BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Match: SMESG000005389.1 (SMESG000005389.1)

HSP 1 Score: 242.276 bits (617), Expect = 4.056e-68
Identity = 181/608 (29.77%), Postives = 300/608 (49.34%), Query Frame = 1

Query:  460 ANNIS--SISNSDLPNIYINVRIANFSPICKSLN-LQANQIGSFISLKGNVVKVNQVKPVCIRVKFRCLTCKN--EQIVVLPDDYKFAVPTRC----------VNRVCKSKSFEPLK-ESDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCILIRDLVDNCVPGDEVIVTGIV-MTESASTNFHQSSGSGSNCLFNLVLHVNNICRLKGDVK-MDV-DSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSIYGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQMLQSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGT-ALEAGALVISDNGCCCIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNTGHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHTEQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLLRKYIAYAKKYVHPKLSSEAANILQEFYLSLR-------KRRHFMDGTPITTRQLESMVRLTEAKARSELREIANEQDAKDVKELM 2202
            AN+++   + N +LP+I I +++ +     KSL  +++NQI   I + G VV  + +K     +  RC  C+     + V P    + +P +C          V +  +S   +P   E D+    D+Q+++LQE   + P                 G +P+     + R L +  VPG+ V V GI  + +  S N  +  G   + +  L + + N    +  +  + V D E     EFS+K           P + +++  S+ P IYG+  +K ++   LFGG  K       V +RG+ +++++GDPG  KSQ+L+     AP +VY  G   + AGLT S  +D+ + +  +E GA+V++D G  CIDEFDKM      ++ EAMEQQ+ISIAKAG+   L++R SVLAAAN   GH+++ K   EN+     ++SRFD+++++ D  +E  D ++  HV+S+H        ++ + +   +S  S+T E G                 +P   L+KYIA+ +    P+L+ EA  I+   Y+S+R       K        PIT RQLE++VR+ E+ A+  L     E DA++   L 
Sbjct:  100 ANDVTYPRLENENLPSIQIMLKLDSHP---KSLREIKSNQISKLIKISGVVVSASGIKSKAATLTLRCKGCQQYLPSVSVKPGLNGYVLPRKCIASASSARFGVGQTAQSCPVDPYYIEPDKCKCNDFQILKLQEAPENVP----------------HGEMPRHSQLFVDRYLCEKAVPGNRVTVVGISSIIQQDSMNMPKD-GVKHSYIRVLNVEIENTGSTRSGISSLGVTDKEEKEFREFSLK-----------PGVHEIIARSIAPGIYGNPDIKKAIACLLFGGSRK--KMPEGVFLRGDINMMMLGDPGTAKSQLLKFVEQCAPIAVYTSGKGSSAAGLTASVIRDSATRSFVMEGGAMVLADGGVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTMLNSRCSVLAAANSVFGHWDETKG-DENIDFMPTIMSRFDMIFVVKDVYDEKRDKQIVEHVMSVHMGDG---QAADVNE--NISLDSLTAETGI----------------MPVLKLKKYIAFCRDQCGPRLTPEALKIITNHYVSMRSGASEYEKETGKNTSIPITIRQLEAIVRIAESLAKMRLAPFGVEADAREAIRLF 652

The following BLAST results are available for this feature:

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Celegans
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MCM8	0.000e+0	47.07	minichromosome maintenance 8 homologous recombinat...	[more]
MCM8	0.000e+0	47.07	minichromosome maintenance 8 homologous recombinat...	[more]
MCM8	0.000e+0	46.58	minichromosome maintenance 8 homologous recombinat...	[more]
AL035461.4	0.000e+0	46.44	novel protein	[more]
MCM8	0.000e+0	44.60	minichromosome maintenance 8 homologous recombinat...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mcm-2	7.158e-87	34.49	DNA helicase [Source:UniProtKB/TrEMBL;Acc:Q7K7J6]	[more]
mcm-2	7.158e-87	34.49	DNA helicase [Source:UniProtKB/TrEMBL;Acc:Q7K7J6]	[more]
mcm-4	8.654e-83	33.10	DNA replication licensing factor mcm-4 [Source:Un...	[more]
mcm-4	8.654e-83	33.10	DNA replication licensing factor mcm-4 [Source:Un...	[more]
mcm-6	7.407e-74	29.61	DNA replication licensing factor mcm-6 [Source:Un...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Mcm6	2.413e-87	33.05	gene:FBgn0025815 transcript:FBtr0070952	[more]
Mcm2	2.134e-85	32.39	gene:FBgn0014861 transcript:FBtr0081827	[more]
dpa	5.380e-77	32.35	gene:FBgn0015929 transcript:FBtr0345797	[more]
dpa	5.380e-77	32.35	gene:FBgn0015929 transcript:FBtr0088982	[more]
rec	7.580e-74	27.84	gene:FBgn0003227 transcript:FBtr0334595	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mcm8	0.000e+0	46.39	minichromosome maintenance 8 homologous recombinat...	[more]
mcm2	7.373e-85	34.84	minichromosome maintenance complex component 2 [So...	[more]
mcm4	2.808e-84	34.27	minichromosome maintenance complex component 4 [So...	[more]
mcm6l	3.005e-81	32.31	MCM6 minichromosome maintenance deficient 6, like ...	[more]
mcm6l	3.634e-81	32.31	MCM6 minichromosome maintenance deficient 6, like ...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pde10a	0.000e+0	45.64	phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-...	[more]
pde10a	0.000e+0	45.64	phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-...	[more]
pde10a	0.000e+0	45.53	phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-...	[more]
pde10a	0.000e+0	45.81	phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-...	[more]
pde10a	0.000e+0	44.64	phosphodiesterase 10A [Source:Xenbase;Acc:XB-GENE-...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Mcm8	0.000e+0	46.50	minichromosome maintenance 8 homologous recombinat...	[more]
Mcm8	0.000e+0	46.73	minichromosome maintenance 8 homologous recombinat...	[more]
Mcm2	6.766e-84	32.71	minichromosome maintenance complex component 2 [So...	[more]
Mcm6	9.312e-84	31.12	minichromosome maintenance complex component 6 [So...	[more]
Mcm6	1.505e-83	32.09	minichromosome maintenance complex component 6 [So...	[more]

BLAST of DNA replication licensing factor MCM8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|D3ZVK1\|MCM8_RAT	0.000e+0	46.38	DNA helicase MCM8 OS=Rattus norvegicus OX=10116 GN...	[more]
sp\|Q9CWV1\|MCM8_MOUSE	0.000e+0	46.50	DNA helicase MCM8 OS=Mus musculus OX=10090 GN=Mcm8...	[more]
sp\|Q9UJA3\|MCM8_HUMAN	0.000e+0	47.07	DNA helicase MCM8 OS=Homo sapiens OX=9606 GN=MCM8 ...	[more]
sp\|I0IUP3\|MCM8_CHICK	0.000e+0	46.04	DNA helicase MCM8 OS=Gallus gallus OX=9031 GN=MCM8...	[more]
sp\|E1BPX4\|MCM8_BOVIN	0.000e+0	47.05	DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE...	[more]

BLAST of DNA replication licensing factor MCM8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3JYB5	0.000e+0	49.75	DNA helicase MCM8 OS=Lingula unguis OX=7574 GN=LOC...	[more]
A0A0L8GIE4	0.000e+0	48.08	MCM domain-containing protein OS=Octopus bimaculoi...	[more]
A0A3B3T3T5	0.000e+0	47.47	Minichromosome maintenance 8 homologous recombinat...	[more]
G3GSC8	0.000e+0	47.01	DNA replication licensing factor MCM8 OS=Cricetulu...	[more]
A0A1U7QLN4	0.000e+0	46.77	DNA helicase MCM8 isoform X1 OS=Mesocricetus aurat...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mcm8	0.000e+0	45.21	minichromosome maintenance 8 homologous recombinat...	[more]
mcm8	0.000e+0	45.10	minichromosome maintenance 8 homologous recombinat...	[more]
mcm2	8.131e-87	34.84	minichromosome maintenance complex component 2 [So...	[more]
mcm2	9.054e-87	34.84	minichromosome maintenance complex component 2 [So...	[more]
mcm2	1.311e-86	34.84	minichromosome maintenance complex component 2 [So...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mcm8	0.000e+0	44.65	minichromosome maintenance 8 homologous recombinat...	[more]
ENSPMAT00000008164.1	2.169e-59	31.71	pep scaffold:Pmarinus_7.0:GL490771:48:5221:1 gene:...	[more]
mcm5	3.878e-56	30.61	minichromosome maintenance complex component 5 [So...	[more]
ENSPMAT00000006035.1	1.127e-51	29.53	pep scaffold:Pmarinus_7.0:GL477570:19772:33072:1 g...	[more]
ENSPMAT00000006014.1	5.713e-46	28.96	pep scaffold:Pmarinus_7.0:GL477570:19772:33072:1 g...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
MCM2	3.746e-83	32.94	Protein involved in DNA replication; component of ...	[more]
MCM4	5.868e-82	33.12	Essential helicase component of heterohexameric MC...	[more]
MCM6	2.217e-80	31.89	Protein involved in DNA replication; component of ...	[more]
MCM5	3.819e-66	31.26	Component of the Mcm2-7 hexameric helicase complex...	[more]
MCM3	1.025e-62	30.32	Protein involved in DNA replication; component of ...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO35060	1.195e-87	33.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33971	3.318e-83	30.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42446	4.865e-76	33.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34425	4.588e-71	33.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37946	3.855e-69	32.51	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mcm8	0.000e+0	44.74	minichromosome maintenance 8 homologous recombinat...	[more]
mcm8	0.000e+0	42.23	minichromosome maintenance 8 homologous recombinat...	[more]
mcm2	1.304e-85	33.70	minichromosome maintenance complex component 2 [So...	[more]
mcm4	2.609e-85	34.15	minichromosome maintenance complex component 4 [So...	[more]
mcm4	2.710e-85	34.15	minichromosome maintenance complex component 4 [So...	[more]

BLAST of DNA replication licensing factor MCM8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000004906.1	0.000e+0	99.47	SMESG000004906.1	[more]
SMESG000060238.1	2.200e-91	34.51	SMESG000060238.1	[more]
SMESG000038798.1	9.241e-79	29.46	SMESG000038798.1	[more]
SMESG000023015.1	3.027e-74	32.11	SMESG000023015.1	[more]
SMESG000005389.1	4.056e-68	29.77	SMESG000005389.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30001391 ID=SMED30001391|Name=DNA replication licensing factor MCM8|organism=Schmidtea mediterranea sexual|type=transcript|length=2777bp
CGTTTTATATAAAATTGAATGAATTCCAACCGCCAAAACTTTAATAGTCG
ACGTGGTCGTGGATATTTCGGCAGAAGATTTAAAAAGTCTACAAATTATA
TACCAAAGTCTGAAGGAGATATTTCATTAGATATATCTAGCACGAAAAAG
GTTAACATTTTAAAAACTTCACTTGTATCCAATTGTCCTTATCATGGCTG
GTTAATTTATTTTCCATTGGAAGAGTATATGGAAACTTCTCAAACCGTTA
TGCGAATCGAAGCTTTCTCAAGTTATTTTAGTTGTCTGAAGCTCAATCTA
GAAATGATCGAAATTAAAAAGCATGCAATTATTGATTACAATGACTTGTG
TTCATCGGAATATATAACTAAAGTAATTCATGAATTTAAAAATGAATTCC
AATTTAATTGCCAAAGAATTATTTTGGAAATGTGTCTTGCTTTGCATACT
CTGGTATTTGCAAATAATATTTCATCAATTTCTAATTCAGATTTACCAAA
CATTTATATCAATGTTCGAATAGCGAATTTTTCACCAATATGTAAATCAT
TAAATTTACAAGCAAATCAAATTGGAAGTTTTATTTCCTTGAAAGGAAAT
GTTGTCAAAGTTAATCAGGTTAAACCAGTTTGTATAAGAGTAAAATTTCG
CTGTTTAACATGTAAAAATGAGCAAATTGTTGTATTACCCGATGATTACA
AGTTTGCAGTGCCTACAAGATGTGTAAATAGAGTTTGCAAATCAAAAAGT
TTTGAACCTTTAAAAGAATCGGATGAAACTGTCACGATTGATTATCAGGT
GATTCGGTTACAAGAGACGGGCTCCGATTGTCCTCTACCGTTTTCATCGA
ATTCCGAGTCCATTCATCATGACAAGACAAATGAAGGACGAATACCAAAA
ACTTTAAATTGCATTTTAATAAGGGATTTAGTTGATAACTGTGTCCCTGG
GGATGAAGTTATAGTTACTGGTATTGTTATGACAGAGTCGGCATCTACTA
ACTTTCATCAATCCTCTGGATCGGGATCAAATTGCCTGTTTAATCTAGTG
CTTCACGTTAACAATATTTGCCGACTCAAAGGTGATGTTAAAATGGATGT
GGATAGTGAAAATTCGTACGATGCAGAATTTTCGGTTAAAGATCTTTATG
CAATCGAAGCTATTCATTCTGAACCAAATTTATTCAAACTATTAGTTGCA
AGCCTTTGTCCAAGCATATATGGTCATGAATTAGTCAAAGCAAGTTTGTT
GTTGGCTTTGTTTGGTGGGGTTACAAAATTCGGAAATGATAAAAATCGAG
TAGCGATTCGCGGGAATTCCCATATATTAATAGTTGGCGATCCAGGTCTT
GGTAAAAGTCAAATGTTACAATCTGCATGTGCAATTGCACCGAGGTCTGT
ATACATTTGTGGCGGTAGTGTGACTACTGCTGGATTGACAGTTTCATTTT
CTAAAGATAACGATTCTGGAACTGCTTTAGAAGCAGGAGCTTTAGTGATA
TCAGACAACGGTTGTTGTTGTATTGATGAATTTGATAAAATGAGTGCGCA
GCAGCACGCGTCATTATTGGAGGCGATGGAACAACAGAGCATTAGTATTG
CGAAAGCAGGAATGGTTTGTAATCTATCAGCAAGAACATCTGTTCTAGCC
GCTGCAAATCCTAATACTGGGCATTATAATAAGGCTAAAACAGTTGCAGA
GAATCTAAAAATGTCTGCACCTCTTTTATCCAGATTTGATCTGGTGTATA
TAATGCTTGATAGACCGAATGAAGTGTTGGATTCTAAATTGTCAAGACAT
GTTTTATCACTACACACTGAACAGTCTTTGAACAGATCATCTTCGAGTAT
TAGACAAATGGATACCATGTCGTTTCATTCGATGACAAAAGAACCTGGAT
CAACTTTTCATGAAAGATTGAGTTACGGACATAAGGAATCTTGTGATAAC
ATTCCTCCTCAACTGCTTAGAAAGTATATTGCTTATGCAAAAAAATATGT
CCATCCCAAGTTAAGCAGCGAAGCGGCTAATATTCTTCAAGAATTTTATC
TTTCATTGAGAAAACGCAGGCATTTTATGGATGGAACACCGATCACAACT
AGGCAGTTAGAATCGATGGTAAGATTAACTGAGGCTAAAGCCCGATCAGA
ATTAAGAGAAATTGCTAATGAACAAGATGCTAAAGATGTAAAGGAGCTAA
TGTTAGAAAGTATGATGGGAGTTTATAGTGATGAGCTTGGAATCTTGAAT
TTTTCACGATCACAATCTGGATCTGGCATGAGCAAATCTTCTGCTTCTAA
GAAGTTGATATCATTATTACAAGCACATAGCGAGAGATCGGGCTCTTCAC
ATTTTAATTATCCCGATATAAAACAAATTGCAATAAATGCAAACATAAAA
TTATCAGACATTGAGAATATCGTCAATACTCTCAATGAGCAAGGCTTTCT
TTTAAAAAAAGGTCCTTATTCATATAAGTTATTGACCGCTGGATTTTAGA
AATTAAGGACAAATTGTATTATAAAATAAACGTTTGTATTCCATTACTAG
TTTTAGTTTTATTTGGGATTTTTATTGTCTTAAAAGTAAATCGTAGAGCC
CAGTCGAATCTCCAGTAAAGATTTCGAACGGGATGGGATGGATAACATAA
AAATGAGAAATTAATATTTTACAATTATAATGCTACAATCAATTTTTAAT
GTATAAGAATTATTCATCAAGTGTGAATTGTACGGGAAACTTTCATCATT
TTTCGGTTAAAAATAAATCTTTTTTTC

protein sequence of SMED30001391-orf-1

>SMED30001391-orf-1 ID=SMED30001391-orf-1|Name=SMED30001391-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=827bp
MNSNRQNFNSRRGRGYFGRRFKKSTNYIPKSEGDISLDISSTKKVNILKT
SLVSNCPYHGWLIYFPLEEYMETSQTVMRIEAFSSYFSCLKLNLEMIEIK
KHAIIDYNDLCSSEYITKVIHEFKNEFQFNCQRIILEMCLALHTLVFANN
ISSISNSDLPNIYINVRIANFSPICKSLNLQANQIGSFISLKGNVVKVNQ
VKPVCIRVKFRCLTCKNEQIVVLPDDYKFAVPTRCVNRVCKSKSFEPLKE
SDETVTIDYQVIRLQETGSDCPLPFSSNSESIHHDKTNEGRIPKTLNCIL
IRDLVDNCVPGDEVIVTGIVMTESASTNFHQSSGSGSNCLFNLVLHVNNI
CRLKGDVKMDVDSENSYDAEFSVKDLYAIEAIHSEPNLFKLLVASLCPSI
YGHELVKASLLLALFGGVTKFGNDKNRVAIRGNSHILIVGDPGLGKSQML
QSACAIAPRSVYICGGSVTTAGLTVSFSKDNDSGTALEAGALVISDNGCC
CIDEFDKMSAQQHASLLEAMEQQSISIAKAGMVCNLSARTSVLAAANPNT
GHYNKAKTVAENLKMSAPLLSRFDLVYIMLDRPNEVLDSKLSRHVLSLHT
EQSLNRSSSSIRQMDTMSFHSMTKEPGSTFHERLSYGHKESCDNIPPQLL
RKYIAYAKKYVHPKLSSEAANILQEFYLSLRKRRHFMDGTPITTRQLESM
VRLTEAKARSELREIANEQDAKDVKELMLESMMGVYSDELGILNFSRSQS
GSGMSKSSASKKLISLLQAHSERSGSSHFNYPDIKQIAINANIKLSDIEN
IVNTLNEQGFLLKKGPYSYKLLTAGF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0006270	DNA replication initiation
GO:0006260	DNA replication

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000421	tail
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR041562	MCM_lid
IPR033762	MCM_OB
IPR001208	MCM_dom
IPR003593	AAA+_ATPase
IPR031327	MCM
IPR012340	NA-bd_OB-fold
IPR027417	P-loop_NTPase

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0000166	nucleotide binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001208	MCM domain	PRINTS	PR01657	MCMFAMILY	coord: 489..503 score: 67.31 coord: 568..576 score: 68.1 coord: 517..530 score: 81.18 coord: 541..553 score: 62.37 coord: 430..445 score: 53.23
IPR001208	MCM domain	PFAM	PF00493	MCM	coord: 377..598 e-value: 2.5E-86 score: 288.4
IPR001208	MCM domain	PROSITE	PS50051	MCM_2	coord: 387..594 score: 71.034
IPR031327	Mini-chromosome maintenance protein	SMART	SM00350	mcm	coord: 173..732 e-value: 2.1E-140 score: 482.5
IPR031327	Mini-chromosome maintenance protein	PANTHER	PTHR11630	DNA REPLICATION LICENSING FACTOR	coord: 34..822
IPR003593	AAA+ ATPase domain	SMART	SM00382	AAA_5	coord: 431..583 e-value: 3.9E-4 score: 29.7
None	No IPR available	GENE3D	G3DSA:2.20.28.10		coord: 206..252 e-value: 3.0E-29 score: 103.5
None	No IPR available	GENE3D	G3DSA:2.40.50.140		coord: 178..342 e-value: 3.0E-29 score: 103.5
None	No IPR available	PANTHER	PTHR11630:SF99		coord: 34..822
None	No IPR available	CDD	cd17759	MCM8	coord: 390..730 e-value: 5.72913E-145 score: 426.564
IPR041562	MCM, AAA-lid domain	PFAM	PF17855	MCM_lid	coord: 648..731 e-value: 6.4E-25 score: 87.4
IPR033762	MCM OB domain	PFAM	PF17207	MCM_OB	coord: 178..321 e-value: 4.7E-21 score: 74.9
IPR012340	Nucleic acid-binding, OB-fold	SUPERFAMILY	SSF50249	Nucleic acid-binding proteins	coord: 96..346
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 397..734