XendoU domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001357 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of XendoU domain-containing protein vs. TrEMBL
Match: A0A267FPC5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig015604g2 PE=4 SV=1) HSP 1 Score: 100.138 bits (248), Expect = 2.862e-22 Identity = 63/188 (33.51%), Postives = 97/188 (51.60%), Query Frame = 3 Query: 27 MSLFNS-----NLPFLVLIRFQHNDAAAYHNSVIRQKPLLR---TIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDEN-TIVEILEIVKYRSPSRFSSECLDKIDSAKEN--NIVAVPRYATEVLRGSWNPLYIIINVWS 557 M+LF N+ + +IRF + A YHNSV R +++ E L + R+E E R+ YG G++ FP+ + W E + EVRQ++WL+ DIVIVP+R + D+ ++EI + +R + F E L +++ E NIVA P Y +R SW+P Y++IN WS Sbjct: 1 MALFRGLEEPENVGYYAVIRFTQDIAYNYHNSVKRTASIIQRSHGGHECAFLPDVQRIEGDE-----------RRLYGYGVLYFPNFDAAKYWYECTNEVRQQDWLWSADIVIVPAR---GAFDKGMAVLEINDWSAFRDQTAFEDEYLKGLNNTTEGRWNIVACPDYLQYRMRSSWSPKYLVINQWS 174
BLAST of XendoU domain-containing protein vs. TrEMBL
Match: A0A267DNX7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig015604g1 PE=4 SV=1) HSP 1 Score: 98.9821 bits (245), Expect = 6.674e-22 Identity = 60/177 (33.90%), Postives = 93/177 (52.54%), Query Frame = 3 Query: 45 NLPFLVLIRFQHNDAAAYHNSVIRQKPLLR---TIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDEN-TIVEILEIVKYRSPSRFSSECLDKIDSAKEN--NIVAVPRYATEVLRGSWNPLYIIINVWS 557 N+ + +IRF + A YHNSV R +++ E L + R+E E R+ YG G++ FP+ + W E + EVRQ++WL+ DIVIVP+R + D+ ++EI + +R + F E L +++ E NIVA P Y +R SW+P Y++IN WS Sbjct: 12 NVGYYAVIRFTQDIAYNYHNSVKRTASIIQRSHGGHECAFLPDVQRIEGDE-----------RRLYGYGVLYFPNFDAAKYWYECTNEVRQQDWLWSADIVIVPAR---GAFDKGMAVLEINDWSAFRDQTAFEDEYLKGLNNTTEGRWNIVACPDYLQYRMRSSWSPKYLVINQWS 174
BLAST of XendoU domain-containing protein vs. TrEMBL
Match: A0A267G5A5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002947g3 PE=4 SV=1) HSP 1 Score: 93.5893 bits (231), Expect = 8.677e-20 Identity = 55/173 (31.79%), Postives = 95/173 (54.91%), Query Frame = 3 Query: 45 NLPFLVLIRFQHNDAAAYHNSVIRQKPLLRTIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDEN-TIVEILEIVKYRSPSRFSSECLDKIDSAKEN--NIVAVPRYATEVLRGSWNPLYIIINVW 554 N+ + +IRF + A YHNS+ R +++ + ++LIE G+ R++YG G++ FPS + W E + EVRQ++WL+ I++VP+R + D+ ++VEI + +R + F +E L +++ + N+VA P Y LR SW+P Y++IN W Sbjct: 12 NVGYYAVIRFGKDIAYNYHNSIKRIASIIQRSHNGQDCAFLPDVQLIE--GED------RRQYGYGLLYFPSFEAAKYWYECTNEVRQQDWLWSAAILLVPAR---GAFDKAMSVVEINDWSDFRDQTAFENEYLAELNDPSDGRWNVVACPDYLQYRLRSSWSPKYLVINQW 173
BLAST of XendoU domain-containing protein vs. TrEMBL
Match: A0A267DBP7 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002947g1 PE=4 SV=1) HSP 1 Score: 93.5893 bits (231), Expect = 9.488e-20 Identity = 55/173 (31.79%), Postives = 95/173 (54.91%), Query Frame = 3 Query: 45 NLPFLVLIRFQHNDAAAYHNSVIRQKPLLRTIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDEN-TIVEILEIVKYRSPSRFSSECLDKIDSAKEN--NIVAVPRYATEVLRGSWNPLYIIINVW 554 N+ + +IRF + A YHNS+ R +++ + ++LIE G+ R++YG G++ FPS + W E + EVRQ++WL+ I++VP+R + D+ ++VEI + +R + F +E L +++ + N+VA P Y LR SW+P Y++IN W Sbjct: 21 NVGYYAVIRFGKDIAYNYHNSIKRIASIIQRSHNGQDCAFLPDVQLIE--GED------RRQYGYGLLYFPSFEAAKYWYECTNEVRQQDWLWSAAILLVPAR---GAFDKAMSVVEINDWSDFRDQTAFENEYLAELNDPSDGRWNVVACPDYLQYRLRSSWSPKYLVINQW 182
BLAST of XendoU domain-containing protein vs. TrEMBL
Match: A0A1I8FH46 (XendoU domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 70.4774 bits (171), Expect = 2.177e-10 Identity = 45/147 (30.61%), Postives = 74/147 (50.34%), Query Frame = 3 Query: 45 NLPFLVLIRFQHNDAAAYHNSVIRQKPLLR---TIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDEN-TIVEILEIVKYRSPSRFSSECLDKIDSAKEN 473 N+ + +IRF + A YHNSV R +++ E L + R+E E R+ YG G++ FP+ + W E + EVRQ++WL+ DIVIVP+R + D+ ++EI + +R + F E L +++ E Sbjct: 432 NVGYYAVIRFTQDIAYNYHNSVKRTASIIQRSHGGHECAFLPDVQRIEGDE-----------RRLYGYGVLYFPNFDAAKYWYECTNEVRQQDWLWSADIVIVPAR---GAFDKGMAVLEINDWSAFRDQTAFEDEYLKGLNNTTEG 564
BLAST of XendoU domain-containing protein vs. Planmine SMEST
Match: SMESG000008612.1 (SMESG000008612.1) HSP 1 Score: 244.973 bits (624), Expect = 9.196e-84 Identity = 120/120 (100.00%), Postives = 120/120 (100.00%), Query Frame = 3 Query: 288 MSYEVRQKEWLFPVDIVIVPSRWRIKSIDENTIVEILEIVKYRSPSRFSSECLDKIDSAKENNIVAVPRYATEVLRGSWNPLYIIINVWSSDTEYNSNSHFALNDISDLVVGYSYIGHCY 647 MSYEVRQKEWLFPVDIVIVPSRWRIKSIDENTIVEILEIVKYRSPSRFSSECLDKIDSAKENNIVAVPRYATEVLRGSWNPLYIIINVWSSDTEYNSNSHFALNDISDLVVGYSYIGHCY Sbjct: 1 MSYEVRQKEWLFPVDIVIVPSRWRIKSIDENTIVEILEIVKYRSPSRFSSECLDKIDSAKENNIVAVPRYATEVLRGSWNPLYIIINVWSSDTEYNSNSHFALNDISDLVVGYSYIGHCY 120
BLAST of XendoU domain-containing protein vs. Planmine SMEST
Match: SMESG000069776.1 (SMESG000069776.1) HSP 1 Score: 97.4413 bits (241), Expect = 7.793e-25 Identity = 55/170 (32.35%), Postives = 92/170 (54.12%), Query Frame = 3 Query: 60 VLIRFQHNDAAAYHNSVIRQKPLLRTIFEALPLLTISRLELIEEIGKKSEFTIPRQRYGLGIIAFPSIGKIRDWLEMSYEVRQKEWLFPVDIVIVPSRWRIKSIDENT-IVEILEIVKYRSPSRFSSECLDKIDSAK--ENNIVAVPRYATEVLRGSWNPLYIIINVWSS 560 ++ F+ +DA +Y NS++RQ +L F + +++ IE T ++G+GII FP ++W E S+E+RQ +WL V +++VP+R +D IVE E +R +F +E L +++A +NNI+A P Y LRG+W P Y+ + W+S Sbjct: 14 LISHFKESDAYSYRNSIVRQITILERNFCGREVAFCQKMQPIE--------TNTENKFGIGIIHFPDFQIAKNWYESSHEIRQPDWLNNVTLILVPAR---NDVDFTMPIVEFAEWNFFRDVQKFQNEYLSHLNTADKGQNNIIAAPEYTYVKLRGNWCPKYLAVTQWAS 172 The following BLAST results are available for this feature:
BLAST of XendoU domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of XendoU domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of XendoU domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of XendoU domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of XendoU domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001357 ID=SMED30001357|Name=XendoU domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=677bpback to top protein sequence of SMED30001357-orf-1 >SMED30001357-orf-1 ID=SMED30001357-orf-1|Name=SMED30001357-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=208bp MSLFNSNLPFLVLIRFQHNDAAAYHNSVIRQKPLLRTIFEALPLLTISRLback to top Annotated Terms
The following terms have been associated with this transcript:
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