NCOA5

Overview
NameNCOA5 (AHA14850.1)
Smed IDSMED30001272
Length (bp)1207
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of NCOA5 (SMED30001272) t-SNE clustered cells

Violin plots show distribution of expression levels for NCOA5 (SMED30001272) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NCOA5 (SMED30001272) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NCOA5 (SMED30001272) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30001272

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30001272h1SMcG0003708 SmedASXL_011892SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30001272h1SMcG0003708 SmedASXL_011892SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001272h1SMcG0003708 dd_Smed_v4_2395_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30001272h1SMcG0003708 OX_Smed_1.0.03792ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of NCOA5 vs. Ensembl Human
Match: NCOA5 (nuclear receptor coactivator 5 [Source:HGNC Symbol;Acc:HGNC:15909])

HSP 1 Score: 58.9214 bits (141), Expect = 9.297e-9
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            +   ERP  D ++IV++ +   YAE++  R  R + +   +I L  E   +  +ED++  G  +A ++   ++ H SCT+ I++GTPQ
Sbjct:  191 RFDAERP-VDCSVIVVNKQTKDYAESV-GRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ 276
[Close]
BLAST of NCOA5 vs. Ensembl Human
Match: HNRNPC (heterogeneous nuclear ribonucleoprotein C [Source:HGNC Symbol;Acc:HGNC:5035])

HSP 1 Score: 54.299 bits (129), Expect = 2.068e-8
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. Ensembl Human
Match: HNRNPC (heterogeneous nuclear ribonucleoprotein C [Source:HGNC Symbol;Acc:HGNC:5035])

HSP 1 Score: 52.373 bits (124), Expect = 6.098e-8
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. Ensembl Human
Match: HNRNPC (heterogeneous nuclear ribonucleoprotein C [Source:HGNC Symbol;Acc:HGNC:5035])

HSP 1 Score: 52.373 bits (124), Expect = 7.198e-8
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. Ensembl Human
Match: HNRNPC (heterogeneous nuclear ribonucleoprotein C [Source:HGNC Symbol;Acc:HGNC:5035])

HSP 1 Score: 52.373 bits (124), Expect = 7.942e-8
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. Ensembl Fly
Match: Neos (gene:FBgn0024542 transcript:FBtr0333367)

HSP 1 Score: 49.6766 bits (117), Expect = 2.525e-6
Identity = 29/78 (37.18%), Postives = 44/78 (56.41%), Query Frame = -1 
Query:  233 DAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTP 466
            D  IIV + E   YAE IE RL+   +L   ++   E+      + +++++G LYA LV   +E+H S T+ ILYG P
Sbjct:  130 DCEIIVQNRENTKYAEYIEERLKNS-SLRVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVP 206
[Close]
BLAST of NCOA5 vs. Ensembl Fly
Match: Neos (gene:FBgn0024542 transcript:FBtr0076835)

HSP 1 Score: 49.6766 bits (117), Expect = 2.525e-6
Identity = 29/78 (37.18%), Postives = 44/78 (56.41%), Query Frame = -1 
Query:  233 DAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTP 466
            D  IIV + E   YAE IE RL+   +L   ++   E+      + +++++G LYA LV   +E+H S T+ ILYG P
Sbjct:  130 DCEIIVQNRENTKYAEYIEERLKNS-SLRVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVP 206
[Close]
BLAST of NCOA5 vs. Ensembl Zebrafish
Match: hnrnpc (heterogeneous nuclear ribonucleoprotein C [Source:ZFIN;Acc:ZDB-GENE-040426-2043])

HSP 1 Score: 60.077 bits (144), Expect = 1.266e-9
Identity = 28/73 (38.36%), Postives = 44/73 (60.27%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +QF +E +AR AV  E G+   G  +DV  A
Sbjct:   16 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGYAFVQFAQERNARTAVQGEDGRMVVGQVLDVNLA 88
[Close]
BLAST of NCOA5 vs. Ensembl Zebrafish
Match: hnrnpc (heterogeneous nuclear ribonucleoprotein C [Source:ZFIN;Acc:ZDB-GENE-040426-2043])

HSP 1 Score: 60.077 bits (144), Expect = 1.368e-9
Identity = 28/73 (38.36%), Postives = 44/73 (60.27%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +QF +E +AR AV  E G+   G  +DV  A
Sbjct:   23 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGYAFVQFAQERNARTAVQGEDGRMVVGQVLDVNLA 95
[Close]
BLAST of NCOA5 vs. Ensembl Zebrafish
Match: zgc:55733 (zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791])

HSP 1 Score: 56.6102 bits (135), Expect = 1.168e-8
Identity = 26/73 (35.62%), Postives = 44/73 (60.27%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +Q+  E +AR AV+ E G+   G  +D+  A
Sbjct:   23 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGFAFVQYANERNARAAVNGEDGRMIVGQVLDINLA 95
[Close]
BLAST of NCOA5 vs. Ensembl Zebrafish
Match: zgc:55733 (zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791])

HSP 1 Score: 56.225 bits (134), Expect = 1.886e-8
Identity = 26/73 (35.62%), Postives = 44/73 (60.27%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +Q+  E +AR AV+ E G+   G  +D+  A
Sbjct:   23 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGFAFVQYANERNARAAVNGEDGRMIVGQVLDINLA 95
[Close]
BLAST of NCOA5 vs. Ensembl Zebrafish
Match: zgc:55733 (zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791])

HSP 1 Score: 56.225 bits (134), Expect = 1.886e-8
Identity = 26/73 (35.62%), Postives = 44/73 (60.27%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +Q+  E +AR AV+ E G+   G  +D+  A
Sbjct:   23 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGFAFVQYANERNARAAVNGEDGRMIVGQVLDINLA 95
[Close]
BLAST of NCOA5 vs. Ensembl Xenopus
Match: ncoa5 (nuclear receptor coactivator 5 [Source:NCBI gene;Acc:394533])

HSP 1 Score: 59.6918 bits (143), Expect = 5.175e-9
Identity = 27/88 (30.68%), Postives = 49/88 (55.68%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            ++  ERP  D +++V++ +   YAE++  R  R + +   +I L  E      +ED+   G  +A ++   ++ H SCT+ IL+GTPQ
Sbjct:  211 RVDAERP-VDCSVVVVNKQSKEYAESV-GRKVRDLGMMVDLIFLNTEVSLTQALEDVTRGGSPFAIVITQQHQVHRSCTVNILFGTPQ 296
[Close]
BLAST of NCOA5 vs. Ensembl Xenopus
Match: ncoa5 (nuclear receptor coactivator 5 [Source:NCBI gene;Acc:394533])

HSP 1 Score: 59.3066 bits (142), Expect = 5.507e-9
Identity = 27/88 (30.68%), Postives = 49/88 (55.68%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            ++  ERP  D +++V++ +   YAE++  R  R + +   +I L  E      +ED+   G  +A ++   ++ H SCT+ IL+GTPQ
Sbjct:  201 RVDAERP-VDCSVVVVNKQSKEYAESV-GRKVRDLGMMVDLIFLNTEVSLTQALEDVTRGGSPFAIVITQQHQVHRSCTVNILFGTPQ 286
[Close]
BLAST of NCOA5 vs. Ensembl Xenopus
Match: RALY (RALY heterogeneous nuclear ribonucleoprotein [Source:NCBI gene;Acc:100497634])

HSP 1 Score: 54.6842 bits (130), Expect = 8.257e-8
Identity = 26/73 (35.62%), Postives = 41/73 (56.16%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   + +SD+    +K+G+V+   +    A +Q+  E  AR AV  E G+   G  +D+  A
Sbjct:   18 SLNSRVFIGNLNTAVVKKSDVESIFSKYGRVVGCSVHKGYAFVQYLNERHARGAVIGENGRVLAGQTLDINMA 90
[Close]
BLAST of NCOA5 vs. Ensembl Xenopus
Match: cers1 (ceramide synthase 1 [Source:Xenbase;Acc:XB-GENE-994751])

HSP 1 Score: 53.9138 bits (128), Expect = 1.570e-7
Identity = 24/74 (32.43%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + ++D+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   14 SMNSRVFIGNLNTLVVKKADVEAIFSKYGKIVGCSVHKGYAFVQYSNERNARTAVAGEDGRMIAGQVMDINLAA 87
[Close]
BLAST of NCOA5 vs. Ensembl Xenopus
Match: cers1 (ceramide synthase 1 [Source:Xenbase;Acc:XB-GENE-994751])

HSP 1 Score: 53.9138 bits (128), Expect = 1.584e-7
Identity = 24/74 (32.43%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + ++D+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   14 SMNSRVFIGNLNTLVVKKADVEAIFSKYGKIVGCSVHKGYAFVQYSNERNARTAVAGEDGRMIAGQVMDINLAA 87
[Close]
BLAST of NCOA5 vs. Ensembl Mouse
Match: Ncoa5 (nuclear receptor coactivator 5 [Source:MGI Symbol;Acc:MGI:2385165])

HSP 1 Score: 59.3066 bits (142), Expect = 3.273e-9
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            +   ERP  D ++IV++ +   YAE++  R  R + +   +I L  E   +  +ED++  G  +A ++   ++ H SCT+ I++GTPQ
Sbjct:  191 RFDAERP-VDCSVIVVNKQTKDYAESV-GRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ 276
[Close]
BLAST of NCOA5 vs. Ensembl Mouse
Match: Ncoa5 (nuclear receptor coactivator 5 [Source:MGI Symbol;Acc:MGI:2385165])

HSP 1 Score: 58.5362 bits (140), Expect = 7.817e-9
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            +   ERP  D ++IV++ +   YAE++  R  R + +   +I L  E   +  +ED++  G  +A ++   ++ H SCT+ I++GTPQ
Sbjct:  191 RFDAERP-VDCSVIVVNKQTKDYAESV-GRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ 276
[Close]
BLAST of NCOA5 vs. Ensembl Mouse
Match: Hnrnpc (heterogeneous nuclear ribonucleoprotein C [Source:MGI Symbol;Acc:MGI:107795])

HSP 1 Score: 52.373 bits (124), Expect = 4.186e-8
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. Ensembl Mouse
Match: Ralyl (RALY RNA binding protein-like [Source:MGI Symbol;Acc:MGI:1924147])

HSP 1 Score: 51.9878 bits (123), Expect = 1.451e-7
Identity = 30/95 (31.58%), Postives = 47/95 (49.47%), Query Frame = -1 
Query:  788 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPL 1072
            ++ SRV+IGNLN   + + DI    +K+GK++   +    A +Q+  E  AR AV  E  +   G  +D+  A       E +   P+  S RPL
Sbjct:   32 SINSRVFIGNLNTAIVKKVDIEAIFSKYGKIVGCSVHKGYAFVQYMSERHARAAVAGENARVIAGQPLDINMAG------EPKPYRPKPGSKRPL 120
[Close]
BLAST of NCOA5 vs. Ensembl Mouse
Match: Raly (hnRNP-associated with lethal yellow [Source:MGI Symbol;Acc:MGI:97850])

HSP 1 Score: 51.2174 bits (121), Expect = 1.697e-7
Identity = 25/74 (33.78%), Postives = 40/74 (54.05%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+G+V    +    A +Q+  E  AR AV  E G+   G  +D+  A 
Sbjct:   18 SINSRVFIGNLNTAVVKKSDVETIFSKYGRVAGCSVHKGYAFVQYANERHARAAVLGENGRVLAGQTLDINMAG 91
[Close]
BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q9HCD5|NCOA5_HUMAN (Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2)

HSP 1 Score: 58.9214 bits (141), Expect = 4.465e-8
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            +   ERP  D ++IV++ +   YAE++  R  R + +   +I L  E   +  +ED++  G  +A ++   ++ H SCT+ I++GTPQ
Sbjct:  191 RFDAERP-VDCSVIVVNKQTKDYAESV-GRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ 276
[Close]
BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q91W39|NCOA5_MOUSE (Nuclear receptor coactivator 5 OS=Mus musculus OX=10090 GN=Ncoa5 PE=1 SV=1)

HSP 1 Score: 58.5362 bits (140), Expect = 5.468e-8
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = -1 
Query:  230 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 493
            +   ERP  D ++IV++ +   YAE++  R  R + +   +I L  E   +  +ED++  G  +A ++   ++ H SCT+ I++GTPQ
Sbjct:  191 RFDAERP-VDCSVIVVNKQTKDYAESV-GRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ 276
[Close]
BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|P19600|HNRPC_XENLA (Heterogeneous nuclear ribonucleoprotein C OS=Xenopus laevis OX=8355 GN=hnrnpc PE=2 SV=1)

HSP 1 Score: 53.5286 bits (127), Expect = 1.047e-6
Identity = 25/74 (33.78%), Postives = 42/74 (56.76%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + ++D+    +K+GK++   +    A +QF  E  AR AV  E G+   G  +D+  A+
Sbjct:   14 SMNSRVFIGNLNTLVVKKTDVEAIFSKYGKIVGCSVHKGFAFVQFSNERTARTAVAGEDGRMIAGQVLDINLAA 87
[Close]
BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q9Z204|HNRPC_MOUSE (Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Mus musculus OX=10090 GN=Hnrnpc PE=1 SV=1)

HSP 1 Score: 52.7582 bits (125), Expect = 2.601e-6
Identity = 25/74 (33.78%), Postives = 43/74 (58.11%), Query Frame = -1 
Query:  851 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAS 1072
            ++ SRV+IGNLN   + +SD+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A+
Sbjct:   13 SMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAA 86
[Close]
BLAST of NCOA5 vs. UniProt/SwissProt
Match: sp|Q9UKM9|RALY_HUMAN (RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1)

HSP 1 Score: 52.373 bits (124), Expect = 2.804e-6
Identity = 25/73 (34.25%), Postives = 40/73 (54.79%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            ++ SRV+IGNLN   + +SD+    +K+G+V    +    A +Q+  E  AR AV  E G+   G  +D+  A
Sbjct:   18 SINSRVFIGNLNTALVKKSDVETIFSKYGRVAGCSVHKGYAFVQYSNERHARAAVLGENGRVLAGQTLDINMA 90
[Close]
BLAST of NCOA5 vs. TrEMBL
Match: U6A492 (NCOA5 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 531.561 bits (1368), Expect = 0.000e+0
Identity = 257/257 (100.00%), Postives = 257/257 (100.00%), Query Frame = -1 
Query:  230 MNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1000
            MNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ
Sbjct:    1 MNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 257
[Close]
BLAST of NCOA5 vs. TrEMBL
Match: A0A5K4EJD3 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 113.235 bits (282), Expect = 9.839e-25
Identity = 95/315 (30.16%), Postives = 144/315 (45.71%), Query Frame = -1 
Query:  230 GREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSR--------------SQLHQDYPVIP--KEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIAL-----TTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1111
            G  ++ P  +E S L  +V I +L  + I+ +DI +W+ K+G + +++I  R  L+QF+ + +A  AV  E G S  G ++ ++    SD     R+  P +R    L  +R S      R S RDR   DRE+   +L R       + P+N  +R  SP   R++ RS  I    R                 +L+    + P  K  +EP   SPP+             AII +  +L+ YAE IE R+ + +        THI+VL    H + C+ DL   GV +A +    N  H SCTLRILY   Q
Sbjct:    2 GTRDKSP--TESSCLVGKVLIEDLPKRAISHNDIRDWLKKYGCISEIVIYPRCLLVQFDSDIEAAGAVHCENGASLFGTKVSLKHVEASDLKALRRAGPPIDRFSTNL--QRHSG-----RVSSRDR---DREKSRGSLHRDHFRGRTKSPDNKRSRDISP---RRHSRSPVITRTDRRTVHPLNWLSEVAERDKKLNGSSLLGPANKSTEEPIVKSPPYM-----------VAIITVQHDLVPYAEIIEQRVTKTLTTPGSPSVTHIVVLLSVDHLSPCLADLTKDGVPFAIICTMTNWAHNSCTLRILYAPTQ 290
[Close]
BLAST of NCOA5 vs. TrEMBL
Match: A0A183JFN1 (RRM domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS1499 PE=4 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 1.912e-24
Identity = 89/289 (30.80%), Postives = 133/289 (46.02%), Query Frame = -1 
Query:  230 STLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIP--KEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIAL-----TTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1075
            S L  +V I +L  + I+ +DI +W+ K+G + +++I  R  L+QF+ + +A  AV  E G S  G ++ ++     D     R+  P +R    L     S        SGRDR   DR++   +LRR          +    R  SPD+     RSR I     SRS ++    + P  K  ++P   SPP+             AII +  +L+ YAE IE R+ + +        THI+VL    H + C+ DL   GV +A +    N  H SCTLRILY   Q
Sbjct:   12 SCLVGKVLIEDLPKRAISHNDIRDWLKKYGCISEIVIYPRCLLVQFDSDIEAAGAVQCENGASLFGTKVSLKHVEAGDLKALRRAGPPIDRFSTNLQRSFGSI-------SGRDR---DRDKSRGSLRR----------DRFRGRTKSPDN----KRSREISPRRHSRSPINGSSLLGPADKSTEKPIVKSPPYM-----------VAIITVQHDLVPYAEIIEQRVTKSLTTPGSPSVTHIVVLLSVDHLSPCLADLTKDGVPFAIICTMTNWAHNSCTLRILYAPTQ 265
[Close]
BLAST of NCOA5 vs. TrEMBL
Match: A0A183Q8R8 (RRM domain-containing protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 3.045e-24
Identity = 95/315 (30.16%), Postives = 145/315 (46.03%), Query Frame = -1 
Query:  230 GREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSR--------------SQLHQDYPVIP--KEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIAL-----TTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1111
            G  ++ P  +E S L  +V I +L  + I+ +DI +W+ K+G + +++I  R  L+QF+ + +A  AV  E G S  G ++ ++    SD     R+  P +R    L  +R S      R S RDR   DR++   +LRR       + P+N  +R  SP   R++ RS  I    R                 +L+    + P  K  +EP   SPP+             AII +  +L+ YAE IE R+ + +        THI+VL    H + C+ DL   GV +A +    N  H SCTLRILY   Q
Sbjct:    2 GTRDKSP--TESSCLVGKVLIEDLPKRAISHNDIRDWLKKYGCISEIVIYPRCLLVQFDSDIEAAGAVQCENGASLFGTKVSLKHVEASDLKALRRTGPPIDRFSTNL--QRHSG-----RVSSRDR---DRDKSRGSLRRDRFRGRTKSPDNKRSRDISP---RRHSRSPVITRTDRRTVHPLNWLSEVAERDKKLNGSSLLGPANKSTEEPIVKSPPYM-----------VAIITVQHDLVPYAEIIEQRVTKTLTTPGSPSVTHIVVLLSVDHLSPCLADLTKDGVPFAIICTMTNWAHNSCTLRILYAPTQ 290
[Close]
BLAST of NCOA5 vs. TrEMBL
Match: A0A430Q8J5 (RRM domain-containing protein OS=Schistosoma bovis OX=6184 GN=DC041_0002820 PE=4 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 3.138e-23
Identity = 91/301 (30.23%), Postives = 140/301 (46.51%), Query Frame = -1 
Query:  230 GREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIP--KEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIAL-----TTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1111
            G  ++ P  S  S L  +V I +L  + I+ +DI +W+ K+G + +++I  R  L+QF+ + +A  AV  E G S  G ++ ++     D     R+  P +R    L  +R    +     SGRDR   DR++   +LRR          +    R  SPD+     RSR +     SRS ++    + P  K  ++P   SPP+             AII +  +L+ YAE IE R+ + +        THI+VL    H + C+ DL   GV +A +    N  H SCTLRILY   Q
Sbjct:    2 GTRDKSPTGS--SCLVGKVLIEDLPKRAISHNDIRDWLKKYGCISEIVIYPRCLLVQFDSDIEAAGAVQCENGASLFGTKVSLKHVEAGDLKALRRAGPPIDRFSTNL--QRSFGSI-----SGRDR---DRDKSRGSLRR----------DRFRGRTKSPDN----KRSREVSPRRHSRSPINGSSLLGPADKSTEKPIVKSPPYM-----------VAIITVQHDLVPYAEIIEQRVTKSLTTPGSPSVTHIVVLLSVDHLSPCLADLTKDGVPFAIICTMTNWAHNSCTLRILYAPTQ 265
[Close]
BLAST of NCOA5 vs. Ensembl Cavefish
Match: zgc:55733 (zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791])

HSP 1 Score: 56.6102 bits (135), Expect = 1.142e-8
Identity = 26/73 (35.62%), Postives = 43/73 (58.90%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +D+  A
Sbjct:   23 SLNSRVFIGNLNTMLVTKADVEAIFSKYGKIVGCSVHKGYAFVQYANERNARAAVGGEDGRMIVGQVLDINLA 95
[Close]
BLAST of NCOA5 vs. Ensembl Cavefish
Match: ncoa5 (nuclear receptor coactivator 5 [Source:ZFIN;Acc:ZDB-GENE-040912-155])

HSP 1 Score: 53.5286 bits (127), Expect = 2.180e-7
Identity = 28/85 (32.94%), Postives = 46/85 (54.12%), Query Frame = -1 
Query:  230 TERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 484
             ERP  D ++IV++     YAET+  R  R + +   +I L  E      +ED++     +A ++   ++ H SCT+ IL+GTPQ
Sbjct:  100 AERP-VDCSVIVVNKLQKEYAETV-GRKVRDLGMVVDLIFLNTEVSLTQALEDVSRARTPFAIIITQQHQVHRSCTVNILFGTPQ 182
[Close]
BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000055457.1 (RALY RNA binding protein like [Source:NCBI gene;Acc:103047438])

HSP 1 Score: 52.373 bits (124), Expect = 2.428e-7
Identity = 31/95 (32.63%), Postives = 48/95 (50.53%), Query Frame = -1 
Query:  788 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPL 1072
            +L SRV+IGNLN   + ++DI     K+GK++   +    A +Q+  E +AR AV  E  +   G  +D+  A       E +   P+  S RPL
Sbjct:   18 SLNSRVFIGNLNTAIVKKTDIEVIFAKYGKIVGCSVHKGYAFVQYMSERNARAAVAGENARIIAGQPLDINMAG------EPKPYRPKPGSKRPL 106
[Close]
BLAST of NCOA5 vs. Ensembl Cavefish
Match: ENSAMXT00000019596.2 (RALY RNA binding protein like [Source:NCBI gene;Acc:103047438])

HSP 1 Score: 52.373 bits (124), Expect = 2.849e-7
Identity = 31/95 (32.63%), Postives = 48/95 (50.53%), Query Frame = -1 
Query:  788 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPL 1072
            +L SRV+IGNLN   + ++DI     K+GK++   +    A +Q+  E +AR AV  E  +   G  +D+  A       E +   P+  S RPL
Sbjct:   18 SLNSRVFIGNLNTAIVKKTDIEVIFAKYGKIVGCSVHKGYAFVQYMSERNARAAVAGENARIIAGQPLDINMAG------EPKPYRPKPGSKRPL 106
[Close]
BLAST of NCOA5 vs. Ensembl Cavefish
Match: ralyl (RNA-binding Raly-like protein [Source:NCBI gene;Acc:103026935])

HSP 1 Score: 50.447 bits (119), Expect = 1.168e-6
Identity = 32/95 (33.68%), Postives = 46/95 (48.42%), Query Frame = -1 
Query:  788 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPL 1072
            +L SRV+IGNLN   + +SDI     K+GK+    +    A +Q+  E +AR AV  E  +   G  +D+  A       E R   P+    RPL
Sbjct:   18 SLHSRVFIGNLNTTVVKKSDIELIFAKYGKITGCSVHKGFAFVQYASERNARSAVAGENARVIAGQPLDINMAG------EHRLYRPKVGLKRPL 106
[Close]
BLAST of NCOA5 vs. Ensembl Sea Lamprey
Match: hnrnpc (heterogeneous nuclear ribonucleoprotein C [Source:ZFIN;Acc:ZDB-GENE-040426-2043])

HSP 1 Score: 53.9138 bits (128), Expect = 1.226e-8
Identity = 28/95 (29.47%), Postives = 47/95 (49.47%), Query Frame = -1 
Query:  788 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPL 1072
            ++ SRV+IGNLN   + + D+    +K+GKV+   +      +Q+  E  AR AV  E G+   G ++D+  A       E +   P+    RP+
Sbjct:   18 SINSRVFIGNLNTAIVKKPDVETLFSKYGKVVGCSVHKGYGFVQYASERSARLAVAGENGRVMAGQQLDINMAG------EPKPNRPKTSGKRPV 106
[Close]
BLAST of NCOA5 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008870.1 (pep scaffold:Pmarinus_7.0:GL479376:31946:33501:1 gene:ENSPMAG00000008028.1 transcript:ENSPMAT00000008870.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 45.0542 bits (105), Expect = 8.229e-6
Identity = 27/85 (31.76%), Postives = 47/85 (55.29%), Query Frame = -1 
Query:  239 KIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYG 493
            K+  ERP  D  ++V +  L +YAE++  ++Q  + L+  +I LK E      +ED+   G  +   V+  +E + SCT+ IL+G
Sbjct:   30 KLERERP-VDCVVVVTNKTLKAYAESLGCQVQ-GLGLSVDLIFLKTEKSLVEAMEDVRKSGTPFIITVSQQHELYKSCTVIILHG 112
[Close]
BLAST of NCOA5 vs. Ensembl Yeast
Match: NAB3 (RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability [Source:SGD;Acc:S000006111])

HSP 1 Score: 47.7506 bits (112), Expect = 2.234e-6
Identity = 22/84 (26.19%), Postives = 48/84 (57.14%), Query Frame = -1 
Query:  845 RISEMSTLA--SRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTS 1090
            +I+EM  +   SR++IGNL  KN+++ D++   + +G ++ + I +    IQF+     R A++ E  +   G ++ +  +S++
Sbjct:  319 KITEMHNIPPKSRLFIGNLPLKNVSKEDLFRIFSPYGHIMQINIKNAFGFIQFDNPQSVRDAIECESQEMNFGKKLILEVSSSN 402
[Close]
BLAST of NCOA5 vs. Ensembl Nematostella
Match: EDO36698 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHW7])

HSP 1 Score: 49.6766 bits (117), Expect = 6.252e-8
Identity = 24/64 (37.50%), Postives = 35/64 (54.69%), Query Frame = -1 
Query:  869 RVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRI 1060
            R++IGNL    I R D+ E  ++HGKV+   +      +QFE E  A  AV +E G+   G +I
Sbjct:   19 RIFIGNLATDKIARQDLEEIFSRHGKVLGCSLHANFGFVQFETEKGADEAVAKEHGRIINGKKI 82
[Close]
BLAST of NCOA5 vs. Ensembl Medaka
Match: ncoa5 (nuclear receptor coactivator 5 [Source:NCBI gene;Acc:101172651])

HSP 1 Score: 80.8777 bits (198), Expect = 4.362e-16
Identity = 92/340 (27.06%), Postives = 147/340 (43.24%), Query Frame = -1 
Query:  230 RLRDADYGREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA-------STSDGSFESR---SEIPRNRSPRPLPYERDS---RDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEE-PRSRSQLHQDYPVIPKEIQEPKWNS---PPFTDKI----------------------GTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1132
            R R    GR  R    ++   L  R+++GNL   ++ + D+ +  + +GK+I V +      +QFER  +A  A   +KG+ ++G +IDV  A         S  S   R   S+ PR RS  P+ Y RD    RD    RDSGR+  P+   R      R   S+  +   +  +   S + Y +Y RS    E+  R +   ++D    P       WN    P  TD++                       T+RP   + I+V  ++   YAET+  R  R + +   +I L  E      +ED+      +A ++   ++ H SCT+ IL+GTPQ
Sbjct:    5 RSRSPSPGRFSRTCSSNDPRDLERRIFVGNLPTSDMEKKDLEDLFSPYGKIIGVSLFRGYGFVQFERVEEAEAARAAQKGRLYKGYKIDVNMAVERRQAKPLSQQSPPRRAPYSKDPRPRSRSPV-YGRDGREPRDSRDARDSGREPRPSSHSRDPDYRYRSSESRDKDLRADPRDPAYSREDYDRYYRSSSAAEDYYRRKDDAYRDPYADP-------WNGRRDPGVTDRVRPEERRRNELYRQYYEELQRRYDTDRPVDCSVIVVNKAQNREYAETV-GRKVRDLGMVVDLIFLNTEVSLTQALEDVGRARTPFAIIITQQHQVHRSCTVNILFGTPQ 335
[Close]
BLAST of NCOA5 vs. Ensembl Medaka
Match: ralyl (RNA-binding Raly-like protein [Source:NCBI gene;Acc:101165260])

HSP 1 Score: 58.9214 bits (141), Expect = 2.234e-9
Identity = 35/109 (32.11%), Postives = 54/109 (49.54%), Query Frame = -1 
Query:  746 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRD 1072
            +L SRV+IGNLN   ++++DI     K+GK++   +    A +Q+  E +AR AVD E  +   G  +D+  A       E +   P+  S RPL       +   YRD
Sbjct:   18 SLNSRVFIGNLNTAVVSKADIEAIFAKYGKIVGCSVHKGYAFVQYVSERNARAAVDGENARVIAGQPLDINMAG------EPKPYRPKISSKRPLSSLYSGYEFDYYRD 120
[Close]
BLAST of NCOA5 vs. Ensembl Medaka
Match: ralyl (RNA-binding Raly-like protein [Source:NCBI gene;Acc:101165260])

HSP 1 Score: 58.9214 bits (141), Expect = 2.234e-9
Identity = 35/109 (32.11%), Postives = 54/109 (49.54%), Query Frame = -1 
Query:  746 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRD 1072
            +L SRV+IGNLN   ++++DI     K+GK++   +    A +Q+  E +AR AVD E  +   G  +D+  A       E +   P+  S RPL       +   YRD
Sbjct:   18 SLNSRVFIGNLNTAVVSKADIEAIFAKYGKIVGCSVHKGYAFVQYVSERNARAAVDGENARVIAGQPLDINMAG------EPKPYRPKISSKRPLSSLYSGYEFDYYRD 120
[Close]
BLAST of NCOA5 vs. Ensembl Medaka
Match: ENSORLT00000012549.2 (heterogeneous nuclear ribonucleoprotein C [Source:NCBI gene;Acc:101163114])

HSP 1 Score: 56.225 bits (134), Expect = 1.790e-8
Identity = 26/73 (35.62%), Postives = 43/73 (58.90%), Query Frame = -1 
Query:  854 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFA 1072
            +L SRV++GNLN   +T++D+    +K+GKV+   +    A +Q+  E +AR AV  E G+   G  +D+  A
Sbjct:   25 SLNSRVFVGNLNTLLVTKADVEAIFSKYGKVVGCSVHKGYAFVQYLNERNARAAVGGEDGRVLAGQALDINLA 97
[Close]
BLAST of NCOA5 vs. Ensembl Medaka
Match: ENSORLT00000003915.2 (heterogeneous nuclear ribonucleoprotein C [Source:NCBI gene;Acc:101167735])

HSP 1 Score: 55.4546 bits (132), Expect = 3.643e-8
Identity = 26/75 (34.67%), Postives = 44/75 (58.67%), Query Frame = -1 
Query:  848 TLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAST 1072
            +L SRV+IGNLN   +T++D+    +K+GK++   +    A +Q+  E +AR AV  E G+   G  +DV   ++
Sbjct:   24 SLNSRVFIGNLNTLLVTKTDVEAIFSKYGKIVGCSVHKGYAFVQYANERNARAAVAGEDGRMIVGQVLDVAMCAS 98
[Close]
BLAST of NCOA5 vs. Planmine SMEST
Match: SMESG000010804.1 (SMESG000010804.1)

HSP 1 Score: 630.172 bits (1624), Expect = 0.000e+0
Identity = 306/306 (100.00%), Postives = 306/306 (100.00%), Query Frame = -1 
Query:  230 MSRSNRLRDADYGREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 1147
            MSRSNRLRDADYGREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ
Sbjct:    1 MSRSNRLRDADYGREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWMNKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFASTSDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKALRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYPVIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQRQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRILYGTPQ 306
The following BLAST results are available for this feature:
BLAST of NCOA5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NCOA59.297e-930.68nuclear receptor coactivator 5 [Source:HGNC Symbol... [more]
HNRNPC2.068e-833.78heterogeneous nuclear ribonucleoprotein C [Source:... [more]
HNRNPC6.098e-833.78heterogeneous nuclear ribonucleoprotein C [Source:... [more]
HNRNPC7.198e-833.78heterogeneous nuclear ribonucleoprotein C [Source:... [more]
HNRNPC7.942e-833.78heterogeneous nuclear ribonucleoprotein C [Source:... [more]
back to top
BLAST of NCOA5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of NCOA5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Neos2.525e-637.18gene:FBgn0024542 transcript:FBtr0333367[more]
Neos2.525e-637.18gene:FBgn0024542 transcript:FBtr0076835[more]
back to top
BLAST of NCOA5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hnrnpc1.266e-938.36heterogeneous nuclear ribonucleoprotein C [Source:... [more]
hnrnpc1.368e-938.36heterogeneous nuclear ribonucleoprotein C [Source:... [more]
zgc:557331.168e-835.62zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791][more]
zgc:557331.886e-835.62zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791][more]
zgc:557331.886e-835.62zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791][more]
back to top
BLAST of NCOA5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ncoa55.175e-930.68nuclear receptor coactivator 5 [Source:NCBI gene;A... [more]
ncoa55.507e-930.68nuclear receptor coactivator 5 [Source:NCBI gene;A... [more]
RALY8.257e-835.62RALY heterogeneous nuclear ribonucleoprotein [Sour... [more]
cers11.570e-732.43ceramide synthase 1 [Source:Xenbase;Acc:XB-GENE-99... [more]
cers11.584e-732.43ceramide synthase 1 [Source:Xenbase;Acc:XB-GENE-99... [more]
back to top
BLAST of NCOA5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ncoa53.273e-930.68nuclear receptor coactivator 5 [Source:MGI Symbol;... [more]
Ncoa57.817e-930.68nuclear receptor coactivator 5 [Source:MGI Symbol;... [more]
Hnrnpc4.186e-833.78heterogeneous nuclear ribonucleoprotein C [Source:... [more]
Ralyl1.451e-731.58RALY RNA binding protein-like [Source:MGI Symbol;A... [more]
Raly1.697e-733.78hnRNP-associated with lethal yellow [Source:MGI Sy... [more]
back to top
BLAST of NCOA5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9HCD5|NCOA5_HUMAN4.465e-830.68Nuclear receptor coactivator 5 OS=Homo sapiens OX=... [more]
sp|Q91W39|NCOA5_MOUSE5.468e-830.68Nuclear receptor coactivator 5 OS=Mus musculus OX=... [more]
sp|P19600|HNRPC_XENLA1.047e-633.78Heterogeneous nuclear ribonucleoprotein C OS=Xenop... [more]
sp|Q9Z204|HNRPC_MOUSE2.601e-633.78Heterogeneous nuclear ribonucleoproteins C1/C2 OS=... [more]
sp|Q9UKM9|RALY_HUMAN2.804e-634.25RNA-binding protein Raly OS=Homo sapiens OX=9606 G... [more]
back to top
BLAST of NCOA5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
U6A4920.000e+0100.00NCOA5 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A5K4EJD39.839e-2530.16Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A183JFN11.912e-2430.80RRM domain-containing protein OS=Schistosoma curas... [more]
A0A183Q8R83.045e-2430.16RRM domain-containing protein OS=Schistosoma rodha... [more]
A0A430Q8J53.138e-2330.23RRM domain-containing protein OS=Schistosoma bovis... [more]
back to top
BLAST of NCOA5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
zgc:557331.142e-835.62zgc:55733 [Source:ZFIN;Acc:ZDB-GENE-040426-791][more]
ncoa52.180e-732.94nuclear receptor coactivator 5 [Source:ZFIN;Acc:ZD... [more]
ENSAMXT00000055457.12.428e-732.63RALY RNA binding protein like [Source:NCBI gene;Ac... [more]
ENSAMXT00000019596.22.849e-732.63RALY RNA binding protein like [Source:NCBI gene;Ac... [more]
ralyl1.168e-633.68RNA-binding Raly-like protein [Source:NCBI gene;Ac... [more]
back to top
BLAST of NCOA5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hnrnpc1.226e-829.47heterogeneous nuclear ribonucleoprotein C [Source:... [more]
ENSPMAT00000008870.18.229e-631.76pep scaffold:Pmarinus_7.0:GL479376:31946:33501:1 g... [more]
back to top
BLAST of NCOA5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
NAB32.234e-626.19RNA-binding protein, subunit of Nrd1 complex (Nrd1... [more]
back to top
BLAST of NCOA5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO366986.252e-837.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of NCOA5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ncoa54.362e-1627.06nuclear receptor coactivator 5 [Source:NCBI gene;A... [more]
ralyl2.234e-932.11RNA-binding Raly-like protein [Source:NCBI gene;Ac... [more]
ralyl2.234e-932.11RNA-binding Raly-like protein [Source:NCBI gene;Ac... [more]
ENSORLT00000012549.21.790e-835.62heterogeneous nuclear ribonucleoprotein C [Source:... [more]
ENSORLT00000003915.23.643e-834.67heterogeneous nuclear ribonucleoprotein C [Source:... [more]
back to top
BLAST of NCOA5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000010804.10.000e+0100.00SMESG000010804.1[more]
back to top
Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30001272
GenBankAHA14850.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001272 ID=SMED30001272|Name=NCOA5|organism=Schmidtea mediterranea sexual|type=transcript|length=1207bp
GTTAAGCTAAAAATTCAAATTTAATTTTAATTAAGTTGAACATCAGAATA
TTCAAGAATTTACTCCATTAAGTCGAGAATAAAATTCAGATTACGCTTTT
CATTCGATCCTCAAAAACCGTTCAATTTTCCAACAAGTTCAATTGTTATC
CCATATGAGTGACATAGATAAATTTATCTAGTACAAACTTCCACATTTAA
TTCGATTTGCACTAGTTTTCAAATAAAGCCTGAGGAGTACCATATAAGAT
TCTTAAAGTACAGCTGAAGTGTTGCTCATTGAGGCTATTAACCAAAAATG
CGTATAGTACACCTTTGTTATTTAGGTCTTCGACGCATGCGTTTGCATGT
GACTCTTCCTTTAAAACTATTATATGAGTTGTCAATGCAATTTGTCTTTG
TAAGCGTGACTCTATGGTTTCCGCATAACTTAACAGCTCACTTGACATAA
CTATTATTGCTGCATCAAAACCAGGCCTTTCTGTTCCAATTTTATCAGTA
AATGGTGGAGAATTCCACTTGGGTTCTTGAATCTCTTTTGGAATTACTGG
ATAGTCTTGGTGAAGTTGAGATCTTGATCTTGGTTCTTCAACAATGCCTC
GAGATCTATCGTATTTTCTATATGAATCAGGTGATCCATGACGATTATTG
AGATTTTCGGGTTCCTCTATAATTTTGCTGGAATCACCTCGGCGTAATGC
TTTGTAGTATCTTTCTCTATCAGCAGGTGACCTATCCCTTCCAGAATCTC
TGTACGGTGACATATCACGAGAATCACGTTCGTATGGTAATGGCCGTGGA
CTTCTATTCCTTGGAATTTCTGATCTAGATTCAAATGAACCGTCGGATGT
AGATGCAAACCTAACATCTATTCTATTTCCCCTGAAACTCTGACCTTTTT
CTCTATCGACAGCTCTGCGAGCATCGCCTTCCCTTTCAAATTGAATTAAT
GCTTGTCGGTCTGAGATCATAACATCAATAACTTTTCCATGTTTATTCAT
CCATTCATAAATATCACTGCGAGTTATATTTTTAAAATTAAGATTGCCTA
TATACACTCTAGAAGCCAGAGTGCTCATTTCAGATATTCTAGGTCTTCTT
TCTTCCCTGCCATAATCAGCGTCACGTAATCTATTACTTCTGCTCATTTT
CAATTAACACAATAAAGGATTAAATAATATGTCTGCTGTTTGTAGATTGC
AGTTAAT
back to top

protein sequence of SMED30001272-orf-1

>SMED30001272-orf-1 ID=SMED30001272-orf-1|Name=SMED30001272-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=312bp
MSRSNRLRDADYGREERRPRISEMSTLASRVYIGNLNFKNITRSDIYEWM
NKHGKVIDVMISDRQALIQFEREGDARRAVDREKGQSFRGNRIDVRFAST
SDGSFESRSEIPRNRSPRPLPYERDSRDMSPYRDSGRDRSPADRERYYKA
LRRGDSSKIIEEPENLNNRHGSPDSYRKYDRSRGIVEEPRSRSQLHQDYP
VIPKEIQEPKWNSPPFTDKIGTERPGFDAAIIVMSSELLSYAETIESRLQ
RQIALTTHIIVLKEESHANACVEDLNNKGVLYAFLVNSLNEQHFSCTLRI
LYGTPQALFEN*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036621Anticodon-bd_dom_sf
IPR035979RBD_domain_sf
IPR000504RRM_dom
IPR012677Nucleotide-bd_a/b_plait_sf
IPR004154Anticodon-bd
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0000166nucleotide binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000504RNA recognition motif domainSMARTSM00360rrm1_1coord: 30..96
e-value: 1.5E-9
score: 47.7
IPR000504RNA recognition motif domainPFAMPF00076RRM_1coord: 31..93
e-value: 1.5E-9
score: 37.6
IPR000504RNA recognition motif domainPROSITEPS50102RRMcoord: 29..100
score: 13.447
IPR036621Anticodon-binding domain superfamilyGENE3DG3DSA:3.40.50.800coord: 220..309
e-value: 2.2E-22
score: 80.8
IPR012677Nucleotide-binding alpha-beta plait domain superfamilyGENE3DG3DSA:3.30.70.330coord: 24..108
e-value: 4.4E-16
score: 60.8
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 108..180
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 93..107
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 91..180
NoneNo IPR availablePANTHERPTHR23295NUCLEAR RECEPTOR COACTIVATOR 5-RELATEDcoord: 25..306
NoneNo IPR availableSUPERFAMILYSSF52954Class II aaRS ABD-relatedcoord: 228..308
IPR035979RNA-binding domain superfamilySUPERFAMILYSSF54928RNA-binding domain, RBDcoord: 24..102