Deoxyribonuclease II

Overview
NameDeoxyribonuclease II
Smed IDSMED30001221
Length (bp)1202
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Deoxyribonuclease II (SMED30001221) t-SNE clustered cells

Violin plots show distribution of expression levels for Deoxyribonuclease II (SMED30001221) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Deoxyribonuclease II (SMED30001221) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Deoxyribonuclease II (SMED30001221) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30001221

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
cephalic gangliaSMED30001221SMESG000081036.1 dd_Smed_v4_1199_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001221SMESG000081036.1 dd_Smed_v4_1199_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30001221SMESG000081036.1 dd_Smed_v6_1199_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875])

HSP 1 Score: 179.874 bits (455), Expect = 2.466e-52
Identity = 111/338 (32.84%), Postives = 169/338 (50.00%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYP-------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNK-DKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVI-HLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVE-INDVRDHSKWAVTLSNATSA-TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            A I C++E+   +DW+   K P       G     YL  ++   +W+     +N  K+++  TL Q Y A  +K + T Y  YND   K V+ S   GH KG++ ++   G+WLIHS+P FPP+   GY YP     NGQS IC++ K +    +  QLL+    VYS   P +F        ++ +L     S  I   ++  L +      +HF KS  F +D+++  +A +LK  L  E+W        PSNC L Y VYNIK +K+      +  +DH+KW ++     +  TCIGD+NR   Q +R GG +C  +  ++ AF   V  YE C+
Sbjct:   28 ATISCRNEEGKAVDWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSCSIPATFHQELI---HMPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKR-QELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK 361
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Human
Match: DNASE2 (deoxyribonuclease 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:2960])

HSP 1 Score: 154.066 bits (388), Expect = 1.524e-42
Identity = 105/342 (30.70%), Postives = 154/342 (45.03%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGV----------YNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDK---SKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV---RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI---LGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
              + C  +    +DW++  K P +            + YL   + G  W+     +NS +  V  +L   Y  ++N  +  +  YND     SK    S  GH KGV+  D + G+WL+HSVP+FPP      YS+P      GQ+ +CVS   +  + + KQL   Y  VY+Y     F        N+ +  H    P   S  I L + +      F K   F +DLYS  +A  L  +L V+ W +   G  PSNC   ++V N+  +      G   N   DHSKW V  S     TC+GD+NR + +  RGGG+LC     +W AF   V +Y+ C
Sbjct:   15 GALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGG--WRDGRALINSPEGAVGRSLQPLY--RSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSS--ITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFW-HKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCV--SPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPC 347
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875])

HSP 1 Score: 89.3521 bits (220), Expect = 1.275e-20
Identity = 47/134 (35.07%), Postives = 71/134 (52.99%), Query Frame = 3 
Query:  675 LNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVE-INDVRDHSKWAVTLSNATSA-TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            L +      +HF KS  F +D+++  +A +LK  L  E+W        PSNC L Y VYNIK +K+      +  +DH+KW ++     +  TCIGD+NR   Q +R GG +C  +  ++ AF   V  YE C+
Sbjct:   21 LQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETW-QRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK 153
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Match: crn-7 (Cell-death-related nuclease 7 [Source:UniProtKB/Swiss-Prot;Acc:P34387])

HSP 1 Score: 195.282 bits (495), Expect = 1.455e-58
Identity = 114/343 (33.24%), Postives = 172/343 (50.15%), Query Frame = 3 
Query:   75 AISFQQHLAKIMCKSEKNLDLDWYIAIKYPGV-------YNFFYLSSE----TNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            ++ F     KI CK+ +   +DW++  K P +         F Y  +E    T GN    PN A       V  T+SQ YSA  +K   F+  Y+DD     + S  GH KGV  FD  TG+WLIHSVP+FPP++ +SYP+     GQSF C S++   L ++ +    + A  Y    P  +        N+        S +       + T+  V L+ + K K F  D+++ LI+ Q K +L VESWLNG+G    + C  T + +++  +++ G+     +DHSKWAV+ S      C GD+NR +SQ  RGGG+LC  + N+W  ++  V   E C+
Sbjct:   10 SVIFTTGNGKIQCKNMRGKSVDWFVVYKLPKLSGAGTSGKEFVYFDAESSDWTRGNDINDPNVA-------VGATVSQVYSA--DKSNNFWFMYSDDDPIKSADSYRGHAKGVSLFDSTTGFWLIHSVPNFPPIKSFSYPNTAEKYGQSFFCASMEVQHLTELAEHWKYIQATPYIINIPEKYATRFPTLKNVEAKQSLPRSATQFWISKPIKTVQGVTLMAYAKHKKFDGDIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPCK 343
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Match: nuc-1 (Deoxyribonuclease-2 [Source:UniProtKB/Swiss-Prot;Acc:Q17778])

HSP 1 Score: 164.081 bits (414), Expect = 1.450e-46
Identity = 111/360 (30.83%), Postives = 164/360 (45.56%), Query Frame = 3 
Query:   78 ISFQQHLAKIMCKSEKNLDLDWYIAIKYP------------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDK--SKNVSG-----------------SND------GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIK-SNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILG-VEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFN 1040
            +   Q  A   CK +   D+DW+   K P            G   ++Y+     G T       L+ +   +A TL Q Y  +N+K   F+  YND+   SK+ SG                  +D      GH KG I FD  +G WL+HSVP FP    Y YP   H  GQ+ +C++ K + L  +  QL      +YS   P +  A+   + +L + +   +       +VI L T++     +F KSK F  DLY  L+AP LK  L VE+W  G+    P +C+LTY   +  ++ +      +  +DHSK A +        CIGDINRM SQ+ RGGG+ C     +W A++
Sbjct:   14 LGVSQTYAAFSCKDQSGNDVDWFAVYKMPIEKDDGSVTGLAGGVAWYYVDVNKKG-TLTPSAKTLDDNDQAIAYTLQQYYDKQNDK-TIFHVMYNDEPWGSKSTSGIKLEEILSNRVYSNYTHEDDSTSTAFGHTKGTIFFDGTSGVWLVHSVPLFPNPTKYEYPVSGHDYGQTMLCMTFKYAQLKSIGTQLFFNRPNIYSSNLPTNMAAD---NADLAKAIAGQYQKGQPFQSVIELETMAGYSFTNFAKSKEFNADLYDTLVAPTLKTDLVVETWRRGS--EIPLDCKLTYHANDALSIHVGSTTAFSYTKDHSKMAHSADMTKPWVCIGDINRMTSQYVRGGGTTCISSSFLWKAYS 366
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 161.384 bits (407), Expect = 1.407e-45
Identity = 108/347 (31.12%), Postives = 161/347 (46.40%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYN------------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGRE---PSNCQLTY--KVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSA-----TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A   CK     ++DW++  K P ++N            F Y   + N   WKL    ++ + N V  TL Q Y++  N + TF   YND+   +   SN  GH KGV  FD+ TG+W+IHS+P FP    + +P   H  GQ  IC+S  T  L  + +QL       Y +  P+SF     +   L    +N   P   + V  L ++      HF K+  +  DLYS  + P LK S+ VE+W N   G E   PS C   +     + K +++   ++ +   DHSK+ V  S ++S       CIGDINR   Q +RGGG++C      +  F   +S+   C
Sbjct:   17 AAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYF--DVNNKNWKLMPQGMDVENNAVYYTLQQYYNS--NMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKV--LKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETW-NHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPC 356
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 161.384 bits (407), Expect = 1.407e-45
Identity = 108/347 (31.12%), Postives = 161/347 (46.40%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYN------------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGRE---PSNCQLTY--KVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSA-----TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A   CK     ++DW++  K P ++N            F Y   + N   WKL    ++ + N V  TL Q Y++  N + TF   YND+   +   SN  GH KGV  FD+ TG+W+IHS+P FP    + +P   H  GQ  IC+S  T  L  + +QL       Y +  P+SF     +   L    +N   P   + V  L ++      HF K+  +  DLYS  + P LK S+ VE+W N   G E   PS C   +     + K +++   ++ +   DHSK+ V  S ++S       CIGDINR   Q +RGGG++C      +  F   +S+   C
Sbjct:   17 AAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYF--DVNNKNWKLMPQGMDVENNAVYYTLQQYYNS--NMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKV--LKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETW-NHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPC 356
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 161.384 bits (407), Expect = 1.412e-45
Identity = 108/347 (31.12%), Postives = 161/347 (46.40%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYN------------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGRE---PSNCQLTY--KVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSA-----TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A   CK     ++DW++  K P ++N            F Y   + N   WKL    ++ + N V  TL Q Y++  N + TF   YND+   +   SN  GH KGV  FD+ TG+W+IHS+P FP    + +P   H  GQ  IC+S  T  L  + +QL       Y +  P+SF     +   L    +N   P   + V  L ++      HF K+  +  DLYS  + P LK S+ VE+W N   G E   PS C   +     + K +++   ++ +   DHSK+ V  S ++S       CIGDINR   Q +RGGG++C      +  F   +S+   C
Sbjct:   17 AAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYF--DVNNKNWKLMPQGMDVENNAVYYTLQQYYNS--NMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKV--LKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETW-NHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPC 356
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Fly
Match: DNaseII (gene:FBgn0000477 transcript:FBtr0083538)

HSP 1 Score: 171.785 bits (434), Expect = 1.482e-49
Identity = 113/350 (32.29%), Postives = 174/350 (49.71%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNG-----------NTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSF-TANTTLDYNLGRLVHNM---HSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVK--ILGVEINDVRDHSKWAVTLSNAT----------SATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            +K+ CK E   D+DW+   K P  Y    L  +T+G           +TW++    ++   +L A TL+      ++   T  A YND +      S+ GH KGV+  D ET  W++HSVP FP +  YSYP       QS +CV++K  DL  V +  +L+Y   + YY      T +  L  +L R +H      SP  K   + + ++       FGKS     +LY+ ++AP L  SLFVE+W +G  G  P++C  + KV N++++    L V+    +DHSKWAV+                  C+GDINR E Q +RGGG++C     V + + + V++Y+KC
Sbjct:   21 SKVSCKDEAGNDVDWWHLYKLPKHYQHNDLGKDTSGLKYLYVTSQNYDTWQMSGKFISDPLSLPAQTLN---PLNDDPSHTLLAAYNDQQPNGTVFSSGGHAKGVVASDGETAIWIVHSVPKFPTIPDYSYPTSGEQYAQSMLCVTLKGEDLEKVGQ--ILVYNEPHFYYQRNPLATRSDELFPSLERALHGQWRTESPFQKD--LEVRSLDGKKFRLFGKSGRANVELYADVVAPTLDVSLFVEAWRDG-AGNLPNSCDKSDKVLNVESISNPELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGGGTVCHKSARVSNLYRQLVTNYDKC 362
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2])

HSP 1 Score: 163.696 bits (413), Expect = 1.143e-46
Identity = 112/346 (32.37%), Postives = 174/346 (50.29%), Query Frame = 3 
Query:   78 ISFQQHLAKIMCKSEKNLDLDWYIAIKYP---------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVH--NMHSPSIKS--NVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEI-NDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + FQ     I C +E    +DW+I  K P         GV ++ YL        +++  Y +NS    +  TL+Q YS   + + + Y  YND   +    S  GH KGV+ FD++ G+WL HSVPHFPP   R YSYP      GQ+ +C++   +    +  QL  +  RVY+   P +F        ++G +    +  +P+IK+  ++  L ++       F KS+ + +D+Y+  +A  L   L VESWL+    + PSNC L + V NI  V + G ++     DHSKW V+ +     TC+GD+NR   Q  RGGG  C  +  ++ AF KA++ Y+ C
Sbjct:    3 VLFQLSACLISCLNEDGQPVDWFIMYKLPIYKMEVKGSGV-DYMYLDPSIMD--FQISKYTVNSSTGALGRTLTQLYSGYTS-NSSVYMLYNDAPPELKYPSKYGHTKGVLMFDQDQGFWLTHSVPHFPPFPERNYSYPLTGKYYGQTLLCITFNYTQFPRISWQLAYLNPRVYNCSVPVAFRP------DIGEMAQICDGKTPAIKNRRSLQKLQSVQGQTFFSFAKSQNYVDDIYTGWVAQALGTDLLVESWLH-QAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 337
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2])

HSP 1 Score: 162.54 bits (410), Expect = 4.683e-46
Identity = 111/339 (32.74%), Postives = 172/339 (50.74%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYP---------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVH--NMHSPSIKS--NVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEI-NDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A I C +E    +DW+I  K P         GV ++ YL        +++  Y +NS    +  TL+Q YS   + + + Y  YND   +    S  GH KGV+ FD++ G+WL HSVPHFPP   R YSYP      GQ+ +C++   +    +  QL  +  RVY+   P +F        ++G +    +  +P+IK+  ++  L ++       F KS+ + +D+Y+  +A  L   L VESWL+    + PSNC L + V NI  V + G ++     DHSKW V+ +     TC+GD+NR   Q  RGGG  C  +  ++ AF KA++ Y+ C
Sbjct:   21 AVISCLNEDGQPVDWFIMYKLPIYKMEVKGSGV-DYMYLDPSIMD--FQISKYTVNSSTGALGRTLTQLYSGYTS-NSSVYMLYNDAPPELKYPSKYGHTKGVLMFDQDQGFWLTHSVPHFPPFPERNYSYPLTGKYYGQTLLCITFNYTQFPRISWQLAYLNPRVYNCSVPVAFRP------DIGEMAQICDGKTPAIKNRRSLQKLQSVQGQTFFSFAKSQNYVDDIYTGWVAQALGTDLLVESWLH-QAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 348
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 159.073 bits (401), Expect = 1.644e-44
Identity = 112/347 (32.28%), Postives = 165/347 (47.55%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIKYPGVYN--------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDD--KSKNVSGSND--GHLKGVINFDEETGYWLIHSVPHFPPVRG---YSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMH-----SPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSA--TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
             + I C +++   +DWY   K P  ++        + ++  E+ G  W      +N  ++ V  T+   Y   +      Y  YND   K K V G++   GH KGV+ FD+E G+WL+HS PHFPP +    +SYP     NGQ+FICV+        + +QL +    ++    P S          L +  H +      S S  +  I L +++K   I F K   FANDLY   +AP L+ +L V+ W     G  PS+C   ++V NI  +     V      DHSKWAV+ S+ TS    C+GDINR E++  RGGG++C     VW A+  A    E C
Sbjct:   16 FSSISCYNDQGKPVDWYYLYKLPHEHHTPLEEGLKYLFMDVESEG--WTDGTTLVNDTQSAVGRTVGPLYEGGD----VGYILYNDQPPKQKQVEGASRSCGHTKGVVVFDKEQGFWLVHSTPHFPPPKSEGQFSYPTSGISNGQNFICVTYPFERFQTIGEQLKINQPHIFDCSIPGSLATAVPAMAQLCK--HTLDRWDNTSSSPSNRSISLLSLAKTEFISFAKGASFANDLYHSWVAPTLQSNLLVQFWRRST-GILPSDCSPNWEVLNIDLISPGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESC 353
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 159.073 bits (401), Expect = 1.644e-44
Identity = 112/347 (32.28%), Postives = 165/347 (47.55%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIKYPGVYN--------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDD--KSKNVSGSND--GHLKGVINFDEETGYWLIHSVPHFPPVRG---YSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMH-----SPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSA--TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
             + I C +++   +DWY   K P  ++        + ++  E+ G  W      +N  ++ V  T+   Y   +      Y  YND   K K V G++   GH KGV+ FD+E G+WL+HS PHFPP +    +SYP     NGQ+FICV+        + +QL +    ++    P S          L +  H +      S S  +  I L +++K   I F K   FANDLY   +AP L+ +L V+ W     G  PS+C   ++V NI  +     V      DHSKWAV+ S+ TS    C+GDINR E++  RGGG++C     VW A+  A    E C
Sbjct:   16 FSSISCYNDQGKPVDWYYLYKLPHEHHTPLEEGLKYLFMDVESEG--WTDGTTLVNDTQSAVGRTVGPLYEGGD----VGYILYNDQPPKQKQVEGASRSCGHTKGVVVFDKEQGFWLVHSTPHFPPPKSEGQFSYPTSGISNGQNFICVTYPFERFQTIGEQLKINQPHIFDCSIPGSLATAVPAMAQLCK--HTLDRWDNTSSSPSNRSISLLSLAKTEFISFAKGASFANDLYHSWVAPTLQSNLLVQFWRRST-GILPSDCSPNWEVLNIDLISPGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESC 353
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Xenopus
Match: dnase2b (deoxyribonuclease II beta [Source:NCBI gene;Acc:496759])

HSP 1 Score: 186.808 bits (473), Expect = 3.381e-55
Identity = 110/334 (32.93%), Postives = 170/334 (50.90%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVY-------NFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKS-NVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A+I C++E    +DW++  K P +           YL  ++    W++  + +N+ K+ V   L Q Y    +K+ T Y  YND      + +  GH KG++ FD   G+WLIHSVPHFPP    GY YP      GQ+ ICV+ + ++  ++  QLL     VY+   P  +     +   L ++    H P I S  +  LN+      ++F KSK F +D+++  IA +L+ ++ VESW +    +  SNC L Y VYNI  + +          DHSKW V+ SN    TCIGD+NR  +Q  R GG +C  + ++++AF   V  Y+ C
Sbjct:    6 AEISCRNEAGDPIDWFVVYKLPMLKMNGSTGSGLDYLYMDSTNQEWQISKFQINTTKSAVGQVLQQLYQ-DYDKNNTVYMIYNDAPPNVTNSTRKGHTKGILFFDNSQGFWLIHSVPHFPPYPEDGYGYPSTGKRFGQTAICVTYQYNEFKEIATQLLYYNPNVYNCSVPDIYQKEMWM---LHKICLGGHFPWIDSTRLTQLNSARGEVFLNFAKSKYFIDDIFAAWIAQKLRTNMLVESWQSRQ--QLSSNCSLQYHVYNINRIGLPTQSTFQTFYDHSKWCVSQSNEDLWTCIGDLNRHPAQTRRSGGFICTQNKHIYTAFRNMVLYYKNC 333
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Xenopus
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:NCBI gene;Acc:733868])

HSP 1 Score: 175.252 bits (443), Expect = 1.246e-50
Identity = 110/334 (32.93%), Postives = 159/334 (47.60%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIKYPGVYN------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSK-NVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
             A   C  +    +DW+I  K P + N        Y+  +++   W      +NS  + V  T+SQ Y A   KD   Y  YND+ +  + SGS+ GH KG++  D++ G+WL+HS P FPP   + Y +P   H NGQSF+CV+       D+ +QLL      Y    P  F+ +   +         +  P     V+ L ++       F K   F++DLYS  ++  LK  LFV+ W N   G  PSNC L +  YNI  + I      +   DHSKW VT  +     C+GD+NR   +  RGGG++C    NVW +F   VS Y  C
Sbjct:   16 FAATSCYGDHGKQVDWFIVYKLPQLRNKGEEAGMTYVYQDSSSGGWVPGATLMNSTDSAVGQTVSQLYKAFGMKD-VAYILYNDEPANISSSGSDRGHTKGMLLLDKKQGFWLVHSTPRFPPPADQSYDWPLSAHRNGQSFLCVTYPYKQFGDIGQQLLYNTILPYDSSIPEDFSVDFP-ELKTAAEKGAVTQPPWNRQVV-LTSVGGKQFTSFSKHAHFSDDLYSGWVSQVLKSHLFVQFWQNSR-GVLPSNCSLPFHTYNIMEIDISCAYSFSTHNDHSKWCVT--DGAGWACVGDMNRDVKEERRGGGTVCVNDPNVWKSFRSLVSSYNNC 343
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283])

HSP 1 Score: 185.267 bits (469), Expect = 1.450e-54
Identity = 113/334 (33.83%), Postives = 173/334 (51.80%), Query Frame = 3 
Query:  102 KIMCKSEKNLDLDWYIAIKYPGVYN-------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVI-HLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVR-DHSKWAVTL-SNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +I C++E    +DW+I  K P   +         YL  ++   TW    Y +NS ++ +  TL   Y   N+ + T Y  YND    +V+ S   GH KG++ ++   G+WLIHSVP FPPV GY YP      GQ+ IC++   S   ++  QLL++   +YS + P +F  +  L Y + R+  N  S  I    +  L++   +  +HF KS  + +D+++  IA +LK  L  ++W        PSNC L Y VYNIK++ +        R DHSKW V++  +A   TCIGD+NR   Q  RGGG +C  +  ++ AF+K    Y  C+
Sbjct:   25 EISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIY-MPRMCANSSSLKIPVRYLAELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTW-QKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFCK 354
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283])

HSP 1 Score: 185.267 bits (469), Expect = 1.450e-54
Identity = 113/334 (33.83%), Postives = 173/334 (51.80%), Query Frame = 3 
Query:  102 KIMCKSEKNLDLDWYIAIKYPGVYN-------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVI-HLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVR-DHSKWAVTL-SNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +I C++E    +DW+I  K P   +         YL  ++   TW    Y +NS ++ +  TL   Y   N+ + T Y  YND    +V+ S   GH KG++ ++   G+WLIHSVP FPPV GY YP      GQ+ IC++   S   ++  QLL++   +YS + P +F  +  L Y + R+  N  S  I    +  L++   +  +HF KS  + +D+++  IA +LK  L  ++W        PSNC L Y VYNIK++ +        R DHSKW V++  +A   TCIGD+NR   Q  RGGG +C  +  ++ AF+K    Y  C+
Sbjct:   25 EISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIY-MPRMCANSSSLKIPVRYLAELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTW-QKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFCK 354
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019])

HSP 1 Score: 154.451 bits (389), Expect = 7.413e-43
Identity = 100/337 (29.67%), Postives = 156/337 (46.29%), Query Frame = 3 
Query:  105 IMCKSEKNLDLDWYIAIKYPG-------VYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND---GHLKGVINFDEETGYWLIHSVPHFPPVR---GYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILG---VEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + C  +    +DW++  K P             Y   + N + W+     +NS +  V  +L   Y  + N  +  +  YND   K+ S  +    GH KGV+  D+E G+WL+HSVP FPP      Y++P      GQ+ +CVS+  +    + KQL   Y  VY +     F         + +  H +H P   S+VI L + +      F K   F +DLYS  +A  L  +L V+ W N + G  PSNC   Y+V ++      G   +  +   DHSKW V      +  C+GD+NR +++ +RGGG++C    + W AF   V D++ C
Sbjct:   20 LSCYGDSGQPVDWFVVYKLPAHSGSRDTPKGLTYKYMDQNSDGWQDGVGYINSSEGAVGRSLQPLY--RKNSSQLAFLLYNDQPPKSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLLCVSLPFTQFARIGKQLTYTYPLVYDHKLEGFFAQKLPDLETVIKNQHVLHEP-WNSSVI-LTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQN-SPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAPQGPWA--CVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 349
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019])

HSP 1 Score: 147.902 bits (372), Expect = 1.163e-40
Identity = 94/300 (31.33%), Postives = 145/300 (48.33%), Query Frame = 3 
Query:  195 ETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND---GHLKGVINFDEETGYWLIHSVPHFPPVR---GYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILG---VEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + N + W+     +NS +  V  +L   Y  + N  +  +  YND   K+ S  +    GH KGV+  D+E G+WL+HSVP FPP      Y++P      GQ+ +CVS+  +    + KQL   Y  VY +     F         + +  H +H P   S+VI L + +      F K   F +DLYS  +A  L  +L V+ W N + G  PSNC   Y+V ++      G   +  +   DHSKW V      +  C+GD+NR +++ +RGGG++C    + W AF   V D++ C
Sbjct:   36 DQNSDGWQDGVGYINSSEGAVGRSLQPLY--RKNSSQLAFLLYNDQPPKSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLLCVSLPFTQFARIGKQLTYTYPLVYDHKLEGFFAQKLPDLETVIKNQHVLHEP-WNSSVI-LTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQN-SPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAPQGPWA--CVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 328
[Close]
BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Match: sp|P34387|TG198_CAEEL (Cell-death-related nuclease 7 OS=Caenorhabditis elegans OX=6239 GN=crn-7 PE=2 SV=2)

HSP 1 Score: 195.282 bits (495), Expect = 1.851e-57
Identity = 114/343 (33.24%), Postives = 172/343 (50.15%), Query Frame = 3 
Query:   75 AISFQQHLAKIMCKSEKNLDLDWYIAIKYPGV-------YNFFYLSSE----TNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            ++ F     KI CK+ +   +DW++  K P +         F Y  +E    T GN    PN A       V  T+SQ YSA  +K   F+  Y+DD     + S  GH KGV  FD  TG+WLIHSVP+FPP++ +SYP+     GQSF C S++   L ++ +    + A  Y    P  +        N+        S +       + T+  V L+ + K K F  D+++ LI+ Q K +L VESWLNG+G    + C  T + +++  +++ G+     +DHSKWAV+ S      C GD+NR +SQ  RGGG+LC  + N+W  ++  V   E C+
Sbjct:   10 SVIFTTGNGKIQCKNMRGKSVDWFVVYKLPKLSGAGTSGKEFVYFDAESSDWTRGNDINDPNVA-------VGATVSQVYSA--DKSNNFWFMYSDDDPIKSADSYRGHAKGVSLFDSTTGFWLIHSVPNFPPIKSFSYPNTAEKYGQSFFCASMEVQHLTELAEHWKYIQATPYIINIPEKYATRFPTLKNVEAKQSLPRSATQFWISKPIKTVQGVTLMAYAKHKKFDGDIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPCK 343
[Close]
BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Match: sp|Q9QY48|DNS2B_MOUSE (Deoxyribonuclease-2-beta OS=Mus musculus OX=10090 GN=Dnase2b PE=2 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 1.014e-53
Identity = 113/334 (33.83%), Postives = 173/334 (51.80%), Query Frame = 3 
Query:  102 KIMCKSEKNLDLDWYIAIKYPGVYN-------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVI-HLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVR-DHSKWAVTL-SNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +I C++E    +DW+I  K P   +         YL  ++   TW    Y +NS ++ +  TL   Y   N+ + T Y  YND    +V+ S   GH KG++ ++   G+WLIHSVP FPPV GY YP      GQ+ IC++   S   ++  QLL++   +YS + P +F  +  L Y + R+  N  S  I    +  L++   +  +HF KS  + +D+++  IA +LK  L  ++W        PSNC L Y VYNIK++ +        R DHSKW V++  +A   TCIGD+NR   Q  RGGG +C  +  ++ AF+K    Y  C+
Sbjct:   25 EISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIY-MPRMCANSSSLKIPVRYLAELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTW-QKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFCK 354
[Close]
BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Match: sp|Q9QZK9|DNS2B_RAT (Deoxyribonuclease-2-beta OS=Rattus norvegicus OX=10116 GN=Dnase2b PE=1 SV=1)

HSP 1 Score: 182.956 bits (463), Expect = 8.247e-53
Identity = 115/334 (34.43%), Postives = 168/334 (50.30%), Query Frame = 3 
Query:  105 IMCKSEKNLDLDWYIAIKYPGV-------YNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYND--DKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVK-ILGVEINDVRDHSKWAVTLSNATSA-TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            I C +E    +DW+   K P             YL  ++   TW   ++ +NS ++ +  TL Q Y A N K+ T Y  YND    S N SG N GH KG++ ++   G+WLIHS+P FPPV  +GY YP       QS +C+++K S    +  QLL+    +YS + P  F         +         PS +  V  L +   +  +HF KS  + +D+++  IA +LK  L VESW   N    PSNC L Y VYNIK ++  L  +     DHSKW V+  ++ +  TCIGD+NR   Q  R GG +C  +  ++ +F++ VS Y  C
Sbjct:   26 ISCINEDGKAVDWFAFYKLPRRTSRGGTGMGLDYLYLDSTMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAYLIYNDAVPASVNYSG-NYGHAKGLLVWNRVQGFWLIHSIPKFPPVPEKGYEYPSSGRQYAQSGLCITLKYSQYETIDSQLLVFQPNIYSCFIPNIFRWELIHMPQMCAKSSASKIPSRRLTV--LQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKVHLLVESWQRKN-HELPSNCSLPYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDLNRSPHQALRSGGFICSKNRYIYQSFDRLVSHYASC 355
[Close]
BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Match: sp|Q75WF2|DNA2_ACAPL (Plancitoxin-1 OS=Acanthaster planci OX=133434 PE=1 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 1.064e-51
Identity = 110/337 (32.64%), Postives = 162/337 (48.07%), Query Frame = 3 
Query:  105 IMCKSEKNLDLDWYIAIKYPG-----------VYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDD--KSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFP--PVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILG-VEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + C   KN  +DW+I  K P             Y   Y+  + N    K  + +L  D + +A T+   Y   + K    +  YND     + +     GH KGV+ FD  +G+WL+HSVP FP    + Y++PD    NGQ+ +C++ K      + +QL   Y  VY    P      T    +L + VH    P  +   ++L + S    + F K+  +  DLY   +A   K  L+ E+W NG G    S+C+    VYN+K V + G  +    +DHSKWAVT  +    TCIG INR  SQ YRGGG++C  + NV  AF  +V++YE C
Sbjct:   27 VSCMDNKNKPVDWFIVYKLPQDSASSKPVIREGYGQMYM--DVNNQALKFSSTSLKDDDHAIAYTVDDIYK-NHGKGNLAHVMYNDQPPAGEEIQSGLVGHTKGVLAFDGTSGFWLVHSVPKFPLPASKSYNWPDNAKRNGQTLLCITFKYDQFEKIGQQLKYNYPGVYDSDLPSKLVGKTPSIVDLVKNVHVTSPPWNRQ--LNLQSKSGQTFVSFNKASKWGEDLYKNWLATHFKSGLYCETWQNG-GRNLNSSCEAGLNVYNVKKVSLSGGSDFKGTKDHSKWAVTTKSGLKWTCIGGINRQTSQMYRGGGAVCLENANVHKAFYDSVAEYEPC 357
[Close]
BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Match: sp|Q8WZ79|DNS2B_HUMAN (Deoxyribonuclease-2-beta OS=Homo sapiens OX=9606 GN=DNASE2B PE=2 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 1.184e-51
Identity = 111/338 (32.84%), Postives = 169/338 (50.00%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYP-------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNK-DKTFYAFYNDDKSKNVSGSND-GHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVI-HLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVE-INDVRDHSKWAVTLSNATSA-TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            A I C++E+   +DW+   K P       G     YL  ++   +W+     +N  K+++  TL Q Y A  +K + T Y  YND   K V+ S   GH KG++ ++   G+WLIHS+P FPP+   GY YP     NGQS IC++ K +    +  QLL+    VYS   P +F        ++ +L     S  I   ++  L +      +HF KS  F +D+++  +A +LK  L  E+W        PSNC L Y VYNIK +K+      +  +DH+KW ++     +  TCIGD+NR   Q +R GG +C  +  ++ AF   V  YE C+
Sbjct:   28 ATISCRNEEGKAVDWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSCSIPATFHQELI---HMPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKR-QELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK 361
[Close]
BLAST of Deoxyribonuclease II vs. TrEMBL
Match: F1L824 (Cell-death-related nuclease 7 OS=Ascaris suum OX=6253 PE=2 SV=1)

HSP 1 Score: 230.72 bits (587), Expect = 1.398e-68
Identity = 128/338 (37.87%), Postives = 193/338 (57.10%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGV---------YNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSND---GHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNM---HSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A I C+  K   +DW+I  K P V          +F YL  + +  +W   +  +NS ++ +ALTL+Q Y++ ++   TFY  YND+  +  +G  D   GH KGV  F+ ++G+WLIHSVP+FP  R Y+YP   H NGQSF+C+++++  L+ +  Q+L +   +Y+   P  F +      +L ++V       S +I  +V  L + S V    F K K F  DLYS L+APQLK SL  E+WLNG G   PS C   YKV N+ +V++ G +  + +DHSKWAV+        CIGDINR +SQ+ RGGG++C  +  VWS +  ++++ E C
Sbjct:   21 ASISCRDSKGASVDWFIGYKLPVVEGSRSPISGLSFLYL--DGHSTSWS-KSEIINSSQSSIALTLAQLYTSIDDP-ATFYMLYNDEHPE--TGRTDTYRGHAKGVTVFNRDSGFWLIHSVPNFPSTRQYTYPASGHRNGQSFLCITLRSGSLSALATQMLYIQPSIYASQLPTEFASRYP---DLQKVVAKKSLSKSATIFYSVAQLESQSGVKFTSFAKHKKFNKDLYSDLVAPQLKTSLLTETWLNGPGDL-PSICSSPYKVNNVLSVRVDGNQFANSKDHSKWAVSADGTDPVLCIGDINRQKSQWGRGGGTVCIRNTQVWSLYKGSITETEPC 348
[Close]
BLAST of Deoxyribonuclease II vs. TrEMBL
Match: A0A0R3QTY6 (Uncharacterized protein OS=Brugia timori OX=42155 GN=BTMF_LOCUS9222 PE=4 SV=1)

HSP 1 Score: 222.631 bits (566), Expect = 1.236e-65
Identity = 126/336 (37.50%), Postives = 180/336 (53.57%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIK--------YPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKT-FYAFYNDDKSKNVSGS--NDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +A+  CK+     +DW++  K        YPGV  F Y  ++ +   W  P   L S KN +A+TL Q Y  KNNK K  FY FYND    N   S  N  H KGV  F   +G+WL+HSVP FP ++ YSY +     GQSF+CV++KT+ +      +  +Y  VY    PR+F     L  +L  L     S ++ S + +  +   V    F K+  +  DLY  LIA ++  SLF E+W+NG      S C   YKV N+K + + G +    RDHSKWA+  +      CIGDINR ESQ  RGGG++C ++ N+W+ +NK+++D E C+
Sbjct:   19 MAQFSCKNRNGKSVDWFVGYKQPKKASQTYPGV-TFHY--ADNDSKEWG-PAENLKSPKNAIAVTLKQYYDNKNNKKKELFYLFYNDQAPVNEKKSHLNRAHAKGVAVFGNTSGFWLVHSVPKFPSLKRYSYAENGQTYGQSFLCVTLKTTSIKVFANAMRYIYPEVYGITVPRNFLNRFPLLEDLKELKKKRIS-NMSSLLQNFKSNGNVDFFAFSKTGKYNKDLYLDLIAKEMNVSLFAETWMNGAAKDLNSECTTKYKVINVKELNVAGDKFASNRDHSKWAIAENKTKPLVCIGDINRQESQKKRGGGAVCLLNKNIWNLYNKSITDVESCK 349
[Close]
BLAST of Deoxyribonuclease II vs. TrEMBL
Match: A0A4E9EYD4 (Uncharacterized protein OS=Brugia malayi OX=6279 GN=Bma-crn-7.1 PE=4 SV=1)

HSP 1 Score: 222.631 bits (566), Expect = 1.236e-65
Identity = 126/336 (37.50%), Postives = 180/336 (53.57%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIK--------YPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKT-FYAFYNDDKSKNVSGS--NDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +A+  CK+     +DW++  K        YPGV  F Y  ++ +   W  P   L S KN +A+TL Q Y  KNNK K  FY FYND    N   S  N  H KGV  F   +G+WL+HSVP FP ++ YSY +     GQSF+CV++KT+ +      +  +Y  VY    PR+F     L  +L  L     S ++ S + +  +   V    F K+  +  DLY  LIA ++  SLF E+W+NG      S C   YKV N+K + + G +    RDHSKWA+  +      CIGDINR ESQ  RGGG++C ++ N+W+ +NK+++D E C+
Sbjct:   19 MAQFSCKNRNGKSVDWFVGYKQPKKASQTYPGV-TFHY--ADNDSKEWG-PAENLKSPKNAIAVTLKQYYDNKNNKKKELFYLFYNDQAPVNEKKSHLNRAHAKGVAVFGNTSGFWLVHSVPKFPSLKRYSYAENGQTYGQSFLCVTLKTTSIKVFANAMRYIYPEVYGITVPRNFLNRFPLLEDLKELKKKRIS-NMSSLLQNFKSNGNVDFFAFSKTGKYNKDLYLDLIAKEMNVSLFAETWMNGAAKDLNSECTTKYKVINVKELNVAGDKFASNRDHSKWAIAENKTKPLVCIGDINRQESQKKRGGGAVCLLNKNIWNLYNKSITDVESCK 349
[Close]
BLAST of Deoxyribonuclease II vs. TrEMBL
Match: A0A0K0J9G3 (Uncharacterized protein OS=Brugia malayi OX=6279 GN=Bm1_30865 PE=4 SV=2)

HSP 1 Score: 222.631 bits (566), Expect = 1.236e-65
Identity = 126/336 (37.50%), Postives = 180/336 (53.57%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIK--------YPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKT-FYAFYNDDKSKNVSGS--NDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            +A+  CK+     +DW++  K        YPGV  F Y  ++ +   W  P   L S KN +A+TL Q Y  KNNK K  FY FYND    N   S  N  H KGV  F   +G+WL+HSVP FP ++ YSY +     GQSF+CV++KT+ +      +  +Y  VY    PR+F     L  +L  L     S ++ S + +  +   V    F K+  +  DLY  LIA ++  SLF E+W+NG      S C   YKV N+K + + G +    RDHSKWA+  +      CIGDINR ESQ  RGGG++C ++ N+W+ +NK+++D E C+
Sbjct:   19 MAQFSCKNRNGKSVDWFVGYKQPKKASQTYPGV-TFHY--ADNDSKEWG-PAENLKSPKNAIAVTLKQYYDNKNNKKKELFYLFYNDQAPVNEKKSHLNRAHAKGVAVFGNTSGFWLVHSVPKFPSLKRYSYAENGQTYGQSFLCVTLKTTSIKVFANAMRYIYPEVYGITVPRNFLNRFPLLEDLKELKKKRIS-NMSSLLQNFKSNGNVDFFAFSKTGKYNKDLYLDLIAKEMNVSLFAETWMNGAAKDLNSECTTKYKVINVKELNVAGDKFASNRDHSKWAIAENKTKPLVCIGDINRQESQKKRGGGAVCLLNKNIWNLYNKSITDVESCK 349
[Close]
BLAST of Deoxyribonuclease II vs. TrEMBL
Match: A0A0N5AHC8 (Uncharacterized protein OS=Syphacia muris OX=451379 PE=4 SV=1)

HSP 1 Score: 220.32 bits (560), Expect = 1.245e-64
Identity = 118/331 (35.65%), Postives = 179/331 (54.08%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPG------VYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDD-KSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            + I C++   L +DW++A K P             L ++   + W+ P   + S ++ VALTLSQ Y + N+   TFY  YND+    + S ++ GH KG I FD+ +G+ LIHSVPHFPP   Y YP     NGQSF+C++    +LN +  Q+      +Y    P  F     L   +  +        + S+V HL ++S +P + F K K +  DLY+  +AP +K++LFVE+WLNG G    S+C   YKV N+ ++++        +DHSKWA++  +     CIGDINR  SQ  R GG++CF + N+W  F K++   E C+
Sbjct:   22 SSITCRNRFGLPVDWFVAYKLPKPAGEAECSGTELLYADNAADNWQSPE-DIKSMQSSVALTLSQYYKSLND-STTFYMLYNDENPGADRSDNSHGHAKGAIVFDKRSGFLLIHSVPHFPPPNTYEYPISGLRNGQSFLCITFAAEELNTLAVQMHYTQPSIYQSQLPVYFATRYPLLQKVIAMQRFQRKIKVFSSVKHLKSLSGIPFLSFAKYKEYRKDLYADFVAPAIKQTLFVETWLNGPGDLS-SSCNTAYKVMNVLSIRLQNFTFPSSKDHSKWAISNDDNEPYLCIGDINRQVSQTMRSGGTMCFQNKNLWKVFKKSIIKVEPCK 349
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Cavefish
Match: dnase2b (deoxyribonuclease 2 beta [Source:NCBI gene;Acc:103030372])

HSP 1 Score: 171.014 bits (432), Expect = 4.153e-49
Identity = 106/335 (31.64%), Postives = 162/335 (48.36%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYP---------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPV--RGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKIL-GVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A + C +E+   +DW+I  K P         GV  + YL +     TW++  YA+N+    V  TL + Y    + + + Y  YND        SN GH KG + FD   G+W+ HS+PHFPP    G+ YP    + GQ+  C +        + +QL  +  RVY+   P  +  +      L        +P  +  +  L +      + F KS  + +D+Y+  +A  L+  L VESW   N  + PSNC L Y V NIK V +   +  +   DHSKW V++      TC+GD+NR  +Q YRGGG +C  +  V+ AF +AV+ ++ C
Sbjct:   38 ANLSCLNEEGQPVDWFIMYKLPKYKKGEVGSGV-EYMYLDASML--TWRMSPYAVNTSDGAVGRTLGRLYKTYKS-NSSVYMLYNDAPPLLKYQSNYGHSKGTLLFDRSQGFWITHSIPHFPPFLEMGFGYPSTGKLYGQTVHCTTYSYEQFKKISQQLAYINPRVYNCSVPVPYHTDMAAMAQLCGGKRPTVAP--RRKLEKLKSALGETFLSFSKSHQYVDDIYAGWVAQTLRTDLLVESWQRDNH-QLPSNCSLPYHVLNIKRVHLPENITFSSYEDHSKWCVSVEFRAQWTCLGDLNRESTQAYRGGGLICSQNPVVYKAFRQAVAWFKGC 365
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Cavefish
Match: dnase2 (deoxyribonuclease-2-alpha-like [Source:NCBI gene;Acc:103028211])

HSP 1 Score: 156.762 bits (395), Expect = 9.509e-44
Identity = 105/346 (30.35%), Postives = 158/346 (45.66%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYN------FFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYND-----DKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVR---GYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNL------GRLVHNMHSPSIKS--NVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKI-LGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + + C  ++   +DW+   K P  +         YL  E     W   +  +      +  T+   Y     + +  Y  YND     D+ +N   S  GH KGV+ FD++ G+WL+HS PHFPP++    +SYP+    NGQ+FICV+        + +QL +    VY  + P S  ++     NL       R   N   PS  S    + L ++     I F K   F NDLY   +AP L+  L V+ W    G  E S+C  +YKV NI+ +     +      DHSKWA ++S      C+GDINR E++  RGGG++C  +  VW A+       + C
Sbjct:   18 STLSCYDDQGNTVDWFYLYKLPRPHEAPREEGLKYLLQEEKSEGWVDGSVLVEDTSGALGRTVGPLY----EEGELGYILYNDQPPEKDRLENAHRSA-GHTKGVVLFDDKQGFWLVHSTPHFPPLKTEGKFSYPESGTQNGQNFICVTYPLDRFETIGEQLKINQPHVYDCHIPESLASSVPSMVNLCKENQHRRNSSNAPPPSYSSANRSVSLLSLGGKEFISFAKGAAFDNDLYHSWVAPALQADLLVQFWRRSTGILE-SDCDPSYKVLNIQLLSPGQKLTFKSTEDHSKWAASVSG--DWVCVGDINRNEAEEKRGGGTVCHKNAVVWKAYRATALQCDSC 355
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Sea Lamprey
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 152.91 bits (385), Expect = 3.266e-43
Identity = 103/333 (30.93%), Postives = 159/333 (47.75%), Query Frame = 3 
Query:  105 IMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSA-KNNKDKTFYAFYNDDKSKNVS-GSNDGHLKGVINFDEETGYWLIHSVPHFPP-VRG-YSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTAN-TTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLF---ANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGV-EINDVRDHSKWAVTLSNATSA---TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            + C + +   +DW+I  K P   ++ YL   T   +W+     ++S+ + V  T++Q Y           +  YND+   +    S  GH KGV+  D   G+WL+HS PHFPP V G +++P      GQSF+CVS       D+  QL       YS             L     +    + S    + V+ L + +      F K+  F   A+DLY  L+AP LK SL++ESW++G G  + SNC   + V  + ++ +  V   +   DHSKW V+ +  +      C+GDINR   + YRGGG++C     +W+AF KA +  E C
Sbjct:    1 VSCLNGEGKSVDWFIVYKLPKGKDYLYLDKSTQ--SWQNAQVDVDSNSSPVYQTVNQLYDGNATEAGDVAFVLYNDEPPNSPHYDSICGHTKGVVMLDGTGGFWLVHSTPHFPPSVPGPFAWPHTALRYGQSFLCVSYGFDQFGDIALQLRYNEPDHYSCQVGAQLKDKLPDLQALCAKTKLQVES---ATRVVELTSSAGKTFRSFAKTHRFDDGASDLYVHLVAPNLKSSLYLESWVHGVGVFD-SNCSGEFCVCRVSSISLPSVAPFSSEEDHSKWCVSQTGGSPGGAWACVGDINRNRGEEYRGGGTVCTDDPAIWAAFAKATTSVEPC 327
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Medaka
Match: dnase2b (deoxyribonuclease-2-beta [Source:NCBI gene;Acc:101174093])

HSP 1 Score: 176.407 bits (446), Expect = 3.171e-51
Identity = 111/338 (32.84%), Postives = 166/338 (49.11%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYP---------GVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKN-NKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFP--PVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSN--VIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILG-VEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            A I C++E+   +DW+I  K P         GV  + YL        W++  Y +N+ +  +A TL Q Y  K    + + Y  YND           GH KGV+ FD   G+WL HS+PHFP  P RGY YP    +NGQ+ +C++ + +    + +QL  +Y R Y+   P + +A+      L +L      P++ S+  +  L +      I F KS  F +D+Y+  +A  L   L VESW    G   PSNC L     NIK +++   V      DHSKW V+ +     TC+GD+NR  +Q +RGGG +C  +  ++ AF + V  Y  C
Sbjct:   23 ADISCRNEEGNPVDWFIIYKLPKYKVGEVGSGV-EYMYLDESVA--RWQMSKYMINTSQGAIANTLKQLYMGKAYMSNSSVYVLYNDGPPDLKYIQAYGHTKGVLLFDHAKGFWLSHSIPHFPSFPERGYLYPSSGKLNGQTLLCMTYQYAQFLKIAQQLEYLYPRFYNCSVPAALSADLP---QLAKLCAG-SKPALASDKSMQPLFSNRGEKFISFVKSDHFVDDIYTGWVAQVLDTDLLVESW-QTQGRVLPSNCSLPRHAMNIKRIQLPTLVRFQSYYDHSKWCVSQAYEDQVTCLGDLNRERAQLWRGGGLICSDNPVIYKAFRQLVDWYISC 352
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Medaka
Match: dnase2 (deoxyribonuclease 2, lysosomal [Source:NCBI gene;Acc:101162954])

HSP 1 Score: 167.933 bits (424), Expect = 6.388e-48
Identity = 107/346 (30.92%), Postives = 159/346 (45.95%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYNFF-------YLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYND----DKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRG---YSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNL---GRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGV-EINDVRDHSKWAVTLSNATSA-----TCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            ++I C +++   +DW+   K P  +          YL  E  G  W      +N     +  T+ Q YS + + +   Y  YND    D   + SG++ GH KGV+  D+  G+WL+HS PHFPP R    Y YP     NGQ+F+CV+        + +QL +    VY    P S  +       L    RL   + S  + +  + L ++     I F K   F +DLY   +AP L+  L V+ W+    G  PS+C L +KV +I  +         + +DHSKWAV+   A         C+GDINR E++  RGGG++C     VW A+  A    E C
Sbjct:   18 SQISCYNDQGDAVDWFYIYKLPKEHQKTAPRRGEQYLLLEKGGEGWMEGKVTVNDSSGALGRTVGQLYSERKSSE-VAYVLYNDQSPVDGFGDGSGNSGGHTKGVVLLDQNQGFWLVHSTPHFPPERQAGEYYYPSSGVNNGQNFLCVTYPLKSFQTIGEQLQINQPHVYDCDIPESMVSLVPALAALCKKARLSDEVSSRPMSNRSMTLTSMDGTNFISFAKGASFDDDLYHGWVAPALQSDLLVQFWIRST-GILPSDCSLGWKVLDITLINPGQTFAFKNSQDHSKWAVSPKQAWGGKGGGWVCVGDINRNEAEEKRGGGTVCLQDPVVWKAYRSAALQCEAC 361
[Close]
BLAST of Deoxyribonuclease II vs. Ensembl Medaka
Match: ENSORLT00000036979.1 (deoxyribonuclease-2-alpha [Source:NCBI gene;Acc:101173852])

HSP 1 Score: 166.392 bits (420), Expect = 1.506e-47
Identity = 110/341 (32.26%), Postives = 168/341 (49.27%), Query Frame = 3 
Query:   75 AISFQQHLAKIMCKSEKNLDLDWYIAIKYPGVY----NFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTF-YAFYNDDKSKN-VSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSY-PDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQ--LTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
             I F    + + C+++  +++DWYI  K         ++ Y+   TNG  W + N  ++S    +  TL         + + F Y  YND      V+  + GH KGV+  D +TG WL HS P FP  R  ++ P+  + N Q+F+C++   +    +  QL  ++A  +  + P+ F  +  L     R  +    P  K  V +L ++     + F K   F +DLYS LI   L  +L+V+SW   +     SNC   + + VYN+KTVK+L  + ND  DHSKW VT  +  + TC+ D+NR  SQ  RGGG+LC     V  AF   +S YE CQ
Sbjct:   14 GIFFHGCQSDVRCRNDHGVEVDWYILYKLRNTQKDGSSYLYMDENTNG--WTVSNQKIDSRSGCLGWTLKPLLDFYVKQTEGFGYLLYNDQPPNPYVAPKSFGHSKGVVMLDRQTGVWLSHSTPRFPTYRSQNFWPESGNANAQAFMCITFPYAQFEAIGLQLKYIHAYSFDSHVPQVF--HMELQCVAQRSCYPKKEPWFK--VANLKSMGGHSFLSFAKYTRFKDDLYSGLITNTLPSNLYVKSWGKMHDSLA-SNCSSSIPHHVYNVKTVKLLKRDFNDTVDHSKWCVT--SDENWTCVADMNRETSQMGRGGGALCMDSYEVAKAFRSTISAYEPCQ 345
[Close]
BLAST of Deoxyribonuclease II vs. Planmine SMEST
Match: SMESG000081036.1 (SMESG000081036.1)

HSP 1 Score: 684.485 bits (1765), Expect = 0.000e+0
Identity = 329/332 (99.10%), Postives = 330/332 (99.40%), Query Frame = 3 
Query:   75 AISFQQHLAKIMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            AISFQQHLAKIMCKSEKN DLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSA+NNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIH NVWSAFNKAVSDYEKCQ
Sbjct:   12 AISFQQHLAKIMCKSEKNSDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAENNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHANVWSAFNKAVSDYEKCQ 343
[Close]
BLAST of Deoxyribonuclease II vs. Planmine SMEST
Match: SMESG000081036.1 (SMESG000081036.1)

HSP 1 Score: 660.988 bits (1704), Expect = 0.000e+0
Identity = 318/321 (99.07%), Postives = 319/321 (99.38%), Query Frame = 3 
Query:  108 MCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ 1070
            MCKSEKN DLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSA+NNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIH NVWSAFNKAVSDYEKCQ
Sbjct:    1 MCKSEKNSDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAENNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHANVWSAFNKAVSDYEKCQ 321
[Close]
BLAST of Deoxyribonuclease II vs. Planmine SMEST
Match: SMESG000062594.1 (SMESG000062594.1)

HSP 1 Score: 324.324 bits (830), Expect = 5.208e-109
Identity = 160/324 (49.38%), Postives = 214/324 (66.05%), Query Frame = 3 
Query:   96 LAKIMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            L +I C++E N  LDW++AIK+P  YNF YLSS    + WK  NY L S+KNL+A+TL Q+Y   N K   FY +YNDD+  + S +  GHLKG++N D+ TGYWL HSVP+FP    Y +   Q I GQSF+CVSIK + L  +V+QLL+M A VYS ++P SFT +  L   L RL+ N+ S ++ SN++H  T++ + L+HF KS  +  DLYS LIAP L  SLFVE+W NG G +  S C+L YKV N++ + +         DHSKWA++ S ++   CIGDINRMESQF RGGGSLC  + N+W  F K++  YEKC
Sbjct:   21 LCEITCRNENNEYLDWFVAIKHPKSYNFVYLSSANADSHWKESNYDLKSEKNLIAITLQQSYLHCNTK--CFYIYYNDDRPLSNSSTKGGHLKGILNMDDSTGYWLTHSVPNFPMENEYFFNKAQSIYGQSFMCVSIKNTYLKPIVQQLLMMQATVYSSFYPTSFTNDMELISLLPRLIKNIRSKNLVSNILHFKTLNSMNLLHFAKSPKYDQDLYSKLIAPTLNGSLFVETWRNGRGSKLDSACELKYKVNNVEEINLSNKSFKSTSDHSKWAISQSKSSPYICIGDINRMESQFKRGGGSLCTSNVNIWEKFYKSIKTYEKC 342
[Close]
BLAST of Deoxyribonuclease II vs. Planmine SMEST
Match: SMESG000062993.1 (SMESG000062993.1)

HSP 1 Score: 288.115 bits (736), Expect = 9.213e-95
Identity = 144/328 (43.90%), Postives = 210/328 (64.02%), Query Frame = 3 
Query:   87 QQHLAKIMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNV-IHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKC 1067
            Q  + ++ CK+E N D++W+I +K+P  Y F Y+SS++   TW    + L+S  N++  T+ Q YS+  ++ ++FYA+YND+  K  + S+ GHLKGVI+FD   G+WLIHSVP FP    Y+Y   + I GQSFICVS+++ +L ++V QLLLM + VYSY  P +F  N  L   L   ++N +    ++N+ I + T+  +PL+HFGKS  F  DLYS L+AP L+ S+ VESW+ G   +  S C   Y VYN++ V + G +  +  DHSKWAV+ +  +   CIGDINRM SQF RGGG+LC  + N+W  F   V+D+EKC
Sbjct:   15 QLAICELSCKNENNQDIEWFIGLKFPKSYKFVYISSQSE--TWTTSKFDLSSKNNMIGWTIEQTYSS--HQSQSFYAYYNDETPK-FTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGE--KVDSTCGTDYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 335
[Close]
BLAST of Deoxyribonuclease II vs. Planmine SMEST
Match: SMESG000081051.1 (SMESG000081051.1)

HSP 1 Score: 174.866 bits (442), Expect = 2.587e-52
Identity = 97/210 (46.19%), Postives = 130/210 (61.90%), Query Frame = 3 
Query:   99 AKIMCKSEKNLDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNVIHLNTISKVPLIHFGKSKLF 728
            + + CK+E N D+DW+IAIK P V +F  LSS++N   W L +Y L +  N +ALT+ Q Y +K    + FY +YND+ +      N GH KGV+ FD+  GYWL+HSVP FP    Y Y   Q   GQSFICVS+K  +LN +V QLL+M   VYSY+ P  F+ N++L   +  LV+N    S  SNV + NT+    LIHFGKS+LF
Sbjct:   22 SSLSCKNENNEDVDWFIAIKPPHVDSFSSLSSQSNNTDWLLSSYKLTNGNNSIALTIKQTYESK--LKQRFYVYYNDEDTAGNEKYNMGHSKGVVTFDKSEGYWLVHSVPKFPFPNEYKYGSGQLKFGQSFICVSLKFQNLNSLVDQLLIMTTNVYSYFVPEGFSQNSSLMDKINSLVNNSIKKSKDSNVFNFNTVKNFNLIHFGKSRLF 229
The following BLAST results are available for this feature:
BLAST of Deoxyribonuclease II vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
DNASE2B2.466e-5232.84deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:H... [more]
DNASE21.524e-4230.70deoxyribonuclease 2, lysosomal [Source:HGNC Symbol... [more]
DNASE2B1.275e-2035.07deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:H... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
crn-71.455e-5833.24Cell-death-related nuclease 7 [Source:UniProtKB/S... [more]
nuc-11.450e-4630.83Deoxyribonuclease-2 [Source:UniProtKB/Swiss-Prot;... [more]
crn-61.407e-4531.12Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
crn-61.407e-4531.12Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
crn-61.412e-4531.12Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
DNaseII1.482e-4932.29gene:FBgn0000477 transcript:FBtr0083538[more]
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BLAST of Deoxyribonuclease II vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
dnase2b1.143e-4632.37deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
dnase2b4.683e-4632.74deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
dnase21.644e-4432.28deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
dnase21.644e-4432.28deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dnase2b3.381e-5532.93deoxyribonuclease II beta [Source:NCBI gene;Acc:49... [more]
dnase21.246e-5032.93deoxyribonuclease II, lysosomal [Source:NCBI gene;... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Dnase2b1.450e-5433.83deoxyribonuclease II beta [Source:MGI Symbol;Acc:M... [more]
Dnase2b1.450e-5433.83deoxyribonuclease II beta [Source:MGI Symbol;Acc:M... [more]
Dnase2a7.413e-4329.67deoxyribonuclease II alpha [Source:MGI Symbol;Acc:... [more]
Dnase2a1.163e-4031.33deoxyribonuclease II alpha [Source:MGI Symbol;Acc:... [more]
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BLAST of Deoxyribonuclease II vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P34387|TG198_CAEEL1.851e-5733.24Cell-death-related nuclease 7 OS=Caenorhabditis el... [more]
sp|Q9QY48|DNS2B_MOUSE1.014e-5333.83Deoxyribonuclease-2-beta OS=Mus musculus OX=10090 ... [more]
sp|Q9QZK9|DNS2B_RAT8.247e-5334.43Deoxyribonuclease-2-beta OS=Rattus norvegicus OX=1... [more]
sp|Q75WF2|DNA2_ACAPL1.064e-5132.64Plancitoxin-1 OS=Acanthaster planci OX=133434 PE=1... [more]
sp|Q8WZ79|DNS2B_HUMAN1.184e-5132.84Deoxyribonuclease-2-beta OS=Homo sapiens OX=9606 G... [more]
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BLAST of Deoxyribonuclease II vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F1L8241.398e-6837.87Cell-death-related nuclease 7 OS=Ascaris suum OX=6... [more]
A0A0R3QTY61.236e-6537.50Uncharacterized protein OS=Brugia timori OX=42155 ... [more]
A0A4E9EYD41.236e-6537.50Uncharacterized protein OS=Brugia malayi OX=6279 G... [more]
A0A0K0J9G31.236e-6537.50Uncharacterized protein OS=Brugia malayi OX=6279 G... [more]
A0A0N5AHC81.245e-6435.65Uncharacterized protein OS=Syphacia muris OX=45137... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dnase2b4.153e-4931.64deoxyribonuclease 2 beta [Source:NCBI gene;Acc:103... [more]
dnase29.509e-4430.35deoxyribonuclease-2-alpha-like [Source:NCBI gene;A... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
dnase23.266e-4330.93deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
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BLAST of Deoxyribonuclease II vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Deoxyribonuclease II vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Deoxyribonuclease II vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dnase2b3.171e-5132.84deoxyribonuclease-2-beta [Source:NCBI gene;Acc:101... [more]
dnase26.388e-4830.92deoxyribonuclease 2, lysosomal [Source:NCBI gene;A... [more]
ENSORLT00000036979.11.506e-4732.26deoxyribonuclease-2-alpha [Source:NCBI gene;Acc:10... [more]
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BLAST of Deoxyribonuclease II vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081036.10.000e+099.10SMESG000081036.1[more]
SMESG000081036.10.000e+099.07SMESG000081036.1[more]
SMESG000062594.15.208e-10949.38SMESG000062594.1[more]
SMESG000062993.19.213e-9543.90SMESG000062993.1[more]
SMESG000081051.12.587e-5246.19SMESG000081051.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001221 ID=SMED30001221|Name=Deoxyribonuclease II|organism=Schmidtea mediterranea sexual|type=transcript|length=1202bp
TAGAACTATATCGAATTTTCAATTATTGAAATTAAATTAAAATGTTGAAA
CTAATACTTGGAATTTTGGTCATTGCAATTTCATTTCAACAACACTTGGC
TAAAATTATGTGTAAAAGTGAAAAAAATTTGGATCTAGATTGGTACATTG
CCATCAAGTACCCAGGTGTGTACAATTTCTTTTACTTGTCTTCCGAAACA
AACGGGAATACTTGGAAGTTGCCGAATTATGCACTCAACAGCGACAAAAA
TTTAGTAGCGCTGACACTTAGTCAAGCTTACAGCGCTAAGAACAATAAAG
ATAAAACTTTCTATGCCTTTTACAATGACGATAAATCAAAAAACGTTTCC
GGTTCAAATGATGGCCATTTAAAAGGAGTTATTAATTTTGACGAAGAAAC
CGGATATTGGCTCATCCATTCTGTGCCTCACTTCCCACCAGTTCGAGGGT
ATTCGTATCCTGATCCGCAACACATTAATGGGCAGTCATTTATTTGCGTT
TCAATTAAAACAAGCGATCTAAATGATGTTGTCAAACAACTTCTGTTAAT
GTATGCGAGAGTTTACAGTTACTATTTTCCGAGATCCTTTACAGCGAATA
CAACATTGGACTATAATCTGGGTCGTTTGGTTCATAACATGCATTCTCCT
TCGATCAAGTCTAATGTCATACATCTCAATACAATTTCCAAAGTCCCACT
TATTCATTTTGGGAAGTCCAAACTTTTTGCAAATGATTTATATTCCGTAT
TAATTGCACCTCAATTAAAAGAAAGTCTTTTCGTTGAAAGTTGGCTGAAT
GGCAACGGGGGCAGAGAACCGTCAAATTGCCAATTAACATATAAAGTTTA
TAATATAAAAACAGTGAAAATATTGGGTGTAGAAATTAATGATGTAAGAG
ACCATTCTAAGTGGGCAGTTACGTTATCCAACGCCACTAGTGCTACCTGC
ATTGGAGATATCAACCGAATGGAAAGTCAATTTTACCGAGGTGGTGGTTC
ACTTTGTTTCATTCATGGAAATGTCTGGTCGGCATTCAACAAGGCTGTTT
CTGATTACGAAAAATGTCAATAAGATTACTTTTGCACAATTTAGTCTGAC
AATTTTTATAATTTAAATAACAGTTTTCATAAATTACTTTTTCTCACTAT
TCAAACAAAATCAGCTAAATTTTATTTTTTTATTTAATTTTGCAGATGCA
GG
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protein sequence of SMED30001221-orf-1

>SMED30001221-orf-1 ID=SMED30001221-orf-1|Name=SMED30001221-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=344bp
MLKLILGILVIAISFQQHLAKIMCKSEKNLDLDWYIAIKYPGVYNFFYLS
SETNGNTWKLPNYALNSDKNLVALTLSQAYSAKNNKDKTFYAFYNDDKSK
NVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSF
ICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNM
HSPSIKSNVIHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVES
WLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATS
ATCIGDINRMESQFYRGGGSLCFIHGNVWSAFNKAVSDYEKCQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0003116parenchymal cell
Vocabulary: biological process
TermDefinition
GO:0006259DNA metabolic process
Vocabulary: molecular function
TermDefinition
GO:0004531deoxyribonuclease II activity
Vocabulary: INTERPRO
TermDefinition
IPR004947DNase_II
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR004947Deoxyribonuclease IIPFAMPF03265DNase_IIcoord: 24..342
e-value: 1.4E-86
score: 290.7
IPR004947Deoxyribonuclease IIPANTHERPTHR10858DEOXYRIBONUCLEASE IIcoord: 8..342
NoneNo IPR availablePANTHERPTHR10858:SF23DEOXYRIBONUCLEASE IIcoord: 8..342
NoneNo IPR availableCDDcd09121PLDc_DNaseII_2coord: 207..342
e-value: 9.19104E-57
score: 178.967
NoneNo IPR availableCDDcd09120PLDc_DNaseII_1coord: 20..155
e-value: 3.49782E-36
score: 125.869
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..20
score: 0.769