Squamous cell carcinoma antigen recognized by T-cells 3

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD---KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK----------------PQKRKT---------PDYKSSGLKAKKVKFSEELSTETVT-----------ASVSIEQPIERCEEK-------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIG--MIPRTVG----------LKPMATQKKIIHGASSDSQDG-----------NIAEAKKSNADFRKFLM 2496
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+  D   ++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RA+RN   ++ LW  Y+  ME +      I  TF           T ++ +WQAYLD+ +R++D +   + +L  +R  F + +      +E   +   DP C +++ W  IEA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   +                P+KR            D +    K ++V+ S   + ET             A+V +E P ++ E+                    T+FVSNL YS+ E D  LR  FE CG++ +IR    +    RG+ +++F  + +  +AL+++R+ +  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + +I+V +S PP ++ P+K           K P G  ++P+T G          L P A Q+     A+  +++G                K SNADF K  +
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTS-LEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETR-------KAPGGPMLLPQTYGARGKGRTQLSLLPRALQRP--SAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFL 961          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD---KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK-------------SPFVDDGS-NEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK----------------PQKRKT---------PDYKSSGLKAKKVKFSEELSTETVT-----------ASVSIEQPIERCEEK-------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIG--MIPRTVG----------LKPMATQKKIIHGASSDSQDG-----------NIAEAKKSNADFRKFLM 2496
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+  D   ++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E              SPF  + + + Q E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RA+RN   ++ LW  Y+  ME +      I  TF           T ++ +WQAYLD+ +R++D +   + +L  +R  F + +      +E   +   DP C +++ W  IEA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   +                P+KR            D +    K ++V+ S   + ET             A+V +E P ++ E+                    T+FVSNL YS+ E D  LR  FE CG++ +IR    +    RG+ +++F  + +  +AL+++R+ +  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + +I+V +S PP ++ P+K           K P G  ++P+T G          L P A Q+     A+  +++G                K SNADF K  +
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARPVAGFLSPFDREQTFDSQLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTS-LEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETR-------KAPGGPMLLPQTYGARGKGRTQLSLLPRALQRP--SAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFL 979          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD---KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCS----------VDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK----------------PQKRKTP---------DYKSSGLKAKKVKFSEELSTETVT-----------ASVSIEQPIERCEEK-------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIG--MIPRTVG----------LKPMATQKKIIHGASSDSQDG-----------NIAEAKKSNADFRKFLM 2496
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+  D   ++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RA+RN   ++ LW  Y+  ME +             ++E+R  F                    YL  E                + E F++          DP C +++ W  IEA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   +                P+KR            D +    K ++V+ S   + ET             A+V +E P ++ E+                    T+FVSNL YS+ E D  LR  FE CG++ +IR    +    RG+ +++F  + +  +AL+++R+ +  RPMFVS C   +K+     F YS  + E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + +I+V +S PP ++ P+K           K P G  ++P+T G          L P A Q+     A+  +++G                K SNADF K  +
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISDSSKELEELRAAFTRALE---------------YLKQE----------------VEERFNE--------SGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTSL-EKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETR-------KAPGGPMLLPQTYGARGKGRTQLSLLPRALQRP--SAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFL 925          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINS---DKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISY 942
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+     D++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I++  ++ERA+ + CL  ++WI Y
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQL--IFERALVENCLVPDLWIRY 350          

Query: 1981 RPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKK 2313
            RPMFVS C   +K+     F YS  + E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + +I+V +S PP ++ P+K
Sbjct:   12 RPMFVSPCVDKSKNPDFKVFRYSTSL-EKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEK 125          

Query:  277 YYPLSPEMWIDWINDEKSINSDKDF--IRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEE------IRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQ-----KERIYKIYLRQLSLSLQSNDET----------LKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIEN---YIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDY---KSSGLK--AKKVK-----FSEELSTET----------------VTASVSIEQPIERCEE-KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK--SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSS--QSIDFKPP-------IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            + PL+P  W +WI D ++   +     +  +F +A+ D   V +W E   +      DK +       R     A+  +GT    G  IW  +L YE S ++ +  N        ++++ ++ R L       ++            K+  +  +  K + + +  K +LSK        FE+ I   ET             K+    ++  + + +     I   +ER +++L   +  WI+Y  +     +  +  + K Y RA+R+   S  L    +   E      +EI   +       +N       L++ Y    +R++      + D + + E+FD+   +      + +D      +   +  A    NM K R +W+ I+ S     +  W+E +  ER+FGD E+ ++  N A+N  +D    +    ++   EE  L       +K+++Q    + R  K+ +E P  P  +   D+   ++SG +   KKVK     F   L                       S ++++     E+ +TIFVSNL ++  E+++RQ  E    +A IR  + ++     RGFA++  ++    ++AL  +R  +  RPMF+S  +   +  F +S   +E +K+FV+N+    T   L+ +F +FG +  +R VT K G PKGIA+V++  E  A K +   D + + +R +EV LS PPVK+  K  G+ ++   S++   P       + ++PR +  K      ++    + D  +G       SN  FRK  M
Sbjct:   65 WAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMS-YLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSK--------FEELIQQEET-------------KKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAV-KVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRI--HLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPA-PAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEG---VASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFST-TLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKD-KSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARL---DAMDVSEGTSTSQPLSNDQFRKMFM 834          

Query:  277 YYPLSPEMWIDWINDEKSINSDKDF--IRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEE------IRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQ-----KERIYKIYLRQLSLSLQSNDET----------LKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIEN---YIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDY---KSSGLK--AKKVK-----FSEELSTET----------------VTASVSIEQPIERCEE-KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK--SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSS--QSIDFKPP-------IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            + PL+P  W +WI D ++   +     +  +F +A+ D   V +W E   +      DK +       R     A+  +GT    G  IW  +L YE S ++ +  N        ++++ ++ R L       ++            K+  +  +  K + + +  K +LSK        FE+ I   ET             K+    ++  + + +     I   +ER +++L   +  WI+Y  +     +  +  + K Y RA+R+   S  L    +   E      +EI   +       +N       L++ Y    +R++      + D + + E+FD+   +      + +D      +   +  A    NM K R +W+ I+ S     +  W+E +  ER+FGD E+ ++  N A+N  +D    +    ++   EE  L       +K+++Q    + R  K+ +E P  P  +   D+   ++SG +   KKVK     F   L                       S ++++     E+ +TIFVSNL ++  E+++RQ  E    +A IR  + ++     RGFA++  ++    ++AL  +R  +  RPMF+S  +   +  F +S   +E +K+FV+N+    T   L+ +F +FG +  +R VT K G PKGIA+V++  E  A K +   D + + +R +EV LS PPVK+  K  G+ ++   S++   P       + ++PR +  K      ++    + D  +G       SN  FRK  M
Sbjct:   65 WAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMS-YLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSK--------FEELIQQEET-------------KKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAV-KVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRI--HLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPA-PAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEG---VASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFST-TLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKD-KSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARL---DAMDVSEGTSTSQPLSNDQFRKMFM 834          

Query:  277 YYPLSPEMWIDWINDEKSINSDKDF--IRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEE------IRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQ-----KERIYKIYLRQLSLSLQSNDET----------LKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIEN---YIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDY---KSSGLK--AKKVK-----FSEELSTET----------------VTASVSIEQPIERCEE-KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK--SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSS--QSIDFKPP-------IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            + PL+P  W +WI D ++   +     +  +F +A+ D   V +W E   +      DK +       R     A+  +GT    G  IW  +L YE S ++ +  N        ++++ ++ R L       ++            K+  +  +  K + + +  K +LSK        FE+ I   ET             K+    ++  + + +     I   +ER +++L   +  WI+Y  +     +  +  + K Y RA+R+   S  L    +   E      +EI   +       +N       L++ Y    +R++      + D + + E+FD+   +      + +D      +   +  A    NM K R +W+ I+ S     +  W+E +  ER+FGD E+ ++  N A+N  +D    +    ++   EE  L       +K+++Q    + R  K+ +E P  P  +   D+   ++SG +   KKVK     F   L                       S ++++     E+ +TIFVSNL ++  E+++RQ  E    +A IR  + ++     RGFA++  ++    ++AL  +R  +  RPMF+S  +   +  F +S   +E +K+FV+N+    T   L+ +F +FG +  +R VT K G PKGIA+V++  E  A K +   D + + +R +EV LS PPVK+  K  G+ ++   S++   P       + ++PR +  K      ++    + D  +G       SN  FRK  M
Sbjct:   65 WAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMS-YLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSK--------FEELIQQEET-------------KKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAV-KVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRI--HLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPA-PAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEG---VASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFST-TLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKD-KSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARL---DAMDVSEGTSTSQPLSNDQFRKMFM 834          

Query:  277 YYPLSPEMWIDWINDEKSINSDKDF--IRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEE------IRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQ-----KERIYKIYLRQLSLSLQSNDET----------LKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIEN---YIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDY---KSSGLK--AKKVK-----FSEELSTET----------------VTASVSIEQPIERCEE-KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK--SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSS--QSIDFKPP-------IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            + PL+P  W +WI D ++   +     +  +F +A+ D   V +W E   +      DK +       R     A+  +GT    G  IW  +L YE S ++ +  N        ++++ ++ R L       ++            K+  +  +  K + + +  K +LSK        FE+ I   ET             K+    ++  + + +     I   +ER +++L   +  WI+Y  +     +  +  + K Y RA+R+   S  L    +   E      +EI   +       +N       L++ Y    +R++      + D + + E+FD+   +      + +D      +   +  A    NM K R +W+ I+ S     +  W+E +  ER+FGD E+ ++  N A+N  +D    +    ++   EE  L       +K+++Q    + R  K+ +E P  P  +   D+   ++SG +   KKVK     F   L                       S ++++     E+ +TIFVSNL ++  E+++RQ  E    +A IR  + ++     RGFA++  ++    ++AL  +R  +  RPMF+S  +   +  F +S   +E +K+FV+N+    T   L+ +F +FG +  +R VT K G PKGIA+V++  E  A K +   D + + +R +EV LS PPVK+  K  G+ ++   S++   P       + ++PR +  K      ++    + D  +G       SN  FRK  M
Sbjct:   65 WAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMS-YLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSK--------FEELIQQEET-------------KKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAV-KVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRI--HLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPA-PAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEG---VASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFST-TLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKD-KSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARL---DAMDVSEGTSTSQPLSNDQFRKMFM 834          

Query: 1612 RMKEEAENPTKPQKRKTPDYKSSGLKA------KKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDL----RQKFEKCGKIAE-----IRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNS--SNKHSFSY-------SVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLS 2283
            R + E + P +P+K +  D   +G +       K ++ + ++   +V ++V +  P   C+ + ++V N+ +  NE  +     Q+   CG +A+     I + + + DK+  FAFI+F S       +  +    + + + V R      ++++F         ++ V  ANK+F+  LP  +T+  ++ +   FG LK   L     G  KG A+ EY +     +A+ G +GM++GD+ + V L+
Sbjct:   97 RREPEPQKPREPKKYRFWDVPPTGFETTTPMEYKNMQAAGQVPRGSVQSAVPVVGPSVTCQSRRLYVGNIPFGCNEEAMLDFFNQQMHLCG-LAQAPGNPILLCQINLDKN--FAFIEFRSIDETTAGMAFDGINFMGQQLKVRRPRDYQPSQNTFDMNSRMPVSTIVVDSANKIFIGGLPNYLTEDQVKELLCSFGPLKAFSLNVDSQGNSKGYAFAEYLDPTLTDQAIAGLNGMQLGDKQLVVQLA 341          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIR-IQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEAN------KLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            P ER + +T+F   L   V   DL + F   GK+ ++R I  +   + +G A+I+FD   +V  AL L  + LL  P+ V    +  K+    +    +        +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ Y N +DA KAL   +G E+  R+++V 
Sbjct:  231 PEER-DARTVFCIQLSQRVRARDLEEFFSSVGKVRDVRLITCNKTKRFKGIAYIEFDDPESVALALGLSGQRLLGVPIMVQHTQAE-KNRLQNAAPAFQPKSHTGPMRLYVGSLHFNITEDMLRGIFEPFGKIDAIQLIMDTETGRSKGYGFITYHNADDAKKALEQLNGFELAGRLMKVG 409          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIR-IQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEAN------KLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            P ER + +T+F   L   V   DL + F   GK+ ++R I  +   + +G A+I+FD   +V  AL L  + LL  P+ V    +  K+    +    +        +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ Y N +DA KAL   +G E+  R+++V 
Sbjct:  231 PEER-DARTVFCIQLSQRVRARDLEEFFSSVGKVRDVRLITCNKTKRFKGIAYIEFDDPESVALALGLSGQRLLGVPIMVQHTQAE-KNRLQNAAPAFQPKSHTGPMRLYVGSLHFNITEDMLRGIFEPFGKIDAIQLIMDTETGRSKGYGFITYHNADDAKKALEQLNGFELAGRLMKVG 409          

Query: 2002 CNSSNKHS-FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQK 2406
             N+  K S F YS  + E NK+FV+NL    +K  L  +F  FG +K++RLV   +   KGIAYVE+    +A +A+ G DG       I V +S PP + +        S +   + P  +IP T+  + +A +K
Sbjct:  706 ANAEAKESNFKYSPNM-EINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGT---SAVKPSVAPKRRVPTSLIPTTLVRQEVAAKK 837          

Query: 2002 CNSSNKHS-FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQK 2406
             N+  K S F YS  + E NK+FV+NL    +K  L  +F  FG +K++RLV   +   KGIAYVE+    +A +A+ G DG       I V +S PP + +        S +   + P  +IP T+  + +A +K
Sbjct:  706 ANAEAKESNFKYSPNM-EINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGT---SAVKPSVAPKRRVPTSLIPTTLVRQEVAAKK 837          

Query: 2002 CNSSNKHS-FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQK 2406
             N+  K S F YS  + E NK+FV+NL    +K  L  +F  FG +K++RLV   +   KGIAYVE+    +A +A+ G DG       I V +S PP + +        S +   + P  +IP T+  + +A +K
Sbjct:  706 ANAEAKESNFKYSPNM-EINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGT---SAVKPSVAPKRRVPTSLIPTTLVRQEVAAKK 837          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSIN---SDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYE-------KSPFVDDGSNEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ----------CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            AEI +++   E +  N  DY+ H  LI  L+   K+   R++R+ M   +PL+ E+W+DW+ DE  I    SD++ +  +F RAI+DY   ++W EY Q+ +G +  +   E +R  FE A+  VG H+TKG  IW  Y  +E       + P     S EQ+E       RI+ ++ RQL++ L   + T  E+   +  +      +  ++  + Q++    P+E+ +            S+ P+  E       +  E + ++++I+  +ERA+ + CL  ++WI Y  YL +   + ++ +L A++RAVRN   ++ LW  Y+  +E +      ++  F           T ++ +WQ+YLD+ +R++D     +++L  +R  F + +    Y+  D +          C+L++ W  IEA +  NM K+RELW  IM       +++WLE    ER +GD  H ++  + AV C +DYPE++C+ +L     E  L+ +    +K +T+  ++ E+R +
Sbjct:   58 AEIQRLE---EQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRITEDESDREKVYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIWEAYREFEIVILSTVQPPPGTVPSQEQQELLSAQLERIHTLFRRQLAVPLMDMEGTYAEY--SDWADDGVPETVTHQYRRALQQMEKGKPYEEALL----------VSEPPKLAEYQSYIDFEIKEGDPARVQII--FERALAENCLVPDLWIKYTTYLDRQL-KIKDLVLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYLRRRVDFSKGKSMELDELRAAFSRSL---EYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKARELWDSIMTKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAVQCTSDYPEHVCDVLLNFERVEGSLEDWDAAVQKTETKLNRVCEQRAR 562          

Query: 1765 ERCEEKTIFVSNLKYSVN--ENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPP-------------IGMIPRTVGLKPMATQK------KIIHGASSDSQDGNIAEAKK-SNADFRKFLM 2496
            +R +E  +FVSNL +++   E  LR  F+ CG I ++R    +    RG+ ++QF+ +  V EALK++R+ +  RPM+VS C   NK+     F Y   + E +K+F+  LP + TK  LE++ K+ G ++ IR+VT +SG  KG+AYVE+ +E  AS+A++  DG  + +  + V +S PP +    KD  + S+ +    P             I ++PR++  +     K         H   +D +     + K  SN DF + L+
Sbjct:  683 QRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTFRGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSM-EKHKIFISGLPYSATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAISNPPGRRM--KDEAAPSRFLGAAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAKAENGTISAPHATVTDGETSLDTQTKSLSNEDFARMLL 949          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSIN---SDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYE-------KSPFVDDGSNEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ----------CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            AEI +++   E +  N  DY+ H  LI  L+   K+   R++R+ M   +PL+ E+W+DW+ DE  I    SD++ +  +F RAI+DY   ++W EY Q+ +G +  +   E +R  FE A+  VG H+TKG  IW  Y  +E       + P     S EQ+E       RI+ ++ RQL++ L   + T  E+   +  +      +  ++  + Q++    P+E+ +            S+ P+  E       +  E + ++++I+  +ERA+ + CL  ++WI Y  YL +   + ++ +L A++RAVRN   ++ LW  Y+  +E +      ++  F           T ++ +WQ+YLD+ +R++D   + + +L  +R  F + +    Y+  D +          C+L++ W  IEA +  NM K+RELW  IM       +++WLE    ER +GD  H ++  + AV C +DYPE++C+ +L     E  L+ +    +K +T+  ++ E+R +
Sbjct:   58 AEIQRLE---EQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRITEDESDREKVYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIWEAYREFEIVILSTVQPPPGTVPSQEQQELLSAQLERIHTLFRRQLAVPLMDMEGTYAEY--SDWADDGVPETVTHQYRRALQQMEKGKPYEEALL----------VSEPPKLAEYQSYIDFEIKEGDPARVQII--FERALAENCLVPDLWIKYTTYLDRQL-KIKDLVLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYLRRRVDFSKEWSRELDELRAAFSRSL---EYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKARELWDSIMTKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAVQCTSDYPEHVCDVLLNFERVEGSLEDWDAAVQKTETKLNRVCEQRAR 562          

Query: 1765 ERCEEKTIFVSNLKYSVN--ENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPP-------------IGMIPRTVGLKPMATQK------KIIHGASSDSQDGNIAEAKK-SNADFRKFLM 2496
            +R +E  +FVSNL +++   E  LR  F+ CG I ++R    +    RG+ ++QF+ +  V EALK++R+ +  RPM+VS C   NK+     F Y   + E +K+F+  LP + TK  LE++ K+ G ++ IR+VT +SG  KG+AYVE+ +E  AS+A++  DG  + +  + V +S PP +    KD  + S+ +    P             I ++PR++  +     K         H   +D +     + K  SN DF + L+
Sbjct:  683 QRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTFRGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSM-EKHKIFISGLPYSATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAISNPPGRRM--KDEAAPSRFLGAAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAKAENGTISAPHATVTDGETSLDTQTKSLSNEDFARMLL 949          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXX-RPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ N+  S++   L   F   G I   ++  D  + S+G+ F+ F++Q     A++    +LL  R +FV    S  +         VE   +++KN  +++    L+NIF +FG    + ++T + G  +G  +V + N  DA +A+   +G E+  RV+ V  ++
Sbjct:  101 IFIKNMDESIDNKALYDTFSAFGNILSCKVVCD-ENGSKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGHFKSRKEREAEMGAKAVEFTNVYIKNFGEDIDSEKLKNIFTEFGKTLSVCVMTDERGRSRGFGFVNFVNHGDARRAVTEMNGKELNGRVLYVGRAQ 267          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDS-HDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDF 2346
            +++V +L   V E  L QKF   G+I  IR+ +D    +S G+A+I F    D++  ++       +    R M+  R     K              +F+KN+ +++   AL + F  FG +   ++V  ++G  KG  +V +  +  A++A+   +GM + DR + V       K   +++ E  +++++F
Sbjct:   12 SLYVGDLHADVTEAMLYQKFSPAGQIMSIRVCRDVITRRSLGYAYINFQQPADAECALDTMNYEVIKGRPIRIMWSQRDPGLRKSG---------VGNIFIKNMDESIDNKALYDTFSAFGNILSCKVVCDENG-SKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGH----FKSRKEREAEMGAKAVEF 190          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXX-RPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ N+  S++   L   F   G I   ++  D  + S+G+ F+ F++Q     A++    +LL  R +FV    S  +         VE   +++KN  +++    L+NIF +FG    + ++T + G  +G  +V + N  DA +A+   +G E+  RV+ V  ++
Sbjct:  101 IFIKNMDESIDNKALYDTFSAFGNILSCKVVCD-ENGSKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGHFKSRKEREAEMGAKAVEFTNVYIKNFGEDIDSEKLKNIFTEFGKTLSVCVMTDERGRSRGFGFVNFVNHGDARRAVTEMNGKELNGRVLYVGRAQ 267          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDS-HDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDF 2346
            +++V +L   V E  L QKF   G+I  IR+ +D    +S G+A+I F    D++  ++       +    R M+  R     K              +F+KN+ +++   AL + F  FG +   ++V  ++G  KG  +V +  +  A++A+   +GM + DR + V       K   +++ E  +++++F
Sbjct:   12 SLYVGDLHADVTEAMLYQKFSPAGQIMSIRVCRDVITRRSLGYAYINFQQPADAECALDTMNYEVIKGRPIRIMWSQRDPGLRKSG---------VGNIFIKNMDESIDNKALYDTFSAFGNILSCKVVCDENG-SKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGH----FKSRKEREAEMGAKAVEF 190          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXX-RPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ N+  S++   L   F   G I   ++  D  + S+G+ F+ F++Q     A++    +LL  R +FV    S  +         VE   +++KN  +++    L+NIF +FG    + ++T + G  +G  +V + N  DA +A+   +G E+  RV+ V  ++
Sbjct:  101 IFIKNMDESIDNKALYDTFSAFGNILSCKVVCD-ENGSKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGHFKSRKEREAEMGAKAVEFTNVYIKNFGEDIDSEKLKNIFTEFGKTLSVCVMTDERGRSRGFGFVNFVNHGDARRAVTEMNGKELNGRVLYVGRAQ 267          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDS-HDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDF 2346
            +++V +L   V E  L QKF   G+I  IR+ +D    +S G+A+I F    D++  ++       +    R M+  R     K              +F+KN+ +++   AL + F  FG +   ++V  ++G  KG  +V +  +  A++A+   +GM + DR + V       K   +++ E  +++++F
Sbjct:   12 SLYVGDLHADVTEAMLYQKFSPAGQIMSIRVCRDVITRRSLGYAYINFQQPADAECALDTMNYEVIKGRPIRIMWSQRDPGLRKSG---------VGNIFIKNMDESIDNKALYDTFSAFGNILSCKVVCDENG-SKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVG----HFKSRKEREAEMGAKAVEF 190          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDF---IRAIFLRAIEDYKSVDVWFEYCQF---MLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FESNCSKIEILNL-YERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDY----------DPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            N  DY+ H  LI  L+   ++   R +R+ M   +PL+ E+W+DW+ DE  +  +  +   +  +F RA++DY   ++W EY Q+    +G      ++R  FE A+  VG H+TKG  +W  Y  +E    +    + Q ERI+K++ RQL + L   + T  E+       +  +  +   ++ + Q++    P+E+ +   ET   A               EY  Y  FE N      + L +ERA+ + CL  ++W  Y +YL +   + ++ +L A+ RAVRN   +++LW  Y+   E +      I   F           T ++ +WQ YLD+ +R++D     + +L  +R +F + +   +Y+            DP CS+++ W  IEA++  NM K+RELW  IM + GNS  +++WLE    ER  GD +H ++  + AV C TDYPE++CE +L +   E  L+ +     K + +  ++ E+R K
Sbjct:   40 NAFDYNCHVDLIKLLRQEGELERLRRARQKMSELFPLTEEIWLDWLKDEMKVADEGSYREKVYELFERAVKDYICPEIWLEYAQYSIGGMGEEGGIAKVRSIFERALTAVGLHMTKGSTLWDAYREFENQQML----HAQLERIHKLFRRQLGVPLFDMNSTYAEY--EEWSEEPMQEALIQSYKKALQQMEKCKPYEEALLAAETPKLA---------------EYQAYIDFEMNAGDPARIQLIFERALVENCLVPDLWARYTQYLDRQL-KVKDLVLSAHDRAVRNCPWTVDLWKRYILATERHCVDHKIISENFEKALNAGFIQATDYVEIWQYYLDYLRRRVDFTKDSSKELEELRSVFVRAL---DYLKQEVEERFGESGDPSCSIMQNWARIEARHCNNMQKARELWDSIM-TRGNSRFANMWLEYYNLERAHGDIQHCRKALHRAVQCTTDYPEHVCEVLLSLERIEGTLEDWDTAVLKTENRLSRVKEQRAK 514          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDF---IRAIFLRAIEDYKSVDVWFEYCQF---MLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FESNCSKIEILNL-YERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ-CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            N  DY+ H  LI  L+   ++   R +R+ M   +PL+ E+W+DW+ DE  +  +  +   +  +F RA++DY   ++W EY Q+    +G      ++R  FE A+  VG H+TKG  +W  Y  +E    +    + Q ERI+K++ RQL + L   + T  E+       +  +  +   ++ + Q++    P+E+ +   ET   A               EY  Y  FE N      + L +ERA+ + CL  ++W  Y +YL +   + ++ +L A+ RAVRN   +++LW  Y+   E +      I   F           T ++ +WQ YLD+ +R++D     + +L  +R +F + +      DY  Q     K+  F+ A++  NM K+RELW  IM + GNS  +++WLE    ER  GD +H ++  + AV C TDYPE++CE +L +   E  L+ +     K + +  ++ E+R K
Sbjct:   17 NAFDYNCHVDLIKLLRQEGELERLRRARQKMSELFPLTEEIWLDWLKDEMKVADEGSYREKVYELFERAVKDYICPEIWLEYAQYSIGGMGEEGGIAKVRSIFERALTAVGLHMTKGSTLWDAYREFENQQML----HAQLERIHKLFRRQLGVPLFDMNSTYAEY--EEWSEEPMQEALIQSYKKALQQMEKCKPYEEALLAAETPKLA---------------EYQAYIDFEMNAGDPARIQLIFERALVENCLVPDLWARYTQYLDRQL-KVKDLVLSAHDRAVRNCPWTVDLWKRYILATERHCVDHKIISENFEKALNAGFIQATDYVEIWQYYLDYLRRRVDFTKDSSKELEELRSVFVRAL------DYLKQEVEERKFLCFLLARHCNNMQKARELWDSIM-TRGNSRFANMWLEYYNLERAHGDIQHCRKALHRAVQCTTDYPEHVCEVLLSLERIEGTLEDWDTAVLKTENRLSRVKEQRAK 479          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDF---IRAIFLRAIEDYKSVDVWFEYCQF---MLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK--------------SPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FESNCSKIEILNL-YERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ-CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            N  DY+ H  LI  L+   ++   R +R+ M   +PL+ E+W+DW+ DE  +  +  +   +  +F RA++DY   ++W EY Q+    +G      ++R  FE A+  VG H+TKG  +W  Y  +E               SP      + Q ERI+K++ RQL + L   + T  E+       +  +  +   ++ + Q++    P+E+ +   ET   A               EY  Y  FE N      + L +ERA+ + CL  ++W  Y +YL +   + ++ +L A+ RAVRN   +++LW  Y+   E +      I   F           T ++ +WQ YLD+ +R++D     + +L  +R +F + +      DY  Q     K+  F+ A++  NM K+RELW  IM + GNS  +++WLE    ER  GD +H ++  + AV C TDYPE++CE +L +   E  L+ +     K + +  ++ E+R K
Sbjct:   20 NAFDYNCHVDLIKLLRQEGELERLRRARQKMSELFPLTEEIWLDWLKDEMKVADEGSYREKVYELFERAVKDYICPEIWLEYAQYSIGGMGEEGGIAKVRSIFERALTAVGLHMTKGSTLWDAYREFENAILGTIQPVPGSIPSPEQQQMLHAQLERIHKLFRRQLGVPLFDMNSTYAEY--EEWSEEPMQEALIQSYKKALQQMEKCKPYEEALLAAETPKLA---------------EYQAYIDFEMNAGDPARIQLIFERALVENCLVPDLWARYTQYLDRQL-KVKDLVLSAHDRAVRNCPWTVDLWKRYILATERHCVDHKIISENFEKALNAGFIQATDYVEIWQYYLDYLRRRVDFTKDSSKELEELRSVFVRAL------DYLKQEVEERKFLCFLLARHCNNMQKARELWDSIM-TRGNSRFANMWLEYYNLERAHGDIQHCRKALHRAVQCTTDYPEHVCEVLLSLERIEGTLEDWDTAVLKTENRLSRVKEQRAK 500          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDF---IRAIFLRAIEDYKSVDVWFEYCQF---MLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYE--------------KSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FESNCSKIEILNL-YERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIE---AKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            N  DY+ H  LI  L+   ++   R +R+ M   +PL+ E+W+DW+ DE  +  +  +   +  +F RA++DY   ++W EY Q+    +G      ++R  FE A+  VG H+TKG  +W  Y  +E               SP      + Q ERI+K++ RQL + L   + T  E+       +  +  +   ++ + Q++    P+E+ +   ET   A               EY  Y  FE N      + L +ERA+ + CL  ++W  Y +YL +   + ++ +L A+ RAVRN   +++LW  Y+   E +      I   F           T ++ +WQ YLD+ +R++D     + +L  +R +F + +      DY  Q  L +  T I+   A++  NM K+RELW  IM + GNS  +++WLE    ER  GD +H ++  + AV C TDYPE++CE +L +   E  L+ +     K + +  ++ E+R K
Sbjct:   16 NAFDYNCHVDLIKLLRQEGELERLRRARQKMSELFPLTEEIWLDWLKDEMKVADEGSYREKVYELFERAVKDYICPEIWLEYAQYSIGGMGEEGGIAKVRSIFERALTAVGLHMTKGSTLWDAYREFENAILGTIQPVPGSIPSPEQQQMLHAQLERIHKLFRRQLGVPLFDMNSTYAEY--EEWSEEPMQEALIQSYKKALQQMEKCKPYEEALLAAETPKLA---------------EYQAYIDFEMNAGDPARIQLIFERALVENCLVPDLWARYTQYLDRQL-KVKDLVLSAHDRAVRNCPWTVDLWKRYILATERHCVDHKIISENFEKALNAGFIQATDYVEIWQYYLDYLRRRVDFTKDSSKELEELRSVFVRAL------DYLKQ-ELFQTRTCIKSNKARHCNNMQKARELWDSIM-TRGNSRFANMWLEYYNLERAHGDIQHCRKALHRAVQCTTDYPEHVCEVLLSLERIEGTLEDWDTAVLKTENRLSRVKEQRAK 497          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDF---IRAIFLRAIEDYKSVDVWFEYCQF---MLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK--------------SPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FESNCSKIEILNL-YERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIE---AKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            N  DY+ H  LI  L+   ++   R +R+ M   +PL+ E+W+DW+ DE  +  +  +   +  +F RA++DY   ++W EY Q+    +G      ++R  FE A+  VG H+TKG  +W  Y  +E               SP      + Q ERI+K++ RQL + L   + T  E+       +  +  +   ++ + Q++    P+E+ +   ET   A               EY  Y  FE N      + L +ERA+ + CL  ++W  Y +YL +   + ++ +L A+ RAVRN   +++LW  Y+   E +      I   F           T ++ +WQ YLD+ +R++D     + +L  +R +F + +      DY  Q  L +  T I+   A++  NM K+RELW  IM + GNS  +++WLE    ER  GD +H ++  + AV C TDYPE++CE +L +   E  L+ +     K + +  ++ E+R K
Sbjct:   40 NAFDYNCHVDLIKLLRQEGELERLRRARQKMSELFPLTEEIWLDWLKDEMKVADEGSYREKVYELFERAVKDYICPEIWLEYAQYSIGGMGEEGGIAKVRSIFERALTAVGLHMTKGSTLWDAYREFENAILGTIQPVPGSIPSPEQQQMLHAQLERIHKLFRRQLGVPLFDMNSTYAEY--EEWSEEPMQEALIQSYKKALQQMEKCKPYEEALLAAETPKLA---------------EYQAYIDFEMNAGDPARIQLIFERALVENCLVPDLWARYTQYLDRQL-KVKDLVLSAHDRAVRNCPWTVDLWKRYILATERHCVDHKIISENFEKALNAGFIQATDYVEIWQYYLDYLRRRVDFTKDSSKELEELRSVFVRAL------DYLKQ-ELFQTRTCIKSNKARHCNNMQKARELWDSIM-TRGNSRFANMWLEYYNLERAHGDIQHCRKALHRAVQCTTDYPEHVCEVLLSLERIEGTLEDWDTAVLKTENRLSRVKEQRAK 521          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSI---NSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-IENYID------YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK-------------------------------------PQKRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEK--------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPR-----------TVGLKPMATQKKIIHGASSDSQDGN----------IAEAKK-SNADFRKFLM 2496
            ++I+   E +  N  DY+ H +LI  L+   ++   R +R+ M   +PL+ E+W++W++DE S+     D++ +  +F RA++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  IW  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+       +     +   ++ +  +L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RAVRN   ++ LW  Y+  ME +      I  TF           T ++ +WQ YLD+ +R++D +   + +L  +R +F + +  ++  ++       DP C +++ W  +EA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   K                                     P KR+  +   +  +A  +K   ELS + +T  V    P  + +EK                    T+FVSNL YS+ E +  LR  FE CG++ +IR    +    RG+ +++F  + + ++AL+L+R+++  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE+I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + VI+V +S PP ++ P+K        +   P   M+PR            + L P A Q++   GA+  +++G             EA K SNADF K L+
Sbjct:   97 LEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYEMEATFAEY--EEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVG---PPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYST-TLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKP------EVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQRQ---GAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLL 960          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSI---NSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYL 954
            ++I+   E +  N  DY+ H +LI  L+   ++   R +R+ M   +PL+ E+W++W++DE S+     D++ +  +F RA++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  IW  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+       +     +   ++ +  +L  Y P+E+ +   E    A               EY  Y +      + ++I++  ++ERA+ + CL  ++WI Y +YL
Sbjct:   97 LEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYEMEATFAEY--EEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQL--IFERALVENCLVPDLWIRYSQYL 355          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXX-RPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ NL+ S++   L   F   G I   ++  + H  SRGF F+ F++    ++A+     +LL  R +FV    S  K         +    ++VKNL  NV +  L+++F QFG ++ ++++   +G  +G  +V +    +A KA+   +G E+  +++ V  ++
Sbjct:  101 IFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHG-SRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQ 267          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYS----VGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            P ER + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+++F   S+V  A+ L  + +L  P+ V    +    + + +     G     +L+V +L  N+T+  L  IF+ FG ++ I+L+   ++G  KG  ++ +S+   A KAL   +G E+  R ++V 
Sbjct:  147 PEER-DARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVG 324          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYS----VGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            P ER + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+++F   S+V  A+ L  + +L  P+ V    +    + + +     G     +L+V +L  N+T+  L  IF+ FG ++ I+L+   ++G  KG  ++ +S+   A KAL   +G E+  R ++V 
Sbjct:  147 PEER-DARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVG 324          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSI---NSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-IENYID------YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK-------------------------------------PQKRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEK--------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPR-----------TVGLKPMATQKKIIHGASSDSQDGN----------IAEAKK-SNADFRKFLM 2496
            ++I+   E +  N  DY+ H +LI  L+   ++   R +R+ M   +PL+ E+W++W++DE S+     D++ +  +F RA++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  IW  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+       +     +   ++ +  +L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RAVRN   ++ LW  Y+  ME +      I  TF           T ++ +WQ YLD+ +R++D +   + +L  +R +F + +  ++  ++       DP C +++ W  +EA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   K                                     P KR+  +   +  +A  +K   ELS + +T  V    P  + +EK                    T+FVSNL YS+ E +  LR  FE CG++ +IR    +    RG+ +++F  + + ++AL+L+R+++  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE+I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + VI+V +S PP ++ P+K        +   P   M+PR            + L P A Q++   GA+  +++G             EA K SNADF K L+
Sbjct:   97 LEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYEMEATFAEY--EEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVG---PPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYST-TLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKP------EVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQRQ---GAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLL 960          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD---KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK----------------PQKRKT---------PDYKSSGLKAKKVKFSEELSTETVT-----------ASVSIEQPIERCEEK-------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIG--MIPRTVG----------LKPMATQKKIIHGASSDSQDG-----------NIAEAKKSNADFRKFLM 2496
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+  D   ++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E S  V+     + E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RA+RN   ++ LW  Y+  ME +      I  TF           T ++ +WQAYLD+ +R++D +   + +L  +R  F + +      +E   +   DP C +++ W  IEA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   +                P+KR            D +    K ++V+ S   + ET             A+V +E P ++ E+                    T+FVSNL YS+ E D  LR  FE CG++ +IR    +    RG+ +++F  + +  +AL+++R+ +  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + +I+V +S PP ++ P+K           K P G  ++P+T G          L P A Q+     A+  +++G                K SNADF K  +
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFE-SAIVEAA---RLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTS-LEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETR-------KAPGGPMLLPQTYGARGKGRTQLSLLPRALQRP--SAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFL 961          

Query:  142 MKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD---KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK-------------SPFVDDGS-NEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK-------------EEAENPTK----------------PQKRKT---------PDYKSSGLKAKKVKFSEELSTETVT-----------ASVSIEQPIERCEEK-------------------TIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIG--MIPRTVG----------LKPMATQKKIIHGASSDSQDG-----------NIAEAKKSNADFRKFLM 2496
            ++I+   E +  N  DY+ H  LI  L+   ++ + R +R+ M   +PL+ E+W++W++DE S+  D   ++ +  +F +A++DY   ++W EY Q+ +G +  K   E++R  FE A++ VG H+TKG  +W  Y  +E              SPF  + + + Q E+++ ++ RQL++ L   + T  E+             +   +  + Q+L  Y P+E+ +   E    A               EY  Y +      + ++I+++  +ERA+ + CL  ++WI Y +YL +   + ++ +L  + RA+RN   ++ LW  Y+  ME +      I  TF           T ++ +WQAYLD+ +R++D +   + +L  +R  F + +      +E   +   DP C +++ W  IEA+   NM K+RELW  IM       +++WLE    ER  GD +H ++  + AV C +DYPE++CE +L +   E  L+ +    +K +T+  +++E+RMK             E+AE   +                P+KR            D +    K ++V+ S   + ET             A+V +E P ++ E+                    T+FVSNL YS+ E D  LR  FE CG++ +IR    +    RG+ +++F  + +  +AL+++R+ +  RPMFVS C   +K+     F YS   +E +KLF+  LP + TK  LE I K  G +K++RLVT ++G PKG+AYVEY NE+ AS+A++  DGM I + VI+V +S PP ++ P+K           K P G  ++P+T G          L P A Q+     A+  +++G                K SNADF K  +
Sbjct:   96 LEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARPVAGFLSPFDREQTFDSQLEKVHSLFRRQLAIPLYDMEATFAEY--EEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLA---------------EYQAYIDFEMKIGDPARIQLI--FERALVENCLVPDLWIRYSQYLDRQL-KVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAPGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDAKLRPLFEACGEVVQIRPIFSNRGDFRGYRYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTS-LEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENVIKVAISNPPQRKVPEKPETR-------KAPGGPTLLPQTYGARGKGRTQLSLLPRALQRP--GAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFL 979          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSIN---SDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYE-------KSPFVDDGSNEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ----------CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            AEI +++   E +  N  DY+ H  LI  L+   K+   R++R+ M   +PL+ E+W+DW+ DE  I    SD++ +  +F RAI+DY   ++W EY Q+ +G +  +   E +R  FE A+  VG H+TKG  IW  Y  +E       + P     S EQ+E       RI+ ++ RQL++ L   + T  E+   +  +      +  ++  + Q++    P+E+ +            S+ P+  E       +  E + ++++I+  +ERA+ + CL  ++WI Y  YL +   + ++ +L A++RAVRN   ++ LW  Y+  +E +      ++  F           T ++ +WQ+YLD+ +R++D   + + +L  +R  F + +    Y+  D +          C+L++ W  IEA +  NM K+RELW  IM       +++WLE    ER +GD  H ++  + AV C +DYPE++C+ +L     E  L+ +    +K +T+  ++ E+R +
Sbjct:   58 AEIQRLE---EQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRITEDESDREKVYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIWEAYREFEIVILSTVQPPPGTVPSQEQQELLSAQLERIHTLFRRQLAVPLMDMEGTYAEY--SDWADDGVPETVTHQYRRALQQMEKGKPYEEALL----------VSEPPKLAEYQSYIDFEIKEGDPARVQII--FERALAENCLVPDLWIKYTTYLDRQL-KIKDLVLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYLRRRVDFSKEWSRELDELRAAFSRSL---EYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKARELWDSIMTKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAVQCTSDYPEHVCDVLLNFERVEGSLEDWDAAVQKTETKLNRVCEQRAR 562          

Query: 1765 ERCEEKTIFVSNLKYSVN--ENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPP-------------IGMIPRTVGLKPMATQK------KIIHGASSDSQDGNIAEAKK-SNADFRKFLM 2496
            +R +E  +FVSNL +++   E  LR  F+ CG I ++R    +    RG+ ++QF+ +  V EALK++R+ +  RPM+VS C   NK+     F Y   + E +K+F+  LP + TK  LE++ K+ G ++ IR+VT +SG  KG+AYVE+ +E  AS+A++  DG  + +  + V +S PP +    KD  + S+ +    P             I ++PR++  +     K         H   +D +     + K  SN DF + L+
Sbjct:  683 QRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTFRGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSM-EKHKIFISGLPYSATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAISNPPGRRM--KDEAAPSRFLGAAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAKAENGTISAPHATVTDGETSLDTQTKSLSNEDFARMLL 949          

Query:  277 YYPLSPEMWIDWINDEKSINSDKDF--IRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEE------IRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQ-----KERIYKIYLRQLSLSLQSNDET----------LKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIEN---YIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDY---KSSGLK--AKKVK-----FSEELSTET----------------VTASVSIEQPIERCEE-KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK--SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSS--QSIDFKPP-------IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            + PL+P  W +WI D ++   +     +  +F +A+ D   V +W E   +      DK +       R     A+  +GT    G  IW  +L YE S ++ +  N        ++++ ++ R L       ++            K+  +  +  K + + +  K +LSK        FE+ I   ET             K+    ++  + + +     I   +ER +++L   +  WI+Y  +     +  +  + K Y RA+R+   S  L    +   E      +EI   +       +N       L++ Y    +R++      + D + + E+FD+   +      + +D      +   +  A    NM K R +W+ I+ S     +  W+E +  ER+FGD E+ ++  N A+N  +D    +    ++   EE  L       +K+++Q    + R  K+ +E P  P  +   D+   ++SG +   KKVK     F   L                       S ++++     E+ +TIFVSNL ++  E+++RQ  E    +A IR  + ++     RGFA++  ++    ++AL  +R  +  RPMF+S  +   +  F +S   +E +K+FV+N+    T   L+ +F +FG +  +R VT K G PKGIA+V++  E  A K +   D + + +R +EV LS PPVK+  K  G+ ++   S++   P       + ++PR +  K      ++    + D  +G       SN  FRK  M
Sbjct:   65 WAPLNPLNWKNWIEDFQNRKPEPSVAEVEEMFEKALFDENDVTIWVERAMYAYKVANDKNKKEDFKFCRDVCSKALENLGTRYDSGGHIWLIFLEYEMS-YLKNSMNAPDYQRLADQVFALFERALHCPTDQLEDVYVLAEQFCTEFKQHHKLEELKKTYNSTMRQKEQLSK--------FEELIQQEET-------------KKQGLKQFFDHEKKSGIPSRIKMAHERLVSELDDDEEAWIAYGAWADIELKLPQVAV-KVYSRALRHCPYSFVLHQQALLAFERDRRPNEEIDALWERARSNVINSAEEGRSLYRTYAFLLRRRI--HLTGSSDYSPMAEVFDEGAALLREWFSMAWDTTADYRQMQAYFYASLMKNMDKCRNIWNDILASGFGRFAGKWIEAVRLERQFGDKENARKYLNKALNSVSDNINEIYMYYVQFEREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPA-PAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEG---VASIRFARKANSDLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFST-TLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKDGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKD-KSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARL---DAMDVSEGTSTSQPLSNDQFRKMFM 834          

Query:  148 IDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSD----KDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEI---RQFFEVAIAQVGTHLTKGYLIWGTYLIYEK--------------SPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYL----PFEDKIANIETEYAANATSDSPESKEMHWIEYLKY--FE---SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDY-----DPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSN-SSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEE--------------------SDLKTYLQFTKKIDTQRKK------------ISERRMKEEAENPTKPQKRKT------------------------------PDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC----NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESP--------------KKDGESSSQSIDFKPPIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKK-----SNADFRKFLM 2496
            I   RE + +NP  YD+H ++I  LK S ++ + RE+RE M  Y+PL+ E+W+DWI DE  +  D    +D I  +F RA++DY+SV +W EY QF +G + D   I   R+ FE AI  VG H+T+G ++W  Y   E               +P  ++  N Q +R+  ++ RQL++ L   ++T  E+            ++    E S QK + +L    PFED +   E+ Y               W EY  Y  FE    + S+I+ +  +ER+IT+ CL+   W+ Y KYL     + +  IL  Y+RAVRN   S  LW  Y+  +E +N S ++++              + +  +W  Y+D+ +RQ++        L + RE  +K   +EN  +Y     D    + +YW  IE K   NM ++RE+W+ IM  LG  N +++WLE  + ER +GD +H ++L   A+N  TD+PE + +  +    EE                    +D K      +++ TQ+KK              +   KE    P KP K+                                P YK      KK K  EE +TE V    S +       ++T+FVSNL + +NE+ +++ F KCG+I+EIR+ K+ H KS+G+A+++F  +  V +AL+L+R+ +  RPM+VSRC        K  F +S  + E NKLF+KNLP   TK AL  IF Q G LK++R++T++SG PKG+AYVEY +E DA +A++ TDG++IGD  IEV +S PP ++ P              KK+ E+  ++   +  I ++PR V   P+  +      +++ S++G   ++       SN+DFR  L+
Sbjct:   25 IAQLREKINENPYLYDNHTEIIKLLKSSGELEKLREARENMSKYFPLTAELWLDWIKDEIRMIEDDFKDRDNIYQLFSRAVQDYQSVPLWLEYVQFAIGGMKDDGGISKMRKIFEEAITVVGLHVTQGSMVWDAYRETENAVLAGLLPAPGSIPTPEQEESFNVQNQRVSSLFKRQLAVPLLDMEQTYSEY------KDWNGGDLDIYTEESYQKSLAHLEKLKPFEDSLVTAESPY---------------WEEYQTYINFELKGDDPSRIQCI--FERSITENCLNPEAWLKYTKYLDSKL-KIKSVILPVYERAVRNCPWSCLLWQRYLLALERHNESGNKLKDVTAKALTSGFTLASEYSTIWSTYIDYLRRQINWSEDHTEQLELFRETIEK--ALENLTEYFGNDGDENGMMRQYWAVIEGKMCKNMTRAREIWNEIM-GLGYGNQANMWLEYYKLERAYGDNKHCRKLLQKALNSVTDWPESITQAYINFEREEGTLEDYDVAVGRCEAQLDRLTDRKAKAAEKEEVATQQKKQVRNEKKAQKKFEKKTPKKEVMTPPEKPAKKSPNNKRKLEEPNSTTSSISKQDKADDFRVPPPPGYKGEPPPNKKQKTEEETTTEGVKHDPSKD-------DRTVFVSNLNFDINEDGIKEIFCKCGEISEIRLVKNFHGKSKGYAYVEFIDELPVTKALELDRQPVHNRPMYVSRCEDRGGGKKKAEFRFSTDL-EKNKLFIKNLPFTCTKDALTTIFSQHGKLKDVRIITYRSGQPKGLAYVEYESEEDAKQAVLKTDGLQIGDHHIEVAISNPPARKQPVIKRDEFIPSLGGGKKESETRGKA---RTQIALLPRAVQKVPVPKKPTRPSASATASKNGGSGDSSAPPTAMSNSDFRNMLL 890          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINS---DKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYL-TDKE---EIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK------SPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEF----LXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKD-NVDLTIIRELFDKL---ITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTY----LQFTKKIDT-------------------QRKKISERRMKEEAE------NPTKPQKRKT---PDYKSSGLKAKKVKFSEELSTETV---------TASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC--NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKP------PVKESP---KKDGESSSQSIDFKPP---IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            NP DY SH  LIN L+   ++   R +RE M   YPLSP++W+ W+ DE  + +    K  +  +  RA++DY +V+VW EY QF +G + T+K+    +R  FE A+  VG H  KG +IW  +  +E        P       EQ ERI  ++ RQL+  L   ++T +E+         E    +  I   +  +  KL   LP+E+KI + +TE   N   DS       +  YL Y + N     I  LYERAITDL L  +IW+ YLKYL ++  + E  + + YQRA+RN     ++W  ++R  E +N SV E++T          +    +  LW  YL++ +R++D+ S D    L I+R  F++    +     ++ DP C +++YW   EA +A NM K+R LW+ I+    +  +S WLE I  ER +GD +HL++L   A+    D+PE +    +    +E  L+      ++  +K+D                    Q KK  +R+  E  +      +PTK  K +    P  + S L  +K   SEE   +T             + I+   E  ++ T+F+SNL Y+ +E ++R   +  G I   ++ +D   +S+G+ ++Q  +   +++AL+L+R  +  RPMFVS+C  N +    F YS  + E NKLFVK LP + TK  LE IFK  GALKE+R+VT+++G  KG+AYVE+ +EN A+KAL+ TDGM+I D+VI V +S+P      P  E P   K  G ++     F  P   + M+PRTV  K  AT     +G+++ S  GN    K +N DFR  L+
Sbjct:   78 NPYDYASHVALINKLQKMGELERLRAAREDMSSKYPLSPDLWLSWMRDEIKLATTIEQKAEVVKLCERAVKDYLAVEVWLEYLQFSIGNMGTEKDAAKNVRHLFERALTDVGLHTIKGAIIWEAFREFEAVLYALIDPLNQAERKEQLERIGNLFKRQLACPLLDMEKTYEEYEAWRHGDGTEAVIDDKIIIGGYNRALSKLNLRLPYEEKIVSAQTE---NELLDS-------YKIYLSYEQRNGDPGRITVLYERAITDLSLEMSIWLDYLKYLEENI-KIESVLDQVYQRALRNVPWCAKIWQKWIRSYEKWNKSVLEVQTLLENALAAGFSTAEDYRNLWITYLEYLRRKIDRYSTDEGKQLEILRNTFNRACEHLAKSFGLEGDPNCIILQYWARTEAIHANNMEKTRSLWADILSQGHSGTASYWLEYISLERCYGDTKHLRKLFQKALTMVKDWPESIANSWIDFERDEGTLEQMEICEIRTKEKLDKVAEERQKMQQMSNHELSPLQNKKTLKRKQDETGKWKNLGSSPTKITKVEMQIKPKIRESRLNFEKNTDSEEQKLKTAPPPGFKMPENEQMEIDNMHEMDDKSTVFISNLDYTASEEEVRNALQPAGPITMFKMIRDYKGRSKGYCYVQLSNMEAIDKALQLDRTPIRGRPMFVSKCDPNRTRGSGFKYSCSL-EKNKLFVKGLPVSTTKEELEEIFKVHGALKEVRIVTYRNGHSKGLAYVEFKDENSAAKALLATDGMKIVDKVISVAISQPPERKKVPATEEPLLVKSLGGTTVSRTTFGMPKTLLSMVPRTV--KTAAT-----NGSANVS--GNGVAPKMNNQDFRNMLL 905          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINS---DKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYL-TDKE---EIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEK------SPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEF----LXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKD-NVDLTIIRELFDKL---ITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTY----LQFTKKIDT-------------------QRKKISERRMKEEAE------NPTKPQKRKT---PDYKSSGLKAKKVKFSEELSTETV---------TASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC--NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKP------PVKESP---KKDGESSSQSIDFKPP---IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            NP DY SH  LIN L+   ++   R +RE M   YPLSP++W+ W+ DE  + +    K  +  +  RA++DY +V+VW EY QF +G + T+K+    +R  FE A+  VG H  KG +IW  +  +E        P       EQ ERI  ++ RQL+  L   ++T +E+         E    +  I   +  +  KL   LP+E+KI + +TE   N   DS       +  YL Y + N     I  LYERAITDL L  +IW+ YLKYL ++  + E  + + YQRA+RN     ++W  ++R  E +N SV E++T          +    +  LW  YL++ +R++D+ S D    L I+R  F++    +     ++ DP C +++YW   EA +A NM K+R LW+ I+    +  +S WLE I  ER +GD +HL++L   A+    D+PE +    +    +E  L+      ++  +K+D                    Q KK  +R+  E  +      +PTK  K +    P  + S L  +K   SEE   +T             + I+   E  ++ T+F+SNL Y+ +E ++R   +  G I   ++ +D   +S+G+ ++Q  +   +++AL+L+R  +  RPMFVS+C  N +    F YS  + E NKLFVK LP + TK  LE IFK  GALKE+R+VT+++G  KG+AY+E+ +EN A+KAL+ TDGM+I D++I V +S+P      P  E P   K  G ++     F  P   + M+PRTV  K  AT         S +  GN    K +N DFR  L+
Sbjct:   80 NPYDYASHVALINKLQKMGELERLRAAREDMSSKYPLSPDLWLSWMRDEIKLATTIEQKAEVVKLCERAVKDYLAVEVWLEYLQFSIGNMGTEKDAAKNVRHLFERALTDVGLHTIKGAIIWEAFREFEAVLYALIDPLNQAERKEQLERIGNLFKRQLACPLLDMEKTYEEYEAWRHGDGTEAVIDDKIIIGGYNRALSKLNLRLPYEEKIVSAQTE---NELLDS-------YKIYLSYEQRNGDPGRITVLYERAITDLSLEMSIWLDYLKYLEENI-KIESVLDQVYQRALRNVPWCAKIWQKWIRSYEKWNKSVLEVQTLLENALAAGFSTAEDYRNLWITYLEYLRRKIDRYSTDEGKQLEILRNTFNRACEHLAKSFGLEGDPNCIILQYWARTEAIHANNMEKTRSLWADILSQGHSGTASYWLEYISLERCYGDTKHLRKLFQKALTMVKDWPESIANSWIDFERDEGTLEQMEICEIRTKEKLDKVAEERQKMQQMSNHELSPLQNKKTLKRKQDETGKWKNLGSSPTKITKVEMQIKPKIRESRLNFEKNADSEEQKLKTAPPPGFKMPENEQMEIDNMNEMDDKSTVFISNLDYTASEEEVRNALQPAGPITMFKMIRDYKGRSKGYCYVQLSNIEAIDKALQLDRTPIRGRPMFVSKCDPNRTRGSGFKYSCSL-EKNKLFVKGLPVSTTKEDLEEIFKVHGALKEVRIVTYRNGHSKGLAYIEFKDENSAAKALLATDGMKIADKIISVAISQPPERKKVPATEEPLLVKSLGGTTVSRTTFGMPKTLLSMVPRTV--KTAATN-------GSANVPGNGVAPKMNNQDFRNMLL 907          

Query:  169 VLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINS---DKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK-EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFV----DDGS---NEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLD-KQSKDNVDLTIIRELFDKLI-----TIENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKE---------------EAENPTKP-------------QKRKTPDYKSSGLKA------KKVKFSEELS-----------------------------TETVTASVSIEQPIERCEEKTIFVSNLKYSVN--ENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNK----HSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKE-SPKKDG--------------------------------ESSSQSIDFKPPIGM------IPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFL 2493
            V  NP DY SH +LI AL+   ++ + R++RE M  ++PL+ E+W++W+ DE  ++S   ++  I  +F RA++DY   DVW EY Q+ +G + D  E +R   E A+   G H++KG ++W  Y  +E +       D GS    +Q+E       RI  I+ RQLS+ L   D T  E+     +    +  +   ++ + +KL  Y PFE+ +           ++ +P  +E  ++ Y+ Y  +      I  ++ERA+ +  L   +W  Y  YL     +    +L A++RA RN   +  LW GY+  +E +    ++I+   +          + ++ LWQ Y D+ +R++D  +  ++  +  +R  + + +     +++ Y     DPQC+L + W  +EAKY  NM K+RELW  IM       + +WLE  E ER +GD E  +++   AV+  +D+PE +CE ++    EE  L+TY     + + Q K++ ERR K+               EA    +              QKRK       G KA      K+VK    LS                               + T  V +  P    E +++FVSNL YS++  ++ +R+ F +CG++A++R+   S  K RGF +++F  +S   +AL  + + +  RP+FVS C    K    H F Y+  + E NKLFV NLP  VTK ALENIFKQ G L+ +R+VT++SG PKG+AYVEY +E  AS+A++ TDG+ IGDR I+V +S PP +   P  +G                                 ++S +   KPP G        P T G +P  TQ+ +  GA            + +NADF K  
Sbjct:   44 VSGNPYDYSSHVELIRALRREGELEDVRQARERMSKFFPLTEELWLEWLTDEMKLDSGRQNRTGINQLFERAVKDYLCADVWLEYIQYCIGGMEDGLEPVRAVCEKALTAGGLHVSKGTMLWDVYREFENAVLAGMQPDPGSICTGDQEEKIQAQISRINSIFRRQLSVPLLGMDGTYLEY--EEFQTGPVDATVKQVYQKACEKLDKYKPFEESLT----------SATAPRLQE--YLAYIDYELAEDEPTRIQCIFERALQENPLVVELWTKYTHYLDTKL-RIPHIVLSAHERATRNCPWAAILWQGYLLALERHRQPKEKIKEVMDTALPAGFPQASDYVSLWQTYCDYHRRRVDWTKDAESSGIDALRSTYQQAVDYCRDSLQQYFGETGDPQCTLQRTWARLEAKYNKNMGKARELWDGIMAEGHGREAQMWLEYAELERSYGDVERSRKVLQKAVSKASDWPESVCEALINFEREEGTLETYDNTVARCEAQLKRVQERRAKQAEKELVAAQAEEQKAEARKKNRAEKKSAKKQEMKQGQKRKVECLDEEGFKAPEEPPVKRVKGQCHLSQLLKGNSDEPEEVPFSAAWQSIHEATIPPVPSSTGDVPVHDPDR--ERRSVFVSNLSYSLHNPQDKMREVFSECGEVADVRLAFTSKKKFRGFCYVEFKEESAAVKALGFDHKEVEGRPLFVSPCIDKRKGDKFHGFQYATKL-EKNKLFVSNLPYTVTKEALENIFKQHGPLRGVRMVTYRSGKPKGLAYVEYEDEQTASQAVLKTDGLMIGDRKIQVAVSNPPTRRGGPHGEGVDDRLSRSDNKESQYRGKGRTQLSLLPRSLHKPTTSSASTSKPPAGSNGTTADQPATSG-QPTTTQEPVKQGAK-----------RLTNADFAKMF 922          

Query:  166 NVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINS---DKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYL-TDKE---EIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPF-VDDGSNE-----QKERIYKIYLRQLSLSLQSNDETLKEFLX----XXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQS-KDNVDLTIIRELFDKL---ITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTY----LQFTKKID------------------TQRKKISERRMKEEAE------NPTKPQKRKT---PDYKSSGLK-AKKVKFSEELSTETVTASVSIEQP------IERCEE----KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC--NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKES--------PKKD-GESSSQSIDFKPP---IGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            ++ +NP DY SH  LIN L+   ++   R +RE M+  YPLSPE+W+ W+ DE  + +    K  +  +  RA++DY SV+VW EY QF +G + T+K+    +RQ FE A+  VG H  KG +IW  +  +E   + + D SNE     Q ERI  ++ RQL+  L   ++T +E+                 +   ++ +  KL   LP+E+KI       +A A  +  +S +M    YL Y   +     I  LYERAITDL L  +IW+ YLKYL ++  + E  I + YQRA RN    +++W  ++R  E +  SV E++T          +    +  LW  YL++ +R++D+ S  +   L ++R  F++    +     ++ DP C +++YW   EA +A NM K+R LW+ I+    ++ +S WLE I  ER +GD +HL++L   A+    D+PE +    +    +E  L+      ++  +K+D                  +  KK  +R+  E  +      +PTK  K +T   P  + S L   KK+    E     +T     + P      IE   E     T+F+SNL Y+  E ++R   E  G I   ++ +D   +S+G+ ++Q +S   VE+AL+L+R  +  RPMFVSRC  N +    F YS   +E NKLF+K LP + TK  LE IF  +G LKE+R+VT+++G  KG+AYVE+ +EN A+KAL+ TDGM+IG++VI V +S+PP ++         P K  G ++     F  P   + M+PRTV         KI     S +  GN    K SN DFR  L+
Sbjct:   71 SLAENPYDYASHVALINKLQKMGELERLRIARENMNTKYPLSPELWLSWMRDEIKLATTPEQKAEVIKLCDRAVKDYLSVEVWLEYLQFSIGNMGTEKDAAKNVRQLFEQALTAVGLHTIKGAIIWEAFREFEAVLYALIDPSNEAERKEQLERIGNLFKRQLACPLLDMEKTYEEYEAWHNGDGAAATIDNKIVTGGYDRALSKLNLRLPYEEKIV------SAQAEKELLDSYKM----YLSYELQSGDPGRITVLYERAITDLSLEMSIWLDYLKYLDENI-KIESIIDQVYQRASRNVPWCVKIWQRWIRSYEKWGKSVLEVQTLLENALSAGFSTADDYRNLWITYLEYLRRKIDRYSDSEEKQLDVLRNAFNRACEHLAKSFGLEGDPNCIILQYWARTEAIHANNMEKARSLWADILSQGHSAIASYWLEYISLERCYGDTKHLRKLFQKALTSVRDWPESIANSWIDFERDEGTLEQMEICEIRTKEKLDKVAEERQKAPQMSNSELLSLNKKAHKRKQDESGKWKNLGGSPTKITKVETQIKPKIRESRLNLEKKINADVEEQRTKITPPPGFKTPENEKMEIENMHEVDDKTTVFISNLDYTATEEEVRNALEPAGPITMFKMIRDYKGRSKGYCYVQLNSVEAVEKALQLDRTTIKGRPMFVSRCDPNRTKGSGFKYS-NTLEKNKLFLKGLPLSTTKDELEEIFNVYGILKEVRIVTYRNGHSKGLAYVEFEDENSAAKALLATDGMKIGEKVISVAISQPPERKKIPATEELFPIKSLGGTTVSRSTFGMPKTLLSMVPRTV---------KIAATNGSANVTGNGVAPKMSNQDFRNMLL 903          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSIN----SDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYE-------KSPFVDDGSNEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMH-WIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQ----------CSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMK 1620
            AEI +++   E +  N  DY+ H  LI  L+   K+   R++R+ M   +PL+ E+W+DW+ DE  +     S+++ I  +F +A++DY   D+W E+ Q+ +G +  +     +R  FE A+  VG H+TKG  +W  Y  +E       + P     S EQ+E       RI+ ++ RQL++ L   + T  E+   +   +     +   ++ + Q L    P+E+ +            S+ P+  E   +I+Y +  E + ++++I+  +ERA+ + CL  ++W  Y  YL +   + ++ +L  ++R VRN   ++ LW  Y+  +E +      +   F           T ++ +WQ++LD+ +R++D   + + +L  +R  F + +   +Y+  D +          C++++ W  IEA +  NM K+RELW  IM       +++WLE    ER +GD  H ++  + AV C TDYPE++CE +L     E  L+ +    +K +++  +++E+R+K
Sbjct:   78 AEIQRLE---EQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRLTEGEESEREKIYELFEKAVKDYICPDIWLEFAQYSIGGMGAEGGISRVRSIFERALTAVGLHMTKGAALWEAYREFEIAILSTLQPPPGSVLSGEQQEQLNAQLERIHTLFRRQLAIPLLDMEGTYAEY--SDWAEEGVPEMVTQHYKRAAQHLEKSRPYEEALL----------VSEPPKLAEYQGYIDY-EMKEGDPARVQII--FERALAENCLVPDLWAKYTTYLDRQL-KIKDLVLSCHERGVRNCPWTMGLWKSYLLALERHGAEHHIVSDVFEKALNAGFIQATDYVEIWQSHLDYLRRRVDFSKEGSRELEELRSAFSRCL---DYLKQDVEERFSESGDLSCTIMQVWARIEALHCKNMQKARELWDSIMTKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAVQCTTDYPEHVCEVLLTFERVEGSLEDWDVAVQKTESRLNRVNEQRVK 583          

Query: 1651 KRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQK--FEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSI--------------DFKPPIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKK----SNADFRKFLM 2496
            +R  P  K+     +K   +++   E+    +S   P +R +  ++FVSNL +++ E + + K  F  CG + E+R    +    RG+ ++QF+ +   +EALKL+R  +  RPM+VS C   +K+     F Y+  + E +K+F+  LP   TK  LE + K+ G +K +RLVT ++G  KG+AYVE+ NE  AS+A++  D  +I +  + V +S PP +   K +G   S  +                +  + ++PR++  + +  + K  +G ++  QDG I + +     SN DF + L+
Sbjct:  670 RRAPPPRKAEPPAPRK---NQQAIPESAVRKISDIPPEQRKDSSSVFVSNLSFTMEEPEAKMKAVFNACGTVVEVRPVYTAKGAFRGYCYVQFEDELAAQEALKLDRVEVDARPMYVSPCVDKSKNPDSKIFKYNTSM-EKHKIFISGLPYTYTKEQLEELCKEHGGIKAVRLVTNRAGKSKGLAYVEFENETQASQAVLKMDRTKIENFTLSVAISNPPAR---KTEGSLGSGRVLGSMMPRQLQGARGKGRTQVSLLPRSLHRQSVP-EAKTENGTTAKQQDG-ITDGQGTKSLSNEDFARMLL 966          

Query: 1750 IEQPI-----ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC----NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            I QPI     E  + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+I+F   ++V  A+ L  + LL  P+ V       N +   + +   G     +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ +++   A KAL   +G E+  R ++V 
Sbjct:  140 IRQPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSAVGKVRDVRMISDRNSRRSKGIAYIEFVDSTSVPLAIGLSGQRLLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIDSIQLMMDTETGRSKGYGFITFADAECAKKALEQLNGFELAGRPMKVG 326          

Query: 1750 IEQPI-----ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYS----VGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            I QPI     E  + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+I+F   ++V  A+ L  + LL  P+ V    +    + + +     G     +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ +++   A KAL   +G E+  R ++V 
Sbjct:  103 IRQPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSAVGKVRDVRMISDRNSRRSKGIAYIEFVDSTSVPLAIGLSGQRLLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIDSIQLMMDTETGRSKGYGFITFADAECAKKALEQLNGFELAGRPMKVG 289          

Query: 1750 IEQPI-----ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC----NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            I QPI     E  + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+I+F   ++V  A+ L  + LL  P+ V       N +   + +   G     +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ +++   A KAL   +G E+  R ++V 
Sbjct:  125 IRQPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSAVGKVRDVRMISDRNSRRSKGIAYIEFVDSTSVPLAIGLSGQRLLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIDSIQLMMDTETGRSKGYGFITFADAECAKKALEQLNGFELAGRPMKVG 311          

Query: 1750 IEQPI-----ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSV-----GVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            + QPI     E  + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+++F   S+V  A+ L  + LL  P+ V + + + K+  + ++     G     +L+V +L  N+T+  L  IF+ FG ++ I+L+   ++G  KG  ++ +++   A KAL   +G E+  R ++V 
Sbjct:  178 VRQPIDNLSAEERDSRTVFCMQLAARIRPRDLEEFFSAVGKVRDVRMISDRNSRRSKGIAYVEFVEASSVPLAIGLTGQRLLGVPIIV-QASQAEKNRAAAALQNLQKGGAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFISFADAECAKKALEQLNGFELAGRPMKVG 364          

Query: 1741 SVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVE-----ANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            S S   P ER + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+I+F    +V  A+ L  + LL  P+ V    +    + + +   ++       +L+V +L  N+T+  L  IF+ FG +  I+L+   ++G  KG  ++ +S+ + A KAL   +G E+  R ++VN
Sbjct:  162 STSTLTPEER-DSRTVFCMQLAARIRAKDLEEFFSAVGKVRDVRLISDRNSRRSKGIAYIEFVDLDSVPLAIGLTGQRLLGVPIIVQASQAEKNRAAAAAAANLQKLASGPMRLYVGSLHFNITEAMLMGIFEPFGKIDNIQLMMDPETGRSKGFGFITFSSADCAKKALEQLNGFELAGRPMKVN 346          

Query: 1768 RCEEKT-IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSN------KHSFSY----SVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            R +E T +++ N    ++E+ LR+ F K GK   + +  D   KSRGF F+ F    D+Q  V    ++  + L  R +FV R           K  F       +   +   L+VKNL  N+    L   F  +G +   ++++ + G  KG  +V +S+  +A+KA+   +G  +G + + V L++
Sbjct:  189 RAKEFTNVYIKNFGDDMDEDKLREFFGKFGKALSVCVMSDECGKSRGFGFVSFEQHEDAQRAV---NEMNGKELNGRTVFVGRAQKKGERQAELKRKFEMLKQERISRYQGVNLYVKNLDDNIDDEQLRKEFAPYGTITSTKVMS-EEGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQ 372          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQST----VXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            +F+ NL  S++   +   F   G I   ++  D  + SRG+ F+ F++Q      +E+   +     L R  FV R  S  +          E   +++KN   ++ +  L   F +FG    + +++ + G  +G  +V +    DA +A+   +G E+  R + V  ++
Sbjct:  101 VFIKNLDKSIDNKAMYDTFSAFGNILSCKVVCD-ENGSRGYGFVHFETQEAADRAIEKMNGMLLNDRLARRRFVGRFKSRKEREQEMGARAKEFTNVYIKNFGDDMDEDKLREFFGKFGKALSVCVMSDECGKSRGFGFVSFEQHEDAQRAVNEMNGKELNGRTVFVGRAQ 270          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDS-HDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRV 2265
            +++V +L   V E  L +KF   G +  IR+ +D    +S G+A++ F    D++  ++       +    R M+  R  S  K      VG V     F+KNL K++   A+ + F  FG +   ++V  ++G  +G  +V +  +  A +A+   +GM + DR+
Sbjct:   12 SLYVGDLHPDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKS----GVGNV-----FIKNLDKSIDNKAMYDTFSAFGNILSCKVVCDENG-SRGYGFVHFETQEAADRAIEKMNGMLLNDRL 167          

Query: 1780 KTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDK-SRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGV-VEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFK-SGLPKGIAYVEYSNENDASKALV 2232
            + +FV  L +   E  LRQ FE+ G + +  + KD+  K SRGF F+ F S S V+ A+      +  R +   R  S      S   G  +   K+FV  +  +  +  L + F+++G ++ + ++T + SG  +G A+V +++ +   K +V
Sbjct:   11 RKLFVGGLSFETTEEGLRQYFEQWGSLTDCVVMKDTQSKRSRGFGFVTFSSMSEVDAAMSARPHKIDGRMVEPKRAVSRED---SMRPGAHLSVKKIFVGGIKDDTDEEHLRDYFEKYGRIEIVEVMTERESGKKRGFAFVTFNDHDPVDKIVV 161          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFV-------SRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSID 2343
            P ER + +T+F   L   +   DL + F   GK+ ++R+  D +  +S+G A+I+F    +V  A+ L  + LL  P+ V       +R  ++   + +         +L+V +L  N+T+  L+ IF+ FG ++  +L+    +G  +G  +V +++   A KAL   +G E+  R ++V         + + DG  +S  +D
Sbjct:  153 PEER-DARTVFCMQLAARIRPRDLEEFFSAVGKVRDVRMISDRNSRRSKGIAYIEFVEVDSVSLAIGLTGQRLLGVPIIVQASQAEKNRAAAAAAAAATMQKSTAGPMRLYVGSLHFNITEDMLKGIFEPFGKIENCQLMMDSDTGRSRGYGFVTFADAECARKALEQLNGFELAGRPMKVG------HVTERSDGSGASSFLD 349          

Query: 1759 PIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKD-SHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFK-SGLPKGIAYVEYSN 2205
            P E  + + +F+  L +   E  LR+ +E+ G I +  + KD S  +SRGF FI +     V  A++     +  R +   R    +       V V    KLFV  +  N  +  L + F +FG ++ + +VT K +G  +G A+V + +
Sbjct:    7 PKEPEQMRKLFIGGLSFETTEESLREYYEQWGTIVDCVVMKDPSSKRSRGFGFITYSVMEEVNSAMQARPHTVDGRVVEAKRAVPRDDSRPGIQVTV---KKLFVGGIKDNTDESHLRDYFSKFGRVESVDMVTDKQTGKKRGFAFVTFDD 154          

Query: 1765 ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIR-IQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXX-XXRP----MFVSRCNSSNKHSFSYSVGVVE-ANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTF-KSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKP 2289
            E  E  TIFV  L +S+++  L+++FE  G +   R I +   D+SRG+ ++ F+++S  E+A++  +      RP    M  S+   +N  +  +     E ++ LF+ NL  N  + A+  +F + G +  +R+ T  ++  PKG  YV++SN  DA KAL    G  I +R + ++ S P
Sbjct:  163 ETEEPATIFVGRLSWSIDDEWLKKEFEHIGGVIGARVIYERGTDRSRGYGYVDFENKSYAEKAIQEMQGKEIDGRPINCDMSTSKPAGNNDRAKKFGDTPSEPSDTLFLGNLSFNADRDAIFELFAKHGEVVSVRIPTHPETEQPKGFGYVQFSNMEDAKKALDALQGEYIDNRPVRLDFSSP 345          

Query: 1765 ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKD-SHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFK-SGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKP 2289
            E C+   +F+  L +   E++LR+ F K G + +++I KD +  +SRGF F+ F+  S+V + +   + +L  + +   R    ++          +  K+FV  +  +V     E  F Q+G + + +L+  K +G  +G  +V Y +  DA   +     ++  DR IE+  ++P
Sbjct:  157 ESCK---MFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPSSV-DEVVKTQHILDGKVIDPKRAIPRDEQD--------KTGKIFVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSA-DAVDRVCQNKFIDFKDRKIEIKRAEP 320          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFD-SQSTVXXXXXXXXXXXXXRPMFVSRCNSSN-------KHSFSY---SVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALV 2232
             ++V N+     +   ++ F K G I    ++KD+  K +GF F+ ++  +  V+    L    L    ++V R    N       K   +Y    +   +   LFVKNL  +V    LE  F  +G +   +++  ++G  KG  +V +S   +A+KA+ 
Sbjct:  220 NLYVKNINSETTDEQFQELFAKFGPIVSASLEKDADGKLKGFGFVNYEKHEDAVKAVEALNDSELNGEKLYVGRAQKKNERMHVLKKQYEAYRLEKMAKYQGVNLFVKNLDDSVDDEKLEEEFAPYGTITSAKVMRTENGKSKGFGFVCFSTPEEATKAIT 380          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXX-XXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEI 2253
             IF+ NL   ++   L   F   G I   +I  D + KS+GF F+ F+ +   +EA   L   LL  + ++V+   S  +              L+VKN+    T    + +F +FG +    L     G  KG  +V Y    DA KA+   +  E+
Sbjct:  127 NIFIKNLHPDIDNKALYDTFSVFGDILSSKIATDENGKSKGFGFVHFEEEGAAKEAIDALNGMLLNGQEIYVAPHLSRKERDSQLEETKAHYTNLYVKNINSETTDEQFQELFAKFGPIVSASLEKDADGKLKGFGFVNYEKHEDAVKAVEALNDSEL 284          

Query: 1747 SIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKI--AEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXX-XXRPMFVSRCN---SSN-KHSFSYSVGVVEANK----LFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEV 2274
            + E+ + R    +IFV NL Y     DL + F + GK+  A+I   +  H   RG   ++F +   V+ A++       ++R +FV + N   S+N K   +   G +  N+    + VKNLP +V   AL++IFK+ G +    +     G+  G   V + +  D  +A+   +G  I   V++V
Sbjct:  150 TYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHH---RGMGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDV 333          

Query: 1777 EKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXX-XXRPMFVSRCNSSNKHSFSYSVGVV-----EANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEV 2274
            E +IFV NL +     DL++ F   G++ E  I   S    RG   ++F    +V++A+      L ++R + V + N   + +  +S            ++F+ NLP ++   +L+++FK+ G +    +    +G  +G   V Y  E++  +A+   +GME+  RV+EV
Sbjct:  121 ENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIIT-SKGHHRGMGTVEFTKNESVQDAISKFDGALFMDRKLMVRQDNPPPEAAKEFSKKATREEIDNGFEVFIINLPYSMNWQSLKDMFKECGHVLRADVELDFNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVEGRVLEV 291          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDE---KSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYL-TDK--EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDY------DPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERR----------MKEEAENPTKPQKRKTPDYKSSGLKA------------KKVKFSEELSTE----------TVTASVSIE------------------QPIERCEEKT-----IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC--NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVK 2298
            AEI ++++  E    NP +Y SH +LIN L  S  +   R++RE M   +PL+ E+W+ WI DE     I   ++ ++++F R ++DY+SV +W +YCQFM+  + TD+  E +R  FE A+   G H+T+   I  +         +      Q+ER+  IY RQL++ L     T+++F +W +E++E    +   ++ ++ KL   LP+ED++         +  S+S E+    +  YLKY       + I+ LYERA+ D CL  ++W+ Y  YL     +    +L A++RAVRN      LW  Y+  +E  N    +I+  F+       +    F+ LW+ Y +  +R++ + ++++ +   ++E  D L +   Y+ +      D    L + W  +EA    N+ +++ LW +++   G      W+E     R   D +  +++ + AV   +D PE     +L +  EE  L+ +     +  T+ K ++ERR          MKE  E   K +  +T    +   +             +KV+ S  LS            TV +   +E                  +P    EE++     +F+SNL +S+ E+ LR KF K G++ ++RI K+   +S+G+A+++F+++STV+ AL ++RE +  RPMF+S C   + N  +F +    ++ + LFV NLP +  +  +E +F + G +K++RLVT ++G PKG  YVEY  E+ AS A++  D  E+  R I V LS PP +
Sbjct:   11 AEIHQLEVQLET---NPYNYQSHIQLINLLSSSGDLERLRQARENMSKSFPLTEELWLSWIEDELPLACIPDHRETVKSLFDRGVQDYQSVKLWIQYCQFMMDNMETDQGLENVRATFEKALTSAGLHVTEVCTIGLSTF------RLTVCLAAQRERVESIYRRQLAVPLLGMQMTMRDFEDWLEEDEEVPVPVKLAYQKAETKLEEILPYEDEL--------NSNKSNSLEA----YKNYLKYEVQKGEPVRIVCLYERALKDNCLYSDLWMEYTTYLDSKL-KISSVVLPAHERAVRNCPWVASLWQNYMLALERSNQPSSKIKEIFDKALTCGFSSGVEFLQLWRCYCNHMRRRVKEWTEESHE---VKEWRDSLKSAIEYMQHYFGNEGDSTNLLDRCWARLEAYKLSNLSEAQRLWEIVISRHGR-ELEYWVEYANLVRTCKDVQSCRKVLHRAVQSVSDNPEGATRALLSLEEEEGSLEDWDSSYARCATRLKIVNERRTRAAEKEMSQMKEGEELAEKKKASRTEKKATKKQEKKAEKKDKAQTMKRKVRESYSLSPARNNITLHSLCTVYSQAGMEGSQNQQIDKVRSSEPAAKKPCGESEEESSDPRKVFISNLLFSITEDHLRDKFSKLGEVLDVRIVKNMAGRSKGYAYVEFNNESTVQAALAMDREKMEGRPMFISPCVDKAKNPTTFKFPTS-LDKHTLFVSNLPFDAKESEIEELFSKHGVVKQVRLVTNRAGKPKGYGYVEYEQESSASTAVLTLDKTEVKGRTISVALSNPPTR 774          

Query:  178 NPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDE---KSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYL-TDK--EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKS 549
            NP +Y SH +LIN L  S  +   R++RE M   +PL+ E+W+ WI DE     I   ++ ++++F R ++DY+SV +W +YCQFM+  + TD+  E +R  FE A+   G H+T+G  IW  +  +E +
Sbjct:    4 NPYNYQSHIQLINLLSSSGDLERLRQARENMSKSFPLTEELWLSWIEDELPLACIPDHRETVKSLFDRGVQDYQSVKLWIQYCQFMMDNMETDQGLESVRATFEKALTSAGLHVTEGSSIWDGFREFETT 133          

Query: 1753 EQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGV---VEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLV-TFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQS 2337
            E+  E  +++T+F   L  ++   DL + F K G+++++RI  D +  +S+G A+I+F  +S V  A+ L  + LL  P+ V    +      + +  +   +   +L+V +L  N+T+  ++ +F+ FG +  ++L+   ++   KG  +V++     A +A+   +G E+  R +++     PV E     G+SS+ S
Sbjct:  110 EESAEEKDQRTVFCMQLARNIRPRDLEEFFSKVGQVSDVRIISDRNSRRSKGIAYIEFTDKSAVPLAIGLSGQKLLGAPIMVMLTQAEKNRLAAEAERLKQPLGPTRLYVGSLHFNITEAMVKAVFEPFGTVDSVQLIYDSETNRSKGYGFVQFREAEAAKRAMEQMNGFELAGRPLKIG----PVTER----GDSSAYS 301          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKD-SHDKSRGFAFIQFD----SQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            +++V +L   V E  L +KF   G +  IR+ +D    +S G+A++ F     ++  ++       +    R M+  R  S  K              +F+KNL K++   +L + F  FG +   ++   + G PKG  +V +  E+ A +A+   DGM + D+ + V 
Sbjct:   14 SLYVGDLAPDVTEAMLYEKFSTAGSVLSIRVCRDLVTRRSLGYAYVNFQQPGHAEKALDTMNFDPIKGRPCRIMWQQRDPSLRKSGVG---------NIFIKNLDKSIDNKSLYDTFSAFGNILSCKIAQDELGNPKGYGFVHFETEDAALEAIARVDGMLLNDKKVFVG 174          

Query: 1768 RCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKAL 2229
            RC    +FV NL    +E ++++ F+K G++AE+ I     +K +GF FI+ D++   E A               +R   + +  F+       A  L VKNL   VT   LE  F QFG ++   +V    G  KG   VE+S +N+A  A+
Sbjct:    9 RC---RLFVGNL-IDCDEEEMKEMFKKYGEVAEVFI-----NKEKGFGFIRLDTRLHAEAAKAGLD--------MATRKGRTLRVRFA-----THAAALRVKNLDNLVTNELLEQAFSQFGDVERAVVVCDVRGRSKGHGIVEFSRKNNAHNAM 140          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYL---IWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLD-KQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERIL---RIVAEESDLKTYLQFTK----KIDTQRKKISERRMKEEAENPTKPQKRKTPDYKSSGLKAKKVKFSEELSTETV------------------------TASVSIEQPIE-RCEEKTIFVSNLKYSVNEND--LRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHS----FSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKP------------PIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKK----SNADFRKFLM 2496
            AEI +++   E +  N  DY+ H  LI  LK   ++I  R++R+ M   +PL+ E+W+DW+ DE  +  ++                               +++E++ + FE AI        K Y+   IW  Y  Y        G  ++   I++  +  + L +       + + E+          +    +L++ +   Y+ FE K+ +                                ++I+I   +ERA+ + CL  ++W    KYL +   + ++ +L  ++RAVRN   ++ LW  Y+  +E +      +   F           T ++ +WQ YLD+ +R++D K SK+   L  +RE F + +      +E       DP C +++ W  IEA +  NM K+RELW  IM    +  +++WLE    ER +GD  H ++  + AV C TDYPE++C+ +L   R+     D  T +Q T+    +I+ QR K +E+   +  +   + ++R+    +  GLK  +    E + TET                          A   I+   E R +  ++F+SNL +++ E +  L+  FE CG IA++R         RG+ ++QF+S ++V EALKL+R  +  RPMFVS C   NK+     F Y+  + E +K+F+  LP + TK  LE I KQ G +K++RLVT++SG PKG+AYVE+++E  AS+A++  DG+EI    I V +S PP +   +K G SS    D  P             + ++PR++  +  A   K+ +G +++  +G +    +    SN+DF K L+
Sbjct:   59 AEIQRLE---EQLSINAFDYNCHVDLIKLLKQEGELIRLRKARQKMSELFPLTEEIWLDWLKDEIRLTEEE-------------------------------SNREKVYELFERAI--------KDYICPEIWLEYAQYSIGGMGSPGGIDKVRSIFERAVTAVGLHMTKGQSVWEAYREFENAILSTLQLVAEPPKLAEYQA--YIDFELKVGDP-------------------------------ARIQIT--FERALAENCLVPDMWSKCTKYLDRQL-KVKDLVLSTHERAVRNCPWTMSLWKSYLLALERHGADHHTVSDVFEKALNAGFIQATDYVEIWQVYLDYLRRRVDFKSSKE---LEELREAFSRCLDYMKQDVEERFGESGDPSCVVMQIWARIEALHCKNMQKARELWDNIMTKGNSKYANMWLEYYNLERSYGDSVHCRKALHRAVQCTTDYPEHVCDVLLTFERVEGSLEDWDTAVQKTESRMNRINEQRAKAAEKEANQARQEEERVEQRRKVKAEKKGLKKDQRGADEYMETETGLFGRNAPRTKPSAGLKKVPPGHGDAAEKQIDDKSELRDDCCSVFISNLAFTLQEPEATLKALFESCGSIAQVRPIFGHRGVFRGYCYVQFESPASVTEALKLDRREVEGRPMFVSPCVDKNKNPDFKIFKYNTSL-EKHKIFISGLPLSCTKEQLEEICKQQGTVKDVRLVTYRSGRPKGLAYVEFADETQASQAVLKMDGVEIEGHKISVAISNPPRRSVNEKPG-SSRPVTDMMPRQNYGSRGKGRTQLSLLPRSLH-RQAAGVGKVENGTAAEKMEGTVNTTGEPRTLSNSDFAKMLL 827          

Query:  133 AEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSIN---SDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDK---EEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKS-------PFVDDGSNEQKE-------RIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFE-----SNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLIT-----IENYID--YDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERIL---RIVAEESDLKTYLQFTK----KIDTQRKKISERRMKEEAENPTKPQKRKTPDYKSSGLKAKKVKFSEELSTET----------------VTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKS-------RGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC--NSSNKHSFSYSVGVVEANKL---FVKNLPKNVTKYALEN------IFKQFGALKEIRLVTFKSGLP-------------------------------KGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKP------------PIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKK----SNADFRKFLM 2496
            AEI +++   E +  N  DY+ H  LI  LK   ++I  R++R+ M   +PL+ E+W+DW+ DE  +    S+++ +  +F RAI+DY   ++W EY Q+ +G +      +++R  FE A+  VG H+TKG  +W  Y  +E +       P      NE++E       RI+ ++ RQL++ L   + T  E+             +  +++ + Q++    P E+ +   E    A               EY  Y +      + ++I+I   +ERA+ + CL  ++W    KYL +   + ++ +L  ++RAVRN   ++ LW  Y+  +E +      +   F           T ++ +WQ YLD+ +R++D   + + +L  +RE F + +      +E       DP C +++ W  IEA +  NM K+RELW  IM    +  +++WLE    ER +GD  H ++  + AV C TDYPE++C+ +L   R+     D  T +Q T+    +I+ QR K +E+   +  +   + ++R+    +  GLK  +    E+   E                      + ++ +E   E  +F  N   +     L++     G  AE +I   S  +           AF   + ++T++   +    +   RP+F  R          F     V EA KL    V+  P  V+    +N      IFK   +L++ ++  F SGLP                               KG+AYVE+++E  AS+A++  DG+EI    I V +S PP +   +K G SS    D  P             + ++PR++  +  A   K+ +G +++  +G +    +    SN+DF K L+
Sbjct:   59 AEIQRLE---EQLSINAFDYNCHVDLIKLLKQEGELIRLRKARQKMSELFPLTEEIWLDWLKDEIRLTEEESNREKVYELFERAIKDYICPEIWLEYAQYSIGGMGSPGGIDKVRSIFERAVTAVGLHMTKGQSVWEAYREFENAILSTLQPPPGKVPRNEEQELIKTQLERIHTLFRRQLAIPLMDMEATYAEY--EEWSEHGVPEAVAHQYKKALQQMEKCKPLEEALLVAEPPKLA---------------EYQAYIDFELKVGDPARIQIT--FERALAENCLVPDMWSKCTKYLDRQL-KVKDLVLSTHERAVRNCPWTMSLWKSYLLALERHGADHHTVSDVFEKALNAGFIQATDYVEIWQVYLDYLRRRVDFSKESSKELEELREAFSRCLDYMKQDVEERFGESGDPSCVVMQIWARIEALHCKNMQKARELWDNIMTKGNSKYANMWLEYYNLERSYGDSVHCRKALHRAVQCTTDYPEHVCDVLLTFERVEGSLEDWDTAVQKTESRMNRINEQRAKAAEKEANQARQEEERVEQRRKVKAEKKGLKKDQRGAGEKRKAEQEDQDEWNKDSGPKRRRGNVDGTTDEYME--TETGLFGRNAPRTKPSAGLKKVPPGHGDAAEKQIDDKSELRDDCCSVFISNLAFTLQEPEATLKALFESCGSIAQVRPIFGHRGVFRGYCYVQFESPASVTEALKLDRREVEGRPMFVSPCVDKNKNPDFKIFKYNTSLEKHKI--FISGLPLSCTKEQLEEICKQQGTVKDVRLVTYRSGRPKGLAYVEFADETQASQAVLKMDGVEIEGHKISVAISNPPRRSVNEKPG-SSRPVTDMMPRQNYGSRGKGRTQLSLLPRSLH-RQAAGVGKVENGTAAEKMEGTVNTTGEPRTLSNSDFAKMLL 937          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXX-XXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ NL  S++   L   F   G I   ++  D  + SRG+ F+ F++    E A  K+   LL +R +FV R  S  +          E   +++KN  +++    L+ IF +FG    +R++T +SG  +G  +V + N  DA KA+   +G E+  R++ V  ++
Sbjct:  101 IFIKNLDKSIDNKALYDTFSAFGNILSCKVVCD-ENGSRGYGFVHFETHDAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAREFTNVYIKNFGEDMDDEKLKEIFSKFGNATSVRVMTDESGGGRGFGFVSFENHEDAQKAVDEMNGKELNGRIMFVGRAQ 267          

Query: 1783 TIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDS-HDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            +++V +L   V E  L +KF   G I  IR+ +D    +S G+A++ F    D++  ++       +    R M+  R  S  K       GV     +F+KNL K++   AL + F  FG +   ++V  ++G  +G  +V +   + A +A+   +GM + DR + V 
Sbjct:   12 SLYVGDLHQDVTEAMLYEKFSPAGAIVSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGQPVRIMWSQRDPSLRKS------GV---GNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENG-SRGYGFVHFETHDAAERAIEKMNGMLLNDRKVFVG 171          

Query: 1768 RCEEKT-IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQF----DSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYS----------VGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            R  E T +++ N    +++  L++ F K G    +R+  D     RGF F+ F    D+Q  V+E    E      R MFV R     +                    +   L+VKNL   +    L   F  FG++   + V  + G  KG  +V +S+  +A+KA+   +G  +  + + V L++
Sbjct:  186 RAREFTNVYIKNFGEDMDDEKLKEIFSKFGNATSVRVMTDESGGGRGFGFVSFENHEDAQKAVDEMNGKELNG---RIMFVGRAQKKMERQMELKRRFEQMKQDRTTRYQGVNLYVKNLDDGIDDERLRKEFSPFGSITSAK-VMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQ 369          

Query: 1786 IFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXX-XXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSK 2286
            IF+ N+  S++   L   F   G I   ++  D    S+G+ F+ F++Q     A   +   LL +R +FV    S  +    +   V++   +++KN   N+T   L+  F  FG    +R++  + G  +G  +V Y++  DA KA+   +G E+  ++I V  ++
Sbjct:   76 IFIKNIDDSIDNKALYDTFSAFGNILSCKVVCDERG-SKGYGFVHFETQEAANRAIETMNGMLLNDRKVFVGHFKSRKEREVEFGTKVMKFTNIYIKNFGDNLTDEKLKEAFSAFGKTLSVRVMRDEKGRSRGFGFVNYAHHEDAQKAVDEMNGKEMNGKIIYVGRAQ 242          

Query: 1750 IEQPI-----ERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHD-KSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRC----NSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVT-FKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVN 2277
            + QPI     E  + +T+F   L   +   DL   F   GK+ ++RI  D +  +S+G A+I+F   S+V  A+ L  + LL  P+ V       N +   + +   G     +L+V +L  N+T+  L  IF+ FG ++ I+L+   ++G  KG  ++ +++   A KAL   +G E+  R ++V 
Sbjct:  135 VRQPIDNLTPEERDARTVFCMQLAARIRARDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYIEFVETSSVPLAIGLTGQRLLGVPIIVQASQAEKNRAAAAANNLQKGSAGPMRLYVGSLHFNITEEMLRGIFEPFGKIEGIQLMMDSETGRSKGYGFISFADAECAKKALEQLNGFELAGRPMKVG 321          

Query:  127 FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLXXXXXXXXXXXXICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVXXXXXXXXXXXXXRPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 2496
            FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLEWNQENKEWENEICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVEEALKLERELLLERPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM
Sbjct:   16 FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFLEWNQENKEWENEICAKHELSKQKLINYLPFEDKIANIETEYAANATSDSPESKEMHWIEYLKYFESNCSKIEILNLYERAITDLCLSQNIWISYLKYLSQHFEQDEERILKAYQRAVRNYKSSLELWIGYVRHMEMYNCSVDEIRTTFNLIFRQNLNDQTPFIPLWQAYLDFEKRQLDKQSKDNVDLTIIRELFDKLITIENYIDYDPQCSLVKYWTFIEAKYAGNMPKSRELWSLIMKSLGNSNSSLWLENIEFERKFGDFEHLKRLANTAVNCFTDYPEYLCERILRIVAEESDLKTYLQFTKKIDTQRKKISERRMKEEAENPTKPQKRKTPDYKSSGLKAKKVKFSEELSTETVTASVSIEQPIERCEEKTIFVSNLKYSVNENDLRQKFEKCGKIAEIRIQKDSHDKSRGFAFIQFDSQSTVEEALKLERELLLERPMFVSRCNSSNKHSFSYSVGVVEANKLFVKNLPKNVTKYALENIFKQFGALKEIRLVTFKSGLPKGIAYVEYSNENDASKALVGTDGMEIGDRVIEVNLSKPPVKESPKKDGESSSQSIDFKPPIGMIPRTVGLKPMATQKKIIHGASSDSQDGNIAEAKKSNADFRKFLM 805          

Query:  127 FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFL 660
            FSAEIMKIDMYRENVLKNPL YDSH KLINALKHSEKMIEARESRETMHIYYPLSPEM  DWINDEKSINSDKDFIRA+F+RAIEDY+SV VWFEY QFMLGYLT+K+EIRQ FEVAIAQVGTHLTKGYLIWGTYLIYEKS FVDDGSNEQK+RIYK+YLRQLSLSLQSNDETLKEFL
Sbjct:   16 FSAEIMKIDMYRENVLKNPLHYDSHWKLINALKHSEKMIEARESRETMHIYYPLSPEMRYDWINDEKSINSDKDFIRALFIRAIEDYRSVYVWFEYYQFMLGYLTNKKEIRQCFEVAIAQVGTHLTKGYLIWGTYLIYEKSLFVDDGSNEQKDRIYKLYLRQLSLSLQSNDETLKEFL 193          

Query:  127 FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFL 660
            FS EIMKIDMYRENVLKNPL YDSH KLINALKHSEKMIEARESRETMHIYYPLSPEM  DWINDEKSINSDKDFIRA+F+RAIEDY+SV VWFEY QFMLGYLT+K+EIRQ FEVAIAQVGTHLTKGYLIWGTYLIYEKS FVDDGSNEQK+RIYK+YLRQLSLSLQSNDETLKEFL
Sbjct:   16 FSVEIMKIDMYRENVLKNPLHYDSHWKLINALKHSEKMIEARESRETMHIYYPLSPEMRYDWINDEKSINSDKDFIRALFIRAIEDYRSVYVWFEYYQFMLGYLTNKKEIRQCFEVAIAQVGTHLTKGYLIWGTYLIYEKSLFVDDGSNEQKDRIYKLYLRQLSLSLQSNDETLKEFL 193          

Query:  127 FSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLK 651
            FSAE MKI MYRENVLKNPLDYDSH KLINALKHSEKMIEARESRE MHIYYPLSPEMWID INDEKSINS+KDFIRA+F+RAI+DY+SVD WFEYCQFMLGYLTDKEEIRQ FEVAIAQVGTHLTKGYLIWGTYLIYEKS FV DG NEQKERIYK+YLRQLSLSLQSNDETLK
Sbjct:   16 FSAESMKIYMYRENVLKNPLDYDSHWKLINALKHSEKMIEARESREIMHIYYPLSPEMWIDCINDEKSINSNKDFIRALFIRAIKDYRSVDAWFEYCQFMLGYLTDKEEIRQCFEVAIAQVGTHLTKGYLIWGTYLIYEKSSFVYDGINEQKERIYKLYLRQLSLSLQSNDETLK 190          

Query:   73 MFHMIXXXXXXXXXXXXXFSAEIMKIDMYRENVLKNPLDYDSHCKLINALKHSEKMIEARESRETMHIYYPLSPEMWIDWINDEKSINSDKDFIRAIFLRAIEDYKSVDVWFEYCQFMLGYLTDKEEIRQFFEVAIAQVGTHLTKGYLIWGTYLIYEKSPFVDDGSNEQKERIYKIYLRQLSLSLQSNDETLKEFL 660
            MFHMIDDDLSSSDSESEDFSA+IMKIDMYREN LKNPLDYDSH KLINALKHSEKMIEAR+SRETMHIYYPL PEMWIDWINDEKSINSDKDFI AI     EDY+SVDVWF+YCQFMLGYLTDKEEIRQ FEVA AQVGTHLTKGYLIWGTYLIYEKS FVDDGSNEQKERIYK+YLR+LSLSLQSNDETLKEFL
Sbjct:    1 MFHMIDDDLSSSDSESEDFSAKIMKIDMYRENFLKNPLDYDSHWKLINALKHSEKMIEARKSRETMHIYYPLFPEMWIDWINDEKSINSDKDFICAI-----EDYRSVDVWFKYCQFMLGYLTDKEEIRQCFEVAFAQVGTHLTKGYLIWGTYLIYEKSFFVDDGSNEQKERIYKLYLRKLSLSLQSNDETLKEFL 191