Transcription factor Sox-2

Overview
NameTranscription factor Sox-2
Smed IDSMED30001191
Uniprot Best hitTranscription factor sox-2 OS=Caenorhabditis elegans OX=6239 GN=sox-2 PE=1 SV=2 (E=1.13078e-38)
Length (bp)2941
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transcription factor Sox-2 (SMED30001191) t-SNE clustered cells

Violin plots show distribution of expression levels for Transcription factor Sox-2 (SMED30001191) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Transcription factor Sox-2 (SMED30001191) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Transcription factor Sox-2 (SMED30001191) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30001191

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neuronSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
neuronSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v6_8104_0_1dd_Smed_v6PMID:30399335
Ross et al., 2018
whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v6_8104_0_1dd_Smed_v6PMID:30399335
Ross et al., 2018
whole organism asexual adult colorimetric in situ hybridization evidence
Category 4 cellSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
dorsal region of the epidermisSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
ventral epidermisSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
dorsal region of the whole animalSMED30001191SMESG000067682.1 SMESG000060099.1 dd_Smed_v4_8104_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Match: SOX2 (SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195])

HSP 1 Score: 147.902 bits (372), Expect = 1.818e-38
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   40 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 117          
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Match: SOX14 (SRY-box transcription factor 14 [Source:HGNC Symbol;Acc:HGNC:11193])

HSP 1 Score: 145.206 bits (365), Expect = 1.995e-38
Identity = 64/77 (83.12%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Match: SOX1 (SRY-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11189])

HSP 1 Score: 142.895 bits (359), Expect = 4.244e-36
Identity = 62/75 (82.67%), Postives = 69/75 (92.00%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   50 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRR 124          
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Match: SOX21 (SRY-box transcription factor 21 [Source:HGNC Symbol;Acc:HGNC:11197])

HSP 1 Score: 139.428 bits (350), Expect = 4.403e-36
Identity = 62/77 (80.52%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSR QRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 VKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Match: SOX3 (SRY-box transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11199])

HSP 1 Score: 141.354 bits (355), Expect = 4.137e-35
Identity = 60/75 (80.00%), Postives = 70/75 (93.33%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            R++RPMNAFMVWSRGQRRKM++ENPKMHNSEISKRLG+ WK L++ +K+PFIDEAKRLRA H KE+PDYKYRPRR
Sbjct:  138 RVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRR 212          
BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 149.443 bits (376), Expect = 8.889e-40
Identity = 66/89 (74.16%), Postives = 77/89 (86.52%), Query Frame = 3
Query:  978 NANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            +  K   K + R++RPMNAFMVWSRGQR+KM++ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   48 STGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTK 136          
BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 149.443 bits (376), Expect = 8.889e-40
Identity = 66/89 (74.16%), Postives = 77/89 (86.52%), Query Frame = 3
Query:  978 NANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            +  K   K + R++RPMNAFMVWSRGQR+KM++ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   48 STGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTK 136          
BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 149.443 bits (376), Expect = 8.889e-40
Identity = 66/89 (74.16%), Postives = 77/89 (86.52%), Query Frame = 3
Query:  978 NANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            +  K   K + R++RPMNAFMVWSRGQR+KM++ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   48 STGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTK 136          
BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Match: sox-3 (SOX (Mammalian SRY box) family [Source:UniProtKB/TrEMBL;Acc:Q20201])

HSP 1 Score: 143.28 bits (360), Expect = 1.379e-38
Identity = 63/77 (81.82%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSRGQRRKM+ +NPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:   48 VKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKQLSEQEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 124          
BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Match: sox-4 (SOX (Mammalian SRY box) family [Source:UniProtKB/TrEMBL;Acc:Q17922])

HSP 1 Score: 103.219 bits (256), Expect = 1.734e-24
Identity = 42/82 (51.22%), Postives = 61/82 (74.39%), Query Frame = 3
Query: 1002 KEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI 1247
            +E RI+RPMNAFMVWS+ +R++++    K HNS+ISK LG+ W+ + E +K PF++ AK+LR  H   HPDY YRPRR+ ++
Sbjct:   81 REPRIKRPMNAFMVWSQQRRQQIAATGQKFHNSDISKMLGAEWRKMEEHEKVPFVERAKQLREEHFNAHPDYVYRPRRRKRV 162          
BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Match: SoxN (gene:FBgn0029123 transcript:FBtr0079733)

HSP 1 Score: 145.976 bits (367), Expect = 3.152e-36
Identity = 62/75 (82.67%), Postives = 69/75 (92.00%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            R++RPMNAFMVWSRGQRRKM+ +NPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:  178 RVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRR 252          
BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Match: Sox21a (gene:FBgn0036411 transcript:FBtr0075748)

HSP 1 Score: 141.739 bits (356), Expect = 4.869e-36
Identity = 63/77 (81.82%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ +NPKMHNSEISKRLG+ WK L+E  K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:  121 IKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 197          
BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Match: Sox21a (gene:FBgn0036411 transcript:FBtr0330178)

HSP 1 Score: 142.124 bits (357), Expect = 5.215e-36
Identity = 63/77 (81.82%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ +NPKMHNSEISKRLG+ WK L+E  K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:  121 IKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 197          
BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Match: SoxN (gene:FBgn0029123 transcript:FBtr0330210)

HSP 1 Score: 147.132 bits (370), Expect = 7.230e-36
Identity = 62/75 (82.67%), Postives = 69/75 (92.00%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            R++RPMNAFMVWSRGQRRKM+ +NPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:  178 RVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRR 252          
BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Match: D (gene:FBgn0000411 transcript:FBtr0333036)

HSP 1 Score: 139.428 bits (350), Expect = 2.565e-35
Identity = 61/81 (75.31%), Postives = 71/81 (87.65%), Query Frame = 3
Query: 1002 KEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            +E  I+RPMNAFMVWSR QRR+++ +NPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:  138 QEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 218          
BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 147.902 bits (372), Expect = 1.144e-38
Identity = 66/79 (83.54%), Postives = 72/79 (91.14%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI 1247
            RI+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K 
Sbjct:   37 RIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKT 115          
BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Match: sox14 (SRY-box transcription factor 14 [Source:NCBI gene;Acc:557661])

HSP 1 Score: 143.665 bits (361), Expect = 3.529e-38
Identity = 64/77 (83.12%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Match: sox1a (SRY-box transcription factor 1a [Source:NCBI gene;Acc:436756])

HSP 1 Score: 145.206 bits (365), Expect = 1.578e-37
Identity = 63/84 (75.00%), Postives = 72/84 (85.71%), Query Frame = 3
Query:  984 NKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            N  +   + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   27 NSGSKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRR 110          
BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Match: sox1a (SRY-box transcription factor 1a [Source:NCBI gene;Acc:436756])

HSP 1 Score: 145.206 bits (365), Expect = 1.578e-37
Identity = 63/84 (75.00%), Postives = 72/84 (85.71%), Query Frame = 3
Query:  984 NKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            N  +   + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   27 NSGSKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRR 110          
BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Match: sox1a (SRY-box transcription factor 1a [Source:NCBI gene;Acc:436756])

HSP 1 Score: 145.206 bits (365), Expect = 1.578e-37
Identity = 63/84 (75.00%), Postives = 72/84 (85.71%), Query Frame = 3
Query:  984 NKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            N  +   + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   27 NSGSKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRR 110          
BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Match: sox2 (SRY-box 2 [Source:NCBI gene;Acc:407873])

HSP 1 Score: 148.288 bits (373), Expect = 9.346e-39
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   36 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 113          
BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Match: spag16 (sperm associated antigen 16 [Source:Xenbase;Acc:XB-GENE-949128])

HSP 1 Score: 144.821 bits (364), Expect = 2.464e-38
Identity = 64/77 (83.12%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Match: gsr (glutathione reductase [Source:Xenbase;Acc:XB-GENE-997099])

HSP 1 Score: 140.584 bits (353), Expect = 1.865e-36
Identity = 68/112 (60.71%), Postives = 80/112 (71.43%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIAS 1349
            ++RPMNAFMVWSR QRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRRK K        T + +DK         +G H+   +A 
Sbjct:    8 VKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPK--------TLLKKDKFAFPMPYGFTGDHDGLKVAG 111          
BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Match: sox3 (SRY-box 3 [Source:NCBI gene;Acc:493228])

HSP 1 Score: 140.198 bits (352), Expect = 5.334e-36
Identity = 61/77 (79.22%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1005 EARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LS+ +K+PFIDEAKRLRA H KE+PDYKYRPRR
Sbjct:   37 QERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGADWKLLSDSEKRPFIDEAKRLRAVHMKEYPDYKYRPRR 113          
BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Match: sox17b.3 (SRY-box 17 alpha [Source:NCBI gene;Acc:395066])

HSP 1 Score: 122.865 bits (307), Expect = 2.276e-29
Identity = 48/83 (57.83%), Postives = 69/83 (83.13%), Query Frame = 3
Query:  999 KKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI 1247
            K EARIRRPMNAFMVW++ +R++++ +NP +HN+E+SK LG  WKSL+   K+PF++EA+RLR  H +++PDYKYRPRRK ++
Sbjct:   56 KAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKSLTLASKRPFVEEAERLRVQHIQDYPDYKYRPRRKKQV 138          
BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Match: Sox2 (SRY (sex determining region Y)-box 2 [Source:MGI Symbol;Acc:MGI:98364])

HSP 1 Score: 148.288 bits (373), Expect = 9.745e-39
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   42 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 119          
BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Match: Sox14 (SRY (sex determining region Y)-box 14 [Source:MGI Symbol;Acc:MGI:98362])

HSP 1 Score: 145.206 bits (365), Expect = 1.370e-38
Identity = 64/77 (83.12%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Match: Sox14 (SRY (sex determining region Y)-box 14 [Source:MGI Symbol;Acc:MGI:98362])

HSP 1 Score: 139.428 bits (350), Expect = 2.048e-37
Identity = 62/74 (83.78%), Postives = 67/74 (90.54%), Query Frame = 3
Query: 1023 PMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            PMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    2 PMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 75          
BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Match: Sox1 (SRY (sex determining region Y)-box 1 [Source:MGI Symbol;Acc:MGI:98357])

HSP 1 Score: 143.665 bits (361), Expect = 1.802e-36
Identity = 63/81 (77.78%), Postives = 71/81 (87.65%), Query Frame = 3
Query:  993 TDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            T   + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   44 TKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRR 124          
BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Match: Sox21 (SRY (sex determining region Y)-box 21 [Source:MGI Symbol;Acc:MGI:2654070])

HSP 1 Score: 139.813 bits (351), Expect = 2.854e-36
Identity = 62/77 (80.52%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSR QRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 VKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. UniProt
Match: sp|Q21305|SOX2_CAEEL (Transcription factor sox-2 OS=Caenorhabditis elegans OX=6239 GN=sox-2 PE=1 SV=2)

HSP 1 Score: 149.443 bits (376), Expect = 1.131e-38
Identity = 66/89 (74.16%), Postives = 77/89 (86.52%), Query Frame = 3
Query:  978 NANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            +  K   K + R++RPMNAFMVWSRGQR+KM++ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   48 STGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTK 136          
BLAST of Transcription factor Sox-2 vs. UniProt
Match: sp|P48430|SOX2_CHICK (Transcription factor SOX-2 OS=Gallus gallus OX=9031 GN=SOX2 PE=1 SV=1)

HSP 1 Score: 150.214 bits (378), Expect = 1.140e-38
Identity = 69/91 (75.82%), Postives = 78/91 (85.71%), Query Frame = 3
Query:  972 NQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            N  AN Q +  + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   26 NSAANNQKNSPD-RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 115          
BLAST of Transcription factor Sox-2 vs. UniProt
Match: sp|O42569|SOX2_XENLA (Transcription factor Sox-2 OS=Xenopus laevis OX=8355 GN=sox2 PE=1 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 4.675e-38
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   36 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 113          
BLAST of Transcription factor Sox-2 vs. UniProt
Match: sp|Q6NVN0|SOX2_XENTR (Transcription factor Sox-2 OS=Xenopus tropicalis OX=8364 GN=sox2 PE=2 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 4.951e-38
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   36 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 113          
BLAST of Transcription factor Sox-2 vs. UniProt
Match: sp|P48432|SOX2_MOUSE (Transcription factor SOX-2 OS=Mus musculus OX=10090 GN=Sox2 PE=1 SV=2)

HSP 1 Score: 147.902 bits (372), Expect = 8.017e-38
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   42 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 119          
BLAST of Transcription factor Sox-2 vs. TrEMBL
Match: gnl|BL_ORD_ID|20906436 (tr|A0A0A7M425|A0A0A7M425_SCHPL SOXB1-2 (Fragment) OS=Schmidtea polychroa OX=50054 GN=soxb1-2 PE=2 SV=1)

HSP 1 Score: 563.148 bits (1450), Expect = 0.000e+0
Identity = 271/291 (93.13%), Postives = 280/291 (96.22%), Query Frame = 3
Query:  588 FIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLXXXXXXXXXYSNYPVC 1460
            FIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDK IN+YYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCD++NNSSPE+KDNQSR+KTETQNSIQINQNA+KQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAAN+HPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYL  +  +      YPVC
Sbjct:    1 FIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKNINNYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDEINNSSPEMKDNQSRIKTETQNSIQINQNASKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANNHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLANKLVREQD-XQYPVC 290          
BLAST of Transcription factor Sox-2 vs. TrEMBL
Match: gnl|BL_ORD_ID|19608500 (tr|T2FHP9|T2FHP9_DUGJA SoxB OS=Dugesia japonica OX=6161 GN=soxB PE=2 SV=1)

HSP 1 Score: 540.421 bits (1391), Expect = 0.000e+0
Identity = 327/360 (90.83%), Postives = 339/360 (94.17%), Query Frame = 3
Query:  996 DKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPT--NMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLXXXXXXXXXYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLXXXXXXXXXXXXXXXXXXXXXSHCFTISPHILDGNFLAANAQNIMFHXXXXXXXXXXXXXXXNFNGVEMTPLYTXXXXXXXXXXXXXXXXXXXXTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI 2069
            DKKE RIRRPMNAFMVWSRGQRRK SVENPKMHNSEISKRLGSMWKSLSE+DKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAAN+HP    N+PQDKHGKKYVNP SGHHNNQN+ASTSL SDFHFQQLQQDS NIYL QQTGQG GYSNYPVCLDPNYGTMYYTPNGV+YPQGPLQPISTLGGLQASISQNSNSHG PASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPH++DG FLAANA NIMFHNSSSAFTFPSSNS+SN+NGV+MTPLY SSHNSPDSSSHPN NLNSISTTH+A+ELSNHL NRID FINQNMLADG Q NSN NNSISLQQQTIAFNNI
Sbjct:    2 DKKETRIRRPMNAFMVWSRGQRRKTSVENPKMHNSEISKRLGSMWKSLSELDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANNHPSVTANLPQDKHGKKYVNPASGHHNNQNVASTSLPSDFHFQQLQQDSTNIYLSQQTGQGAGYSNYPVCLDPNYGTMYYTPNGVLYPQGPLQPISTLGGLQASISQNSNSHGAPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPHLIDGGFLAANAPNIMFHNSSSAFTFPSSNSMSNYNGVDMTPLYASSHNSPDSSSHPNTNLNSISTTHVANELSNHLGNRIDLFINQNMLADGNQGNSNTNNSISLQQQTIAFNNI 361          
BLAST of Transcription factor Sox-2 vs. TrEMBL
Match: gnl|BL_ORD_ID|24045698 (tr|A0A1I7S6E7|A0A1I7S6E7_BURXY HMG box domain-containing protein OS=Bursaphelenchus xylophilus OX=6326 PE=4 SV=1)

HSP 1 Score: 157.918 bits (398), Expect = 3.269e-38
Identity = 73/113 (64.60%), Postives = 88/113 (77.88%), Query Frame = 3
Query:  918 IKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAAN 1256
            +K + + L+T+ Q+       A K+   +++R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG  WK LSE DK+PFIDEAKRLRA H K+HPDYKYRPRRKSK   N
Sbjct:   81 LKHSPNLLQTQLQDHQMGQSAAAKKQQLEDSRVKRPMNAFMVWSRGQRRKMATENPKMHNSEISKRLGQEWKELSEADKRPFIDEAKRLRAIHMKDHPDYKYRPRRKSKTQGN 193          
BLAST of Transcription factor Sox-2 vs. TrEMBL
Match: gnl|BL_ORD_ID|16256166 (tr|A0A183A526|A0A183A526_9TREM HMG box domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS2061 PE=4 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 9.690e-38
Identity = 68/89 (76.40%), Postives = 77/89 (86.52%), Query Frame = 3
Query:  999 KKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHP 1265
            KKE R++RPMNAFMVWSRGQRR+M+ ENPKMHNSEISKRLGSMWK L E +KKPFIDEAKRLRANH  ++PDYKYRPRRK K+    +P
Sbjct:   14 KKEDRVKRPMNAFMVWSRGQRRRMAQENPKMHNSEISKRLGSMWKGLCEAEKKPFIDEAKRLRANHMAQYPDYKYRPRRKHKVCEFINP 102          
BLAST of Transcription factor Sox-2 vs. TrEMBL
Match: gnl|BL_ORD_ID|20959502 (tr|A0A0K8RKI6|A0A0K8RKI6_IXORI Putative hmg-box transcription factor OS=Ixodes ricinus OX=34613 PE=2 SV=1)

HSP 1 Score: 153.68 bits (387), Expect = 9.804e-38
Identity = 67/78 (85.90%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI 1247
            I+RPMNAFMVWSRGQRRKM+VENPKMHNSEISKRLG+ WK LSE DK+PFIDEAKRLRA H KEHPDYKYRPRRK K+
Sbjct:   36 IKRPMNAFMVWSRGQRRKMAVENPKMHNSEISKRLGAEWKQLSETDKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKV 113          
BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 145.976 bits (367), Expect = 9.354e-39
Identity = 65/78 (83.33%), Postives = 72/78 (92.31%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K
Sbjct:   38 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTK 115          
BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Match: ENSAMXT00000026650.2 (transcription factor Sox-14-like [Source:NCBI gene;Acc:103039590])

HSP 1 Score: 142.51 bits (358), Expect = 5.146e-38
Identity = 62/77 (80.52%), Postives = 71/77 (92.21%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSRGQRR+M++ENPKMHNSEISKRLG+ WK LSE  K+P+IDEAKRLRA H KEHP+YKYRPRRKSK
Sbjct:    8 VKRPMNAFMVWSRGQRRRMAMENPKMHNSEISKRLGAEWKLLSEAQKRPYIDEAKRLRAQHMKEHPNYKYRPRRKSK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Match: ENSAMXT00000004288.2 (pep primary_assembly:Astyanax_mexicanus-2.0:13:15067225:15068019:-1 gene:ENSAMXG00000004192.2 transcript:ENSAMXT00000004288.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.895 bits (359), Expect = 5.697e-38
Identity = 63/77 (81.82%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Match: sox19a (transcription factor Sox-19a-like [Source:NCBI gene;Acc:103036028])

HSP 1 Score: 144.821 bits (364), Expect = 7.750e-38
Identity = 63/80 (78.75%), Postives = 73/80 (91.25%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIA 1250
            +++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK L++ +K+PFIDEAKRLRA H KEHPDYKY+PRRKSK A
Sbjct:   65 KVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTDAEKRPFIDEAKRLRALHMKEHPDYKYKPRRKSKPA 144          
BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Match: sox21b (SRY-box transcription factor 21b [Source:NCBI gene;Acc:406246])

HSP 1 Score: 141.739 bits (356), Expect = 1.132e-37
Identity = 62/77 (80.52%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSR QRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 VKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Match: sox1b (SRY-box transcription factor 1b [Source:NCBI gene;Acc:562710])

HSP 1 Score: 147.132 bits (370), Expect = 2.526e-38
Identity = 62/75 (82.67%), Postives = 69/75 (92.00%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK L+E +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   58 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRALHMKEHPDYKYRPRR 132          
BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Match: sox4b (SRY-box transcription factor 4b [Source:ZFIN;Acc:ZDB-GENE-040426-1274])

HSP 1 Score: 115.546 bits (288), Expect = 7.600e-28
Identity = 50/79 (63.29%), Postives = 64/79 (81.01%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIA 1250
            I+RPMNAFMVWS+ +RRK+  ++P MHN+EISKRLG  WK L E +K PFI EA+RLR  H  ++PDYKYRPR+K+K+A
Sbjct:   62 IKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGRRWKQLKESEKVPFIREAERLRLKHMADYPDYKYRPRKKAKLA 140          
BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Match: sox10 (SRY-box transcription factor 10 [Source:ZFIN;Acc:ZDB-GENE-011207-1])

HSP 1 Score: 112.079 bits (279), Expect = 3.293e-27
Identity = 43/77 (55.84%), Postives = 66/77 (85.71%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVW++  RRK+S + P++HN+E+SK LG +W+ L+E +K+PF++EA+RLR  H+K+HPDYKY+PRR+ +
Sbjct:  112 VKRPMNAFMVWAQAARRKLSDQYPQLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRMQHKKDHPDYKYQPRRRKQ 188          
BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Match: sox12 (SRY-box transcription factor 12 [Source:ZFIN;Acc:ZDB-GENE-040724-33])

HSP 1 Score: 112.464 bits (280), Expect = 1.006e-26
Identity = 47/77 (61.04%), Postives = 63/77 (81.82%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWS+ +RRK+ +E+P +HN+EISKRLG  WK L + +K PF+ EA+RLR  H  ++PDYKYRPR+K+K
Sbjct:   60 IKRPMNAFMVWSQIERRKIMMESPDVHNAEISKRLGRRWKQLKDCEKVPFMREAERLRLKHMADYPDYKYRPRKKAK 136          
BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010223.1 (pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 gene:ENSPMAG00000009255.1 transcript:ENSPMAT00000010223.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 101.679 bits (252), Expect = 4.704e-26
Identity = 44/80 (55.00%), Postives = 63/80 (78.75%), Query Frame = 3
Query: 1005 EARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            E RI RPMNAFMVW++ +RR+++ +NP +HN+E+SK LG  W++L+   ++P ++EA+RLR  H  EHPDYKYRPRRK +
Sbjct:    3 EPRIPRPMNAFMVWAKDERRRLAKQNPDLHNAELSKMLGKSWRALTPESRRPCVEEAERLRLLHLSEHPDYKYRPRRKKQ 82          
BLAST of Transcription factor Sox-2 vs. Ensembl Yeast
Match: ROX1 (Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance [Source:SGD;Acc:S000006269])

HSP 1 Score: 55.4546 bits (132), Expect = 1.921e-8
Identity = 30/82 (36.59%), Postives = 49/82 (59.76%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKM-------SVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            +I RP NAF+++ +   R +        VE P  HNS ISK +G+ WK L   DK  + + A++ +  H++++P+YKY+P R
Sbjct:    9 KIPRPKNAFILFRQHYHRILIDEWTAQGVEIP--HNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYKPVR 88          
BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Match: EDO40934 (Predicted protein; Sox family protein B1 [Source:UniProtKB/TrEMBL;Acc:Q3S381])

HSP 1 Score: 144.05 bits (362), Expect = 1.322e-37
Identity = 70/104 (67.31%), Postives = 82/104 (78.85%), Query Frame = 3
Query:  939 LKTETQNSIQIN-QNANKQTDKKEA-RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            + T + N I  N  N N+ T    A R++RPMNAFMVWSR +RRKM+ +NPKMHNSEISKRLGS WK LSE +K+P+IDEA+RLRA H KEHPDYKYRPRRKSK
Sbjct:    6 ILTPSPNPISGNGTNGNESTKANSADRVKRPMNAFMVWSRERRRKMAQDNPKMHNSEISKRLGSEWKLLSEQEKRPYIDEARRLRAVHMKEHPDYKYRPRRKSK 109          
BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Match: EDO32666 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUF3])

HSP 1 Score: 135.576 bits (340), Expect = 9.227e-36
Identity = 59/77 (76.62%), Postives = 69/77 (89.61%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            ++RPMNAFMVWSR +RRK++ ENPKMHNSEISKRLGS WK L++ DKKPF++EAK+LRA H KEHPDYKYRPRRK K
Sbjct:   10 VKRPMNAFMVWSREERRKIAQENPKMHNSEISKRLGSEWKQLADDDKKPFVEEAKKLRAQHMKEHPDYKYRPRRKPK 86          
BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Match: EDO37974 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEA1])

HSP 1 Score: 115.161 bits (287), Expect = 2.266e-27
Identity = 45/75 (60.00%), Postives = 64/75 (85.33%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRK 1238
            ++RPMNAFMVW++  RRK++ + P +HN+E+SK LG +WK L++ +KKPFI+EA+RLR  H++EHPDYKY+PRRK
Sbjct:   64 VKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWKLLNDSEKKPFIEEAERLRIKHKREHPDYKYQPRRK 138          
BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Match: EDO47688 (Predicted protein; Sox family protein 2 [Source:UniProtKB/TrEMBL;Acc:Q3S383])

HSP 1 Score: 110.538 bits (275), Expect = 3.316e-27
Identity = 48/81 (59.26%), Postives = 66/81 (81.48%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAAN 1256
            I+RPMNA+MVWSR +RR+++ E P+M NSEISKRLG  W SL+  +K+P+++EAKRLR  H+K+HPDYKY+P+RK K +  
Sbjct:    8 IKRPMNAYMVWSRKERRRIAEECPRMLNSEISKRLGLEWNSLTLDEKQPYVEEAKRLRELHKKDHPDYKYQPKRKPKTSPK 88          
BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Match: EDO44142 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWK8])

HSP 1 Score: 112.849 bits (281), Expect = 6.724e-27
Identity = 48/94 (51.06%), Postives = 72/94 (76.60%), Query Frame = 3
Query:  981 ANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRK--SKIAAN 1256
            A  + D +  RI+RPMNAFMVW++ +RR+++  NP++HN+E+SK LG  W++L+   K+PF+DEA+RLR  H +++P+YKYRPRR+  SK AA 
Sbjct:   62 ARTEKDDETERIKRPMNAFMVWAQVERRRLADANPELHNAELSKMLGLTWRALNSTQKRPFVDEAERLRLQHMQDYPNYKYRPRRRKHSKRAAK 155          
BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 145.591 bits (366), Expect = 8.376e-39
Identity = 65/79 (82.28%), Postives = 72/79 (91.14%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI 1247
            R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+PFIDEAKRLRA H KEHPDYKYRPRRK+K 
Sbjct:   39 RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKT 117          
BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Match: ENSORLT00000029054.1 (transcription factor Sox-14-like [Source:NCBI gene;Acc:111949029])

HSP 1 Score: 144.05 bits (362), Expect = 1.822e-38
Identity = 63/77 (81.82%), Postives = 71/77 (92.21%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK+LS+ DK+PFIDEAKRLRA H +EHPDYKYRPRRK +
Sbjct:    8 IKRPMNAFMVWSRGQRRKMARENPKMHNSEISKRLGAEWKTLSDSDKRPFIDEAKRLRAQHLREHPDYKYRPRRKPR 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Match: sox14 (SRY-box transcription factor 14 [Source:NCBI gene;Acc:100304454])

HSP 1 Score: 144.05 bits (362), Expect = 2.700e-38
Identity = 64/77 (83.12%), Postives = 70/77 (90.91%), Query Frame = 3
Query: 1014 IRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            I+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK LSE +K+P+IDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:    8 IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPK 84          
BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Match: sox1 (SRY-box 1 [Source:NCBI gene;Acc:100304447])

HSP 1 Score: 145.591 bits (366), Expect = 5.778e-38
Identity = 63/84 (75.00%), Postives = 72/84 (85.71%), Query Frame = 3
Query:  984 NKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            N  +   + R++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK +SE +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   27 NGGSKANQERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRR 110          
BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Match: ENSORLT00000037481.1 (transcription factor Sox-1a-like [Source:NCBI gene;Acc:111949309])

HSP 1 Score: 145.591 bits (366), Expect = 8.898e-38
Identity = 62/75 (82.67%), Postives = 69/75 (92.00%), Query Frame = 3
Query: 1011 RIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRR 1235
            RI+RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK ++E +K+PFIDEAKRLRA H KEHPDYKYRPRR
Sbjct:   34 RIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMTEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRR 108          
BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Match: SMESG000067682.1 (SMESG000067682.1)

HSP 1 Score: 1008.44 bits (2606), Expect = 0.000e+0
Identity = 574/574 (100.00%), Postives = 574/574 (100.00%), Query Frame = 3
Query:  348 MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLXXXXXXXXXYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLXXXXXXXXXXXXXXXXXXXXXSHCFTISPHILDGNFLAANAQNIMFHXXXXXXXXXXXXXXXNFNGVEMTPLYTXXXXXXXXXXXXXXXXXXXXTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI 2069
            MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLGQQTGQGTGYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPHILDGNFLAANAQNIMFHNSSSAFTFPSSNSLSNFNGVEMTPLYTSSHNSPDSSSHPNPNLNSISTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI
Sbjct:    1 MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLGQQTGQGTGYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPHILDGNFLAANAQNIMFHNSSSAFTFPSSNSLSNFNGVEMTPLYTSSHNSPDSSSHPNPNLNSISTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI 574          
BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Match: SMESG000060099.1 (SMESG000060099.1)

HSP 1 Score: 1008.44 bits (2606), Expect = 0.000e+0
Identity = 574/574 (100.00%), Postives = 574/574 (100.00%), Query Frame = 3
Query:  348 MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLXXXXXXXXXYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLXXXXXXXXXXXXXXXXXXXXXSHCFTISPHILDGNFLAANAQNIMFHXXXXXXXXXXXXXXXNFNGVEMTPLYTXXXXXXXXXXXXXXXXXXXXTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI 2069
            MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLGQQTGQGTGYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPHILDGNFLAANAQNIMFHNSSSAFTFPSSNSLSNFNGVEMTPLYTSSHNSPDSSSHPNPNLNSISTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI
Sbjct:    1 MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSNQNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQNYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLTNLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKIAANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDSANIYLGQQTGQGTGYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLGGLQASISQNSNSHGGPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQNSHCFTISPHILDGNFLAANAQNIMFHNSSSAFTFPSSNSLSNFNGVEMTPLYTSSHNSPDSSSHPNPNLNSISTTHIASELSNHLSNRIDQFINQNMLADGTQNNSNANNSISLQQQTIAFNNI 574          
BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Match: SMESG000011244.1 (SMESG000011244.1)

HSP 1 Score: 155.992 bits (393), Expect = 9.524e-40
Identity = 70/98 (71.43%), Postives = 80/98 (81.63%), Query Frame = 3
Query:  951 TQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            T NS     N    + KK+ R++RPMNAFMVWSRGQRR+M+ +NPKMHNSEISKRLG MWK+LSE DKKPFIDEAKRLRANH  ++PDYKYRPRRK K
Sbjct:  236 TANSQTSQSNITSSSQKKDDRVKRPMNAFMVWSRGQRRRMAQDNPKMHNSEISKRLGGMWKNLSEEDKKPFIDEAKRLRANHMTQYPDYKYRPRRKHK 333          
BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Match: SMESG000011244.1 (SMESG000011244.1)

HSP 1 Score: 155.992 bits (393), Expect = 9.923e-40
Identity = 70/98 (71.43%), Postives = 80/98 (81.63%), Query Frame = 3
Query:  951 TQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            T NS     N    + KK+ R++RPMNAFMVWSRGQRR+M+ +NPKMHNSEISKRLG MWK+LSE DKKPFIDEAKRLRANH  ++PDYKYRPRRK K
Sbjct:  235 TANSQTSQSNITSSSQKKDDRVKRPMNAFMVWSRGQRRRMAQDNPKMHNSEISKRLGGMWKNLSEEDKKPFIDEAKRLRANHMTQYPDYKYRPRRKHK 332          
BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Match: SMESG000077970.1 (SMESG000077970.1)

HSP 1 Score: 145.206 bits (365), Expect = 1.242e-37
Identity = 73/115 (63.48%), Postives = 91/115 (79.13%), Query Frame = 3
Query:  909 SPEI---KDNQSRLKTETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 1244
            SPEI    +++S +  ET+   +IN +++  +  KE  ++RPMNAFMVWSRGQRRKM+ ENPKMHNSEISKRLG+ WK L+E+ K+PFIDEAKRLRA H K+HPDYKYRPRRK K
Sbjct:   35 SPEIGYSDEDKSDIVEETE---KINVSSSNAS-IKEDHVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKHLTELQKRPFIDEAKRLRAIHMKDHPDYKYRPRRKPK 145          
The following BLAST results are available for this feature:
BLAST of Transcription factor Sox-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SOX21.818e-3883.33SRY-box transcription factor 2 [Source:HGNC Symbol... [more]
SOX141.995e-3883.12SRY-box transcription factor 14 [Source:HGNC Symbo... [more]
SOX14.244e-3682.67SRY-box transcription factor 1 [Source:HGNC Symbol... [more]
SOX214.403e-3680.52SRY-box transcription factor 21 [Source:HGNC Symbo... [more]
SOX34.137e-3580.00SRY-box transcription factor 3 [Source:HGNC Symbol... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox-28.889e-4074.16Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-28.889e-4074.16Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-28.889e-4074.16Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-31.379e-3881.82SOX (Mammalian SRY box) family [Source:UniProtKB/... [more]
sox-41.734e-2451.22SOX (Mammalian SRY box) family [Source:UniProtKB/... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SoxN3.152e-3682.67gene:FBgn0029123 transcript:FBtr0079733[more]
Sox21a4.869e-3681.82gene:FBgn0036411 transcript:FBtr0075748[more]
Sox21a5.215e-3681.82gene:FBgn0036411 transcript:FBtr0330178[more]
SoxN7.230e-3682.67gene:FBgn0029123 transcript:FBtr0330210[more]
D2.565e-3575.31gene:FBgn0000411 transcript:FBtr0333036[more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox21.144e-3883.54SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
sox143.529e-3883.12SRY-box transcription factor 14 [Source:NCBI gene;... [more]
sox1a1.578e-3775.00SRY-box transcription factor 1a [Source:NCBI gene;... [more]
sox1a1.578e-3775.00SRY-box transcription factor 1a [Source:NCBI gene;... [more]
sox1a1.578e-3775.00SRY-box transcription factor 1a [Source:NCBI gene;... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox29.346e-3983.33SRY-box 2 [Source:NCBI gene;Acc:407873][more]
spag162.464e-3883.12sperm associated antigen 16 [Source:Xenbase;Acc:XB... [more]
gsr1.865e-3660.71glutathione reductase [Source:Xenbase;Acc:XB-GENE-... [more]
sox35.334e-3679.22SRY-box 3 [Source:NCBI gene;Acc:493228][more]
sox17b.32.276e-2957.83SRY-box 17 alpha [Source:NCBI gene;Acc:395066][more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sox29.745e-3983.33SRY (sex determining region Y)-box 2 [Source:MGI S... [more]
Sox141.370e-3883.12SRY (sex determining region Y)-box 14 [Source:MGI ... [more]
Sox142.048e-3783.78SRY (sex determining region Y)-box 14 [Source:MGI ... [more]
Sox11.802e-3677.78SRY (sex determining region Y)-box 1 [Source:MGI S... [more]
Sox212.854e-3680.52SRY (sex determining region Y)-box 21 [Source:MGI ... [more]
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BLAST of Transcription factor Sox-2 vs. UniProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q21305|SOX2_CAEEL1.131e-3874.16Transcription factor sox-2 OS=Caenorhabditis elega... [more]
sp|P48430|SOX2_CHICK1.140e-3875.82Transcription factor SOX-2 OS=Gallus gallus OX=903... [more]
sp|O42569|SOX2_XENLA4.675e-3883.33Transcription factor Sox-2 OS=Xenopus laevis OX=83... [more]
sp|Q6NVN0|SOX2_XENTR4.951e-3883.33Transcription factor Sox-2 OS=Xenopus tropicalis O... [more]
sp|P48432|SOX2_MOUSE8.017e-3883.33Transcription factor SOX-2 OS=Mus musculus OX=1009... [more]
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BLAST of Transcription factor Sox-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
gnl|BL_ORD_ID|209064360.000e+093.13tr|A0A0A7M425|A0A0A7M425_SCHPL SOXB1-2 (Fragment) ... [more]
gnl|BL_ORD_ID|196085000.000e+090.83tr|T2FHP9|T2FHP9_DUGJA SoxB OS=Dugesia japonica OX... [more]
gnl|BL_ORD_ID|240456983.269e-3864.60tr|A0A1I7S6E7|A0A1I7S6E7_BURXY HMG box domain-cont... [more]
gnl|BL_ORD_ID|162561669.690e-3876.40tr|A0A183A526|A0A183A526_9TREM HMG box domain-cont... [more]
gnl|BL_ORD_ID|209595029.804e-3885.90tr|A0A0K8RKI6|A0A0K8RKI6_IXORI Putative hmg-box tr... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox29.354e-3983.33SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
ENSAMXT00000026650.25.146e-3880.52transcription factor Sox-14-like [Source:NCBI gene... [more]
ENSAMXT00000004288.25.697e-3881.82pep primary_assembly:Astyanax_mexicanus-2.0:13:150... [more]
sox19a7.750e-3878.75transcription factor Sox-19a-like [Source:NCBI gen... [more]
sox21b1.132e-3780.52SRY-box transcription factor 21b [Source:NCBI gene... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox1b2.526e-3882.67SRY-box transcription factor 1b [Source:NCBI gene;... [more]
sox4b7.600e-2863.29SRY-box transcription factor 4b [Source:ZFIN;Acc:Z... [more]
sox103.293e-2755.84SRY-box transcription factor 10 [Source:ZFIN;Acc:Z... [more]
sox121.006e-2661.04SRY-box transcription factor 12 [Source:ZFIN;Acc:Z... [more]
ENSPMAT00000010223.14.704e-2655.00pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 ge... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ROX11.921e-836.59Heme-dependent repressor of hypoxic genes; mediate... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO409341.322e-3767.31Predicted protein; Sox family protein B1 [Source:... [more]
EDO326669.227e-3676.62Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO379742.266e-2760.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476883.316e-2759.26Predicted protein; Sox family protein 2 [Source:U... [more]
EDO441426.724e-2751.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Transcription factor Sox-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox28.376e-3982.28SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
ENSORLT00000029054.11.822e-3881.82transcription factor Sox-14-like [Source:NCBI gene... [more]
sox142.700e-3883.12SRY-box transcription factor 14 [Source:NCBI gene;... [more]
sox15.778e-3875.00SRY-box 1 [Source:NCBI gene;Acc:100304447][more]
ENSORLT00000037481.18.898e-3882.67transcription factor Sox-1a-like [Source:NCBI gene... [more]
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BLAST of Transcription factor Sox-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000067682.10.000e+0100.00SMESG000067682.1[more]
SMESG000060099.10.000e+0100.00SMESG000060099.1[more]
SMESG000011244.19.524e-4071.43SMESG000011244.1[more]
SMESG000011244.19.923e-4071.43SMESG000011244.1[more]
SMESG000077970.11.242e-3763.48SMESG000077970.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001191 ID=SMED30001191|Name=Transcription factor Sox-2|organism=Schmidtea mediterranea sexual|type=transcript|length=2941bp
GTTCGTTTTCAAAGCAGCATAAATTTGCAACATCAGCTCTTCGTAGTAAC
TCAAGTATTACATTTGCGCTATTATCAATTCTACAATATCAAGAATCCAT
ATCGGAGAGAGAAACGAAACAAGAACCAGTAGTCATTGTTCCAGCATTCT
ATTAATATTATCAACTATTACTGGGATAAATCAATTGAATTCCTCATCTA
ACAATAAGTATTTGAAAAAAAGAAACAACAACCGCAAACAATACCGCAAC
GATTCAGACCCCAGTGTTACCAATAGAATAGAAATTGGAAATCTACAAAA
AAGTTTTTTTGTTTTCACTCTATATTGTGTTTTGCCGTAAAATCTACATG
TCGTTGCAACCACAATTTCGAGGCCAGTTGCCGATGATCTACGATACCTC
ATTAGACGGGGTGGAGAATCTCCGAGATGAAAGTCTACGAATGCCAAGTG
TCGGTGAATTCTATCAATCAACAAATCAATCACCAGTGGATTCGAATCAG
AATGAACTCAATGTTTTTCGGTCGTCAACAAATCACGGAGCCGACTATTC
GAGATCAAATCATTCTGATTCAACAATTGAGCATCCATTTATTATGGAAA
ACTCACTCGGCTATCGGCTGTCGATGCACCAGAGTGATTCGAATCAGAAT
TATTACAACGGTTGCATGCTAAGTGGATTACTACAAAACCGAGACAATGA
AGAAATGATCAGACATTTGCAACGTCAACAAAACATGGATAAAGGCATCA
ATAGCTACTACCATAATGATAGTGATGGGGGGTTGACGAATTTGACGAAT
TTAAAACGACCAACTTCGAATTATGTGAGCGAAGAAGACTATCTTAGCAG
CTCGTTGACACAGGATATAAAACAAGAAAGCTACCATTGTGATGACATGA
ACAATTCGAGTCCAGAAATAAAAGACAATCAAAGTCGACTAAAAACCGAA
ACCCAAAACTCCATTCAAATCAATCAAAATGCTAACAAACAAACCGATAA
GAAAGAAGCGAGAATTCGGCGGCCAATGAATGCTTTTATGGTTTGGTCTC
GAGGACAACGCCGCAAAATGTCAGTTGAGAATCCAAAAATGCACAATTCA
GAAATCAGCAAACGTTTGGGTTCGATGTGGAAATCTTTGAGCGAAATAGA
TAAGAAACCATTTATTGATGAGGCGAAACGTTTGAGAGCCAACCATCAGA
AAGAGCACCCAGATTACAAATATCGCCCGAGACGTAAGTCAAAAATCGCT
GCCAACAGCCATCCACCAACCAATATGCCTCAAGATAAACACGGGAAAAA
ATACGTAAATCCAACAAGTGGTCATCACAATAATCAAAATATTGCTTCAA
CATCATTATCTTCAGATTTCCATTTCCAACAACTTCAACAAGATTCGGCC
AATATTTATCTTGGCCAACAAACTGGTCAAGGAACAGGTTATTCCAATTA
TCCAGTATGCTTAGATCCGAATTACGGAACTATGTACTACACTCCAAATG
GAGTAATCTATCCGCAAGGTCCATTGCAACCAATCTCAACGCTAGGTGGT
TTGCAAGCTTCTATTTCTCAAAATTCAAATTCTCACGGCGGTCCAGCTAG
TAATCCAACCAGTTCCAATCATTCCAGTCCATTGACTTATAACACAACGA
CACCTGTCGGTGGAAACAACAATAACAATATTCTCAATTATCAAAATTCC
CATTGTTTTACAATTTCACCCCACATTCTTGATGGTAACTTTCTTGCAGC
CAATGCCCAGAATATAATGTTTCACAATTCATCGTCGGCATTCACATTTC
CATCGTCGAATTCGCTGTCAAACTTCAATGGAGTAGAAATGACTCCTCTT
TACACATCATCCCACAATTCTCCCGATTCTAGCAGCCATCCGAATCCGAA
TTTGAATTCCATATCCACAACTCACATAGCGAGTGAGCTATCCAATCATC
TTAGTAACCGAATAGACCAATTTATCAATCAGAACATGCTCGCTGACGGA
ACCCAAAACAATTCCAACGCAAACAACTCAATCTCATTACAACAACAAAC
AATCGCTTTCAACAACATCTAACGTGAAATCATTCCAAAATTTCCGATTG
AGATCTCGAATCACACCAAAACTTTTCAGATTTAAATCTAACCCGAGCTT
TTATTTTACAACATGCAACAAATGTATTTCAACATCTTTATTTCTATGAC
TATTACTAATTCTTTTTTTTACTTGTGAGTCTCTGAGCAAGATTACTATC
AATCCGTCAAAATTTCGAAACAATTAAAATAGAATACCTTAAAATTACCT
CATTTCGATGACGTCACAGTTGGTTTTTCTCGAGTTTTTTTTTGTTGAAA
AAAAATGTTACTTTAATCACTGACCGTGAAAACAACAACAATAAATCGAT
TTGAATATTTATTTATTTTTTTTTGTGGAAAAAATATCTTTTCACAGCAT
CAGTATTGTTTGATGAATTCACCGAGCCGTCTCCATTCAATACTTGCAGA
TTTCGACTATTGGAGAGATCGGTGGTCAGCGGCAAATTATCCAGAGAAAA
CTCCACACCAAGTTGAGCTGTCATTAATCATGTCCAAATTGTAAATAAAT
CTCATTTTTAAAGACTGTAAATTATTTTTTAAAAATAACTACCCCCAAAA
CAATAACAACAACAACAACAATTATTTTTTATTATTATTGTATCGTTTTG
ATTTTTATCATGAACATGTTTATTGGCAACACCATTGGCCTTTATGTAAG
TAGTAGATTAGGAATCTAAATTGGTGTCTGTTTGTTTTGTTTTATTATCT
GTCGAATTGCAAAGGATTTCGCTGCATGAAATTTCTTTCCAAAATAAAAA
AAACCACAAAATTTATTAATTCCAAAAAGAAATGCAAAATTAAATTATTT
TTGTGGCGAACTTTGTAATTTTGTTCTTCAGAATCGCTTAT
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protein sequence of SMED30001191-orf-1

>SMED30001191-orf-1 ID=SMED30001191-orf-1|Name=SMED30001191-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=575bp
MSLQPQFRGQLPMIYDTSLDGVENLRDESLRMPSVGEFYQSTNQSPVDSN
QNELNVFRSSTNHGADYSRSNHSDSTIEHPFIMENSLGYRLSMHQSDSNQ
NYYNGCMLSGLLQNRDNEEMIRHLQRQQNMDKGINSYYHNDSDGGLTNLT
NLKRPTSNYVSEEDYLSSSLTQDIKQESYHCDDMNNSSPEIKDNQSRLKT
ETQNSIQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHN
SEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSKI
AANSHPPTNMPQDKHGKKYVNPTSGHHNNQNIASTSLSSDFHFQQLQQDS
ANIYLGQQTGQGTGYSNYPVCLDPNYGTMYYTPNGVIYPQGPLQPISTLG
GLQASISQNSNSHGGPASNPTSSNHSSPLTYNTTTPVGGNNNNNILNYQN
SHCFTISPHILDGNFLAANAQNIMFHNSSSAFTFPSSNSLSNFNGVEMTP
LYTSSHNSPDSSSHPNPNLNSISTTHIASELSNHLSNRIDQFINQNMLAD
GTQNNSNANNSISLQQQTIAFNNI*
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Aliases
The feature 'Transcription factor Sox-2' has the following synonyms
Synonym
Spol-SoxB1-2
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000018Category 4 cell
PLANA:0000034epidermis
PLANA:0000054dorsal region of the epidermis
PLANA:0000096ventral epidermis
PLANA:0000099neuron
PLANA:0000141dorsal region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036910HMG_box_dom_sf
IPR009071HMG_box_dom
Vocabulary: biological process
TermDefinition
GO:0021982pineal gland development
GO:0030154cell differentiation
GO:0031099regeneration
GO:0031101fin regeneration
GO:0045893positive regulation of transcription, DNA-templated
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0048592eye morphogenesis
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060119inner ear receptor cell development
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0007275multicellular organism development
GO:0007399nervous system development
GO:0008283cell proliferation
GO:0021538epithalamus development
Vocabulary: molecular function
TermDefinition
GO:0043565sequence-specific DNA binding
GO:0003677DNA binding
GO:0003682chromatin binding
GO:0003700transcription factor activity, sequence-specific DNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009071High mobility group box domainSMARTSM00398hmgende2coord: 222..292
e-value: 1.6E-25
score: 100.8
IPR009071High mobility group box domainPFAMPF00505HMG_boxcoord: 224..291
e-value: 1.9E-25
score: 89.0
IPR009071High mobility group box domainPROSITEPS50118HMG_BOX_2coord: 223..291
score: 22.466
IPR036910High mobility group box domain superfamilyGENE3DG3DSA:1.10.30.10coord: 220..298
e-value: 7.5E-30
score: 105.3
IPR036910High mobility group box domain superfamilySUPERFAMILYSSF47095HMG-boxcoord: 222..301
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 284..314
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 408..428
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 181..203
NoneNo IPR availablePANTHERPTHR10270SOX TRANSCRIPTION FACTORcoord: 192..539
NoneNo IPR availablePANTHERPTHR10270:SF161SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATEDcoord: 192..539
NoneNo IPR availableCDDcd01388SOX-TCF_HMG-boxcoord: 222..293
e-value: 7.84385E-37
score: 129.34