Adenylate cyclase type
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Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30001170 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Adenylate cyclase type vs. Ensembl Human
Match: ADCY6 (adenylate cyclase 6 [Source:HGNC Symbol;Acc:HGNC:237]) HSP 1 Score: 323.553 bits (828), Expect = 8.201e-93 Identity = 269/886 (30.36%), Postives = 411/886 (46.39%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG----------------------------EKLMVTK---ERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHL-QSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDA-IACQVCSTFVIISAFFLIIESGGISKTTTL--VYMSGIPLIMIAGWICLVYK--SEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTI-SYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFL---------VDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS-KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
+ L ++LF + G+ + ++ AF + QA++ + + Q + +++P V E E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + VNMRVG+HSGRV ++G +++FDV+SNDV++AN +E+ G+ G++HI++ T + + Y G EK M+ K R +EG P VP D F+R +SK++ Q+GID S+ + + + + + E+ L ++ R++ + + LTF+ ++E + S KV F A +AC + F I L+I +T + +Y S L++I IC VY S P + R I ++GI+ LLV T A Y +G L+ A S+ I S L + L LL P D Y+ V L +D LKY L L LY ++ E R+ F +A +E + + L+NI+PK V A ++++ + Y ++ V+FASI NF Y E G L++L+ II FD ++ ++ LEKIKT+ YM ASGLNAS+ H+ L ++ L+ Q+ + NE + +F +KIG N GPV AG+IG KP YDIWG+TVNV+SRM ST +IQV+ +++ LA + E RG V +KGKG++ TY
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVP-------------DRAFSR--TKDSKAFR------------QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKY--------------SRKVDPRFGAYVACALL-VFCFICFIQLLI----FPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIF----SVLLVFTSAIANM------YFIGNMLLSLLA--SSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL--ARERRNDELYY-QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSF---NNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTY 1107
BLAST of Adenylate cyclase type vs. Ensembl Human
Match: ADCY6 (adenylate cyclase 6 [Source:HGNC Symbol;Acc:HGNC:237]) HSP 1 Score: 323.553 bits (828), Expect = 8.201e-93 Identity = 269/886 (30.36%), Postives = 411/886 (46.39%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG----------------------------EKLMVTK---ERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHL-QSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDA-IACQVCSTFVIISAFFLIIESGGISKTTTL--VYMSGIPLIMIAGWICLVYK--SEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTI-SYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFL---------VDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS-KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
+ L ++LF + G+ + ++ AF + QA++ + + Q + +++P V E E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + VNMRVG+HSGRV ++G +++FDV+SNDV++AN +E+ G+ G++HI++ T + + Y G EK M+ K R +EG P VP D F+R +SK++ Q+GID S+ + + + + + E+ L ++ R++ + + LTF+ ++E + S KV F A +AC + F I L+I +T + +Y S L++I IC VY S P + R I ++GI+ LLV T A Y +G L+ A S+ I S L + L LL P D Y+ V L +D LKY L L LY ++ E R+ F +A +E + + L+NI+PK V A ++++ + Y ++ V+FASI NF Y E G L++L+ II FD ++ ++ LEKIKT+ YM ASGLNAS+ H+ L ++ L+ Q+ + NE + +F +KIG N GPV AG+IG KP YDIWG+TVNV+SRM ST +IQV+ +++ LA + E RG V +KGKG++ TY
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVP-------------DRAFSR--TKDSKAFR------------QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKY--------------SRKVDPRFGAYVACALL-VFCFICFIQLLI----FPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIF----SVLLVFTSAIANM------YFIGNMLLSLLA--SSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL--ARERRNDELYY-QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSF---NNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTY 1107
BLAST of Adenylate cyclase type vs. Ensembl Human
Match: ADCY8 (adenylate cyclase 8 [Source:HGNC Symbol;Acc:HGNC:239]) HSP 1 Score: 317.005 bits (811), Expect = 6.477e-90 Identity = 266/886 (30.02%), Postives = 427/886 (48.19%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIY-EYS----SCVDFL----VDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q +LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S+ + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ V+ I LI+ + TT +PLI+ WI Y + IF I + F + + + +P L + +++ ++ + YF T A+++ +F SVLK A +Y LL T ++ Y S DFL V + + L F+ Q + L FL R K EI +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 321 VVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINFLGAILNILWCDFDKSIP--LKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA--IYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKE-----------EI--NEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1171 HSP 2 Score: 64.6994 bits (156), Expect = 9.927e-10 Identity = 64/277 (23.10%), Postives = 125/277 (45.13%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R+DH + + ++ + Y KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ K ++ETYL +P ++ +
Sbjct: 337 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RQDHAHCCVEMGLSMIKTIRYVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEDSLL 595
BLAST of Adenylate cyclase type vs. Ensembl Human
Match: ADCY9 (adenylate cyclase 9 [Source:HGNC Symbol;Acc:HGNC:240]) HSP 1 Score: 227.254 bits (578), Expect = 5.895e-60 Identity = 136/372 (36.56%), Postives = 206/372 (55.38%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQ--AKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-------------------------SIRSKDL-FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
FS+ + V+ ++YT+ HL +++ L + Y ++F + G + +E F S H E L+ + +L ++ G++L + + +R +S FLK+ Q+ ++++ A+K ++ I ++MP + + ++ SI+ + F +Q + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR+DHA CC+EMGLGM K I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+ T K + Y +G+ + + G A L + TY +
Sbjct: 224 FSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFET-----FGYHFRDE---ACFPSPGAGALHWE---------LLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERM--IHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVI-----ERLGQSVVADQLKGLKTYLI 571 HSP 2 Score: 186.037 bits (471), Expect = 5.371e-47 Identity = 166/567 (29.28%), Postives = 276/567 (48.68%), Query Frame = 2
Query: 1628 IGIDKSAL-EFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAF-------FLIIESGGISKTTTLVYMSGIPLIM----IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLL---LQP-----TKEMDIY-----EYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLN---ASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKH 3241
+ +D+SAL + ++ + K D + ++ D F PP+N +L F D E+E ++ +++ I + V F + F+ + F FL E+ + + + L++ +A I +V+ E +++ + L R IG + LP L V++ +E N + V + A++ C F S ++ AG L LL L P T +D E + C + + + F + LL++FL RE E + R+ ++ EA++ + + R A+ L NIIP +V Q+ S +Y+K + GV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN A ++ ++HL L F+ +++ + +N + N F L++G+N GP+TAG+IGT+K LYDIWGDTVN+ASRM +T +IQVS+ ++ L+ + F+YRG V +KGKG ++TYL + + +I +H
Sbjct: 705 VSLDQSALLPLRFKNIREKTDAHFVDVIKED-SLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEV----IKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSE-YETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQ--------TYSKNHDSGGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFN--FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQH 1254 HSP 3 Score: 64.6994 bits (156), Expect = 9.706e-10 Identity = 62/262 (23.66%), Postives = 110/262 (41.98%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADD-----------------KKSTKFSYA---------KTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
E+ + E+ +++++P+ + + D+ KK + A + I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ KYL + E GKV + G L+ +TY+I
Sbjct: 326 EKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEETKCEKISTLGDCYYCVAGCPEP----RADHAYCCIEMGLGMIKAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME-DGKVIER-LGQSVVADQLKGLKTYLI 571 HSP 4 Score: 56.9954 bits (136), Expect = 2.723e-7 Identity = 41/170 (24.12%), Postives = 84/170 (49.41%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFD------DFGKIMNCEKIATLGDCYYCVSGCPVPRS-------DHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y K + ++FA IV F+ + + K+ +LN+L FD D+ I EKI T+G Y SG ++ +H E M +++ FN + +RVG + G + A +IG + +D++ + V+IA+ ++++G ++ +S+++++++
Sbjct: 1050 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSI---EKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 1216
BLAST of Adenylate cyclase type vs. Ensembl Human
Match: ADCY1 (adenylate cyclase 1 [Source:HGNC Symbol;Acc:HGNC:232]) HSP 1 Score: 192.2 bits (487), Expect = 1.853e-53 Identity = 90/218 (41.28%), Postives = 144/218 (66.06%), Query Frame = 2
Query: 752 GLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESI--RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTF 1399
G+++RI ++ AFL+ + +++++ + Q + +++P V E E + +F+ Y ++ NVSILFADIVGFT ++S TA++LV LLN+L+ +FD+ +C +I LGDCYYCVSG P++DHA CCVEMGL M I + + ++NMRVG+H+GRV+ ++G ++++DV+SNDV++AN +E++G PGKVHI+K T
Sbjct: 3 GVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTL 220 HSP 2 Score: 59.6918 bits (143), Expect = 1.183e-8 Identity = 51/222 (22.97%), Postives = 98/222 (44.14%), Query Frame = 2
Query: 2459 EKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVS 3109
E++ R F +R E +R ++ E + E+ L +++P+ V ++ F Y + N ++FA I F +G + + +K+L+ + FD L +IK + DCY SGL + DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++
Sbjct: 11 ERSQRKAFLQARSCIEDRLRLED---ENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGF-TGLASQ--CTAQELVKLLNELFGKFDEL---ATENHCRRIKILGDCYYCVSGLTQP----KTDHAHCCVEMGLDMIDTITSVAEATEVD---LNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHIT 216
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Match: acy-4 (Adenylate cyclase [Source:UniProtKB/TrEMBL;Acc:Q966F9]) HSP 1 Score: 287.345 bits (734), Expect = 3.421e-81 Identity = 244/864 (28.24%), Postives = 421/864 (48.73%), Query Frame = 2
Query: 707 MLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEF---LESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTK--ERQFGLEGFAPTLVPMPTYFVESYSTEFD----EYFNRKVI---DESKSYERNEEKSNESKPSQIGIDKSAL-EFKIRDEKMKNDL-ELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIP---LIMIAGWI-----CLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYRED-YKRGESALKVLHNIICGFDNLLRLPL----YKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRP 3214
+++ ++++ +V + G + ++ F + + Q++M +D + Q + A++P + E ++ + +F+ Y ++++++SILFADI GFT ++S K LV +LN+L+ RFD I C +I LGDCYYCV G P + +HA+ VEMG M + I + VNMRVG+H+G+ ++G +++FDV+SNDV++AN +ES G G+VHI+ T + AY EG +K E++ + T+ V S ++D E N V+ ++ + E + S ++ ++ L E ++ E + + L + I+ + + +T+ C +L +K +E+ F V L + I QV + +V I A + I+ G ++ LV S +P +++ + I L+ + + S + +F++ S + L +G+Y S D EK + N YT +F + ++ C+ +S + ++ + S +L+ K + I +Y + + ++ + L LL+ F TR +E R F +A + +R+ + L NI+P +V +D S Y ++ NA ++FA++ F Y D G L++L+ II FD +L L +K +EKIKT++ YM+ASGL A + H+ + LF+ +LL +L NI +F L+IG N GPV AG+IG+ KP YDIWG++VNVASRM S AG+IQV++ V L + FE RG++ +KGKG +ET+ L P
Sbjct: 211 IILTRVMMVILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQETHEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGSRSKFLEKE-----------KIKTWLVVDRSPDYDNICQEATNHPVMVPWKSTRGISKQERLTGMSTRTRGASTRNGLSEEEVLVENVDSHLRQGIQAIHQENWKTMHC------KNWSLKYKQVRVENKF-----------------VRLKYKDIPFQV-TLYVAIVAICIGIKFGLMN----LVSFSFVPQMFIVLTSVMIFILTRALIKHARLVSLVIGVLFILLSIQIVIL-MGMYESKFTC-------DVEKCFKN-NYT-DFFEIFEICTLATCVI-LSVDFMTKLLMSMIYFSSFTVLI-TAKLIRINQYEALLSTYANFCVLSCLTL------------LLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHF---VEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGL-AGRECGDNSHVEAIALFARELLVKL---ESTNIHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFLLPP 1004 HSP 2 Score: 62.3882 bits (150), Expect = 1.855e-9 Identity = 66/287 (23.00%), Postives = 125/287 (43.55%), Query Frame = 2
Query: 695 NKYYMLIGQIILFFMVYLTGLYLRIFNSIRR----KSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAM----SSNKTAKQLVYLLNDLYNRFD----------DFGKIMNCEKIATLGDCYYCVSGCP---VPRSDH----ALCCVEMGLGM-CKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT--------FKLVCHAYTFIEGEKLMVT 1453
N+Y L+ F ++ L L +F++ R + F+ Q +++M + +E I+P+ V F+E S Y + N I+FA + F N + + LLN++ + FD +F KI EKI T+ Y SG + H AL E+ + + I +FN N+R+G++ G V+A +IG+ + +D++ N V++A+ ++S G G++ ++++ + C ++G+ +M T
Sbjct: 723 NQYEALLSTYANFCVLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKL---YHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKI---EKIKTISTTYMVASGLAGRECGDNSHVEAIALFARELLVKLESTNIHSFNNF-----NLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMET 998
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Match: acy-1 (Adenylyl CYclase [Source:UniProtKB/TrEMBL;Acc:Q19523]) HSP 1 Score: 221.861 bits (564), Expect = 8.250e-59 Identity = 166/517 (32.11%), Postives = 251/517 (48.55%), Query Frame = 2
Query: 299 DRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMV--VLCMSYSVIIGTDADEMMEARFSLMVA-------VILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLES---IRSKDLFNLGYCK-------------------QFK--------NVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTV 1732
DRT I IV+L + F T + S + ++C+ +I + +A F VA V+L++YT+ L + +L+ I+Y ++F ++GL E+ Y+ +++L V+L G++L I +R++ FLK+ Q+ A+ ++ + + + I+++MP V E L+ +R N C+ +F+ NVSILFADI GFT MSSNK+A +LV LLNDL+ RFD ++ EKI+TLGDCYYCV+GCP P DHA VEMGL M I F+ +EVNMRVG+H+G+V+ ++G RF+FDV+SNDV++AN +ESSG G+VH+S+ T KL+ Y EG Q ++G + P ES T +F + I++ E + + ES SQ KS L+ K EK+K + H S P R
Sbjct: 88 DRTFIQHWIVSLCLCAIIFAMFAFTACAAQYQRFYMPTSFLCTFLICLVTLLIFSAEN----QAAFMTPVASLATSFQVVLLIYTVIPLPLYLCILIGIIYSILFEILNKNKIGLEEAG-------------------------YI---KLVLHAGVHLLGVHLFILTQVRQRKTFLKVGQSMLARKDLELETQFKDHMIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQ--VQGTERRVKP------ESMKT----FFIKGRINDGVEEEVMQVQEVESLHSQKSSKKSTLKQKWA-EKLK-----MNHTNSYPMRAA 554 HSP 2 Score: 174.096 bits (440), Expect = 8.238e-44 Identity = 106/264 (40.15%), Postives = 156/264 (59.09%), Query Frame = 2
Query: 2429 LLLYFLTRENEKNIRIFFYASREAEIRNDEARRE--RKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKA---YREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKG-KGDVETYL 3202
+L+ FL + E R+ F+ +A R D R + R A+ L N+IP + + K TK+S V GV+FASI N+ + Y E+++ G L+VL+ +I FD LL P + +EKIKT+ YM ASGLN K + ++HLY+++ F+ + + L+ +NE+ + N F K+G N GPVTAG+IGT+K YDIWGDTVN+ASRMYST +IQVS + +YL + FE+R + +KG G ++TYL
Sbjct: 982 VLVAFLNYQFETAFRMSFFGDVQA--RRDTERMQIVRDQADWLLNNVIPAHAVESL------KTDTKYSENHETV--GVLFASITNW-NDMYEENFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQHVLSVFNEDLL--NFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEFEFRDHIEVKGIDGGMDTYL 1232 HSP 3 Score: 71.633 bits (174), Expect = 2.775e-12 Identity = 56/233 (24.03%), Postives = 109/233 (46.78%), Query Frame = 2
Query: 2642 IVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSEYQKM*NSLKVACNYNQRVTKR 3328
+ N ++FA I F K + + +L+++ FD L RL +GLEKI T+ DCY +G +DH + + D++ + ++ I + +++G + G V G++GT + +D++ + V +A+ M S+ AG++ VS+ K L + E Y G + M+ +G T ++P + G+ E + M +V ++Q+ +K+
Sbjct: 315 MTNVSILFADIAGFTK---MSSNKSADELVNLLNDLFGRFDTLCRL---RGLEKISTLGDCYYCVAGCPEPC----DDHACRTVEMGLDMIVAIRQFD---IDRGQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQG---TERRVKPESMKTFFIKGRINDGVEEEVM-QVQEVESLHSQKSSKK 530 HSP 4 Score: 60.8474 bits (146), Expect = 5.403e-9 Identity = 49/207 (23.67%), Postives = 98/207 (47.34%), Query Frame = 2
Query: 848 IKVQIYWI-EAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSN--KTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRS-------DHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF 1426
++ Q W+ ++PA +ES+++ + Y + + V +LFA I + M + ++ + +LN++ FD D + EKI T+G Y SG R +H V+ L + ++ FN L + ++G++ G V A +IG + +D++ + V+IA+ + S+G ++ +S+ T + + Y F
Sbjct: 1015 VRDQADWLLNNVIPAHA----VESLKT----DTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEF 1213
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Match: acy-2 (Adenylyl CYclase [Source:UniProtKB/TrEMBL;Acc:O16880]) HSP 1 Score: 162.54 bits (410), Expect = 2.781e-40 Identity = 78/172 (45.35%), Postives = 113/172 (65.70%), Query Frame = 2
Query: 920 RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
++ LF+ + + NVSILFADIV FT +++ TAK LV LN+LY++FD + + C +I LGDCYYCVSG PV R +HA CV MGL M I +VNMR+GVH+G V+ I+G +++FD++S+DV++AN +ES+G PG VHI+K T ++ Y ++
Sbjct: 297 KNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGDYCIVDA 468 HSP 2 Score: 124.405 bits (311), Expect = 1.718e-28 Identity = 88/264 (33.33%), Postives = 136/264 (51.52%), Query Frame = 2
Query: 2483 YASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYK---------------------LML-FSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKG-KGDVETYL 3202
+ S + E R+ E ++ + + + NI+P V + + D+ + YA+ N V+FASI NF + D R L++L+ I+C FD LL P + +EKIKTV YM A+GLN S Y + +L K LM+ F+ + L N ++ ++F L+IG + GP+ AG+IG KP YDIWG+TVN+ASRM + KI + + + L T + + RGK+ +KG K +ET+L
Sbjct: 797 HVSFQNEERDVETMQD--INKILIENILPSSVAAKFL--SPDRAVNEL-YARQHENVCVMFASIPNFKDFWSEWDTNRKLECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRHGNMAFRNANLMIEFALAMSQILDALNRDSF---QNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETFL 1052 HSP 3 Score: 80.1073 bits (196), Expect = 7.518e-15 Identity = 55/205 (26.83%), Postives = 99/205 (48.29%), Query Frame = 2
Query: 869 IEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSN-KTAKQL--VYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGCPVPRSDH--------------------------ALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHIS 1387
IE I+P++V +FL R+ N Y +Q +NV ++FA I F S T ++L + LLN++ FD K + EKI T+G Y +G +D+ A +E L M +++ A NR + +R+G+ G ++A +IG + ++D++ N V++A+ +++ G+P K+H +
Sbjct: 818 IENILPSSVAAKFLSPDRA---VNELYARQHENVCVMFASIPNFKDFWSEWDTNRKLECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRHGNMAFRNANLMIEFALAMSQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHAT 1019 HSP 4 Score: 56.6102 bits (135), Expect = 1.045e-7 Identity = 53/226 (23.45%), Postives = 93/226 (41.15%), Query Frame = 2
Query: 2495 EAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--------------------YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFD-NLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVS 3109
EA R E + E+ L ++IP Y+ Q++ S ST + + + N ++FA I NF + K ++ L+ + FD + RL + IK + DCY SG+ + R +H ++ +++N + + I ++IG + G V GI+G K +DIW D V +A+ M S G + ++
Sbjct: 241 EAVYRRTELETLKDRQEQLLLSVIPAYLADQVSKSIIQSSSTGSTVEVPRTGKNNTKNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAK---DLVRTLNELYSKFDRDAQRLQCMR----IKFLGDCYYCVSGMPVN----RPNHADMCVVMGLEMINTI---KQVRIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHIT 452
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 119.783 bits (299), Expect = 5.600e-27 Identity = 66/185 (35.68%), Postives = 106/185 (57.30%), Query Frame = 2
Query: 968 VSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHK--EEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF---IEGEKLMVTKERQ--FGLEGFAPTLVP 1501
V+I F+DIVGFT++SS T Q+V LLNDLY FD K+ T+GD Y VSG P R DHA +M L + + F H+ E++ +R+G+HSG V+A ++G+ R+ ++ + V+ ++ +ES+G P K+H+S++T+ ++ F + G M K Q + L G+ +P
Sbjct: 1085 VTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKDVEIP 1269 HSP 2 Score: 84.7297 bits (208), Expect = 2.679e-16 Identity = 76/256 (29.69%), Postives = 122/256 (47.66%), Query Frame = 2
Query: 2501 EIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLL-RLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIV----GNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH--FLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGK 3247
E R E E+K E+ L+ ++P + AD + + A++ + F+ I F S + + + +L+++ FD ++ +YK ++T+ D YM+ SGL R+DH ++ S LL+++ +N V ++ L+IG + G V AG++G+ P Y ++GDTVN +SRM S KI VS + L F E RG V MKGKG TY LR Y+ I G+
Sbjct: 1042 EERTQEYLAEKKKVEELLHQLLPPAI-------ADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQ---VVTLLNDLYLAFDGVVDNFKVYK----VETIGDAYMVVSGL----PERRDDHANQIAQMSLSLLHKV-----KNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYW-LRGYKDVEIPDFGE 1273
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 119.398 bits (298), Expect = 7.078e-27 Identity = 66/185 (35.68%), Postives = 106/185 (57.30%), Query Frame = 2
Query: 968 VSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHK--EEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF---IEGEKLMVTKERQ--FGLEGFAPTLVP 1501
V+I F+DIVGFT++SS T Q+V LLNDLY FD K+ T+GD Y VSG P R DHA +M L + + F H+ E++ +R+G+HSG V+A ++G+ R+ ++ + V+ ++ +ES+G P K+H+S++T+ ++ F + G M K Q + L G+ +P
Sbjct: 1047 VTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKDVEIP 1231 HSP 2 Score: 84.7297 bits (208), Expect = 3.385e-16 Identity = 76/256 (29.69%), Postives = 122/256 (47.66%), Query Frame = 2
Query: 2501 EIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLL-RLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIV----GNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH--FLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGK 3247
E R E E+K E+ L+ ++P + AD + + A++ + F+ I F S + + + +L+++ FD ++ +YK ++T+ D YM+ SGL R+DH ++ S LL+++ +N V ++ L+IG + G V AG++G+ P Y ++GDTVN +SRM S KI VS + L F E RG V MKGKG TY LR Y+ I G+
Sbjct: 1004 EERTQEYLAEKKKVEELLHQLLPPAI-------ADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQ---VVTLLNDLYLAFDGVVDNFKVYK----VETIGDAYMVVSGL----PERRDDHANQIAQMSLSLLHKV-----KNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYW-LRGYKDVEIPDFGE 1235
BLAST of Adenylate cyclase type vs. Ensembl Fly
Match: Ac13E (gene:FBgn0022710 transcript:FBtr0332497) HSP 1 Score: 246.899 bits (629), Expect = 2.413e-66 Identity = 133/344 (38.66%), Postives = 194/344 (56.40%), Query Frame = 2
Query: 482 ARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-----------------------SIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKL 1444
F++ + ++L++YT + + +I Y + F + +G + + A + P+ +LI +I+ V+L G+++ I N +R + F+K+ QN + +++ +++ I ++MP V L S K LF + +NVSILFADIVGFT MSS KTA+QLV +LNDL+ RFDD + CEKI+TLGDCYYCVSGCP PR+DHA+CCVEMGLGM + F+ E V MRVGVH+G V+ I+G R +FDV+SNDVS+AN +ESSGKP +VHIS++T + AY EGE++
Sbjct: 183 GHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNR-ILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEV 525 HSP 2 Score: 166.777 bits (421), Expect = 3.201e-41 Identity = 98/251 (39.04%), Postives = 142/251 (56.57%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYL 3202
RE E R+ FY + A + + A+ L+NIIPK+V + +A Y++ N ++FASI NF + Y E Y G+ L+VL+ +I FD LL P ++ +EKIKT+ +M ASGL+ S + ++H++ LM FS + + +N++ + N L+IG N G VTAG+IGTSK YDIWGD VNVASRM ST +IQV +L + FE RG V++KGK +E +L
Sbjct: 1336 REFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTA--------KYSENHHNIAIIFASIVNF-NEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFN--LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKGKDHMEVFL 1575 HSP 3 Score: 76.6406 bits (187), Expect = 1.282e-13 Identity = 48/170 (28.24%), Postives = 90/170 (52.94%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGC-PVPRS---DHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF 1426
Y + N++I+FA IV F M S K+ + +LN+L FD+ + EKI T+G + SG P R +H +E + M +++ AFN+ L + + +R+G++ G V A +IG + +D++ + V++A+ ++S+G P ++ + K + + Y F
Sbjct: 1388 YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEF 1557 HSP 4 Score: 72.7886 bits (177), Expect = 1.706e-12 Identity = 50/205 (24.39%), Postives = 97/205 (47.32%), Query Frame = 2
Query: 2558 NIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVF 3169
+ P+ + + S D K + + ++ N ++FA I G+ R K E +++L+++ FD+L L G EKI T+ DCY SG R DH + +++ + ++ + G K +++G + G V GI+GT + +D+W + V++A++M S+ ++ +S +L + E +VF
Sbjct: 336 GLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADI----VGFTRMSSTKTAEQLVEILNDLFERFDDLCSL---SGCEKISTLGDCYYCVSGC----PEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVK---MRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVF 526
BLAST of Adenylate cyclase type vs. Ensembl Fly
Match: Ac13E (gene:FBgn0022710 transcript:FBtr0074073) HSP 1 Score: 246.514 bits (628), Expect = 2.705e-66 Identity = 133/344 (38.66%), Postives = 194/344 (56.40%), Query Frame = 2
Query: 482 ARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-----------------------SIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKL 1444
F++ + ++L++YT + + +I Y + F + +G + + A + P+ +LI +I+ V+L G+++ I N +R + F+K+ QN + +++ +++ I ++MP V L S K LF + +NVSILFADIVGFT MSS KTA+QLV +LNDL+ RFDD + CEKI+TLGDCYYCVSGCP PR+DHA+CCVEMGLGM + F+ E V MRVGVH+G V+ I+G R +FDV+SNDVS+AN +ESSGKP +VHIS++T + AY EGE++
Sbjct: 170 GHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNR-ILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEV 512 HSP 2 Score: 166.392 bits (420), Expect = 3.527e-41 Identity = 98/251 (39.04%), Postives = 142/251 (56.57%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYL 3202
RE E R+ FY + A + + A+ L+NIIPK+V + +A Y++ N ++FASI NF + Y E Y G+ L+VL+ +I FD LL P ++ +EKIKT+ +M ASGL+ S + ++H++ LM FS + + +N++ + N L+IG N G VTAG+IGTSK YDIWGD VNVASRM ST +IQV +L + FE RG V++KGK +E +L
Sbjct: 1323 REFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTA--------KYSENHHNIAIIFASIVNF-NEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFN--LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKGKDHMEVFL 1562 HSP 3 Score: 76.6406 bits (187), Expect = 1.247e-13 Identity = 48/170 (28.24%), Postives = 90/170 (52.94%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGC-PVPRS---DHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF 1426
Y + N++I+FA IV F M S K+ + +LN+L FD+ + EKI T+G + SG P R +H +E + M +++ AFN+ L + + +R+G++ G V A +IG + +D++ + V++A+ ++S+G P ++ + K + + Y F
Sbjct: 1375 YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEF 1544 HSP 4 Score: 72.7886 bits (177), Expect = 1.885e-12 Identity = 50/205 (24.39%), Postives = 97/205 (47.32%), Query Frame = 2
Query: 2558 NIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVF 3169
+ P+ + + S D K + + ++ N ++FA I G+ R K E +++L+++ FD+L L G EKI T+ DCY SG R DH + +++ + ++ + G K +++G + G V GI+GT + +D+W + V++A++M S+ ++ +S +L + E +VF
Sbjct: 323 GLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADI----VGFTRMSSTKTAEQLVEILNDLFERFDDLCSL---SGCEKISTLGDCYYCVSGC----PEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVK---MRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVF 513
BLAST of Adenylate cyclase type vs. Ensembl Fly
Match: Ac13E (gene:FBgn0022710 transcript:FBtr0100142) HSP 1 Score: 246.514 bits (628), Expect = 2.705e-66 Identity = 133/344 (38.66%), Postives = 194/344 (56.40%), Query Frame = 2
Query: 482 ARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-----------------------SIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKL 1444
F++ + ++L++YT + + +I Y + F + +G + + A + P+ +LI +I+ V+L G+++ I N +R + F+K+ QN + +++ +++ I ++MP V L S K LF + +NVSILFADIVGFT MSS KTA+QLV +LNDL+ RFDD + CEKI+TLGDCYYCVSGCP PR+DHA+CCVEMGLGM + F+ E V MRVGVH+G V+ I+G R +FDV+SNDVS+AN +ESSGKP +VHIS++T + AY EGE++
Sbjct: 170 GHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNR-ILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEV 512 HSP 2 Score: 166.392 bits (420), Expect = 3.527e-41 Identity = 98/251 (39.04%), Postives = 142/251 (56.57%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYL 3202
RE E R+ FY + A + + A+ L+NIIPK+V + +A Y++ N ++FASI NF + Y E Y G+ L+VL+ +I FD LL P ++ +EKIKT+ +M ASGL+ S + ++H++ LM FS + + +N++ + N L+IG N G VTAG+IGTSK YDIWGD VNVASRM ST +IQV +L + FE RG V++KGK +E +L
Sbjct: 1323 REFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLKNTA--------KYSENHHNIAIIFASIVNF-NEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFN--LILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKGKDHMEVFL 1562 HSP 3 Score: 76.6406 bits (187), Expect = 1.247e-13 Identity = 48/170 (28.24%), Postives = 90/170 (52.94%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGC-PVPRS---DHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF 1426
Y + N++I+FA IV F M S K+ + +LN+L FD+ + EKI T+G + SG P R +H +E + M +++ AFN+ L + + +R+G++ G V A +IG + +D++ + V++A+ ++S+G P ++ + K + + Y F
Sbjct: 1375 YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEF 1544 HSP 4 Score: 72.7886 bits (177), Expect = 1.885e-12 Identity = 50/205 (24.39%), Postives = 97/205 (47.32%), Query Frame = 2
Query: 2558 NIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVF 3169
+ P+ + + S D K + + ++ N ++FA I G+ R K E +++L+++ FD+L L G EKI T+ DCY SG R DH + +++ + ++ + G K +++G + G V GI+GT + +D+W + V++A++M S+ ++ +S +L + E +VF
Sbjct: 323 GLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADI----VGFTRMSSTKTAEQLVEILNDLFERFDDLCSL---SGCEKISTLGDCYYCVSGC----PEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVK---MRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVF 513
BLAST of Adenylate cyclase type vs. Ensembl Fly
Match: ACXB (gene:FBgn0040509 transcript:FBtr0080414) HSP 1 Score: 233.417 bits (594), Expect = 1.202e-62 Identity = 242/922 (26.25%), Postives = 401/922 (43.49%), Query Frame = 2
Query: 746 LTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLF----------------NLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTF-KLVCHAYTFIEGEKLMVTKERQFGLEGFAPTL--VPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDL---ELIRHLQSDPE-----RTVQCFQNP-------PLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKT-----TTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSR--LSIGIYISVLPT--LLVHT-LYDAEKLYNNYEYTVGYFTLTFFALIS-NC----IFT--------ISYS------VLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLL---YFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRL-PLYKGLEKIKTVNDCYMMASGLN--------------------------ASSKAYREDH---LYKLMLFSFDLLNQLAYYNEENIVGNKHF-------YLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
L G++ RI N +S+FL Q + +M + A + + +++I+P + +SI+ + + N + +VSIL+AD+V +T +++ T ++LV +L+DLY RFD ++I LGDCYYCV+G DHA V +G+ M I +++MR+GVHSG ++A +IG + ++D++ DV IAN LE++GKPG VH+S +T L YT G ++ + P L PM TY + + + RN +S ++ S ID +AL + ++ L EL + P R+ C N L + FKD+ +E + H D I + ++ L I C + ++ F + +E I T+L+++S + W C+ S + K+F I+ L + IY+S++ + LL+ T L + +K N YE V L + +++ NC +FT +SY+ LK + T T L ++ ++YS F+ ++ T +K + L ++C++L Y R++E N +I F +++ + + A K L NI+P +V S + + Y + V+FA + NF + +L+VL++II FD LL Y +EKIK V YM A GL+ SK DH + + F+ DL+ L+ N+ + F + IG + G + AG++G S+P YDIWG+ VN+ASRM ST G I V+ L + YRG F+KG+G++ TY
Sbjct: 216 LMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSD----------PILQKQPMTTYLLTAAPS------------------RNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSY-LHKPDFILKYSV------LLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFK--KVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDK--NQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVF--------FQYS----FIFEHSATTTPFMKAELAHCL-RVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHE----LYYENYKMVSVMFAMLINF---------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKA--YAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTY 1070
BLAST of Adenylate cyclase type vs. Ensembl Fly
Match: ACXC (gene:FBgn0040508 transcript:FBtr0080413) HSP 1 Score: 231.876 bits (590), Expect = 5.321e-62 Identity = 245/918 (26.69%), Postives = 397/918 (43.25%), Query Frame = 2
Query: 746 LTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSK--------DLFNLG--------YCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHA-YTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV------ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGI-DKSALEFKIRDEKMKN-DLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIRE--------ININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAG-WICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTL--------------LVHTLYDAEKLYN-NYEYTVGYFTLTFFALISNCIFTISYSVLK----QMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRL-PLYKGLEKIKTVNDCYMMASGL--NASSKAYREDH--------------------------------LYKLMLFSFDLLNQLAYYN--------EENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETY 3199
+ G++ RI N +++FL Q + + A+ + +++I+P + E I+SK D F +G + +VSIL+AD+V +T +++ T LV +L+DLY RFD ++I LGDCYYCV+G P DHA CCV +G+ M I +++MR+GVHSG ++A IIG + +FD++ DV IAN LES+G+PG VH+S +T ++ A YT + G T++ Q P L + TY + ES+ T + V+ E KS +R S+PSQ + D+ EF+ N + R + D + Q + FKD+ +E ++ H D I + I + + + + +C C +++ FFL + SG I G + C+ + IF KI H +S L I +Y+ +L + + Y K+Y+ + + F +IS I ISY+ + +C YLL+ + I+++S+ + K + ++ + L +Y R++E N ++ + + + + + A + L NI+P +V S + Y + V+FA + NF +L+VL++II FD LL Y +EKIK V YM A GL N +S + DH ++ + F+ DL+ LA N E ++ K + IG + G + AG++G S+P YDIWG+ VN+ASRM ST G IQV++ K L F+ YRG F+KG+GD+ TY
Sbjct: 225 MMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSG-----TQKAQSD-----PVLQYIHTYLLTGQVARESFITSIGGVRSSSVL-EVKSIDR----IRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQ----REIGIFCAAFKDSSLEWNY-LHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAF------HIFEKI----QHSVS-LRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMIS-LILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFM--------KAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHE----LYYENYRMVSVMFAMLINF---------PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGK---ICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQE---FDIKCIYRGMTFVKGRGDIPTY 1083
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Match: adcy9 (adenylate cyclase 9 [Source:ZFIN;Acc:ZDB-GENE-050208-455]) HSP 1 Score: 373.629 bits (958), Expect = 1.860e-109 Identity = 305/983 (31.03%), Postives = 473/983 (48.12%), Query Frame = 2
Query: 704 YMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFL-----ESIRSKDLFNLGYC-----------------------------------KQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT---------------FKLVCHAYT---------FIEGEKL-------MVTKERQFGLEGFAP---TLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESK-PS-----------------QIGIDKSALEFKIRDE--------------------------KMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQV------CSTFVIIS-AFFLIIESGGISKTTTLVYMSGIPLI-------MIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGY-FTLTFFALISNCIFTISYSVLKQMS----TAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQI---------CLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYL 3202
++ G+ +L ++ G+++ I + +R +S FLK+ Q ++ ++ I ++MP +V E + ES S ++ G C K+ + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD ++ +CEKI+TLGDCYYCV+GCP P +DHA CCVEMGLGM + I F + E VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVH+S+ T + V H+ T I G KL ++ ++FG E +P T P T+ V + D N + +++ ++E ++N SK P+ ++G+ +S+L K++++ + K+D + ++ D F PP+N L+L F + +ES ++ +Q+ +N V V F + + C+ F+ ++ A FL +S T L G+ + + I +++ + R + + S + R IG + LP + V +++ Y++ +T F + I I Y Q+S +A T L LL I YS+ + T +L S L + LL++FL RE E + R+ ++ + EA+ + + R A+ L NIIP +V Q+ SY+K N GV+FASI NF S +Y E Y+ G+ +VL+ +I FD LLR P + +EKIKT+ YM ASGLN + + HL L F+ +++ + +N+ N++G K F L+IG+N GP+TAG+IGT+K LYDIWGDTVN+ASRM ST +IQVS+ H L+ ++ F+YRG V +KGKG + TYL
Sbjct: 290 WLGPGKFLLHLCAHVVGIHIFIMSEVRSRSTFLKVGQAIMHGKDLEVEKALKERMIHSVMPRSVADELMKQGDEESESSGKRYSAGTCSVAAAAAVTSSSPKSHKRKKNSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTSCEKISTLGDCYYCVAGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHTGTVLCGILGMKRFKFDVWSNDVNLANLMEQLGVAGKVHLSEVTAGFLDDRYEREDGRVIERVGHSVTDQLKGLKTYLISGRKLGSQCGCSQLSLGQEFG-ETLSPSSNTHTPDHTHCVIAEPQSHDVVDNPTTDEATQNGCQDEHRANSSKFPAGRSPKTLNGLLSPLCEERVGVSQSSLCDKLQEKDRSWAGSLAAEGKDHSAILPLRSKNFREKSDAHFVEVIKED-SLMKDYFFKPPINKLSLNFLEKSLESAYRTSYHEQV----MNHVPVQTFASPVFSSLLDVLLSCTVFLALTMACFLYPL---VSMQTPLAATLGLAITAALLELVSLLLSIRMIFCLDDVQNCSRILLKLVSGWVPRHVIGAVLVSLPAVSV---------FSHLAYSLQLPIQVTMFLCCALIIAIIQYCTFCQLSFWMRSALATVVGLSLL--------ILLYSASIR--TSPKTCSTVELDRLNSLDLLVLETVLSFFLLLLLVWFLNREFEVSYRLHYHGNVEADKHRIKIQTMRDQADWLLRNIIPIHVAEQL--------KVNQSYSKNHDNVGVIFASIVNF-SEFYEESYEGGKECYRVLNELIGDFDELLRQPAFSNVEKIKTIGATYMAASGLNGQQCQEQPHPHAHLCALFDFALEMMRVVDDFNK-NMLGFK-FKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEESHCVLSRMNYAFDYRGTVNVKGKGQMRTYL 1233
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Match: si:ch211-132f19.7 (si:ch211-132f19.7 [Source:ZFIN;Acc:ZDB-GENE-130530-619]) HSP 1 Score: 320.472 bits (820), Expect = 1.264e-91 Identity = 248/877 (28.28%), Postives = 421/877 (48.00%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD------LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGE-----------KLMVTKERQFGLEGFAPTLVPMPTYFVESYSTE--FDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHP-------LSRLSIGIYISVLPTLLVH---TLYDAEKLYNNYE----YTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFL-----TRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYY--REDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED--HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETY 3199
L+ + +L+ + GL++ + ++ AFL+ + + ++KM+ + Q + +I+P + E + + + D F+ Y Q+K+VSILFADI GFT++S A++LV LN+L+ RFD + +C +I LGDCYYCVSG P P++ HA CCVEMGL M I + K +++MR+G+HSG V+ ++G +++FDV+S DV +AN LE+ G PG++HIS+ T + Y EG K+ R + P V + ++S E FD I + + N+ P G + ++++K +E+ R+ + + + P TL FKDT IE F Q+R+ +F +AC I++A LI + + ++++ + +K P + + + H L+ +I I V + T + EK N E + V T F ++S + ++ +V ++S C L L + E + V F+ + Q Q+ +Y + + + ++ + +R+ E R+ F +A ++ + R+ E LYNI+P +V + ++ + ++++ GV+FASI FS YY +E + L++L+ II FD LL P ++ +EKIKT+ CYM ASGL+ + ++ HL L+LF+ + L N+ + F+L++G + GPV AG+IG +KP YDIWG TVN+ASRM ST +G+IQV + + LA H F+ + RG++++KG +G V TY
Sbjct: 293 LLAKGLLYMGMNTAGLFIHYLSDRAQRQAFLETRRCIEGRVKMERENQRQERLVMSILPRFIAMEMIGDMTALDDELLPQQFHKTYFHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGVPEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDVANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERNEFLRKHKIDTFLIRHTPQDDKEPPKVRRTSKDETTWSAELPFDNIIGMNCILATFTNGSLVHLPNQITPHCAGSREI-------NKRIKQAIEV---------RSSERMRKEHITPFTLVFKDTHIEGKF-----SQMRD--------EMFKSNLACSFLLLLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLVTLAEEFKRSPP---YLQHLCCWIHETKSIRNLLTLTAIAINFGVASCNIFWCNGTFEETEKSNKNSEHGKQWPVNICTHPEFFVLSGVVAMVTCAVFLRLS---CLLKLAVLTLVIAVYTYLIEVAFHVLFIRQHQNSQIQRSQYLRRKGISVLLMAMFVVVVLYNSRQLETTSRLDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFL---ERDRNNEDLFSESYERVGVMFASIPG-FSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRT---SNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTY 1127 HSP 2 Score: 81.2629 bits (199), Expect = 5.220e-15 Identity = 64/234 (27.35%), Postives = 113/234 (48.29%), Query Frame = 2
Query: 878 IMPAAVRGEFLESIRS-KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVY-------LLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRSD------HALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVC-HAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVES 1525
I+PA V FLE R+ +DLF+ Y + V ++FA I GF S K+L++ LLN++ FD D + EKI T+G CY SG + + H V L M + + N+ + +RVG+ G V+A +IG + ++D++ V++A+ ++S+G G++ + + T +++ H + M+ + ++G + + TYFV S
Sbjct: 913 ILPAHVARHFLERDRNNEDLFSESY----ERVGVMFASIPGF---SDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSGRIQVPEATSRVLAEHGF--------MLQLRGEIYVKGVSERRGAVRTYFVSS 1131
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Match: si:ch211-132f19.7 (si:ch211-132f19.7 [Source:ZFIN;Acc:ZDB-GENE-130530-619]) HSP 1 Score: 320.472 bits (820), Expect = 1.264e-91 Identity = 248/877 (28.28%), Postives = 421/877 (48.00%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD------LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGE-----------KLMVTKERQFGLEGFAPTLVPMPTYFVESYSTE--FDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHP-------LSRLSIGIYISVLPTLLVH---TLYDAEKLYNNYE----YTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFL-----TRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYY--REDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED--HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETY 3199
L+ + +L+ + GL++ + ++ AFL+ + + ++KM+ + Q + +I+P + E + + + D F+ Y Q+K+VSILFADI GFT++S A++LV LN+L+ RFD + +C +I LGDCYYCVSG P P++ HA CCVEMGL M I + K +++MR+G+HSG V+ ++G +++FDV+S DV +AN LE+ G PG++HIS+ T + Y EG K+ R + P V + ++S E FD I + + N+ P G + ++++K +E+ R+ + + + P TL FKDT IE F Q+R+ +F +AC I++A LI + + ++++ + +K P + + + H L+ +I I V + T + EK N E + V T F ++S + ++ +V ++S C L L + E + V F+ + Q Q+ +Y + + + ++ + +R+ E R+ F +A ++ + R+ E LYNI+P +V + ++ + ++++ GV+FASI FS YY +E + L++L+ II FD LL P ++ +EKIKT+ CYM ASGL+ + ++ HL L+LF+ + L N+ + F+L++G + GPV AG+IG +KP YDIWG TVN+ASRM ST +G+IQV + + LA H F+ + RG++++KG +G V TY
Sbjct: 293 LLAKGLLYMGMNTAGLFIHYLSDRAQRQAFLETRRCIEGRVKMERENQRQERLVMSILPRFIAMEMIGDMTALDDELLPQQFHKTYFHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGVPEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDVANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERNEFLRKHKIDTFLIRHTPQDDKEPPKVRRTSKDETTWSAELPFDNIIGMNCILATFTNGSLVHLPNQITPHCAGSREI-------NKRIKQAIEV---------RSSERMRKEHITPFTLVFKDTHIEGKF-----SQMRD--------EMFKSNLACSFLLLLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLVTLAEEFKRSPP---YLQHLCCWIHETKSIRNLLTLTAIAINFGVASCNIFWCNGTFEETEKSNKNSEHGKQWPVNICTHPEFFVLSGVVAMVTCAVFLRLS---CLLKLAVLTLVIAVYTYLIEVAFHVLFIRQHQNSQIQRSQYLRRKGISVLLMAMFVVVVLYNSRQLETTSRLDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFL---ERDRNNEDLFSESYERVGVMFASIPG-FSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRT---SNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTY 1127 HSP 2 Score: 81.2629 bits (199), Expect = 5.220e-15 Identity = 64/234 (27.35%), Postives = 113/234 (48.29%), Query Frame = 2
Query: 878 IMPAAVRGEFLESIRS-KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVY-------LLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRSD------HALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVC-HAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVES 1525
I+PA V FLE R+ +DLF+ Y + V ++FA I GF S K+L++ LLN++ FD D + EKI T+G CY SG + + H V L M + + N+ + +RVG+ G V+A +IG + ++D++ V++A+ ++S+G G++ + + T +++ H + M+ + ++G + + TYFV S
Sbjct: 913 ILPAHVARHFLERDRNNEDLFSESY----ERVGVMFASIPGF---SDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSGRIQVPEATSRVLAEHGF--------MLQLRGEIYVKGVSERRGAVRTYFVSS 1131
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Match: adcy3a (adenylate cyclase 3a [Source:ZFIN;Acc:ZDB-GENE-111027-6]) HSP 1 Score: 310.842 bits (795), Expect = 1.551e-88 Identity = 260/897 (28.99%), Postives = 409/897 (45.60%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSK------DLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIE----GEKLMVTKERQFGLEGFAPTLVPMPT---------YFVESY---------STEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSA-LEFKIRDEKMKNDLELIRHLQSD--PERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLT----FFALISNCIFTISY----SVLKQMSTAACTAGS-------LYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKL-----KYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGE-SALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNAS--------------SKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
L+ ++++ G+ + + AFL+ Q+ + K+ ++ + Q + +I+P + E L+ ++ + FN Y + +NVSILFADIVGFT +SS+ +A++LV LLN+L+ RFD + +I LGDCYYC+ G P R DHA C + MGL M + I + +V+MRVGVHSG V+ ++G R+++DV+S DV++AN +E+ G PG+VHIS+ T + + H +E G++ KER G+E + L P V S +TE + + E + N S P+ + L ++ D + +N+ EL + L TVQ + N L+L F D E+E+ F Q A +C C + + +I+ ++ TL + LI+ IC + + I +F K V FS + + + + TL D + + T I C Y +VL ++T S + L+ T ++IY +S D L D + ++ KY S +F + + Y+ +R EK R F E + ++ R+ E + N++P++V GS KK + Y+++ GV+FASI NF Y E G L+ L+ II FD+LL P ++ + KIKT+ YM ASG+ + S R HL L F+ + L N ++ +F L+IG N G V AG+IG KP +DIWG+TVNVASRM ST G IQV + + L + F F RG +F+KGKG++ TY
Sbjct: 226 LLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECL-HGEFDVEPGNGGDRCEYLKER--GIETYLVVLPKGPVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQ-ENEQELNKLLNEALLERETVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSGA-------------AFSCS-CVVLLFTAVMEALIDPWLVANYVTLAVGEVLLLILT---ICSL--AAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFIAVLALIATTMLVQVSHMVKLTLMLLITVATGAVNIYSWSQTFD-LYDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGS---KKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSF---NNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTY 1092 HSP 2 Score: 75.485 bits (184), Expect = 3.187e-13 Identity = 66/266 (24.81%), Postives = 118/266 (44.36%), Query Frame = 2
Query: 2456 NEKNIRIFFYASREAEIR-NDEARRERKVAEKFLYNIIPKYV----FFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
+ K+ + F A + E++ N E + +++ E+ L +I+PK++ + A K+ +F+ Y N ++FA I F + +K+L+ + FD L Y L +IK + DCY GL YREDH ++ ++ ++Y E+ +++G + G V G++G + YD+W V VA++M + G++ +S + L F E GD YL R ETY++
Sbjct: 248 DRKHRKAFLEARQSLEVKLNLEEQSQQQ--ERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQ---LSSSCSAQELVKLLNELFARFDKLA--AKYHQL-RIKILGDCYYCICGL----PDYREDHAACSIMMGLAMVEAISYVREKT---QTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVE------PGNGGDRCEYLKERGIETYLV 492 HSP 3 Score: 65.4698 bits (158), Expect = 3.615e-10 Identity = 83/381 (21.78%), Postives = 155/381 (40.68%), Query Frame = 2
Query: 515 MMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIY----WIEAI----MPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGF----TAMSSNKTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCV------------------EMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT--------FKLVCHAYTFIEGEKLMVT---KERQFGLEGFAPTLVPMPTYFVES 1525
M+ + H+ L MLL I + AVN + +++T+F + + +P+KY M +++F M+ + R + R K+ + Q K ++Y W EA+ +P V FL S + + Y + + + ++FA I F T S N + + LN++ + FD D + KI T+G Y SG + + C+ + L M ++ N +R+G++ G V+A +IG + FD++ N V++A+ +ES+G G + + + F+ V F++G+ ++T K R+ + V +P V+S
Sbjct: 763 MLVQVSHMVKLTLMLL----ITVATGAVNIYSWSQTFDLYDLTRFK------EYRVNLVPSKYTM---SVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQ---------KEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL---YSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGREKQGSFINGSFVTLPHQVVDS 1118
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Match: adcy2a (adenylate cyclase 2a [Source:ZFIN;Acc:ZDB-GENE-061109-1]) HSP 1 Score: 300.827 bits (769), Expect = 3.373e-85 Identity = 254/881 (28.83%), Postives = 412/881 (46.77%), Query Frame = 2
Query: 704 YMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV------------RGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLE--GFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKS----------------------YERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQT----QKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY-KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNAS-SKAYRED------HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
+ ++ +I+F + G Y + + K + ++ +K++ + Q + +++PA + +G + + + F+ Y ++ NVSIL+ADIVGFT ++S+ + +LV++LN+L+ +FD K C +I LGDCYYCVSG P +HA CV+MGL MC+ I E++MRVGVHSG V+ +IG ++++DV+S+DV++AN +E+ G PG+VHI+ +T + + AY +G +ER L+ G LV P VE S + Y R ID +K + R+ + K + + F+ R E+ K+ + R + ER ++ F L +D + S F FH ++ E + + F I C F I L++ S + S + A W+ I R +I S P R+++ + + L +L+ +++ +Y Y +G + + F I+Y + + A S+ +L +D EYS FL I+ + LK S LF + L L R+NE R+ F + + +E + L N++P +V A + K+ Y ++ V+FASI +F Y D K G L++L+ II FD LL P + G+EKIKT+ YM A+GLNA+ Y ++ H+ ++ F+F L+ +L N+ + F L++G N GPV AG+IG KP YDIWG+TVNVASRM ST GKIQV++ L T + RG + +KGKG+++TY
Sbjct: 239 WQILANVIIFICGNVAGAYHKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQVENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHG----QERDPYLKEHGVITYLVINPK--VERKSPQ-HYYRPRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKINTADVPIGQYHFQRRSERTKSQKK--RFEEELNERMIRTFDGINSQKQWLKSEDIQRISLF-FH--NKALEKEYRATTLPAFKYYITCACLIFFCIFIVQILVLPKYACSTSPPF---SHYMITASASWVW----------ILRSSGIIASKPWPRITLTMATTAL--ILIMAVFN---MYFIYSCILGLISCSVF-------LRINYELKMLIMLTAVVLYSVIILQTHASLLD--EYSK---FLYKTEVIERPGVLKDLKTMGSVSLFIFFITLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFL--ARNWKNEDL-YHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGPEYTQEHDRQYMHIGTMVEFAFALVGKLDVINKHSF---NDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCILQTLGYTCSCRGIINVKGKGELKTY 1071 HSP 2 Score: 52.7582 bits (125), Expect = 3.174e-6 Identity = 51/245 (20.82%), Postives = 99/245 (40.41%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQIT------------GSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETYLALRP 3214
E++ E+ L +++P ++ + G ++ + Y + N +++A I F D GE + +L+ + FD + + +IK + DCY SGL S +H + D+ + + V +++G + G V G+IG K YD+W V +A+ M + G++ ++ ++L + E ++K G V TYL + P
Sbjct: 286 EKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQVENTNNFHNLYVQRHTNVSILYADIVGFTR--LASDCSPGE-LVHMLNELFGKFDQIAK---ENECMRIKILGDCYYCVSGLPES----LPNHAKNCVKMGLDMCEAIKKVRDATGV---EISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQERDPYLKEHG-VITYLVINP 516
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Match: ADCY9 (adenylate cyclase 9 [Source:NCBI gene;Acc:100126441]) HSP 1 Score: 226.483 bits (576), Expect = 8.387e-60 Identity = 125/331 (37.76%), Postives = 187/331 (56.50%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD--------------------------LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFK 1402
FS+ V V+L++YT+ HL ++ L + Y ++F + G + +E F + ++ H E L+ + +L ++ G++L I + +R +S FLK+ Q+ ++ ++ I ++MP + + ++ + +F ++ + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR DHA CC+EMGLGM + I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+KT +
Sbjct: 218 FSICVEVLLLLYTVMHLPLYLSACLGVAYSILFET-----FGYHFRDERC---FGPLVGRMAHWE---------LLSKALLHICIHAIGVHLFIMSEVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDDESENSVKRHSASSPKSRKKKSSIQKTPIIFRPFKMQRIEQVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRPDHAYCCIEMGLGMIEAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEKTAR 531 HSP 2 Score: 213.386 bits (542), Expect = 1.082e-55 Identity = 174/518 (33.59%), Postives = 267/518 (51.54%), Query Frame = 2
Query: 1739 FQNPPLNPLTLTFKDTEIESHFQFHVVDQIREI----NINSVKVALFFDAIACQVCSTFVIIS-AFFLIIESGGISKTT-TLVYMSGIPLIMIAGWICLVYKSEIPSEIF---RKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGS-----LYLLLQPTK-----EMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQ-----LFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNAS-----SKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYL 3202
F PP+NPL+L F D E+E+ ++ +++ + S K + D + C F+++S A FL + +S T LV +S L+ + V + ++ R++ I S L R IG + LP +V + Y + Y N YT+ + ++ C F S L+ S+ A AG+ LYL L P K E DI S + + + + + Q F + LL++FL RE E + R+ ++ EA++ + + R A+ L NIIP +V Q+ S SY+K +AGV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN S S+ +R HL L F+ ++++ + +N + N F L+IG+N GP+TAG+IGT+K LYDIWGDTVN+ASRM +T +IQ S+ ++ L + F+YRG V +KGKG ++TYL
Sbjct: 723 FFKPPINPLSLNFLDKELETSYRGSYQEEVLRMAPVKTFASAKFSSLLDVLLCFF--IFILLSVACFLKPGTDPVSPPTLALVLLSVCGLLGFLSLLVSVRMTFYLEDMLLCTRRLLEIISGWLPRHFIGTVLVCLPAAVVFS-YLSSDFYTNIHYTMFLCSALLIPMVQYCNFCQLSSWLR--SSLATIAGATMLTLLYLPLCPEKLRLAPETDIEGNMSTSNSSFEAEDNARTEFPFTLLGQEIAVAYFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQ--------SYSKNHDDAGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPHYSCIEKIKTIGATYMAASGLNPSQCQDSSQPHR--HLQTLFEFAKEMMSVVDDFNNNMLWFN--FKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQASEESYRVLVKMGYDFDYRGTVNVKGKGQMKTYL 1222 HSP 3 Score: 65.4698 bits (158), Expect = 5.845e-10 Identity = 52/235 (22.13%), Postives = 96/235 (40.85%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSY--------------------------AKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE 3151
E+ + E+ +++++P+ + + DD+ + I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ +YL +L E
Sbjct: 320 EKALKERMIHSVMPRIIADDLMKQGDDESENSVKRHSASSPKSRKKKSSIQKTPIIFRPFKMQRIEQVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEETKCEKISTLGDCYYCVAGCPEP----RPDHAYCCIEMGLGMIEAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEKTARYLDDRYLME 540 HSP 4 Score: 54.299 bits (129), Expect = 1.629e-6 Identity = 45/174 (25.86%), Postives = 83/174 (47.70%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDF--GKIMNC-EKIATLGDCYYCVSGC-PVPRSD------HALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFK-LVCHAYTF 1426
Y K + ++FA IV F+ + + K+ +LN+L FD+ +C EKI T+G Y SG P D H E M ++ FN + +R+G + G + A +IG + +D++ + V+IA+ ++++G ++ S+++++ LV Y F
Sbjct: 1031 YSKNHDDAGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPHYSCIEKIKTIGATYMAASGLNPSQCQDSSQPHRHLQTLFEFAKEMMSVVDDFNNNMLWFNFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQASEESYRVLVKMGYDF 1204
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Match: ADCY1 (adenylate cyclase 1 (brain) [Source:NCBI gene;Acc:100492373]) HSP 1 Score: 202.216 bits (513), Expect = 1.353e-52 Identity = 98/247 (39.68%), Postives = 157/247 (63.56%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESI--RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
+ L+ ILF V L+G+++RI ++ AFL+ + +++++ + Q + +++P V E E + +F+ Y ++ NVSILFADIVGFT+++S TA++LV LLN+L+ +FD+ +C +I LGDCYYCVSG P++DHA CCVEMGL M I + + ++NMRVG+H+GRV+ ++G ++++DV+SNDV++AN +E+ G PGKVHI+K T + + Y G
Sbjct: 60 WRTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPG 306 HSP 2 Score: 159.073 bits (401), Expect = 6.574e-39 Identity = 106/273 (38.83%), Postives = 152/273 (55.68%), Query Frame = 2
Query: 2414 LFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKR-GESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGL--NASSKAYRE--DHLYKLMLFS---FDLLNQLAY--YNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
LF L L+ +R+ + +R+ + + +AE D+ R + ++ L+N++P +V S Y ++ GV+FASI NF Y D G L++L+ II FD L+ YK +EKIKT+ YM A GL +KA + HL L FS FD+L+++ Y YNE F L++G N GPV AG+IG +P YDIWG+TVNVASRM ST GKIQV++ VH+ L + ++ F RGKV +KGKG++ TY
Sbjct: 643 LFSCSLALH--SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDL---YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNE--------FVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLTY 902 HSP 3 Score: 72.4034 bits (176), Expect = 3.657e-12 Identity = 56/217 (25.81%), Postives = 102/217 (47.00%), Query Frame = 2
Query: 878 IMPAAVRGEFLES-IRSKDLFNLGYCKQFKNVSILFADIVGFT----AMSSNKTAKQLVYLLNDLYNRFDDFGK---IMNCEKIATLGDCYYCVSGCPVPRS---------DHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKK--------TFKLVCHAYTFIEGEKLMVT 1453
++PA V FL S R+ DL Y + + V ++FA I F + N + + LLN++ FD+ + + EKI T+G Y G VP + H + + M ++ N E +RVG++ G V+A +IG R ++D++ N V++A+ ++S+G GK+ +++ ++ VC ++G+ M+T
Sbjct: 690 LLPAHVAQHFLMSNPRNMDL----YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGL-VPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLT 901 HSP 4 Score: 58.5362 bits (140), Expect = 7.379e-8 Identity = 52/230 (22.61%), Postives = 98/230 (42.61%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETY 3199
E + E+ L +++P+ V ++ F Y + N ++FA I F S + +K+L+ + FD L +IK + DCY SGL + DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++ + L + E + F+K K ++ET+
Sbjct: 108 ENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTS---LASQCTAQELVKLLNELFGKFD---ELATENHCRRIKILGDCYYCVSGLTQP----KTDHAHCCVEMGLDMIDTITSVAEATEV---DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLK-KHNIETF 323
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Match: ADCY1 (adenylate cyclase 1 (brain) [Source:NCBI gene;Acc:100492373]) HSP 1 Score: 202.216 bits (513), Expect = 2.570e-52 Identity = 98/247 (39.68%), Postives = 157/247 (63.56%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESI--RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
+ L+ ILF V L+G+++RI ++ AFL+ + +++++ + Q + +++P V E E + +F+ Y ++ NVSILFADIVGFT+++S TA++LV LLN+L+ +FD+ +C +I LGDCYYCVSG P++DHA CCVEMGL M I + + ++NMRVG+H+GRV+ ++G ++++DV+SNDV++AN +E+ G PGKVHI+K T + + Y G
Sbjct: 194 WRTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPG 440 HSP 2 Score: 159.458 bits (402), Expect = 6.250e-39 Identity = 106/273 (38.83%), Postives = 152/273 (55.68%), Query Frame = 2
Query: 2414 LFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKR-GESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGL--NASSKAYRE--DHLYKLMLFS---FDLLNQLAY--YNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
LF L L+ +R+ + +R+ + + +AE D+ R + ++ L+N++P +V S Y ++ GV+FASI NF Y D G L++L+ II FD L+ YK +EKIKT+ YM A GL +KA + HL L FS FD+L+++ Y YNE F L++G N GPV AG+IG +P YDIWG+TVNVASRM ST GKIQV++ VH+ L + ++ F RGKV +KGKG++ TY
Sbjct: 770 LFSCSLALH--SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDL---YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNE--------FVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLTY 1029 HSP 3 Score: 72.0182 bits (175), Expect = 5.083e-12 Identity = 56/217 (25.81%), Postives = 102/217 (47.00%), Query Frame = 2
Query: 878 IMPAAVRGEFLES-IRSKDLFNLGYCKQFKNVSILFADIVGFT----AMSSNKTAKQLVYLLNDLYNRFDDFGK---IMNCEKIATLGDCYYCVSGCPVPRS---------DHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKK--------TFKLVCHAYTFIEGEKLMVT 1453
++PA V FL S R+ DL Y + + V ++FA I F + N + + LLN++ FD+ + + EKI T+G Y G VP + H + + M ++ N E +RVG++ G V+A +IG R ++D++ N V++A+ ++S+G GK+ +++ ++ VC ++G+ M+T
Sbjct: 817 LLPAHVAQHFLMSNPRNMDL----YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGL-VPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLT 1028 HSP 4 Score: 58.9214 bits (141), Expect = 5.045e-8 Identity = 56/253 (22.13%), Postives = 104/253 (41.11%), Query Frame = 2
Query: 2459 EKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETY 3199
E+ R F +R E + E+ L +++P+ V ++ F Y + N ++FA I F S + +K+L+ + FD L +IK + DCY SGL + DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++ + L + E + F+K K ++ET+
Sbjct: 219 ERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTS---LASQCTAQELVKLLNELFGKFD---ELATENHCRRIKILGDCYYCVSGLTQP----KTDHAHCCVEMGLDMIDTITSVAEATEV---DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLK-KHNIETF 457
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Match: ADCY1 (adenylate cyclase 1 (brain) [Source:NCBI gene;Acc:100492373]) HSP 1 Score: 202.216 bits (513), Expect = 2.839e-52 Identity = 98/247 (39.68%), Postives = 157/247 (63.56%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESI--RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
+ L+ ILF V L+G+++RI ++ AFL+ + +++++ + Q + +++P V E E + +F+ Y ++ NVSILFADIVGFT+++S TA++LV LLN+L+ +FD+ +C +I LGDCYYCVSG P++DHA CCVEMGL M I + + ++NMRVG+H+GRV+ ++G ++++DV+SNDV++AN +E+ G PGKVHI+K T + + Y G
Sbjct: 197 WRTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPG 443 HSP 2 Score: 159.073 bits (401), Expect = 7.472e-39 Identity = 106/273 (38.83%), Postives = 152/273 (55.68%), Query Frame = 2
Query: 2414 LFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKR-GESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGL--NASSKAYRE--DHLYKLMLFS---FDLLNQLAY--YNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
LF L L+ +R+ + +R+ + + +AE D+ R + ++ L+N++P +V S Y ++ GV+FASI NF Y D G L++L+ II FD L+ YK +EKIKT+ YM A GL +KA + HL L FS FD+L+++ Y YNE F L++G N GPV AG+IG +P YDIWG+TVNVASRM ST GKIQV++ VH+ L + ++ F RGKV +KGKG++ TY
Sbjct: 780 LFSCSLALH--SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDL---YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNE--------FVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLTY 1039 HSP 3 Score: 72.0182 bits (175), Expect = 4.971e-12 Identity = 56/217 (25.81%), Postives = 102/217 (47.00%), Query Frame = 2
Query: 878 IMPAAVRGEFLES-IRSKDLFNLGYCKQFKNVSILFADIVGFT----AMSSNKTAKQLVYLLNDLYNRFDDFGK---IMNCEKIATLGDCYYCVSGCPVPRS---------DHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKK--------TFKLVCHAYTFIEGEKLMVT 1453
++PA V FL S R+ DL Y + + V ++FA I F + N + + LLN++ FD+ + + EKI T+G Y G VP + H + + M ++ N E +RVG++ G V+A +IG R ++D++ N V++A+ ++S+G GK+ +++ ++ VC ++G+ M+T
Sbjct: 827 LLPAHVAQHFLMSNPRNMDL----YYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGL-VPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLT 1038 HSP 4 Score: 58.9214 bits (141), Expect = 5.412e-8 Identity = 56/253 (22.13%), Postives = 104/253 (41.11%), Query Frame = 2
Query: 2459 EKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETY 3199
E+ R F +R E + E+ L +++P+ V ++ F Y + N ++FA I F S + +K+L+ + FD L +IK + DCY SGL + DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++ + L + E + F+K K ++ET+
Sbjct: 222 ERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTS---LASQCTAQELVKLLNELFGKFD---ELATENHCRRIKILGDCYYCVSGLTQP----KTDHAHCCVEMGLDMIDTITSVAEATEV---DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLK-KHNIETF 460
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Match: ADCY6 (adenylate cyclase 6 [Source:NCBI gene;Acc:100493933]) HSP 1 Score: 191.815 bits (486), Expect = 4.988e-49 Identity = 121/387 (31.27%), Postives = 202/387 (52.20%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIE---GEKLMVTKE---RQFGLEGFAPTLVPMPTYF--VESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHL-QSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQ 1825
+ L +++F + G+ + ++ AF + QA++ + + Q + +++P V E E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + VNMRVG+HSGRV ++G +++FDV+SNDV++AN +E+ GK G++HI+ T K + Y GE+ KE + F + G + ++ +E R + E +S+ RN+ Q+GID+S+ + + E + + E+ L ++ R++ + + LTF+ ++E + V D+
Sbjct: 283 WKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITSATLKYLNGDYEVEPGNGGERNAYLKEHDIKTFLVTGCSQKRKEEKAMMARLQRARANSNEGLTRVWVPE-RSFPRNK---GSKAFRQMGIDESSKDNRNTQEALNPEDEVDEFLARAIDARSIDQLRKDHVKKFLLTFQTPDLEKKYSKKVDDR 665 HSP 2 Score: 149.828 bits (377), Expect = 6.989e-36 Identity = 99/273 (36.26%), Postives = 145/273 (53.11%), Query Frame = 2
Query: 2390 LKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS-KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
LK+ L L LY ++ E R+ F +A +E + + + L+NI+PK V A + ++ + Y ++ V+FASI NF Y E G L++L+ II FD ++ +K LEKIKT+ YM ASGLN ++ + H+ L ++ L Q+ Y NE + +F +KIG N GPV AG+IG KP YDIWG+TVNVASRM ST IQV+ +++ LA + E RG + +KGKG++ TY
Sbjct: 889 LKFVTPVILTVFVLALYLHAQQVESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAAHFL--AREHRNDELYY-QSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKFKQLEKIKTIGSTYMAASGLNDTTYDKEGKTHITALADYAMKLREQMKYINEHSF---NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMECRGVIKVKGKGEMTTY 1155 HSP 3 Score: 74.7146 bits (182), Expect = 7.867e-13 Identity = 63/272 (23.16%), Postives = 121/272 (44.49%), Query Frame = 2
Query: 2522 RRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKF---SYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSEYQKM*NSLKVA-CNYNQRVTK 3325
+RE + E+ L +++P++V ++ + KK Y + N ++FA I F S + + L+ + FD +L +IK + DCY SGL + R DH + + D++ ++ E V + +++G + G V G++G K +D+W + V +A+ M + AG+I ++ KYL + +V G+ YL +T+++ G ++ E + M L+ A N N+ +T+
Sbjct: 329 QRENQQQERLLLSVLPRHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS---LASQCTAQELVMTLNELFARFD---KLAAENHCLRIKILGDCYYCVSGLPEA----RADHAHCCVEMGVDMIEAISLVRE---VTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITSATLKYLNGDY------EVEPGNGGERNAYLKEHDIKTFLVT--GCSQKRKEEKAMMARLQRARANSNEGLTR 579 HSP 4 Score: 67.781 bits (164), Expect = 1.143e-10 Identity = 59/265 (22.26%), Postives = 114/265 (43.02%), Query Frame = 2
Query: 728 LFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIY---WIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTA----MSSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGCPVPRSD-----HALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHIS--------KKTFKLVCHAYTFIEGEKLMVT 1453
+ V++ LYL +A L QA + + ++Q Y + I+P V FL D Y + + V+++FA I F+ + +N + + LLN++ FD+ K EKI T+G Y SG D H + + + + + N M++G++ G V+A +IG + ++D++ N V++A+ ++S+G P + ++ K +++ C ++G+ M T
Sbjct: 895 VILTVFVLALYLHAQQV--ESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAAHFLAREHRNDEL---YYQSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKFKQLEKIKTIGSTYMAASGLNDTTYDKEGKTHITALADYAMKLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMECRGVIKVKGKGEMTT 1154
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Match: Adcy8 (adenylate cyclase 8 [Source:MGI Symbol;Acc:MGI:1341110]) HSP 1 Score: 313.923 bits (803), Expect = 4.920e-89 Identity = 258/878 (29.38%), Postives = 428/878 (48.75%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIY-EYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q++LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ ++ I LI+ + TT +PLI+ WI Y + IF I + F + + + +P L + +++ ++ + YF T A+++ +F SVLK A +Y LL T ++ Y + D++ + L F L +++ ++ E R+ F +A+ +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 319 VLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINFLGAVLNILWCDFDKSIP--LKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA--IYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFL-----LAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1169 HSP 2 Score: 63.929 bits (154), Expect = 1.132e-9 Identity = 64/277 (23.10%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R DH + + ++ + + KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ K ++ETYL +P E+ +
Sbjct: 335 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RRDHAHCCVEMGLSMIKTIRFVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEESLL 593
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Match: Adcy8 (adenylate cyclase 8 [Source:MGI Symbol;Acc:MGI:1341110]) HSP 1 Score: 308.916 bits (790), Expect = 2.361e-87 Identity = 260/879 (29.58%), Postives = 418/879 (47.55%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFT---ISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q++LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ ++ I LI+ + TT +PLI+ WI Y + IF I + F + + IY L + T +L + + V + +AL++ I+ +SY L +G +L TKE + + L F+ Q + L FL R K EI +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 319 VLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINFLGAV----LNIYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNH-------SGEDFL---GTKE-------------ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKE-----------EI--NEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1139 HSP 2 Score: 63.929 bits (154), Expect = 1.246e-9 Identity = 64/277 (23.10%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R DH + + ++ + + KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ K ++ETYL +P E+ +
Sbjct: 335 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RRDHAHCCVEMGLSMIKTIRFVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEESLL 593
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Match: Adcy9 (adenylate cyclase 9 [Source:MGI Symbol;Acc:MGI:108450]) HSP 1 Score: 231.106 bits (588), Expect = 2.078e-61 Identity = 139/392 (35.46%), Postives = 215/392 (54.85%), Query Frame = 2
Query: 437 SYSVIIGTDADEMME--ARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLS-AVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQ--AKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-------------------------SIRSKDL-FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
S + T AD + FS+ + V+L++YT+ L +++ L +VY ++F + ++R +E+ + AL ++ L+ + +L ++ G++L + + +R +S FLK+ Q+ ++++ A+K ++ I ++MP + + ++ SI+ + F +Q + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR+DHA CC+EMGLGM K I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+ T K + Y +G + + G A L + TY +
Sbjct: 205 SNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFR-----NEDCYPSPGPGAL-------------HWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERM--IHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVI-----ERLGQSVVADQLKGLKTYLI 571 HSP 2 Score: 179.489 bits (454), Expect = 3.962e-45 Identity = 104/268 (38.81%), Postives = 162/268 (60.45%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKH 3241
RE E + R+ ++ EA++ + + R A+ L NIIP +V Q+ S +Y+K + GV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN + + ++HL L F+ +++ + +N + N F L++G+N GP+TAG+IGT+K LYDIWGDTVN+ASRM +T +IQVS+ ++ L+ + F+YRG V +KGKG ++TYL + + ++ +H
Sbjct: 998 REFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQ--------TYSKNHDSGGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFN--FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQH 1254 HSP 3 Score: 65.0846 bits (157), Expect = 5.082e-10 Identity = 62/271 (22.88%), Postives = 113/271 (41.70%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADD-----------------KKSTKFSYA---------KTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSY 3259
E+ + E+ +++++P+ + + D+ KK + A + I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ KYL + E G+V + G L+ +TY+I +S+
Sbjct: 326 EKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEQTKCEKISTLGDCYYCVAGCPEP----RADHAYCCIEMGLGMIKAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME-DGRVIER-LGQSVVADQLKGLKTYLISGQRAKESH 580 HSP 4 Score: 56.6102 bits (135), Expect = 2.196e-7 Identity = 41/170 (24.12%), Postives = 83/170 (48.82%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFD------DFGKIMNCEKIATLGDCYYCVSGCPVPR-------SDHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y K + ++FA IV F+ + + K+ +LN+L FD D+ I EKI T+G Y SG + +H E M +++ FN + +RVG + G + A +IG + +D++ + V+IA+ ++++G ++ +S+++++++
Sbjct: 1050 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSI---EKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 1216
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Match: Adcy9 (adenylate cyclase 9 [Source:MGI Symbol;Acc:MGI:108450]) HSP 1 Score: 231.106 bits (588), Expect = 2.078e-61 Identity = 139/392 (35.46%), Postives = 215/392 (54.85%), Query Frame = 2
Query: 437 SYSVIIGTDADEMME--ARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLS-AVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQ--AKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-------------------------SIRSKDL-FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
S + T AD + FS+ + V+L++YT+ L +++ L +VY ++F + ++R +E+ + AL ++ L+ + +L ++ G++L + + +R +S FLK+ Q+ ++++ A+K ++ I ++MP + + ++ SI+ + F +Q + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR+DHA CC+EMGLGM K I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+ T K + Y +G + + G A L + TY +
Sbjct: 205 SNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFR-----NEDCYPSPGPGAL-------------HWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERM--IHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVI-----ERLGQSVVADQLKGLKTYLI 571 HSP 2 Score: 179.489 bits (454), Expect = 3.962e-45 Identity = 104/268 (38.81%), Postives = 162/268 (60.45%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKH 3241
RE E + R+ ++ EA++ + + R A+ L NIIP +V Q+ S +Y+K + GV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN + + ++HL L F+ +++ + +N + N F L++G+N GP+TAG+IGT+K LYDIWGDTVN+ASRM +T +IQVS+ ++ L+ + F+YRG V +KGKG ++TYL + + ++ +H
Sbjct: 998 REFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQ--------TYSKNHDSGGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFN--FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQH 1254 HSP 3 Score: 65.0846 bits (157), Expect = 5.082e-10 Identity = 62/271 (22.88%), Postives = 113/271 (41.70%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADD-----------------KKSTKFSYA---------KTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSY 3259
E+ + E+ +++++P+ + + D+ KK + A + I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ KYL + E G+V + G L+ +TY+I +S+
Sbjct: 326 EKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEQTKCEKISTLGDCYYCVAGCPEP----RADHAYCCIEMGLGMIKAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME-DGRVIER-LGQSVVADQLKGLKTYLISGQRAKESH 580 HSP 4 Score: 56.6102 bits (135), Expect = 2.196e-7 Identity = 41/170 (24.12%), Postives = 83/170 (48.82%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFD------DFGKIMNCEKIATLGDCYYCVSGCPVPR-------SDHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y K + ++FA IV F+ + + K+ +LN+L FD D+ I EKI T+G Y SG + +H E M +++ FN + +RVG + G + A +IG + +D++ + V+IA+ ++++G ++ +S+++++++
Sbjct: 1050 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSI---EKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 1216
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Match: Adcy9 (adenylate cyclase 9 [Source:MGI Symbol;Acc:MGI:108450]) HSP 1 Score: 218.394 bits (555), Expect = 1.248e-57 Identity = 118/299 (39.46%), Postives = 171/299 (57.19%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLE-------------------------SIRSKDL-FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
++ L+ + +L ++ G++L + + +R +S FLK+ Q+ ++ ++ I ++MP + + ++ SI+ + F +Q + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR+DHA CC+EMGLGM K I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+ T K + Y +G + + G A L + TY +
Sbjct: 41 HWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVI-----ERLGQSVVADQLKGLKTYLI 334 HSP 2 Score: 178.718 bits (452), Expect = 4.869e-45 Identity = 104/269 (38.66%), Postives = 162/269 (60.22%), Query Frame = 2
Query: 2447 TRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKH 3241
RE E + R+ ++ EA++ + + R A+ L NIIP +V Q+ S +Y+K + GV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN + + ++HL L F+ +++ + +N + N F L++G+N GP+TAG+IGT+K LYDIWGDTVN+ASRM +T +IQVS+ ++ L+ + F+YRG V +KGKG ++TYL + + ++ +H
Sbjct: 760 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQ--------TYSKNHDSGGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFN--FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQH 1017 HSP 3 Score: 64.6994 bits (156), Expect = 7.240e-10 Identity = 62/271 (22.88%), Postives = 113/271 (41.70%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADD-----------------KKSTKFSYA---------KTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSY 3259
E+ + E+ +++++P+ + + D+ KK + A + I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ KYL + E G+V + G L+ +TY+I +S+
Sbjct: 89 EKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEQTKCEKISTLGDCYYCVAGCPEP----RADHAYCCIEMGLGMIKAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME-DGRVIER-LGQSVVADQLKGLKTYLISGQRAKESH 343 HSP 4 Score: 56.225 bits (134), Expect = 2.805e-7 Identity = 41/170 (24.12%), Postives = 83/170 (48.82%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFD------DFGKIMNCEKIATLGDCYYCVSGCPVPR-------SDHALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y K + ++FA IV F+ + + K+ +LN+L FD D+ I EKI T+G Y SG + +H E M +++ FN + +RVG + G + A +IG + +D++ + V+IA+ ++++G ++ +S+++++++
Sbjct: 813 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSI---EKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 979
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Match: sp|P40145|ADCY8_HUMAN (Adenylate cyclase type 8 OS=Homo sapiens OX=9606 GN=ADCY8 PE=1 SV=1) HSP 1 Score: 317.005 bits (811), Expect = 3.110e-89 Identity = 266/886 (30.02%), Postives = 427/886 (48.19%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIY-EYS----SCVDFL----VDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q +LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S+ + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ V+ I LI+ + TT +PLI+ WI Y + IF I + F + + + +P L + +++ ++ + YF T A+++ +F SVLK A +Y LL T ++ Y S DFL V + + L F+ Q + L FL R K EI +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 321 VVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINFLGAILNILWCDFDKSIP--LKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA--IYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKE-----------EI--NEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1171 HSP 2 Score: 64.6994 bits (156), Expect = 4.767e-9 Identity = 64/277 (23.10%), Postives = 125/277 (45.13%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R+DH + + ++ + Y KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ K ++ETYL +P ++ +
Sbjct: 337 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RQDHAHCCVEMGLSMIKTIRYVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEDSLL 595
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Match: sp|P40146|ADCY8_RAT (Adenylate cyclase type 8 OS=Rattus norvegicus OX=10116 GN=Adcy8 PE=1 SV=1) HSP 1 Score: 314.694 bits (805), Expect = 1.957e-88 Identity = 260/884 (29.41%), Postives = 429/884 (48.53%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVL------PTLLVHTLYDAEKLYNNYEYTVGYFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIY-EYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q++LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ ++ I LI+ + TT +PLI+ WI Y + IF I + F +G I++L L + +++ ++ + YF T A+++ +F SVLK A +Y LL T ++ Y + D++ + L F L +++ ++ E R+ F +A+ +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 318 VLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINF--------LGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA--IYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFL-----LAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1168 HSP 2 Score: 65.855 bits (159), Expect = 2.319e-9 Identity = 64/277 (23.10%), Postives = 126/277 (45.49%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R+DH + + ++ + + KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L+ + + E GK F++ K ++ETYL +P E+ +
Sbjct: 334 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RQDHAHCCVEMGLSMIKTIRFVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEESLL 592
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Match: sp|P97490|ADCY8_MOUSE (Adenylate cyclase type 8 OS=Mus musculus OX=10090 GN=Adcy8 PE=1 SV=2) HSP 1 Score: 313.923 bits (803), Expect = 3.441e-88 Identity = 258/878 (29.38%), Postives = 428/878 (48.75%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKE-----RQFGLEGF-----APTLVPMPTYFV-ESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIY-EYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE--DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETYLAL 3208
++ Q++LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +V+MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK T + Y EG KE R+ +E + +L+ +P V ES S + S S E + + + + ++++ + N L H+QS PE R+ + + P +L FKD+ +E + + D++ + N + + V LF AI + S+ ++ I LI+ + TT +PLI+ WI Y + IF I + F + + + +P L + +++ ++ + YF T A+++ +F SVLK A +Y LL T ++ Y + D++ + L F L +++ ++ E R+ F +A+ +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL L FS L + N+ + +F L+IG + G V AG+IG KP YDIWG TVN+ASRM ST +G+IQV + + L F F+YRG++++KG +G ++TY L
Sbjct: 319 VLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHG----KERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINL------LPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYS-QMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLAR-NVIIFASILINFLGAVLNILWCDFDKSIP--LKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA--IYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFL-----LAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSF---NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1169 HSP 2 Score: 63.929 bits (154), Expect = 7.921e-9 Identity = 64/277 (23.10%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R DH + + ++ + + KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ K ++ETYL +P E+ +
Sbjct: 335 FISYLSDRAQRQAFLETRRCVEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RRDHAHCCVEMGLSMIKTIRFVRSRT----KHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR-KHNIETYLIKQPEESLL 593
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Match: sp|Q04400|ADCY5_RAT (Adenylate cyclase type 5 OS=Rattus norvegicus OX=10116 GN=Adcy5 PE=1 SV=2) HSP 1 Score: 310.457 bits (794), Expect = 6.003e-87 Identity = 269/901 (29.86%), Postives = 431/901 (47.84%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDE------YFNRKVIDESKSYERNEEKSNESKP--SQIGIDKSALEFK---IRDEKMKNDLELIRHLQSDPE-------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALF--FDAIACQVCSTFVI---ISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPL------SRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFT--ISYSVLKQMSTAACTA-------GSLYLLLQ-----------PT----KEMDIYEYSSCVDFLVDYV----EIQTQ-KLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS--KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
L+ +++F + G+ + ++ AF + + QA++ + Q + +++P V E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + + VNMRVG+HSGRV ++G +++FDV+SNDV++AN +E+ GK G++HI+K T + Y G ER L+ + + T+ + + + E NR+ + S N +P + +G ++ + E K D K KN E ++PE R++ ++ + LTF++ ++E + V D+ + V LF F I S F++ +S F L+ IS V + PL ++ I K+ +F V S + S+ +G ++ + V+ + + + + Y++G + SNC F +YSVL +S AC+ G L L+L P D+ ++ +DF + E T+ LK + L LY ++ E R+ F +A +E + + L+NI+PK V A ++++ + Y ++ V+FASI NF Y E G L++L+ II FD ++ ++ LEKIKT+ YM ASGLN S+ KA + H+ L F+ L++Q+ Y NE + +F +KIG N GPV AG+IG KP YDIWG+TVNVASRM ST +IQV+ +++ LA + + E RG V +KGKG++ TY
Sbjct: 380 LVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG----CGGERNAYLKEHS-----IETFLILRCTQKRKEEKAMIAKMNRQ---RTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQE-----SANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGC-LAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVL--LSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL--ARERRNDELYY-QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGK-THIKALADFAMKLMDQMKYINEHSF---NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1253 HSP 2 Score: 73.559 bits (179), Expect = 1.062e-11 Identity = 60/263 (22.81%), Postives = 114/263 (43.35%), Query Frame = 2
Query: 2459 EKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKF---SYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYK 3238
E + R F +RE ++RE + E+ L +++P++V ++ + K+ Y + N ++FA I F S + + L+ + FD +L +IK + DCY SGL + R DH + + D++ ++ E V + +++G + G V G++G K +D+W + V +A+ M + AG+I ++ YL + +V G+ YL ET++I +
Sbjct: 402 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS---LASQCTAQELVMTLNELFARFD---KLAAENHCLRIKILGDCYYCVSGLPEA----RADHAHCCVEMGMDMIEAISSVRE---VTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDY------EVEPGCGGERNAYLKEHSIETFLILR 645
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Match: sp|Q9DGG6|ADCY9_CHICK (Adenylate cyclase type 9 OS=Gallus gallus OX=9031 GN=ADCY9 PE=1 SV=1) HSP 1 Score: 233.802 bits (595), Expect = 1.926e-61 Identity = 138/372 (37.10%), Postives = 205/372 (55.11%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQ--AKMKMDSAIKVQIYWIEAIMPAAVRGEFLES--------------------------IRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
FS+ V V+L++YT+ HL +++ L + Y ++F TSA R + Y+ L+ + L ++ G++L I + +R +S FLK+ Q+ ++++ A+K ++ I ++MP + + ++ ++ +F +Q + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD + CEKI+TLGDCYYCV+GCP PR+DHA CC+EMGLGM K I F + KE VNMRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVHIS+ T K + Y +G+ VT+ + G A L + TY +
Sbjct: 216 FSMCVEVLLLLYTVMHLPLYLSLFLGLSYSVLFE--------------------TSAFRDESCTLLGGGAVYWELLSKAFLHVCIHAIGIHLFIMSEVRSRSTFLKVGQSIMHGKDLEVEKALKERM--IHSVMPRIIADDLMKQGDDESENSVKRHSTSSPKNRKKKPSIQKTPIIFRPFKMQQIEQVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEDTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGK---VTE--RVGQSAVADQLKGLKTYLI 560 HSP 2 Score: 181.415 bits (459), Expect = 6.666e-45 Identity = 167/580 (28.79%), Postives = 290/580 (50.00%), Query Frame = 2
Query: 1583 YERNEEKSNESKPSQIGIDKSAL-EFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQI-REININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISK----TTTLVYMSGIPLIMIAGWIC--LVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGS-----LYLLLQP-----TKEMDIYE-----YSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKH 3241
YE +EK + + +D+SAL + ++ + K D + ++ D F PP++ L+L F D ++E ++ +++ R + + A F + + +T +I + ++ G ++ +V++ I L +++ I +V+ E +++ + S L R +G + LP L V + + ++ N YT+ A++ C F S ++ S A G+ LY+ L P T +D+ + S C + V+ + +F + LL++FL R E + R+ ++ EA++ + + R + + NIIP +V AD+ K ++ SY+K + GV+FASI NF S +Y E+Y+ G+ +VL+ +I FD LL P Y +EKIKT+ YM ASGLN S + HL L F+ +++ + +N + N F L+IG+N GP+TAG+IGT+K LYDIWGDTVN+ASRM + +IQVS+ ++ L+ + F+YRG V +KGKG ++TYL + + ++ H
Sbjct: 675 YEMLQEKG---RWGGVSLDQSALLPLRFKNIREKTDAHFVDVIKED-SLMKDYFFKPPISKLSLNFLDQDLEMAYRTSYQEEVMRNAPVKTFASATFSSLLDVFLSTTVFLILSVTCFLKHGMVASPPPPAAVVVFVIAILLEVLSLVISVRMVFFLEEVMACTKRLLELISGWLPRHFLGAILVSLPALAVFSHFTSD-FETNIHYTMFMCCAILIAIVQYCNFCQLSSWMR--SLLATVVGAVLLILLYVSLCPDSSVETLHLDLAQNLSSRKSPCNSSMPADVKRPADLIGQEVILAVFLLLLLVWFLNRSFEVSYRLHYHGDVEADLHRTKIQSMRDQPDSCVRNIIPYHV-------ADELKVSQ-SYSKNHDSGGVIFASIVNF-SEFYEENYEGGKECYRVLNELIGDFDELLSKPHYSSIEKIKTIGATYMAASGLNTSQCQDSNHPHGHLQTLFEFAKEMMRVVDDFNNNMLWFN--FKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTIGVECRIQVSEETYRILSKMGYDFDYRGTVNVKGKGQMKTYLYPKCMDNGIVPHH 1236 HSP 3 Score: 68.5514 bits (166), Expect = 3.919e-10 Identity = 64/262 (24.43%), Postives = 111/262 (42.37%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADDK---------------KSTKFSYAKT-----------IVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
E+ + E+ +++++P+ + + DD+ + K S KT I ++FA I G+ + + AL L N + G FD RL EKI T+ DCY +G R DH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ KYL + E GKV + G L+ +TY+I
Sbjct: 315 EKALKERMIHSVMPRIIADDLMKQGDDESENSVKRHSTSSPKNRKKKPSIQKTPIIFRPFKMQQIEQVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFD---RLCEDTKCEKISTLGDCYYCVAGCPEP----RADHAYCCIEMGLGMIKAIEQFCQEK---KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME-DGKVTER-VGQSAVADQLKGLKTYLI 560 HSP 4 Score: 54.299 bits (129), Expect = 7.974e-6 Identity = 39/167 (23.35%), Postives = 80/167 (47.90%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGCPVPRSD-------HALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y K + ++FA IV F+ + + K+ +LN+L FD+ + EKI T+G Y SG + H E M +++ FN + +R+G + G + A +IG + +D++ + V+IA+ +++ G ++ +S++T++++
Sbjct: 1032 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPHYSSIEKIKTIGATYMAASGLNTSQCQDSNHPHGHLQTLFEFAKEMMRVVDDFNNNMLWFNFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTIGVECRIQVSEETYRIL 1198
BLAST of Adenylate cyclase type vs. TrEMBL
Match: A0A2H1CUG7 (Adenylate/guanylate cyclase catalytic domain protein OS=Fasciola hepatica OX=6192 GN=D915_01279 PE=4 SV=1) HSP 1 Score: 632.869 bits (1631), Expect = 0.000e+0 Identity = 394/1061 (37.13%), Postives = 590/1061 (55.61%), Query Frame = 2
Query: 164 LSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIA-FIVFVCFFGLTVNVEKTSTMISLASIMVV-----LCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPN-KYYM-LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFN---LGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEF---DEYFNRKVIDESKSYERNEEKSN---ESKPSQIGIDKSALEF-KIR-----DEKMK-----------NDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAG--WICL-----VYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSA-DDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAY---REDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALR 3211
+ ++S SEYFH + R V+I +I + P+ + + F + + + T + +T L+ + V +C S V++ D+ A ++ +VIL+ + + M ++ +++ + ++ + +E++ T + R++ + K YM I + IL + +L +Y+ +N +RR+ F +L+++ + ++ +A+ ++ WIEAIMP V E+ + R + Y + F VSILFADIVGFT MSSNK+A Q+V LLNDL++RFD+ CEKI TLGDCYYCVSGCP PR +HA CVEMGLGMC++I FN H+EEVNMRVGVH+GRV AAIIG+ RFR+DVYS DV +AN +ESSG+PG+VHIS++T+ LV Y +GE + + +E + G+ G A T V M TYFV+ S+ E+F + + +R ++ N E+ P ++ + K+ +F +IR D+ MK ND+ I+ LQ+DPE+ + +PPLNPL L F + EIE H++ H V I S+K+ + DA+A C+ +I +E ++ T + M I ++++G W + VY ++ S + R+I++I +H R + +S LPT+ A Y E L A + I I S + C S L++ T + + C+ + L+Y +L +++ + R+NE+N R+ FY +REAEI ND ++R + A++FLYNIIPKYV+ ++ S D S FSYA + NAGV+FA + NFFS YYREDYK GE +L +L++IIC FDNLL P K +EKIKT+NDCYM ASGLN + HL LM + + L +N+ IVG+++F +KIGYNFGPVTAGIIGT+KPLYDIWGDTVNVASRMYST G+IQV+++V L F FE+RG VF+KGKG++ T++ R
Sbjct: 42 MRIHSRLMSEYFHDVTLWRTKYDFRLSLTVIICTLIIQIAEAGFLVPVPTSYPVWEICSLFFILLGLYLFTFRPLQYTTYSLLSWCLCVFLFGQICWSRCVLVRRDSRTFANAFAVIVCSVILLPVSRANAFIFSVMSYALEFLVQYHRNMDLDVNQYGTEQYQNTSWIDFDNFRRYTVLTTADFKSYMKQIAEGILHILAFLIAVYVSFWNGLRRRFVFYRLSKSILLRNEVQTALIDKVRWIEAIMPTQVTAEYHQMQRQNEEAGNNMWVYSRAFDPVSILFADIVGFTKMSSNKSAIQIVTLLNDLFSRFDELCLTTKCEKIGTLGDCYYCVSGCPEPRPNHAQLCVEMGLGMCRIIKVFNCDHQEEVNMRVGVHTGRVNAAIIGSRRFRYDVYSYDVIVANLMESSGRPGRVHISERTYNLVKSVYNVSQGEDVQIKREERSGIAGMALTTVTMRTYFVDPRSSTMRRRHEHFGTHLKLRAVGPDRKDQIENTQLETGPDRLEVPKNFTKFGRIRSSTIGDQYMKTIGKWEIIQLENDIRQIQLLQTDPEKQIDLLNSPPLNPLVLNFLNHEIEWHYRTHSVYYKVPTYIESLKMTVLSDAMAL-TCAHIMI--TVICALEHKQSNEWTGIYAMYYISSLLVSGLLWGLILFSSTVYADQLESRLLRQIYLIVAHIYGRECLLALLSSLPTISFVIFRLAITDYQ--EIMDRIVLLQKLAAVCILIHGIPQSSVTWCRLICCIGCS--CLIRSTYRISPGQSRFCIQADDPMIGATMTGLRYLNLLELVFYTVIVNMIGRKNERNCRLCFYVTREAEIVNDLSQRTVQQAQQFLYNIIPKYVYHELQASGHGDLASGSFSYATLVPNAGVMFACVANFFSCYYREDYKGGEGSLTLLNSIICTFDNLLNRPDMKDVEKIKTINDCYMAASGLNQAETRRNFNHRQHLVHLMEYCHLIKESLDQFNDLYIVGSENFVVKIGYNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTGLPGEIQVAEHVITLLEDLFRFEFRGLVFVKGKGEMRTFVCHR 1095
BLAST of Adenylate cyclase type vs. TrEMBL
Match: A0A4E0RZP9 (Adenylate cyclase type OS=Fasciola hepatica OX=6192 GN=D915_000865 PE=4 SV=1) HSP 1 Score: 631.328 bits (1627), Expect = 0.000e+0 Identity = 364/874 (41.65%), Postives = 517/874 (59.15%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLG---YCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEF---DEYFNRKVIDESKSYERNEEKSN---ESKPSQIGIDKSALEF-KIR-----DEKMK-----------NDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAG--WICL-----VYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSA-DDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAY---REDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALR 3211
Y I + IL + +L +Y+ +N +RR+ F +L+++ + ++ +A+ ++ WIEAIMP V E+ + R + Y + F VSILFADIVGFT MSSNK+A Q+V LLNDL++RFD+ CEKI TLGDCYYCVSGCP PR +HA CVEMGLGMC++I FN H+EEVNMRVGVH+GRV AAIIG+ RFR+DVYS DV +AN +ESSG+PG+VHIS++T+ LV Y +GE + + +E + G+ G A T V M TYFV+ S+ E+F + + +R ++ N E+ P ++ + K+ +F +IR D+ MK ND+ I+ LQ+DPE+ + +PPLNPL L F + EIE H++ H V I S+K+ + DA+A C+ +I +E ++ T + M I ++++G W + VY ++ S + R+I++I +H R + +S LPT+ A Y E L A + I I S + C S L++ T + + C+ + L+Y +L +++ + R+NE+N R+ FY +REAEI ND ++R + A++FLYNIIPKYV+ ++ S D S FSYA + NAGV+FA + NFFS YYREDYK GE +L +L++IIC FDNLL P K +EKIKT+NDCYM ASGLN + HL LM + + L +N+ IVG+++F +KIGYNFGPVTAGIIGT+KPLYDIWGDTVNVASRMYST G+IQV+++V L F FE+RG VF+KGKG++ T++ R
Sbjct: 59 YMKQIAEGILHILAFLIAVYVSFWNGLRRRFVFYRLSKSILLRNEVQTALIDKVRWIEAIMPTQVTAEYHQMQRQNEEAGNNMWVYSRAFDPVSILFADIVGFTKMSSNKSAIQIVTLLNDLFSRFDELCLTTKCEKIGTLGDCYYCVSGCPEPRPNHAQLCVEMGLGMCRIIKVFNCDHQEEVNMRVGVHTGRVNAAIIGSRRFRYDVYSYDVIVANLMESSGRPGRVHISERTYNLVKSVYNVSQGEDVQIKREERSGIAGMALTTVTMRTYFVDPRSSTMRRRHEHFGTHLKLRAVGPDRKDQIENTQLETGPDRLEVPKNFTKFGRIRSSTIGDQYMKTIGKWEIIQLENDIRQIQLLQTDPEKQIDLLNSPPLNPLVLNFLNHEIEWHYRTHSVYYKVPTYIESLKMTVLSDAMAL-TCAHIMI--TVICALEHKQSNEWTGIYAMYYISSLLVSGLLWGLILFSSTVYADQLESRLLRQIYLIVAHIYGRECLLALLSSLPTISFVIFRLAITDYQ--EIMDRIVLLQKLAAVCILIHGIPQSSVTWCRLICCIGCS--CLIRSTYRISPGQSRFCIQADDPMIGATMTGLRYLNLLELVFYTVIVNMIGRKNERNCRLCFYVTREAEIVNDLSQRTVQQAQQFLYNIIPKYVYHELQASGHGDLASGSFSYATLVPNAGVMFACVANFFSCYYREDYKGGEGSLTLLNSIICTFDNLLNRPDMKDVEKIKTINDCYMAASGLNQAETRRNFNHRQHLVHLMEYCHLIKESLDQFNDLYIVGSENFVVKIGYNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTGLPGEIQVAEHVITLLEDLFRFEFRGLVFVKGKGEMRTFVCHR 925
BLAST of Adenylate cyclase type vs. TrEMBL
Match: A0A504YCG8 (Adenylate cyclase type OS=Fasciola gigantica OX=46835 GN=FGIG_08069 PE=4 SV=1) HSP 1 Score: 624.009 bits (1608), Expect = 0.000e+0 Identity = 390/1056 (36.93%), Postives = 577/1056 (54.64%), Query Frame = 2
Query: 164 LSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIA-FIVFVCFFGLTVNVEKTSTMISLASIMVV-----LCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLG---YCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEF---DEYFNRKVIDESKSYERNEEKSN---ESKPSQIGIDKSALEF-KIR-----DEKMK-----------NDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYM----SGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSA-DDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAY---REDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALR 3211
+ ++S SEYFH + R V+I +I + P+ + + F++ + + T + +T L+ + V +C S V++ D+ A F+++V ++++ + L FL+ ++ L Y G + + + F + R + D Y I + IL + +L +Y+ +N +RR+ F +L+++ + ++ +A+ ++ WIEAIMP V E+ + R + Y + F VSILFADIVGFT MSSNK+A Q+V LLNDL++RFD+ CEKI TLGDCYYCVSGCP PR +HA CVEMGLGMC++I FN H+EEVNMRVGVH+GRV AAIIG+ RFR+DVYS DV +AN +ESSG+PG+VHIS++T+ LV Y +GE + + +E + G+ G A T V M TYFV+ S+ E+F + + +R ++ N E+ P ++ + K+ +F +IR D+ MK ND+ I+ LQ+DPE+ + + PLNPL L F + EIE H++ H V I S+K+ + DA+A + + +S + + Y+ L + + VY ++ S + R I++I +H R + +S LPT+ A Y E L A + I I S + C S L++ T + + C+ + L+Y +L +++ + R+NE+N R+ FY +REAEI ND ++R + A++FLYNIIPKYV+ ++ S D S FSYA + NAGV+FA + NFFS YYREDYK GE +L +L++IIC FDNLL P K +EKIKT+NDCYM ASGLN + HL LM + + L +N+ IVG+++F +KIGYNFGPVTAGIIGT+KPLYDIWGDTVNVASRMYST G+IQV+++V L F FE+RG VF+KGKG++ T++ R
Sbjct: 42 MRIHSRLMSEYFHDVTLWRTKYDFRLSLTVIICTLIIQIAEAGFLVPVPTSYPVWEICSLFLILMGLYLFTFRPLQYTTYSLLSWCLCVFLFGQICWSRCVLVRRDSRTFANA-FAVIVCSVILLPMSYALEFLVQYHRNMD-----LDVNQY--GTEQYQNTSWIDFDNFRRYTVLTAADF-KTYMKQIAEGILHILAFLIAVYVSFWNGLRRRFVFYRLSKSILLRNEVQTALIDKVRWIEAIMPTQVTAEYHQMQRQNEEAGNNMWVYSRAFDPVSILFADIVGFTKMSSNKSAIQIVTLLNDLFSRFDELCLTTKCEKIGTLGDCYYCVSGCPEPRPNHAQLCVEMGLGMCRIIKVFNCDHQEEVNMRVGVHTGRVNAAIIGSRRFRYDVYSYDVIVANLMESSGRPGRVHISERTYNLVKSVYNVSQGEDVQIKREERSGIAGMALTTVTMRTYFVDPRSSTMRRRHEHFGTHLKLRAVGPDRKDQIENTQLETGPDRLQVPKNVTKFGRIRSSTIGDQYMKTIGKWEMIQLENDIRQIQLLQTDPEKQIDLLNSAPLNPLVLNFLNHEIEWHYRTHSVYYKVPTYIESLKMTVLSDAMALTCAHLMITVICALEHKQSNEWTGIYVMYYVSSLLLSGLLWGLILFSSTVYADQLESRLLRHIYLIVAHIYGRECLLALLSCLPTISFVIFRLAITDYQ--EIMDRIVLLQKLAAVCILIHGIPQSSVTWCRLICCIGCS--CLIRNTYRISPGQSRFCIQADDPMIGATMTGLRYLNLLELVFYTVIVNMIGRKNERNCRLCFYVTREAEIVNDLSQRTVQQAQQFLYNIIPKYVYHELQASGHGDLASGSFSYATLVPNAGVMFACVANFFSCYYREDYKGGEGSLTLLNSIICTFDNLLNRPDMKDVEKIKTINDCYMAASGLNQAETRRNFNHRQHLVHLMEYCHLIKESLDQFNDLYIVGSENFVVKIGYNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTGLPGEIQVAEHVITLLEDLFSFEFRGLVFVKGKGEMRTFVCHR 1084
BLAST of Adenylate cyclase type vs. TrEMBL
Match: A0A504YI32 (Adenylate cyclase 9 OS=Fasciola gigantica OX=46835 GN=FGIG_01544 PE=4 SV=1) HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0 Identity = 377/973 (38.75%), Postives = 556/973 (57.14%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHS---EHDIPNKYYMLIG-------QIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDL-FNLG---YCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNR---------KVIDE------------------SKSYERNE-EKSNESKPSQ----IGIDKSALEFKIRDEKM-----KNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLV-----YKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFA----LISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVD--FLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLN---ASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALR 3211
+S V +++ MY L+ + + +S+++++ +A + S+ + ++L+ + + + N+ Y +G QI+ + V + +YLR +N IRR+ AF KL ++ QA+ + D+A++ Q+ WIEAIMP+ VR E+ +++R K+L + G + K F NVSILFADIVGFT MSSNKTA ++V +LN+L+NRFD+ + CEKI TLGDCYYCVSGCPVPR++HA+CC+EMGLGMC++I FN +E V MR+G+H+GRV AAIIG RFRFDVYS DV IA+ LESSG+PG+VHIS+KTF+LV Y F GE L V KE G+ G + TYFV+ S++ + R ID SKS +R E ++ NE++ Q G A + K D ++ D+ L+ +LQ+DP + F++ P++P L F D E E H++ ++D R ++S KVA D + C + + ++++ L + + ++ + + + IA CL+ Y+ ++ S R+ + I P R I++ PT++ L +L + + VG L A L+ +C+ +S + + A T G + +M + C+ F +D I K F+ +L+ L+ F++RENE+N R+ FY SREAEI DEA + A LYNIIPKYV + D + FSYA +I NAGV FA+I NFFS YYREDYK GE+ALK+L++I+C FD LL LP K +EK+KT+NDCYM+A+GLN + HL LM + ++ L +N I+G F +K+GYN GP+ AG+IGT+KP+YDIWG+TVNVASRMYST GKIQV V + L +F F YR ++F+KGKG ++TYL R
Sbjct: 170 YSAGVVLLICMYAFLPLKLTVCICISVMFVI---TAAGLE-AFHASKRFESSSLNTSLKWIHYDLFRRLRVSNRKYAQVGSLGVVQTQIMSWIPVGIIAIYLRFWNMIRRRMAFFKLGKSVQARQECDAALQGQVRWIEAIMPSVVREEY-QALRKKNLHLSAGMWVFNKTFDNVSILFADIVGFTRMSSNKTAHRVVTMLNNLFNRFDELCEATKCEKIGTLGDCYYCVSGCPVPRANHAICCIEMGLGMCRVIKVFNCDFQESVGMRIGIHTGRVNAAIIGAQRFRFDVYSYDVIIASELESSGRPGRVHISEKTFELVKSVYNFSVGEPLAVRKEEVCGIAGMTLVTTYINTYFVDPRSSQLRKKHERFGSAHVELHSFIDHRSTVRDPSFRMSAYLPAVSKSLDRQESDELNEAEQQQFDLACGSWIRADQRKFNDPQLIMRQFDRDISLVHNLQNDPAHQYRLFRHLPVSPTWLVFYDAETEWHYRTQLLDSTRRTYLDSQKVAPISDVVVCFMITLIILVNCIELQKDHQVLPSNFYVLCVYSLIVYSIAS-ACLIFISTTYEDQLSSVRLRQSYRILIRPWVRELCTAIITLTPTMI---LLLFSRLCTSTAFLVGKRRLVSAACLHCLLIHCV-PLSSAAWSRNICALITFGLITHGTNCMGKMSPHG-DKCLGLTFFID--GIAYGKFCLVFNVELWLCTALVLFVSRENERNCRLCFYVSREAEIAVDEAEQAMNEARDLLYNIIPKYVHDHLKTYCTD---SGFSYAVSIPNAGVAFATISNFFSKYYREDYKGGENALKLLNSIVCMFDELLELPEMKDVEKVKTINDCYMVAAGLNREEVRRNRSSQAHLIALMNYCHLVVESLDEFNNMYIIGTDQFEVKVGYNSGPLIAGVIGTTKPMYDIWGNTVNVASRMYSTGLVGKIQVPQQVAESLQEYFRFVYRDEIFVKGKGMMQTYLCER 1126
BLAST of Adenylate cyclase type vs. TrEMBL
Match: A0A2H1CFY2 (Adenylate cyclase 9 OS=Fasciola hepatica OX=6192 GN=D915_004743 PE=4 SV=1) HSP 1 Score: 622.468 bits (1604), Expect = 0.000e+0 Identity = 380/974 (39.01%), Postives = 556/974 (57.08%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLN-ESEEHNIT-KFT--SALRKVRHSEHDIPNKYYMLIG-------QIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDL-FNLG---YCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNR---------KVIDE------------------SKSYERNE-EKSNESKPSQI----GIDKSALEFKIRDEKM-----KNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLV-----YKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFA----LISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVD--FLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLN---ASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALR 3211
+S V +++ MY L+ + + +S++++L + ES N T K+ R++R + N+ Y +G QI+ + V + +YLR +N IRR+ AF KL ++ QA+ + D+A++ Q+ WIEAIMP+ VR E+ +++R K+L + G + K F NVSILFADIVGFT MSSNKTA ++V +LN+L+NRFD+ + CEKI TLGDCYYCVSGCPVPR++HA+CC+EMGLGMC++I FN +E V MR+G+H+GRV AAIIG RFRFDVYS DV IA+ LESSG+PG+VHIS+KTF+LV Y F GE L V KE G+ G + TYFV+ S++ + R ID SK +R E ++ NE++ Q G A + K+ D ++ D+ L+ +LQ+DP + F++ P++P L F D E E H++ ++D R ++S KVA D + C + + ++++ L + + ++ + + + IA CL+ Y+ ++ S R+ + I P R I++ PT++ L +L + + VG L A L+ +C+ +S + + A T G + +M + C+ F +D ++ K F+ +L+ L+ F++RENE+N R+ FY SREAEI DEA + A LYNIIPKYV + D + FSYA +I NAGV FA+I NFFS YYREDYK GE+ALK+L++I+C FD LL LP K +EK+KT+NDCYM+A+GLN + HL LM + ++ L +N I+G F +K+GYN GP+ AG+IGT+KP+YDIWG+TVNVASRMYST GKIQV V + L +F F YR ++F+KGKG ++TYL R
Sbjct: 170 YSAGVVLLICMYAFLPLKLTVCICISVMFVLTAAGLEAFHASKRFESPSLNTTLKWIHYDLFRRLR-----VSNRKYAQVGSLGVVQTQIMSWIPVGIIAIYLRFWNMIRRRMAFFKLGKSVQARHECDAALQGQVRWIEAIMPSVVREEY-QALRKKNLHLSAGMWVFNKTFDNVSILFADIVGFTRMSSNKTAHRVVTMLNNLFNRFDELCEATKCEKIGTLGDCYYCVSGCPVPRANHAICCIEMGLGMCRVIKVFNCDFQESVGMRIGIHTGRVNAAIIGAQRFRFDVYSYDVIIASELESSGRPGRVHISEKTFELVKSVYNFSVGEPLAVKKEEVCGIAGMTLVTTYINTYFVDPRSSQLRKKHERFGSAHVELHSFIDHRSTVRDPSFRMSAYLPAVSKPLDRQESDELNEAEQQQFDLACGSWIRADQRKLNDPQLIMRQFDRDISLVHNLQNDPAHQYRLFRHLPVSPTWLVFYDAETEWHYRTQLLDSTRRTYLDSQKVAPISDVVVCFMITLIILLNCIQLQKDHHVLPSNFYVLCVYSLVVYSIAS-ACLIFISTTYEDQLSSVRLRQSYRILIRPWVRELCTAIITLTPTMI---LLLFSRLCTSTAFLVGKRRLVSAACLHCLLIHCV-PLSSAAWSRNICALITFGLITHGTNCMGKMSPHG-DKCLGLTFFID--DVAYGKFCLVFNVELWLCTALVLFVSRENERNCRLCFYVSREAEIAVDEAEQAMNEARDLLYNIIPKYVHDHLKTYCTD---SGFSYAVSIPNAGVAFATISNFFSKYYREDYKGGENALKLLNSIVCMFDELLELPEMKDVEKVKTINDCYMVAAGLNREEVRRNRSSQAHLIALMNYCHLVVESLDEFNNMYIIGTDQFEVKVGYNSGPLIAGVIGTTKPMYDIWGNTVNVASRMYSTGLVGKIQVPQQVAESLQEYFRFIYRDEIFVKGKGMMQTYLCER 1126
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Match: adcy3b (adenylate cyclase type 3-like [Source:NCBI gene;Acc:103034748]) HSP 1 Score: 319.316 bits (817), Expect = 9.309e-92 Identity = 259/889 (29.13%), Postives = 401/889 (45.11%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSK-------DLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIE---GEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVI-------------DESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYE------YTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTA----------GSLYLLLQPTKEMDIYEYSSCVDF--LVDYVEIQTQ--KLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGE-SALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGL------NASSKAYRED--------HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
L+ ++L+F + G+ + ++AFL+ Q+ + + +D Q + +I+P + E L+ ++ + FN Y + +NVSILFADIVGFT +SS +A++LV LLN+L+ RFD + +I LGDCYYC+ G P R DHA C + MGL M K I K EV+MRVGVH+G V+ ++G R++FDV+S DV++AN +ES G PG+VHIS+ T + + + E GE+ E+ G++ + LVP T + + N V+ + S RN E+ +Q S + DE N L + + E T + + L+L F D E+E+ + Q A +C C + SA ++I+ TL + LI+ + +++ +F + V FS + R + + V + + + + + + FTL YS + +S A T + L+ T +DIY + D L+ Y+E + KY + + + + LY+ R E+ R F E + + R E + N++P++V GS KK + Y+++ GV+FASI NF Y E G L++L+ II FD+LL + + KIKT+ YM ASG+ N S ED HL L F+ + L N+++ F L+IG N G V AG+IG KP YDIWG+TVNVASRM ST G IQV + +K L + F F RG +F+KGKG++ TY
Sbjct: 207 LVANMMLYFGAMVVGVMSYFMADRKYRTAFLEAKQSLEVSLTLDEQSTQQEELLLSILPKHIADEMLQGMKKEANQKSEAQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAQYHQLRIKILGDCYYCICGLPDYRPDHAACSIMMGLAMVKAISYVREKTKTEVDMRVGVHTGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGRVHISQSTMECLSGEFELEEGNGGERCDYLMEK--GIDTYL-VLVPTETSTEGGLTNGVNGVTNGTVVCRNSPTLIATTQTNGSVRSVRNITADTETADTQRLQVSSRADGGTEDEHDLNTLLNKTLVDREMEET---LEEKRTSVLSLRFVDPELETRYSLEKERQTGA-------------AFSCS-CVVLIFTSAMEMLIDPQLTVNYVTLAIGEVLLLILTICSLAVIFP-----RLFSEKLVSFSLWIDRTRWARNTWAMAAIFVLAMAEVADMLSCMQPPLLLLNSTAGFTLETLGDGGCAENPKHYSYIAVLSLVATTMLVQVSHLVKLALMLLVTVATSAVDIYSWRDIYDIYDLIRYLEYRNSVVPTKYLMTVMIIVMMIGLYYFARHVERQARKLFLWKIEVHDQKERVYEMRTYNEALVTNMLPEHVARHFLGS---KKRDEELYSQSYDEIGVMFASIPNFSDFYTEEGINNGGIECLRILNEIISDFDSLLDRTQFLCITKIKTIGSTYMAASGVTPESNTNGYSDRKEEDQCFLERWQHLADLADFALAMKVTLNNLNKQSF---NSFMLRIGLNMGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYKILREYGFRFVRRGPIFVKGKGELLTY 1064 HSP 2 Score: 68.5514 bits (166), Expect = 3.554e-11 Identity = 62/278 (22.30%), Postives = 120/278 (43.17%), Query Frame = 2
Query: 659 LRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGF----TAMSSNKTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSG------------------CPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVN---MRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
+R + + +P KY M + I++ +Y + R RK K+ + Q K ++ + ++P V FL S + + Y + + + ++FA I F T N + + +LN++ + FD D + + KI T+G Y SG C + R H + L M + N L+K+ N +R+G++ G V+A +IG + +D++ N V++A+ +ES+G G + + + +K++
Sbjct: 773 IRYLEYRNSVVPTKYLMTVMIIVMMIGLYY---FARHVERQARKLFLWKIEVHDQ-KERVYEMRTYNEALVTNMLPEHVARHFLGSKKRDEEL---YSQSYDEIGVMFASIPNFSDFYTEEGINNGGIECLRILNEIISDFDSLLDRTQFLCITKIKTIGSTYMAASGVTPESNTNGYSDRKEEDQCFLERWQHLADLADFALAM---KVTLNNLNKQSFNSFMLRIGLNMGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYKIL 1040
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Match: adcy5 (adenylate cyclase 5 [Source:NCBI gene;Acc:103026414]) HSP 1 Score: 306.22 bits (783), Expect = 9.402e-87 Identity = 259/877 (29.53%), Postives = 423/877 (48.23%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNES----KP--SQIGIDKSALEFK---IRDEKMKNDLELIRHLQSDPE-----------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGW-ICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLL--VHTLYDAEKLYNNYEYTVGYFT---LTFFALISNCIF--TISYSVLKQMSTAACT-----AGSLYLLLQPTKEMDIYEYSSCVDFLV--DYVEIQTQK--LKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS--KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
+ ++ +++F + G+ ++ AF + + QA++ + Q + +++P V E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + VNMRVG+HSGRV ++G +++FDV+SNDV++AN +E+ GK G++HI+K T + Y G ER L+ + TY + S + E + +I + N N S +P + +G ++ + E K D K KN E +L + E R++ ++ + LTF++ ++E + V + + V LF + TF++ F + + + + S + ++ + I LV+ S F IF + L R +G ++ P+ + H A + ++ Y T F S+C+ ++ SV QMS+ LY+L+ E+ +++ D LV + + + + LK + L LY ++ E R+ F +A +E + + L+NI+PK V A ++++ + Y ++ V+FASI NF Y E G L++L+ II FD ++ ++ LEKIKT+ YM ASGLN S+ KA R H+ L ++ L++Q+ Y NE + +F +KIG N GPV AG+IG KP YDIWG+TVNVASRM ST +IQV+ +++ L ++ + E RG V +KGKG++ TY
Sbjct: 324 WRQIVSNVLIFSCTNIVGVCTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYDVEPGS----GGERNVYLKKHN-----IETYLIVGCSQKRKE--EKAMIAKMNRQRTNSVTHNSSHWTDRPFYNHLGSNQVSKEMKRMGFEDPKDKNTQE---NLNPEDEVDEFLGRAIDARSIDRLRSEHVKKFLLTFREPDLEKKYSKQVDSRFGAYVACASLVFLFISPL------TFILFGQLFPV----PLQNLSKRIVQSRLNSALVGVFTIVLVFLSA-----FINIFTCSTDDLKR-CLGREFNITPSSVNACHVRSSAFNYSLWSQDSLCYSTAPACNFPEYFSSCVLLSLLACSVFLQMSSIGKLFLMLFIEILYVLIIEVPEVSLFDNG---DLLVIANAICVTDSRVPLKIMTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL--ARERRNDELYY-QSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAASGLNDSTYDKAGR-SHIRALADYAMRLMDQMKYINEHSF---NNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLNSYNYSLECRGVVKVKGKGEMMTY 1160
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Match: adcy2a (adenylate cyclase type 2-like [Source:NCBI gene;Acc:103036916]) HSP 1 Score: 295.049 bits (754), Expect = 2.801e-83 Identity = 257/904 (28.43%), Postives = 422/904 (46.68%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV----RGEFLESIRSKDL--------FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG---EKLMVTKERQF--------GLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKS------YERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESG-GISKTTTLVYMSGIPLIMIAGWICLVYKSEIPS--EIFRKIFVIFSHPLSRLSIGIYI-----------------SVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFAL---ISNCIFT-ISYSV-------LKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQT----QKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY-KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED-----HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHK-YLATHFLFEYRGKVFMKGKGDVETY 3199
+ ++ II+F + G Y + + K + ++ +K++ + Q + +++PA + + E ++ ++ + F+ Y ++ NVSIL+ADIVGFT ++S+ + +LV++LN+L+ +FD K C +I LGDCYYCVSG P +HA CV+MGL MC+ I ++NMRVGVHSG V+ +IG ++++DV+S+DV++AN +E+ G PG+VHI+ T + + AY +G E+ KE E +P P + +E R + + + R+ + K + + F+ R E+ K+ + R + ER ++ F L +D + S F FH +E ++ ++ AC + I+ L + GIS + + +S I LI G K+ S I R +I + P RL++ + +++P++ V+ + E L V + + F L I +CI IS SV LK + G ++L+ + + EYS FL ++ + LK S LF + L L R+NE R+ F + + +E + L N++P +V A + K+ Y ++ V+FASI +F Y D K G L++L+ II FD LL P + G+EKIKT+ YM A+GLNA+ + +E H+ ++ F+F L+ +L N+ + F L++G N GPV AG+IG KP YDIWG+TVNVASRM ST GKIQV++ + LA + RG + +KGKG+++TY
Sbjct: 190 WDQILANIIIFICGNMAGAYHKHLMELALKQTYHDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPNFGQVENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATSVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGYGQERDAYLKEHGVVTYLVINPKAERRSPQHHYRPRHTMEGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKINTADVPLGQYHFRRRSERTKSQKK--RFEEELNERMIRTFDGINSQKQWLKSEDIQRISMF-FHNKALEKEYRATTLPAFKYYITCACLIFFCIFIVQILVLPKTAVLGISFGMSFLILSMILLICFIGHFLHCSKTASASWLWILRSSSIIANKPWPRLTLTMATTTLILVMAVFNMFFLEDNLIPSVPVYNTSN-ETLLQPDGRPVAFLEKSSFYLPYFIYSCILGLISCSVFLRINYELKMLIMLTAVVGYNIIILETHASL-LDEYSK---FLYKTEVLERPGVLKDLKTMGSVSLFIFFVTLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFL--ARNWKNEDL-YHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPEHAQEHDRQYMHIGTMVEFAFALVGKLDVINKHSF---NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSRILLALGYTCSCRGIINVKGKGELKTY 1079 HSP 2 Score: 54.299 bits (129), Expect = 8.438e-7 Identity = 57/273 (20.88%), Postives = 110/273 (40.29%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQIT------------GSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETYLALRP-YETYMIYKHGKAKSYSEYQKM*NSLKV 3295
E++ E+ L +++P ++ + G ++ + Y + N +++A I F D GE + +L+ + FD + + +IK + DCY SGL S +H + D+ + + V +++G + G V G+IG K YD+W V +A+ M + G++ ++ ++L + E ++K G V TYL + P E H + + E KM S+++
Sbjct: 238 EKRQQERLLLSLLPAHIARVMKAEIIQRLQGPNFGQVENTNNFHNLYVQRHTNVSILYADIVGFTR--LASDCSPGE-LVHMLNELFGKFDQIAK---ENECMRIKILGDCYYCVSGLPESLP----NHAKNCVKMGLDMCEAIKKVRDATSVD---INMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGYGQERDAYLKEHG-VVTYLVINPKAERRSPQHHYRPRHTMEGAKMRASVRM 496
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Match: adcy9 (adenylate cyclase 9 [Source:NCBI gene;Acc:103022434]) HSP 1 Score: 223.016 bits (567), Expect = 4.866e-59 Identity = 162/514 (31.52%), Postives = 255/514 (49.61%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLES----------------------------IRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKL----MVTKERQFGLE----------------------GFAPTLVPMPT-YFVESYSTEFDEYFNRKVIDESKSYER--------NEEKSNESKPS----------QIGIDKSAL-EFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQ 1807
FSL + V+L++Y++ HLR ++LL I+Y ++F + + L + EE + S+L + +++G+++L ++ G++L I + +R +S FLK+ Q ++ ++ I ++MP V E ++ R + +F K+ + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD ++ CEKI+TLGDCYYCV+GCP PR DHA CCVEMGLGM + I F + +E V+MRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVH+S+ T + Y +G + E+ GL+ F+ TL P P + E E+ + +S + EE S+ S +G+D+SAL + + + K+D+ + ++ D F PP+N L+L F + +ES ++
Sbjct: 233 FSLCMEVLLLLYSMLHLRLYASVLLGILYSVLFETLGWFHLTHVDGEE----EANSSLMQ-------------LVLGKVLLHLCAHVIGIHLFIMSEVRSRSTFLKVGQAIMHGKDLEVEKALKERMIHSVMPQVVADELMKQGDDESENSGKRPTSSSSPKSNKRKKTSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTRCEKISTLGDCYYCVAGCPEPREDHAYCCVEMGLGMIQAIEQFCQETRETVDMRVGVHTGTVLCGILGIKRFKFDVWSNDVNLANLMEQLGMAGKVHLSEATASFLDDRYVREDGRVMERAGQSVTEQLKGLKTYLISGKKVSSQCSCSQNNLGRDFSETLNPSPRLHTSELTHPTVAEHIKVGLFPAGRSPKAVNGLLSPLCEEGVRASQTSLCEMLQKERRGMGMDRSALIPLRTKGFREKSDVHFVDVIKED-SLMKDYFFKPPINKLSLNFLEKSLESAYR 728 HSP 2 Score: 185.267 bits (469), Expect = 4.152e-47 Identity = 110/255 (43.14%), Postives = 160/255 (62.75%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYL 3202
RE E + R+ ++ + EA+ + + R A+ L NIIP +V A+ K T+ SY+K N GV+FASI NF S +Y E Y+ G+ +VL+ +I FD LLR P + +EKIKT+ YM ASGLN + + HL L F+ ++++ + +N+ N++G + F L+IG+N GP+TAG+IGT+K LYDIWGDTVN+ASRM ST +IQVS+ H L+ ++ F+YRG V +KGKG + TYL
Sbjct: 925 REFEVSYRLHYHGNVEADKHRIKIQNMRDQADWLLRNIIPIHV-------AEQLKVTQ-SYSKNHDNVGVIFASIVNF-SEFYEESYEGGKECYRVLNELIGDFDELLRKPTFSNVEKIKTIGATYMAASGLNGRQCREQTHPHAHLCALFEFALEMMHVVDDFNK-NMLGFQ-FKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEESHCILSGMNYAFDYRGTVNVKGKGQMRTYL 1168 HSP 3 Score: 71.2478 bits (173), Expect = 5.410e-12 Identity = 66/284 (23.24%), Postives = 122/284 (42.96%), Query Frame = 2
Query: 2456 NEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADD------KKSTKFSYAKT-------IVNAGVVF--------ASIGNFFS---GYYREDYKRGESALKVLHNIICG-FDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
+E R F +A + + E+ + E+ +++++P+ V ++ DD K+ T S K+ I ++F + F+ G+ + + AL L N + G FD L L EKI T+ DCY +G REDH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ +L ++ E G+V + V L+ +TY+I
Sbjct: 311 SEVRSRSTFLKVGQAIMHGKDLEVEKALKERMIHSVMPQVVADELMKQGDDESENSGKRPTSSSSPKSNKRKKTSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEL---TRCEKISTLGDCYYCVAGCPEP----REDHAYCCVEMGLGMIQAIEQFCQET---RETVDMRVGVHTGTVLCGILGIKRFKFDVWSNDVNLANLMEQLGMAGKVHLSEATASFLDDRYVRE-DGRVMERAGQSVTE--QLKGLKTYLI 581 HSP 4 Score: 70.4774 bits (171), Expect = 1.075e-11 Identity = 47/163 (28.83%), Postives = 83/163 (50.92%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDFGK---IMNCEKIATLGDCYYCVSG-----CPVPRSDHALCCV--EMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT 1396
Y K NV ++FA IV F+ S + K+ +LN+L FD+ + N EKI T+G Y SG C HA C E L M ++ FN+ + + +R+G + G + A +IG + +D++ + V+IA+ ++S+G ++ +S+++
Sbjct: 977 YSKNHDNVGVIFASIVNFSEFYEESYEGGKECYRVLNELIGDFDELLRKPTFSNVEKIKTIGATYMAASGLNGRQCREQTHPHAHLCALFEFALEMMHVVDDFNKNMLGFQFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEES 1139
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Match: adcy9 (adenylate cyclase 9 [Source:NCBI gene;Acc:103022434]) HSP 1 Score: 216.853 bits (551), Expect = 6.334e-57 Identity = 130/358 (36.31%), Postives = 196/358 (54.75%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLES------------------------------------------IRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
FSL + V+L++Y++ HLR ++LL I+Y ++F + + L + EE + S+L + +++G+++L ++ G++L I + +R +S FLK+ Q ++ ++ I ++MP V E ++ R + +F K+ + VSILFADIVGFT MS+NK+A LV LLNDL+ RFD ++ CEKI+TLGDCYYCV+GCP PR DHA CCVEMGLGM + I F + +E V+MRVGVH+G V+ I+G RF+FDV+SNDV++AN +E G GKVH+S+ T + Y +G
Sbjct: 233 FSLCMEVLLLLYSMLHLRLYASVLLGILYSVLFETLGWFHLTHVDGEE----EANSSLMQ-------------LVLGKVLLHLCAHVIGIHLFIMSEVRSRSTFLKVGQAIMHGKDLEVEKALKERMIHSVMPQVVADELMKQGDDESENSGKRYSATGTGQASASTGPTSSSSPKSNKRKKTSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTRCEKISTLGDCYYCVAGCPEPREDHAYCCVEMGLGMIQAIEQFCQETRETVDMRVGVHTGTVLCGILGIKRFKFDVWSNDVNLANLMEQLGMAGKVHLSEATASFLDDRYVREDG 573 HSP 2 Score: 184.882 bits (468), Expect = 6.013e-47 Identity = 110/255 (43.14%), Postives = 160/255 (62.75%), Query Frame = 2
Query: 2450 RENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS---KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYL 3202
RE E + R+ ++ + EA+ + + R A+ L NIIP +V A+ K T+ SY+K N GV+FASI NF S +Y E Y+ G+ +VL+ +I FD LLR P + +EKIKT+ YM ASGLN + + HL L F+ ++++ + +N+ N++G + F L+IG+N GP+TAG+IGT+K LYDIWGDTVN+ASRM ST +IQVS+ H L+ ++ F+YRG V +KGKG + TYL
Sbjct: 990 REFEVSYRLHYHGNVEADKHRIKIQNMRDQADWLLRNIIPIHV-------AEQLKVTQ-SYSKNHDNVGVIFASIVNF-SEFYEESYEGGKECYRVLNELIGDFDELLRKPTFSNVEKIKTIGATYMAASGLNGRQCREQTHPHAHLCALFEFALEMMHVVDDFNK-NMLGFQ-FKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEESHCILSGMNYAFDYRGTVNVKGKGQMRTYL 1233 HSP 3 Score: 70.4774 bits (171), Expect = 9.273e-12 Identity = 47/163 (28.83%), Postives = 83/163 (50.92%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDDFGK---IMNCEKIATLGDCYYCVSG-----CPVPRSDHALCCV--EMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT 1396
Y K NV ++FA IV F+ S + K+ +LN+L FD+ + N EKI T+G Y SG C HA C E L M ++ FN+ + + +R+G + G + A +IG + +D++ + V+IA+ ++S+G ++ +S+++
Sbjct: 1042 YSKNHDNVGVIFASIVNFSEFYEESYEGGKECYRVLNELIGDFDELLRKPTFSNVEKIKTIGATYMAASGLNGRQCREQTHPHAHLCALFEFALEMMHVVDDFNKNMLGFQFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEES 1204 HSP 4 Score: 65.0846 bits (157), Expect = 4.595e-10 Identity = 45/174 (25.86%), Postives = 82/174 (47.13%), Query Frame = 2
Query: 2711 KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
K + + +L+++ FD L L EKI T+ DCY +G REDH Y + ++ + + +E + +++G + G V GI+G + +D+W + VN+A+ M AGK+ +S+ +L ++ E G+V + V L+ +TY+I
Sbjct: 435 KSAHALVGLLNDLFGRFDRLCEL---TRCEKISTLGDCYYCVAGCPEP----REDHAYCCVEMGLGMIQAIEQFCQET---RETVDMRVGVHTGTVLCGILGIKRFKFDVWSNDVNLANLMEQLGMAGKVHLSEATASFLDDRYVRE-DGRVMERAGQSVTE--QLKGLKTYLI 595
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Match: adcy9 (adenylate cyclase 9 [Source:ZFIN;Acc:ZDB-GENE-050208-455]) HSP 1 Score: 223.787 bits (569), Expect = 5.158e-60 Identity = 131/346 (37.86%), Postives = 193/346 (55.78%), Query Frame = 2
Query: 488 FSLMVAVILMMYTLFHLRFLITMLLSIVYILIF-LSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQN--AQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLE--------------------------SIRSKDL-FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
F++ V V+L++YT L LL + Y ++F + + GL + ++ H+E ++G+ L ++ G+++ I + +R +S FLK+ Q+ +++++ A+K ++ I A+MP + E L SI + L F K+ VS+LFADIVGFT MS+NK+A LV LLNDL+ RFD ++ CEKI+TLGDCYYCV+GCP PR+DHA CCVEMGLGM I F R ++E V+MRVGVH+G V+ I+G RF+FDV SNDV++AN +E G GKVH+S+ T + YT +G
Sbjct: 146 FAVCVEVLLLLYTAMPLPLYACALLGLSYSVLFEVVGQLWSTGLL------LPNVSAGWLSRAHTE----GLAATVVGKAFLHLCIHAIGIHIFIMSQVRSRSTFLKVGQSIIHGKELEVEKALKEKM--IHAVMPRMIADELLRQQGDDDSEASAPTTASNPGPRKKKKGSIPREQLPFRPFTMKRMSEVSVLFADIVGFTKMSANKSAATLVRLLNDLFGRFDKLCEVTGCEKISTLGDCYYCVAGCPEPRTDHAACCVEMGLGMIAAIEQFCRDNRETVDMRVGVHTGTVLCGILGMKRFKFDVLSNDVNLANMMEQLGVAGKVHVSEATALCLDERYTMEDG 479 HSP 2 Score: 188.348 bits (477), Expect = 9.095e-49 Identity = 106/259 (40.93%), Postives = 157/259 (60.62%), Query Frame = 2
Query: 2435 LYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSF--DLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVS-DYVHKYLATHFLFEYRGKVFMKGKGDVETYL 3202
++FL RE E R+ ++ + EAE+ + + + A+ L+NIIP +V D+ + Y+K + GV+FASI NF S +Y E+Y+ G+ +VLH ++ D LL Y G+EKIKT+ YM ASGLN + H + LF F D+++ + +N++ + N F L+IG+N GP+TAG+IGT+KPLYDIWGDTVN+ASRM ST ++QVS + H + F+YRG V +KGKG ++TYL
Sbjct: 927 IWFLNREFEVAYRLNYHGNVEAELHQRKIQHMKNQADLLLHNIIPGHV--------ADQLKVQPHYSKNHEDVGVIFASIVNF-SEFYEENYEGGKECYRVLHELMSDLDQLLARDHYGGIEKIKTIGATYMAASGLNVPEPRAGDAHAHLRTLFEFARDMMSIVEDFNKDMLWFN--FRLRIGFNHGPLTAGVIGTTKPLYDIWGDTVNIASRMDSTGVDCRVQVSQESYHVLCDMGYQFDYRGTVNVKGKGQMKTYL 1174 HSP 3 Score: 64.3142 bits (155), Expect = 1.476e-10 Identity = 52/198 (26.26%), Postives = 96/198 (48.48%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAM--SSNKTAKQLVYLLNDLYNRFDD------FGKIMNCEKIATLGDCYYCVSG--CPVPRSD----HALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCH-AYTFIEGEKLMVTKERQFGLEGFAPT 1492
Y K ++V ++FA IV F+ + + K+ +L++L + D +G I EKI T+G Y SG P PR+ H E M ++ FN+ + +R+G + G + A +IG + +D++ + V+IA+ ++S+G +V +S++++ ++C Y F + V + Q F PT
Sbjct: 984 YSKNHEDVGVIFASIVNFSEFYEENYEGGKECYRVLHELMSDLDQLLARDHYGGI---EKIKTIGATYMAASGLNVPEPRAGDAHAHLRTLFEFARDMMSIVEDFNKDMLWFNFRLRIGFNHGPLTAGVIGTTKPLYDIWGDTVNIASRMDSTGVDCRVQVSQESYHVLCDMGYQFDYRGTVNVKGKGQMKTYLFPPT 1178 HSP 4 Score: 57.3806 bits (137), Expect = 2.148e-8 Identity = 64/280 (22.86%), Postives = 112/280 (40.00%), Query Frame = 2
Query: 2471 RIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAG----------------------------VVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMK-GKGDV--ETYLALRPY 3217
R F ++ I E E+ + EK ++ ++P+ + ++ D S + S T N G V+FA I F K + +++L+++ FD L + G EKI T+ DCY +G R DH + ++ + + +N + +++G + G V GI+G + +D+ + VN+A+ M AGK+ VS+ L + E G++F + G V E ALR Y
Sbjct: 237 RSTFLKVGQSIIHGKELEVEKALKEKMIHAVMPRMIADELLRQQGDDDS-EASAPTTASNPGPRKKKKGSIPREQLPFRPFTMKRMSEVSVLFADIVGFTK---MSANKSAATLVRLLNDLFGRFDKLCEV---TGCEKISTLGDCYYCVAGCPEP----RTDHAACCVEMGLGMIAAIEQFCRDN---RETVDMRVGVHTGTVLCGILGMKRFKFDVLSNDVNLANMMEQLGVAGKVHVSEATALCLDERYTME-DGRLFERIGPNAVLAEQLKALRWY 501
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008766.1 (pep scaffold:Pmarinus_7.0:GL476654:390837:418056:1 gene:ENSPMAG00000007932.1 transcript:ENSPMAT00000008766.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 186.808 bits (473), Expect = 4.956e-53 Identity = 91/234 (38.89%), Postives = 144/234 (61.54%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKD---LFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFK 1402
L+ ++F + G+ + ++ AF + + +A+++ + Q + +++P V E I +K +F+ Y ++ NVSILFADI GFT+++S TA++LV LN+L+ RFD +C +I LGDCYYCVSG P R+DHA CCVEMG+ M + I + VNMRVG+HSGRV ++G ++++FDV+SNDV++AN +E+ GK G++HI+K T +
Sbjct: 12 LVANALVFVCTNMAGVCTHYPTEVAQRQAFHETRECIKARLRTQKENQQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLIKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLR 245 HSP 2 Score: 76.6406 bits (187), Expect = 2.975e-15 Identity = 59/257 (22.96%), Postives = 112/257 (43.58%), Query Frame = 2
Query: 2471 RIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKF---SYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMI 3232
R F+ +RE ++E + E+ L +++P++V ++ + KK Y + N ++FA I F S + + L+ + FD +L +IK + DCY SGL + R DH + + D++ ++ E V + +++G + G V G++G K +D+W + V +A+ M + AG+I ++ +YL + +V G+ YL ET++I
Sbjct: 38 RQAFHETRECIKARLRTQKENQQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTS---LASQCTAQELVMTLNELFARFD---KLAAENHCLRIKILGDCYYCVSGLPEA----RADHAHCCVEMGVDMIEAISLVRE---VTGVNVNMRVGIHSGRVHCGVLGLIKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLRYLNGDY------EVEAGHGGERNAYLKTHSIETFLI 275
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Match: ADCY1 (adenylate cyclase 1 [Source:HGNC Symbol;Acc:HGNC:232]) HSP 1 Score: 199.904 bits (507), Expect = 5.112e-53 Identity = 96/247 (38.87%), Postives = 155/247 (62.75%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESI--RSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
+ L+ + LF V L+G ++R+ ++ AFL+ + +++++ + Q + +++P V E E + +F+ Y ++ NVSILFADIVGFT+++S TA++LV LLN+L+ +FD+ +C +I LGDCYYCVSG P++DHA CCVEMGL M I + + ++NMRVG+H+GRV+ ++G ++++DV+SNDV++AN +E+ G PGKVHI+K T + Y G
Sbjct: 13 WLKLLANVSLFVSVNLSGAFIRVLTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRHVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKSTLDCLNGDYEVEPG 259 HSP 2 Score: 149.443 bits (376), Expect = 6.929e-37 Identity = 98/265 (36.98%), Postives = 147/265 (55.47%), Query Frame = 2
Query: 2447 TRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYV---FFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKR-GESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE----DHLYKLMLFS---FDLLNQLAY--YNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYL-ATHFLFEYRGKVFMKGKGDVETY 3199
+R+ + +R+ + + +AE + R + ++ L+N++P +V F Q D Y ++ GV+FASI NF Y D G L++L+ II FD LL +K +EKIKT+ YM A GL +S + HL + F+ FD+++++ Y YN+ F L++G + GPV AG+IG +P YDIWG+TVNVASRM ST GKIQVS+ V+K L +++ F RGKV +KGKG++ TY
Sbjct: 604 SRQLDLKLRLDYLWASQAEDERGDMERVKNDNKRILFNLLPAHVAQHFLQSNPRNMDL------YYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELLDKECFKDIEKIKTIGSTYMAAVGLVPTSGTKAKCSIISHLSSVADFAMEMFDVVDEINYQSYND--------FVLRVGISVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGLPGKIQVSEDVYKILKQSNYEFTCRGKVTVKGKGEMLTY 854 HSP 3 Score: 82.4185 bits (202), Expect = 4.231e-16 Identity = 73/286 (25.52%), Postives = 131/286 (45.80%), Query Frame = 2
Query: 698 KYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLES-IRSKDLFNLGYCKQFKNVSILFADIVGFT----AMSSNKTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCV--------EMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV--------CHAYTFIEGEKLMVT--KERQFGLE 1477
K Y + I+LF + GL+ R + ++ + +L +Q + M+ + ++PA V FL+S R+ DL Y + + V +LFA I F + N + + LLN++ FD D + EKI T+G Y G A C + + + M ++ N + +RVG+ G V+A +IG R ++D++ N V++A+ ++S+G PGK+ +S+ +K++ C ++G+ M+T E + GLE
Sbjct: 585 KAYEPVLTILLF--ICAMGLHSRQLD-LKLRLDYLWASQAEDERGDMERVKNDNKRILFNLLPAHVAQHFLQSNPRNMDL----YYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELLDKECFKDIEKIKTIGSTYMAAVGLVPTSGTKAKCSIISHLSSVADFAMEMFDVVDEINYQSYNDFVLRVGISVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGLPGKIQVSEDVYKILKQSNYEFTCRGKVTVKGKGEMLTYFLEGKQGLE 863 HSP 4 Score: 63.1586 bits (152), Expect = 2.751e-10 Identity = 57/245 (23.27%), Postives = 100/245 (40.82%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKG-DVETYLALRPYETYMIYKHGKAK 3253
E + E+ L +++P++V ++ F Y + N ++FA I F S + +K+L+ + FD L +IK + DCY SGL + DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++ L + E G G D +YL ETY I + K
Sbjct: 61 ENEKQERLLMSLLPRHVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTS---LASQCTAQELVKLLNELFGKFDEL---ATENHCRRIKILGDCYYCVSGLTQP----KADHAHCCVEMGLDMIDTITSVAEATEVD---LNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKSTLDCLNGDYEVE-------PGNGKDRNSYLRKHNIETYFIVPSHRRK 285
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006025.1 (pep scaffold:Pmarinus_7.0:GL480980:9262:24123:1 gene:ENSPMAG00000005435.1 transcript:ENSPMAT00000006025.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 187.963 bits (476), Expect = 1.695e-50 Identity = 94/237 (39.66%), Postives = 150/237 (63.29%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV----RGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTF 1399
+ L+ +L G +RIF ++S F + ++ + ++ +D + Q + +++P V R +FL+ +F+ Y ++ +NVSILFADIVGFT M+S TA++LV LLN+L+++FD+ +C +I LGDCYYCVSG + ++DHA CCV+MGL M I + +NMRVG+H+GRV+ ++G ++++DV+SNDV++ANA+E+ G PGKVHI+K T
Sbjct: 164 WPKLLVNAVLLVSACACGGAVRIFTERVQRSTFRRTWESVRQRLLLDDENEKQERLLVSLLPRHVAIELRQDFLKP--PNHIFHKVYIQRHENVSILFADIVGFTGMASQCTAQELVKLLNELFSKFDELATENHCRRIKILGDCYYCVSGLALAKADHAHCCVKMGLDMIDTIDLVAEAMEVRLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANAMEAGGLPGKVHITKATL 398 HSP 2 Score: 64.3142 bits (155), Expect = 9.541e-11 Identity = 64/280 (22.86%), Postives = 120/280 (42.86%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIV----NAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKG-DVETYLALRPYETYMIYKHGKAKSYSE 3265
F R R + + R+ + +DE ++ E+ L +++P++V ++ D K + K + N ++FA I F +G + + +K+L+ + FD L +IK + DCY SGL A +KA DH + + D+++ + E V +++G + G V G++G K YD+W + V +A+ M + GK+ ++ L + E G G + YL ET+ I ++K++
Sbjct: 187 FTERVQRSTFRRTWESVRQRLLLDDENEKQ----ERLLVSLLPRHVAIEL--RQDFLKPPNHIFHKVYIQRHENVSILFADIVGF-TGMASQCT--AQELVKLLNELFSKFDEL---ATENHCRRIKILGDCYYCVSGL-ALAKA---DHAHCCVKMGLDMIDTIDLVAEAMEV---RLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANAMEAGGLPGKVHITKATLDGLRGDYEVE-------PGHGQERHCYLRKNNVETFFIVPSRRSKAFQR 440
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Match: adcy2a (adenylate cyclase 2a [Source:ZFIN;Acc:ZDB-GENE-061109-1]) HSP 1 Score: 166.392 bits (420), Expect = 2.467e-42 Identity = 78/175 (44.57%), Postives = 117/175 (66.86%), Query Frame = 2
Query: 923 SKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLM 1447
S + NL Y ++ K+VSIL+ADIVGFT ++S+ + +LV+ LN L+ +FD K +C +I LGDCYYCVSG P+ HA CV+MG+ MC+ I ++NMRVGVHSG V+ +IG ++++DV+S+DV++AN +E+ G PG+VHI++ T + + AY EG +
Sbjct: 42 SNNFHNL-YVRRHKSVSILYADIVGFTRLASDCSPAELVHTLNQLFGKFDQIAKDNDCMRIKILGDCYYCVSGLPISLPSHAKNCVKMGIDMCEAIKKVRYATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLEHLHGAYEVEEGRGFL 215 HSP 2 Score: 142.51 bits (358), Expect = 9.788e-35 Identity = 91/267 (34.08%), Postives = 143/267 (53.56%), Query Frame = 2
Query: 2435 LYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY-KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNAS------SKAYRE-DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETYLAL 3208
L L R+NE R+ F ++ + +E + L N++P +V + + Y ++ V+FASI +F Y D K G L++L+ II FD LL P + G+EKIKT+ YM A+GLNA+ + R+ H+ ++ F+ L+ +L N+ + +F L++G N GPV AG+IG KP YDIWG++VNV+SRM ST GKIQV++ L T + + RG + +KGKG+++T+ +
Sbjct: 591 LLVLARQNEYYCRLDFLWKQKFKKEREEIETMENLNRVLLENVLPAHVAEHFL---THHRKNEDLYHQSYECVCVMFASIPDFKEFYQESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAAVGQENGQEPERQYAHIGIMVEFAMALMGKLDVINKHSF---NNFRLRVGINHGPVIAGVIGAQKPQYDIWGNSVNVSSRMDSTGVLGKIQVTEETSDILQTLGYNCQCRGMIKVKGKGELKTFFVV 851 HSP 3 Score: 73.9442 bits (180), Expect = 1.683e-13 Identity = 52/195 (26.67%), Postives = 95/195 (48.72%), Query Frame = 2
Query: 869 IEAIMPAAVRGEFLESIR-SKDLFNLGYCKQFKNVSILFADIVGFTAM----SSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGC-----------PVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT 1396
+E ++PA V FL R ++DL++ Y + V ++FA I F NK + + LLN++ FD+ K EKI T+G Y +G P + H VE + + + N+ +RVG++ G VIA +IG + ++D++ N V++++ ++S+G GK+ ++++T
Sbjct: 630 LENVLPAHVAEHFLTHHRKNEDLYHQSY----ECVCVMFASIPDFKEFYQESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAAVGQENGQEPERQYAHIGIMVEFAMALMGKLDVINKHSFNNFRLRVGINHGPVIAGVIGAQKPQYDIWGNSVNVSSRMDSTGVLGKIQVTEET 820 HSP 4 Score: 51.9878 bits (123), Expect = 8.759e-7 Identity = 33/140 (23.57%), Postives = 70/140 (50.00%), Query Frame = 2
Query: 2801 KIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGK--GDVETYLALRP 3214
+IK + DCY SGL S ++ ++ K+ + + + ++ Y +I +++G + G V G+IG K YD+W V +A+ M + G++ +++ ++L + E G+ F++ ++T+L + P
Sbjct: 100 RIKILGDCYYCVSGLPISLPSHAKN-CVKMGIDMCEAIKKVRYATGVDI------NMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLEHLHGAYEVE-EGRGFLRDPYLTGMKTFLVINP 231
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Match: EDO47010 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN58]) HSP 1 Score: 214.927 bits (546), Expect = 5.062e-57 Identity = 130/368 (35.33%), Postives = 198/368 (53.80%), Query Frame = 2
Query: 482 ARFSLMVAVILMMYTLFH-LRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFL---------------------ESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFV 1519
ARFS+ IL++YT+ H LR I + +++ + + V Y N S ++++ +I + ++L ++L G+ + +R +S F K+ Q+ A+ ++ +V+ I ++MP V L + ++K +F + +NVSILFADIVGFT MSSNK+A QLV LLNDL+ RFD + +CEKI+TLGDCYYCV+GCP P +HA CVEMGL M + I F+ +V+MRVGVH+G V+ I+G RF+FDV+SNDV++AN +E++G PG+VHI++ T + Y G + R L+G + TYF+
Sbjct: 126 ARFSVCTCFILVIYTMLHSLRLYICIFITVAFSIA--HEVLYAFFGN-----------SKGQRLKGQGEEIASI-------VLLHACIHLIGISIFFMAQVRERSTFWKVGQSYVARRDLEIEKQVKERMIRSVMPEIVADSLLNVDDEDENKNGNGREMGNGKRKHKKAKMVFRPFQMHRMENVSILFADIVGFTKMSSNKSADQLVRLLNDLFGRFDRLTEYNHCEKISTLGDCYYCVAGCPKPTPNHATYCVEMGLDMLEQIKEFDNDTDNDVDMRVGVHTGTVLCGIVGTKRFKFDVWSNDVTLANRMETAGLPGRVHITEATVGFLRDQYIVENGHG----ETRNAALKG-------ITTYFI 462 HSP 2 Score: 181.8 bits (460), Expect = 1.296e-46 Identity = 173/533 (32.46%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1673 KMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQI----REININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYIS--------VLPTLLVHTLY-DAEKLYNNYEYTVGYFT-LTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQ--KLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVN-DCYMMASGLNASSKAYRE----DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLAL 3208
+ ND +L+ HL S+ + F P++ TL F D E+E +Q D S KV F D + + + + F L +L M PL I I L + + + F + F + HPL + + G + S LP V + + D +L +N +F+ + AL+ C FT S +K S AA + +LLQ D DF V + T+ ++ + L + LL+ L R+ E +R F EA +++ ++ A+ L ++ PK+V + T Y+ NAGV+FASI NF S +Y E+++ G+ ++VL+ ++ FD LL Y +EKIKTVN +M +GLN RE +HL +L+ F+ ++ N + +NE +++G K F L+IG+N GPVTAG+IGT+K LYDIWGDTVN+ASRM ST KIQVS+ + L F+FE RG + +KGKG V TYL L
Sbjct: 599 RTSNDQQLV-HLMSEQGVGDEYFH-APVSTCTLQFYDKELEQQYQNEGQDSTLLNPSVTTFASPKVNFFTDVLLSNIVFFTICVLCFLLF-------NPVSLSMMVLTPLAFIVE-ITLFFLNF--ARAFPRRFPQWFHPLVKNTSGWFTSHIVGALLMCLPMATVFSNFMDCSQLADNNARN--FFSYIVAVALLHFCNFTQLTSWMK-TSLAAVFTMTYIILLQ----FD--------DFCVRAAPMTTEGSRMAKEVTAALVLLWLLVALLNRQLEMGVRRNFSGDAEAAKVKKKSQVHKQQADWLLLSLFPKHV--------SEALKTSDHYSMNYNNAGVMFASIVNF-SDFYEENFEGGKECIRVLNELVGDFDELLDNIEYMEVEKIKTVNGSTFMAGAGLNQEDNIRREIHPYEHLKQLVEFALEMFNVVDRFNE-HMLGFK-FKLRIGFNAGPVTAGVIGTTKLLYDIWGDTVNLASRMDSTGVPEKIQVSESTKEMLNDFFIFERRGTIPVKGKGYVTTYLYL 1093 HSP 3 Score: 71.2478 bits (173), Expect = 1.944e-12 Identity = 63/300 (21.00%), Postives = 131/300 (43.67%), Query Frame = 2
Query: 2423 ICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKST------------KFSYAKTIV---------NAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIY--KHGKAK 3253
I + ++F+ + E++ F+ ++ + + E++V E+ + +++P+ V + D+ ++ K AK + N ++FA I F K + +++L+++ FD RL Y EKI T+ DCY +G + +H + D+L Q+ ++ + + +++G + G V GI+GT + +D+W + V +A+RM + G++ +++ +L ++ E G G+ AL+ TY I K+G K
Sbjct: 196 IGISIFFMAQVRERST---FWKVGQSYVARRDLEIEKQVKERMIRSVMPEIVADSLLNVDDEDENKNGNGREMGNGKRKHKKAKMVFRPFQMHRMENVSILFADIVGFTK---MSSNKSADQLVRLLNDLFGRFD---RLTEYNHCEKISTLGDCYYCVAGCPKPTP----NHATYCVEMGLDMLEQIKEFDNDT---DNDVDMRVGVHTGTVLCGIVGTKRFKFDVWSNDVTLANRMETAGLPGRVHITEATVGFLRDQYIVE-------NGHGETRN-AALKGITTYFIVGRKNGMKK 471 HSP 4 Score: 70.4774 bits (171), Expect = 3.736e-12 Identity = 56/219 (25.57%), Postives = 110/219 (50.23%), Query Frame = 2
Query: 824 AKMKMDSAI-KVQIYWIE-AIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSN--KTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSGCPVPRSD----------HALCCVEMGLGMCKMILAFNR-LHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTF 1426
AK+K S + K Q W+ ++ P V E++++ D +++ Y N ++FA IV F+ + K+ + +LN+L FD D + M EKI T+ + ++G + + D H VE L M ++ FN + + +R+G ++G V A +IG + +D++ + V++A+ ++S+G P K+ +S+ T +++ + F
Sbjct: 864 AKVKKKSQVHKQQADWLLLSLFPKHVS----EALKTSDHYSMNY----NNAGVMFASIVNFSDFYEENFEGGKECIRVLNELVGDFDELLDNIEYMEVEKIKTVNGSTF-MAGAGLNQEDNIRREIHPYEHLKQLVEFALEMFNVVDRFNEHMLGFKFKLRIGFNAGPVTAGVIGTTKLLYDIWGDTVNLASRMDSTGVPEKIQVSESTKEMLNDFFIF 1073
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Match: EDO45868 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRQ7]) HSP 1 Score: 195.282 bits (495), Expect = 6.914e-51 Identity = 100/252 (39.68%), Postives = 151/252 (59.92%), Query Frame = 2
Query: 692 PNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS----KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEG 1435
PN +L+G ++LF +TG++ I ++ AFL+ + +A++ + + Q + +++P V E + I S F+ Y ++ +NVSILFADI GFT +SS TA+ L+ LN+LY RFD +C +I LGDCYYCVSG P PR DHA C+EMGL M I + +NMRVGVH G+V + ++G +++++DV+S+DV+IAN +ES G PG+VHI+K+ + Y EG
Sbjct: 248 PNLARLLVGNLLLFICANITGVFTHYPTEISQRQAFLETRRCIEARLTIQKENQNQERLLLSVLPRYVAMEMKDDIESGISQNSQFHKIYIQRHENVSILFADIEGFTVLSSQCTAQSLIKTLNELYARFDQLAVENHCLRIKILGDCYYCVSGLPDPRPDHAHSCIEMGLAMIDAISFVRDATQVNLNMRVGVHMGKVHSGVLGLVKWQYDVWSDDVTIANHMESGGLPGRVHITKEVLDCLNGDYEVEEG 499 HSP 2 Score: 155.992 bits (393), Expect = 1.523e-38 Identity = 100/272 (36.76%), Postives = 150/272 (55.15%), Query Frame = 2
Query: 2456 NEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGES--ALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS--KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKS 3256
+E+ R+ F +A E + R+ +K LYNI+P +V G +K Y ++ V+F++I NF S +Y E GE L++L+ I+ FD LL P ++ +EKIKT+ + YM ASG+ S K +H+ + F+ + +L + N+ +F +KIG NFGPV AG+IG KP YDIWGDTVNVASRMYST IQV+ +++ L+T + F+ RG V +KGKG + TY +++ K G + S
Sbjct: 792 HEQISRLDFLWKLQATEEKKEMEQLREYNKKLLYNILPVHVAQHFLGHKANKNEDL--YYQSCDKVAVMFSNICNF-SDFYTELDANGEGVECLRLLNEILADFDELLSEPQFQCIEKIKTIGETYMAASGIKPESQEKLATLNHICTMADFAMAMKRKL---EDINLHSFNNFAMKIGLNFGPVVAGVIGAHKPQYDIWGDTVNVASRMYSTGKDNHIQVTKAMYEILSTRGYTFDCRGLVAVKGKGKMVTY--------WLLGKEGASNS 1049 HSP 3 Score: 78.5666 bits (192), Expect = 9.948e-15 Identity = 85/342 (24.85%), Postives = 162/342 (47.37%), Query Frame = 2
Query: 503 AVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFL--ESIRSKDLFNLGYCKQFKNVSILFADIVGF----TAMSSNKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVN--------MRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV--------CHAYTFIEGEKLMVT 1453
AV L + T+ L+F + +++IVYIL+ V Y + N H+ +F S H I ++ L I++ F++ LT + + I R KL Q + K +M+ + + I+P V FL ++ +++DL Y + V+++F++I F T + +N + + LLN++ FD+ + EKI T+G+ Y SG P S L + M +A R E++N M++G++ G V+A +IG + ++D++ + V++A+ + S+GK + ++K ++++ C ++G+ MVT
Sbjct: 718 AVFLQLSTV--LKFSLLTVMAIVYILL----VQY-VAKNSFLRHDFLQFCGL-----GSGHFI--EWSDLSILIVVIFILALTA-HGYLHEQISRLDFLWKL-QATEEKKEMEQLREYNKKLLYNILPVHVAQHFLGHKANKNEDL----YYQSCDKVAVMFSNICNFSDFYTELDANGEGVECLRLLNEILADFDELLSEPQFQCIEKIKTIGETYMAASGIK-PESQEKLATLNHICTMADFAMAMKR-KLEDINLHSFNNFAMKIGLNFGPVVAGVIGAHKPQYDIWGDTVNVASRMYSTGKDNHIQVTKAMYEILSTRGYTFDCRGLVAVKGKGKMVT 1037 HSP 4 Score: 73.559 bits (179), Expect = 3.905e-13 Identity = 47/203 (23.15%), Postives = 94/203 (46.31%), Query Frame = 2
Query: 2522 RRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIV----NAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYV 3118
++E + E+ L +++P+YV ++ + S + K + N ++FA I F +S +K L+ + FD +L + +IK + DCY SGL R DH + + +++ +++ + V + +++G + G V +G++G K YD+W D V +A+ M S G++ ++ V
Sbjct: 297 QKENQNQERLLLSVLPRYVAMEMKDDIESGISQNSQFHKIYIQRHENVSILFADIEGF---TVLSSQCTAQSLIKTLNELYARFD---QLAVENHCLRIKILGDCYYCVSGLPDP----RPDHAHSCIEMGLAMIDAISFVRDATQV---NLNMRVGVHMGKVHSGVLGLVKWQYDVWSDDVTIANHMESGGLPGRVHITKEV 486
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Match: EDO42810 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0C5]) HSP 1 Score: 163.31 bits (412), Expect = 9.745e-41 Identity = 125/409 (30.56%), Postives = 199/409 (48.66%), Query Frame = 2
Query: 710 LIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIR-------SKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHK--EEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGE--------------KLMVTKERQF--GLEGFAPTLV-PMPTYFVESYSTEFDEYFNRK--VID------ESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIRE 1834
L+ ++F + G +++ + L+ ++ + K+ +D+ + Q + +++P V E + + + F + + SILFADIVGFT +SS TA+QL+ LN+L+ FD +C +I LGDCYYC+SG +HALC V MGL M + I A R K + +NMRVG+H+G V+A ++G +++F+ +SNDV++AN +ES G PG+VHIS+ T + + +G+ ++T+ + G + TLV P T + S+ E N K +I + SY + EKS+ S S +EKM N L L L ERTV Q +NP+TL FK+ ++E + D E
Sbjct: 270 LVANTLVFVCANILGAIDYHIADRKQRRSVLETRESLEVKLTLDAQNQQQRRLLLSVLPKHVAEEMTKDFEGDGNPALTDNAFKKLFIRTHDTCSILFADIVGFTELSSKCTAEQLIVTLNELFANFDKLAAKNHCLRIKILGDCYYCISGLD-DSCNHALCAVNMGLDMVEHI-AHVREEKGVKSLNMRVGIHTGMVLAGVLGQRKWQFEAWSNDVTLANHMESGGIPGRVHISEPTLNSIKDYFEVEDGDGGSRDDYLADKKIKTYLITQAKPIWDGEKEDLDTLVLPPETSPEKRRSSSPPEVANDKDSIIGRDGNRRRTSSYMEDSEKSDASTTS--------------NEKMLNKL-LCEVLD---ERTVGKIQE-DMNPVTLRFKNYDVEYQYALEKQDMCSE 657 HSP 2 Score: 144.05 bits (362), Expect = 1.008e-34 Identity = 84/204 (41.18%), Postives = 123/204 (60.29%), Query Frame = 2
Query: 2600 ADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY--KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRE-DHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
AD+KK Y+ + V+FASI NF S +Y ED G +++L+ +I FD +L P + G+EKIKT++ YM ASGL S+ E +L ++ F+ L ++L + N+E+ F L++G GP+ AG+IG KP YDIWG+TVNVASRM +T AG IQ++ ++ + F+F YRG V +KGKG + TY
Sbjct: 881 ADEKKKEDL-YSHSYKRVSVMFASIPNF-SEFYSEDNINNGGVECIRLLNEVITDFDEVLADPRFLGVEKIKTISSTYMAASGLRPESEDAEESQNLVDIVDFALTLRDKLDFINQESF---NQFVLRVGICQGPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQTYETIKDKDFVFVYRGAVRVKGKGQLITY 1079 HSP 3 Score: 70.4774 bits (171), Expect = 3.428e-12 Identity = 45/167 (26.95%), Postives = 85/167 (50.90%), Query Frame = 2
Query: 947 YCKQFKNVSILFADIVGFTAMSS----NKTAKQLVYLLNDLYNRFDDF---GKIMNCEKIATLGDCYYCVSGCPVPRSDHA------LCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
Y +K VS++FA I F+ S N + + LLN++ FD+ + + EKI T+ Y SG P S+ A + V+ L + + N+ + +RVG+ G ++A +IG + +D++ N V++A+ +E++GK G + I+ +T++ +
Sbjct: 890 YSHSYKRVSVMFASIPNFSEFYSEDNINNGGVECIRLLNEVITDFDEVLADPRFLGVEKIKTISSTYMAASGLR-PESEDAEESQNLVDIVDFALTLRDKLDFINQESFNQFVLRVGICQGPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQTYETI 1055 HSP 4 Score: 64.6994 bits (156), Expect = 1.826e-10 Identity = 57/253 (22.53%), Postives = 109/253 (43.08%), Query Frame = 2
Query: 2501 EIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFS-------YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYK 3238
+ +N + RR L +++PK+V ++T + + + + +T ++FA I F + E + L+ + FD +L +IK + DCY SGL+ S +H + D++ +A+ EE G K +++G + G V AG++G K ++ W + V +A+ M S G++ +S+ + +F E G + YLA + +TY+I +
Sbjct: 313 DAQNQQQRR-------LLLSVLPKHVAEEMTKDFEGDGNPALTDNAFKKLFIRTHDTCSILFADIVGFTELSSK---CTAEQLIVTLNELFANFD---KLAAKNHCLRIKILGDCYYCISGLDDSC-----NHALCAVNMGLDMVEHIAHVREEK--GVKSLNMRVGIHTGMVLAGVLGQRKWQFEAWSNDVTLANHMESGGIPGRVHISEPTLNSIKDYFEVED------GDGGSRDDYLADKKIKTYLITQ 539
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Match: EDO47086 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN72]) HSP 1 Score: 114.39 bits (285), Expect = 3.656e-26 Identity = 58/152 (38.16%), Postives = 92/152 (60.53%), Query Frame = 2
Query: 950 CKQFKNVSILFADIVGFTAMSSNK--TAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMI-LAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKT 1396
+ +K V+ILF+DIVGFTA+ SN +V +LN LY FD + + K+ T+GD Y V G P P DHA MGLGM + + + + +E + +R+G+H+G V+A ++G R+ ++ N V++AN +ES +PG+++IS T
Sbjct: 429 AESYKTVTILFSDIVGFTALCSNDKIVPMDIVKMLNRLYTYFDMLSGMNDVYKVETIGDAYMVVGGLPHPCEDHADRVASMGLGMMEAADVVLSPVDREPLKIRIGIHTGPVMAGVVGKKMPRYCLFGNTVTLANKMESGTQPGRINISIDT 580 HSP 2 Score: 58.151 bits (139), Expect = 1.373e-8 Identity = 49/193 (25.39%), Postives = 91/193 (47.15%), Query Frame = 2
Query: 2531 RKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVS 3109
+K + LY+I+PK V ++ + +S KT+ ++F+ I F + D +K+L+ + FD L + + K++T+ D YM+ GL EDH ++ ++ + V + ++IG + GPV AG++G P Y ++G+TV +A++M S G+I +S
Sbjct: 402 KKRTDDLLYSILPKEVAAKLRLN----QSVPAESYKTVT---ILFSDIVGF-TALCSNDKIVPMDIVKMLNRLYTYFDMLSGM---NDVYKVETIGDAYMVVGGLPHPC----EDHADRVASMGLGMMEAADVV--LSPVDREPLKIRIGIHTGPVMAGVVGKKMPRYCLFGNTVTLANKMESGTQPGRINIS 577
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Match: EDO34267 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPS8]) HSP 1 Score: 110.153 bits (274), Expect = 3.902e-26 Identity = 74/235 (31.49%), Postives = 124/235 (52.77%), Query Frame = 2
Query: 803 KLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV-----RGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSD-HALCCVEMGLGM-----CKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFI---EGEKLMVTKERQ 1465
K Q + K K D+ +E ++P V RG+ +E+ + F VSI F+DIVGFT +S+ + Q+V LLNDLY FDD + + K+ T+GD Y VSG P+ + HA +M L + + I+ + +K + +RVG+HSG V+A ++GN R+ ++ + V+ A+ +ES+G+ ++HIS+ T +++ F+ GE + + RQ
Sbjct: 101 KTGQLIEEKKKTDA-------LLERMLPKPVTDQLKRGKSVEA------------ESFHEVSIYFSDIVGFTELSAESSPLQVVSLLNDLYTLFDDIIREYDVYKVETIGDAYMVVSGLPIRNGNRHAGEIAKMALHLIEAVQTEFIVRYKPTYK--LKLRVGIHSGPVVAGVVGNTMPRYCLFGDTVNTASRMESNGEALRIHISEDTKRILDQLGGFVVEGRGEVYLKVRRRQ 314 HSP 2 Score: 77.7962 bits (190), Expect = 2.482e-15 Identity = 65/224 (29.02%), Postives = 108/224 (48.21%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKV---LHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFY---LKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT--HFLFEYRGKVFMK 3175
E+K + L ++PK V Q+ K K A++ + F+ I F + S L+V L+++ FD+++R + K++T+ D YM+ SGL + + K+ L + + E IV K Y L++G + GPV AG++G + P Y ++GDTVN ASRM S A +I +S+ + L F+ E RG+V++K
Sbjct: 108 EKKKTDALLERMLPKPVTDQL-------KRGKSVEAESFHEVSIYFSDIVGF------TELSAESSPLQVVSLLNDLYTLFDDIIR---EYDVYKVETIGDAYMVVSGLPIRNGNRHAGEIAKMALHLIEAVQT------EFIVRYKPTYKLKLRVGIHSGPVVAGVVGNTMPRYCLFGDTVNTASRMESNGEALRIHISEDTKRILDQLGGFVVEGRGEVYLK 309
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Match: adcy3b (adenylate cyclase type 3 [Source:NCBI gene;Acc:101167167]) HSP 1 Score: 318.546 bits (815), Expect = 1.479e-91 Identity = 258/891 (28.96%), Postives = 416/891 (46.69%), Query Frame = 2
Query: 692 PNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDL---------FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIE----GEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNE---EKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSD--PERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALI-----SNCIFTISY----SVLKQMSTAACTA-------GSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKL-----KYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGE-SALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSK--------------AYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKGKGDVETY 3199
P L+ ++L+ L G+ + ++AFL+ Q+ Q K+ ++ Q + +I+P + E L+ ++++ FN Y + +NVSILFADIVGFT +SS +A++LV LLN+L+ RFD + +I LGDCYYC+ G P R DHA+C + MGL M + I + K +V+MRVGVH+G V+ ++G R++FDV+S DV++AN +ES G PG+VHIS+ T K H +E GE+ E+ G+E + LVP T ++ R+ +D S N+ K+ + S + + +A K KM + + R LQ + + Q ++ +NP++L F D ++E H+ +S K A +C + F I+A + I+ + TL + L + + ++ +F K V FS + R + + V T+ + + ++ F T ++ + C Y +V+ ++TA G + L++ ++IY + D L DY++ + KY + + + + YF R E R F + ++ R+ E + N++P++V G+ KK + Y+++ GV+FASI NF Y E G L++L+ II FD+LL ++ + KIKT+ YM ASGL S R HL L F+ + L N+++ +F L+IG N G V AG+IG KP YDIWG+TVNVASRM ST G IQV + L + F F RG +F+KGKG++ T+
Sbjct: 222 PMLVRQLLANVMLYVGATLVGVMSFYMADRKYRTAFLEARQSLQVKLTLEEQSTQQEELLLSILPKHIADEMLQGMKNQADQTDVQQQQQFNTMYMYRHENVSILFADIVGFTQLSSTCSAQELVKLLNELFARFDKLAAQYHQLRIKILGDCYYCICGLPDFREDHAVCSIMMGLAMVEAISYVREMTKTDVDMRVGVHTGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGRVHISQST-KDSLHGEFEVEPGSGGERCEYLLEK--GIETYL-VLVPKQT----------EQGLKRETLDNVGSRNSNQLINTKATQGNTSSLQLVPTA--SKQERNKMIEEQAINRRLQQELLDRESQQIMKDHKINPVSLCFVDKKLEEHY-------------SSEKEKRSGAAFSCCIIVLF-FITAMEVFIDPLLVVNYVTLAIGEVLLLTLTLCSLAAIFP-----RMFSKRLVSFSMWIDRTRWARNTWAMAAIFVLTMAVIADMLSCVPSSLRVFNSTMGPVLESLGDNGCAENPKYYSFMAVMSLIATAMLVQVSHIIKLGLMMLVVTAAGAVNIYSWKDIFD-LYDYIQFASYGTSMVPSKYLMTVMIIVMMISFYFFARHLEHQSRKLFLWKIGVHDQKEKVLEIRRWNEALVTNMLPEHVAKHFLGT---KKRDEELYSQSYDETGVMFASIPNFSDFYTEEGINNGGIECLRILNEIISDFDSLLDRDEFQCITKIKTIGSTYMAASGLTPGSNTNGYSNCKSENRSLTERWQHLADLADFALAMKVTLDNLNKQSF---NNFMLRIGMNKGAVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCFDILKEYGFRFIRRGPIFVKGKGELLTF 1070 HSP 2 Score: 63.929 bits (154), Expect = 9.024e-10 Identity = 61/272 (22.43%), Postives = 116/272 (42.65%), Query Frame = 2
Query: 689 IPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAI----MPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGF----TAMSSNKTAKQLVYLLNDLYNRFD---DFGKIMNCEKIATLGDCYYCVSG------------CP------VPRSDHALCCVEMGLGMCKMILAFNRLHKEEVN---MRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLV 1408
+P+KY M + I++ Y + R RK K+ + Q + ++++ W EA+ +P V FL + + + Y + + ++FA I F T N + + +LN++ + FD D + KI T+G Y SG C R H + L M + + L+K+ N +R+G++ G V+A +IG + +D++ N V++A+ +ES+G G + + + F ++
Sbjct: 789 VPSKYLMTVMIIVMMISFYF---FARHLEHQSRKLFLWKIGVHDQK----EKVLEIR-RWNEALVTNMLPEHVAKHFLGTKKRDEEL---YSQSYDETGVMFASIPNFSDFYTEEGINNGGIECLRILNEIISDFDSLLDRDEFQCITKIKTIGSTYMAASGLTPGSNTNGYSNCKSENRSLTERWQHLADLADFALAM---KVTLDNLNKQSFNNFMLRIGMNKGAVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCFDIL 1046
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Match: adcy8 (adenylate cyclase 8 [Source:NCBI gene;Acc:101161086]) HSP 1 Score: 305.064 bits (780), Expect = 4.239e-86 Identity = 253/886 (28.56%), Postives = 420/886 (47.40%), Query Frame = 2
Query: 716 GQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGE-KLMVTKERQFGLEGF-----APTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRD--EKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCS----TFVIISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYN----NYEYTVG---------YFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKL---KYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED--HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETY 3199
Q +LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +++MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK + Y EG K R+ +E + +++ +P ++ + D + +E+ S E I ++ L R+ + N L H+ S PE R+ + + P +L FKD+ +E + + D++ + N + S V ++ I C + S T I + +++ S I TT Y +PL++ WI Y + + +IF + I I+ L ++ D +K N Y +V YF T A+++ +F SVLK ++ LL+ + + + + D V T+ K + L +++ ++ E R+ F +A+ +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL +L F+ L + N+ + +F L+IG G V AG+IG KP YDIWG TVN+ASRM ST +GKIQV + + L F FEYRG++++KG +G + T+
Sbjct: 299 AQAVLFLCMNTAGIFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIETYLIKQPEESMLALPEDIMKEAVSSADRRASSATFNEAS-------WSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVHSGPEEINKRIESAIDLRSGDKLRREHIKPFSLMFKDSSLEEKYS-QMRDEVFKSNLVCSFIVLIYITTIQCLLPSASKVTMAIQFSILIVLHSCLILVTTAEDYKC-LPLVLRKTCCWINETYAA--------RNVIIF--------VSILINFLAAMINILWCDFDKSSNFRNQTYNESVSIPDICFYPEYFVFTGVLAMVTCAVFLRLNSVLKL---------AVLLLMIAIYSLLTEAFYTSLFIRYDTVHHNTENFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPDKQQCEDKWGHLCELADFAIALNESIQEINKHSF---NNFELRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQVPEDTYLILKDRGFAFEYRGEIYVKGISEQEGKIRTH 1144 HSP 2 Score: 64.3142 bits (155), Expect = 7.245e-10 Identity = 64/277 (23.10%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R DH + + ++ + Y KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ + ++ETYL +P E+ +
Sbjct: 313 FISYLSDRAQRQAFLETRRCIEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RPDHAHCCVEMGLSMIKTIRYVRSRT----KHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLR-RHNIETYLIKQPEESML 571
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Match: adcy8 (adenylate cyclase 8 [Source:NCBI gene;Acc:101161086]) HSP 1 Score: 305.064 bits (780), Expect = 4.488e-86 Identity = 253/886 (28.56%), Postives = 420/886 (47.40%), Query Frame = 2
Query: 716 GQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRS------KDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGE-KLMVTKERQFGLEGF-----APTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRD--EKMKNDLELIRHLQSDPE------------RTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREIN-INSVKVALFFDAIACQVCS----TFVIISAFFLIIESGGISKTTTLVYMSGIPLIM--IAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYN----NYEYTVG---------YFTLT-FFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKL---KYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYR-EDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED--HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATH-FLFEYRGKVFMKG----KGDVETY 3199
Q +LF + G+++ + ++ AFL+ + +A++++++ + Q + +++P V E + + + + F+ Y +++NVSILFAD+ GFT +S+ +A++LV +LN+L+ RFD +C +I LGDCYYCVSG P PR DHA CCVEMGL M K I K +++MR+G+HSG V+ ++G +++FDV+S DV IAN LES G PG++HISK + Y EG K R+ +E + +++ +P ++ + D + +E+ S E I ++ L R+ + N L H+ S PE R+ + + P +L FKD+ +E + + D++ + N + S V ++ I C + S T I + +++ S I TT Y +PL++ WI Y + + +IF + I I+ L ++ D +K N Y +V YF T A+++ +F SVLK ++ LL+ + + + + D V T+ K + L +++ ++ E R+ F +A+ +E + R+ E L NI+P +V D + Y+++ GV+FASI F Y + E +G L++L+ II FD LL ++ +EKIKT+ YM SGL+ + + HL +L F+ L + N+ + +F L+IG G V AG+IG KP YDIWG TVN+ASRM ST +GKIQV + + L F FEYRG++++KG +G + T+
Sbjct: 299 AQAVLFLCMNTAGIFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIETYLIKQPEESMLALPEDIMKEAVSSADRRASSATFNEASW-------SPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVHSGPEEINKRIESAIDLRSGDKLRREHIKPFSLMFKDSSLEEKYS-QMRDEVFKSNLVCSFIVLIYITTIQCLLPSASKVTMAIQFSILIVLHSCLILVTTAEDYKC-LPLVLRKTCCWINETYAA--------RNVIIF--------VSILINFLAAMINILWCDFDKSSNFRNQTYNESVSIPDICFYPEYFVFTGVLAMVTCAVFLRLNSVLKL---------AVLLLMIAIYSLLTEAFYTSLFIRYDTVHHNTENFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEEL---YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPDKQQCEDKWGHLCELADFAIALNESIQEINKHSF---NNFELRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQVPEDTYLILKDRGFAFEYRGEIYVKGISEQEGKIRTH 1144 HSP 2 Score: 64.3142 bits (155), Expect = 7.369e-10 Identity = 64/277 (23.10%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 2441 FLTRENEKNIRIFFYASR---EAEIRNDEARRERKVAEKFLYNIIPKYVFFQI----TGSADDKKSTKFS--YAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKH-FYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF-LFEYRGK---VFMKGKGDVETYLALRPYETYM 3229
F++ +++ R F +R EA +R E + E+ + +++P++V ++ T D+ +F Y N ++FA + F + + +++L+ + FD RL +IK + DCY SGL R DH + + ++ + Y KH ++IG + G V G++G K +D+W V++A+++ S G+I +S L + + E GK F++ + ++ETYL +P E+ +
Sbjct: 313 FISYLSDRAQRQAFLETRRCIEARLR---LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN---LSTTLSAQELVRMLNELFARFD---RLAHEHHCLRIKILGDCYYCVSGLPEP----RPDHAHCCVEMGLSMIKTIRYVRSRT----KHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLR-RHNIETYLIKQPEESML 571
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Match: adcy2a (adenylate cyclase type 2-like [Source:NCBI gene;Acc:101172459]) HSP 1 Score: 303.908 bits (777), Expect = 7.255e-86 Identity = 261/914 (28.56%), Postives = 432/914 (47.26%), Query Frame = 2
Query: 704 YMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV----RGEFLESIRSKDL--------FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLE--GFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKS----------------------YERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESG-GISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIF--RKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDA-----------------EKLYNNYEYTVGY-----FTLTFF------ALISNCIF-TISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQT----QKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY-KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS--------KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
+ ++ +I+F + G Y + + K + ++ +K++ + Q + +++PA + + E ++ ++ + F+ Y ++ NVSIL+ADIVGFT ++S+ + +LV++LN+L+ +FD K C +I LGDCYYCVSG P DHA CV+MGL MC+ I ++NMRVGVHSG V+ +IG ++++DV+S+DV++AN +E+ G PG+VHI+ T + + AY +G+ +ER L+ G LV P VE +S + + Y R + +K + R+ + K S + F+ R E+ K+ + R + ER ++ F L +D + S F FH +E ++ ++ AC + I+ L + GIS + + I I G + KSE S ++ R +I + P R+S+ + + L +L+ +++ E L+ + + V + F L +F LIS +F I+Y + + +A ++ +L + +D EYS FL + + LK S LF + L L R+NE R+ F + + +E + L N++P +V A + K+ Y ++ V+FASI +F Y D K G L++L+ II FD LL P + G+EKIKT+ YM A+GLNASS + + H+ ++ F+F L+ +L N+ + F L++G N GPV AG+IG KP YDIWG+TVNVASRM ST GKIQV++ L T ++ RG + +KGKG+++T+
Sbjct: 296 WQILANVIIFMCGNMAGAYHKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLKGPNFGQTENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLPDHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGDG----QERDPYLKEHGVITYLVINPK--VERWSPQ-NHYRPRHIHYGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKISTADVPMGQYHFQRRSERTKSQKK--RFEEELTERMIRTFDGINAQKQWLKSEDIQRISLF-FHNRSLEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTTVLGISFGLAFLVLLFILFICFIGHVLHCSKSESTSWLWLLRSSVIIANKPWPRISLTMTTTAL--ILIMAVFNMFFLDKRASPPVFNNSSNETLFYSNDQQVPFIGKNNFYLPYFIYSCILGLISCSVFLRINYELKMIIMLSAVVVYNVIILQTHSSLLD--EYSR---FLYKTESLDRPGVLKNLKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFL--ARNWKNEDL-YHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNASSGPEHTCQERDRQYMHIGTMVEFAFALVGKLDVINKHSF---NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETSLILLTLGYMCSCRGIINVKGKGELKTF 1186 HSP 2 Score: 54.299 bits (129), Expect = 8.861e-7 Identity = 57/274 (20.80%), Postives = 110/274 (40.15%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQIT------------GSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETYLALRP-YETYMIYKHGKAKSYSEYQKM*NSLKVA 3298
E++ E+ L +++P ++ + G ++ + Y + N +++A I F D GE + +L+ + FD + + +IK + DCY SGL S DH + D+ + + V +++G + G V G+IG K YD+W V +A+ M + G++ ++ ++L + E ++K G V TYL + P E + H + + KM S+++
Sbjct: 343 EKRQQERLLLSLLPAHIARVMKAEIIQRLKGPNFGQTENTNNFHNLYVQRHTNVSILYADIVGFTR--LASDCSPGE-LVHMLNELFGKFDQIAK---ENECMRIKILGDCYYCVSGLPES----LPDHAKNCVKMGLDMCEAIKKVRDATGVD---INMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGDGQERDPYLKEHG-VITYLVINPKVERWSPQNHYRPRHIHYGAKMRASVRMT 602
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Match: adcy2a (adenylate cyclase type 2-like [Source:NCBI gene;Acc:101172459]) HSP 1 Score: 302.368 bits (773), Expect = 1.471e-85 Identity = 261/915 (28.52%), Postives = 432/915 (47.21%), Query Frame = 2
Query: 701 YYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAV----RGEFLESIRSKDL--------FNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLE--GFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKS----------------------YERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESG-GISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIF--RKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDA-----------------EKLYNNYEYTVGY-----FTLTFF------ALISNCIF-TISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQT----QKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDY-KRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASS--------KAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLAT-HFLFEYRGKVFMKGKGDVETY 3199
+ ++ +I+F + G Y + + K + ++ +K++ + Q + +++PA + + E ++ ++ + F+ Y ++ NVSIL+ADIVGFT ++S+ + +LV++LN+L+ +FD K C +I LGDCYYCVSG P DHA CV+MGL MC+ I ++NMRVGVHSG V+ +IG ++++DV+S+DV++AN +E+ G PG+VHI+ T + + AY +G+ +ER L+ G LV P VE +S + + Y R + +K + R+ + K S + F+ R E+ K+ + R + ER ++ F L +D + S F FH +E ++ ++ AC + I+ L + GIS + + I I G + KSE S ++ R +I + P R+S+ + + L +L+ +++ E L+ + + V + F L +F LIS +F I+Y + + +A ++ +L + +D EYS FL + + LK S LF + L L R+NE R+ F + + +E + L N++P +V A + K+ Y ++ V+FASI +F Y D K G L++L+ II FD LL P + G+EKIKT+ YM A+GLNASS + + H+ ++ F+F L+ +L N+ + F L++G N GPV AG+IG KP YDIWG+TVNVASRM ST GKIQV++ L T ++ RG + +KGKG+++T+
Sbjct: 241 WDQILANVIIFMCGNMAGAYHKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLKGPNFGQTENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLPDHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGDG----QERDPYLKEHGVITYLVINPK--VERWSPQ-NHYRPRHIHYGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKISTADVPMGQYHFQRRSERTKSQKK--RFEEELTERMIRTFDGINAQKQWLKSEDIQRISLF-FHNRSLEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTTVLGISFGLAFLVLLFILFICFIGHVLHCSKSESTSWLWLLRSSVIIANKPWPRISLTMTTTAL--ILIMAVFNMFFLDKRASPPVFNNSSNETLFYSNDQQVPFIGKNNFYLPYFIYSCILGLISCSVFLRINYELKMIIMLSAVVVYNVIILQTHSSLLD--EYSR---FLYKTESLDRPGVLKNLKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFL--ARNWKNEDL-YHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNASSGPEHTCQERDRQYMHIGTMVEFAFALVGKLDVINKHSF---NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETSLILLTLGYMCSCRGIINVKGKGELKTF 1132 HSP 2 Score: 53.9138 bits (128), Expect = 9.628e-7 Identity = 57/274 (20.80%), Postives = 110/274 (40.15%), Query Frame = 2
Query: 2528 ERKVAEKFLYNIIPKYVFFQIT------------GSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFE----YRGKVFMKGKGDVETYLALRP-YETYMIYKHGKAKSYSEYQKM*NSLKVA 3298
E++ E+ L +++P ++ + G ++ + Y + N +++A I F D GE + +L+ + FD + + +IK + DCY SGL S DH + D+ + + V +++G + G V G+IG K YD+W V +A+ M + G++ ++ ++L + E ++K G V TYL + P E + H + + KM S+++
Sbjct: 289 EKRQQERLLLSLLPAHIARVMKAEIIQRLKGPNFGQTENTNNFHNLYVQRHTNVSILYADIVGFTR--LASDCSPGE-LVHMLNELFGKFDQIAK---ENECMRIKILGDCYYCVSGLPES----LPDHAKNCVKMGLDMCEAIKKVRDATGVD---INMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGDGQERDPYLKEHG-VITYLVINPKVERWSPQNHYRPRHIHYGAKMRASVRMT 548
BLAST of Adenylate cyclase type vs. Planmine SMEST
Match: SMESG000050966.1 (SMESG000050966.1) HSP 1 Score: 2165.58 bits (5610), Expect = 0.000e+0 Identity = 1050/1050 (100.00%), Postives = 1050/1050 (100.00%), Query Frame = 2
Query: 128 MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSEYQKM 3277
MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSEYQKM
Sbjct: 1 MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSEYQKM 1050
BLAST of Adenylate cyclase type vs. Planmine SMEST
Match: SMESG000050971.1 (SMESG000050971.1) HSP 1 Score: 1696.4 bits (4392), Expect = 0.000e+0 Identity = 808/1051 (76.88%), Postives = 926/1051 (88.11%), Query Frame = 2
Query: 128 MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITK-----FTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSE 3265
M K++K+L+V+SL+STAFSEYFHMLMTVHN+KSIRNGTKV+I YFC EII SHM +R++I+ PIVALIAF +F + LT NV+ + TMIS+AS+MVV CM+YSVI+ +D +EM+E R SLMVA ILMM+TLFHLRFLIT++LSIVYILIF+SAVNYRL + HN+T+ + L VR +H I +KY +L+ + +LFF VYL GLYLR FNSIRRKSAFLKLAQNAQAKMKM+SAI+VQIYWIEAIMP+AV+ EFL+++R KD FNL YC+QFK+VSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFG IMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMI+ FN++HKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHIS+KTFKLVCHAYTF+EGEKLM+ KER+FGLEGFA TLVP+PTYFVES TE+DEYFNR ++ESK YER EK ES + IDKS+L FK+RDEKMKNDL+LIRHLQSDPE+TVQ F +PP+N TLTF DTEIESHFQFH D +REINI+SVK+AL FDAIACQV STF++IS++ L+I+S GISK+T+L+Y+SG+ + +I+ WICLVYKSEIPS+I R IF+IF+HP+SRL IGIY+S PT LV+TLY+ K+Y+ YEYTV YFTL FF+LISNCIFT SYSV+KQMSTA CTA SLY+LL+P + YE SSC +FL++ ++ + QKL+YF+ FQL Q+CLL+Y+LT+ENEKNIRIFFYASREAEIRNDEARRERKVAE+FLYNIIPKYVFFQITGS D+KK+ KFSYA TI NAGVVFA I NFFSGYYRED+KRG +ALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLA+YNEENIVGNKHFYLKIGYNFGPVTAGIIGT+KPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF FEYRG VFMKGKGDVETYLA++PYE YMIYK GK +S+ E
Sbjct: 1 MFDHKIQKILKVMSLHSTAFSEYFHMLMTVHNVKSIRNGTKVIIIYFCSEIIVSHMGERSIIFGPIVALIAFCIFALIYILTANVDNSDTMISMASVMVVFCMTYSVILASDNEEMIEGRLSLMVANILMMFTLFHLRFLITLVLSIVYILIFMSAVNYRLKTDIP--HNLTRGHLRNSLNTLAVVRQEDHHIAHKYNLLVAECLLFFAVYLVGLYLRFFNSIRRKSAFLKLAQNAQAKMKMESAIEVQIYWIEAIMPSAVKTEFLQNVRHKDFFNLVYCRQFKDVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGNIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMIMTFNKVHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISEKTFKLVCHAYTFVEGEKLMIKKERKFGLEGFAQTLVPIPTYFVESVETEYDEYFNRINVNESKIYERYSEKLVESPVPETVIDKSSLAFKMRDEKMKNDLDLIRHLQSDPEKTVQFFHSPPINTFTLTFTDTEIESHFQFHSNDHLREINIDSVKIALLFDAIACQVYSTFILISSYVLVIKSSGISKSTSLMYLSGLIMTLISSWICLVYKSEIPSDIIRGIFIIFNHPVSRLFIGIYVSSFPTFLVYTLYNQTKMYDEYEYTVEYFTLIFFSLISNCIFTGSYSVIKQMSTAVCTATSLYILLKPKLDPIDYEISSCQEFLINILQYKIQKLQYFYGFQLLQVCLLIYYLTQENEKNIRIFFYASREAEIRNDEARRERKVAERFLYNIIPKYVFFQITGSTDEKKTNKFSYAHTIPNAGVVFACISNFFSGYYREDFKRGLNALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAHYNEENIVGNKHFYLKIGYNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFQFEYRGSVFMKGKGDVETYLAVKPYEKYMIYKLGKTRSFME 1049
BLAST of Adenylate cyclase type vs. Planmine SMEST
Match: SMESG000050971.1 (SMESG000050971.1) HSP 1 Score: 1657.11 bits (4290), Expect = 0.000e+0 Identity = 790/1024 (77.15%), Postives = 902/1024 (88.09%), Query Frame = 2
Query: 209 MTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITK-----FTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLLQPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIYKHGKAKSYSE 3265
MTVHN+KSIRNGTKV+I YFC EII SHM +R++I+ PIVALIAF +F + LT NV+ + TMIS+AS+MVV CM+YSVI+ +D +EM+E R SLMVA ILMM+TLFHLRFLIT++LSIVYILIF+SAVNYRL + HN+T+ + L VR +H I +KY +L+ + +LFF VYL GLYLR FNSIRRKSAFLKLAQNAQAKMKM+SAI+VQIYWIEAIMP+AV+ EFL+++R KD FNL YC+QFK+VSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFG IMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMI+ FN++HKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHIS+KTFKLVCHAYTF+EGEKLM+ KER+FGLEGFA TLVP+PTYFVES TE+DEYFNR ++ESK YER EK ES + IDKS+L FK+RDEKMKNDL+LIRHLQSDPE+TVQ F +PP+N TLTF DTEIESHFQFH D +REINI+SVK+AL FDAIACQV STF++IS++ L+I+S GISK+T+L+Y+SG+ + +I+ WICLVYKSEIPS+I R IF+IF+HP+SRL IGIY+S PT LV+TLY+ K+Y+ YEYTV YFTL FF+LISNCIFT SYSV+KQMSTA CTA SLY+LL+P + YE SSC +FL++ ++ + QKL+YF+ FQL Q+CLL+Y+LT+ENEKNIRIFFYASREAEIRNDEARRERKVAE+FLYNIIPKYVFFQITGS D+KK+ KFSYA TI NAGVVFA I NFFSGYYRED+KRG +ALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLA+YNEENIVGNKHFYLKIGYNFGPVTAGIIGT+KPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHF FEYRG VFMKGKGDVETYLA++PYE YMIYK GK +S+ E
Sbjct: 1 MTVHNVKSIRNGTKVIIIYFCSEIIVSHMGERSIIFGPIVALIAFCIFALIYILTANVDNSDTMISMASVMVVFCMTYSVILASDNEEMIEGRLSLMVANILMMFTLFHLRFLITLVLSIVYILIFMSAVNYRLKTDIP--HNLTRGHLRNSLNTLAVVRQEDHHIAHKYNLLVAECLLFFAVYLVGLYLRFFNSIRRKSAFLKLAQNAQAKMKMESAIEVQIYWIEAIMPSAVKTEFLQNVRHKDFFNLVYCRQFKDVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGNIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMIMTFNKVHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISEKTFKLVCHAYTFVEGEKLMIKKERKFGLEGFAQTLVPIPTYFVESVETEYDEYFNRINVNESKIYERYSEKLVESPVPETVIDKSSLAFKMRDEKMKNDLDLIRHLQSDPEKTVQFFHSPPINTFTLTFTDTEIESHFQFHSNDHLREINIDSVKIALLFDAIACQVYSTFILISSYVLVIKSSGISKSTSLMYLSGLIMTLISSWICLVYKSEIPSDIIRGIFIIFNHPVSRLFIGIYVSSFPTFLVYTLYNQTKMYDEYEYTVEYFTLIFFSLISNCIFTGSYSVIKQMSTAVCTATSLYILLKPKLDPIDYEISSCQEFLINILQYKIQKLQYFYGFQLLQVCLLIYYLTQENEKNIRIFFYASREAEIRNDEARRERKVAERFLYNIIPKYVFFQITGSTDEKKTNKFSYAHTIPNAGVVFACISNFFSGYYREDFKRGLNALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYREDHLYKLMLFSFDLLNQLAHYNEENIVGNKHFYLKIGYNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTAPAGKIQVSDYVHKYLATHFQFEYRGSVFMKGKGDVETYLAVKPYEKYMIYKLGKTRSFME 1022
BLAST of Adenylate cyclase type vs. Planmine SMEST
Match: SMESG000009035.1 (SMESG000009035.1) HSP 1 Score: 1156.35 bits (2990), Expect = 0.000e+0 Identity = 580/1041 (55.72%), Postives = 751/1041 (72.14%), Query Frame = 2
Query: 128 MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLL--QPTKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSA-DDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED-HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAP-AGKIQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYETYMIY 3235
ML+ K+E+V +V+SL S+ SEYFH LMT HNIKSIRNG KVLI Y CE++SSH+++R V+Y+PI+AL AF ++ F TV V+K+ TMI ASIMV++CM ++V +GTD E+ME +SL++ +ILMMYTLF ++F+I MLLS +YILIF+S N+R+ ++ + NI+ L+ +R I +KYY + GQ IL ++Y+TGLYLR FNSIRRKSAFLKLAQNA+A++KM SAIK+QIYWIEAIMP++V+ FL+ IR+ D+F+L YCK F+NVSILFADIVGFT MSSNKTA QLVYLLNDLYNRFD+ G+ NCEKI TLGDCYYCVSGCP+PR DHA+ CVEMGLGMC++I+ FN+ HKE VNMRVG+HSGRVIAAIIGN RFRFDV+S DV IAN+LESSG+ G VHIS+ T+ LV HAYTF +GE L + KE+ G+ G VP+ TYFV D+ N++ + S RN K +I DK+ FK +DEK K DL++++ LQ DPERTV+ FQNPP+N +TL FKD +IE + FH DQI I I S+K ALF D+IA V +T ++ +A+ +I ++ G + ++Y++G I+I +I L+YKSEI ++ RK++ FSHPL+RL + +YIS LP++ V +L+ E++ +NY Y Y +LT FALI N I T S+S++K ++TA T +YL++ + E + C + L + + ++K FFSFQLFQICLL+Y+L RENEKNIR+ FYA+REAEIRN EA K+AE LYNIIPK VF +I G FSYA NAGV+FA I NFFS YYREDYK GE AL++LH IIC FDNLL+ P+Y LEKIKT+NDCYM+ASGLN+ + D HL LM F+FD+ L +NE+NIVG FYLKIGYNFGP+TAGIIGTSKPLYDIWGDTVNVASRMYSTAP IQV +YV + L +F F+YRG + +KGKG++ TYL +R E +Y
Sbjct: 1 MLRLKLEEVSKVMSLRSSILSEYFHTLMTNHNIKSIRNGMKVLILYCYCEVVSSHISERGVLYRPILALFAFCIYFFIFASTVKVKKSVTMIRFASIMVIICMIHTVALGTDPMELMELNYSLIILIILMMYTLFRMKFMIVMLLSSMYILIFVSIGNFRIKYIDTADLNISA-APILQTIRGRRSGIVDKYYFVCGQCILLLLMYMTGLYLRFFNSIRRKSAFLKLAQNAEARLKMQSAIKIQIYWIEAIMPSSVKENFLKRIRNNDMFSLVYCKAFENVSILFADIVGFTMMSSNKTAAQLVYLLNDLYNRFDEQGRQTNCEKIGTLGDCYYCVSGCPIPRIDHAISCVEMGLGMCRLIVKFNKDHKENVNMRVGIHSGRVIAAIIGNHRFRFDVFSYDVIIANSLESSGRAGFVHISEDTYLLVRHAYTFEDGEILSIMKEQVHGISGMIQKSVPLRTYFVIP-----DKNKNKRKLQSRISLNRNTSNKLAEKSRKIFSDKAKNLFKKKDEKFKGDLKIVKCLQDDPERTVEFFQNPPINQITLAFKDPQIEYQYLFHTTDQIEPIQIYSIKAALFIDSIASMVYTTTILTAAYVMIPQNVGFKFYSPIIYVTGYIYIVIIAFISLMYKSEITNKTLRKVYSFFSHPLTRLYLSVYISSLPSIFVFSLFQNEQMQDNYHYITAYLSLTLFALIGNVISTSSFSLIKHITTAIFTICPIYLIVRTEAPHEHEFVGLEGCYEILEHFRNLLNVRIKCFFSFQLFQICLLVYYLARENEKNIRLNFYATREAEIRNAEATHANKIAESLLYNIIPKQVFKEIVGKKWSSSNEMAFSYAHAFANAGVIFACISNFFSSYYREDYKGGEVALRLLHTIICTFDNLLKKPIYLKLEKIKTINDCYMLASGLNSDHEEMASDEHLKILMTFAFDMHYHLRLFNEQNIVGTYTFYLKIGYNFGPITAGIIGTSKPLYDIWGDTVNVASRMYSTAPYCSSIQVPEYVVEKLKLYFDFKYRGTISVKGKGEMNTYLVVRSLEKPFLY 1035
BLAST of Adenylate cyclase type vs. Planmine SMEST
Match: SMESG000009036.1 (SMESG000009036.1) HSP 1 Score: 1098.19 bits (2839), Expect = 0.000e+0 Identity = 562/1040 (54.04%), Postives = 740/1040 (71.15%), Query Frame = 2
Query: 128 MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEIISSHMADRTVIYKPIVALIAFIVFVCFFGLTVNVEKTSTMISLASIMVVLCMSYSVIIGTDADEMMEARFSLMVAVILMMYTLFHLRFLITMLLSIVYILIFLSAVNYRLGLNESEEHNITKFTSALRKVRHSEHDIPNKYYMLIGQIILFFMVYLTGLYLRIFNSIRRKSAFLKLAQNAQAKMKMDSAIKVQIYWIEAIMPAAVRGEFLESIRSKDLFNLGYCKQFKNVSILFADIVGFTAMSSNKTAKQLVYLLNDLYNRFDDFGKIMNCEKIATLGDCYYCVSGCPVPRSDHALCCVEMGLGMCKMILAFNRLHKEEVNMRVGVHSGRVIAAIIGNLRFRFDVYSNDVSIANALESSGKPGKVHISKKTFKLVCHAYTFIEGEKLMVTKERQFGLEGFAPTLVPMPTYFVESYSTEFDEYFNRKVIDESKSYERNEEKSNESKPSQIGIDKSALEFKIRDEKMKNDLELIRHLQSDPERTVQCFQNPPLNPLTLTFKDTEIESHFQFHVVDQIREININSVKVALFFDAIACQVCSTFVIISAFFLIIESGGISKTTTLVYMSGIPLIMIAGWICLVYKSEIPSEIFRKIFVIFSHPLSRLSIGIYISVLPTLLVHTLYDAEKLYNNYEYTVGYFTLTFFALISNCIFTISYSVLKQMSTAACTAGSLYLLL-QP------TKEMDIYEYSSCVDFLVDYVEIQTQKLKYFFSFQLFQICLLLYFLTRENEKNIRIFFYASREAEIRNDEARRERKVAEKFLYNIIPKYVFFQITGSADDKKSTKFSYAKTIVNAGVVFASIGNFFSGYYREDYKRGESALKVLHNIICGFDNLLRLPLYKGLEKIKTVNDCYMMASGLNASSKAYRED-HLYKLMLFSFDLLNQLAYYNEENIVGNKHFYLKIGYNFGPVTAGIIGTSKPLYDIWGDTVNVASRMYSTAPAGK-IQVSDYVHKYLATHFLFEYRGKVFMKGKGDVETYLALRPYE 3220
ML+ K+ + ++ SL S S YF+ LMT HNIKSIRNG KVLI Y+ E++SSH+++R VI++PI+ALIAF +F + LT+ V+KT+TM +AS+MV+LCM+Y+VI+GTD E+ME +SL + +ILMMYTLF +FLIT+LLSIVYILIF+S NYRL E+ ++ +T+ L R + +I N + ++ Q LFF+ Y+TGLYLR FNSIRRKSAFLKLAQNAQA+MKM SAI+VQIYWIEAIMP++V+ +FL+ IR D+F+L YC+ F NVSILFADIVGFT MS+NKTA +LVYLLNDLYNRFD G+ NCEKI TLGDCYYCVSGCP+PR DHA+ CVEMGLGMC++I+ FN+ HKE+VNMRVG+HSGRVIAAIIGN RFRFDV+SNDV IAN+LESSGKPG VHIS+ T+ LV HAY EGE L + KE G+ G +VPM TYFV S + + + + + S ++K I D A +K +D K+K DL++++ LQ DPER+++ F+NPP++ + TFKD EIE + +H DQI + I+++KVA F D++A V +T +++ + +I + + L+Y SG IA +I YKS+I + + R I+ +SHPLSRL + +YIS LP+LLV + +D E L+ +Y++ + Y +LT FALI N I T S S++K ++T + + L++ QP +EM + +C D + + V+ +++ F+FQL +CL++Y+LTRENEK RI FYA+REA+IRN EA R +++AE LYNIIPK+VF I+ +K F+YA NAGVVFA I NFFS YYREDYK GE ALK+LH IIC FDNLL P Y LEKIKT+NDCYM+ASG+N S +ED HL LM F+ D+ L +NE+NIVG FYLKIG+NFGPVTAGIIGT+KPLYDIWGDTVNVASRMYST+P+G IQV DYV L F F+YRG V +KGKG++ TYL +R Y+
Sbjct: 1 MLRAKIANLRKITSLRSAILSAYFYTLMTNHNIKSIRNGMKVLIIYWYFEVVSSHISERGVIFRPILALIAFCIFFLIYVLTIRVQKTNTMTRMASLMVILCMTYTVILGTDILEIMEIHYSLSLLIILMMYTLFRFKFLITVLLSIVYILIFVSIGNYRLKFVENINMSVF-YTTPLEISRAMKIEIKNHHSFIVAQCGLFFLAYITGLYLRCFNSIRRKSAFLKLAQNAQARMKMQSAIQVQIYWIEAIMPSSVKEQFLKRIRDNDMFSLVYCQNFDNVSILFADIVGFTKMSANKTAAKLVYLLNDLYNRFDVQGRQTNCEKIGTLGDCYYCVSGCPIPRIDHAINCVEMGLGMCRIIMKFNKDHKEKVNMRVGIHSGRVIAAIIGNHRFRFDVFSNDVVIANSLESSGKPGLVHISEDTYVLVRHAYAVNEGEALEIKKEEVHGISGMMQKIVPMSTYFVIPDSVPYKLKIKDRAVHDFNVSNTTIKISKDTKKLLIK-DAKAESYKRKDAKLKEDLKIVQMLQEDPERSIEFFKNPPIHNFSQTFKDREIEYQYLYHTTDQIEPLKIDTIKVATFIDSVASLVYATIILLISLLMIPNNVRFKLYSPLIYASGFVFTFIAAYISFFYKSQIRNPVARLIYAFWSHPLSRLFLSVYISSLPSLLVLSFFDKEVLHGHYQFMIAYLSLTIFALIGNTICTASVSLIKHITTLSFAMVPIILVVFQPFEIDSSKEEMSL----NCSDLIKNKVDFSKVRMQCNFTFQLLSVCLVIYYLTRENEKTTRINFYATREADIRNAEAIRAKRIAESLLYNIIPKHVFADISARKTQEKEMSFTYAHAFANAGVVFACISNFFSSYYREDYKGGEVALKLLHTIICTFDNLLHKPAYSLLEKIKTINDCYMIASGINVDSSLLKEDEHLIALMTFALDMHYHLKLFNEQNIVGKNTFYLKIGFNFGPVTAGIIGTTKPLYDIWGDTVNVASRMYSTSPSGSTIQVPDYVCVRLKDSFQFKYRGVVSVKGKGEMITYLVIRSYD 1034 The following BLAST results are available for this feature:
BLAST of Adenylate cyclase type vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Adenylate cyclase type vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Adenylate cyclase type vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Adenylate cyclase type vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Adenylate cyclase type vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30001170 ID=SMED30001170|Name=Adenylate cyclase type|organism=Schmidtea mediterranea sexual|type=transcript|length=3372bpback to top protein sequence of SMED30001170-orf-1 >SMED30001170-orf-1 ID=SMED30001170-orf-1|Name=SMED30001170-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1051bp MLKQKVEKVLRVLSLNSTAFSEYFHMLMTVHNIKSIRNGTKVLIFYFCCEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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