Mcm10 domain-containing protein

Overview
NameMcm10 domain-containing protein
Smed IDSMED30001057
Length (bp)2174
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mcm10 domain-containing protein (SMED30001057) t-SNE clustered cells

Violin plots show distribution of expression levels for Mcm10 domain-containing protein (SMED30001057) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mcm10 domain-containing protein (SMED30001057) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mcm10 domain-containing protein (SMED30001057) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30001057

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30001057h1SMcG0019618 SmedASXL_012211SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30001057h1SMcG0019618 SmedASXL_012211SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
cephalic gangliaSMED30001057h1SMcG0019618 dd_Smed_v4_11868_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30001057h1SMcG0019618 dd_Smed_v4_11868_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30001057h1SMcG0019618 dd_Smed_v4_16334_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30001057h1SMcG0019618 dd_Smed_v6_11868_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30001057h1SMcG0019618 dd_Smed_v6_16334_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
body wall musculatureSMED30001057h1SMcG0019618 dd_Smed_v4_16334_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30001057h1SMcG0019618 dd_Smed_v4_11868_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30001057h1SMcG0019618 dd_Smed_v4_16334_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30001057h1SMcG0019618 SMED_28579_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30001057h1SMcG0019618 SMED_28579_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Human
Match: MCM10 (minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043])

HSP 1 Score: 128.642 bits (322), Expect = 5.939e-30
Identity = 57/170 (33.53%), Postives = 97/170 (57.06%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +   ++ L + DW+  GVI++    +  N+   FSIW LNDL+ L + V + LF +V++  WK   GTVV IL    +   +  +    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YHVQ+ Y K
Sbjct:  252 LRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKK 421

HSP 2 Score: 65.4698 bits (158), Expect = 3.024e-10
Identity = 45/148 (30.41%), Postives = 74/148 (50.00%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  +++ E  A+  E+  + +   E+ E K+    E +C V  C  C     +  + CV+E H      G +R+FKC  C  R+ + D+ P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  727 SEEFQKILKAKSKHTGILK-EAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKC-PCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 872
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Human
Match: MCM10 (minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043])

HSP 1 Score: 128.642 bits (322), Expect = 6.107e-30
Identity = 57/170 (33.53%), Postives = 97/170 (57.06%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +   ++ L + DW+  GVI++    +  N+   FSIW LNDL+ L + V + LF +V++  WK   GTVV IL    +   +  +    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YHVQ+ Y K
Sbjct:  253 LRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKK 422

HSP 2 Score: 65.4698 bits (158), Expect = 2.924e-10
Identity = 45/148 (30.41%), Postives = 74/148 (50.00%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  +++ E  A+  E+  + +   E+ E K+    E +C V  C  C     +  + CV+E H      G +R+FKC  C  R+ + D+ P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  728 SEEFQKILKAKSKHTGILK-EAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKC-PCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 873
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Human
Match: MCM10 (minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043])

HSP 1 Score: 128.257 bits (321), Expect = 7.901e-30
Identity = 57/170 (33.53%), Postives = 97/170 (57.06%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +   ++ L + DW+  GVI++    +  N+   FSIW LNDL+ L + V + LF +V++  WK   GTVV IL    +   +  +    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YHVQ+ Y K
Sbjct:  252 LRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKK 421

HSP 2 Score: 57.3806 bits (137), Expect = 8.961e-8
Identity = 37/123 (30.08%), Postives = 60/123 (48.78%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMK 2065
            SEE  K+L   S +  +++ E  A+  E+  + +   E+ E K+    E +C V  C  C     +  + CV+E H      G +R+FKC  C  R+ + D+ P+  C  CG   +ER G +K
Sbjct:  727 SEEFQKILKAKSKHTGILK-EAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKC-PCGNRSISLDRLPNKHCSNCGLYKWERDGMLK 847
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Celegans
Match: mcm-10 (Yeast MCM (Licensing factor) related [Source:UniProtKB/TrEMBL;Acc:Q9U2C2])

HSP 1 Score: 82.4185 bits (202), Expect = 5.202e-16
Identity = 54/193 (27.98%), Postives = 98/193 (50.78%), Query Frame = 2 
Query:  455 KIRVYNPQVTSDNWKDRISGRQV-----LTPHKLCQGNMKDSLSDTDWILVGVIVQAACKK-DKNNNNFSIWHLNDLQ-CLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQ------ILVLGRSPDFGICQG-KSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVN 991
            +I + NP++++ ++    +G ++     L P      N K++     W  +GVIV+   KK   N N+F IW L+DL+ C  + VK+++F    +  W+   G+V+A++  + +  +     +  TV   L+      I+ +G+S  FG C+G + + G+ C+N VN S    C +HV S   K  ++ G  N
Sbjct:  126 QISIRNPKISATSFGAFTAGMKLEKLSNLKP----TSNFKEA-----WCTIGVIVEKGFKKKSANGNDFLIWKLHDLKDCQTQPVKLLMFGDAIKDHWEIKLGSVIALISAQ-IADDSTASGAKKTVSATLKVAKSNNIVEIGQSAHFGTCKGIRQQDGQRCSNFVNSSLSEFCVFHVMSAARKLSAKRGVFN 308

HSP 2 Score: 62.003 bits (149), Expect = 1.060e-9
Identity = 47/162 (29.01%), Postives = 75/162 (46.30%), Query Frame = 2 
Query: 1658 TADSLDNKAKKPALS--EEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECV-VFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVA--SETLKVHGNEKRFINN 2128
            T  + + +AKKP     +E+  +L++ S++ K  E  +       L  ME  EK ET  TT  E + V V  C QC+  +      C+ + H +      +R+FKC  C  RT  ++  P   C  C    +ER     ER+V   +E L + G E+ F+ +
Sbjct:  530 TPTAPEPEAKKPRSQKMDEIRAMLARKSTHHKEAEKAEHDMLQRHLTGMEEREKVETFTTTCVEVKNVKVVTCNQCKYTSQFASSECIKKEHKLIKHTADKRFFKCTGCKKRTVCFEMMPVKHCAHCNENKWERVAMKDERKVVLDTENLLLRGEERPFVGS 691
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Fly
Match: Mcm10 (gene:FBgn0032929 transcript:FBtr0081475)

HSP 1 Score: 108.612 bits (270), Expect = 4.521e-24
Identity = 53/175 (30.29%), Postives = 97/175 (55.43%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIV-QAACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSA-FTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISR 976
            +R+ NP V+S   ++R++GR+ + P      +++      DW++ G +V +   K  K  + +S W L+DL+   K + + LF++ ++  WK A G  +A+L P            A  ++D++ ++++LG+S D G C+   K+G+ CT+VVN +DC  C +HV+  Y K   R
Sbjct:  194 LRMINPLVSSSLLQERMTGRKPV-PFSGVAYHIERGDLAKDWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKMSRR 367

HSP 2 Score: 82.4185 bits (202), Expect = 7.805e-16
Identity = 51/172 (29.65%), Postives = 86/172 (50.00%), Query Frame = 2 
Query: 1652 RRTADSLDNK----AKKPALSEE---------MLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVAS--ETLKVHGNEKRFI 2122
            RR  D L+ K    AK+  + E+         + K+++  SS+  LVE+ +    +E  +K+E  E  E K+ T ++  C   IC  C+         C  + H +K +   +R+F+C  C  RTTT  K P  SC  C    ++RT  ++E+++ +  ETL V G+E+ F+
Sbjct:  588 RRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFM 759
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Zebrafish
Match: mcm10 (minichromosome maintenance 10 replication initiation factor [Source:NCBI gene;Acc:553396])

HSP 1 Score: 137.502 bits (345), Expect = 4.980e-33
Identity = 64/182 (35.16%), Postives = 104/182 (57.14%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF 1000
            +R+  P+++S + + +++ R+++   +L     +D+L D+DW+   VI+     + KNN   FSIW LNDL  L+  V + LF  V+   WK  TGTV+ IL P  +   E     + TVD   ++L++G + DFG C+ K K+G+SCT +VN  +C  C YHV++ Y K  S+   +   F
Sbjct:  224 LRLRKPRLSSIDIEQKMASRKLIRLSQLPDRLARDNLEDSDWVTFAVIINKITPQSKNNGKTFSIWKLNDLHNLEVNVSLFLFGSVHTDLWKTDTGTVIGILNPNPMKNKEGSNELSLTVDHPQKVLIIGEAMDFGTCKAKKKNGDSCTQLVNLYECQFCQYHVKAQYKKMSSKRAELQSSF 405

HSP 2 Score: 67.0106 bits (162), Expect = 5.435e-11
Identity = 45/148 (30.41%), Postives = 72/148 (48.65%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLV-EVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  ++L+  SSN  ++ E+E+ A   E  + +   EK E K+ +  E +C    C  C+    +    CV E H        +R+FKC  C  R     + P G+C  CG   +ER G +KE+   ++  E L   G E+ +F+N+
Sbjct:  686 SEEFQRILNAKSSNSWMMGEIEERA-MQEYFEPLVQKEKMEEKMKSIREMKCRAVTCKTCKYTHFKPADRCVEEKHDYHWHDAVKRFFKC-PCGQRKICLARMPHGACSHCGLFKWERDGMLKEKKGPKIGGELLMPRGEEQPKFLNS 831
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Match: phax (phosphorylated adaptor for RNA export [Source:Xenbase;Acc:XB-GENE-493560])

HSP 1 Score: 187.963 bits (476), Expect = 1.759e-49
Identity = 176/666 (26.43%), Postives = 291/666 (43.69%), Query Frame = 2 
Query:  350 TKMVMPGDIIHKNDLPAPEKQPVKN------SSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVK------LLRKPTAGTKNLVKHIV-------EKSIGP-EAI-GSNIVKQN-----------------RIFDDTPAT-------AAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLG--------YKPVKLDQVSAEVYR-AELNKLRIAAQ--AKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPAL-----------SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            T  + P D      + +   QPV N        +Y + + + +R+  P+V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  + +G + G   S      L  +    +  +  L +    G  A  + A  +++A   +MV+      L+  PT G  NL KH         EK   P ++I  S ++KQ                  R  + T  +       +++   F+S KQ   E   AQ       G+    G          P      SA+  + A + KL+   Q   K        K S+  E L    V +   A +      +PA+           S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  189 TSFLSPPDKSSTRPVSSTATQPVLNPVRSPVGQQYPVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQ-DGFHYGGVSSMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQQIAAARKNMVQSDEFKELMTLPTPGALNLKKHFSGVPTQANEKGGQPFQSISASALLKQQKQQMLGARKKRAEEIQKRFLESTEKSEKSSTLVSSERSVFQSPKQG-AEFPNAQKMATPKLGRGFAEGEDVLFFDISPPAAKSNTSAQATKLAAIQKLQAKGQTLTKADPNSIKRKRSSSAEELVAQRVASHAPASTKSPDENEPAMKKHREQLAYLESKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 844
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Match: phax (phosphorylated adaptor for RNA export [Source:Xenbase;Acc:XB-GENE-493560])

HSP 1 Score: 184.882 bits (468), Expect = 1.603e-48
Identity = 163/634 (25.71%), Postives = 278/634 (43.85%), Query Frame = 2 
Query:  350 TKMVMPGDIIHKNDLPAPEKQPVKN------SSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQNRIFDDTPAT-------AAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLG--------YKPVKLDQVSAEVYR-AELNKLRIAAQ--AKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPAL-----------SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            T  + P D      + +   QPV N        +Y + + + +R+  P+V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  +    Y G S        +  +   A  T      +++  NM    A  + + A+ + +       +     L+K   ++ +G     +  + Q R  + T  +       +++   F+S KQ   E   AQ       G+    G          P      SA+  + A + KL+   Q   K        K S+  E L    V +   A +      +PA+           S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  188 TSFLSPPDKSSTRPVSSTATQPVLNPVRSPVGQQYPVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQDGFHYGGVS-------SMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQLVLYPF---QSISASALLKQQKQQMLGARKKRAEEI-QKRFLESTEKSEKSSTLVSSERSVFQSPKQG-AEFPNAQKMATPKLGRGFAEGEDVLFFDISPPAAKSNTSAQATKLAAIQKLQAKGQTLTKADPNSIKRKRSSSAEELVAQRVASHAPASTKSPDENEPAMKKHREQLAYLESKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 801
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Match: phax (phosphorylated adaptor for RNA export [Source:Xenbase;Acc:XB-GENE-493560])

HSP 1 Score: 144.05 bits (362), Expect = 5.572e-35
Identity = 168/666 (25.23%), Postives = 274/666 (41.14%), Query Frame = 2 
Query:  350 TKMVMPGDIIHKNDLPAPEKQPVKN------SSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVK------LLRKPTAGTKNLVKHIV-------EKSIGP-EAI-GSNIVKQN-----------------RIFDDTPAT-------AAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLG--------YKPVKLDQVSAEVYR-AELNKLRIAAQ--AKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPAL-----------SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            T  + P D      + +   QPV N        +Y + + + +R+  P+V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E                  G      +C   S    +CT     +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  + +G + G   S      L  +    +  +  L +    G  A  + A  +++A   +MV+      L+  PT G  NL KH         EK   P ++I  S ++KQ                  R  + T  +       +++   F+S KQ   E   AQ       G+    G          P      SA+  + A + KL+   Q   K        K S+  E L    V +   A +      +PA+           S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  189 TSFLSPPDKSSTRPVSSTATQPVLNPVRSPVGQQYPVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKE------------------GTDEVRAVC---SNVWTACT---KSNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQ-DGFHYGGVSSMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQQIAAARKNMVQSDEFKELMTLPTPGALNLKKHFSGVPTQANEKGGQPFQSISASALLKQQKQQMLGARKKRAEEIQKRFLESTEKSEKSSTLVSSERSVFQSPKQG-AEFPNAQKMATPKLGRGFAEGEDVLFFDISPPAAKSNTSAQATKLAAIQKLQAKGQTLTKADPNSIKRKRSSSAEELVAQRVASHAPASTKSPDENEPAMKKHREQLAYLESKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 820
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Match: phax (phosphorylated adaptor for RNA export [Source:Xenbase;Acc:XB-GENE-493560])

HSP 1 Score: 140.584 bits (353), Expect = 2.975e-34
Identity = 93/333 (27.93%), Postives = 157/333 (47.15%), Query Frame = 2 
Query:  350 TKMVMPGDIIHKNDLPAPEKQPVKN------SSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVK------LLRKPTAGTKNLVKHI 1309
            T  + P D      + +   QPV N        +Y + + + +R+  P+V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  +    Y G S        +  +   A  T      +++  NM    A  + + A+  +MV+      L+  PT G  NL KH 
Sbjct:    2 TSFLSPPDKSSTRPVSSTATQPVLNPVRSPVGQQYPVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQDGFHYGGVS-------SMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQKNMVQSDEFKELMTLPTPGALNLKKHF 321

HSP 2 Score: 77.411 bits (189), Expect = 4.120e-14
Identity = 49/148 (33.11%), Postives = 78/148 (52.70%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  502 SKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 647
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Match: phax (phosphorylated adaptor for RNA export [Source:Xenbase;Acc:XB-GENE-493560])

HSP 1 Score: 132.494 bits (332), Expect = 2.377e-31
Identity = 82/287 (28.57%), Postives = 141/287 (49.13%), Query Frame = 2 
Query:  464 VYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDV----SMVKLLRKPTAGTKNLVKHI 1309
            +Y  +V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  + +G + G   S      L  +    +  +  L +    G  A  + A  +++ K++       +L+  PT G  NL KH 
Sbjct:  159 IYKNKVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQ-DGFHYGGVSSMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQQIARKNMVQSDEFKELMTLPTPGALNLKKHF 438

HSP 2 Score: 76.6406 bits (187), Expect = 8.501e-14
Identity = 49/148 (33.11%), Postives = 78/148 (52.70%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  624 SKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 769
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Mouse
Match: Mcm10 (minichromosome maintenance 10 replication initiation factor [Source:MGI Symbol;Acc:MGI:1917274])

HSP 1 Score: 126.716 bits (317), Expect = 1.661e-29
Identity = 55/170 (32.35%), Postives = 95/170 (55.88%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNN-NNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +    ++L +TDW+  GVI++    +   +   FSIW LNDL  L + V + LF  V++  WK   GTV+ +L    +   +  K    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YH+Q+ Y K
Sbjct:  269 LRLRRPRVSSTEMSRKMAGRKLIRLPQIKEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKTEQGTVIGLLNANPMKPKDGLKEVCLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDCEYCQYHIQAQYKK 438

HSP 2 Score: 70.8626 bits (172), Expect = 4.342e-12
Identity = 49/150 (32.67%), Postives = 73/150 (48.67%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLV---EVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  ++   E E    + E L K E   + E K+    E +C V  C  C     +  + CV+E H +    G +R+FKC  C  RT + DK P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  738 SEEFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKE---QMEEKMRATREVKCRVVTCRTCTYTHFKPLETCVSEQHNLHWHDGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 883
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Mouse
Match: Mcm10 (minichromosome maintenance 10 replication initiation factor [Source:MGI Symbol;Acc:MGI:1917274])

HSP 1 Score: 126.716 bits (317), Expect = 1.661e-29
Identity = 55/170 (32.35%), Postives = 95/170 (55.88%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNN-NNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +    ++L +TDW+  GVI++    +   +   FSIW LNDL  L + V + LF  V++  WK   GTV+ +L    +   +  K    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YH+Q+ Y K
Sbjct:  269 LRLRRPRVSSTEMSRKMAGRKLIRLPQIKEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKTEQGTVIGLLNANPMKPKDGLKEVCLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDCEYCQYHIQAQYKK 438

HSP 2 Score: 70.8626 bits (172), Expect = 4.342e-12
Identity = 49/150 (32.67%), Postives = 73/150 (48.67%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLV---EVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  ++   E E    + E L K E   + E K+    E +C V  C  C     +  + CV+E H +    G +R+FKC  C  RT + DK P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  738 SEEFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKE---QMEEKMRATREVKCRVVTCRTCTYTHFKPLETCVSEQHNLHWHDGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 883
[Close]
BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q28E45|MCM10_XENTR (Protein MCM10 homolog OS=Xenopus tropicalis OX=8364 GN=mcm10 PE=2 SV=1)

HSP 1 Score: 187.963 bits (476), Expect = 9.319e-49
Identity = 176/666 (26.43%), Postives = 291/666 (43.69%), Query Frame = 2 
Query:  350 TKMVMPGDIIHKNDLPAPEKQPVKN------SSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVK------LLRKPTAGTKNLVKHIV-------EKSIGP-EAI-GSNIVKQN-----------------RIFDDTPAT-------AAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLG--------YKPVKLDQVSAEVYR-AELNKLRIAAQ--AKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPAL-----------SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            T  + P D      + +   QPV N        +Y + + + +R+  P+V+S   + +++GR+++   +L    + + L D DW+  GVIV+    +  NN   FSIW LNDL+ LDK V + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K +  G  +      RE+  + +G + G   S      L  +    +  +  L +    G  A  + A  +++A   +MV+      L+  PT G  NL KH         EK   P ++I  S ++KQ                  R  + T  +       +++   F+S KQ   E   AQ       G+    G          P      SA+  + A + KL+   Q   K        K S+  E L    V +   A +      +PA+           S+E  K+L+  S +  +++ E  A+  E+  D +   E+ E K+ +  EQEC V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++A ETL   G E  +F+N+
Sbjct:  189 TSFLSPPDKSSTRPVSSTATQPVLNPVRSPVGQQYPVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGGNGL------RERLCQ-DGFHYGGVSSMAYATTLASTTAPKKTVQSTLSNMVVRGAEAIALEARQQIAAARKNMVQSDEFKELMTLPTPGALNLKKHFSGVPTQANEKGGQPFQSISASALLKQQKQQMLGARKKRAEEIQKRFLESTEKSEKSSTLVSSERSVFQSPKQG-AEFPNAQKMATPKLGRGFAEGEDVLFFDISPPAAKSNTSAQATKLAAIQKLQAKGQTLTKADPNSIKRKRSSSAEELVAQRVASHAPASTKSPDENEPAMKKHREQLAYLESKEFQKILNAKSKHTGILK-EAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEKTGPKIAGETLLPRGEEHGKFLNS 844
[Close]
BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5RHY1|MCM10_DANRE (Protein MCM10 homolog OS=Danio rerio OX=7955 GN=mcm10 PE=3 SV=1)

HSP 1 Score: 137.502 bits (345), Expect = 3.759e-32
Identity = 64/182 (35.16%), Postives = 104/182 (57.14%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF 1000
            +R+  P+++S + + +++ R+++   +L     +D+L D+DW+   VI+     + KNN   FSIW LNDL  L+  V + LF  V+   WK  TGTV+ IL P  +   E     + TVD   ++L++G + DFG C+ K K+G+SCT +VN  +C  C YHV++ Y K  S+   +   F
Sbjct:  224 LRLRKPRLSSIDIEQKMASRKLIRLSQLPDRLARDNLEDSDWVTFAVIINKITPQSKNNGKTFSIWKLNDLHNLEVNVSLFLFGSVHTDLWKTDTGTVIGILNPNPMKNKEGSNELSLTVDHPQKVLIIGEAMDFGTCKAKKKNGDSCTQLVNLYECQFCQYHVKAQYKKMSSKRAELQSSF 405

HSP 2 Score: 67.0106 bits (162), Expect = 4.103e-10
Identity = 45/148 (30.41%), Postives = 72/148 (48.65%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLV-EVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  ++L+  SSN  ++ E+E+ A   E  + +   EK E K+ +  E +C    C  C+    +    CV E H        +R+FKC  C  R     + P G+C  CG   +ER G +KE+   ++  E L   G E+ +F+N+
Sbjct:  686 SEEFQRILNAKSSNSWMMGEIEERA-MQEYFEPLVQKEKMEEKMKSIREMKCRAVTCKTCKYTHFKPADRCVEEKHDYHWHDAVKRFFKC-PCGQRKICLARMPHGACSHCGLFKWERDGMLKEKKGPKIGGELLMPRGEEQPKFLNS 831
[Close]
BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5EAW4|MCM10_XENLA (Protein MCM10 homolog OS=Xenopus laevis OX=8355 GN=mcm10 PE=1 SV=2)

HSP 1 Score: 136.346 bits (342), Expect = 8.655e-32
Identity = 93/323 (28.79%), Postives = 158/323 (48.92%), Query Frame = 2 
Query:  410 QPVKNSSK------YFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERK--RSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKM-SAKDVSMV----KLLRKPTAGTKNLVKHIVEKSIGPEA 1336
            QP+ N+ K      Y + + + +R+  P+V+S   + +++GR+++   +L      + L + DW+  GVIV+    +  NN   FSIW LNDL+ LDK + + LF  V+++ WK   GTV+ +L    +   E       +VD   ++L++G + D G C+ + K+G+ CT +VN +DC  C YHVQ+ Y K  S+   +   +     +K  R A G+        RE+  +    Y G S    +   L  +    +  +  L +    G  A  + A  K+ +AK+V       +L+  PT G  NL KH+    + P+A
Sbjct:  222 QPITNTLKSPVGQQYHVEKFSGLRIRKPRVSSSEMERKMNGRKLIRLAQLQNKIATEKLEEEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKDLDKYISLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGANGL--------RERLCQGGFHYGGVSSMAYAA-TLGSTTAPKKTVQSTLSNMVVRGAEAIALEARQKIAAAKNVVQTDEFKELMTLPTPGALNLKKHL--SGVSPQA 533

HSP 2 Score: 74.7146 bits (182), Expect = 1.873e-12
Identity = 45/147 (30.61%), Postives = 74/147 (50.34%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L+  S +  +++  ++   +   D +   E+ E K+ +  EQ C V  C  C+    +  + CV+E H      G +R+FKC  C  RT + D+ P   C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  713 SEEFQKILNAKSKHTGILKEAEVEIQEHYFDPLVKKEQLEEKMQSIREQSCRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKC-PCGNRTISLDRLPKKHCSTCGLFKWERVGMLKEKTGPKLGGETLLPRGEEHGKFLNS 858
[Close]
BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7L590|MCM10_HUMAN (Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2)

HSP 1 Score: 128.642 bits (322), Expect = 2.933e-29
Identity = 57/170 (33.53%), Postives = 97/170 (57.06%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +   ++ L + DW+  GVI++    +  N+   FSIW LNDL+ L + V + LF +V++  WK   GTVV IL    +   +  +    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YHVQ+ Y K
Sbjct:  253 LRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKK 422

HSP 2 Score: 65.4698 bits (158), Expect = 1.404e-9
Identity = 45/148 (30.41%), Postives = 74/148 (50.00%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEK-LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  +++ E  A+  E+  + +   E+ E K+    E +C V  C  C     +  + CV+E H      G +R+FKC  C  R+ + D+ P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  728 SEEFQKILKAKSKHTGILK-EAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKC-PCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 873
[Close]
BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0VBD2|MCM10_MOUSE (Protein MCM10 homolog OS=Mus musculus OX=10090 GN=Mcm10 PE=1 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 1.162e-28
Identity = 55/170 (32.35%), Postives = 95/170 (55.88%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNN-NNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            +R+  P+V+S     +++GR+++   ++ +    ++L +TDW+  GVI++    +   +   FSIW LNDL  L + V + LF  V++  WK   GTV+ +L    +   +  K    ++D   ++L++G + D G C+ K K+GE CT  VN  DC  C YH+Q+ Y K
Sbjct:  269 LRLRRPRVSSTEMSRKMAGRKLIRLPQIKEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKTEQGTVIGLLNANPMKPKDGLKEVCLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDCEYCQYHIQAQYKK 438

HSP 2 Score: 70.8626 bits (172), Expect = 3.037e-11
Identity = 49/150 (32.67%), Postives = 73/150 (48.67%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLV---EVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L   S +  ++   E E    + E L K E   + E K+    E +C V  C  C     +  + CV+E H +    G +R+FKC  C  RT + DK P+  C  CG   +ER G +KE+   ++  ETL   G E  +F+N+
Sbjct:  738 SEEFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKE---QMEEKMRATREVKCRVVTCRTCTYTHFKPLETCVSEQHNLHWHDGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNS 883
[Close]
BLAST of Mcm10 domain-containing protein vs. TrEMBL
Match: A0A564YG19 (Mcm10 domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6106 PE=4 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 1.986e-67
Identity = 181/652 (27.76%), Postives = 310/652 (47.55%), Query Frame = 2 
Query:  434 YFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQ---GNMKDSLSDTDWILVGVI-VQAACKKDKNNNNFSIWHLNDLQCLDKA------VKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSS-------AFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAI-SRPGFVNLGFERLNERKRSAAGMAMP-------------------PLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHI--VEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESFKQKRMESIAAQNAPVASTGQS---IDLGYKPVKLDQVSAEVYRA--------ELNKLRIAAQAKEMGGYAAMKESNRQEHLRKI-----------------------AVPNRRTADSLDNKA-----KKPALS-------EEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEKRFIN 2125
            YF+A PT IRV  PQ++S+ W+ R S R+V +  +  +   G    +L     +LV ++  +   ++ +NN  FSIW L DL  +         V + LF   +E+ WK   GTV+AIL+PK LP +EN K +       + TVD+A  +++LG SPD   C G +K+G  C+ +VNK+ C  C +HV+S Y  A  +R GF      +    +  AA M++                    P   +R+  P  +G+   +SR  +++ KL  +G    ++   L   +++ N++ +++ P      + + V  L +P+ G+ NL++H+    KS G   +G+   ++  I   +P       TF +F  K  + +A Q  P    G     +DLG  PV +   ++ + ++        +  + R  +  K  GG   M ++++++  ++I                       A  ++   D +  K      K P+         EE++KL+SQGS + +L    +       L ++E  ++ E KL  QHEQEC V  C+ CQ ++ R  K C  EGH ++   G RR+F C KC TRT T D+YP+  C+ CG   +E+   + +R   ++  E L + G E++F++
Sbjct:  180 YFVATPTNIRVVQPQISSEIWETRTSNRRVFSLIQYAREASGPNATNLQTETTVLVAIVGSKMPPRRSRNNKIFSIWRLTDLTTVGTGSLTGPNVSLFLFGACHEKLWKHPEGTVIAILKPKILPPSENDKYAGNGLVNVSITVDSAPFVMLLGMSPDLAHCAGTTKAGNPCSRIVNKNACKYCDFHVKSAYISASQNRAGFATRSISKPEIGQGRAAYMSLNASSAVTSQSGFSLQHPLTMPTSCSRDIGP--QGQNVKSSRVSLNISKLSSAGYKIDSSTVTLTTASNNPNVSTSLSKP------EEAFVSSLARPSRGSLNLLRHLEDAHKS-GSGPLGT--ARRPSIISVSPIKPKSDETFATFF-KGAKKLATQPKPQLGRGLQGTFVDLG--PVSIQPGASALLQSLPSFPSPLDAARQRAVSLVKARGGIYGMLQADKEKTRKRISEVIEKSMAKKARPSPLDQILGSASSSKENLDPVPQKTPEVSQKGPSFCERIKKKREELVKLVSQGSGHSELAVANEDNASKRMLCRLEARDQIEEKLLNQHEQECQVVTCLDCQYRSMRVGKNCRKEGHKLEFSTGIRRFFACRKCKTRTVTLDRYPNFECINCGESLFEKDYAIAKRKGPKLVGEKLVIRGIEEKFLS 817
[Close]
BLAST of Mcm10 domain-containing protein vs. TrEMBL
Match: A0A4S2LJT0 (Mcm10 domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008087 PE=4 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 2.049e-63
Identity = 193/680 (28.38%), Postives = 312/680 (45.88%), Query Frame = 2 
Query:  404 EKQPVKNSSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQV-----LTPHKLCQGNM------KDSLSDTDWILVGVI-VQAACKKDKNNNNFSIWHLNDLQCLDKA-----VKVMLFRQVYEQFWKEATGTVVAILQPKSLP---TNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKA-ISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKME--GKYA--------------GNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPV---KMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQN-------------------RIFDDTPATAAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEH-------LRKIAVPNRRT---ADSLDNKAKKPALSE-------------------------------EMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEK---FETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQ---VASETLKVHGNEKRFIN 2125
            +K  V ++  Y++A PTK+RVY  +++S+ W +R S RQV        H+  Q  +      + + +DT  ++VGVI  +A  ++ KN+  +S+WHL+DL  +        VK+ LF   +E+ WKE  G+VVAIL P+ +    T+ N K    T  +   ++VLG+S D+GIC   +KSG+SC +V+NKS C  C  HV+  Y++A  SRPGF +     L +R          P    ++  P +   G Y+                SR  +++ KL  +G T  ++  GL  +    +  G  + P     +S+ +  ++K L +PTAG+ NL++H+ E+S    A+ +  V                      R   D       GFTF  F   R +  A +       G  IDLG  P     +S  +  A   +LR +   K  GG  AM+   +Q         L + +V   R    +  LDN +  P+ +E                               E+ K + +GSS+  L+     A+ + +  +M V+EK   FE KLT + E++C    C  C  +  +    C    H+V  +KG +RYFKC  C  RT T+++YP  +C  CG   +E+TG ++ER+   +  E L   G E++F++
Sbjct:  257 KKSVVSSAPDYWLAVPTKLRVYRSKISSELWANRTSDRQVYGLLQFIQHQRSQVTLSMPSSKRQNSTDT-LVVVGVIGSKAPPRRSKNDRIYSVWHLSDLDQVGPGSHIGCVKLFLFGNAHEKLWKEPDGSVVAILGPRLMSDPSTSFNDKDVGITPPSPQHVMVLGQSLDYGICTALNKSGQSCFHVINKSVCRYCDLHVKKAYYEASSSRPGFFDSSHPALKKR----------PTNRYKDDGPSVNEPGVYSLPTSKIFNPVSPSRSESRVKLTVAKLSAAGYTVDSST-GLATQQHGADFTGYPSRPPPVQPLSSPERKLLKALHRPTAGSMNLLRHL-ERSTQLPAVKNTSVNSTSQDAGTSCTMKAQSQSPVCRPSADGIKLPKVGFTFSDFFAARSKKQAVKLTGDLRPGDFIDLGPVPTSQTPLSPILSGA---RLRASQLVKAKGGLEAMEARAKQHREVSIKASLGEQSVDRHRPSPLSQILDNNSSGPSATESNPLSLNTHPSGTENEPPDMSAAAARKKRLAELAKKVREGSSHTGLI---AEAEINSEQARMAVLEKRDEFEQKLTGKTEEQCTYVCCRTCNYRAWKLSDDCRNSSHSVVYLKGLKRYFKCKNCLKRTVTFERYPTVACKNCGESLFEKTGIIRERKGPMLPGEKLLPRGVEEKFLS 917
[Close]
BLAST of Mcm10 domain-containing protein vs. TrEMBL
Match: A0A075ABK5 (Mcm10 domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_14289 PE=4 SV=1)

HSP 1 Score: 234.187 bits (596), Expect = 6.180e-62
Identity = 196/670 (29.25%), Postives = 305/670 (45.52%), Query Frame = 2 
Query:  404 EKQPVKNSSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQV-----LTPHKLCQGNM-----KDSLSDTDWILVGVI-VQAACKKDKNNNNFSIWHLNDLQCLDKA-----VKVMLFRQVYEQFWKEATGTVVAILQPKSLP---TNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKA-ISRPGFVNLGFERLNERKRSAAGMAMPP--------LEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGN---MAAPVKMSAKDVSMVKLLRKPTAGTKNLVKH--------------IVEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKI-AVPNRRTAD--------------SLDNKAKKPALSE------------------------------EMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEK---FETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQ---VASETLKVHGNEKRFIN 2125
            +K  V ++  Y++A PTK+RVY  +V+S+ W +R S RQV        H+  Q  +     K   S    ++VGVI  +   ++ KN+  +SIWHL+DL  +        VK+ LF   +E+ WKE  G+VVAIL P+ +    T+ N K    T  +   ++VLG+SPD+GIC   +KSG+SC +V+NKS C  C  HV+  Y++A  SRPGF +     L +R  +      PP        L  ++   P    +    SR  +++ KL  +G T  ++  GL  +    + AG+         +S+ +  +VK L +PTAG+ NL++H              +  +S  P    S   + +       A    GFTF  F   R +  A +       G  IDLG  PV   Q       +   +LR +   K  GG  AM+   +Q     I A    ++AD              SL + A KP  S                               E+ K + +GSS+  L+     A+ + +  +M V+EK   FE KLT + E++C    C  C  +  +    C    H+V  +KG +RYFKC  C  RT T+++YP  +C  CG   +E+TG ++ER+   +  E L   G E++F++
Sbjct:  257 KKSVVSSAPDYWLAVPTKLRVYRSKVSSELWANRTSDRQVYGLLQFIQHQRSQVTLSMPSSKRQSSTDSLVVVGVIGSKTPPRRSKNDRIYSIWHLSDLDQVGPGSHIGCVKLFLFGDAHEKLWKEPDGSVVAILGPRLMSDPSTSFNDKDVGITPPSPQHVMVLGQSPDYGICAALNKSGQSCFHVINKSVCRYCDLHVKKAYYEASSSRPGFFDSSHPALKKRPTNRYKGDRPPVNEPGVYSLPTSKMFNPVSPSR--SESRVKLTVAKLSAAGYTVDSS-VGLATQQHRVDGAGDPSRPPPSQPLSSPERKLVKALHRPTAGSMNLLRHLERSTQLLEVKNTSVNSRSQDPGTSCSMETQSHSHVCRPSADPKVGFTFSDFFAARSKKQAVKLTNDLRPGDFIDLG--PVSTSQTPMSPILSGA-RLRASQLVKAKGGLKAMEARAKQRSEVSIKASLGEQSADRHRPSPLSQILDNNSLGSSAAKPVSSSNPPSLDAHPNGTENEPPEMSAAAARKNRLAELAKKVREGSSHTGLI---AEAEINSEQARMAVLEKRDEFEQKLTGKTEEQCTYVCCKTCNYRAWKLSDDCRKSNHSVVYLKGLKRYFKCKNCLKRTVTFERYPTVACKNCGESLFEKTGIIRERKGPLLPGEKLLPRGIEEKFLS 917
[Close]
BLAST of Mcm10 domain-containing protein vs. TrEMBL
Match: A0A5K3FN73 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 2.019e-61
Identity = 178/638 (27.90%), Postives = 294/638 (46.08%), Query Frame = 2 
Query:  464 VYNPQVTSDNWKDRISGRQVLTPHKLCQ-------GNMKDSLSDTDWILVGVI-VQAACKKDKNNNNFSIWHLNDLQCLDKA------VKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSS------AFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKA-ISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQ------QSGITARATEWGLLDKTSSGNM----------AGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESF----KQKRMESIAAQNA-----PVASTGQSIDLGYKPVKLD---QVSAEVYRAELN--KLRIAAQAKEMGGYAAMKESNRQEHLRKIAVPNRRTADS----------LD--------------NKAKKPALSE-------EMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQ---VASETLKVHGNEKRFI 2122
            V  PQ++S+ W  R   R+V   H+  +        N++  ++    +LVGVI  +   ++ +NN  +SIW L DL  +         V + LF  V+E+ WKE  GTV+A+L+PK LP+NEN  S       + TVD+A  ++ LG SPDF +C G +K+G  CT +VNK+ C  C +HV++ Y+ A  SRPGF +  F R    +      A  P  ++++        Y+ N  + + + + Q       S    +         TSSG +          + +  +  ++S  +  +   L +P+ G+ NL++H+ E     ++  +N   ++R       + + G TF SF    K+K  E  A         P +     IDLG  P+         A      +N  + RI A  +  GG  A+    R+   ++++    R+A            LD              ++ ++ A SE       E+ +L+SQGSS+  L   +++      L ++E  +  E  L  QHEQEC V  C+ C  ++ R  + C  EGH ++     RR+F C  C TRT+T D+YP  +C  CG   YE+TG + ER+   +  E L + G E++++
Sbjct:   12 VSRPQISSELWMTRTCNRRVFGLHQYVREVKAANGSNLQTEMT----VLVGVIGTKVPPRRSRNNKIYSIWRLTDLASVGTGSTNGPNVSIFLFGAVHEKLWKEPEGTVIAVLKPKLLPSNENDASCNAATDLSITVDSAPFVMPLGVSPDFAVCAGTTKAGRPCTRIVNKNVCRYCDFHVKAAYYSASSSRPGFTSSSFPRTGHGRGRGGRAAPYPSVFSQQT-----AHYSLNRPASMPINRDQDKSFPCDSQTPPQRVALSKAKLTSSGYVMESSSLTLSSSASGVSKSQLSKSENILASRLSRPSRGSLNLLRHL-EALSDDKSKSNNSALRSRSLKTLLPSGSDG-TFASFFADAKKKVQEKAAGPQLCRGIDPASENDNFIDLG--PISTSNPTHTGALTVLPSINGARRRIEALVRSKGGVEALDRLERERTQKRLSEVVSRSASKRPRPSPLSQVLDTAPPPSGNVDPEETHRDEEKAASEKRRHANHELAQLVSQGSSHSDLAAADEVLAEKRLLSRLEARDSIEEHLLGQHEQECQVVTCLTCNYRSLRAGRLCRKEGHRLEITTATRRFFACRNCKTRTSTLDRYPQYACTSCGESLYEKTGAISERRGPKLPGEKLLIRGLEEKYL 636
[Close]
BLAST of Mcm10 domain-containing protein vs. TrEMBL
Match: A0A0V0J6R9 (Protein MCM10 homolog OS=Schistocephalus solidus OX=70667 GN=MCM10 PE=4 SV=1)

HSP 1 Score: 226.483 bits (576), Expect = 8.678e-61
Identity = 182/663 (27.45%), Postives = 314/663 (47.36%), Query Frame = 2 
Query:  473 PQVTSDNWKDRISGRQVLTPHKLCQGNMKDS-----LSDTDWILVGVI-VQAACKKDKNNNNFSIWHLNDLQCLDKA------VKVMLFRQVYEQFWKEATGTVVAILQPKSL-PTN--ENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAIS-RPGFVNLGF------------------ERLNERKRSAAG----MAMP---PLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITAR-----ATEWGLLDKTSSGNMAG-NMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEK----SIGPEAIGSNIVKQNRIFD--DTPATAAKGFTFESFKQKRMES-----IAAQNAPVASTG-QSIDLGYKPVKLD--------------------QVSAEVY----------RAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKI-----------------AVPNRRTADSLDN-KAKKPALSEEMLKLLSQGSSNRKLVEVEKMADFDEK--LDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEKRFIN 2125
            P ++S+ W  R +GR VL+  +  Q   + +     L  +++++VGV+ ++   ++ KN+  +SIW L D+  +         V + LF  V+E+ WKE  GTVVAIL+PK + P++  ++ +  + TVD+A  +++LG SPDFG C G +KS + C+ ++NKS C  C +HV+S Y+ A S RPGF    F                  +  + R+ S +G    ++ P   PL    +         +   R  +SL KL  +G +       A     +   S G +A  N   PV+      ++   + +P+ G++NL++H+ ++    S G + + S   K NR  +   TP   A   TF +F   R  +      +A++ PV   G Q ++ G     +D                    ++ AE +           AE  K+ + ++  E+   +   ++ R   L ++                 +  +R  AD  +  K+++ A   E+ +L+SQGS   +LVE+E  AD  ++  L ++E  ++FE +L +QHEQEC +  C  C  ++ R  + C  +GH ++   G RR+F C  C  RTT+ D+YP  +C  CG   +ER G + ER   ++ SE L   G E+ F++
Sbjct:    3 PLLSSELWATRTAGRNVLSLAQFLQEAARGAPKPLALQASEFVVVGVVGMKTPPRRSKNDKIYSIWRLTDMAGVGTGGAQSSLVSLFLFGSVHEKLWKEPEGTVVAILKPKIMSPSDMEDSDREVSITVDSAPFVMILGTSPDFGTCAGTTKSNKPCSRIINKSVCRYCDFHVKSAYYAASSIRPGFSTTNFPWTGHSNGRGGRGGGRGWKTGHAREISGSGGIFSLSRPATMPLSGTLDDHLHPGVSNSSFVRPKLSLAKLTSAGYSVSNGPNPAISSCAVPPVSGGGIAAQNALTPVEQ-----TLASRISRPSLGSRNLLRHLEKQNPVTSPGSQQVNSRSSK-NRDPEPSPTPQLPAPAGTFANFFAGRSSARDDRRPSAKSPPVLGRGLQGVEAGSPNCLIDLGPVVSSSHTSTAPPARNAARMRAEAFVRARGGVARLEAEARKVAVGSRVSELVASSGSSQTTRPSPLSELLGNAPSNGGPTKSASRDSETSRSDADLQEGEKSRREAKRAELARLVSQGSQYTELVELE--ADLSDRSLLCRLEKRDEFEERLLSQHEQECQIVTCKTCNYRSLRADRECRKQGHILEFSTGTRRFFACRNCKARTTSLDRYPTLACKNCGESLFERAGAIAERKGPKLLSEKLLARGLEETFLS 657
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Cavefish
Match: mcm10 (minichromosome maintenance 10 replication initiation factor [Source:NCBI gene;Acc:103027409])

HSP 1 Score: 136.732 bits (343), Expect = 8.439e-33
Identity = 64/182 (35.16%), Postives = 103/182 (56.59%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF 1000
            +R+  P+++S   + +++ R+++   +L     KD+L D+DW+   V++     + KNN   FSIW LNDL  L+  V + LF  V+   WK  TGTV+ IL P  +   E     + TVD   ++L++G + DFG C+ K K+G+SCT +VN  +C  C YHV++ Y K  S+   +   F
Sbjct:  252 LRLRRPRLSSVEIESKMANRRMIKLSQLPDRLAKDNLEDSDWVTFAVVINKITPQSKNNGKTFSIWKLNDLHNLEVNVSLFLFGTVHTDLWKTDTGTVIGILNPNQMKNKEGSNELSLTVDHPQKVLMMGEAMDFGTCKAKKKNGDSCTQLVNMYECQFCQYHVKAQYKKMSSKRAELQSSF 433

HSP 2 Score: 66.2402 bits (160), Expect = 8.181e-11
Identity = 45/150 (30.00%), Postives = 69/150 (46.00%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKL---VEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  ++L+  SSN  +   VE + M D+    D +   EK E K+    E +C    C  C+    +    CV E H        +R+FKC  C  R     + P  +C  CG   +ER G +KE+   ++  E L   G E+ +F+N+
Sbjct:  718 SEEFQRILNAKSSNSWIMGEVEAQAMQDY---FDPLVQKEKLEEKMRGIREMKCRAVTCKNCKYTHFKPADRCVEEKHDYHWHDATKRFFKC-PCGQRKICLARLPTAACSNCGLFKWERDGMLKEKKGPKIGGELLLTRGEEQPKFLNS 863
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Cavefish
Match: mcm10 (minichromosome maintenance 10 replication initiation factor [Source:NCBI gene;Acc:103027409])

HSP 1 Score: 136.732 bits (343), Expect = 8.669e-33
Identity = 64/182 (35.16%), Postives = 103/182 (56.59%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNN-NFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF 1000
            +R+  P+++S   + +++ R+++   +L     KD+L D+DW+   V++     + KNN   FSIW LNDL  L+  V + LF  V+   WK  TGTV+ IL P  +   E     + TVD   ++L++G + DFG C+ K K+G+SCT +VN  +C  C YHV++ Y K  S+   +   F
Sbjct:  266 LRLRRPRLSSVEIESKMANRRMIKLSQLPDRLAKDNLEDSDWVTFAVVINKITPQSKNNGKTFSIWKLNDLHNLEVNVSLFLFGTVHTDLWKTDTGTVIGILNPNQMKNKEGSNELSLTVDHPQKVLMMGEAMDFGTCKAKKKNGDSCTQLVNMYECQFCQYHVKAQYKKMSSKRAELQSSF 447

HSP 2 Score: 66.6254 bits (161), Expect = 7.311e-11
Identity = 45/150 (30.00%), Postives = 69/150 (46.00%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKL---VEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  ++L+  SSN  +   VE + M D+    D +   EK E K+    E +C    C  C+    +    CV E H        +R+FKC  C  R     + P  +C  CG   +ER G +KE+   ++  E L   G E+ +F+N+
Sbjct:  733 SEEFQRILNAKSSNSWIMGEVEAQAMQDY---FDPLVQKEKLEEKMRGIREMKCRAVTCKNCKYTHFKPADRCVEEKHDYHWHDATKRFFKC-PCGQRKICLARLPTAACSNCGLFKWERDGMLKEKKGPKIGGELLLTRGEEQPKFLNS 878
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Sea Lamprey
Match: mcm10 (minichromosome maintenance 10 replication initiation factor [Source:NCBI gene;Acc:553396])

HSP 1 Score: 134.035 bits (336), Expect = 1.020e-32
Identity = 82/299 (27.42%), Postives = 144/299 (48.16%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKD-KNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF-----ERLNERKRSAAGM----AMPPLEWNREKQPKMEGKYAGNSRS-GISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKS 1321
             R+  P ++S + + R++GR+++   +L     +DSL + DW+ +GVIV     +   +   FS+W L DL+ ++ +V ++LF +V++Q WK   G VV +L P  +   E +   + +VD   +++++G + D G C+   ++G+ CT ++N  +   C +HVQS Y K  SR   +  GF       L  R R A G+          +     P      A ++ S G    ++  SG   R  +  LL    + ++       V ++        LL+ PT G  NL KH+V+ S
Sbjct:  225 FRIRRPLISSVDMERRMAGRRMIRLSQLPDKITRDSLDNIDWVTIGVIVHKHTPQSVSSGKTFSVWRLMDLKNMEVSVSLLLFGEVHKQHWKTDQGFVVGLLNPTLMKPKEGYNELSISVDHPQKVMLMGEAKDLGTCRAAKRNGDPCTQLINLMEGEFCQFHVQSQYRKMSSRRSELQAGFTGREPTMLRGRGRGALGLKERICQQGFHYGGVSSPAYAASVASSTPSKGSKSTQMSLSGFVVRGADAVLLQAKQNLDV-----LRVFLTGHSEDFQGLLKAPTPGALNLKKHLVQIS 518

HSP 2 Score: 73.1738 bits (178), Expect = 1.306e-13
Identity = 37/111 (33.33%), Postives = 59/111 (53.15%), Query Frame = 2 
Query: 1808 EKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            E+ E K+    EQ+C V  C QC+    +    CV + H +    G +R+F+C +C  RT + D+ P   C  CG   +ER   +KER   ++ +ETL   G E+ +F+N+
Sbjct:  740 EQMEEKMKNLKEQKCRVVSCKQCKYTHYKALDTCVQQMHALSWHDGVKRFFRCGQCSHRTVSLDRLPQKHCKNCGQFKWERDSMLKERKGPKIGAETLLPRGEEQAKFLNS 850
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Nematostella
Match: EDO32763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SU52])

HSP 1 Score: 96.2857 bits (238), Expect = 4.279e-23
Identity = 48/158 (30.38%), Postives = 85/158 (53.80%), Query Frame = 2 
Query:  503 RISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIV-QAACKKDKNNNNFSIWHLNDL--QCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNE-NFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFK 964
            R+ GR+++   ++     K    D DW+ +G +  +   +   N N + IW L+DL     +  V + LF +VY+Q WK   G+V+A+L    +P  E N +  A ++D   +++++G S D G C+G ++  + CT++VN+     C YHV + Y K
Sbjct:    4 RMEGRKIVPISQIESKLSKGKEKDIDWVTIGALASKLPPRTSSNGNTYGIWKLSDLGLTTANNTVALFLFGEVYKQHWKTIEGSVIALLNANIMPAKEKNSQDVALSLDNPKKLMLMGISKDLGHCKGITRKEKPCTSIVNREYGDFCEYHVNAAYKK 161
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Nematostella
Match: EDO32764 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SU53])

HSP 1 Score: 64.3142 bits (155), Expect = 7.871e-11
Identity = 40/122 (32.79%), Postives = 58/122 (47.54%), Query Frame = 2 
Query: 1778 DEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYD-KYPDGSCLKCGACAYERTGRMKERQ---VASETLKVHGNE-KRFINN 2128
            ++    +E  E+ E KL +  E    V+ C +C          C  E H +K  K  +R+F C  C  RT +Y  + P  +C  CG   YERT    E+Q   +A ETL V G E  +F+N+
Sbjct:  357 EQYFSSLEKKEQLEDKLKSIKEIIVKVYCCKKCDYVAESASDICFKENHPLKQTKAPKRFFSCKNCKQRTISYGARMPKLTCKNCGEMNYERTSMFMEKQGPKIAGETLLVRGEEHSKFMNS 478
[Close]
BLAST of Mcm10 domain-containing protein vs. Ensembl Medaka
Match: mcm10 (minichromosome maintenance 10 replication initiation factor [Source:NCBI gene;Acc:101161872])

HSP 1 Score: 135.191 bits (339), Expect = 2.540e-32
Identity = 59/182 (32.42%), Postives = 107/182 (58.79%), Query Frame = 2 
Query:  458 IRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIV-QAACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGF 1000
            +R+  P+V+S     +++ R+++   ++ +   ++ L D+DW+  GV+V +A  +  ++   FSIW LNDL  LD  V ++LF +V+++ WK   GT + +L P  +  N+ +K  + TVD   ++LVLG + D+G C+   K+G+ C+ +VN  +C  C YHV++ Y K  S+   +   F
Sbjct:  306 LRLRKPRVSSVEMDQKMASRRLIRLSQVPERLTREKLEDSDWVTFGVLVDKATPQSSRSGKTFSIWKLNDLHGLDVFVSLLLFGEVHKEHWKMEPGTAIGLLNPNPMKQNDGYKGVSLTVDHPQKVLVLGEAQDYGTCKASKKNGDPCSQIVNLYECQYCQYHVKAQYKKMSSKRAELQSSF 487

HSP 2 Score: 63.5438 bits (153), Expect = 5.664e-10
Identity = 40/147 (27.21%), Postives = 68/147 (46.26%), Query Frame = 2 
Query: 1700 SEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKER---QVASETLKVHGNEK-RFINN 2128
            SEE  K+L+  S +  +++  +    +   D +   E+ E K+    E +C    C +C     +    CV E H ++     +R+F+C  C  R    D+ P   C  CG   +ER G +KE+   ++ +E L   G E  +FIN+
Sbjct:  769 SEEFQKILNAKSRHETVLQAAEYQLQERYFDALVKKEQMEEKMKGIKEMKCRAVTCKKCSYTYFKPADRCVQESHDLRWHDAVKRFFRC-PCGQRAIALDRLPHKHCSNCGLFKWERDGMLKEKTGPKLGAELLLPRGEEHAKFINS 914
[Close]
BLAST of Mcm10 domain-containing protein vs. Planmine SMEST
Match: SMESG000014794.1 (SMESG000014794.1)

HSP 1 Score: 1348.18 bits (3488), Expect = 0.000e+0
Identity = 656/660 (99.39%), Postives = 660/660 (100.00%), Query Frame = 2 
Query:  149 MNKDEYVMKIGKDRALTAAEVNDFLGFSDSNSDGSDWETIKDDAADNFLXXXXXXXXXXXXFEINNQTKMVMPGDIIHKNDLPAPEKQPVKNSSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVQAACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPALSEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVASETLKVHGNEKRFINN 2128
            MNKDEYVMKIGKDRALTAAEVNDFLGFSDSNSDGSDWETIKDDAADNFLKKKEEVKPVKRKFEINNQTKMVMPGDIIHKNDLPAPEKQPVKNSSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIV+AACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGN+RSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESFKQKRMES+AAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKIAVPNRRTADSL+NKAKKPALSEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVASETLKVHGNEKRFINN
Sbjct:    1 MNKDEYVMKIGKDRALTAAEVNDFLGFSDSNSDGSDWETIKDDAADNFLKKKEEVKPVKRKFEINNQTKMVMPGDIIHKNDLPAPEKQPVKNSSKYFIAEPTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGVIVRAACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTVVAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESCTNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMPPLEWNREKQPKMEGKYAGNTRSGISLEKLQQSGITARATEWGLLDKTSSGNMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSNIVKQNRIFDDTPATAAKGFTFESFKQKRMESLAAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLENKAKKPALSEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKMEVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGFRRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVASETLKVHGNEKRFINN 660
[Close]
BLAST of Mcm10 domain-containing protein vs. Planmine SMEST
Match: SMESG000054891.1 (SMESG000054891.1)

HSP 1 Score: 144.821 bits (364), Expect = 7.342e-41
Identity = 72/95 (75.79%), Postives = 82/95 (86.32%), Query Frame = 2 
Query: 1433 MESIAAQNAPVASTGQSIDLGYKPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKIAVPNRRTADSLDNKAKKPALSEEMLK 1717
            M+SIA+QNAP AST Q+IDLGYKP+KLDQV+A+VYR EL+KLRI  QAK+MG Y A+KESNRQEHLRKIAVPNR T +SL NKAK  ALSE MLK
Sbjct:    1 MKSIASQNAPAASTAQTIDLGYKPMKLDQVNADVYRIELDKLRILVQAKKMGEYTALKESNRQEHLRKIAVPNRSTVNSLVNKAKS-ALSEVMLK 94
The following BLAST results are available for this feature:
BLAST of Mcm10 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
MCM105.939e-3033.53minichromosome maintenance 10 replication initiati... [more]
MCM106.107e-3033.53minichromosome maintenance 10 replication initiati... [more]
MCM107.901e-3033.53minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mcm-105.202e-1627.98Yeast MCM (Licensing factor) related [Source:UniP... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Mcm104.521e-2430.29gene:FBgn0032929 transcript:FBtr0081475[more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mcm104.980e-3335.16minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
phax1.759e-4926.43phosphorylated adaptor for RNA export [Source:Xenb... [more]
phax1.603e-4825.71phosphorylated adaptor for RNA export [Source:Xenb... [more]
phax5.572e-3525.23phosphorylated adaptor for RNA export [Source:Xenb... [more]
phax2.975e-3427.93phosphorylated adaptor for RNA export [Source:Xenb... [more]
phax2.377e-3128.57phosphorylated adaptor for RNA export [Source:Xenb... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Mcm101.661e-2932.35minichromosome maintenance 10 replication initiati... [more]
Mcm101.661e-2932.35minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q28E45|MCM10_XENTR9.319e-4926.43Protein MCM10 homolog OS=Xenopus tropicalis OX=836... [more]
sp|Q5RHY1|MCM10_DANRE3.759e-3235.16Protein MCM10 homolog OS=Danio rerio OX=7955 GN=mc... [more]
sp|Q5EAW4|MCM10_XENLA8.655e-3228.79Protein MCM10 homolog OS=Xenopus laevis OX=8355 GN... [more]
sp|Q7L590|MCM10_HUMAN2.933e-2933.53Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=M... [more]
sp|Q0VBD2|MCM10_MOUSE1.162e-2832.35Protein MCM10 homolog OS=Mus musculus OX=10090 GN=... [more]
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BLAST of Mcm10 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A564YG191.986e-6727.76Mcm10 domain-containing protein OS=Hymenolepis dim... [more]
A0A4S2LJT02.049e-6328.38Mcm10 domain-containing protein OS=Opisthorchis fe... [more]
A0A075ABK56.180e-6229.25Mcm10 domain-containing protein OS=Opisthorchis vi... [more]
A0A5K3FN732.019e-6127.90Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0V0J6R98.678e-6127.45Protein MCM10 homolog OS=Schistocephalus solidus O... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mcm108.439e-3335.16minichromosome maintenance 10 replication initiati... [more]
mcm108.669e-3335.16minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mcm101.020e-3227.42minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mcm10 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO327634.279e-2330.38Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO327647.871e-1132.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mcm10 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mcm102.540e-3232.42minichromosome maintenance 10 replication initiati... [more]
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BLAST of Mcm10 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000014794.10.000e+099.39SMESG000014794.1[more]
SMESG000054891.17.342e-4175.79SMESG000054891.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30001057 ID=SMED30001057|Name=Mcm10 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2174bp
TTTGGATATTTTAAAAAAGATATTTTTTATTTTTTTGACAATAAGTCATA
TTGTTTAAAATTCATAATATTTTATCAAATTAAAGGTGTAATAATTTTCA
GAGAATAATTAGTTTAAATATATCACTTTAAAGATTATTATATAGAATAT
GAACAAAGATGAATATGTAATGAAAATAGGTAAAGATCGAGCCCTGACTG
CTGCCGAAGTCAACGATTTCCTTGGTTTCAGTGATTCAAATTCCGATGGA
AGTGATTGGGAAACTATAAAGGACGATGCAGCCGATAATTTTTTAAAGAA
AAAAGAAGAAGTTAAACCTGTTAAAAGAAAATTTGAAATAAATAACCAAA
CAAAAATGGTAATGCCTGGAGATATTATACACAAAAACGATCTGCCTGCT
CCAGAAAAGCAACCAGTAAAAAATAGTTCCAAGTATTTTATTGCCGAACC
AACTAAAATTCGAGTCTACAATCCACAAGTGACAAGCGACAACTGGAAAG
ACCGGATTTCAGGCAGACAAGTGTTGACGCCCCACAAATTGTGCCAGGGG
AACATGAAGGACAGTCTGAGCGACACCGACTGGATTCTAGTGGGAGTTAT
CGTCCAAGCAGCTTGCAAGAAGGATAAAAACAATAACAATTTCTCAATTT
GGCATTTGAATGATTTGCAGTGCCTGGACAAAGCCGTGAAGGTGATGCTA
TTCCGGCAGGTCTATGAGCAGTTCTGGAAGGAAGCCACCGGCACCGTTGT
AGCGATCCTGCAGCCGAAATCTCTACCGACCAATGAGAATTTCAAATCGA
GCGCCTTCACCGTGGATACCGCGCTCCAGATTCTGGTGCTCGGCCGCTCT
CCCGATTTCGGCATTTGCCAGGGAAAATCAAAATCCGGTGAATCGTGCAC
AAATGTCGTCAATAAATCCGACTGTTCCATGTGTTCCTATCATGTCCAAT
CCGGATATTTCAAGGCGATCTCTCGTCCGGGATTCGTCAATCTCGGATTC
GAGCGGCTGAATGAGAGGAAGCGATCGGCTGCTGGCATGGCAATGCCGCC
GTTGGAGTGGAACAGAGAGAAGCAGCCGAAAATGGAGGGGAAATATGCCG
GTAATAGCCGATCAGGGATATCCCTGGAGAAACTGCAGCAGTCCGGCATC
ACTGCTAGGGCTACCGAGTGGGGATTGCTGGACAAGACAAGTTCGGGTAA
CATGGCGGGTAACATGGCGGCCCCGGTCAAAATGTCAGCAAAGGATGTCT
CGATGGTGAAATTGCTGAGGAAGCCGACTGCTGGAACGAAGAATCTCGTG
AAACACATTGTGGAGAAATCCATCGGCCCGGAAGCCATCGGCAGCAATAT
AGTGAAGCAGAACCGGATATTCGATGACACACCAGCAACCGCTGCCAAGG
GATTCACGTTCGAGAGCTTCAAACAGAAACGGATGGAAAGCATTGCCGCA
CAGAATGCGCCCGTCGCCTCCACTGGCCAATCGATCGATCTCGGATATAA
ACCGGTGAAACTCGATCAGGTCAGTGCTGAAGTGTATCGCGCGGAATTGA
ATAAGCTGCGAATTGCAGCCCAAGCCAAAGAAATGGGAGGATATGCCGCA
ATGAAAGAAAGCAACCGACAGGAACATTTGAGGAAAATCGCAGTTCCTAA
CAGAAGGACCGCCGATTCACTGGACAATAAAGCCAAGAAACCTGCATTAA
GCGAAGAAATGCTGAAGCTATTGAGCCAAGGCTCCTCGAATCGGAAATTG
GTGGAAGTGGAAAAGATGGCGGATTTCGATGAGAAGCTGGATAAAATGGA
GGTGATTGAGAAATTCGAAACGAAATTGACCACTCAACATGAGCAAGAGT
GCGTGGTGTTCATTTGTGTGCAATGCCAGACAAAGACCGGGAGGCAGCCG
AAGGGCTGTGTGACAGAAGGGCACACAGTCAAGTCCATCAAGGGATTCAG
GAGATATTTCAAGTGCATTAAATGCCATACAAGGACGACAACCTATGATA
AATATCCGGATGGCTCTTGTTTGAAATGCGGAGCTTGTGCCTATGAGAGG
ACAGGAAGGATGAAGGAACGGCAAGTCGCATCAGAAACTCTGAAAGTTCA
CGGAAATGAGAAGAGATTTATCAATAACTAATTTTATGCATTTTTATCAT
AATATTTTAATTCAATAAATTTAC
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protein sequence of SMED30001057-orf-1

>SMED30001057-orf-1 ID=SMED30001057-orf-1|Name=SMED30001057-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=661bp
MNKDEYVMKIGKDRALTAAEVNDFLGFSDSNSDGSDWETIKDDAADNFLK
KKEEVKPVKRKFEINNQTKMVMPGDIIHKNDLPAPEKQPVKNSSKYFIAE
PTKIRVYNPQVTSDNWKDRISGRQVLTPHKLCQGNMKDSLSDTDWILVGV
IVQAACKKDKNNNNFSIWHLNDLQCLDKAVKVMLFRQVYEQFWKEATGTV
VAILQPKSLPTNENFKSSAFTVDTALQILVLGRSPDFGICQGKSKSGESC
TNVVNKSDCSMCSYHVQSGYFKAISRPGFVNLGFERLNERKRSAAGMAMP
PLEWNREKQPKMEGKYAGNSRSGISLEKLQQSGITARATEWGLLDKTSSG
NMAGNMAAPVKMSAKDVSMVKLLRKPTAGTKNLVKHIVEKSIGPEAIGSN
IVKQNRIFDDTPATAAKGFTFESFKQKRMESIAAQNAPVASTGQSIDLGY
KPVKLDQVSAEVYRAELNKLRIAAQAKEMGGYAAMKESNRQEHLRKIAVP
NRRTADSLDNKAKKPALSEEMLKLLSQGSSNRKLVEVEKMADFDEKLDKM
EVIEKFETKLTTQHEQECVVFICVQCQTKTGRQPKGCVTEGHTVKSIKGF
RRYFKCIKCHTRTTTYDKYPDGSCLKCGACAYERTGRMKERQVASETLKV
HGNEKRFINN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003690double-stranded DNA binding
GO:0003697single-stranded DNA binding
Vocabulary: biological process
TermDefinition
GO:0006270DNA replication initiation
GO:0006260DNA replication
GO:0006516glycoprotein catabolic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000240body wall musculature
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR040184Mcm10
IPR015411Rep_factor_Mcm10_C
IPR015408Znf_Mcm10/DnaG
IPR006588Peptide_N_glycanase_PAW_dom
IPR011051RmlC_Cupin_sf
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR015411Replication factor Mcm10, C-terminalSMARTSM01280Mcm10_2coord: 356..660
e-value: 2.8E-14
score: 63.4
IPR015411Replication factor Mcm10, C-terminalPFAMPF09332Mcm10coord: 462..659
e-value: 2.9E-32
score: 112.5
NoneNo IPR availableGENE3DG3DSA:2.40.50.140coord: 89..267
e-value: 1.3E-47
score: 163.5
IPR015408Zinc finger, Mcm10/DnaG-typePFAMPF09329zf-primasecoord: 232..272
e-value: 4.4E-13
score: 48.8
IPR040184Minichromosome maintenance protein 10PANTHERPTHR13454FAMILY NOT NAMEDcoord: 83..642