FMRFamide-activated amiloride-sensitive sodium channel
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30000964 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1) HSP 1 Score: 70.0922 bits (170), Expect = 3.956e-11 Identity = 120/556 (21.58%), Postives = 222/556 (39.93%), Query Frame = 3 Query: 132 DIFSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSH-LKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTM----SGTFHDISSLIVVASLIPSSLIPELKDAFVMD--ILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRE-TVNEINET---------------IICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLEN-KYQNYRNSLDNDSLNEDRFT-------------YIKLIRKNK-NTTIKIEKLIL---------DVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQM 1658 DI + + S+ G+ KI ++ KV+W V + + LLV++YL + + K +P++++C+ P SL+ +++ N+ + +L I + F+ + ++ FY L + LSH L++ C + + L + F NYFNC+T + + +G + +S + V P +P + D IL G+++V+H G+ P G +I PG + + + I L P C +D +++ + + YTF C+ Q+L+++ C C SS P + N F W+E N NE + C N+ + CF C+ +Y ++S++ W +L + R ++ +N KT + +LE + + ++ NDS +D + LIR+N I +E L + +A L + IGG L++G++V +ELIE + L + Sbjct: 41 DIIAELGSESNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRT-----IRRMYFNNESQNLITWLRFIQKFR-----FEQDSFMNSIRAFYENLG-QDAKKLSHNLEDMLMHCRFNRE------------LCHVSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDP---LPGTYGVYNFDNNILHSA-GVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTND---MLNGIKQYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYE----YLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVIRLTGL 562
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A183THX6 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS16074 PE=3 SV=1) HSP 1 Score: 378.637 bits (971), Expect = 8.512e-120 Identity = 208/548 (37.96%), Postives = 324/548 (59.12%), Query Frame = 3 Query: 117 MTDSNDIFSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHL-YDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPR---HKTPNEKFPYCFNVWRETVN-----EINETIICTSNFMNNMKA-RKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDNDSL------------NEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNSTEKTD 1694 M + + F +FC +SIRG+Q+I KA T F +V+W FV T L +TI L +++L Y TAWH T + D++ FPAIT+C+HNPFSL+AN +W+ +I +P F KRL + L + +DK+ + +++L D +N+Y L NE+ LSH + F C+V ++++ NC + + R FSH YFNCWT+E S + L ++ L+PS I E K+ F+MD RGEG+K+V+HE+GTYP+IDKDG N+QPG++NE++++ IKW L TP+ C +D K I D+ + Y TQC+D+ LQ + + C CL+S WPR N K PYC + ++ N ++ E + C + ++ +K ++ +++ C C+++TY + SIT W P +KL+ Q VE L N K+ F +LE + +++ ++ NE +TYI L+R + +TT++ E+LI D IL+SR+GGLCS+F+GLT AF +ELIEFIYL+ + + Q ++ +K D Sbjct: 1 MPELRNNFDLFCELTSIRGLQRIKKAPTFFGRVIWSAFVIAMTLSLFITIGFLARDFLSYNTAWHARTIIGDKANFPAITVCAHNPFSLEANTIWKKNEILTPTGFNKRLSEITLEFIKHDKLE--YASVMLLDSTENYYANLRPNESQTLSHQTDMFPHCMVTADGVRILAENCAVEADTGFTKRYFSHPRYFNCWTLETAANHST--RETVRLTLLIRLVPSVEIDEAKNNFIMDTFSRGEGVKLVVHESGTYPEIDKDGINVQPGRMNELSFQTIKWVRLQTPIAPCLEDPKPIFDMGSTYTYRLTQCLDSILQNISINSCGCLNSEWPRTVDSALVNTKIPYCSALPKDPKNPDSLKDMVERLTCAGDLLHRVKELKEEAIRQRNCISACSYYTYPVSASITSWKPMPEKLNYFTEKCQRVESLQNNPQQ---KEKFIRYLERTLNSSSADINSSTITSLSSKFAKNFENEGLYTYISLVRTSYDTTLQEERLIFDFYILISRVGGLCSIFVGLTAAFLVELIEFIYLVCRQYKKQDSNVKKKD 541
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A0R3UEW8 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS5596 PE=3 SV=1) HSP 1 Score: 366.311 bits (939), Expect = 4.248e-115 Identity = 210/548 (38.32%), Postives = 316/548 (57.66%), Query Frame = 3 Query: 138 FSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTP---NEKFPYCFNVWR-----ETVNEINETIICTSNFMNNMKARKLSVQMNK-CFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNY---------RNSLD-NDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNS-TEKTDRSGKSLGAD 1721 F+IFC +SIRG Q+I +AQTPF++++W FV T L+VTI L +++ + T+WH+ T ++D++ FPAIT+C+HNPFSL+AN +W I +P +F ++L + L + + + + ++L+D ++ L E+ L H F C+V +V+ NC + + + FSH YFNCWT+E S D L V+ SLIPS I E + F+MD RGEG+K+V+H++GTYP+IDK G N+QPG++NE+++ W L TP C DD I D+ R ++Y TQC+D+ LQ + + +C CL+S WPR P N K PYC + + T+ I + CTSN ++N+K K S +N C PRC+FFTY + SIT W P +KL + VE L+ N D ++ +L+ ++SL D N+ +TYI L+R +TT K E+LI D+ IL+SR+GGLCS+FIGLT A +ELIEF+Y+ + S + + + KTD +G + Sbjct: 8 FAIFCDLTSIRGFQRIKRAQTPFIRMIWTLFVILMTGALIVTIGFLARDFFSFTTSWHSRTLIDDKTDFPAITICAHNPFSLEANRIWAEASILTPTEFNRQLSAMTLAFIENG-NPEYAGLLLQDSTDTYFANLRPEESQRLGHQTTMFPHCMVTADGVNIVAENCMIEGDTGFTKKRFSHPKYFNCWTIETAANQST--KDTVRLTVLLSLIPSKEINESRKNFIMDTFSRGEGVKLVVHQSGTYPEIDKHGINVQPGRMNELSFNTEWWVRLKTPTAPCLDDPPPITDMGRQYSYRMTQCLDSYLQNISINQCGCLNSEWPRPIHPDLVNSKIPYCSALPKNVSDSATLEGIIRRLNCTSNLLHNLKKIKESAILNHICTPRCSFFTYPISASITSWQPIPEKLQHFTDKFKRVERLLNNYDDPLERERLIQYLKEVIDPQEKLSTQIISKSSLRIEDFQNQGSYTYISLVRTTYDTTYKEERLIFDIYILISRVGGLCSIFIGLTAAIIVELIEFVYVGFWLARSDSLAVSTKTDTPELPVGGE 552
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4E0RFC3 (FMRFamide-activated amiloride-sensitive sodium channel OS=Fasciola hepatica OX=6192 GN=D915_003846 PE=3 SV=1) HSP 1 Score: 362.073 bits (928), Expect = 7.608e-113 Identity = 213/523 (40.73%), Postives = 308/523 (58.89%), Query Frame = 3 Query: 144 IFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHL-YDKI--SMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEK---FPYCFNVWRETVNEINETII-----CTSNFMNNMKA-RKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDND---------SLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLL 1649 +F SSIRG+Q+I +A+TPF++ LW+ FV + T +L V+ +L+ +YL Y T+WHT + +D+S FPAIT+C+HNPFSLKAN LW + + SPNQ + ++L L DK+ S++ M L D + +YT L+ ++ +SH E C++ +V+ C + + R FSH YFNC T+E S + DIS L+++A L+PSS I + + AF+MD RGEG+K+V+HE TYP I++ GFN+QP ++NEI YE + WK LSTPV C+D Q I DL + Y +QC+D A Q+ ++ C C++S WPR PYC ++ R + E+ T++ C+ F + R+ ++ C PRC FFTY T LS+T W PS KL + VE + + K SSFL++ +S D + +TYI LIR++ +TT+K EKL+ D ILLSRIGGLCSL IGLT+AFFIE+IEFIY + Sbjct: 75 LFGEISSIRGVQRIFRAETPFIRTLWILFVISMTCLLTVSSFMLIVDYLQYTTSWHTRSLPDDKSEFPAITLCAHNPFSLKANKLWSTGHVISPNQVKSNMAAVSLEMLNQDKVEDSVI---MALSDSFEFYYTNLSPEDSQKISHDFEIIPHCILYSPEHTVVAEKCEMENVTAMVRRTFSHPKYFNCLTIEGGGNESTS--DISRLVLLAHLVPSSKIVQARSAFIMDTFTRGEGIKVVIHERNTYPQIERYGFNVQPNRMNEIIYETLSWKRLSTPVAPCKDSQPPISDLGVNYTYETSQCLDIATQEEMIRRCGCMNSEWPRPTRAVHGPRLVPYCTSMDRNSSVEVTATVLSERLACSRIFFEELPVIRERIIRAGICIPRCRFFTYDTKLSVTSWEPSPVKLSSYTANYRIVEEYLTEPIESK-KKELSSFLQSIIDPTLDSADEQWNKRIGDYKQFGDGTYTYISLIRRDFDTTLKEEKLVFDAPILLSRIGGLCSLCIGLTMAFFIEIIEFIYAV 591
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A183MQX4 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS18449 PE=3 SV=1) HSP 1 Score: 362.459 bits (929), Expect = 6.905e-112 Identity = 215/566 (37.99%), Postives = 326/566 (57.60%), Query Frame = 3 Query: 138 FSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPR-------HKTPNEKFPYCFNVWRETVNEINET------IICTSNFMNNMKA-RKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKD----NFSSFLE-----NKYQNYRNSLDND--SLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLV---QMKESQTNSTEKTDRSGKSLGADKQKLNVHNSK 1751 +FC SSIRG+Q+I +Q PF+++LW+ FV T +L+V+ L+ +YL Y TAW+T + L+D+S FPAIT+C+HNPFSL N+LW+ + SP RL L L L + I+ + D ++ +YT L +N+TI + H K+ C++ + +V+ C + + +R F+H YFNCWT++ K S + D++ LI++A LIP I +F+MD RGEG+K+V+HE GTYP+I+K G NIQPG++NEI YE I WK L TPV C ++ I DL + Y +QC++ LQ L C CL+S WPR HK+ PYC + VN IN + C +N++K ++ +VQ C PRC ++TY T LS+T W P KL + + V+ + + D NF + ++ N+ + R ND ++ TYI LIR++ +T +K E+L+ D+ IL+SRIGGLCSL IGLT+AF +EL+EF+YLL MK +Q+N K + + K++ + ++ +HN + Sbjct: 61 LELFCVLSSIRGVQRIYSSQIPFIRILWILFVIIMTCVLMVSSGFLISDYLCYSTAWNTRSLLDDKSEFPAITLCAHNPFSLNVNSLWKENIVPSPRHIKSRLRQLLLTMLDNGITDYTGDLAFSDSIEFYYTNLNLNDTIKVGHDKDMLYHCMLYEEGSTVVAEKCDLEPETSIRIRRFTHPKYFNCWTIDGKPNASTS--DVTRLIILAHLIPLKKIEGANTSFIMDSFTRGEGIKVVIHEKGTYPEIEKHGVNIQPGRMNEINYETIFWKRLHTPVAPCTNENISIEDLGIYYTYKQSQCLNRMLQNELFTRCGCLNSEWPRSIKLLDQHKS----LPYCQKL-PINVNNINGAEEMKTRLDCFGTVLNDLKQLKEKAVQKGVCIPRCGYYTYDTKLSVTSWDPDPYKLALYTKGYRHVDKFLNEPNQRKHIDELLENFDASIDPIKNKNQLHSIRTLFSNDLQRFDDGTHTYISLIRQDFDTIMKEERLVFDIYILISRIGGLCSLCIGLTMAFLVELVEFVYLLCFKNNMKLTQSNENYKLNHNLKTMKINCKQHCLHNKE 619
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A0R3W907 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS6893 PE=3 SV=1) HSP 1 Score: 357.451 bits (916), Expect = 8.154e-112 Identity = 202/525 (38.48%), Postives = 319/525 (60.76%), Query Frame = 3 Query: 138 FSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTP---NEKFPYCFNVWRE-----TVNEINETIICTSNFMNNMKARKLS-VQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLEN--------KYQNYRNSLDN----DSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLL 1649 F+IFC +SIRG+Q+I +AQTPF++++W FV T L++TI L +++ + T+WH+ T ++D++ FPAIT+C+HNPF+L+AN++W I +P++F ++L + L + + ++ + +++L+D ++ L E+ L H F C+V V +V+ NCT + + + FSH YFNCWT+E S D L ++ SL+ S I E + FVMD RGEG+K+V+H++GTYP+IDK G N+QPG++NE+++ +W L TP C DD I D+ + ++Y TQC+D+ LQ + + +C CL+S WPR P N PYC + ++ T+ I + + CT+N ++N+K K S ++ C PRC+F+TY ++SI W P +KL + VE L+ N D ++ +L+N QN +S+ N D N++ +TYI L+R + TT K E+LI D+ IL+SR+GGLCS+FIGLT A F+ELIEFIY++ Sbjct: 7 FAIFCDLTSIRGVQRIKRAQTPFIRIIWSLFVVLMTGALIITIGFLARDFFSFSTSWHSRTLIDDKTDFPAITICAHNPFALEANHIWAKASILTPSEFNRQLSAITLAFIENG-NLEYASLLLQDSTDTYFANLRPEESRRLGHQTTMFPHCMVTVDGVNIVAENCTIEGDTGFTKQRFSHPKYFNCWTIETADNKST--KDTVRLTLLLSLVSSKEINESRKNFVMDTFSRGEGVKLVVHQSGTYPEIDKHGINVQPGRMNELSFNTERWVRLQTPTAPCLDDPPPITDMGKQYSYRMTQCLDSFLQNISINQCGCLNSEWPRPIHPDLVNTNVPYCSALPKDARDPTTLESIVKRLNCTTNLLHNLKHIKESAIRERICIPRCSFYTYPLSVSIASWEPIPEKLHHFTDKFKRVERLLNNHDDAVERERLVKYLKNVIGLEADDTTQN--SSMSNLRIEDFENQESYTYISLVRTSYETTYKEERLIFDIYILISRVGGLCSIFIGLTAAIFVELIEFIYVV 526
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000029017.1 (SMESG000029017.1) HSP 1 Score: 927.161 bits (2395), Expect = 0.000e+0 Identity = 461/463 (99.57%), Postives = 462/463 (99.78%), Query Frame = 3 Query: 564 LSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDNDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNSTEKTDRSGKSLGADKQKLNVHNSKNSILTKGYPSENVEIYIDNSVFNFDSDTKIEETSDNEVLIWHHGDPNNKLHDGKEGNSYPQTFVSEL 1952 +SHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKLLLEECNCLSSLWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDNDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNSTEKTDRSGKSL ADKQKLNVHNSKNSILTKGYPSENVEIYIDNSVFNFDSDTKIEETSDNEVLIWHHGDPNNKLHDGKEGNSYPQTFVSEL Sbjct: 1 MSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKLLLEECNCLSSLWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDNDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNSTEKTDRSGKSLAADKQKLNVHNSKNSILTKGYPSENVEIYIDNSVFNFDSDTKIEETSDNEVLIWHHGDPNNKLHDGKEGNSYPQTFVSEL 463
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000064696.1 (SMESG000064696.1) HSP 1 Score: 439.499 bits (1129), Expect = 1.538e-146 Identity = 238/541 (43.99%), Postives = 359/541 (66.36%), Query Frame = 3 Query: 75 KRSSRITQFNSKPIMTDSNDIFSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDT-----MVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLENKYQN-YRNSLDNDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNS 1679 K++SR ++ N ++ + F++FC SSIRGM KI KA T FLKVLW+ FVF T +L + LL+K+YL YYTAWH TK +D S FPAIT+CSHNPFSL+AN+LW+ +P F +RL + + D+++ D M+ D+++N+Y + + ++ +SH E ++C + +++ NC + + + +FSH+ +FNC+T++ +T + + I+SLI++ SL P++ IPELK++F+MDILERGEGLK+V+HE +YP+I+++G ++QPGK+N I YEP+KW STP + C++ Q I DL R FNY+F+ C++ LQ L+E C C+++L+PR PNEK YC N+ ++I + C +F N+K K + KC +CN+FTY+T LSITKW+PS +KL RI + + E+ ++N ++ K+++ S+++ N Y NS D NE++FTYI L RK +NT IK E+L+LD+AIL+SRIGGLCSLFIGLTV+FFIEL+EF YL+ + Q S Sbjct: 10 KQASRKSESN---VLVIDKNAFNLFCEISSIRGMHKITKAPTLFLKVLWIAFVFCMTSLLFLVTGLLIKDYLNYYTAWHVRTKFDDNSEFPAITLCSHNPFSLRANSLWKKPNAPNPEMFRERLKQV----VIDEVNTTKDPNELTLMMFHDKIENYYMNIDYDFSLKISHGTEMLKYCAIFSDGLIIITYNCETEKDKVVEKIVFSHQKFFNCYTIQ--QTSNYSQQTITSLIILVSLTPAADIPELKNSFLMDILERGEGLKLVIHEPNSYPEIEEEGIDVQPGKMNNIKYEPVKWARHSTPPQKCKNGQSPIFDLKRQFNYSFSFCMNYNLQLKLIETCGCMNALFPRPFIPNEKIGYCMNLTHRNSSQIFTNLKCAQDFTMNVKTLKKQWENTKCMQKCNYFTYNTELSITKWVPSYEKLFRIADLINKTEIYLKNHRERESKEDYISYIQANITNSYINSSFLDLENENKFTYISLSRKTRNTVIKDEELVLDLAILMSRIGGLCSLFIGLTVSFFIELVEFGYLICRKYSFQKGS 541
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000016707.1 (SMESG000016707.1) HSP 1 Score: 384.415 bits (986), Expect = 6.508e-125 Identity = 217/536 (40.49%), Postives = 330/536 (61.57%), Query Frame = 3 Query: 102 NSKPIMTDSNDIFSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRL--IYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRMFSHRNYFNCWTVEPKKTMSGTF-------HDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEM------LVRNRTD--KTFKDNFSSFLENKYQNYRNSLDN----DSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYL 1646 N P + F+IFC SS+RGMQKI+K++TPFLK LW+ FVF + +L++ LV ++ Y+TAWH ST+L++++ FPAI++CSHNPFS +A+ W+ KI P +F +RL + + LI S L D+ + +Y + +I L H+++ Q+CVV +++ +C + +V FSH NYFNC+T+E K +G ++ SLI++ ++ S + + ++FVMD L RGEGL+IV+H G+YPDIDK+G NIQPGK+NE+ ++ I W S+P + C+DDQ I+DLDR+++YTF QC+DA + K L+E+C C+S++WPR + P++ PYC + + T +K K + KC+P C F TY +TLSIT+W PS+ KL +I + + V L +N T+ + K N+ + L+ + + Y+ +L + + NE + YI L+RKN +TT KIEKL +D+ I +SR+GGLCSL IGLT AFFIE+IEF+YL Sbjct: 41 NHDPNLKTPISKFAIFCEASSVRGMQKIHKSKTPFLKALWIAFVFFMSILLIIISTNLVIDFRNYHTAWHVSTELDEKTRFPAISICSHNPFSKQASRYWKEGKILPPEKFRERLFEVEMELIK-----SGNLPGQTLLDKAEEYYGNVDYPSSIKLGHVRKILQYCVVQNDGFTIIAEDCLVENETGFTVSQFSHYNYFNCFTIEAKSEKNGLIKSYGDKTNETVSLILLINVNLFSDLFQANESFVMDSLTRGEGLRIVIHRVGSYPDIDKNGINIQPGKMNEVNFQNIHWTRYSSPKRECKDDQPPIVDLDRIYDYTFAQCLDAIVNKELVEKCQCMSTIWPRPQLPSKDVPYCNDYSGNLTTIVKRTQCVYEEVFQKLKPIKAAAVGTKCWPLCTFNTYDSTLSITRWKPSLLKLRQITKRYRSVNKYIDDISLAKNNTETIEQLKSNYINELKRELK-YKPTLSHHKSEEIFNEHQMNYINLVRKNFDTTKKIEKLFIDIYIFISRVGGLCSLCIGLTTAFFIEIIEFVYL 570
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000081715.1 (SMESG000081715.1) HSP 1 Score: 355.91 bits (912), Expect = 2.900e-114 Identity = 222/605 (36.69%), Postives = 338/605 (55.87%), Query Frame = 3 Query: 144 IFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTMVLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDL-SEYLSVRMFSHRNYFNCWTVEPKKTMSGTFHDISSLIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRET-VNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRVQQEVEMLVRNRTDKTFKDNFSSFLE--NKYQNYRNSLDNDSLN---------EDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYLLVQMKESQTNSTEKTDRSGKSLGADKQKLNVHNSKNSILTKGYPSENVEIYIDNSVFNFDSDTKIE----ETSDNEVLIWHHGDPNNKLHD 1907 +FC SSIRG+ KI+ A+T F + LW GFV T +L V +V L+++YL Y TAWHTST+L+ S FPAIT+C+ NPFS+ AN LW +KI SP++ L ++L DK + + L D FY L +TI L H K+ ++C++ ++ +++ C DL +E ++++FSH+ YFNC+T+E + + D+ LI++ +IPS IPEL ++F++DIL+RGEGLK+ +H+ TYPDI+ G N+ P K+N + Y P KW +ST CRD QK I DL+R F Y FTQCV A +Q+ ++++C C+ S PR PNE PYC + T I E + C N + + ++Q + CF +C F TY TT+S+T+W + KL + + + N + + S L N+ N R+ ++ + N E+ FTYI L+R+N + K EKL+LD L SR+GGL S+ IGLT A F E IEF+Y + ++ T KTD + + V+ ++ G+P ++ ++F+FD + K E S +E D N +L+D Sbjct: 6 LFCQISSIRGISKIHSAKTKFERFLWTGFVILMTCVLFVQMVFLIQDYLQYTTAWHTSTELDYPSPFPAITLCAQNPFSIDANRLWSKRKIMSPSELQDNLTIMSLNAFDDKNLDGLEYLRLYDLFSTFYMNLPFLDTIKLGHSKDMIRYCILIYKNDIIIAEKC--DLKNEKFNIKLFSHQEYFNCYTIEGLEQYTT---DVIGLILLVQIIPSEKIPELSNSFLVDILQRGEGLKVAVHQPQTYPDIENSGINMHPAKMNSLVYSPTKWIRMSTSKNPCRDKQKPINDLNRHFKYAFTQCVSAEIQRQIIKQCGCMLSNAPRPYPPNETIPYCIKLVSPTKAKLILERLSCVENIQSQSVEIRKTIQNDLCFLKCQFTTYETTMSLTRWTANELKLKNLENLYRSYFAYRHNSSSENIVKIKSILLNSLNRSHNLRHQINKNQFNNLINYSRFDENAFTYISLMRRNFDIQWKTEKLVLDSNTLFSRMGGLTSICIGLTAAVFAEFIEFLYWI-----HRSPFTNKTDSDSNHVRKE-----VYFQSQRLI--GFP-------VEENMFDFDRNEKANNIFMERSSSERCPSSFNDVNEELND 586
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000045131.1 (SMESG000045131.1) HSP 1 Score: 342.043 bits (876), Expect = 4.042e-109 Identity = 197/530 (37.17%), Postives = 315/530 (59.43%), Query Frame = 3 Query: 108 KPIMTDSNDIFSIFCATSSIRGMQKINKAQTPFLKVLWVGXXXXXXXXXXXXXXXXXKEYLGYYTAWHTSTKLEDQSLFPAITMCSHNPFSLKANNLWESKKIKSPNQFTKRLIYLNLIHLYDKISMVFDTM----VLRDEVQNFYTGLTVNETINLSHLKEFFQFCVVDVQHQKLVSRNCTGDLSEYLSVRM--FSHRNYFNCWTVE--PKKTMSGTFHDISS-----LIVVASLIPSSLIPELKDAFVMDILERGEGLKIVLHETGTYPDIDKDGFNIQPGKLNEIAYEPIKWKFLSTPVKICRDDQKEIIDLDRVFNYTFTQCVDAALQKXXXXXXXXXXXXWPRHKTPNEKFPYCFNVWRETVNEINETIICTSNFMNNMKARKLSVQMNKCFPRCNFFTYSTTLSITKWLPSIQKLDRIHRV----QQEVEMLVRNRTDKTFKDNFSSFLENKYQNYRNSLDNDSLNEDRFTYIKLIRKNKNTTIKIEKLILDVAILLSRIGGLCSLFIGLTVAFFIELIEFIYL 1646 KP+ ++FC SIRGMQKI +A FL+ +W+G+V T +L VT L +++ Y TAWHTST ++++ FPAI++CSHNPFS AN +W+ + +P +F + L ++ I+MV + +L D + +Y + ++NLSH +E ++CV+ ++ C DL+ Y++ R+ FS+ YFNC+T+E P+K + + +S+ +I++ + P S + ++ +FVMD L RG G+K+VLHE GT P+I+ G N+QPGK+NEI++E I W ++P + C ++Q IIDL + YT ++CV+A LQK ++ C C++S WPR P++ PYC N + + +EI + C+S + + K + KCF C++FTY T +S+T W PS+ KL+R+ ++ + +T++ K L+ K Q+ + N +E RFTYI ++RKN +T K E+L++D +I +SR+GGLCSL +GLT A F ELIEF YL Sbjct: 76 KPLANPQPSPLTLFCEAISIRGMQKIARAPNNFLRSVWIGYVILMTTLLTVTSYFLFRDFFNYNTAWHTSTAFDEKTEFPAISICSHNPFSENANRMWQENLVMTPKKFEELLTNVS-------INMVKNNRGGGEILYDSAEYYYGNIEYESSVNLSHKEEILRYCVLTTDAYVYIAEQC--DLASYVAYRLRKFSNSKYFNCFTIEEDPEKLKTHSADVVSTRELLSIIILIQITPESDLTQINSSFVMDTLTRGTGVKVVLHEVGTSPEIENYGINLQPGKMNEISFETIHWNRYNSPKRPCLNNQSNIIDLGNSYKYTMSKCVEAELQKSTIKNCGCMNSNWPRPVKPSQNIPYCTN-FSCSTDEILKRYECSS--IKDQGLTKQKLVDTKCFGVCSYFTYDTKVSVTNWKPSLYKLNRVTQIYKLANENYTETDEGKTERVKK------LKEKPQDTISKNLNMLTDESRFTYINVVRKNFDTIKKTERLVIDASIFMSRVGGLCSLLVGLTTAVFAELIEFCYL 587 The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 1
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30000964 ID=SMED30000964|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1962bpback to top protein sequence of SMED30000964-orf-1 >SMED30000964-orf-1 ID=SMED30000964-orf-1|Name=SMED30000964-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=633bp MSHKNNKRSSRITQFNSKPIMTDSNDIFSIFCATSSIRGMQKINKAQTPFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|