Homeobox domain-containing protein

Overview
NameHomeobox domain-containing protein
Smed IDSMED30000938
Length (bp)1645
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Homeobox domain-containing protein (SMED30000938) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox domain-containing protein (SMED30000938) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeobox domain-containing protein (SMED30000938) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeobox domain-containing protein (SMED30000938) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000938

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 13

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30000938h1SMcG0010872 SmedASXL_009006SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
X1 cellSMED30000938h1SMcG0010872 SmedASXL_009006SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Category 2 cellSMED30000938h1SMcG0010872 SMED30000938smed_20140614PMID:29100657
Cheng et al., 2018		whole organism asexual adult fluorescence in situ hybridization evidence
epidermisSMED30000938h1SMcG0010872 SMED30000938smed_20140614PMID:29100657
Cheng et al., 2018		whole organism asexual adult fluorescence in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30000938h1SMcG0010872 SMED30000938smed_20140614PMID:29100657
Cheng et al., 2018		whole organism asexual adult fluorescence in situ hybridization evidence
neoblastSMED30000938h1SMcG0010872 SMED30000938smed_20140614PMID:29100657
Cheng et al., 2018		whole organism asexual adult fluorescence in situ hybridization evidence
X1 cellSMED30000938h1SMcG0010872 SMED30000938smed_20140614PMID:29100657
Cheng et al., 2018		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30000938h1SMcG0010872 dd_Smed_v4_15471_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30000938h1SMcG0010872 dd_Smed_v4_15471_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000938h1SMcG0010872 dd_Smed_v4_15471_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30000938h1SMcG0010872 dd_Smed_v4_15471_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30000938h1SMcG0010872 dd_Smed_v6_15471_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
dorsal ventral margin of the whole animalSMED30000938h1SMcG0010872 dd_Smed_v4_15471_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX1 (SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887])

HSP 1 Score: 171.014 bits (432), Expect = 2.020e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX6 (SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892])

HSP 1 Score: 168.703 bits (426), Expect = 4.298e-48
Identity = 78/141 (55.32%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F+ GNY ELY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX2 (SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888])

HSP 1 Score: 168.703 bits (426), Expect = 1.862e-47
Identity = 75/139 (53.96%), Postives = 101/139 (72.66%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX3 (SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889])

HSP 1 Score: 166.777 bits (421), Expect = 2.320e-46
Identity = 77/141 (54.61%), Postives = 110/141 (78.01%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E+IL+++A   F++GN+ +LY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:  129 ESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 269
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX5 (SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891])

HSP 1 Score: 146.747 bits (369), Expect = 1.028e-39
Identity = 65/143 (45.45%), Postives = 93/143 (65.03%), Query Frame = 2 
Query:  419 QGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKN 847
            +G + +L+++A   F  G Y ELY+++E   F       LQ  +L+A Y EAE+ARG+ LG V+KYR+RKK+P+P +IWDG    +CF+E  R  L   Y  + +PT + K+ +++ TGLS+ QVSNWFKNRRQRDR   G  
Sbjct:   49 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGG 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-33 (Homeobox protein ceh-33 [Source:UniProtKB/Swiss-Prot;Acc:Q94166])

HSP 1 Score: 152.14 bits (383), Expect = 4.633e-42
Identity = 69/135 (51.11%), Postives = 97/135 (71.85%), Query Frame = 2 
Query:  434 ILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAI 838
            ILK++A   F+S N++ELY+IIE + F+ +    LQ +WL AHY EAEK RG+ LG V KYRIR+KYP+P +IWDG   S+CF+++ R  L   Y ++ +P+   K++++  T L+V QVSNWFKNRRQRDRA +
Sbjct:   58 ILKAQAFLAFHSNNFKELYRIIESHHFASEHHLPLQEWWLNAHYHEAEKIRGRQLGAVGKYRIRRKYPLPRTIWDGEETSYCFRDKSRVLLRDWYCRNSYPSPREKRELAEKTHLTVTQVSNWFKNRRQRDRAGV 192
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-32 (Homeobox protein ceh-32 [Source:UniProtKB/Swiss-Prot;Acc:Q23175])

HSP 1 Score: 154.066 bits (388), Expect = 4.843e-41
Identity = 79/147 (53.74%), Postives = 102/147 (69.39%), Query Frame = 2 
Query:  413 EEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRK 853
            E  G E  L+++A   F++ ++ ELY I+E N FS K   +LQ  W +AHY E EK RGK L  V+KYR+RKKYPMP +IWDG  K+HCF+E  R  L   YLKDP+P    KK++++ TGL+ MQV NWFKNRRQRDRAA  KN++
Sbjct:  103 EVAGNEAFLRARALVCFHASHFRELYAILENNKFSPKYHPKLQEMWHEAHYREQEKNRGKSLCAVDKYRVRKKYPMPRTIWDGEQKTHCFKERTRSLLREWYLKDPYPNPPKKKELANATGLTQMQVGNWFKNRRQRDRAAAAKNKQ 249
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-34 (Homeobox protein ceh-34 [Source:UniProtKB/Swiss-Prot;Acc:Q94165])

HSP 1 Score: 142.895 bits (359), Expect = 9.075e-39
Identity = 71/162 (43.83%), Postives = 105/162 (64.81%), Query Frame = 2 
Query:  419 QGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTK 904
            Q +E++LK++A  YF + N++ LYK++E + FS  +   LQ+ WL AHY+EA K + + LG V KYRIRKK P P +IWDG   ++CF+ + R  L   Y K  +P+   K+ ++  T LS++QVSNWFKN+RQR+RAA   +R  + SNDS   +    +K
Sbjct:   54 QVMESVLKAQALVYFTTQNWKMLYKLLECSKFSPHNHTVLQNLWLDAHYKEAAKTKDRELGAVCKYRIRKKNPFPNTIWDGEETNYCFKSKSRNVLRDAYKKCQYPSVEDKRRLAQQTELSIIQVSNWFKNKRQRERAAGQLDRSSARSNDSDDGSSGCESK 215
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: unc-39 (Homeobox protein unc-39 [Source:UniProtKB/Swiss-Prot;Acc:O17894])

HSP 1 Score: 116.316 bits (290), Expect = 1.712e-28
Identity = 54/136 (39.71%), Postives = 84/136 (61.76%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLK-DPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRA 832
            E I+ +     ++S  +E L+ ++    F ++    LQ  W  A Y+E++  RGK L PVEKYR+R+K+P P +IWDG    + F++  RKFL   +     +PT   K+++S  TGL ++Q+SNWFKNRRQRD++
Sbjct:  140 EAIIVAYTYALYHSNEFETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKRGKELNPVEKYRLRRKFPAPKTIWDGEEIVYSFKDSSRKFLKQFFRNVSEYPTQEQKREISRATGLKIVQISNWFKNRRQRDKS 275
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: so (gene:FBgn0003460 transcript:FBtr0088970)

HSP 1 Score: 169.859 bits (429), Expect = 6.185e-47
Identity = 77/154 (50.00%), Postives = 110/154 (71.43%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKN-----RKLSESNDS 874
            E++LK+KA   F+ G Y+ELY+++E + FS ++  +LQ+ WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K+D++  TGL+  QVSNWFKNRRQRDRAA  K+     + L  S+DS
Sbjct:  141 ESVLKAKAVVAFHRGQYKELYRLLEHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDGSTDKQHLDSSSDS 294
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Optix (gene:FBgn0025360 transcript:FBtr0088865)

HSP 1 Score: 159.844 bits (403), Expect = 1.073e-42
Identity = 78/149 (52.35%), Postives = 106/149 (71.14%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDS 874
            E +L+++A   ++ GN+ ELY IIE + F++ S  +LQ+ WL+AHY EAEK RG+ LGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P    K++++  TGL+  QV NWFKNRRQRDRAA  KNR     N S
Sbjct:   79 EAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSS 227
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Optix (gene:FBgn0025360 transcript:FBtr0329885)

HSP 1 Score: 159.844 bits (403), Expect = 1.166e-42
Identity = 78/149 (52.35%), Postives = 106/149 (71.14%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDS 874
            E +L+++A   ++ GN+ ELY IIE + F++ S  +LQ+ WL+AHY EAEK RG+ LGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P    K++++  TGL+  QV NWFKNRRQRDRAA  KNR     N S
Sbjct:   79 EAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSS 227
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Six4 (gene:FBgn0027364 transcript:FBtr0078274)

HSP 1 Score: 154.066 bits (388), Expect = 2.034e-41
Identity = 68/134 (50.75%), Postives = 96/134 (71.64%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDR 829
            E++L+++A   +  G + ELY ++E + FS K    LQ+ W +AHY+EAEK RG+PLG V+KYR+RKKYP+P +IWDG    +CF+E+ R  L   YL + +PT + KK ++  TGL++ QVSNWFKNRRQRDR
Sbjct:  219 ESVLRARAMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR 352
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Six4 (gene:FBgn0027364 transcript:FBtr0078275)

HSP 1 Score: 154.066 bits (388), Expect = 2.034e-41
Identity = 68/134 (50.75%), Postives = 96/134 (71.64%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDR 829
            E++L+++A   +  G + ELY ++E + FS K    LQ+ W +AHY+EAEK RG+PLG V+KYR+RKKYP+P +IWDG    +CF+E+ R  L   YL + +PT + KK ++  TGL++ QVSNWFKNRRQRDR
Sbjct:  219 ESVLRARAMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR 352
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six7 (SIX homeobox 7 [Source:ZFIN;Acc:ZDB-GENE-990825-28])

HSP 1 Score: 182.185 bits (461), Expect = 3.863e-53
Identity = 76/141 (53.90%), Postives = 105/141 (74.47%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++++++A   F+ GN+E LY+I++ + F+ +S  +LQ  WL AHY EAE+ RG+PLGPVEKYRIRKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K+ ++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVMRARALVAFHGGNFEALYQILQSHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six1b (SIX homeobox 1b [Source:NCBI gene;Acc:404627])

HSP 1 Score: 175.252 bits (443), Expect = 2.729e-50
Identity = 79/152 (51.97%), Postives = 110/152 (72.37%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ SE+N++  N
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNTGAN 198
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six2a (SIX homeobox 2a [Source:ZFIN;Acc:ZDB-GENE-010412-1])

HSP 1 Score: 171.014 bits (432), Expect = 1.307e-48
Identity = 76/141 (53.90%), Postives = 102/141 (72.34%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER 187
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six2a (SIX homeobox 2a [Source:ZFIN;Acc:ZDB-GENE-010412-1])

HSP 1 Score: 171.014 bits (432), Expect = 1.307e-48
Identity = 76/141 (53.90%), Postives = 102/141 (72.34%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER 187
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six2b (SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-23])

HSP 1 Score: 170.629 bits (431), Expect = 1.919e-48
Identity = 77/152 (50.66%), Postives = 107/152 (70.39%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            E++LK+KA   F+ GN+ ELYK++E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+   +N +  N
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKVLESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRCVLKEWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENEGANPNGHN 198
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six1 (SIX homeobox 1 [Source:NCBI gene;Acc:100101702])

HSP 1 Score: 170.244 bits (430), Expect = 3.592e-48
Identity = 75/141 (53.19%), Postives = 102/141 (72.34%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER 187
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six2 (SIX homeobox 2 [Source:NCBI gene;Acc:100101784])

HSP 1 Score: 169.088 bits (427), Expect = 9.803e-48
Identity = 75/139 (53.96%), Postives = 101/139 (72.66%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILEGHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six6 (SIX homeobox 6 [Source:NCBI gene;Acc:100101705])

HSP 1 Score: 166.007 bits (419), Expect = 4.216e-47
Identity = 77/141 (54.61%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F++GN+ ELY I+E + F++ S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVLRARAIVAFHTGNFRELYHILENHKFTKDSHTKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: tmem136 (transmembrane protein 136 [Source:Xenbase;Acc:XB-GENE-966251])

HSP 1 Score: 167.162 bits (422), Expect = 6.984e-47
Identity = 77/141 (54.61%), Postives = 110/141 (78.01%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E+IL+++A   F++GN+ +LY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   91 ESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 231
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: SIX4 (SIX homeobox 4 [Source:NCBI gene;Acc:100498150])

HSP 1 Score: 151.754 bits (382), Expect = 2.716e-38
Identity = 66/137 (48.18%), Postives = 95/137 (69.34%), Query Frame = 2 
Query:  419 QGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDR 829
            +G E+ILK++A   F+ G Y EL+ ++E + F   +   LQ  W +A Y EAEKARG+PLG V+KYR+R+K+P+P +IWDG    +CF+E+ R  L   Y  + +P+   K++++  TGLS+ QVSNWFKNRRQRDR
Sbjct:  185 RGNESILKARALVTFHQGRYSELFLLLESHNFHPSNHAALQELWYKARYIEAEKARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKHNRYPSPAAKRNLAKVTGLSLTQVSNWFKNRRQRDR 321
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six1 (sine oculis-related homeobox 1 [Source:MGI Symbol;Acc:MGI:102780])

HSP 1 Score: 171.014 bits (432), Expect = 1.225e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six6 (sine oculis-related homeobox 6 [Source:MGI Symbol;Acc:MGI:1341840])

HSP 1 Score: 167.548 bits (423), Expect = 7.670e-48
Identity = 78/141 (55.32%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F+ GNY ELY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six2 (sine oculis-related homeobox 2 [Source:MGI Symbol;Acc:MGI:102778])

HSP 1 Score: 169.088 bits (427), Expect = 1.039e-47
Identity = 75/139 (53.96%), Postives = 101/139 (72.66%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six2 (sine oculis-related homeobox 2 [Source:MGI Symbol;Acc:MGI:102778])

HSP 1 Score: 169.088 bits (427), Expect = 1.039e-47
Identity = 75/139 (53.96%), Postives = 101/139 (72.66%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six3 (sine oculis-related homeobox 3 [Source:MGI Symbol;Acc:MGI:102764])

HSP 1 Score: 167.162 bits (422), Expect = 1.429e-46
Identity = 77/141 (54.61%), Postives = 110/141 (78.01%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E+IL+++A   F++GN+ +LY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:  130 ESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 270
[Close]
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NZ04|SIX1B_DANRE (Homeobox protein six1b OS=Danio rerio OX=7955 GN=six1b PE=1 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 2.060e-49
Identity = 79/152 (51.97%), Postives = 110/152 (72.37%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ SE+N++  N
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNTGAN 198
[Close]
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q62231|SIX1_MOUSE (Homeobox protein SIX1 OS=Mus musculus OX=10090 GN=Six1 PE=1 SV=2)

HSP 1 Score: 171.014 bits (432), Expect = 8.567e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|A2D5H2|SIX1_LAGLA (Homeobox protein SIX1 OS=Lagothrix lagotricha OX=9519 GN=SIX1 PE=3 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 9.602e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q15475|SIX1_HUMAN (Homeobox protein SIX1 OS=Homo sapiens OX=9606 GN=SIX1 PE=1 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 9.702e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|A1YER0|SIX1_GORGO (Homeobox protein SIX1 OS=Gorilla gorilla gorilla OX=9595 GN=SIX1 PE=3 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 9.702e-48
Identity = 76/145 (52.41%), Postives = 105/145 (72.41%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSE 862
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ +E
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTE 191
[Close]
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A183AH06 (Homeobox domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS6241 PE=4 SV=1)

HSP 1 Score: 186.037 bits (471), Expect = 5.144e-52
Identity = 79/136 (58.09%), Postives = 107/136 (78.68%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAA 835
            E IL+++A   F++GN+ ELY I+ER+TF + S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+PMP +IWDG  K+HCF+E  R  L   YL+DP+P+   K++++S TGL+  QV NWFKNRRQRDRAA
Sbjct:   47 EVILRARALVAFHTGNFRELYAILERHTFPKSSHVKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRGLLREWYLQDPYPSPAKKRELASATGLTPTQVGNWFKNRRQRDRAA 182
[Close]
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A0P7Y6B7 (Homeobox protein SIX6-like OS=Scleropages formosus OX=113540 GN=Z043_120673 PE=4 SV=1)

HSP 1 Score: 188.348 bits (477), Expect = 5.608e-52
Identity = 78/141 (55.32%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F++GN+ ELY I+E + FS+ S  +LQ+ WL++HY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  N K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   75 ESVLRARAIVAFHTGNFSELYHILENHKFSKDSHSKLQALWLESHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPNKKRELAQATGLTPTQVGNWFKNRRQRDRAAATKNR 215
[Close]
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: V3Z5W5 (Homeobox domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_179424 PE=4 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 1.491e-51
Identity = 78/141 (55.32%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E+IL+S++   F++GN+ +LY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKKYP+P +IWDG  K+HCF+E  R  L   YL+DP+P    K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESILRSRSLVSFHTGNFRDLYHILENHKFTKESHAKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKYPLPRTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPTKKRELAQATGLTPTQVGNWFKNRRQRDRAAATKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A3Q3JQY5 (SIX homeobox 7 OS=Monopterus albus OX=43700 PE=4 SV=1)

HSP 1 Score: 186.037 bits (471), Expect = 3.102e-51
Identity = 86/209 (41.15%), Postives = 129/209 (61.72%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAI---------KELAQIQSSNQTRFKGFNIADLCVENETK 1027
            E++++++A   F+ GN+E LY+I++ + F+ +S  +LQ  WL AHY EAE+ RG+PLGPVEKYRIRKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K+ ++  TGL+  QV NWFKNRRQRDRAA  KNR   + + S   +       LP + HH   +          E +   +  + R  G +  D+ V ++++
Sbjct:   51 ESVMRARALVAFHGGNFEALYQILQSHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNRL--QQDPSLLPSESSPDGSLPERRHHPRLLPTSPRHPGSPEASDCSTETERRGTGASTPDISVSSDSE 257
[Close]
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A484C713 (Homeobox domain-containing protein OS=Perca flavescens OX=8167 GN=EPR50_G00196120 PE=4 SV=1)

HSP 1 Score: 186.037 bits (471), Expect = 3.201e-51
Identity = 86/209 (41.15%), Postives = 130/209 (62.20%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAI---------KELAQIQSSNQTRFKGFNIADLCVENETK 1027
            E++++++A   F+ GN+E LY+I++ + F+ +S  +LQ  WL AHY EAE+ RG+PLGPVEKYRIRKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K+ ++  TGL+  QV NWFKNRRQRDRAA  KNR   + + S   +G      L  + HH   +          E +   + N+ R  G +  ++ V ++++
Sbjct:   51 ESVMRARALVAFHGGNFEGLYQILQSHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNRM--QQDPSLLPSGSSPDGSLQDRCHHPHLLPPSPRHLGSPEASDCSTENERRGTGASTPEISVSSDSE 257
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six7 (homeobox protein SIX6-like [Source:NCBI gene;Acc:103038426])

HSP 1 Score: 182.57 bits (462), Expect = 2.645e-53
Identity = 76/141 (53.90%), Postives = 105/141 (74.47%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++++++A   F+ GN+E LY+I++ + F+ +S  +LQ  WL AHY EAE+ RG+PLGPVEKYRIRKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K+ ++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVMRARALVAFHGGNFEALYQILQNHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six1b (homeobox protein six1b [Source:NCBI gene;Acc:103034839])

HSP 1 Score: 176.407 bits (446), Expect = 9.855e-51
Identity = 80/152 (52.63%), Postives = 110/152 (72.37%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ SE+N+S  N
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNSGAN 198
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six9 (homeobox protein SIX2-like [Source:NCBI gene;Acc:111191018])

HSP 1 Score: 173.326 bits (438), Expect = 7.185e-50
Identity = 77/155 (49.68%), Postives = 106/155 (68.39%), Query Frame = 2 
Query:  419 QGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            QG+E++LK++A   F+ G + ELY +IE + FS  S   LQ  WL+AHY EAE  RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y + P+P+   K+D+++ TGL+  QVSNWFKNRRQRDRAA G+     +  DS Q 
Sbjct:   50 QGMESVLKARAAVAFHQGRFTELYALIEGHAFSPLSHALLQQLWLRAHYLEAELQRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRCVLREWYCRKPYPSPREKRDLAAATGLTATQVSNWFKNRRQRDRAAQGRK---GQGEDSLQQ 201
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six2a (SIX homeobox 2 [Source:NCBI gene;Acc:103025828])

HSP 1 Score: 171.014 bits (432), Expect = 1.203e-48
Identity = 76/141 (53.90%), Postives = 102/141 (72.34%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER 187
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000021946.2 (homeobox protein six1b [Source:NCBI gene;Acc:103045548])

HSP 1 Score: 170.244 bits (430), Expect = 1.914e-48
Identity = 75/142 (52.82%), Postives = 103/142 (72.54%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRK 853
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAE+ RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGLS  QVSNWFKNRRQRDRAA  K R+
Sbjct:   47 ESVLKAKAMVAFHRGNFRELYKILEGHQFSTHNHGKLQQLWLRAHYAEAERLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYTHNPYPSPREKRELAQATGLSTTQVSNWFKNRRQRDRAAEAKERE 188
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002854.1 (pep scaffold:Pmarinus_7.0:GL480305:17375:18769:1 gene:ENSPMAG00000002608.1 transcript:ENSPMAT00000002854.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 160.999 bits (406), Expect = 2.348e-46
Identity = 76/141 (53.90%), Postives = 105/141 (74.47%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E +L+++A   F++ NY +LY I+E + FS+ S  +LQ+ WL+AHY EAE+ RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P    K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   83 EAVLRARAVVAFHASNYRDLYAILEGHKFSKASHAKLQAMWLEAHYLEAERLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 223
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: six1a (SIX homeobox 1a [Source:NCBI gene;Acc:494168])

HSP 1 Score: 145.976 bits (367), Expect = 1.037e-41
Identity = 65/133 (48.87%), Postives = 92/133 (69.17%), Query Frame = 2 
Query:  419 QGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRR 817
            Q  E+IL +KA   F+ GN+ ELY ++E   FS ++  +LQ  WL+AHY EAE+ RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E  R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRR
Sbjct:   18 QRSESILMAKAVVAFHQGNFRELYAVLESQPFSARNHPKLQQLWLKAHYTEAERLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKERSRGVLRDWYAHNPYPSPREKRELAQATGLTTTQVSNWFKNRR 150
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011157.1 (pep scaffold:Pmarinus_7.0:GL488016:7246:7434:-1 gene:ENSPMAG00000010130.1 transcript:ENSPMAT00000011157.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 82.4185 bits (202), Expect = 5.826e-20
Identity = 32/63 (50.79%), Postives = 45/63 (71.43%), Query Frame = 2 
Query:  629 KYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRR 817
            K+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRR
Sbjct:    1 KFPLPKTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 63
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: Six4 (pep scaffold:Pmarinus_7.0:GL478660:19078:19268:1 gene:ENSPMAG00000010180.1 transcript:ENSPMAT00000011207.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Six4)

HSP 1 Score: 72.0182 bits (175), Expect = 2.493e-16
Identity = 31/63 (49.21%), Postives = 44/63 (69.84%), Query Frame = 2 
Query:  629 KYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRR 817
            K+P+P +IWDG    +CF+E+ R FL   Y +  +P  + K+ ++  TGLSV+QVSNWFKNRR
Sbjct:    1 KFPLPRTIWDGEETVYCFKEKSRNFLKDCYRRTRYPAPDEKRRLAKLTGLSVVQVSNWFKNRR 63
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO34334 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPN4])

HSP 1 Score: 167.162 bits (422), Expect = 4.957e-49
Identity = 75/141 (53.19%), Postives = 103/141 (73.05%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++LK+KA   F+  N++ELY+I+E N FS  +  +LQS WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R
Sbjct:   45 ESVLKAKAIVSFHQQNFQELYRILENNNFSPNAHPKLQSLWLKAHYMEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRNILREWYSHNPYPSPREKRELAEGTGLTTTQVSNWFKNRRQRDRAAEAKIR 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO33059 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST96])

HSP 1 Score: 162.155 bits (409), Expect = 4.903e-47
Identity = 75/141 (53.19%), Postives = 107/141 (75.89%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F+ GN+ +LY I+E + F+ +S  +LQ+ WL+AHY+EAE+ RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P    K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   52 ESVLRARAIVAFHMGNFRDLYHILETHRFTRESHAKLQAMWLEAHYQEAERLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 192
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO42933 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S005])

HSP 1 Score: 153.295 bits (386), Expect = 7.172e-44
Identity = 68/141 (48.23%), Postives = 94/141 (66.67%), Query Frame = 2 
Query:  413 EEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAA 835
            E    ETIL +KA   F+  N++ELY I+E   F     ++LQ  W  AHY EAE+ RG+PLG V KYR+R+K+P+P +IWDG   ++CF+E+ R  L+  Y+  P+PT   K +++  T L+V QVSNWFKN+RQR RAA
Sbjct:   37 EIHACETILVAKAVVAFHQNNFKELYSILESRKFQRSEHEKLQCLWRTAHYIEAERVRGRPLGAVGKYRVRRKFPLPRTIWDGEETTYCFKEKSRSILNKAYVDSPYPTPREKHELAKMTDLTVTQVSNWFKNKRQRVRAA 177
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO31034 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ27])

HSP 1 Score: 147.132 bits (370), Expect = 1.259e-41
Identity = 67/136 (49.26%), Postives = 93/136 (68.38%), Query Frame = 2 
Query:  422 GLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDR 829
            G E++LK++A   F+ G Y E+Y I+E N F   S + LQ  W +AHY EAEK RG+ LG V+KYRIR+K+P+P +IWDG    +CF+E+ R  L   Y ++ +PT   K+ ++  T L++ QVSNWFKNRRQRDR
Sbjct:   34 GSESVLKARAIVSFHRGRYREVYNILETNEFDPSSHELLQCLWYKAHYSEAEKLRGRSLGAVDKYRIRRKFPLPRTIWDGEETVYCFKEKARAALKDCYEQNKYPTPQEKRLIAKQTNLTLKQVSNWFKNRRQRDR 169
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO33407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SS98])

HSP 1 Score: 118.242 bits (295), Expect = 3.402e-31
Identity = 56/130 (43.08%), Postives = 83/130 (63.85%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRR 817
            E++LK++A   F+ G Y+E+Y I+E N F   S + LQ  W +AHY E EK RG+ L  V+K+RIRKK P+P +I DG    + F+E++R  L   Y    +PT   K+ +++ T L++ QV NWF+NRR
Sbjct:   36 ESLLKARAMVAFHRGCYQEVYNILENNKFDTSSHEFLQCLWYKAHYSEGEKLRGRSLSAVDKFRIRKKSPLPNTISDGEKTIYFFKEKVRTVLKECYEHKKYPTLKEKRVIATQTNLTLRQVRNWFRNRR 165
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six7 (homeobox protein SIX6-like [Source:NCBI gene;Acc:101175353])

HSP 1 Score: 183.341 bits (464), Expect = 1.160e-53
Identity = 89/202 (44.06%), Postives = 125/202 (61.88%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAIKELAQIQSSNQTRFKGFNIADLCVENETKNT 1033
            E++++++A   F+ GN+E LY+I++ + F+ +S  +LQ  WL AHY EAE+ RG+PLGPVEKYRIRKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K+ ++  TGL+  QV NWFKNRRQRDRAA  KNR L +      + G  ST     + HH + +    Q   S +        +D   ENE   T
Sbjct:   51 ESVMRARALVAFHVGNFEALYQILQSHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNR-LQQDPSLLPSEG--STDGFQERQHHSQRLPASPQHPGSPEA-------SDCSTENERVGT 242
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six1b (SIX homeobox 1 [Source:NCBI gene;Acc:101175523])

HSP 1 Score: 175.637 bits (444), Expect = 1.886e-50
Identity = 79/152 (51.97%), Postives = 110/152 (72.37%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQN 883
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P +IWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K R+ SE+N++  N
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNAGGN 198
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six2a (SIX homeobox 2 [Source:NCBI gene;Acc:101161260])

HSP 1 Score: 169.088 bits (427), Expect = 6.158e-48
Identity = 75/139 (53.96%), Postives = 101/139 (72.66%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E++LK+KA   F+ GN+ ELYKI+E + FS  +  +LQ  WL+AHY EAEK RG+PLG V KYR+R+K+P+P SIWDG   S+CF+E+ R  L   Y  +P+P+   K++++  TGL+  QVSNWFKNRRQRDRAA  K
Sbjct:   47 ESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAK 185
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six6a (SIX homeobox 6 [Source:NCBI gene;Acc:101154821])

HSP 1 Score: 167.162 bits (422), Expect = 8.901e-48
Identity = 77/141 (54.61%), Postives = 110/141 (78.01%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E++L+++A   F++GN+ ELY I+E + F+++S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:   51 ESVLRARAVVAFHTGNFRELYHILENHKFTKESHTKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 191
[Close]
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six3 (SIX homeobox 3 [Source:NCBI gene;Acc:100144381])

HSP 1 Score: 166.777 bits (421), Expect = 1.109e-46
Identity = 77/141 (54.61%), Postives = 109/141 (77.30%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNR 850
            E+IL+++A   F++GN+ +LY I+E + F++ S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+P+P +IWDG  K+HCF+E  R  L   YL+DP+P  + K++++  TGL+  QV NWFKNRRQRDRAA  KNR
Sbjct:  120 ESILRARAVVAFHTGNFRDLYHILENHKFTKDSHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNR 260
[Close]
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000060967.1 (SMESG000060967.1)

HSP 1 Score: 543.502 bits (1399), Expect = 0.000e+0
Identity = 260/260 (100.00%), Postives = 260/260 (100.00%), Query Frame = 2 
Query:  380 MTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAIKELAQIQSSNQTRFKGFNIADLCVENETKNTDINMAKHPIIFNNLSNINAHMYFNYYFLNALRENNCIENLFL 1159
            MTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAIKELAQIQSSNQTRFKGFNIADLCVENETKNTDINMAKHPIIFNNLSNINAHMYFNYYFLNALRENNCIENLFL
Sbjct:    1 MTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAIKELAQIQSSNQTRFKGFNIADLCVENETKNTDINMAKHPIIFNNLSNINAHMYFNYYFLNALRENNCIENLFL 260
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000017729.1 (SMESG000017729.1)

HSP 1 Score: 190.66 bits (483), Expect = 3.777e-54
Identity = 87/168 (51.79%), Postives = 122/168 (72.62%), Query Frame = 2 
Query:  377 TMTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRK--LSESNDS 874
            +M T S +   L E   E +L+++A   F++GN+ ELY I+E++ F + S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+PMP +IWDG  K+HCF+E  R  L   YL+DP+P    K++++S TGL+  QV NWFKNRRQRDRAA  K+R+  LS+ +DS
Sbjct:   67 SMPTNSILWKSLNEH--EALLRARAIVAFHTGNFRELYHILEKHHFEKSSHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELASATGLTPTQVGNWFKNRRQRDRAAASKHRRILLSDEDDS 232
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000017729.1 (SMESG000017729.1)

HSP 1 Score: 190.66 bits (483), Expect = 4.992e-54
Identity = 87/168 (51.79%), Postives = 122/168 (72.62%), Query Frame = 2 
Query:  377 TMTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKNRK--LSESNDS 874
            +M T S +   L E   E +L+++A   F++GN+ ELY I+E++ F + S  +LQ+ WL+AHY+EAEK RG+PLGPV+KYR+RKK+PMP +IWDG  K+HCF+E  R  L   YL+DP+P    K++++S TGL+  QV NWFKNRRQRDRAA  K+R+  LS+ +DS
Sbjct:   74 SMPTNSILWKSLNEH--EALLRARAIVAFHTGNFRELYHILEKHHFEKSSHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELASATGLTPTQVGNWFKNRRQRDRAAASKHRRILLSDEDDS 239
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000020326.1 (SMESG000020326.1)

HSP 1 Score: 182.956 bits (463), Expect = 1.094e-53
Identity = 78/139 (56.12%), Postives = 105/139 (75.54%), Query Frame = 2 
Query:  428 ETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGK 844
            E+IL++++   F+SGNY ELY I+E + FS +S  +LQSFW  AHY EAEK RG+ LGPV+KYR+RK++P+P +IWDG  ++HCFQE  R  L   Y KDP+P  N K++++  TGL+  QV NWFKNRRQRDRAA+G+
Sbjct:   65 ESILRARSIVAFHSGNYAELYFILENHRFSSQSHMKLQSFWFDAHYSEAEKLRGRALGPVDKYRVRKRHPLPSTIWDGQQRTHCFQERTRCLLKDCYSKDPYPNPNKKRELAIRTGLTATQVGNWFKNRRQRDRAALGR 203
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000009894.1 (SMESG000009894.1)

HSP 1 Score: 165.622 bits (418), Expect = 3.937e-46
Identity = 85/166 (51.20%), Postives = 120/166 (72.29%), Query Frame = 2 
Query:  377 TMTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSRKQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHCFQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDRAAIGKN-RKLSESND 871
            ++ + SS+   L  Q  E+I +++A   F+ GN+ ELY +IE+N F++ S  +LQ+ WL+AHY+EAE+ RG+ LGPV+KYR+RKK+PMP +IWDG  K+HCF+E  R  L   YL DP+P  + K+ ++S TGL+  QV NWFKNRRQRDRAA  KN R++S+S D
Sbjct:   47 SLPSFSSLWDSLSRQ--ESIQRARALVAFHVGNFRELYNLIEKNRFTKASHSKLQALWLEAHYQEAERLRGRSLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRNLLRECYLDDPYPNPSKKRQLASATGLTPTQVGNWFKNRRQRDRAAAAKNGRQMSQSED 210
The following BLAST results are available for this feature:
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SIX12.020e-4852.41SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887][more]
SIX64.298e-4855.32SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892][more]
SIX21.862e-4753.96SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888][more]
SIX32.320e-4654.61SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889][more]
SIX51.028e-3945.45SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891][more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ceh-334.633e-4251.11Homeobox protein ceh-33 [Source:UniProtKB/Swiss-P... [more]
ceh-324.843e-4153.74Homeobox protein ceh-32 [Source:UniProtKB/Swiss-P... [more]
ceh-349.075e-3943.83Homeobox protein ceh-34 [Source:UniProtKB/Swiss-P... [more]
unc-391.712e-2839.71Homeobox protein unc-39 [Source:UniProtKB/Swiss-P... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
so6.185e-4750.00gene:FBgn0003460 transcript:FBtr0088970[more]
Optix1.073e-4252.35gene:FBgn0025360 transcript:FBtr0088865[more]
Optix1.166e-4252.35gene:FBgn0025360 transcript:FBtr0329885[more]
Six42.034e-4150.75gene:FBgn0027364 transcript:FBtr0078274[more]
Six42.034e-4150.75gene:FBgn0027364 transcript:FBtr0078275[more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six73.863e-5353.90SIX homeobox 7 [Source:ZFIN;Acc:ZDB-GENE-990825-28... [more]
six1b2.729e-5051.97SIX homeobox 1b [Source:NCBI gene;Acc:404627][more]
six2a1.307e-4853.90SIX homeobox 2a [Source:ZFIN;Acc:ZDB-GENE-010412-1... [more]
six2a1.307e-4853.90SIX homeobox 2a [Source:ZFIN;Acc:ZDB-GENE-010412-1... [more]
six2b1.919e-4850.66SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-2... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six13.592e-4853.19SIX homeobox 1 [Source:NCBI gene;Acc:100101702][more]
six29.803e-4853.96SIX homeobox 2 [Source:NCBI gene;Acc:100101784][more]
six64.216e-4754.61SIX homeobox 6 [Source:NCBI gene;Acc:100101705][more]
tmem1366.984e-4754.61transmembrane protein 136 [Source:Xenbase;Acc:XB-G... [more]
SIX42.716e-3848.18SIX homeobox 4 [Source:NCBI gene;Acc:100498150][more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Six11.225e-4852.41sine oculis-related homeobox 1 [Source:MGI Symbol;... [more]
Six67.670e-4855.32sine oculis-related homeobox 6 [Source:MGI Symbol;... [more]
Six21.039e-4753.96sine oculis-related homeobox 2 [Source:MGI Symbol;... [more]
Six21.039e-4753.96sine oculis-related homeobox 2 [Source:MGI Symbol;... [more]
Six31.429e-4654.61sine oculis-related homeobox 3 [Source:MGI Symbol;... [more]
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BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6NZ04|SIX1B_DANRE2.060e-4951.97Homeobox protein six1b OS=Danio rerio OX=7955 GN=s... [more]
sp|Q62231|SIX1_MOUSE8.567e-4852.41Homeobox protein SIX1 OS=Mus musculus OX=10090 GN=... [more]
sp|A2D5H2|SIX1_LAGLA9.602e-4852.41Homeobox protein SIX1 OS=Lagothrix lagotricha OX=9... [more]
sp|Q15475|SIX1_HUMAN9.702e-4852.41Homeobox protein SIX1 OS=Homo sapiens OX=9606 GN=S... [more]
sp|A1YER0|SIX1_GORGO9.702e-4852.41Homeobox protein SIX1 OS=Gorilla gorilla gorilla O... [more]
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BLAST of Homeobox domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183AH065.144e-5258.09Homeobox domain-containing protein OS=Echinostoma ... [more]
A0A0P7Y6B75.608e-5255.32Homeobox protein SIX6-like OS=Scleropages formosus... [more]
V3Z5W51.491e-5155.32Homeobox domain-containing protein OS=Lottia gigan... [more]
A0A3Q3JQY53.102e-5141.15SIX homeobox 7 OS=Monopterus albus OX=43700 PE=4 S... [more]
A0A484C7133.201e-5141.15Homeobox domain-containing protein OS=Perca flaves... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six72.645e-5353.90homeobox protein SIX6-like [Source:NCBI gene;Acc:1... [more]
six1b9.855e-5152.63homeobox protein six1b [Source:NCBI gene;Acc:10303... [more]
six97.185e-5049.68homeobox protein SIX2-like [Source:NCBI gene;Acc:1... [more]
six2a1.203e-4853.90SIX homeobox 2 [Source:NCBI gene;Acc:103025828][more]
ENSAMXT00000021946.21.914e-4852.82homeobox protein six1b [Source:NCBI gene;Acc:10304... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSPMAT00000002854.12.348e-4653.90pep scaffold:Pmarinus_7.0:GL480305:17375:18769:1 g... [more]
six1a1.037e-4148.87SIX homeobox 1a [Source:NCBI gene;Acc:494168][more]
ENSPMAT00000011157.15.826e-2050.79pep scaffold:Pmarinus_7.0:GL488016:7246:7434:-1 ge... [more]
Six42.493e-1649.21pep scaffold:Pmarinus_7.0:GL478660:19078:19268:1 g... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO343344.957e-4953.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO330594.903e-4753.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO429337.172e-4448.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO310341.259e-4149.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO334073.402e-3143.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six71.160e-5344.06homeobox protein SIX6-like [Source:NCBI gene;Acc:1... [more]
six1b1.886e-5051.97SIX homeobox 1 [Source:NCBI gene;Acc:101175523][more]
six2a6.158e-4853.96SIX homeobox 2 [Source:NCBI gene;Acc:101161260][more]
six6a8.901e-4854.61SIX homeobox 6 [Source:NCBI gene;Acc:101154821][more]
six31.109e-4654.61SIX homeobox 3 [Source:NCBI gene;Acc:100144381][more]
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000060967.10.000e+0100.00SMESG000060967.1[more]
SMESG000017729.13.777e-5451.79SMESG000017729.1[more]
SMESG000017729.14.992e-5451.79SMESG000017729.1[more]
SMESG000020326.11.094e-5356.12SMESG000020326.1[more]
SMESG000009894.13.937e-4651.20SMESG000009894.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000938 ID=SMED30000938|Name=Homeobox domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1645bp
GATGAACAGCTGAGATTGCTTACTCCTCAACACCAGCTACTGACTTCATT
AAACAAACATATCAGTGTCTAGAAATGGTTTCAACTAATTCTTGGTTGAT
GAGGTTGAATGACGACTAAGCTTTACCTAATGTTATAATTTTTTAAGGCC
TTAATTAGGTAATTTACTGACACTTCAACTGTAGCAAAACACATTTTATT
TTATTATTTGCGATTTACACACATCATTATTATTCCAACATTTTCTTCAA
ACAATGGTGACCACTCACACAATGCGAACACCGCTCCAGCCAATCAGAAT
TCTCTGAAACATCAATGGCTTATTTCACGCTGAATTTCTGTTATAAATTT
AAATTTCAAACAACAACAACGATGAGACTATGACTACGCAAAGTTCTATT
GATTCAAAATTGGAGGAACAGGGATTGGAAACAATATTGAAATCCAAGGC
GACAAATTATTTTTATTCGGGAAATTATGAAGAGTTATATAAAATTATTG
AGCGGAATACGTTCAGTGAAAAATCAAGAAAACAACTTCAAAGCTTTTGG
TTGCAAGCTCACTATGAAGAAGCGGAAAAGGCTCGTGGTAAACCTTTGGG
CCCTGTTGAGAAATATAGGATCAGGAAAAAATATCCAATGCCCATTAGTA
TTTGGGATGGCACTAATAAAAGTCATTGTTTTCAAGAGGAAATCAGAAAA
TTTTTGCATCATAAATACTTGAAAGATCCCTTTCCGACGTCAAATATGAA
AAAAGATATGTCTAGTTTTACCGGACTTAGTGTAATGCAGGTTTCTAATT
GGTTCAAGAATCGCCGACAGCGAGACAGAGCTGCAATTGGTAAAAACAGG
AAGCTTTCAGAATCAAATGATTCTTTTCAAAACGCAGGCAAACTCTCGAC
AAAAGAATTGCCAATTCAAATGCATCATGTAGAAGCAATTAAAGAACTGG
CTCAAATCCAAAGTTCCAATCAAACAAGATTCAAAGGATTTAATATTGCT
GATTTGTGTGTAGAGAATGAGACCAAAAACACCGACATAAATATGGCAAA
GCATCCAATAATCTTTAATAATTTATCCAACATAAATGCGCACATGTATT
TTAATTATTATTTCCTGAACGCACTCCGTGAAAATAATTGTATAGAAAAT
TTATTTTTGTAATAATGAAATTATTTAAGAACCATTTTTTGTCTATTTAT
AAAATTTTTAAAAATTATTTTTAATAAAATCCAATTAATTGAAGAAAATA
CGTCAGGAAATGATGTCATTGTGATTACAGTAAAACCCGATAAACGCGAA
ATCCAGTGGACTTACAAAACATGTTCACTGGCGTTATGATTTTTCAGCAT
TTTTTTTCAACCGAAAGTTTTCCCTTGATGTTTCTACCGATGAATTCATT
ACTTTTTTAAAAGAAAAACTTGGAAAAATTTCGCGCACACATCAGTTTTT
TAATATAAGCTTTTTTTATTGCCGAGAAATATGGACTACGCTACGGGATT
CCAGTTATGGACAAACTATTAAAAACCTGCGTTGGAGAAATGATAAAATT
TCATAGGCTATATCAGTGTTTCCCAAACTTTCGATCAATGAGTACCCCTT
TCTCATTTTTTTGACACTTTGTACCAGTAAGAAGAAAATTTCTAA
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protein sequence of SMED30000938-orf-1

>SMED30000938-orf-1 ID=SMED30000938-orf-1|Name=SMED30000938-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=261bp
MTTQSSIDSKLEEQGLETILKSKATNYFYSGNYEELYKIIERNTFSEKSR
KQLQSFWLQAHYEEAEKARGKPLGPVEKYRIRKKYPMPISIWDGTNKSHC
FQEEIRKFLHHKYLKDPFPTSNMKKDMSSFTGLSVMQVSNWFKNRRQRDR
AAIGKNRKLSESNDSFQNAGKLSTKELPIQMHHVEAIKELAQIQSSNQTR
FKGFNIADLCVENETKNTDINMAKHPIIFNNLSNINAHMYFNYYFLNALR
ENNCIENLFL*
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Aliases
The feature 'Homeobox domain-containing protein' has the following synonyms
Synonym
six6*
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0009886post-embryonic animal morphogenesis
GO:0006355regulation of transcription, DNA-templated
GO:0000060protein import into nucleus, translocation
GO:0001654eye development
GO:0002070epithelial cell maturation
GO:0002088lens development in camera-type eye
GO:0003404optic vesicle morphogenesis
GO:0006351transcription, DNA-templated
GO:0006366transcription from RNA polymerase II promoter
GO:0006606protein import into nucleus
GO:0007275multicellular organism development
GO:0007420brain development
GO:0009946proximal/distal axis specification
GO:0014016neuroblast differentiation
GO:0021536diencephalon development
GO:0021537telencephalon development
GO:0021797forebrain anterior/posterior pattern specification
GO:0021798forebrain dorsal/ventral pattern formation
GO:0021846cell proliferation in forebrain
GO:0021978telencephalon regionalization
GO:0021983pituitary gland development
GO:0030178negative regulation of Wnt signaling pathway
GO:0042127regulation of cell proliferation
GO:0043010camera-type eye development
GO:0045665negative regulation of neuron differentiation
GO:0045892negative regulation of transcription, DNA-templated
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0048512circadian behavior
GO:0060235lens induction in camera-type eye
GO:0061074regulation of neural retina development
GO:0070306lens fiber cell differentiation
GO:0097402neuroblast migration
GO:1901987regulation of cell cycle phase transition
GO:1902692regulation of neuroblast proliferation
GO:1902742apoptotic process involved in development
GO:1990086lens fiber cell apoptotic process
GO:2000177regulation of neural precursor cell proliferation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000028Category 2 cell
PLANA:0000034epidermis
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000418head
PLANA:0000429neoblast
PLANA:0002032epidermal cell
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR001356Homeobox_dom
IPR031701SIX1_SD
IPR009057Homeobox-like_sf
IPR017970Homeobox_CS
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0043565sequence-specific DNA binding
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001222transcription corepressor binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003713transcription coactivator activity
GO:0005102signaling receptor binding
GO:0005515protein binding
GO:0042826histone deacetylase binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001356Homeobox domainSMARTSM00389HOX_1coord: 95..156
e-value: 4.7E-10
score: 49.4
IPR001356Homeobox domainPFAMPF00046Homeodomaincoord: 100..150
e-value: 1.7E-9
score: 37.4
IPR001356Homeobox domainPROSITEPS50071HOMEOBOX_2coord: 101..152
score: 11.953
IPR001356Homeobox domainCDDcd00086homeodomaincoord: 97..150
e-value: 7.74044E-10
score: 51.4753
IPR031701Homeobox protein SIX1, N-terminal SD domainPFAMPF16878SIX1_SDcoord: 13..88
e-value: 1.5E-28
score: 99.5
NoneNo IPR availableGENE3DG3DSA:1.10.10.60coord: 95..162
e-value: 7.0E-12
score: 46.7
NoneNo IPR availablePANTHERPTHR10390HOMEOBOX PROTEIN SIXcoord: 15..199
NoneNo IPR availablePANTHERPTHR10390:SF33PROTEIN OPTIXcoord: 15..199
IPR017970Homeobox, conserved sitePROSITEPS00027HOMEOBOX_1coord: 127..150
IPR009057Homeobox-like domain superfamilySUPERFAMILYSSF46689Homeodomain-likecoord: 93..152