Coiled-coil domain-containing protein 186

Overview
NameCoiled-coil domain-containing protein 186
Smed IDSMED30000896
Length (bp)2409
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Coiled-coil domain-containing protein 186 (SMED30000896) t-SNE clustered cells

Violin plots show distribution of expression levels for Coiled-coil domain-containing protein 186 (SMED30000896) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Coiled-coil domain-containing protein 186 (SMED30000896) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Coiled-coil domain-containing protein 186 (SMED30000896) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000896

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30000896SMESG000062953.1 dd_Smed_v4_14004_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30000896SMESG000062953.1 dd_Smed_v4_14004_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Human
Match: CCDC186 (coiled-coil domain containing 186 [Source:HGNC Symbol;Acc:HGNC:24349])

HSP 1 Score: 181.03 bits (458), Expect = 1.216e-46
Identity = 193/642 (30.06%), Postives = 345/642 (53.74%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISD-FSTYE-------RELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVE-NHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINF-WENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            L  E+  +++   K  E+ + +KE+MV+K+ + E+++LD  K+ + LE +LR++   L+  TN+ +++++E + R+   + T E       RE++ LK  +     K+K  + + + E++ +KETK K +E    +   KEE   +R NCQ+++K YQ SE++ SN L   LR  K EL+K M+EK + +E +H+KI  EL+  K T      EL+ L+ K+K LE +++  E+ + + K+ I         L +++   +  + ++ +  QE + L      L  +  D +  +   R++ESELL F + L++KNA+LQ+E   L    +K      ++  Q  E +K+ N   E++   E +   EE + L  ++     ++K  + ++ +  D++ + ++KH + IKDL +QL ++              ++ V   S     S+     +S+ +L  +    D S         P   G +    N   +   +L                  I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQE-KGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC-EQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK-----------LDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRS---------PENTGSSVAVDNFPQVDKAML------------------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 884
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Human
Match: CCDC186 (coiled-coil domain containing 186 [Source:HGNC Symbol;Acc:HGNC:24349])

HSP 1 Score: 181.03 bits (458), Expect = 1.216e-46
Identity = 193/642 (30.06%), Postives = 345/642 (53.74%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISD-FSTYE-------RELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVE-NHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINF-WENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            L  E+  +++   K  E+ + +KE+MV+K+ + E+++LD  K+ + LE +LR++   L+  TN+ +++++E + R+   + T E       RE++ LK  +     K+K  + + + E++ +KETK K +E    +   KEE   +R NCQ+++K YQ SE++ SN L   LR  K EL+K M+EK + +E +H+KI  EL+  K T      EL+ L+ K+K LE +++  E+ + + K+ I         L +++   +  + ++ +  QE + L      L  +  D +  +   R++ESELL F + L++KNA+LQ+E   L    +K      ++  Q  E +K+ N   E++   E +   EE + L  ++     ++K  + ++ +  D++ + ++KH + IKDL +QL ++              ++ V   S     S+     +S+ +L  +    D S         P   G +    N   +   +L                  I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQE-KGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC-EQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK-----------LDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRS---------PENTGSSVAVDNFPQVDKAML------------------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 884
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Human
Match: CCDC186 (coiled-coil domain containing 186 [Source:HGNC Symbol;Acc:HGNC:24349])

HSP 1 Score: 77.0258 bits (188), Expect = 3.751e-14
Identity = 110/414 (26.57%), Postives = 201/414 (48.55%), Query Frame = 2 
Query:  674 KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVE-NHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINF-WENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKS 1909
            KEE   +R NCQ+++K YQ SE++ SN L   LR  K EL+K M+EK + +E +H+KI  EL+  K T      EL+ L+ K+K LE +++  E+ + + K+ I         L +++   +  + ++ +  QE + L      L  +  D +  +   R++ESELL F + L++KNA+LQ+E   L    +K      ++  Q  E +K+ N   E++   E +   EE + L  ++     ++K  + ++ +  D++ + ++KH + IKDL +QL ++              ++ V   S     S+     +S+ +L  +    D S         P   G +    N   +   +L                  I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+
Sbjct:   53 KEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC-EQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK-----------LDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRS---------PENTGSSVAVDNFPQVDKAML------------------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKT 426
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Celegans
Match: cccp-1 (CCCP-1; Conserved Coiled-Coil Protein [Source:UniProtKB/TrEMBL;Acc:Q8I0Z1])

HSP 1 Score: 73.559 bits (179), Expect = 3.803e-13
Identity = 50/138 (36.23%), Postives = 82/138 (59.42%), Query Frame = 2 
Query: 1793 QVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSM----IARKGG---IMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSEN 2185
            Q+ IDKI+ LQ+  A+  EK EFL EH  Q  +++Q+K+ +I++ F+  EE     S L+    S+    I RK     +M ++F+S   +E   +++  E+N RLQ+VLED   KN  ++ S++TL  + ++LS EN
Sbjct:  589 QIMIDKIVILQRKLARRTEKCEFLEEHVRQCLEELQKKTKIIQH-FALREEA----SLLMPSEGSLEKVPIGRKSAAYALMGAMFTS-SGNEKKQVQIMTEVNSRLQAVLEDVIQKNILMRSSVDTLSADNTRLSREN 720
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Celegans
Match: cccp-1 (CCCP-1; Conserved Coiled-Coil Protein [Source:UniProtKB/TrEMBL;Acc:Q8I0Z1])

HSP 1 Score: 73.559 bits (179), Expect = 3.803e-13
Identity = 50/138 (36.23%), Postives = 82/138 (59.42%), Query Frame = 2 
Query: 1793 QVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSM----IARKGG---IMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSEN 2185
            Q+ IDKI+ LQ+  A+  EK EFL EH  Q  +++Q+K+ +I++ F+  EE     S L+    S+    I RK     +M ++F+S   +E   +++  E+N RLQ+VLED   KN  ++ S++TL  + ++LS EN
Sbjct:  589 QIMIDKIVILQRKLARRTEKCEFLEEHVRQCLEELQKKTKIIQH-FALREEA----SLLMPSEGSLEKVPIGRKSAAYALMGAMFTS-SGNEKKQVQIMTEVNSRLQAVLEDVIQKNILMRSSVDTLSADNTRLSREN 720
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Celegans
Match: cccp-1 (CCCP-1; Conserved Coiled-Coil Protein [Source:UniProtKB/TrEMBL;Acc:Q8I0Z1])

HSP 1 Score: 70.8626 bits (172), Expect = 2.739e-12
Identity = 49/143 (34.27%), Postives = 83/143 (58.04%), Query Frame = 2 
Query: 1793 QVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEE-------KGSVKSDLIDDNHSM--IARKGG---IMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSEN 2185
            Q+ IDKI+ LQ+  A+  EK EFL EH  Q  +++Q+K+ +I++ F+  EE       +GS++    +       I RK     +M ++F+S   +E   +++  E+N RLQ+VLED   KN  ++ S++TL  + ++LS EN
Sbjct:  589 QIMIDKIVILQRKLARRTEKCEFLEEHVRQCLEELQKKTKIIQH-FALREEASLLMPSEGSLEKLFANCEFVQVPIGRKSAAYALMGAMFTS-SGNEKKQVQIMTEVNSRLQAVLEDVIQKNILMRSSVDTLSADNTRLSREN 729
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Celegans
Match: cccp-1 (CCCP-1; Conserved Coiled-Coil Protein [Source:UniProtKB/TrEMBL;Acc:Q8I0Z1])

HSP 1 Score: 70.8626 bits (172), Expect = 2.739e-12
Identity = 49/143 (34.27%), Postives = 83/143 (58.04%), Query Frame = 2 
Query: 1793 QVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEE-------KGSVKSDLIDDNHSM--IARKGG---IMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSEN 2185
            Q+ IDKI+ LQ+  A+  EK EFL EH  Q  +++Q+K+ +I++ F+  EE       +GS++    +       I RK     +M ++F+S   +E   +++  E+N RLQ+VLED   KN  ++ S++TL  + ++LS EN
Sbjct:  589 QIMIDKIVILQRKLARRTEKCEFLEEHVRQCLEELQKKTKIIQH-FALREEASLLMPSEGSLEKLFANCEFVQVPIGRKSAAYALMGAMFTS-SGNEKKQVQIMTEVNSRLQAVLEDVIQKNILMRSSVDTLSADNTRLSREN 729
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Fly
Match: Golgin104 (gene:FBgn0036614 transcript:FBtr0075428)

HSP 1 Score: 111.309 bits (277), Expect = 8.889e-25
Identity = 108/368 (29.35%), Postives = 180/368 (48.91%), Query Frame = 2 
Query: 1103 LRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEK---SHTQILKVD-LQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKG-GIMASVF---SSRQADEN--MTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLS 2176
            L  + +DNE  L  L+ K  ELL   + +S    +LQ +   L++AK +   +  ++LK + L Y     K N  E +   E+    EER  L K +   T   + T  KL D      + Q KH   +K+L R+L K           K+ I  P   K+    CS   ++ N       +   +  S +            ++          + +       ++Q + P  +V +++I+RLQQ  A+  E+IEFL  HT  L  ++Q+KS ++++   + +  G++ +   D N S + + G GIMA+++   SS+   EN  M+LELSLEIN++LQ+VLEDT +KN TLK++++ LG E+  L+
Sbjct:  416 LEALVQDNETDLEQLKVKRQELLTINKEMSELIVQLQNDIC-LAKAKAQGLDAENKLLKQEKLTYD---TKYNQLEQQLSLEASEKNEERLLLAKHLSEKTKMYELTKQKLEDVQGDFEATQHKHATVLKELHRELNKY----------KRGITEP---KTPISYCSNCQQAINGYPTENPQQRSHSRSSSHGSMHSGSRRASESSESETVASSATTVQQPPPQQDLQAV-PSKKVLVERILRLQQATARQTERIEFLENHTAALVAEVQKKSKVVQHYMLRDQTAGALTTSRSDQNKSELVKYGNGIMAAIYGGGSSKTGGENKAMSLELSLEINKKLQAVLEDTLLKNITLKENLDVLGLEVDNLT 765
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Match: CR352283.2 (si:ch211-225b10.4 [Source:NCBI gene;Acc:557112])

HSP 1 Score: 125.946 bits (315), Expect = 3.030e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  721 VLVERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 845
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Match: ccdc186 (si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318-3])

HSP 1 Score: 125.946 bits (315), Expect = 3.599e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  774 VLVERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 898
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Match: CR352283.2 (si:ch211-225b10.4 [Source:NCBI gene;Acc:557112])

HSP 1 Score: 125.946 bits (315), Expect = 3.676e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  809 VLVERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 933
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Match: CR352283.2 (si:ch211-225b10.4 [Source:NCBI gene;Acc:557112])

HSP 1 Score: 125.946 bits (315), Expect = 3.845e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  817 VLVERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 941
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Match: ccdc186 (si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318-3])

HSP 1 Score: 125.946 bits (315), Expect = 3.878e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  817 VLVERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 941
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Xenopus
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:733717])

HSP 1 Score: 191.045 bits (484), Expect = 4.535e-50
Identity = 207/670 (30.90%), Postives = 335/670 (50.00%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRE-------SKFNLDLVTNEKEKITKELRSRISDFSTYER-------ELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVL---KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQE---------NDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQEL---------SEAKEKSHTQILK---VDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            L  E+  + +   K  E+ + +KESMV+K+ + E+++LD  K+ + LE +LRE       S   + L+T EK ++ +   S+ S+ S   R       E+NN    +  A  KLK E              K+  + LQ   + L   KEE   +R NCQE++K Y+ SE++ S+ L   L+  K EL+K M+EK + +E H     EL   K T      EL+ L+ K+K LEA+++  EE + + K+       I  Q  E I NL+     +DQ  ++          D L   N+ +  +  D EG     R +ESELL F + L++KNA LQ+E   L         SE++ +S  + L+    DL  +  +      + K     ++ LEE+++L+  ++   D+LK          +++ S ++KH  ++KDL +QL + N+           +  PV G                               +PI S F  F  G     S+ +   SP  S S        E    + I++IIRLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D+N + ++++GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  269 LHKEMAFRTEQANKKCEEARQEKESMVMKYVRGEKESLDLRKEKEALERKLREANKEIEKSSNRIKLLTQEKGRLHQLCESKESETSRQNRDIEKLKEEVNNYAIKVKWANNKLKTE----------LDSHKETKDRLQNTSIKLNQAKEEADQIRRNCQEMIKSYKESEEVKSSDLDARLKVTKVELEKQMQEKSDHLEVHQAKIKELDDLKRTFTEGMDELRTLRTKVKCLEAERLRTEEELSKYKE------LINRQKAE-IQNLQDKAKVLDQQEEQHQRQEMESLRDELSSLNSVISDLQSDIEGS----RTRESELLGFTEKLTSKNARLQSESNSLQAQLDKLTYSESELRSQLEQLRRENTDLNGR--LISEGAQQKKEVQALQTELEEQQKLVASLNTRVDELK----------NELASQKRKHAVNLKDLTKQLQQGNVCG--------SLSCPVKGS------------------------------HPI-SVF--FPTGSLNARSSNED-RSPENSGSSAAVDSFPEVDKAILIERIIRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQTYILR--EEAGTLSSEASDNNKAHLSKRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 861
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Xenopus
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:733717])

HSP 1 Score: 189.889 bits (481), Expect = 1.056e-49
Identity = 200/666 (30.03%), Postives = 332/666 (49.85%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRE-------SKFNLDLVTNEKEKITKELRSRISDFSTYER-------ELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVL---KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQE----NDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQEL---------SEAKEKSHTQILK---VDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNM-PDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            L  E+  + +   K  E+ + +KESMV+K+ + E+++LD  K+ + LE +LRE       S   + L+T EK ++ +   S+ S+ S   R       E+NN    +  A  KLK E              K+  + LQ   + L   KEE   +R NCQE++K Y+ SE++ S+ L   L+  K EL+K M+EK + +E H     EL   K T      EL+ L+ K+K LEA+++  EE + + K+ I         L ++   L+  E +  +  QE     D L   N+ +  +  D EG     R +ESELL F + L++KNA LQ+E   L         SE++ +S  + L+    DL  +  +      + K     ++ LEE+++L+  ++   D+LK          +++ S ++KH  ++KDL +QL + N+  D+  ++          G+S     S  D S                          P  +G +    +   +   IL                  I++IIRLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D+N + ++++GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  269 LHKEMAFRTEQANKKCEEARQEKESMVMKYVRGEKESLDLRKEKEALERKLREANKEIEKSSNRIKLLTQEKGRLHQLCESKESETSRQNRDIEKLKEEVNNYAIKVKWANNKLKTE----------LDSHKETKDRLQNTSIKLNQAKEEADQIRRNCQEMIKSYKESEEVKSSDLDARLKVTKVELEKQMQEKSDHLEVHQAKIKELDDLKRTFTEGMDELRTLRTKVKCLEAERLRTEEELSKYKELINRQKAEIQNLQDKAKVLDQQEEQHQRDRQEMESLRDELSSLNSVISDLQSDIEGS----RTRESELLGFTEKLTSKNARLQSESNSLQAQLDKLTYSESELRSQLEQLRRENTDLNGR--LISEGAQQKKEVQALQTELEEQQKLVASLNTRVDELK----------NELASQKRKHAVNLKDLTKQLQQGNVSADMGPLDR--------FGRSLNARSSNEDRS--------------------------PENSGSSAAVDSFPEVDKAIL------------------IERIIRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQTYILR--EEAGTLSSEASDNNKAHLSKRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 854
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Xenopus
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:733717])

HSP 1 Score: 184.496 bits (467), Expect = 7.261e-48
Identity = 199/668 (29.79%), Postives = 336/668 (50.30%), Query Frame = 2 
Query:  272 LTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRE-------SKFNLDLVTNEKEKITKELRSRISDFSTYER-------ELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVL---KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQE----NDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQEL---------SEAKEKSHTQILK---VDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            +  L  E+  + +   K  E+ + +KESMV+K+ + E+++LD  K+ + LE +LRE       S   + L+T EK ++ +   S+ S+ S   R       E+NN    +  A  KLK E              K+  + LQ   + L   KEE   +R NCQE++K Y+ SE++ S+ L   L+  K EL+K M+EK + +E H     EL   K T      EL+ L+ K+K LEA+++  EE + + K+ I         L ++   L+  E +  +  QE     D L   N+ +  +  D EG     R +ESELL F + L++KNA LQ+E   L         SE++ +S  + L+    DL  +  +      + K     ++ LEE+++L+  ++   D+LK          +++ S ++KH  ++KDL +Q           + + +  +  V   S +   S+     +S+ +L  +    D S         P  +G +    +   +   IL                  I++IIRLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D+N + ++++GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  266 IQQLHKEMAFRTEQANKKCEEARQEKESMVMKYVRGEKESLDLRKEKEALERKLREANKEIEKSSNRIKLLTQEKGRLHQLCESKESETSRQNRDIEKLKEEVNNYAIKVKWANNKLKTE----------LDSHKETKDRLQNTSIKLNQAKEEADQIRRNCQEMIKSYKESEEVKSSDLDARLKVTKVELEKQMQEKSDHLEVHQAKIKELDDLKRTFTEGMDELRTLRTKVKCLEAERLRTEEELSKYKELINRQKAEIQNLQDKAKVLDQQEEQHQRDRQEMESLRDELSSLNSVISDLQSDIEGS----RTRESELLGFTEKLTSKNARLQSESNSLQAQLDKLTYSESELRSQLEQLRRENTDLNGR--LISEGAQQKKEVQALQTELEEQQKLVASLNTRVDELK----------NELASQKRKHAVNLKDLTKQ-----------LQQARKKLEQVENGSYEKEVSSMGSRSSSSGSLNARSSNEDRS---------PENSGSSAAVDSFPEVDKAIL------------------IERIIRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQTYILR--EEAGTLSSEASDNNKAHLSKRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 867
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Xenopus
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:733717])

HSP 1 Score: 177.948 bits (450), Expect = 8.915e-46
Identity = 194/656 (29.57%), Postives = 324/656 (49.39%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRE-------SKFNLDLVTNEKEKITKELRSRISDFSTYER-------ELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVL---KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQE----NDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQEL---------SEAKEKSHTQILK---VDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNM-PDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSI 2143
            L  E+  + +   K  E+ + +KESMV+K+ + E+++LD  K+ + LE +LRE       S   + L+T EK ++ +   S+ S+ S   R       E+NN    +  A  KLK E              K+  + LQ   + L   KEE   +R NCQE++K Y+ SE++ S+ L   L+  K EL+K M+EK + +E H     EL   K T      EL+ L+ K+K LEA+++  EE + + K+ I         L ++   L+  E +  +  QE     D L   N+ +  +  D EG     R +ESELL F + L++KNA LQ+E   L         SE++ +S  + L+    DL  +  +      + K     ++ LEE+++L+  ++   D+LK          +++ S ++KH  ++KDL +QL + N+  D+  ++          G+S     S  D S                          P  +G +    +   +   IL                  I++IIRLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D+N + ++++GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK ++
Sbjct:  269 LHKEMAFRTEQANKKCEEARQEKESMVMKYVRGEKESLDLRKEKEALERKLREANKEIEKSSNRIKLLTQEKGRLHQLCESKESETSRQNRDIEKLKEEVNNYAIKVKWANNKLKTE----------LDSHKETKDRLQNTSIKLNQAKEEADQIRRNCQEMIKSYKESEEVKSSDLDARLKVTKVELEKQMQEKSDHLEVHQAKIKELDDLKRTFTEGMDELRTLRTKVKCLEAERLRTEEELSKYKELINRQKAEIQNLQDKAKVLDQQEEQHQRDRQEMESLRDELSSLNSVISDLQSDIEGS----RTRESELLGFTEKLTSKNARLQSESNSLQAQLDKLTYSESELRSQLEQLRRENTDLNGR--LISEGAQQKKEVQALQTELEEQQKLVASLNTRVDELK----------NELASQKRKHAVNLKDLTKQLQQGNVSADMGPLDR--------FGRSLNARSSNEDRS--------------------------PENSGSSAAVDSFPEVDKAIL------------------IERIIRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQTYILR--EEAGTLSSEASDNNKAHLSKRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKVTV 844
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Mouse
Match: Ccdc186 (coiled-coil domain containing 186 [Source:MGI Symbol;Acc:MGI:2445022])

HSP 1 Score: 123.25 bits (308), Expect = 1.352e-31
Identity = 62/127 (48.82%), Postives = 96/127 (75.59%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            + I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:   55 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 179
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Mouse
Match: Ccdc186 (coiled-coil domain containing 186 [Source:MGI Symbol;Acc:MGI:2445022])

HSP 1 Score: 124.79 bits (312), Expect = 1.036e-28
Identity = 62/127 (48.82%), Postives = 96/127 (75.59%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            + I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  779 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 903
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Mouse
Match: Ccdc186 (coiled-coil domain containing 186 [Source:MGI Symbol;Acc:MGI:2445022])

HSP 1 Score: 124.79 bits (312), Expect = 1.036e-28
Identity = 62/127 (48.82%), Postives = 96/127 (75.59%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            + I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  779 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 903
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. UniProt/SwissProt
Match: sp|Q7Z3E2|CC186_HUMAN (Coiled-coil domain-containing protein 186 OS=Homo sapiens OX=9606 GN=CCDC186 PE=1 SV=2)

HSP 1 Score: 181.03 bits (458), Expect = 5.840e-46
Identity = 193/642 (30.06%), Postives = 345/642 (53.74%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISD-FSTYE-------RELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVE-NHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINF-WENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            L  E+  +++   K  E+ + +KE+MV+K+ + E+++LD  K+ + LE +LR++   L+  TN+ +++++E + R+   + T E       RE++ LK  +     K+K  + + + E++ +KETK K +E    +   KEE   +R NCQ+++K YQ SE++ SN L   LR  K EL+K M+EK + +E +H+KI  EL+  K T      EL+ L+ K+K LE +++  E+ + + K+ I         L +++   +  + ++ +  QE + L      L  +  D +  +   R++ESELL F + L++KNA+LQ+E   L    +K      ++  Q  E +K+ N   E++   E +   EE + L  ++     ++K  + ++ +  D++ + ++KH + IKDL +QL ++              ++ V   S     S+     +S+ +L  +    D S         P   G +    N   +   +L                  I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQE-KGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC-EQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK-----------LDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRS---------PENTGSSVAVDNFPQVDKAML------------------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 884
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. UniProt/SwissProt
Match: sp|Q5R9B3|CC186_PONAB (Coiled-coil domain-containing protein 186 (Fragment) OS=Pongo abelii OX=9601 GN=CCDC186 PE=2 SV=2)

HSP 1 Score: 177.948 bits (450), Expect = 1.280e-45
Identity = 192/645 (29.77%), Postives = 347/645 (53.80%), Query Frame = 2 
Query:  272 LTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISD-FSTYE-------RELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVE-NHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINF-WENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            +  L  E+  +++   K  E+ + +KE+MV+K+ + E+++LD  K+ + LE +LR++   L+  TN+ +++++E + R+   + T E       RE++ LK  +     ++K  + + + E++ +KETK K +E    +   KEE   +R NCQ+++K YQ SE++ SN L   LR  K EL+K M+EK + +E +H+KI  EL+  K T      EL+ L+ K+K LE +++  E+ + + K+ I         L +++  ++  + ++ +  QE + L      L  +  D +  +   R++ESELL F + L++KNA+LQ+E   L    +K      ++  Q  E +K+ N   E++   E +   EE + L  ++     ++K  + ++ +  D++ + ++KH + IKDL +QL ++              ++ V   S     S+     +S+ +L  +    D S         P   G +    N   +   +L                  I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:   74 IQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQE-KGRLHQLYETKEGETTRLIREIDKLKEDINSHVIEVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKIVDQLQEQLQRGKQEIENLKEEVESLNSLISDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKLSCSESQLQSQC-EQMKQTNINLESRLLKEEELRKEEVQTLQAELTCRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK-----------LDQVENGSYDKEVSSMGSRSSSSGSLNARSSAEDRS---------PENTGSSVAVDNFPQVDKAML------------------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 675
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. UniProt/SwissProt
Match: sp|Q8C9S4|CC186_MOUSE (Coiled-coil domain-containing protein 186 OS=Mus musculus OX=10090 GN=Ccdc186 PE=1 SV=2)

HSP 1 Score: 124.79 bits (312), Expect = 7.246e-28
Identity = 62/127 (48.82%), Postives = 96/127 (75.59%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            + I++I+RLQ+ +A+  EKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N   ++R+GGIMAS+++S  AD  +TLELSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  779 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLR--EESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL 903
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Match: A0A2T7P993 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_09258 PE=4 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 2.017e-58
Identity = 206/671 (30.70%), Postives = 354/671 (52.76%), Query Frame = 2 
Query:  272 LTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRE---------SKFNLDLVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQ-------ENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQ-------ELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKS---LLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLKNNL 2206
            +  L++E++ ++D +TK+YED   +K+SMV++FA+AE KN+++ +    LE ++RE         SK        EK+K   EL  ++ +     +E+  +K  L+ A+ ++K  + + + E+E +KETK   E+    +   KEE   +R +CQ I+K YQ SE++ SNSL   L+  + EL   M++K +  E   K   EL+  K       +ELK LK+K++ LE +++  E+   + +  I++       L +++          D+  +       E   L ++N +L+K   D EG     + +ES++L     LS  NA L++E          LS   +K   +I  ++ + ++A++ +   + K K E+ S       L  Q+   T + +    K  D  D   +L++KH  +IKDL RQL        +   ++ +     SG+   +S  +     NSN +L   D+   ++           TN    ++  C   +  +L    P+  + +E   Q+ I++I+RLQ+  A+  EK+EFL EH  QL  +I+RK+   ++  Y+    EE G++ S+ +D N +++ARKGGIMAS++S  Q D  MTL+LSLEIN++LQ+VLEDT +KN TLK++++TLG EI++LS EN RL+ +L
Sbjct:  569 IATLQTEMKGRIDQITKLYEDATREKDSMVIRFAEAETKNMESKRAADRLEAKIRELLKEKESLNSKIKAAFT--EKQKALAELEIKVGERIAIGKEMEKMKEELSSADYRIKWFQNKLKAELEAHKETKTNLEKTAAKLKEAKEETEQIRQDCQAIIKTYQESEEVRSNSLDKELKMKEMELMIQMKQKTDTEEIQQKTKRELETMKMQYKDALEELKTLKDKVQCLEEERLQGEQLQSKYQTIIQNQKGDNADLQKKVTGFLTLHEDFDRAQEMIRTLDHEIGELKISNRDLQK---DLEGC----QARESKMLALQSELSRTNALLRSENTIFNNQIVTLSGDVQKMKMEIQDLETRCRDAIENLEEEKKKRKEETTS-------LAAQLAEKTKECEEYKQKWEDEIDSNKTLKRKHMNNIKDLTRQL--------HSARKRLEAYETGSGERDNLSMGSR---TNSNGSLNSTDNSTHFA-----------TNQSNHHHGACTTTSQDLLHLEYPVITEQVEVDRQLLIERIVRLQKSLARKNEKLEFLEEHIQQLVAEIKRKNKQVIIQGYVLR--EEAGTLASEDMDANKALLARKGGIMASLYSMHQQDGTMTLDLSLEINKKLQAVLEDTLLKNMTLKENLDTLGTEIARLSQENRRLQLHL 1199
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Match: A0A1S3JVD6 (coiled-coil domain-containing protein 186 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106176497 PE=4 SV=1)

HSP 1 Score: 221.476 bits (563), Expect = 8.739e-57
Identity = 199/652 (30.52%), Postives = 364/652 (55.83%), Query Frame = 2 
Query:  281 LKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVT-------NEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVL---KEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREEL---LKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLK 2197
            LK ++  K++   K  E+   +K++MV+K+AQ+E K L+  + +++LE + ++     D VT        +  K+T+ L +R  +    ++EL  LK +++  + K+K  + + + E++ +KETK +   LQ+ +  L   +EEN  +R + QE++K YQ SE++ SNSL   L++ + ELK+  +EK +  E  S +  EL   K        EL   ++K+K LE +++ QE ++ +LK+ I++       L +++  L+   ++++   ++ ++L  +  E+ + + D E  +   R++E+ELLEF + +S KNA+LQ+E   L      S  ++ K++   KE  K       + + E K+  EE  E    L++ + L D L     +L+D+ DQ  +L+KKH  ++KDL+RQL  +     N  +E ++  + ++  S   S S+ ++  N +   +                 T  + G ++      P   P          ++IEP  Q+ I++I++LQ+ +A+  EK+EF+ +H  QL  ++Q+K+ +I+ ++   EE G++    +D+N + +ARKGGIMASV+    AD +MT+ELSLEI ++LQ+VLEDT +KN TLK++++TLG EI++LS EN +L+
Sbjct:  339 LKQDMMWKLEQAGKKCEETIKEKDAMVMKYAQSEAKLLELSQAIEKLENKNKDVAKEKDNVTAKFKAMKTDNTKLTQCLEARGREVRGLQKELEKLKEAISSNDVKVKWAQNKLKAELDAHKETKAE---LQKTIQKLNETREENEQIRRDGQEMIKTYQESEEVRSNSLDIELKRKESELKQHKQEKNDQEEVFSIMCRELDSLKKQHKDALAELGTFRDKVKCLETERLSQEASMLKLKEIIQNQKRDIQDLRQQVDELQNARTQLEVEREKVEKLTSSLEEVNQCNRDLEADMDGCRKREAELLEFTEKISAKNAQLQSENNGLHSKVTVSSAELEKLNSLCKELQKTTQQLTEELECEKKARSEETTEFTDKLREKNTLVDQL---TVQLNDAVDQQKTLKKKHAGNVKDLLRQLHHAKKRLENYESEAEEKNHKMNHGSRASSTSSLEKVNNGHAGGS-----------------TATSRGSSQEPQTQDPHAIPA--------TEVIEPDRQMLIERIVKLQKAHARKNEKMEFMQDHIKQLIDEVQKKARIIQ-MYVMREEAGALAPLSMDENKAQLARKGGIMASVYKMHAADGHMTIELSLEIMKKLQAVLEDTILKNITLKENLDTLGAEIARLSQENRQLQ 958
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Match: A0A267E1P3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig016060g3 PE=4 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 1.942e-53
Identity = 191/673 (28.38%), Postives = 339/673 (50.37%), Query Frame = 2 
Query:  287 SELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLD-------LVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTE------KQELSEAKEKSHTQ----ILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSC--------------------SASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRL 2194
            S +R  VD L +  ++   ++E++V+KFA AEQ+ L+  K  K+ +   RE++   D       L+  EK+++  +   +    +  E+EL +L+ +   A+ ++K  + +  EE E ++E+ K+ EE QR +  L ++   LR          Q+S+                           AV+   ++       +  +     EL+  +E++K  EA+++CQEE   + ++++   T    +L +R+ +L   E ++ Q  +  D L     E   + +D +  L  LR KESELLEF Q +S+KNA LQ E      +Q    A+ +S  Q    + + + + +E V+ +       ++E    L+ER   L Q   + +DL     +L D  ++  + ++KH A +KDL+RQL  +      K  + +D +  VS  S+  S                      AS +S  +NQ + +    +        +     +NG +    +     S I       +++++EP  Q  I+KI+RLQ+  ++  EKI+FL EH  QLT+++Q+K  L+++   + EE GS+  +  D N + ++RKGGIMAS+ +++ +D+ +TLE SLEIN+++QSVLED  +KN TLK++I+TLG+EI++LS+EN RL
Sbjct:   67 SGVRASVDKLRRQADEAAREREALVVKFASAEQRILEAQKAAKQADATAREAQKERDAAVARQKLLAGEKDRLASQAEQKCVQVANLEKELLSLREASGSADVRVKWAQNKLREEQEAHRESAKRLEEAQRQIRQLAQDRDQLRQG--------QDSQ-------------------------TAAVKEAEQL-------RRQLAEAGAELRQARERLKLAEAERICQEEAASRGRESLAKATEECVRLKQRLRHLSELEEQLGQARRLADDLKRQLDEANGVCKDQQAELELLRSKESELLEFTQKMSDKNAGLQAENLTLLNQQSADRARWESLEQEARSLREANARLQEQVESLTG----QQSEELHSLQER---LAQRAKIAEDLA---VQLEDERNEAKTQRRKHTALVKDLMRQLASAK-----KKLDSRDGIKEVSRASSNSSLEVTTGAGAAAPASAVGEAGQPASAQSQEANQPVAKAYATSGVCTGAGANSAPRASNGPSPAADD----ASSIGDLGPSFDIKVVEPDRQALIEKIVRLQRDRSRRTEKIDFLNEHVRQLTEELQKKHRLLQHYILR-EESGSIAPEAFDVNKANLSRKGGIMASLHTTQISDKALTLEFSLEINKKMQSVLEDALLKNITLKENISTLGDEIARLSTENYRL 679
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Match: A0A267EHF6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006919g1 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 2.313e-53
Identity = 191/673 (28.38%), Postives = 339/673 (50.37%), Query Frame = 2 
Query:  287 SELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLD-------LVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTE------KQELSEAKEKSHTQ----ILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSC--------------------SASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRL 2194
            S +R  VD L +  ++   ++E++V+KFA AEQ+ L+  K  K+ +   RE++   D       L+  EK+++  +   +    +  E+EL +L+ +   A+ ++K  + +  EE E ++E+ K+ EE QR +  L ++   LR          Q+S+                           AV+   ++       +  +     EL+  +E++K  EA+++CQEE   + ++++   T    +L +R+ +L   E ++ Q  +  D L     E   + +D +  L  LR KESELLEF Q +S+KNA LQ E      +Q    A+ +S  Q    + + + + +E V+ +       ++E    L+ER   L Q   + +DL     +L D  ++  + ++KH A +KDL+RQL  +      K  + +D +  VS  S+  S                      AS +S  +NQ + +    +        +     +NG +    +     S I       +++++EP  Q  I+KI+RLQ+  ++  EKI+FL EH  QLT+++Q+K  L+++   + EE GS+  +  D N + ++RKGGIMAS+ +++ +D+ +TLE SLEIN+++QSVLED  +KN TLK++I+TLG+EI++LS+EN RL
Sbjct:   67 SGVRASVDKLRRQADEAAREREALVVKFASAEQRILEAQKAAKQADATAREAQKERDAAVARQKLLAGEKDRLASQAEQKCVQVANLEKELLSLREASGSADVRVKWAQNKLREEQEAHRESAKRLEEAQRQIRQLAQDRDQLRQG--------QDSQ-------------------------TAAVKEAEQL-------RRQLAEAGAELRQARERLKLAEAERICQEEAASRGRESLAKATEECVRLKQRLRHLSELEEQLGQARRLADDLKRQLDEANGVCKDQQAELELLRSKESELLEFTQKMSDKNAGLQAENLTLLNQQSADRARWESLEQEARSLREANARLQEQVESLTG----QQSEELHSLQER---LAQRAKIAEDLA---VQLEDERNEAKTQRRKHTALVKDLMRQLASAK-----KKLDSRDGIKEVSRASSNSSLEVTTGAGAAAPASAVGEAGQPASAQSQEANQPVAKAYATSGVCTGAGANSAPRASNGPSPAADDA----SSIGDLGPSFDIKVVEPDRQALIEKIVRLQRDRSRRTEKIDFLNEHVRQLTEELQKKHRLLQHYILR-EESGSIAPEAFDVNKANLSRKGGIMASLHTTQISDKALTLEFSLEINKKMQSVLEDALLKNITLKENISTLGDEIARLSTENYRL 679
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Match: A0A267EC88 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006919g2 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 2.451e-53
Identity = 189/673 (28.08%), Postives = 338/673 (50.22%), Query Frame = 2 
Query:  287 SELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLD-------LVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTE------KQELSEAKEKSHTQ----ILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSC--------------------SASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRL 2194
            S +R  VD L +  ++   ++E++V+KFA AEQ+ L+  K  K+ +   RE++   D       L+  EK+++  +   +    +  E+EL +L+ +   A+ ++K  + +  EE E ++E+ K+ EE QR +  L ++   LR          Q+S+                           AV+   ++       +  +     EL+  +E++K  EA+++CQEE   + ++++   T    +L +R+ +L   E ++ Q  +  D L     E   + +D +  L  LR KESELLEF Q +S+KNA LQ E      +Q    A+ +S  Q    + + + + +E V+ +   +++        L   +E L Q   + +DL     +L D  ++  + ++KH A +KDL+RQL  +      K  + +D +  VS  S+  S                      AS +S  +NQ + +    +        +     +NG +    +     S I       +++++EP  Q  I+KI+RLQ+  ++  EKI+FL EH  QLT+++Q+K  L+++   + EE GS+  +  D N + ++RKGGIMAS+ +++ +D+ +TLE SLEIN+++QSVLED  +KN TLK++I+TLG+EI++LS+EN RL
Sbjct:   67 SGVRASVDKLRRQADEAAREREALVVKFASAEQRILEAQKAAKQADATAREAQKERDAAVARQKLLAGEKDRLASQAEQKCVQVANLEKELLSLREASGSADVRVKWAQNKLREEQEAHRESAKRLEEAQRQIRQLAQDRDQLRQG--------QDSQ-------------------------TAAVKEAEQL-------RRQLAEAGAELRQARERLKLAEAERICQEEAASRGRESLAKATEECVRLKQRLRHLSELEEQLGQARRLADDLKRQLDEANGVCKDQQAELELLRSKESELLEFTQKMSDKNAGLQAENLTLLNQQSADRARWESLEQEARSLREANARLQEQVESLTGQQSEE-------LHSLQERLAQRAKIAEDLA---VQLEDERNEAKTQRRKHTALVKDLMRQLASAK-----KKLDSRDGIKEVSRASSNSSLEVTTGAGAAAPASAVGEAGQPASAQSQEANQPVAKAYATSGVCTGAGANSAPRASNGPSPAADDA----SSIGDLGPSFDIKVVEPDRQALIEKIVRLQRDRSRRTEKIDFLNEHVRQLTEELQKKHRLLQHYILR-EESGSIAPEAFDVNKANLSRKGGIMASLHTTQISDKALTLEFSLEINKKMQSVLEDALLKNITLKENISTLGDEIARLSTENYRL 679
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Cavefish
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:103044203])

HSP 1 Score: 125.176 bits (313), Expect = 5.696e-29
Identity = 61/127 (48.03%), Postives = 97/127 (76.38%), Query Frame = 2 
Query: 1796 VFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKL 2173
            V +++I+RLQ+ +A+  EKIEFL +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++++GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L
Sbjct:  849 VLVERIVRLQKAHARKNEKIEFLEDHIKQLVEEIRKKTKIIQSYVLR--EESGALSSEASDFNKAHLSKRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGSEIERL 973

HSP 2 Score: 93.9745 bits (232), Expect = 3.428e-19
Identity = 117/449 (26.06%), Postives = 235/449 (52.34%), Query Frame = 2 
Query:  197 LEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLD-------LVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAI-KSLTFIKDQLTERIANLEPFESRVDQVTQE----NDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKS 1507
            +E+LLK   + K K+  + +  +G +  ++ E+  +++  +K  E+ + +KESMV+K+ + E++ LD  K  ++LE +LRE+   +D        +  EK ++ +   ++ ++ +   REL  +K  +     K+K  + + + E + +KETK K +E    +   KEE   +R NCQ++++ YQ SE++ SN L   LR+ K EL+K  +E+ + +E H     EL   K T      EL  L+ K+K LE ++   E+ + + ++ I +  + I++Q  E++  ++  E + ++  QE     D +   N++   + +D +G     R +E+ELL F + L++KNA+LQ+E   L    ++       +  + +E  + +     + K E +    E + L  +   L  +  +   ++ +  D++ + ++K  A+IKDL +QLT++
Sbjct:  344 VEELLKELKESKDKLVHQDQAAKGAVQQMQREMAYRLEQASKKCEEARQEKESMVMKYVRGEKEALDLRKDKEQLERKLREATAEVDKQARRGNQLAQEKGRLQQLHEAKENEMARLSRELEKVKEEINSHVIKVKWAQNKLKSETDAHKETKDKLKETTAKLTQAKEETEQIRKNCQDMIRTYQESEEIKSNELDAKLRETKGELEKHKQEQTDQLEMHQAKIKELDDLKRTFKEGMDELTTLRTKVKCLEDERPRWEDELCKYREIINRQKSEIQNQ-REKLGAIQRLEEQHERDEQEIAALKDEVESLNSQTADLQKDVQGG----RVREAELLGFTERLTSKNAQLQSESNGLQAQLDRLAASSRDLQSRLEETERSLADMTARLKKEEQQRQSEVQTLQAERTALQSETAQLKTRVEELRDELVTQKRKQAANIKDLTKQLTQA 787
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Sea Lamprey
Match: ccdc186 (si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318-3])

HSP 1 Score: 186.422 bits (472), Expect = 1.325e-49
Identity = 196/654 (29.97%), Postives = 339/654 (51.83%), Query Frame = 2 
Query:  272 LTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRES-----KFN--LDLVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELS------EAKEKSHTQILKVDLQYKEAV-KKINFWENKSKAESKSWLEEREELLKQIDYL---TDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQL--TKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLS 2176
            +  ++ +L ++++   K  E+++ +KE+MV+K+ + E++ LD  K  + LE +LRES     KF   + L+T EK ++     +R  D     +E+   K  +     K+K  + + + E++ +KETK+K  E    +   +EE   +R NCQE++K YQ SE++ SN L   LR  + EL+K  EE+ + +E H     EL+  K        EL+ L+ K+K LE +++  EE + + ++ I        +L E +   +  + +++   QE   L      L  +  D    ++  R++E+ELL F + L++KNA+LQ++   L       EA E+   Q L+   Q KEA+  ++   + + + E +    E  E  +Q+  L    D+L+          D++ + ++KH A+ KD+ +QL   +  +  +    E ++     S  S+  S +    +G S                            + E +S     +SP  + S P      E    V I++I+RLQ+  AK  EK+EFL +H  QL ++++RK+ +I + +   EE G++ S+  D + + ++RKGGIMASVFSS+ AD  MTLELSL+IN +LQ+VLEDT +KN TLK+++ TLG+EI +L+
Sbjct:  179 MAQIQKDLTLRLEQANKRCEEDRKEKEAMVMKYVRGEKEALDLRKDKEGLEKKLRESMKEMEKFTARVKLLTQEKGRLGTLYEARDGDVHKLNKEIEKQKEEINSRASKIKWAQNKLKSELDSHKETKEKLRETTAKLSEAREETEQIRMNCQEMIKTYQESEEIKSNELDVRLRVTEGELRKRREEQNDYMEIHGAKIKELEHLKRNFKEGMDELRTLRTKVKCLEEERIRTEEELAKYREIINRQKAEIQELQEGVRAADRLQEQIESDEQEQAVLREELAGLNCLVADLRVDIAGSREREAELLAFAERLASKNAQLQSDSNGLQASVDRLEACERKLMQELQTQGQAKEALAAELGVVKKQLEEEQRRLGAELTEATRQLALLRTQADELR----------DELATQKRKHAANTKDMSKQLMHARRKLEQLETTQEGRESGGMGSRSSSSGSLNVR--AGGS----------------------------RDEGFSEVAG-SSPGTADSFP------EVDKSVLIERIVRLQKTLAKKNEKVEFLEDHNQQLLEELRRKTKII-HSYIMREESGALSSEASDMSKAQLSRKGGIMASVFSSQLADSTMTLELSLQINHKLQAVLEDTVLKNITLKENMQTLGKEIERLT 784
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Nematostella
Match: EDO42698 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0M4])

HSP 1 Score: 138.272 bits (347), Expect = 6.064e-37
Identity = 75/161 (46.58%), Postives = 112/161 (69.57%), Query Frame = 2 
Query: 1715 SNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLK 2197
            SNC   +SP    +  L  ++ E   ++ +DKI RLQ+ +AK  EK+EF+ EH   L  +IQ+K+ +I+Y ++  EE G +     D N + ++R GGIMAS++SS+  D NMTLELSLEIN++LQ+VLEDT +KN TLK++++TLG+EI++L+ E L LK
Sbjct:   72 SNC---SSPTTLQNTALTAKL-EIDKKILVDKICRLQRIHAKKNEKLEFMEEHISTLVDEIQKKTRIIQY-YALREEAGMLAPPKSDVNKAQLSRHGGIMASLYSSKPIDHNMTLELSLEINKKLQAVLEDTILKNMTLKENLDTLGDEITRLNDELLSLK 227
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Medaka
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:101162401])

HSP 1 Score: 198.749 bits (504), Expect = 1.489e-52
Identity = 190/672 (28.27%), Postives = 351/672 (52.23%), Query Frame = 2 
Query:  197 LEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDL-------VTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAI---KSLTFIKDQLTERIANLEPFESR-VDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIR-YLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLS 2176
            LE+LLK   D +  +    +  + +L  ++ E+  +++ + +  ++ + +KE+MV+K+ + E++ LD  +  + LE RLRE+   +D        +  EK ++ +   S+  +     RE+  LK  +     K+K  + + + E + +KETK K  E    +   KEE   +R NCQ++++ YQ SE++ SN L   LR+ K +L+K ++E+ + +E       EL+  K +      EL+ L+ K+K LE ++   E+ +   ++ I   K+    + +  E +  LE    R  D++    + +     ++  +  D +G     R++E+ELL F + LS+KNA+LQ+E   L    ++  +   +V  + +E  + ++    + K E     +E + L ++   L  ++ +   K+ +  D++ + ++K  A+IKDL +QL          I  +K + +  +G      C       + + N       +  SLN          +G T    +     SP+++ S P      E    V +D+I+RLQ+  A+ QEKIEF+ +H  QL ++I++K+ +I+ Y+    EE G++ S+  D N + ++R+GGIMAS+++S  AD  +TL+LSLEINR+LQ+VLEDT +KN TLK+++ TLG EI +L+
Sbjct:  349 LEELLKELKDSRDTLIHHEQTAKANLQQMQREMTCRIEQVNRKCDEARQEKEAMVMKYVRGEKEALDLRRDKESLEKRLREAVKEMDRQALRGNQLAQEKGRLQQLFDSKEGEVGRLTREVEKLKDEINSHLIKVKWAQNKLKSEADAHKETKDKLRETTSKLAQAKEETEQIRKNCQDMIRTYQESEELRSNELDAKLRETKGKLEKHIQEQTDQLEVQRLKEKELEDLKKSYKESMDELETLRTKLKCLEDERPRWEDELTNYREIINRQKAEIGRQREKVEEVTALEEQHQRDTDEIASLREEVSSLTAQMADLQRDVQGS----REREAELLGFTEKLSSKNAQLQSESNALQSQLDQLSSNFTEVQARLEETSRLLDDKSRQLKREEALRQQEVQGLQEERGALQTEVNQLKTKVEELRDELVTQKRKQAANIKDLTKQL----------IQARKKLEHVDNG-----GC-------DRDANSMGSRSSSSGSLN--------ARHGGTSGADDSSSAPSPVVADSFP------EVDKTVLVDRIVRLQKALARKQEKIEFMEDHIRQLVEEIRKKTKIIQSYVLR--EESGALSSEASDINKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLT 978
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Medaka
Match: ccdc186 (coiled-coil domain containing 186 [Source:NCBI gene;Acc:101162401])

HSP 1 Score: 115.546 bits (288), Expect = 5.121e-26
Identity = 148/598 (24.75%), Postives = 287/598 (47.99%), Query Frame = 2 
Query:  197 LEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDL-------VTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAI---KSLTFIKDQLTERIANLEPFESR-VDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSV 1957
            LE+LLK   D +  +    +  + +L  ++ E+  +++ + +  ++ + +KE+MV+K+ + E++ LD  +  + LE RLRE+   +D        +  EK ++ +   S+  +     RE+  LK  +     K+K  + + + E + +KETK K  E    +   KEE   +R NCQ++++ YQ SE++ SN L   LR+ K +L+K ++E+ + +E       EL+  K +      EL+ L+ K+K LE ++   E+ +   ++ I   K+    + +  E +  LE    R  D++    + +     ++  +  D +G     R++E+ELL F + LS+KNA+LQ+E   L    ++  +   +V  + +E  + ++    + K E     +E + L ++   L  ++ +   K+ +  D++ + ++K  A+IKDL +QL          I  +K + +  +G      C       + + N       +  SLN          +G T    +     SP+++ S P      E    V +D+I+RLQ+  A+ QEKIEF+ +H  QL ++I++K+  +    S   E G  
Sbjct:  349 LEELLKELKDSRDTLIHHEQTAKANLQQMQREMTCRIEQVNRKCDEARQEKEAMVMKYVRGEKEALDLRRDKESLEKRLREAVKEMDRQALRGNQLAQEKGRLQQLFDSKEGEVGRLTREVEKLKDEINSHLIKVKWAQNKLKSEADAHKETKDKLRETTSKLAQAKEETEQIRKNCQDMIRTYQESEELRSNELDAKLRETKGKLEKHIQEQTDQLEVQRLKEKELEDLKKSYKESMDELETLRTKLKCLEDERPRWEDELTNYREIINRQKAEIGRQREKVEEVTALEEQHQRDTDEIASLREEVSSLTAQMADLQRDVQGS----REREAELLGFTEKLSSKNAQLQSESNALQSQLDQLSSNFTEVQARLEETSRLLDDKSRQLKREEALRQQEVQGLQEERGALQTEVNQLKTKVEELRDELVTQKRKQAANIKDLTKQL----------IQARKKLEHVDNG-----GC-------DRDANSMGSRSSSSGSLN--------ARHGGTSGADDSSSAPSPVVADSFP------EVDKTVLVDRIVRLQKALARKQEKIEFMEDHIRQLVEEIRKKTNQVLAPHSSAPEGGGT 906
[Close]
BLAST of Coiled-coil domain-containing protein 186 vs. Planmine SMEST
Match: SMESG000062953.1 (SMESG000062953.1)

HSP 1 Score: 1366.29 bits (3535), Expect = 0.000e+0
Identity = 719/720 (99.86%), Postives = 720/720 (100.00%), Query Frame = 2 
Query:   56 MAEVDIACESSITDLEGQENKLESFNSKNEPENNNHTIEILTRTNKSLEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFXXXXXXXXXXXXXXXXLQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMXXXXXXXXXXXXXAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLKNNLNVS 2215
            MAEVDIACESSITDLEGQENKLESFNSKNEPENNNHTIEILTRTNKSLEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFEEEIEKNKETKKKYEELQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMKEELKKCMEEKKEAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTD+LKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLKNNLNVS
Sbjct:    1 MAEVDIACESSITDLEGQENKLESFNSKNEPENNNHTIEILTRTNKSLEDLLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKESMVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSRISDFSTYERELNNLKASLTIAEQKLKMEKVRFEEEIEKNKETKKKYEELQRNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMKEELKKCMEEKKEAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEETVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTELRKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSHTQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDNLKRTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVNPVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKTEYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKIEFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKGGIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLGEEISKLSSENLRLKNNLNVS 720
The following BLAST results are available for this feature:
BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CCDC1861.216e-4630.06coiled-coil domain containing 186 [Source:HGNC Sym... [more]
CCDC1861.216e-4630.06coiled-coil domain containing 186 [Source:HGNC Sym... [more]
CCDC1863.751e-1426.57coiled-coil domain containing 186 [Source:HGNC Sym... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cccp-13.803e-1336.23CCCP-1; Conserved Coiled-Coil Protein [Source:Uni... [more]
cccp-13.803e-1336.23CCCP-1; Conserved Coiled-Coil Protein [Source:Uni... [more]
cccp-12.739e-1234.27CCCP-1; Conserved Coiled-Coil Protein [Source:Uni... [more]
cccp-12.739e-1234.27CCCP-1; Conserved Coiled-Coil Protein [Source:Uni... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Golgin1048.889e-2529.35gene:FBgn0036614 transcript:FBtr0075428[more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CR352283.23.030e-2948.03si:ch211-225b10.4 [Source:NCBI gene;Acc:557112][more]
ccdc1863.599e-2948.03si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318... [more]
CR352283.23.676e-2948.03si:ch211-225b10.4 [Source:NCBI gene;Acc:557112][more]
CR352283.23.845e-2948.03si:ch211-225b10.4 [Source:NCBI gene;Acc:557112][more]
ccdc1863.878e-2948.03si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ccdc1864.535e-5030.90coiled-coil domain containing 186 [Source:NCBI gen... [more]
ccdc1861.056e-4930.03coiled-coil domain containing 186 [Source:NCBI gen... [more]
ccdc1867.261e-4829.79coiled-coil domain containing 186 [Source:NCBI gen... [more]
ccdc1868.915e-4629.57coiled-coil domain containing 186 [Source:NCBI gen... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Ccdc1861.352e-3148.82coiled-coil domain containing 186 [Source:MGI Symb... [more]
Ccdc1861.036e-2848.82coiled-coil domain containing 186 [Source:MGI Symb... [more]
Ccdc1861.036e-2848.82coiled-coil domain containing 186 [Source:MGI Symb... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q7Z3E2|CC186_HUMAN5.840e-4630.06Coiled-coil domain-containing protein 186 OS=Homo ... [more]
sp|Q5R9B3|CC186_PONAB1.280e-4529.77Coiled-coil domain-containing protein 186 (Fragmen... [more]
sp|Q8C9S4|CC186_MOUSE7.246e-2848.82Coiled-coil domain-containing protein 186 OS=Mus m... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2T7P9932.017e-5830.70Uncharacterized protein OS=Pomacea canaliculata OX... [more]
A0A1S3JVD68.739e-5730.52coiled-coil domain-containing protein 186 isoform ... [more]
A0A267E1P31.942e-5328.38Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267EHF62.313e-5328.38Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267EC882.451e-5328.08Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccdc1865.696e-2948.03coiled-coil domain containing 186 [Source:NCBI gen... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccdc1861.325e-4929.97si:ch211-225b10.4 [Source:ZFIN;Acc:ZDB-GENE-100318... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO426986.064e-3746.58Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ccdc1861.489e-5228.27coiled-coil domain containing 186 [Source:NCBI gen... [more]
ccdc1865.121e-2624.75coiled-coil domain containing 186 [Source:NCBI gen... [more]
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BLAST of Coiled-coil domain-containing protein 186 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000062953.10.000e+099.86SMESG000062953.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000896 ID=SMED30000896|Name=Coiled-coil domain-containing protein 186|organism=Schmidtea mediterranea sexual|type=transcript|length=2409bp
TTTAAAAGAATAATTTTTAAAATTTTAATAACTTGATTTTAAGAAGTCCT
TTTAAATGGCTGAAGTAGACATTGCATGTGAAAGTTCAATTACAGATTTG
GAAGGGCAGGAAAACAAATTAGAGTCATTTAACTCTAAAAATGAACCTGA
AAATAATAATCACACCATTGAAATTCTTACAAGGACGAACAAATCCCTTG
AAGATTTGTTAAAAGTACACAATGATGATAAAATTAAAATGAAAGAAGAA
ATTGAAAATTTACAAGGTCATCTAACAAATTTAAAATCAGAATTACGAAT
AAAAGTCGATCATTTAACTAAAATTTATGAAGACGAAAAACATGATAAGG
AATCTATGGTCTTAAAGTTTGCTCAAGCTGAACAAAAAAATTTGGATACA
TTGAAAAAAGTCAAAGAATTAGAAGGTCGCTTACGAGAATCCAAGTTTAA
TTTAGATCTAGTGACAAATGAGAAAGAAAAAATCACCAAGGAATTAAGAT
CTCGAATTTCAGATTTTTCTACTTACGAGCGAGAATTGAACAATTTAAAA
GCATCTCTAACTATTGCTGAGCAGAAGCTTAAAATGGAAAAAGTTCGTTT
TGAAGAAGAAATAGAAAAAAATAAAGAAACGAAAAAAAAGTACGAAGAAT
TGCAAAGAAACGTGTTGGTTCTGAAGGAAGAAAATAGTACTTTGCGTTCG
AACTGTCAGGAAATTGTCAAGAAATATCAAAATTCCGAAGACATGCTATC
AAACAGCTTGAGCACGAGTTTGAGACAAATGAAAGAAGAGCTGAAAAAAT
GTATGGAAGAAAAAAAGGAAGCTGTTGAAAATCACAGTAAAATATCCCTG
GAACTTCAAGTGAATAAATCTACTATCAATAGCTTAAATCAAGAGTTGAA
AAATTTGAAAGAAAAAATCAAACACTTGGAAGCCGATAAAATGTGCCAAG
AAGAAACTGTCAAACAACTGAAAGATGCAATCAAAAGTCTGACATTTATC
AAAGACCAGCTAACTGAACGAATAGCTAATTTAGAACCGTTTGAAAGTCG
CGTAGATCAAGTTACGCAGGAAAACGATCGTCTTATTGTGACAAATACTG
AACTGAGAAAAATCAGTGAAGATAACGAAGGAGTTCTTTCTACATTAAGA
CAAAAAGAATCAGAACTACTAGAATTTATTCAGTCTTTATCAAATAAAAA
TGCTGAATTACAGACTGAAAAACAAGAATTGTCAGAAGCAAAAGAAAAAT
CTCATACACAAATTTTGAAAGTCGATTTACAATATAAAGAGGCTGTTAAA
AAAATTAATTTCTGGGAAAATAAATCTAAAGCCGAGTCAAAGAGCTGGTT
AGAGGAACGAGAAGAATTATTAAAGCAGATTGATTATTTAACTGATGATC
TAAAACGTACCAATAATAAGTTATCAGATTCCAACGATCAAATTTATTCA
TTGCAGAAAAAACACAAGGCCCACATTAAAGATCTCATCAGACAATTGAC
AAAGTCAAATATGCCAGACATAAATAAAATAAATGAGAAAAAAGACATTG
TCAATCCCGTGTCGGGGAAATCAACACAGATGTCTTGCTCTGCCTCTGAT
GAGTCTGGAAATTCAAATCAAAATCTCACTGAAAAAGACGATTACAATGA
TTACAGTTTAAATCCAATTAAATCTCAATTTACTCCATTCACCAATGGGA
AAACTGAATATTATTCTAATTGCCAACCAATAACAAGTCCAATCCTATCC
ACCAGTCAACCCTTAGAGGTTCAGATGATTGAACCCCACAATCAAGTTTT
TATAGATAAAATTATTAGACTCCAACAATTCAATGCCAAATTACAAGAAA
AAATTGAATTCCTTACCGAGCATACTATTCAACTTACCCAAGATATTCAG
AGAAAATCATTACTAATACGGTATTTATTCAGTCAAACTGAAGAAAAAGG
TTCAGTGAAATCAGATTTAATTGACGACAATCATTCTATGATTGCTAGAA
AAGGAGGTATTATGGCGTCGGTATTTTCCAGTCGACAAGCAGATGAAAAC
ATGACGCTTGAATTATCGTTGGAAATAAATCGTCGTCTTCAAAGTGTATT
GGAAGACACTACGATTAAAAATTTTACTTTGAAAGACAGCATAAATACTT
TGGGAGAAGAAATCTCTAAATTGAGTTCAGAAAATCTCAGATTAAAGAAT
AATTTGAATGTGTCATGATAATAATTTATCTTATTGAATGTACATAAATA
TAAATTTCATTGATAGATTATTATAATTCCTCTCCTGTGATCTATTTCCG
TTTATGAAATTAACGGATGGAAGCAATATCCTAATTTTATAATCACCTGT
GACTTTTTTCTGTGATAATGCTGAGGATCTGTTTCAAACAAAAGCATTTT
TATTGTGTT
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protein sequence of SMED30000896-orf-1

>SMED30000896-orf-1 ID=SMED30000896-orf-1|Name=SMED30000896-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=721bp
MAEVDIACESSITDLEGQENKLESFNSKNEPENNNHTIEILTRTNKSLED
LLKVHNDDKIKMKEEIENLQGHLTNLKSELRIKVDHLTKIYEDEKHDKES
MVLKFAQAEQKNLDTLKKVKELEGRLRESKFNLDLVTNEKEKITKELRSR
ISDFSTYERELNNLKASLTIAEQKLKMEKVRFEEEIEKNKETKKKYEELQ
RNVLVLKEENSTLRSNCQEIVKKYQNSEDMLSNSLSTSLRQMKEELKKCM
EEKKEAVENHSKISLELQVNKSTINSLNQELKNLKEKIKHLEADKMCQEE
TVKQLKDAIKSLTFIKDQLTERIANLEPFESRVDQVTQENDRLIVTNTEL
RKISEDNEGVLSTLRQKESELLEFIQSLSNKNAELQTEKQELSEAKEKSH
TQILKVDLQYKEAVKKINFWENKSKAESKSWLEEREELLKQIDYLTDDLK
RTNNKLSDSNDQIYSLQKKHKAHIKDLIRQLTKSNMPDINKINEKKDIVN
PVSGKSTQMSCSASDESGNSNQNLTEKDDYNDYSLNPIKSQFTPFTNGKT
EYYSNCQPITSPILSTSQPLEVQMIEPHNQVFIDKIIRLQQFNAKLQEKI
EFLTEHTIQLTQDIQRKSLLIRYLFSQTEEKGSVKSDLIDDNHSMIARKG
GIMASVFSSRQADENMTLELSLEINRRLQSVLEDTTIKNFTLKDSINTLG
EEISKLSSENLRLKNNLNVS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR038830CCDC186
Vocabulary: molecular function
TermDefinition
GO:0003674molecular_function
Vocabulary: cellular component
TermDefinition
GO:0005575cellular_component
Vocabulary: biological process
TermDefinition
GO:0008150biological_process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 232..263
NoneNo IPR availableCOILSCoilCoilcoord: 154..216
NoneNo IPR availableCOILSCoilCoilcoord: 105..139
NoneNo IPR availableCOILSCoilCoilcoord: 435..469
NoneNo IPR availableCOILSCoilCoilcoord: 38..79
NoneNo IPR availableCOILSCoilCoilcoord: 267..322
NoneNo IPR availableCOILSCoilCoilcoord: 375..402
NoneNo IPR availableCOILSCoilCoilcoord: 696..716
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 503..522
IPR038830Coiled-coil domain-containing protein 186PANTHERPTHR18911CTCL TUMOR ANTIGEN HD-CL-01coord: 27..715