cGMP-dependent protein kinase

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I++LQ E++K  SV+     + ++    +S    + R+K+Q +S E      +D +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  L+KL ++LE   +E GE IIRQG   D FFII  G+V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPA--TQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWD 683          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            ++K  ++ L+EK   I+EL+R+++K  SVL            + S +     ++ QG+S E    ++         K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  L+KL ++LE   +E GE IIRQG   D FFII  G+V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   18 RIKELEKRLSEKEEEIQELKRKLHKCQSVLP-----------VPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWD 668          

Query:  773 AMGPYHSKHIES--------CFKHK--EISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELK--------NKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVK-----------LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P HSKH +           ++K  E+   LR    EI E E       LK  +E+L+++ + I EL  E+       NKL  V+             ++ LE +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G Y+I +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R E+   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G   EL+        N N +DEK    +S S   +     +E ++ +K            ++LE++ TLGVGGFGRVELV++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   ++    DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREY-----HLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLE-MIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKD 761          

Query:  773 AMGPYHSKHIES--------CFKHK--EISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELK--------NKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVK-----------LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P HSKH +           ++K  E+   LR    EI E E       LK  +E+L+++ + I EL  E+       NKL  V+             ++ LE +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G Y+I +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R E+   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G   EL+        N N +DEK    +S S   +     +E ++ +K            ++LE++ TLGVGGFGRVELV++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   ++    DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREY-----HLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLE-MIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKD 761          

Query:  773 AMGPYHSKHIES--------CFKHK--EISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELK--------NKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P HSKH +           ++K  E+   LR    EI E E       LK  +E+L+++ + I EL  E+       NKL  V+             ++ LE +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G Y+I +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R E+   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G   EL+        N N +DEK    +S S   +     +E ++ +K                  E V++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   ++    DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREY-----HLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLE-MIQLK------------------EKVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKD 732          

Query:  791 SKHIESCFKHKEISSVLRPIGDEIYEM-EIENLHNQLK----------LTQEELNEKNI-RIEEL-------QREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            S+H    F   +  + L  +G   +E  E++ L  QL+            Q+ + E +I RI EL       QRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:    5 SRHHMDSFSSNDGGAFLVQVGTRTFEAHELQKLIPQLEEAISRKDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 747          

Query:  791 SKHIESCFKHKEISSVLRPIGDEIYEM-EIENLHNQLK----------LTQEELNEKNI-RIEEL-------QREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            S+H    F   +  + L  +G   +E  E++ L  QL+            Q+ + E +I RI EL       QRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:    5 SRHHMDSFSSNDGGAFLVQVGTRTFEAHELQKLIPQLEEAISRKDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 747          

Query:  791 SKHIESCFKHKEISSVLRPIGDEIYEM-EIENLHNQLK----------LTQEELNEKNI-RIEEL-------QREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            S+H    F   +  + L  +G   +E  E++ L  QL+            Q+ + E +I RI EL       QRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:    5 SRHHMDSFSSNDGGAFLVQVGTRTFEAHELQKLIPQLEEAISRKDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 747          

Query:  938 IEELQREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            +  LQRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:   61 VTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 735          

Query:  938 IEELQREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            +  LQRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:   61 VTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 735          

Query: 1052 KKQGVSGES----NKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDA-KLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRY---DGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKL----VNVKLKDLELVCTLGVGGFGRVELVRLSH-DHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            KKQGVS ES     +   ++ + KY+K  S K  ++++I+ N  L N+   QV E+++ MY + I  G +VI EGE G HLYV+ +G+F V +  ++L  +   + FGELA+LYNC RTAS++ L++A ++WVLDR VFQ IMM TG+QR E  + FL+SVPLL  L E  L K+ ++LEL+ +  G  IIRQG + D FF+I  G+V+VTQ+      EE  +RTL+ G+YFGE+AL++ + RTAN+ A S   + L L R  F  LIGDL ELK K+Y DE   L+   ++ S C D   E+L     ++KL DLE+V TLG+GGFGRVELV+  H D    +ALKC+KK HIV TKQ++H+ SE+ I+L  RS FICRLY TF+D K+VYML+E C+GGE+WT LRD+  F+D   +F +GCVL+AF+YLH+RGIIYRDLKPENL++   GY+K+ DFGFAK+IG   +TWTFCGTPEYV+PEIILNK HD   DYW++GIL +ELL GTPPF+  DPM+ Y LILKGI+   I   + I+  A   I+ LC+   +ERLG   GG+++IK HK+F GFDW+ +  Q L+ PF   +   TD   FD F  +   PPDE SGWD +
Sbjct:  142 KKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQES-CRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDM--IAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDELSGWDAD 767          

Query: 1046 RSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVT--QRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLY--RKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNF 2839
            R +  G+S E   + +    ++   KY K    + L++ +IL N  + NL   Q+ E+++ MY  +      +I EG+ G  +YV E G  EV +  + L  L G +  GELA+LYNC+RTA++ A+T+  LW ++R+ FQ IMMRTG+ RQ E   FLKSVP+ K L E  L K+ ++LE   ++ G+ I+RQG   D FFII  G V+VT  Q+   EE+ IR L  G++FGEKAL   + RTAN+   S+   V CL   R+ F +LI +L+E+K++ Y+DE  +  +  +          E+  ++ L DL ++ TLGVGGFGRVELV+ + D   ++ALK MKK  IV+T+QQ H++SEK+I+ E    FI +L+ TFKD K++YMLME CLGGELWT LRDK +FDD  T+F   CV+EAFDYLHSR IIYRDLKPENLL+   GY+KL DFGFAK++  G++TWTFCGTPEYV+PE+ILN+ HD ++DYWS+G+L +ELLTGTPPFTG+DPM+ Y +ILKGI+A +    R IT  AS+ I+ LC+ N AERLG   GG+ EI+ HK+F GF W  ++   L  P  P V S  D +NF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESA-DGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKIN----------EEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEF--PRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNF 1066          

Query: 1046 RSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVT--QRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLY--RKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNF 2839
            R +  G+S E   + +    ++   KY K    + L++ +IL N  + NL   Q+ E+++ MY  +      +I EG+ G  +YV E G  EV +  + L  L G +  GELA+LYNC+RTA++ A+T+  LW ++R+ FQ IMMRTG+ RQ E   FLKSVP+ K L E  L K+ ++LE   ++ G+ I+RQG   D FFII  G V+VT  Q+   EE+ IR L  G++FGEKAL   + RTAN+   S+   V CL   R+ F +LI +L+E+K++ Y+DE  +  +  +          E+  ++ L DL ++ TLGVGGFGRVELV+ + D   ++ALK MKK  IV+T+QQ H++SEK+I+ E    FI +L+ TFKD K++YMLME CLGGELWT LRDK +FDD  T+F   CV+EAFDYLHSR IIYRDLKPENLL+   GY+KL DFGFAK++  G++TWTFCGTPEYV+PE+ILN+ HD ++DYWS+G+L +ELLTGTPPFTG+DPM+ Y +ILKGI+A +    R IT  AS+ I+ LC+ N AERLG   GG+ EI+ HK+F GF W  ++   L  P  P V S  D +NF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESA-DGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKIN----------EEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEF--PRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNF 1066          

Query: 1046 RSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVT--QRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLY--RKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNF 2839
            R +  G+S E   + +    ++   KY K    + L++ +IL N  + NL   Q+ E+++ MY  +      +I EG+ G  +YV E G  EV +  + L  L G +  GELA+LYNC+RTA++ A+T+  LW ++R+ FQ IMMRTG+ RQ E   FLKSVP+ K L E  L K+ ++LE   ++ G+ I+RQG   D FFII  G V+VT  Q+   EE+ IR L  G++FGEKAL   + RTAN+   S+   V CL   R+ F +LI +L+E+K++ Y+DE  +  +  +          E+  ++ L DL ++ TLGVGGFGRVELV+ + D   ++ALK MKK  IV+T+QQ H++SEK+I+ E    FI +L+ TFKD K++YMLME CLGGELWT LRDK +FDD  T+F   CV+EAFDYLHSR IIYRDLKPENLL+   GY+KL DFGFAK++  G++TWTFCGTPEYV+PE+ILN+ HD ++DYWS+G+L +ELLTGTPPFTG+DPM+ Y +ILKGI+A +    R IT  AS+ I+ LC+ N AERLG   GG+ EI+ HK+F GF W  ++   L  P  P V S  D +NF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESA-DGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKIN----------EEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEF--PRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNF 1066          

Query: 1046 RSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVT--QRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLY--RKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNF 2839
            R +  G+S E   + +    ++   KY K    + L++ +IL N  + NL   Q+ E+++ MY  +      +I EG+ G  +YV E G  EV +  + L  L G +  GELA+LYNC+RTA++ A+T+  LW ++R+ FQ IMMRTG+ RQ E   FLKSVP+ K L E  L K+ ++LE   ++ G+ I+RQG   D FFII  G V+VT  Q+   EE+ IR L  G++FGEKAL   + RTAN+   S+   V CL   R+ F +LI +L+E+K++ Y+DE  +  +  +          E+  ++ L DL ++ TLGVGGFGRVELV+ + D   ++ALK MKK  IV+T+QQ H++SEK+I+ E    FI +L+ TFKD K++YMLME CLGGELWT LRDK +FDD  T+F   CV+EAFDYLHSR IIYRDLKPENLL+   GY+KL DFGFAK++  G++TWTFCGTPEYV+PE+ILN+ HD ++DYWS+G+L +ELLTGTPPFTG+DPM+ Y +ILKGI+A +    R IT  AS+ I+ LC+ N AERLG   GG+ EI+ HK+F GF W  ++   L  P  P V S  D +NF
Sbjct:  129 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESA-DGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKIN----------EEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEF--PRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNF 720          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR--YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I++LQ E++K  SV+      +     +        R+K+Q +S E      +D +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  + D+   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+V+ LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  +GL E  L+KL ++LE   + +GE IIRQG   D FFII  G V VT+    +G    +R L  G++FGEKAL   + RTANV A  +VT  L + R+ F  LIG L+++ NK Y+D                +AE     N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A + I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L+ P  P V S TD SNFD F +D ++ PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQVHKQSALQE----HQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVT-CLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKY---------EAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWD 681          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKK-QGVSGE-----SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR--YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            ++K  +  L+ K   + EL+R+++K  SVL  T               I  R+++ QG+S E     S +D  +  L K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  + D+   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+V+ LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  +GL E  L+KL ++LE   + +GE IIRQG   D FFII  G V VT+    +G    +R L  G++FGEKAL   + RTANV A  +VT  L + R+ F  LIG L+++ NK Y+D                +AE     N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A + I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L+ P  P V S TD SNFD F +D ++ PPD+ SGWD
Sbjct:   18 RIKEMERLLSAKEQEVNELKRKLHKYQSVLPST---------------IGPRTRRAQGISAEPQTARSFQDLKSEALRKHHKSVRSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVT-CLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKY---------EAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWD 666          

Query:  908 QEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGE--SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR-YDGEEQV-IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +  L E+   I EL+R+++K  SVL   QI   ++             + QG+S E  +++D +N    +  KS+  K L++ +IL N  + NL   Q+ E+++ MY    D+   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+V+ ++  KLW +DR+ FQ IMMRTG+ +  E +  LKSV   +GLPE  L+KL ++LE   +E+G  IIRQG   D FFII  G V +T+    G+E V +R++  G+ FGEKAL   + RTANV A  +VT  L + R  +  LIG L ++ NK  ED +              +AE     N+ L D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+ +FDD  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A++ I+ LC+   +ERLGN   G+++I+ HK+F+GF+W+ +RK  L+ P  P VTSSTD SNFD F +D ++ PPD+ SGWD
Sbjct:   23 ERRLLEREDEISELKRKLHKCQSVLPSAQIGPRTH-------------RAQGISAEPQTHQDLSNQSFRRVAKSDRSKDLIKSAILDNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKALQGEDIRTANVIAAETVT-CLVIDRDSYKHLIGGLEDVSNKGCEDAEAKAKY---------EAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWD 664          

Query:  851 GDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLES--------NDMISSVNSIQ----------------------NRSK--KQGVSGESNK---DQTNLKLIKYK-----KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEE--QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKN--KNY-----EDEKHXXXXXXXXXXICNDAEMEKLVNVKLKD-----------LELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            G+ I  + +E L   LK   E+LN K ++I+ L+ ++ +    L +   +L S         D + S   +                       NR K  K GVS E +    D + +    ++     K  S+K LL +++ KN  L  L   QV +M+E MYER   +G YVI +GE G+HL+V   G  +V++  +LL  +     FGELA+LYNC RTASVKA ++ K W LDREVF  IM  T   R E+   FL+SV LL  LP  KL K+V+ LE++ + +G+ IIR+GE  + F+II +G +KVTQ     E  Q+I TL  G+YFGEKAL+S + R+AN+ A     + L + R+ F + +G  +ELK   ++Y      D+K   +K S   +  N      ++ +K ++           LE + TLGVGGFGRVELV+L +++  T+ALKC+KK HIV  +Q++H+ SE++ILLE    FI ++Y T+KD K+VYML+E CLGGE+W+ LRD+  F++   KFC+GCV EAFDYLH+ GIIYRDLKPENL++ T GY+KL DFGFAK++  G+RTWTFCGTPEYV+PEIILNK H  + D+WS+GIL +ELLTG+PPFTG+D M IYT ILKGIE  D    ++IT R    I+ LC+ N +ERLGN   G+ +IK H++F GF W  ++ ++L+SP   +V   TDHS FD +  E+E+PPDE SGWD +
Sbjct:   24 GESILRVRVEELETHLKKKDEDLNAKELQIKHLEEQLAQQKQTLSEISDTLRSKCLQLNKLQDALKSQGELGLLPSPLKEKVSQGLTGLLRETLNRRKGAKAGVSAEPSSRTYDSSGIPKFYFESARVWKEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVGTFDELKKYLQSYVDSLARDDKKRNAKRSGSCTPPNTPVSHDMIELKERESSFASTIPFTCLEAIATLGVGGFGRVELVKLKNEN-VTFALKCIKKRHIVDNRQEEHIYSERRILLETNCPFIVKMYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDF--PKKITKRPGDLIRKLCRQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKGPTDHSYFDSYPPEEEIPPDEMSGWDTD 763          

Query:  857 EIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLES--------NDMISSVNSIQ----------------------NRSK--KQGVSGESNK---DQTNLKLIKYK-----KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEE--QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKN--KNY-----EDEKHXXXXXXXXXXICNDAEMEKLVNVKLKD-----------LELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++  + +E L   LK   E+LN K ++I+ L+ ++ +    L +   +L S         D + S   +                       NR K  K GVS E +    D + +    ++     K  S+K LL +++ KN  L  L   QV +M+E MYER   +G YVI +GE G+HL+V   G  +V++  +LL  +     FGELA+LYNC RTASVKA ++ K W LDREVF  IM  T   R E+   FL+SV LL  LP  KL K+V+ LE++ + +G+ IIR+GE  + F+II +G +KVTQ     E  Q+I TL  G+YFGEKAL+S + R+AN+ A     + L + R+ F + +G  +ELK   ++Y      D+K   +K S   +  N      ++ +K ++           LE + TLGVGGFGRVELV+L +++  T+ALKC+KK HIV  +Q++H+ SE++ILLE    FI ++Y T+KD K+VYML+E CLGGE+W+ LRD+  F++   KFC+GCV EAFDYLH+ GIIYRDLKPENL++ T GY+KL DFGFAK++  G+RTWTFCGTPEYV+PEIILNK H  + D+WS+GIL +ELLTG+PPFTG+D M IYT ILKGIE  D    ++IT R    I+ LC+ N +ERLGN   G+ +IK H++F GF W  ++ ++L+SP   +V   TDHS FD +  E+E+PPDE SGWD +
Sbjct:   31 QVLRVRVEELETHLKKKDEDLNAKELQIKHLEEQLAQQKQTLSEISDTLRSKCLQLNKLQDALKSQGELGLLPSPLKEKVSQGLTGLLRETLNRRKGAKAGVSAEPSSRTYDSSGIPKFYFESARVWKEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVGTFDELKKYLQSYVDSLARDDKKRNAKRSGSCTPPNTPVSHDMIELKERESSFASTIPFTCLEAIATLGVGGFGRVELVKLKNEN-VTFALKCIKKRHIVDNRQEEHIYSERRILLETNCPFIVKMYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDF--PKKITKRPGDLIRKLCRQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKGPTDHSYFDSYPPEEEIPPDEMSGWDTD 768          

Query:  908 QEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRS-KKQGVSGE-----SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR-YDGEEQV-IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +  L+EK   I+EL+R+++K  SVL            + S + I  R+ + QG+S E     S  D T     K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  ++KL ++LE   +E G+ IIRQG   D FFII  G V VT+    GE+ + +RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +      N         +KL D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  FDD  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D ++ PPD+ SGWD
Sbjct:   23 ENRLSEKEKEIQELKRKLHKYQSVL-----------AMPSTSHIGPRTTRAQGISAEPQSFRSYHDLTRQAFKKFTKSERSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFGN---------LKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWD 670          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR-YDGEEQV-IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I+ LQ E++K  SV+      +   +        + R+K+Q +S E      ++ +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  ++KL ++LE   +E G+ IIRQG   D FFII  G V VT+    GE+ + +RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +      N         +KL D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  FDD  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D ++ PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQN---PTTLGEQRTKRQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFGN---------LKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWD 682          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR-YDGEEQV-IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I+ LQ E++K  SV+      +   +        + R+K+Q +S E      ++ +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  ++KL ++LE   +E G+ IIRQG   D FFII  G V VT+    GE+ + +RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +      N         +KL D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  FDD  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D ++ PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQN---PTTLGEQRTKRQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFGN---------LKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWD 682          

Query:  908 QEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSV------------------------------------NSIQNRSKKQGVSGE-------SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNEL--------KNKNYEDEK-HXXXXXXXXXXICNDAEMEKLVNV--------KLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            QE++ ++N  IEE+  E+      L++ Q+ +++ + IS+                                     NS + +  K+GVS E        +  + + +  + +K+ S K L+ +++ KN  +  +  +Q+ +M+E MYER   +G ++I +GE G  ++V   G  EV++  +LL  +     FGELA+LYNC RTASVKA+T  + W LDREVFQ IM +T   + EE L FLKSVPLLK LPE KL K+ + LEL+ +E  + IIR+GE    FFII  G VKVTQ  +G  E Q I+ L  G+YFGEKAL+S + R+AN+ A     + L + R+ F + +G   EL         N   +DE+ H  S  + +       E+ K+             ++LE+V TLGVGGFGRVELV++ +++   +ALKC+KK HIV  +QQ+H+ SEK IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+   KFC GCV EAF+YLH +G++YRDLKPENLL+ + GY+KL DFGFAK+I  G++TWTFCGTPEYV+PE+ILNK H F+ D+WS+GIL YELLTG+PPFTG D M IY LIL+GIE  + + N  IT R    I+ LC+ N AERLGN   G+ +IK H++F GF+WE +  + L SP  P++   TDHS FD +  ++E+PPDE SGWD++
Sbjct:   64 QEQIKKQNQVIEEMAEELQNKCVQLNKLQVVVQTQNGISTTPDLHKMLQPSPTKTLHALPTKSLKGSPLKTFSGLFSNSNKRKGAKEGVSAEPTSRYDGGDHPRFSFEKARVRKNTSEKILISDALNKNQFMKRMDHHQIQDMVECMYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQENKLLTSIPVWTTFGELAILYNCTRTASVKAITGVRTWALDREVFQNIMRKTAQSKHEEYLSFLKSVPLLKELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIISKGKVKVTQSTEGYKEPQYIKFLEKGDYFGEKALISDDVRSANILAYGDRVECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERRHAKSPVNERHLRAVSMELNKMKQTLARFPSASPFENLEIVTTLGVGGFGRVELVKVKNENL-VFALKCIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKN--ITKRPEDLIRRLCRENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPPDEEIPPDEVSGWDQD 786          

Query:  911 EELNEKNIRIEELQRE-------INKLTSVL--DQTQISLESNDMISSVNSIQNRSKKQGVSGES------NKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLE-LQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNK----------NYEDEKHXXXXXXXXXXICNDA--EMEKLVN-----VKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            +EL EK+ +I +L++E       I+KL   L  + TQ S + +     +++ + +  K+GVS E       N    N  +   +K +S K L+  +I+ N  L  L    V  M++ MYER   +   VI EG  G+HLYV   G  +V +  RLL  +     FGELA+LYNC+RTA+VKA+TD+K+WVLDR+VFQ IMM +   + +E   FL+      GL  + + +L+  ++    +++G+ IIR+GE  + FFII  G V VTQ  +G  E Q I+TL +G+YFGEKAL+S + R+AN+ A    T  L + R  F +++G   EL+            N  D ++        +S  N    ++ +LV+        + L+++ TLG GGFGRVELV+L  D   T+ALKC+KK HIV T QQ+HV  EK IL +    FI RLY TF+D K+VYML+EVCLGGELW+ LRD   F++   +FC GCVLEAFDYLH+RGI+YRDLKPENLL+ + GY+K+ DFGFAK+IG GK+TWTFCGTPEYV+PEII+N+ HDF +DYWS+GIL YELLTG+PPF+G DP+KIY ++LKGIE  D  H  RI  R+   I+ LC+ N AERLGN   G+ +I+ HK+FQGF+WE +R + L+SP   ++   TDHS FD+F  E E PPDE SGWD+
Sbjct:   53 KELQEKDEKILQLEKELEVKVIQIDKLQDALGYNVTQTSPKGSQKKKLLSAHRRQKAKEGVSAEPTSRHYYNPSSQNPDVTCVRKDSSAKKLITGAIMSNDFLRQLEASHVRCMVDCMYERVYSKSQLVIQEGAAGNHLYVLADGLLDVIQNSRLLGQMHPGTAFGELAILYNCKRTATVKAVTDSKIWVLDRQVFQNIMMSSAQAQHQEYFSFLRRYV---GLFSVMIYRLLYTIKNTDFYDKGDYIIREGEEGNTFFIIAKGKVCVTQAVEGSQEPQEIKTLGVGDYFGEKALISEDVRSANIIAEEDDTQCLVIDRDTFNQMVGTYQELQTYLREYVFQLALNDHDRRNARKSLHHSMSRDNSEVNQLRELVSKFSSTSPFRYLDVITTLGTGGFGRVELVKLK-DEDMTFALKCIKKKHIVDTHQQEHVYWEKNILQQINCSFIIRLYRTFRDAKYVYMLLEVCLGGELWSILRDTGPFEEGTARFCTGCVLEAFDYLHNRGIVYRDLKPENLLLDSEGYIKMVDFGFAKKIGPGKKTWTFCGTPEYVAPEIIMNRGHDFGADYWSLGILIYELLTGSPPFSGTDPIKIYNMVLKGIEKVDFPH--RIGRRSEDVIRRLCRINPAERLGNRKNGISDIRKHKWFQGFNWEGLRNRKLLSPLKREIKGITDHSYFDNFLPESEEPPDELSGWDK 743          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I++LQ E++K  SV+     + ++    +S    + R+K+Q +S E      +D +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LP+  L+KL ++LE   +E GE IIRQG   D FFII  G V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPA--TQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWD 683          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            ++K  ++ L+EK   I+EL+R+++K  SVL            + S +     ++ QG+S E    ++         K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LP+  L+KL ++LE   +E GE IIRQG   D FFII  G V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   18 RIKELEKRLSEKEEEIQELKRKLHKCQSVLP-----------VPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWD 668          

Query:  773 AMGPYHSKHIES---CFKHKEISSVLRPIGDEIY--EMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNK--------NYEDEKHXXXXXXXXXXICNDAEMEKLVNVK-----------LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P H+KH +       ++ + S +  +  E+   + E++     LK  +E+L ++ + I EL  E+       NKL  V+             ++ L+ +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G YVI +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R EE   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G  +EL+          N +DEK    +S S   +     +E ++ +K            ++LE++ TLGVGGFGRVELV++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   +++   DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHAKHPDGHSGNLSNEALRSKVLELERELRRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLE-MIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKD 761          

Query:  773 AMGPYHSKHIES---CFKHKEISSVLRPIGDEIY--EMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNK--------NYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P H+KH +       ++ + S +  +  E+   + E++     LK  +E+L ++ + I EL  E+       NKL  V+             ++ L+ +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G YVI +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R EE   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G  +EL+          N +DEK    +S S   +     +E ++ +K                  E V++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   +++   DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHAKHPDGHSGNLSNEALRSKVLELERELRRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLE-MIQLK------------------EKVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKD 732          

Query: 1751 ETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC                     ++F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   31 DVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLC---------------------RWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWD 379          

Query:  791 SKHIESCFKHKEISSVLRPIGDEIYEM-EIENLHNQLK----------LTQEELNEKNI-RIEEL-------QREINKLTSVLDQTQISLE---------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            S+H    F   + ++ L  +G   +E  E++ L  QL+            Q+ + E +I RI EL       QRE +KL SVL+Q   S                  ND+    +   +  Q R+KK  VS E +N +     L  Y K+ + K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +    L  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +++ FL  V +   L E +++K+ ++++   ++ G  I+RQGE  D FF+I SG VKVTQ+ +GE++   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL+ L+ K+Y D++ + +      S V I +D   E+  NV LK+++ + TLGVGGFGRVELV ++ D   TYALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  SGYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV +  D +NFD++  ++++PPDE+SGWDE
Sbjct:    5 SRHHLDSFSSNDGNAFLVQVGSRTFEAHELQKLIPQLEEAISRKDAQLRQQQSIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGQPPSPSPRTDQLGNDLQQKAVFPADGTQQRAKKIAVSAEPTNFENKPATLQHYNKTVAAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGATLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQIINFLSKVSIFANLTEDRISKIADVMDQDYYDGGHYILRQGEKGDAFFVINSGQVKVTQQIEGEKEAREIRILNQGDFFGERALLGDEVRTANIIAQAPGVEVLTLDRESFTKLIGDLDTLR-KDYGDKERVATLVREPPSPVKIVDDFR-EEFANVTLKNVKRLATLGVGGFGRVELVCVNGDKSKTYALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANSGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRTKTLKPPILPKVNNPADVTNFDNYPPDNDVPPDEFSGWDE 747          

Query:  938 IEELQREINKLTSVLDQTQISLE----------------SNDM----ISSVNSIQNRSKKQGVSGE-SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQV--IRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXX---XXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            +  LQRE +KL SVL+Q   S                   ND+    +   + +Q R+KK  VS E +N +     L  Y K+   K ++R+++ KN  L  L   Q+ E++  MYE +   G +VI EGE GD L+V   G+ +V +   LL  +      GELA+LYNC RTASV+ALTD +LWVLDR VFQ I  R G++R  +L+ FL  V + + L E +++K+ ++++   ++ G  IIRQGE  D FF+I SG VKVTQ+ +GE +   IR L  G++FGE+ALL  E RTAN+ A +   +VL L R+ F +LIGDL  LK K+Y D++ L        S V I +D   E+   V LK+++ + TLGVGGFGRVELV ++ D   T+ALK +KK HIV T+QQ+H+ +E+ I++E  + +I +LY TF+D KFVYML+EVCLGGELWT LRD+ HFDD   +F + CVLE  +YLH + I+YRDLKPEN L+  +GYLKL DFGFAK++  G++TWTFCGTPEYVSPEIILNK HD  +DYW++GI   EL+ G PPF  +DPMK YTLILKG++A +I  NRRI   A++ ++ LC+ N  ERLG+G+GG+ +I+ H++F GFDWE +R + L  P  PKV++  D +NFD++  ++++PPDE+SGWDE
Sbjct:  104 VTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQ-RAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFR-EEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDE 778          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            ++K  ++ L+EK   I+EL+R+++K  SVL            + S +     ++ QG+S E    ++         K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  L+KL ++LE   +E GE IIRQG   D FFII  G+V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   18 RIKELEKRLSEKEEEIQELKRKLHKCQSVLP-----------VPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWD 668          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQT----NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            ++K  ++ L+EK   I+EL+R+++K  SVL            + S +     ++ QG+S E    ++         K+ KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK L + KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  + LPE  L+KL ++LE   +E GE IIRQG   D FFII  G V VT+     E  +  RTL  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ NK YED +      +               N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK+I+    S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++I   A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V S TD SNFD F +D DE PPD+ SGWD
Sbjct:   18 RIKELEKRLSEKEEEIQELKRKLHKCQSVLP-----------VPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF---------FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWD 668          

Query:  773 AMGPYHSKHIES--------CFKHK--EISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREI-------NKLTSVL----------DQTQISLESNDMISSVNSIQNR-SKKQGVSGESNKDQTNL--------KLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELK--------NKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVK-----------LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++ P HSKH +           ++K  E+   LR    EI E E       LK  +E+L+++ + I EL  E+       NKL  V+             ++ LE +   S + S+ +R   K GVS E      +L        +  + +K +S K L+ +++ KN  L  L   Q+ +M+E MY R   +G Y+I +GE G+H++V   G  EV++ E+LL  +     FGELA+LYNC RTASVKA+T+ K W LDREVFQ IM RT   R E+   FL+SV LLK LPE KL K+++ LE++ +++G+ IIR+GE    FFI+  G VKVTQ  +G  + Q+I+TL  GEYFGEKAL+S + R+AN+ A  +    L + R+ F + +G   EL+        N N +DEK    +S S   +     +E ++ +K            ++LE++ TLGVGGFGRVELV++ +++ + +A+KC++K HIV TKQQ+HV SEK+IL E  S FI +LY TFKD K+VYML+E CLGGELW+ LRD+  FD+  +KFC+ CV EAFDYLH  GIIYRDLKPENL++   GYLKL DFGFAK+IG G++TWTFCGTPEYV+PE+ILNK HDF+ D+WS+GIL YELLTG PPF+G D M  Y LILKGIE  D    R+IT R    I+ LC+ N  ERLGN   G+ +IK H++  GF+WE ++ + L SP   ++    DHS FD +  E  +PPDE SGWD++
Sbjct:    5 SVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREY-----HLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLE-MIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA-FAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDF--PRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKD 761          

Query:  857 EIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSV--NSIQ----NRSKKQGVSGES-NKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDA--EMEK-LVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            E Y+ ++E+L   L   + +       +++L+REI+KL SVL+ T       D+++++  +S+      R KKQGVSGES N  ++++ L  + K    K L++++IL N  L NL   Q+ E+I+ MYER   +G ++I EGE G HL+V+  G+  V K  R L  +   R FGELA+LYNC RTASVKAL+DA+LWVLDR VFQAIMM+TG+QRQ E ++FL+SV LLK LP  KL K+  +LE+    EGECIIR+GE+ D FFII  G V+V Q+  G  + Q IR L  G+YFGEKALLS + RTA+V A +   + L + R+ F +LIGDLNEL+ K+Y DE     ++S      +    +ME+ L NV L  LE++ TLG+GGFGRVEL++LS D   TYALKC+KK HIV+T+QQ+H+ SEKKI++  RS FI RLY TFKD K+VYMLME CLGGELWT LRD+ HFD++  +FC+ CV+EAFDYLHS+GIIYRDLKPENLL+ T GY+KL DFGFAKR+G G +TWTFCGTPEYV+PEIILNK HD   DYWS+GIL YELLTG+PPF+ +DPMK Y +ILKGI+  +    + I   A + I+ LC+ N AERLG    G+ +IK HK+FQGFDW  + +Q L  P  P+V   TD SNFD++  + ++P DE SGWD +
Sbjct:   65 EQYQYQVEDLTKSLAFKEND-------VQKLEREIDKLRSVLELTVHKDGKPDILATIQEDSVMVGQATRGKKQGVSGESTNFSRSSVALKHFDKDFRSKQLIKDAILDNDFLKNLDKAQLREVIDCMYERTTQKGQFIITEGEAGQHLFVSAEGELNVLKDGRSLGTMTAGRAFGELAILYNCTRTASVKALSDARLWVLDRSVFQAIMMKTGLQRQAENIKFLRSVSLLKRLPSEKLAKIASVLEMDFFHEGECIIREGEAGDTFFIINKGEVEVQQKLKGFSDPQKIRNLKRGDYFGEKALLSEDYRTASVVAKAPGVECLTIDRESFTQLIGDLNELREKDYGDEARNAQRASESDIPASPGRQKMERELANVGLHQLEVLATLGLGGFGRVELIQLSTDRTKTYALKCLKKKHIVETRQQEHIYSEKKIMMNARSNFIARLYRTFKDNKYVYMLMEACLGGELWTILRDRGHFDEVTARFCVACVIEAFDYLHSKGIIYRDLKPENLLLDTKGYVKLVDFGFAKRVGHGSKTWTFCGTPEYVAPEIILNKGHDHAVDYWSLGILMYELLTGSPPFSTSDPMKTYNIILKGIDVVEF--TQHIRKNAQNLIKKLCRDNPAERLGYQKNGIADIKKHKWFQGFDWHGLHRQILTPPIQPRVRGPTDFSNFDNYPKDKDIPQDELSGWDND 748          

Query:  824 EISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQN-------RSKKQGVSGESNKDQT-NLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEE--QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICN---DAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            E+ S L+    +I ++EIE+     +   +++NE N  I  L+ E++KL SVL          D+++++   +        RSKKQGVSGES+ +   N++L  + K    K L++++IL N  L NL + QV E+++ MY+++I  G Y+I EGE G+HLYV+  G+ EV K   +L  +   R FGELA+LYNC RTASVKALT+ ++WVLDR +FQAIMM+TGIQR++E +R+L+SVPLL+ LP  KL KL ++LE+  + EGE IIR+G + D FFI+  G VKVTQR  G    Q IR L  G+YFGEK+LLS + RTANV A     + L + R  F +LIGDLNEL+ K+Y DE    S+ S +++  +   D  +E+ VN+K+ DL++V TLG+GGFGRVELV+LS+D   TYALKC+KK HIV T+QQ+H+ SEK+I+L  R+ FI RL+ TF+D K+VYM+ME CLGGELWT LRD+  FDD  T+F + CV+EAF YLH +GIIYRDLKPENLL+   GY+KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD  +DYWS+GIL +ELLTG+PPF+G+DPMK Y +ILKGI+  +    R+I+  A + I+ LC+    ERLG G  G+ +IK HK+FQGFDWE +    +  P  PKV + TD+SNFD +  ++++P DE SGWD +
Sbjct:   28 EMKSELKDKDAKIRKLEIES-----RDKTKQINENNKEITRLKEEVHKLKSVLQLKVHKDGKPDILATIQETEPPVVVQEVRSKKQGVSGESSSNSQSNVELKHHDKDFRSKQLIKDAILDNDFLKNLDSTQVREIVDCMYDKKIKEGHYIIKEGESGNHLYVSADGEVEVQKEGTILGRMASGRAFGELAILYNCTRTASVKALTEVRVWVLDRAMFQAIMMKTGIQRRDENIRYLRSVPLLRDLPADKLAKLADVLEIDFYHEGEYIIREGATGDSFFILNKGEVKVTQRIQGHNNPQEIRKLKRGDYFGEKSLLSEDRRTANVIALPPGVECLTVDRDSFNQLIGDLNELRTKDYGDEARGASRLSGELTPGSRDKDRILEEFVNIKIDDLDVVATLGMGGFGRVELVQLSNDKMKTYALKCLKKKHIVDTRQQEHIYSEKQIMLTSRTPFIARLFKTFRDNKYVYMMMEACLGGELWTILRDRGSFDDKTTRFYVSCVVEAFKYLHHKGIIYRDLKPENLLLDNKGYIKLVDFGFAKKIGAGKKTWTFCGTPEYVAPEIILNKGHDHAADYWSLGILMFELLTGSPPFSGSDPMKTYNIILKGIDVIEF--PRKISRNAHALIKKLCRDAPVERLGYGKNGITDIKKHKWFQGFDWEGLLNHSITPPIIPKVKNPTDYSNFDSYPKDNDIPADETSGWDAD 725          

Query:  866 EMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSV---NSIQNR--------SKKQGVSGESNK---DQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWD 2893
            E+   NLH +L  +++E++ K  ++ +LQRE++KL SVL Q       +D+++S+   +++ NR        +KKQGVS ES+       ++ + K++K    K L++++I+ N  L +L + QV E+++ MY RQ + G YVI EG+ G HLYV+  GDFEV K +++L  +   + FGELA+LYNC RTAS++ +TD+K+WVLDR+VFQ IM+RTG+QR ++ + FL+SVPLL  L    L K+ ++LE++ +  G  I+RQG S D FFII SG+VK+TQR  G  +E+ IRTLT G+YFGE+ALL  E RTA+V A S   + L L R+ F++LIGDL+  K K+Y D++ +L + SS  S+C  AE ++   ++L DL+++ TLGVGGFGRVELV+ ++D   T+ALKC+KK HIV T+QQDH+ SEK I++ CRS FICRLY TF+D K+VYML+E CLGGE+WT LRD+  FDD  T+F   CV+EAFDYLH+RGIIYRDLKPENLL+   GY+KL DFGF+KR+G   +TWTFCGTPEYV+PE ILNK HD   DYW++GIL YELLTG+PPFT +DPMK Y LILKGI+  D F    ++  A S I+ LC+   +ERLG   GG+++IK HK+FQGFDW+ +R + L  P    V    D SNFD F  + ++PPDE S WD
Sbjct:  256 EVNYGNLHTKLLESRKEVHSKESQVIKLQREVHKLKSVLQQATCFSNESDILTSLQEQHAMANRVPPAAVTFNKKQGVSAESSDIIGPAGDIHVQKHEKDFRSKQLIKDAIMDNNFLKHLDSLQVREIVDSMYPRQCEAGSYVIREGDAGAHLYVSAEGDFEVIKDDKVLGRMGSGKAFGELAILYNCTRTASIRVVTDSKVWVLDRKVFQQIMVRTGLQRLQDNINFLRSVPLLANLSNDVLAKIADVLEVEFYPSGAYIVRQGASGDTFFIISSGNVKITQRISGGLDEEDIRTLTRGDYFGEQALLREECRTASVIAMSPGVECLTLDRESFIQLIGDLSVFKEKDYGDDQRMLMRPSSVASVC--AEKQEYDYMRLDDLDIIATLGVGGFGRVELVQYANDQSMTFALKCLKKQHIVDTQQQDHIFSEKMIMMCCRSPFICRLYRTFRDSKYVYMLLEACLGGEVWTILRDRACFDDHTTRFITACVIEAFDYLHNRGIIYRDLKPENLLLDNDGYVKLVDFGFSKRLGYSSKTWTFCGTPEYVAPETILNKGHDRAVDYWALGILMYELLTGSPPFTASDPMKTYNLILKGIDMID-FEKHNVSRSAQSLIKKLCRDLPSERLGYQRGGIQDIKKHKWFQGFDWDGLRARSLPVPITKLVRGPCDTSNFDCFDKDVDIPPDELSDWD 944          

Query:  827 ISSVLRPIGDEIYEME--IENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVN-------------SIQNRSKKQGVSGESNKDQTN---LKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWD 2893
            + +++  + +E  E E  I+ L  ++   ++EL +K+    +L REI+KL SVL   ++     D++SS+              +I N +KKQGVSGES+    N   +++ +++K    K L++++IL+N  L NL T QV E++E +Y ++  +G YV+ EGE G HLYV+  G+ EV K + +L  +   + FGELA+LYNCRRTAS+K ++DAK+WVLDR+VFQ IMM+TG+QR +E L FL+SVPLL+ L    L K+ ++LE+  +  GE IIRQG + D FFII SGSVKVTQ   G  EE+ IR L  G+YFGE+ALL  + RTANV A S   +VL L R+ F++LIGDL+EL+ K+Y DE    +K SS  S+ +  E E    ++L+DL+++ TLGVGGFGRVELV+ S +    +ALKC+KK HIV+T+QQ+HV SEK I++ C S FICRLY TFKD K+VYML E  LGGE+WT LR+K  FDD  TKF   CV+EAF+YLH+RGI+YRDLKPENLL+ + GY KL DFGF+KRIG   +TWTFCGTPEY++PEIILNK HD   DYWS+GIL +ELLTG PPF   DPM+ Y +ILKGI+  D    + IT  A S I+ LC+ + +ERLG   GG+++IK HK+FQGFDW  ++++ L+ P  P V S TD SNFD +  E  +PPDE+S WD
Sbjct:  339 LRTIVASLSNETNEQEEKIDFLQTEIFYLRKELKKKDRENVKLHREIHKLKSVLQDARVFKREGDLLSSLQESHGMPGQFQQVINIPNPNKKQGVSGESSDHGQNHHQIEIQRFEKDFRSKQLIKDAILENNFLKNLDTVQVREIVESVYPKKFSKGDYVVREGEAGSHLYVSAEGELEVIKDQNVLGRMGPGKAFGELAILYNCRRTASIKVVSDAKVWVLDRQVFQKIMMKTGLQRLQENLNFLRSVPLLQSLNNEVLAKIADVLEVDFYPSGEHIIRQGATGDTFFIISSGSVKVTQEKPGKDEEEEIRILNKGDYFGEQALLKEDCRTANVIALSPGVEVLTLDRESFIQLIGDLSELQEKDYGDESRNFAKFSSCSSLTDKQEFE---YIRLQDLDIITTLGVGGFGRVELVQYSKNKSMAFALKCLKKQHIVETRQQEHVYSEKNIMMACNSPFICRLYRTFKDSKYVYMLQEALLGGEVWTILREKGCFDDYTTKFITACVIEAFEYLHTRGIVYRDLKPENLLLDSIGYTKLVDFGFSKRIGFSSKTWTFCGTPEYLAPEIILNKGHDRAVDYWSLGILMHELLTGIPPFAAPDPMRTYNIILKGIDVIDF--PKHITKGAQSLIKRLCRDSPSERLGYQRGGIQDIKKHKWFQGFDWSGLKQRALIPPVAPIVRSPTDTSNFDSYSKETVVPPDEFSCWD 1042          

Query:  827 ISSVLRPIGDEIYEMEIE--NLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSV---NSIQNRS-------------KKQGVSGESNKD---QTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG---EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            + +++  +  ++ E+E++  +L ++L  T+ +L  K   + +LQREI+KL SVL QT   ++  D+++S+   +++ NR+             KKQGVS ES++     +++ + K+ K    K L++++I+ N  L NL T QV E+++ MY ++  +G YVI EGE G HL+V+  GDFEV K +++L ++   + FGELA+LYNC RTAS++ + D+K+WVLDR+VFQ IM+RTG+QR ++ + FL+SVPLL+ L    L K+ ++LE++ +  G  IIRQG + D FFII SGSVKVTQR  G   +E+ IR L  G+YFGE+ALL  + RTAN+ A +   + L L R+ F +LIGDL+E+K KNY DE+ L  + +S    C  AE  +   + L DLE++ TLG+GGFGRVELV+  H+   T+ALKC+KK HIV T+QQDH+ SE+ I++ CRS FICR+Y TFKD K+VYML+E CLGGE+WT LRD+  FD+  TKF  GCVLEAFDYLHSRGIIYRDLKPENLL+  +GY+KL DFGF+KR+G   +TWTFCGTPEYV+PE ILNK HD   DYW++GIL +ELLTG PPFT +DPMK Y LILKGI+  D F    I   A S I+ LC+   +ERLG   GG+++IK HK+FQGFDW+ +  Q L SP    V    D +NFD F  ++++PPDE S WD E
Sbjct:  239 LKTIVARLKKDLAELEVKYGSLQSELYETRRQLTCKESEVLKLQREIHKLKSVLQQTTTFIQDGDILTSLQEKHAMANRAPQSQQSLTNSCVLKKQGVSAESSESTGQASDITIPKHDKDFRSKQLIKDAIMDNNFLQNLDTSQVREIVDCMYLKEYPQGSYVIKEGEAGAHLFVSAEGDFEVMKEDKVLGHMGPGKAFGELAILYNCTRTASIRVVVDSKVWVLDRKVFQQIMVRTGLQRLQDNINFLRSVPLLQNLSNEVLAKIADVLEVEFYPAGVYIIRQGANGDTFFIISSGSVKVTQRKQGSMEDEEEIRILQRGDYFGEQALLKEDCRTANIIAMNPGVECLTLDRESFKQLIGDLSEIKEKNYGDEQRLNRQINST---C--AENSEYDYISLDDLEVIATLGIGGFGRVELVQYVHNPSLTFALKCLKKQHIVDTQQQDHIFSERNIMMSCRSSFICRMYKTFKDSKYVYMLLEACLGGEVWTILRDRGCFDEDTTKFITGCVLEAFDYLHSRGIIYRDLKPENLLLDANGYVKLVDFGFSKRLGYSSKTWTFCGTPEYVAPETILNKGHDRAVDYWALGILMHELLTGNPPFTASDPMKTYNLILKGIDMID-FAKHHIGRAAQSLIKKLCRDAPSERLGYQKGGIQDIKKHKWFQGFDWDGLVNQTLPSPIRQPVRGCCDTTNFDCFGKDNDIPPDELSNWDLE 947          

Query:  878 ENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGE-----SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVI--RTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            E+L   L L +E + E  +R+ E + EI +L   L + Q  L S  ++          + QG+S E     S +  T+  L K+ KS+  K L++E+IL N  + NL   Q+ E+            C +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+V+ LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP  +GL E  L+KL ++LE   +++GE IIRQG   D FFII  G V VT+     +  +  R L  G++FGEKAL   + RTANV A  +VT  L + R  F  LIG L+++ +K YED                +AE     N+KL D  ++ TLGVGGFGRVELV+L  +   T+A+K +KK HIV T+QQ+H+ SEK I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A++ I+ LC+ N +ERLGN   G+++I+ HK+F+GF+WE +RK  L  P  P V+S TD SNFD F +D ++ PPD+ SGWD
Sbjct:    6 EDLARLLLLKEERIREMELRLAEKEEEIAELKRKLHKCQSVLPSAPLMGP-----RTRRAQGISAEPQPFTSFQQLTSEALRKHAKSDRSKELIKEAILDNDFMKNLELSQIQEI----------ESC-IIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLAEEILSKLADVLEETHYDDGEYIIRQGARGDTFFIISKGKVNVTREDSPSDTPVYLRALGKGDWFGEKALQGEDIRTANVIAADAVT-CLVIDRDSFKHLIGGLDDVSSKGYEDAGAKAKY---------EAENAFFSNLKLADFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKHIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPDVSSPTDTSNFDSFPEDSEDPPPDDNSGWD 657          

Query:  851 GDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESN-----------------DMISSVNSIQ---------------NRSKKQGVSGESNK---DQTNLKLIKYK-----KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRY-DGEE-QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKN--KNY------EDEKHXXXXXXXXXXICNDAEMEKL--------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWD 2893
            G +I  M++E L  QLK   EELN + ++I++L+ ++ +    +     +L +                  +++SS    +                +  K GVS E +    D +++    ++     K  S+K LL +++ KN  L  L   Q+ +M+E MYER   +G +VI +GE G+HL+V   G+ +V++  +LL  +     FGELA+LYNC RTASVKA +  + WVLDREVF  IM  T   R E+   FL+SV LL  LPE KL K+V+ LE++ +++G+ +IR+GE  + F+II  G VKVTQ   D EE QVI TL  G+YFGEKAL+S + R+AN+ A+    + L + R+ F + +G  +ELK   + Y      +D+K    +S S     +   ++++          +   +LE++ TLG+GGFGRVELV++ +++  T+ALKC+KK HIV  +Q++H+ SE++IL E  S FI ++Y TFKD K+VYML+E CLGGE+W+ LRD+  F++   KFC+GCV EAF+YLH++ IIYRDLKPENL++ + GY+KL DFGFAK++  G++TWTFCGTPEYV+PEIILNK H  + D+W++GIL +ELLTG+PPFTG+D M  YT ILKG+E  D    ++I+ R    I+ LCK N +ERLGN   G+ +IK H++F GF W  ++ + L SP   +V   TDHS FD++  EDE+PPDE SGWD
Sbjct:   29 GPQILRMKVEELEAQLKKKDEELNAQQLQIKQLEDQLAQQNQAIADISDALRNKCFQLTKLQEALKNQGDLELLSSPTKTKFSQRLSGLLRETLNKRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHEEPQVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELVKVKNEN-VTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDF--PKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWD 764          

Query:  857 EIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDM--------------ISSVNSIQNR------------SKKQGVSGESNK---------DQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYE--------DEKHXXXXXXXXXXICNDAEMEKLVNVK---------LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            E  ++ I  L  +L    +EL  + ++++ LQRE+      +D+ Q ++  N++              +S +N    R              K+GVS E               +++  + +K + IK L+ E+I+ N  L  L      EM++ MYE+       VI EGE G++LYV   G  EV +  +LL  +     FGELA+LYNC+RTA+VKA+T + +W LDR+ FQ+IMMR+   R EE   FL+SV LLK LPE KL K+V+ LE+   ++GE IIR+GE  + FFII  G V VTQ  +G  E   I+ L +G+YFGEKAL+S + R+AN+ A  + T  L + R  F +++G   EL+    E        DE+ + +  S        A   + ++ K         L+ L+++ TLG+GGFGRVELV+L ++  + +ALKC+KK HIV T+QQ+H+ SEK IL +    FI RL+ TF+D K+VYML+EVCLGGELW+ LRD   F++   +FC+GCVLEAFDYLH  GI+YRDLKPENLL+   GY+K+ DFGFAKRIG+GK+TWTFCGTPEYV+PE+I+NK HDF +D WS+GIL +ELL G+PPF+G+DP+KIYT++L GIE  DI   +RI+ R    I+ LCK N AERLGN   G+ +IK HK+FQGF+WE +R++ L SP   ++    DHS+FD F  E E PPDE SGWD++
Sbjct:   38 EHLKLRIARLEEELARRDQELRAQELQLQTLQRELEAKVLQIDKLQDAIGYNNLGRSPPAPARPSHRLLSVINQGSTRFHRVAVEVHRRLKAKEGVSAEPTSGHFCKEHRTQHVSIERTRIRKDSGIKKLINEAIMNNDFLKKLEPQHTREMVDCMYEKVYTANQLVIQEGEPGNYLYVLAEGLLEVIQNGKLLGQMRPGTAFGELAILYNCKRTATVKAVTQSHIWALDRQTFQSIMMRSTQARHEEYFSFLRSVSLLKDLPEEKLAKIVDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQSTEGYSEPLEIKILGVGDYFGEKALISEDVRSANIIAKENDTQCLVVDRDNFNQMVGTYEELQAYLREYVEQLSINDERRIAATQSPLYERSPQAAELRSLHEKAARLSSCSFLQQLQIIATLGMGGFGRVELVKLKNE-DTAFALKCIKKKHIVDTRQQEHIYSEKNILQQTNCNFIVRLFRTFRDEKYVYMLLEVCLGGELWSVLRDMSFFEEATARFCIGCVLEAFDYLHGMGIVYRDLKPENLLLDAEGYVKMTDFGFAKRIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFSGSDPIKIYTMVLHGIEKVDI--PKRISKRPEDLIRRLCKLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLASPLRRELNGPLDHSHFDMFPPELEEPPDELSGWDKD 769          

Query:  851 GDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESN-----------------DMISSVNSIQ---------------NRSKKQGVSGESNK---DQTNLKLIKYK-----KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRY-DGEE-QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWD 2893
            G +I  M++E L  QLK   EELN + ++I++L+ ++ +    +     +L +                  +++SS    +                +  K GVS E +    D +++    ++     K  S+K LL +++ KN  L  L   Q+ +M+E MYER   +G +VI +GE G+HL+V   G+ +V++  +LL  +     FGELA+LYNC RTASVKA +  + WVLDREVF  IM  T   R E+   FL+SV LL  LPE KL K+V+ LE++ +++G+ +IR+GE  + F+II  G VKVTQ   D EE QVI TL  G+YFGEKAL+S + R+AN+ A+    + L + R+ F + +G  +ELK                +  +   A  +K  N K   L  VC+  V             +   T+ALKC+KK HIV  +Q++H+ SE++IL E  S FI ++Y TFKD K+VYML+E CLGGE+W+ LRD+  F++   KFC+GCV EAF+YLH++ IIYRDLKPENL++ + GY+KL DFGFAK++  G++TWTFCGTPEYV+PEIILNK H  + D+W++GIL +ELLTG+PPFTG+D M  YT ILKG+E  D    ++I+ R    I+ LCK N +ERLGN   G+ +IK H++F GF W  ++ + L SP   +V   TDHS FD++  EDE+PPDE SGWD
Sbjct:   29 GPQILRMKVEELEAQLKKKDEELNAQQLQIKQLEDQLAQQNQAIADISDALRNKCFQLTKLQEALKNQGDLELLSSPTKTKFSQRLSGLLRETLNKRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHEEPQVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTFDELKK-------------YLQGYVETLARDDKKRNAKWF-LIAVCSSQVK----------VKNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDF--PKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWD 725          

Query:  851 GDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESN-----------------DMISSVNSIQ---------------NRSKKQGVSGESNK---DQTNLKLIKYK-----KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRY-DGEE-QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKN--KNY------EDEKHXXXXXXXXXXICNDAEMEKL--------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWD 2893
            G +I  M++E L  QLK   EELN + ++I++L+ ++ +    +     +L +                  +++SS    +                +  K GVS E +    D +++    ++     K  S+K LL +++ KN  L  L   Q+ +M+E MYER   +G +VI +GE G+HL+V   G+ +V++  +LL  +     FGELA+LYNC RTASVKA +  + WVLDREVF  IM  T   R E+   FL+SV LL  LPE KL K+V+ LE+                          VKVTQ   D EE QVI TL  G+YFGEKAL+S + R+AN+ A+    + L + R+ F + +G  +ELK   + Y      +D+K    +S S     +   ++++          +   +LE++ TLG+GGFGRVELV++ +++  T+ALKC+KK HIV  +Q++H+ SE++IL E  S FI ++Y TFKD K+VYML+E CLGGE+W+ LRD+  F++   KFC+GCV EAF+YLH++ IIYRDLKPENL++ + GY+KL DFGFAK++  G++TWTFCGTPEYV+PEIILNK H  + D+W++GIL +ELLTG+PPFTG+D M  YT ILKG+E  D    ++I+ R    I+ LCK N +ERLGN   G+ +IK H++F GF W  ++ + L SP   +V   TDHS FD++  EDE+PPDE SGWD
Sbjct:   29 GPQILRMKVEELEAQLKKKDEELNAQQLQIKQLEDQLAQQNQAIADISDALRNKCFQLTKLQEALKNQGDLELLSSPTKTKFSQRLSGLLRETLNKRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEV--------------------------VKVTQSTKDHEEPQVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELVKVKNEN-VTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDF--PKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWD 738          

Query: 1964 LELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++++ TLGVGGFGRV+LV+L  D   T+ALKC+KK  +V+++QQ+HV SEK+IL EC   FI R Y TF+D KFV++LME CLGGELW+ LRD   F ++  +FC+ CV+EA  YLH+RGI+YRDLKPENLL+   GY+K+ DFGFAK++  G++ WTFCGTPEYV PE+I+N+ HD  +D W++G+L YELL G PPF+G DPMK Y  IL G+E    F N  +  RA   I+ LC+ N +ERLGN   G+ +++ HK+FQGFDWES+R   L SP   +V+  TD  NFD F ++ ++PPDE SGWD +
Sbjct:   34 MDVIATLGVGGFGRVQLVKLK-DSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVRFYRTFRDQKFVFLLMEACLGGELWSVLRDSGGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVH-FPN-EVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHD 342          

Query: 1973 VCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            + TLGVGGFGRV+LV+L  D   T+ALKC+KK  +V+++QQ+HV SEK+IL EC   FI R                   GG           F ++  +FC+ CV+EA  YLH+RGI+YRDLKPENLL+   GY+K+ DFGFAK++  G++ WTFCGTPEYV PE+I+N+ HD  +D W++G+L YELL G PPF+G DPMK Y  IL G+E    F N  +  RA   I+ LC+ N +ERLGN   G+ +++ HK+FQGFDWES+R   L SP   +V+  TD  NFD F ++ ++PPDE SGWD +
Sbjct:    1 IATLGVGGFGRVQLVKLK-DSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVR-------------------GG-----------FQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVH-FPN-EVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHD 276          

Query: 2048 ALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDED 2860
            +LK  K+  +V+ KQ +H ++EK+IL      F+ RL  +FKD   +YM++E   GGE+++ LR    F +  ++F    ++ AF+YLHS  +IYRDLKPENLLI   GY+++ DFGFAKR  +  RTWT CGTPEY++PEIIL+K ++   D+W++G+L YE+  G PPF  + P++IY  I+ G     +      +      ++ L + +  +R GN   G+ +IK+HK+F   DW +I ++ + +PF PK     D SNFDD+++E+
Sbjct:    8 SLKATKRTKVVKLKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG----KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFDDYEEEE 272          

Query: 1919 NDAEMEKL-----VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLE-CRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKR-IGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRAS-SFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFD 2842
            NDA+   L     +  K  D + +  LG G FG+V L +   D    YA+K MKK  I+Q K++ H+++E+ +L++  R  F+  L+ +F+    +Y +M+   GGEL+  L+ +  F +   +F    +  A  YLHS  I+YRDLKPEN+L+   G++ L DFG  K  I     T TFCGTPEY++PE++    +D T D+W +G + YE+L G PPF   +  ++Y  IL           R  T  A+ S ++ L   +  +RLG     + EIK+H +F   +W  +  + + SP++P V+   D  NFD
Sbjct:   72 NDADHINLGPSANLQAKPSDFDFLTVLGKGSFGKVLLAKHKSD-GIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILH-----QPLQLRPCTTNAAISVLEGLLHKDPHQRLG-ATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFD 380          

Query: 1949 VKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHS-RGIIYRDLKPENLLITTSGYLKLCDFGFAKR-IGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDD---FQDEDELPPDEY 2881
            V + + + +  LG G FG+V LVR     Q  YA+K +KK  IV   +  H ++E ++L   +  F+  L  +F+    +  +ME   GGEL+  L  +  F +  T+F    ++ A DYLH+ + ++YRDLK ENL++   G++K+ DFG  K  I  G    TFCGTPEY++PE++ +  +    D+W +G++ YE++ G  PF   D  K++ LIL      DI   R ++  A + +  L K +  +RLG G    +EI  H +F G  W+ +  + +  PF P+V S TD   FD+    Q     PPD +
Sbjct:  145 VTMNNFDYLKLLGKGTFGKVILVREKATGQY-YAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL----MEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITPPDRF 455          

Query: 1955 LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKG-IEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSST-DHSNFDDFQDE 2857
            L D +++ TLG G FGRV LVR  H+ +  YA+K +KK  +V+ KQ +H   E+++L      F+ R++ TF+D + ++M+M+   GGEL++ LR    F + + KF    V+ A +YLH+  IIYRDLKPEN+L+  +G++K+ DFGFAK +     TWT CGTP+Y++PE+I  K ++ + D+WS+G+L YE+L G  PF    PMK Y  IL+G +     FH   +       +  L   +   R+GN   G  +IK+H +F    WE +  +D+ +P+ P +TS   D S FD + +E
Sbjct:   67 LHDFQIMRTLGTGSFGRVHLVRSVHNGRY-YAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQT--VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVV-----DLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYPEE 361          

Query: 1955 LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKG-IEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSST-DHSNFDDFQDED 2860
            L D +++ TLG G FGRV L+R +H+ +  YALK +KK+ IV+ KQ +H   E+++L      FI R++ TF+D + V+M+M+   GGEL++ LR    F + + KF    V  A +YLHS+ IIYRDLKPEN+L+  +G++K+ DFGFAK   +   T+T CGTP+Y++PE++  K ++ + D+WS G+L YE+L G  PF  ++ MK Y  IL   ++    FH       A   ++ L   + +ERLGN   G E++K+H +F    WE +  + + +P+ P +     D S FD + +E+
Sbjct:   85 LSDFQILRTLGTGSFGRVHLIRSNHNGR-FYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHP-----DAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEE 380          

Query: 1955 LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSST-DHSNFDDFQDED 2860
            L+D +++ TLG G FGRV L+R  H+ +  YA+K +KK  +V+ KQ +H   E+ +L      FI R++ TF+D + ++M+M+   GGEL++ LR    F + + KF    V  A +YLHS+ IIYRDLKPEN+L+  +G++K+ DFGFAK   +   T+T CGTP+Y++PE++  K ++ + D+WS GIL YE+L G  PF  ++ MK Y  IL        F N  +       +  L   + ++RLGN   G E++K+H +F+   WE +  +++ +P+ P +     D S FD + +ED
Sbjct:   84 LQDFQILRTLGTGSFGRVHLIRSRHNGR-YYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDV----KDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEED 379          

Query: 1949 VKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAK-RIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILK-GIEATDIFHNRRITFRASSFIQALCKFNAAERLG-NGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDD 2845
            + + D +L+  +G G FG+V  VR   D Q  YALK ++K +IV   +  H ++E+ +L      FI  L  +F+  + +Y ++    GGEL+  L+ +  FD    +F    +L A D LH   ++YRDLKPEN+L+   G++ LCDFG  K  +    +T TFCGTPEY++PE++L   +    D+W++G+L YE+LTG PP+   D  K+Y  IL+  +   D F        A   +  L   +   RLG NGA   +EI++H +F    W+ +  +  + P+ P V++S D SNFD+
Sbjct:  342 LSIDDFDLLKVIGKGSFGKVMQVR-KKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDR-----DAKDLLIGLLSRDPTRRLGYNGA---DEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDE 634          

Query: 1913 ICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAK-RIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFD 2842
            I  D +  K   + + D +L+  +G G FG+V  VR   D Q  YALK ++K +IV   +  H ++E+ +L      FI  L  +F+  + +Y+++    GGEL+  L+ +  F    ++F +  +L A D LH   +IYRDLKPEN+L+   G++ LCDFG  K  +    +T TFCGTPEY++PEI+L + +  T D+W++GIL YE++TG PP+   +   +Y  IL+      +         A   +  L   + + RL  G  G +EI++H +F+   W+ +  +  + P+ P V S  D +NFD
Sbjct:  327 ITVDYKPSKNKPLSIDDFDLLKVIGKGSFGKVMQVR-KKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQ----QPLLFPDGFDPAAKDLLIGLLSRDPSRRL--GVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFD 630          

Query:  908 QEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQ----TNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYD--GEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            ++EL  K+  I  L+ E++K  SVL     +             + R+++QG+S E    +    ++  L ++ K++  K L++E+IL N  L NL   QV E++E M ER   R  Y+I E E G HLYV E G  +V K   +L ++   + FGELA+LYNC RTASV+A T  KLW +DR+ FQ IMM+TG+ R  E + FL+SV LLK L E  L K+ +++E   +EEGE IIRQG   D FFII+SG+V +TQR +   +   +R L+ G YFGEKAL   + RTAN  A       L L R+ F++ IG+L++++   Y+D +  +   ++       A+ ++  NV+L+DL +V TLG+GGFGRVELV+++ D + T+ALK +KK+HIV+T+QQDH++SEKKI++E  S FI RL+ TFKD K++YML+EVCLGGELWT LRD+  FDD  T+F +GCV+EAF YLHS+GI+YRDLKPENLL+   GY KL DFGFAK+IG G++TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL YELLTG+PPF+G DPMK Y +ILKGI+  D    R+IT  A + I+ LC+ N  ERLG   GGL++I  HK+F GF+W+ +R + L SP  PK+ S  D SNFDD+  +D++PPD+ +GWD++
Sbjct:    4 EQELRRKDELIRRLESELDKYRSVLQPPASA-------GPGGRSRARNQRQGISAEPQSAKQVADSSKPLQRHPKNSRSKELIKEAILDNDFLKNLEASQVREVVECMCERMFKRDEYIIKEKEPGSHLYVLEEGKCQVTKEGTVLGHMGPGKAFGELAILYNCTRTASVRAQTSGKLWAIDRQTFQTIMMKTGLMRTAEHMEFLRSVNLLKDLAESYLLKIADVIEETFYEEGEYIIRQGARGDTFFIIKSGNVDITQRTNVHSDPVHVRNLSKGAYFGEKALKGEDLRTANCIAGKGGVTCLVLDREAFVQFIGNLDDIQRDQYDDSQRGVDPQTASHL---RAQQDEFANVRLEDLTVVKTLGIGGFGRVELVQVAGD-KRTFALKTLKKHHIVETRQQDHIMSEKKIMMESNSPFIVRLHKTFKDKKYLYMLLEVCLGGELWTILRDRGSFDDSTTRFYVGCVIEAFQYLHSKGIVYRDLKPENLLLDGHGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFSGTDPMKTYNIILKGIDMIDF--PRKITRNAHALIKKLCRDNPVERLGYQKGGLKDIMKHKWFDGFNWDGLRSRKLNSPIAPKIKSPVDASNFDDYPADDDIPPDDMTGWDKD 660          

Query: 1046 RSKKQGVSGESN-----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGE--EQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKY-FQGFDWESIRKQDL------------------VSPFH--PKVTSSTDHSNFDDFQDEDELPPDEYSGWDE 2896
            + K+Q VSGES+     + +T  +L ++ K    K L++++I +N  L NL   QV E+++ MY     R   +I EG+ G+ LY    G  +V +  ++L  +     FGELA+LYNCRRTA+V A+   KLW +DR VFQ IMMRTG+ RQ E + FLKSVPLLK LP  +L+KL ++LE+  +  G+ IIR+ E  D F+II  GS +VTQR +G+   + IR L  G+YFGEKALLS + RTANV A  +  + L + R  F+ +IG+++EL+ K+Y DEK    ++            E   ++ L+DLE+V TLG GGFGRVELV        TYALKC+KK HI+ T+QQ+HV SEK+IL+E  S FIC++Y TFKD K+VYML+E CLGGELWT LRD+  F+D   +FC+ CV+E F+YLHS+GI+YRDLKPENLL+   GY+KL DFGFAK+IG G++TWTFCGTPEYV+PEIILNK HD +SDYWS+GIL +ELLTG+PPF+ +DPMK Y +IL+G++  +    +RI     + I+ LCK N  ERLG    GL +IK HKY    F      ++D                    SP +   +V SSTD+SNFD +  + ++PPDE SGWDE
Sbjct:   19 KEKRQAVSGESSTKAQEESRTGKELERFPKDFRSKQLIKDAIFENDFLKNLEAAQVREIVDCMYSNTFQRNDVIIQEGDAGNALYAIADGRLQVTRENKVLGEMVAGMVFGELAILYNCRRTATVTAMEPTKLWKIDRRVFQIIMMRTGMIRQAEHMAFLKSVPLLKELPNAELSKLADVLEVDFYHAGDYIIRENERGDTFYIITKGSARVTQRIEGQTGPKEIRKLQKGDYFGEKALLSEDRRTANVIAEENGVECLVVDRTVFMTVIGNMDELREKDYGDEKRGAKRTLDVPEEERKVSKE-FADLTLEDLEVVATLGTGGFGRVELV--------TYALKCLKKKHILDTRQQEHVYSEKRILMETNSPFICKIYRTFKDRKYVYMLLEACLGGELWTILRDRGTFEDATARFCIACVVEGFEYLHSKGIVYRDLKPENLLLDAKGYVKLVDFGFAKKIGSGRKTWTFCGTPEYVAPEIILNKGHDLSSDYWSLGILIFELLTGSPPFSSSDPMKTYNIILRGLDMVEF--PKRIGRNPQNLIKRLCKDNPVERLGYQKDGLSDIKKHKYVVPWFPLAGTHRRDPRTSNQTRFWLMTTTLSFKTSPIYLLIRVESSTDYSNFDVYSKDMDIPPDEMSGWDE 652          

Query: 1955 LKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKG-IEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDED 2860
            L+D EL  TLG G FGRV L R        YALK M    +++ KQ +HV +EK IL+     FI  L  T  D  F+YML+E   GGEL+T LR    F++    F    ++ A DYLH   I+YRDLKPEN+L+   G++KL DFGFAK   +  +TWT CGTPEY++PEII +K H+   D+W++GIL YE+L G PPF  ++P  IY  IL G +E      N      A   I+ L   +   RLG+   G E++K+HK+F+  DW  + ++ L  P +PK++   D  NFDD+ +ED
Sbjct:   15 LQDFELSKTLGTGTFGRVLLAR-DRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKE--VHDKTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKILSGKVEWPKHMDNT----SAKDLIKKLLVHDRTRRLGSMKNGSEDVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNFDDYPEED 310          

Query: 1964 LELVCTLGVGGFGRVELVR--LSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFD-DF-----QDEDELPP 2872
             EL+  LG G FG+V LVR  +  D  + YA+K +KK   ++ + +   + E+ IL++ +  FI RL   F+    VY++++   GG+L+T L  +I F +   KF L  +  A D+LH  GIIYRDLKPEN+L+  SG++ L DFG +K     ++T++FCGT EY++PE++  + H   +D+WS G+L +E+LTG+ PF G D      +ILK       F    +T  A S ++ L K N   RLG G  G+E+IK H +F   +WE + K+++  PF P    + D   FD +F     QD   +PP
Sbjct:    9 FELLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKK-ATLKVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQF----LTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPP 314          

Query: 2147 ICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLG---------CVLEAFDYLHSRGIIYRDLKPENLLIT----TSGYLKLCDFGFAKRI-GIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGI 2608
            I  L + ++  K VY++ME+  GGEL          D I+   CL           +     +LH  G+++RDLKP N++      T   L++ DFGFAK++        T C T  +V+PE++  + +D   D WS+G+L Y +L+G  PF    P    ++ILK I
Sbjct:  410 IVHLRDAYEAGKQVYIVMELMRGGEL---------LDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFAVG-PEDTPSVILKRI 567          

Query: 1949 VKLKDLELVCTLGVGGFGRVELVRLSHDH--QSTYALKCMKKYHIVQT-KQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCL-RDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKR-IGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFD 2842
            V  +  EL+  LG GG+G+V LV+ +H H  +  +A+K +KK  I+++ K   H  +E+ IL   +  FI  L   F+    +Y+++E   GGEL+  L R+ I  +D    F L  +  A ++LH +GI+YRDLKPEN+L+  +G++KL DFG  K  I     T TFCGT EY++PEI+    H    D+WS+G L Y++LTGTPPF  ++  K    ILKG     +     +T  A  FI+ L K +   RLG  AG    IK+H +F+   WE +  + +  PF P ++   D S FD
Sbjct:   60 VGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTAC-FYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKG----KLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFD 357          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR--YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDF-QDEDELPPDEYSGWD 2893
            +IE L  +  L  E   EL++K+  I+ LQ E++K  SV+      +   + +      Q R+K+Q +S E      +D +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP    L E  L+KL ++LE   +  GE IIRQG   D FFII  G V VT+    +GE   +R+L  G++FGEKAL   + RTA+V A  +VT  L + R  F  LIG L ++ +K ++D                +AE     ++ L D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL +ELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A + I+ LC+ N  ERLGN   G+++I+ HK+F+GF+WE ++K  L  P  P VTS  D SNFD F +D ++ PPD+ SGWD
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNELHE----QQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY---------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDDNSGWD 681          

Query:  893 QLKLTQEELNEKNIRIEELQREINKLTSV-LDQTQISLESNDMISSVNS---------IQNRSK-KQGVSGESNKDQTNLKLIKYK-----------KSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKN--KNY------EDEKHXXXXXXXXXXICNDAEMEKL--------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            QL+  Q+EL  K  +IE+LQ  I+   +V L  T +   S    S++N          +  R + K+GVS E      +  L +Y+           K++  K L+ E+IL N  L  L    + EM++ MYE+    G  VI EG+ G++LYV   G  EV +  +LL  +     FGELA+LYNC+RTA+VKA+  + +W L+R+ FQ IMM+T   R +E   FL+SV LLK LPE KL ++V+ LE++  E+GE IIR+GE  + FFII  G V VTQ  +G  + Q I+TL +G+YFGE+AL+S + R+AN+  N + T  L + R  F +++G   EL+   K Y       DE+      S +       E+ +L         N   ++LE++ TLG+GGFGRVELV+L  D +ST+ALKC+KK H+V T+QQ H+ SEKKIL +  S FI RL+ TF+D K++YML+EVCLGGELWT LRD   F++   +FC+GCVLEAFDYLHS GIIYRDLKPENLL+   GY+K+ DFGFAK+IGIG++TWTFCGTPEYV+PE+I+NK HDF +D WS+GIL +ELLTG PPF+G+DP+KIYT++L GI+  D    +RI  R    I+ LCK N  ER+GN   G+ +IK HK+FQGF+WE ++ + L SP   ++    DHSNFD F    E  PDE SGWD++
Sbjct:   64 QLRRLQKELETKVSQIEKLQDAIHSHQTVGLSPTALCHHSCRHFSAINQGRFHKVAVEVHRRLRAKEGVSAEP--PSADNFLWRYRPSSVSTARTVHKNSDTKRLINEAILSNDFLKKLEPQHMREMVDCMYEKVYSEGQLVIQEGDAGNYLYVLAEGLLEVIQNGKLLGEMHPGTAFGELAILYNCKRTATVKAVLQSHIWTLERQTFQTIMMQTTQARHQEYFTFLRSVSLLKQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIAKGQVTVTQSSEGFTQPQEIKTLGVGDYFGERALISEDVRSANIICNENDTQCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDERRHFLPHSQQSDSPEAQELSRLRERTARIPANQPFQELEVIATLGMGGFGRVELVKLK-DEESTFALKCIKKKHVVDTRQQQHIYSEKKILQQTNSSFIIRLFRTFRDNKYIYMLLEVCLGGELWTVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAKQIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIYTMVLHGIDRVDF--PKRIGKRPDDLIRRLCKLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRGPMDHSNFDMFPPNSEEAPDELSGWDKD 767          

Query:  842 RPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQ------------------------------------NRSK--KQGVSGE---SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEE--QVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVN-----------VKLKD-------------LELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            +P  D +  + +E L  ++KL  EEL  +   I+ LQ ++ K T VL +    L +  +  ++N +Q                                    NR K  K GVS E   S+  + + +  +  K  S+K LL +++ KN  L  L   Q+ +M+E MYER   +G  VI +GE G+HL+V   G  EV++  +LL ++     FGELA+LYNC RTASV+A+   K W LDRE FQ IM RT   R E+   FL+SV LL  LP+ KL+K+V+ LE++ +++GE IIR+GE    F+II  G VKVTQ  +  +  Q+I  L  G+YFGEKAL+S + R+AN+ A+ +  + L + R+ F + +G+ NEL       +KHL    +S         ++K V+           ++LKD             LE++ TLGVGGFGRVELV++  +   T+ALK +KK H+V+ KQ++H+ SE++IL E RS FI RLY TFKD K+VYML+E CLGGE+W+ LRD+  FDD   KFC+GCV EAF+YLH +G++YRDLKPENLL+   GY+KL DFGFAK+I  G++TWTFCGTPEYV+PEIILNK H+F+ D+W++GIL +ELLTG+PPF+G+D M IYT ILKGIE  D    + I+ R    I+ LC+ N +ERLGN   G+ +IK H++F GF+WE ++ + L SP   ++    DHS FD +  +++ PPDE SGWDE+
Sbjct:   29 QPTRDSL-RVRVEELEREVKLKDEELGAREQHIKALQEQLAKQTQVLSELSEELHAKSI--TLNMLQDAMRSEPSTGLAFRPASVRASGKSSPNLSVRTKDTPNRRKGAKSGVSAEPTSSSLQKFSFEKARVPKDASVKKLLTDALNKNQYLRRLELQQIKDMVECMYERNYQQGECVIKQGEPGNHLFVLAEGKLEVFQHNKLLTWITVWTTFGELAILYNCTRTASVRAVNKVKTWALDREAFQNIMRRTAETRHEQYRNFLRSVSLLANLPDDKLSKIVDCLEVEYYDKGEYIIREGEEGSTFYIIAQGKVKVTQTTEAHKLPQIINALQKGDYFGEKALVSDDVRSANIIADDNGVECLVIDRETFDQTVGNFNEL-------QKHLQGYVASLDRDDKKRHLKKSVSRHQSQSLSPGFMQLKDMVSLFTSSRPFHHLEVIATLGVGGFGRVELVKVKGE-DVTFALKAIKKKHVVENKQEEHIHSERRILAEARSPFIVRLYRTFKDSKYVYMLLEACLGGEVWSLLRDRGSFDDPTAKFCIGCVTEAFEYLHRKGVLYRDLKPENLLLDMEGYVKLVDFGFAKKIRSGQKTWTFCGTPEYVAPEIILNKGHNFSVDFWALGILVFELLTGSPPFSGSDQMTIYTFILKGIEKMDF--PKMISKRPEDLIRKLCRRNPSERLGNLKNGITDIKKHRWFTGFNWEGLKARTLASPLKRELKGPMDHSYFDSYPPDEDSPPDELSGWDED 768          

Query:  872 EIENLHNQLKLTQE---ELNEKNIRIEELQREINKLTSVLD-QTQISLESNDMISSVNSIQNRSKKQGVSGESN----KDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR--YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVT 2815
            +IE L  +  L  E   EL++K+  I+ LQ E++K  SV+   TQ   + N++       Q R+K+Q +S E      +D +++ L  Y KS   K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP    L E  L+KL ++LE   +  GE IIRQG   D FFII  G V VT+    +GE   +R+L  G++FGEKAL   + RTA+V A  +VT  L + R  F  LIG L ++ +K ++D                +AE     ++ L D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL +ELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A + I+ LC+ N  ERLGN   G+++I+ HK+F+GF+WE ++K  L  P  P V+
Sbjct:   14 KIEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNELHE-----QQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY---------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 654          

Query:  908 QEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKK-QGVSGE--SNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR--YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVT 2815
            +  L ++   I+EL+R+++K  SVL   Q+             I  R+++ QG+S E  +++D +   L +Y KS+  K L++E+IL N  + NL   Q+ E+++ MY  +  +   +I EG+ G  +YV E G  EV K    LC +   + FGELA+LYNC RTA+VK LT+ KLW +DR+ FQ IMMRTG+ +  E + FLKSVP    L E  L+KL ++LE   +  GE IIRQG   D FFII  G V VT+    +GE   +R+L  G++FGEKAL   + RTA+V A  +VT  L + R  F  LIG L ++ +K ++D                +AE     ++ L D  ++ TLGVGGFGRVELV+L  D   T+A+K +KK HIV T+QQ+H+ SEK I+ E  S FI RLY TFKD K++YMLME CLGGELWT LRD+  F+D  T+F   CV+EAF YLHS+GIIYRDLKPENL++   GY KL DFGFAK+IG GK+TWTFCGTPEYV+PEIILNK HD ++DYWS+GIL +ELLTG+PPF+G DPMK Y +IL+GI+  +    ++IT  A + I+ LC+ N  ERLGN   G+++I+ HK+F+GF+WE ++K  L  P  P V+
Sbjct:   23 ERRLADREDEIQELKRKLHKCQSVLPSAQL-------------IGPRTRRAQGISAEPQTHQDLSRQALRRYPKSDWSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY---------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 638          

Query:  314 MSHGLYQSAVSNKSSDNDPFFHVVERFAIREASDNLSRSMGXXXXXXXXXXXXAHSRNESFNTTDIQTITESINHHGXXXXXXXXXXXXXAVSYSGNECGLSNNNKYQLFIDENNQPVTPSYRFSCSCWKDFAENKSSIYRGFHSEPSLNFPPAMGPYHSKHIESCFKHKEISSVLRPIGDEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            MSHGLYQSAVSNKSSDNDPFFHVVERFAIREASDNLSRSMGSNLVNQSSNNSSAHSRNESFNTTDIQTITESINHHGNLLQNQVQLNLDNAVSYSGNECGLSNNNKYQLFIDENNQPVTPSYRFSCSCWKDFAENKSSIYRGFHSEPSLNFPPAMGPYHSKHIESCFKHKEISSVLRPIGDEIYEMEIENL NQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHLLSKSSSKVSICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE
Sbjct:    1 MSHGLYQSAVSNKSSDNDPFFHVVERFAIREASDNLSRSMGSNLVNQSSNNSSAHSRNESFNTTDIQTITESINHHGNLLQNQVQLNLDNAVSYSGNECGLSNNNKYQLFIDENNQPVTPSYRFSCSCWKDFAENKSSIYRGFHSEPSLNFPPAMGPYHSKHIESCFKHKEISSVLRPIGDEIYEMEIENLRNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHLLSKSSSKVSICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 862          

Query:  854 DEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            + +  +E E   + L+  + E++EKN++IEELQREI+KL SVLDQT   L  +   SS+N I+ RSK+ G+SGES+  Q    L K+ KSN +K ++R++I+ N LL+ L   QV+E+IE MYE+     CYVI EGEEG+ LYVA+ G+FEV+K E+L+  +   +CFGELALLYNC+RTASVKAL    LWVLDR +FQ IMM+TG++RQ++L  FL+SV L + L E KL K+VEL+E+Q + +G+CIIRQGE AD FFII++G VKVTQ+ +G+E  +R ++ GEYFGEKALL    RTAN+YA    T+VLCLYR+ F ELIG+LN L+ K Y+DE       S       ++   K  +  L D E+V TLG GGFGRVELV  S D   +YALK MKK +IVQTKQQDHV+SEKKILLEC+S +ICRLY TF D K+VY+L EVCLGGELW  LRD+IHFDD IT FCL CVLEA  YLHSRGI+YRDLKPENLL+  SGYLKLCDFGFAK+IGIG RTWTFCGTPEYV+PEIILNKSHDF+ D+WS+GILTYELL G PPF  NDPMKIY + LKGIE ++I HN +IT +A+S IQ LC++   ERLGNG  G+EEI+ HKYFQGFDWE ++   + SPF+PK+    D SNFD F +E ++PPDE SGWD++
Sbjct:   34 NSVSNVEAEKHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTHSDLSFDHDSSSLNDIKARSKRLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCYVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGELNVLQAKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITSFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPIDTSNFDKFTNESDIPPDENSGWDKD 715          

Query:  896 LKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQ-TNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGE-----EQVIRTLTMGEYFGEKALLSAETRTANVYA-NSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKL------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            +K  ++ L +K+ +I EL  +++K  SV   TQ   + N++ S  ++ Q R +  G+S E    +  N +   ++K +  K L++ SIL+N  + NL   Q+  +++ M   +      +I EGE G  +YV E G   V K    L  +     FGELA+LYNC RTA+V A+TD KLW +DR  FQ+IMMRTG+ + EE L FLKSVP+ K L E  L K+  +LE   +  G+ IIRQG   D FFII SG V+VT++   +     EQ IR +  GE+FGEKAL   + RTAN+ A + +  D L L R+ +++LIGDL  L+ + YED               ND+  E L       N+ LKDL ++ TLG+GGFGRVELV++  + + TYALK +KK+HIV+T+QQ+H+++E+ IL   +S FI RL+ TFKD KF+YMLMEVCLGGELW+ LRD+  FD+  TKF   CV+EA  YLHSRGI+YRDLKPENLL+   G+ K+ DFGFAK+IG G++TWTFCGTPEYV+PEIILNK HD  +D WS+GIL +ELLTG PPFT  DPMKIY +ILKGI+A +    ++I+  A + I+ LC+ N  ER+G G GG++E + H + + F+W+ +    +  P  P++ S TD SNFD++  E E+PPD+ SGWD +
Sbjct:   19 VKKLEKLLQQKDEKIAELTSQLDKYQSVFSATQ---KQNNVQSGPHNNQTRVRGLGISAEPQTAKIANFQPSFFQKDSKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDG-------------VNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEF--PKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRD 680          

Query:  908 QEELNEKNIRIEELQREINKLTSVLD-----QTQIS---------------LESNDMISS---VNSIQN-----------------------------------RSKKQGVSGESNKDQTNLKLIKY-KKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGE-----EQVIRTLTMGEYFGEKALLSAETRTANVYA-NSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKL------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            +EEL++K++ IE LQR+++K  S+L      + QIS               +  +  IS+   +NS QN                                   R K+  +SGES    ++ +++ Y +K    K L++ SIL+N  + NL   Q+  +++ M   +      +I EGE G  +YV E G   V K    L  +     FGELA+LYNC RTA+V A+TD KLW +DR  FQ+IMMRTG+ + EE L FLKSVP+ K L E  L K+  +LE   +  G+ IIRQG   D FFII SG V+VT++   +     EQ IR +  GE+FGEKAL   + RTAN+ A + +  D L L R+ +++LIGDL  L+ + YED               ND+  E L       N+ LKDL ++ TLG+GGFGRVELV++  + + TYALK +KK+HIV+T+QQ+H+++E+ IL   +S FI RL+ TFKD KF+YMLMEVCLGGELW+ LRD+  FD+  TKF   CV+EA  YLHSRGI+YRDLKPENLL+   G+ K+ DFGFAK+IG G++TWTFCGTPEYV+PEIILNK HD  +D WS+GIL +ELLTG PPFT  DPMKIY +ILKGI+A +    ++I+  A + I+ LC+ N  ER+G G GG++E + H + + F+W+ +    +  P  P++ S TD SNFD++  E E+PPD+ SGWD +
Sbjct:   75 EEELDQKDLLIENLQRQLDKYRSILQSPMQIKPQISSIYNEDFQLFTPNGDVSHDSSISTGEMLNSSQNNQVLCYNCGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDG-------------VNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEF--PKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRD 793          

Query:  854 DEIYEMEIENLHNQLKLTQEELNEKNIRIEELQREIN-------KLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESI--LKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDG--EEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHXXXXXXXXXXICNDAEMEKLVN----VKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEE 2899
            + +   EIE LH ++        EK+ RI +L  E+N       K+ SVL Q    +E N +  S +++  RSKKQ V GES    +++++  ++KS S   L+  +I   ++  L  L   Q+ ++ + MY + +    Y+I EGE G H+YV  SG  EV K  + L  +     FGELA+L NC RTASVKA+T+A  W ++R+V+QAI+ ++ +Q+ EE  +FL+SV L K L + +L K+V+ L ++ +  GE I+++GE    F+II++G VKV Q   G  E Q IRTLT G+YFGE+ALL  E RTA+V A+S   +VL L R+ F+ LIG   EL +K YED K    +SS+        +   + N    ++  DLE++ TLGVGGFG+VELVR  +DH   +ALK + K +IV+ KQ++H+ISE+KILLE +  FIC LY TF+D K+VY+LME CLGGE+WT LR+K  FDD +TKF LG  + A  YLHS+ IIYRDLKPEN++    G++KLCDFGFAK IG G++T+TFCGTPEYV+PEIILNK HD + D W++GIL +ELLTG+PPF G++PM +Y  ILKG+E  +    R+I   A   I+ LCK N  ERLG G  G+  I +HKYF GF+WE++  +++     PK+ ++ D   FD F +++ +P DE SGWD+E
Sbjct:   92 NNVLSQEIEELHKRI-------TEKDFRIRQLTHEVNDLRQNYDKVKSVLYQKSQVVEDNTLHRSESNL--RSKKQVVYGESF-SLSSIEMKIHEKSESATLLIEMAIKSCQDDFLKKLEQQQIKQICQCMYSKTVKANVYIIQEGEPGYHMYVLASGKMEVIKDGKKLRDMYPGELFGELAVLQNCLRTASVKAVTEASFWTIERKVYQAILQKSNMQQSEEYKKFLQSVNLFKSLSKDELTKIVDALLMEEYSLGEYIVQEGEEGQTFYIIKNGKVKVVQNVQGVVEPQEIRTLTTGDYFGERALLKEEIRTASVIADSDNVEVLLLDREDFIRLIGQNYELNSKEYEDYKIKKQQSSTIPIESTKKDNIIIKNKYQIIQKNDLEVISTLGVGGFGKVELVRHKNDHSMVFALKSLSKQYIVELKQEEHIISERKILLEIKFPFICELYKTFRDNKYVYLLMEACLGGEIWTHLRNKTVFDDRMTKFILGSSILAIQYLHSKNIIYRDLKPENMVFDNRGFVKLCDFGFAKLIGNGRKTFTFCGTPEYVAPEIILNKGHDASVDIWAIGILAFELLTGSPPFVGDEPMIVYNKILKGVEKVEF--GRKINRTAVQLIKMLCKDNPTERLGYGKDGISAIMNHKYFTGFNWEALLSKEMTPVIIPKLENNIDTHYFDQFTEKNFVPLDETSGWDDE 776