Acid sphingomyelinase-like phosphodiesterase

Overview
NameAcid sphingomyelinase-like phosphodiesterase
Smed IDSMED30000819
Length (bp)1598
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Acid sphingomyelinase-like phosphodiesterase (SMED30000819) t-SNE clustered cells

Violin plots show distribution of expression levels for Acid sphingomyelinase-like phosphodiesterase (SMED30000819) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Acid sphingomyelinase-like phosphodiesterase (SMED30000819) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Acid sphingomyelinase-like phosphodiesterase (SMED30000819) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000819

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30000819h1SMcG0007429 dd_Smed_v4_5377_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30000819h1SMcG0007429 dd_Smed_v4_5377_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000819h1SMcG0007429 dd_Smed_v4_5377_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30000819h1SMcG0007429 dd_Smed_v4_5377_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30000819h1SMcG0007429 dd_Smed_v4_5377_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 168.318 bits (425), Expect = 8.672e-46
Identity = 127/440 (28.86%), Postives = 202/440 (45.91%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLN----ISNLNYSL------------ENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWS-TTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            M  L W+   A +       G FW I DLHL+    +S   + +               G+Y  DS   L+ S++  MK I   P+FI+  GD+  H      G+A   E +  ++  I  +F    V  +LGNHD  P+N    +    N  YN    +W+ +L+N     I   KKG FY   +   +G   +VVLNT L+YT N LT +  DP  QF+WLE  +  A      +++VGH+PPG  E +          FN + + +++ ++  I    F H H+D+F+++Y+    P+  +F+ P VTP++ +  G V    NP+ R++++   T        Y   L  +N +    W  EY   E   VP  SA  +  +L   A   ST   +++ Y+     +    C  D  C  Q +C+M+ VD  A+ +C
Sbjct:    1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKN---QFPAGSNNIYNQIAELWKPWLSN---ESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQ-NKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQST-LQRYYVYNSVS--YSAGVC--DEACSMQHVCAMRQVDIDAYTTC 428
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 143.665 bits (361), Expect = 1.624e-37
Identity = 100/335 (29.85%), Postives = 161/335 (48.06%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLN----ISNLNYSL------------ENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWS 1114
            M  L W+   A +       G FW I DLHL+    +S   + +               G+Y  DS   L+ S++  MK I   P+FI+  GD+  H      G+A   E +  ++  I  +F    V  +LGNHD  P+N    +    N  YN    +W+ +L+N     I   KKG FY   +   +G   +VVLNT L+YT N LT +  DP  QF+WLE  +  A      +++VGH+PPG  E +          FN + + +++ ++  I    F H H+D+F+++Y+    P+  +F+ P VTP++ +  G V    NP+ R++++ 
Sbjct:    1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKN---QFPAGSNNIYNQIAELWKPWLSN---ESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA-WFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYD 328
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3B (sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol;Acc:HGNC:21416])

HSP 1 Score: 134.806 bits (338), Expect = 4.260e-34
Identity = 113/431 (26.22%), Postives = 180/431 (41.76%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLN----ISNLNYSL------------ENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH-GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWS-TTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            M  L W+   A +       G FW I DLHL+    +S   + +               G+Y  DS   L+ S++  MK I   P+FI+  GD+  H  D K  E  V+   EI    +  I        ++ P                                   G FY   +   +G   +VVLNT L+YT N LT +  DP  QF+WLE  +  A      +++VGH+PPG  E +          FN + + +++ ++  I    F H H+D+F+++Y+    P+  +F+ P VTP++ +  G V    NP+ R++++   T        Y   L  +N +    W  EY   E   VP  SA  +  +L   A   ST   +++ Y+     +    C  D  C  Q +C+M+ VD  A+ +C
Sbjct:    1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVL---EIVERLTKLI-------REVFP-----------------------------------GAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQ-NKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQST-LQRYYVYNSVS--YSAGVC--DEACSMQHVCAMRQVDIDAYTTC 380
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389])

HSP 1 Score: 129.798 bits (325), Expect = 4.799e-32
Identity = 117/418 (27.99%), Postives = 197/418 (47.13%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH-------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWC-NVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTA-ENSSYDQYHAILPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQ 1429
            G FW + DLHL+              S+   +  N    G+   DS   L+ SA   +K+      F+I  GD+  H        D   N  I  ++  I ++F +  V P+LGNHD  P++ +   +    N   N+W+ +L   D   I   +KG FYS+ + + N N+ ++ LNT L+Y  N +TLN+ DP +QF+WLE  +  ++  K K++++ H+P G    SS  I  +   +N +L+DI Q   + I    + H H D+  V+ +K   PV  +F+AP+VTP + +    + NP  RL+++     +     QY+  L  +N K    W  EY  +    +  +    L  L   F   +S  F K+++Y        +++   D  C+   IC++  +D  ++  C KQ
Sbjct:   38 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVIN-VITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWL---DEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLP-SSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSY---DSSVTCDKTCKAFQICAIMNLDNISYADCLKQ 446
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Match: SMPDL3A (sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol;Acc:HGNC:17389])

HSP 1 Score: 121.324 bits (303), Expect = 6.336e-30
Identity = 94/323 (29.10%), Postives = 163/323 (50.46%), Query Frame = 2 
Query:  476 VSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNY-SPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTA-ENSSYDQYHAILPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQ 1429
            ++  I ++F +  V P+LGNHD  P++ +    S   N   N+W+ +L   D   I   +KG FYS+ + + N N+ ++ LNT L+Y  N +TLN+ DP +QF+WLE  +  ++  K K++++ H+P G    SS  I  +   +N +L+DI Q   + I    + H H D+  V+ +K   PV  +F+AP+VTP + +    + NP  RL+++     +     QY+  L  +N K    W  EY  +    +  +    L  L   F   +S  F K+++Y        +++   D  C+   IC++  +D  ++  C KQ
Sbjct:    1 MTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWL---DEEAISTLRKGGFYSQKV-TTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLP-SSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSY---DSSVTCDKTCKAFQICAIMNLDNISYADCLKQ 315
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186012:10190157:-1 gene:WBGene00014106.1 transcript:ZK856.5.3 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 137.887 bits (346), Expect = 3.288e-35
Identity = 125/449 (27.84%), Postives = 206/449 (45.88%), Query Frame = 2 
Query:  230 ALFHLTVGFQ--GYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNE----IFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTL---NQLDPNDQFKWLEQRIQYA--------KNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPF--RLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYS---SLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFF 1510
            A FHL V +   G    +C  H + +  N +L   G+Y  D+   L++ A+ E   I+ NP+ II  GDN+ H D    E ++   N+    +F+ F +  ++P+ GNHD  P N  ++ S   +++   WE +   L         KG +Y   +++       VVLNT L+Y  N+  +   N++DP DQF +LE+ +  A        +N    + +V HI PG  E  +         +N R +D+      +I   IF H H+D F ++ +     V    +AP+VTP+   L   G+ NP+FR+Y+    ++      Y   L   N+ +   +  EYS   +      I+   ++ LL D    N T F K+  Y+ +     N   P     R   +CSM+Y DYP +YSC  +Y++       I +   L  I++ +LF 
Sbjct:   27 ADFHLDVQYSINGDNKHMC--HDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESES---SLYTKTWELWKGKLGDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFE-KTPNFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVYETDAYSKIQDISTYFINLDDLNKNKSTPFVFEYSFKDAYGITGDINPTTMSALL-DKMKNNDTLFKKYIDYNTAFW---NPQMPL-GVYRGAQLCSMEYSDYPRYYSCLSKYTKSATRSLNIPL-FSLFAIIYTELFL 459
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190366:-1 gene:WBGene00014106.1 transcript:ZK856.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 137.887 bits (346), Expect = 3.288e-35
Identity = 125/449 (27.84%), Postives = 206/449 (45.88%), Query Frame = 2 
Query:  230 ALFHLTVGFQ--GYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNE----IFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTL---NQLDPNDQFKWLEQRIQYA--------KNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPF--RLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYS---SLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFF 1510
            A FHL V +   G    +C  H + +  N +L   G+Y  D+   L++ A+ E   I+ NP+ II  GDN+ H D    E ++   N+    +F+ F +  ++P+ GNHD  P N  ++ S   +++   WE +   L         KG +Y   +++       VVLNT L+Y  N+  +   N++DP DQF +LE+ +  A        +N    + +V HI PG  E  +         +N R +D+      +I   IF H H+D F ++ +     V    +AP+VTP+   L   G+ NP+FR+Y+    ++      Y   L   N+ +   +  EYS   +      I+   ++ LL D    N T F K+  Y+ +     N   P     R   +CSM+Y DYP +YSC  +Y++       I +   L  I++ +LF 
Sbjct:   27 ADFHLDVQYSINGDNKHMC--HDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESES---SLYTKTWELWKGKLGDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFE-KTPNFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVYETDAYSKIQDISTYFINLDDLNKNKSTPFVFEYSFKDAYGITGDINPTTMSALL-DKMKNNDTLFKKYIDYNTAFW---NPQMPL-GVYRGAQLCSMEYSDYPRYYSCLSKYTKSATRSLNIPL-FSLFAIIYTELFL 459
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: ZK856.5 (pep chromosome:WBcel235:V:10186023:10190131:-1 gene:WBGene00014106.1 transcript:ZK856.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK856.5)

HSP 1 Score: 137.887 bits (346), Expect = 3.288e-35
Identity = 125/449 (27.84%), Postives = 206/449 (45.88%), Query Frame = 2 
Query:  230 ALFHLTVGFQ--GYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNE----IFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTL---NQLDPNDQFKWLEQRIQYA--------KNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPF--RLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYS---SLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFF 1510
            A FHL V +   G    +C  H + +  N +L   G+Y  D+   L++ A+ E   I+ NP+ II  GDN+ H D    E ++   N+    +F+ F +  ++P+ GNHD  P N  ++ S   +++   WE +   L         KG +Y   +++       VVLNT L+Y  N+  +   N++DP DQF +LE+ +  A        +N    + +V HI PG  E  +         +N R +D+      +I   IF H H+D F ++ +     V    +AP+VTP+   L   G+ NP+FR+Y+    ++      Y   L   N+ +   +  EYS   +      I+   ++ LL D    N T F K+  Y+ +     N   P     R   +CSM+Y DYP +YSC  +Y++       I +   L  I++ +LF 
Sbjct:   27 ADFHLDVQYSINGDNKHMC--HDDGTERNTTLGEYGDYMCDAPKPLIQLAIDESARIFPNPDLIIWTGDNVAHIDGYGWEIVLDAVNQTTSLLFSRFPNQTILPTFGNHDYAPSNGFESES---SLYTKTWELWKGKLGDENKATFLKGGYYKYRLRNATA----VVLNTNLYYNANKAYVNFTNKVDPADQFAFLEKELSNAEKCPNRISENCTSIVHIVAHIGPGVFE-KTPNFTWFRDEYNERFLDLTVRYANSIGWMIFGHHHTDTFHLIKDSKENNVQLALMAPAVTPWFSDLPGAGANNPTFRVYETDAYSKIQDISTYFINLDDLNKNKSTPFVFEYSFKDAYGITGDINPTTMSALL-DKMKNNDTLFKKYIDYNTAFW---NPQMPL-GVYRGAQLCSMEYSDYPRYYSCLSKYTKSATRSLNIPL-FSLFAIIYTELFL 459
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-1 (Sphingomyelin phosphodiesterase 1 [Source:UniProtKB/Swiss-Prot;Acc:Q10916])

HSP 1 Score: 78.9518 bits (193), Expect = 2.565e-15
Identity = 86/345 (24.93%), Postives = 151/345 (43.77%), Query Frame = 2 
Query:  407 EFIIVNGDNMFHGDAKFN-----ETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN-IWEKYLNNLDPVEIENAKKGCFY--SRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVY----NKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSD-FASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMK 1390
            + +I+ GD + H D +++       +  +   + N F S  +  +LGNH+ +P N    +S     W   +++++     P   E AK       S + Q  +G  L+ +       T   L LNQ DP+    W  + +  ++    +++++ HIPPG SE     +E    N+      ++Q    TI A  F H H D F V Y    N ++KP+   + +PSVT F        NP++R+Y+     +    D   Y+A L  + E +   W K YS+ +   +  +S     K++   F S+      KF+ Y        N +   DS C+ Q +C+++
Sbjct:  227 DMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPSTPIYWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVMDGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSE----CLEGWAFNY----YRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTFEYQ-----NPAYRIYEIDPYNKFKIVDFTTYYADLEKATEDKKPVWEKLYSARQAHGMDDLSPLSWNKVIQKLFTSEKKR--EKFYQYAFR-----NFSPQCDSTCQMQLMCNLR 551
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Match: asm-1 (Sphingomyelin phosphodiesterase 1 [Source:UniProtKB/Swiss-Prot;Acc:Q10916])

HSP 1 Score: 78.9518 bits (193), Expect = 2.565e-15
Identity = 86/345 (24.93%), Postives = 151/345 (43.77%), Query Frame = 2 
Query:  407 EFIIVNGDNMFHGDAKFN-----ETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN-IWEKYLNNLDPVEIENAKKGCFY--SRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVY----NKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSD-FASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMK 1390
            + +I+ GD + H D +++       +  +   + N F S  +  +LGNH+ +P N    +S     W   +++++     P   E AK       S + Q  +G  L+ +       T   L LNQ DP+    W  + +  ++    +++++ HIPPG SE     +E    N+      ++Q    TI A  F H H D F V Y    N ++KP+   + +PSVT F        NP++R+Y+     +    D   Y+A L  + E +   W K YS+ +   +  +S     K++   F S+      KF+ Y        N +   DS C+ Q +C+++
Sbjct:  227 DMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPSTPIYWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVMDGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSE----CLEGWAFNY----YRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTFEYQ-----NPAYRIYEIDPYNKFKIVDFTTYYADLEKATEDKKPVWEKLYSARQAHGMDDLSPLSWNKVIQKLFTSEKKR--EKFYQYAFR-----NFSPQCDSTCQMQLMCNLR 551
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347598)

HSP 1 Score: 124.79 bits (312), Expect = 2.892e-30
Identity = 116/473 (24.52%), Postives = 200/473 (42.28%), Query Frame = 2 
Query:  260 GYFWDICDLHLNI---------------------SNLNYSLEN----LGNYKSDSTILLMKSALIEMKSIYS-NPEFIIVNGDNMFHG-----DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMP--RNVIQNYSPWC----------NVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPND------QFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNF----NSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWST-TAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSG--QPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQ-----YSRGVALLFKIEISLILNVI 1489
            GYFW I DLHL+                      SN N +        G+Y  DS   L++SA+  MK+    N EF++  GD + H      + K +E +  ++  +   FSS  + P LG+ D     R + + +  W             +Y+I E+  + L  V +        + R     +    + +     ++   + +++ +   D      Q+ WLE+ +  +K  +  +++VGH+PPG  E   +  +H    F    N R +D+++     I    F H HSD F+++Y+    P+  + +APS+ P +     S NP+ RLYK+ T + +   Y Q+   LP +N      W  EY+   +  +P ISA  L      F   + ++F +   YH +   + H  +ACP    C     C++  +DY  F  C ++       R  A L     S +L V+
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHEDGSGSYRRLGELWRHWLPSEALVTFDQGGYYSI-EQTKSRLRIVALNTN-----FMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDE-RHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLSWFTR---YHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVL 486
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0347599)

HSP 1 Score: 124.79 bits (312), Expect = 2.892e-30
Identity = 116/473 (24.52%), Postives = 200/473 (42.28%), Query Frame = 2 
Query:  260 GYFWDICDLHLNI---------------------SNLNYSLEN----LGNYKSDSTILLMKSALIEMKSIYS-NPEFIIVNGDNMFHG-----DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMP--RNVIQNYSPWC----------NVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPND------QFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNF----NSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWST-TAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSG--QPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQ-----YSRGVALLFKIEISLILNVI 1489
            GYFW I DLHL+                      SN N +        G+Y  DS   L++SA+  MK+    N EF++  GD + H      + K +E +  ++  +   FSS  + P LG+ D     R + + +  W             +Y+I E+  + L  V +        + R     +    + +     ++   + +++ +   D      Q+ WLE+ +  +K  +  +++VGH+PPG  E   +  +H    F    N R +D+++     I    F H HSD F+++Y+    P+  + +APS+ P +     S NP+ RLYK+ T + +   Y Q+   LP +N      W  EY+   +  +P ISA  L      F   + ++F +   YH +   + H  +ACP    C     C++  +DY  F  C ++       R  A L     S +L V+
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHEDGSGSYRRLGELWRHWLPSEALVTFDQGGYYSI-EQTKSRLRIVALNTN-----FMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDE-RHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLSWFTR---YHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVL 486
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG32052 (gene:FBgn0044328 transcript:FBtr0332818)

HSP 1 Score: 124.79 bits (312), Expect = 2.892e-30
Identity = 116/473 (24.52%), Postives = 200/473 (42.28%), Query Frame = 2 
Query:  260 GYFWDICDLHLNI---------------------SNLNYSLEN----LGNYKSDSTILLMKSALIEMKSIYS-NPEFIIVNGDNMFHG-----DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMP--RNVIQNYSPWC----------NVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPND------QFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNF----NSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWST-TAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSG--QPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQ-----YSRGVALLFKIEISLILNVI 1489
            GYFW I DLHL+                      SN N +        G+Y  DS   L++SA+  MK+    N EF++  GD + H      + K +E +  ++  +   FSS  + P LG+ D     R + + +  W             +Y+I E+  + L  V +        + R     +    + +     ++   + +++ +   D      Q+ WLE+ +  +K  +  +++VGH+PPG  E   +  +H    F    N R +D+++     I    F H HSD F+++Y+    P+  + +APS+ P +     S NP+ RLYK+ T + +   Y Q+   LP +N      W  EY+   +  +P ISA  L      F   + ++F +   YH +   + H  +ACP    C     C++  +DY  F  C ++       R  A L     S +L V+
Sbjct:   26 GYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYNCDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPVLGHEDGSGSYRRLGELWRHWLPSEALVTFDQGGYYSI-EQTKSRLRIVALNTN-----FMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVDE-RHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRLIYDAKGNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFDTGSGQVLDYTQFWLDLPLANRANEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLSWFTR---YHRANAVRYHSGSACP--GLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVL 486
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0072265)

HSP 1 Score: 65.0846 bits (157), Expect = 1.002e-10
Identity = 65/290 (22.41%), Postives = 124/290 (42.76%), Query Frame = 2 
Query:  308 NYSLENLGNY-KSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG--DAKFNETIVMVSN---EIFNIFSSAIVIPSLGNHDIMPRNVIQNYSP-----------WCNVWYNI-WEKYLNNLDPVEI-ENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNR---LTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYN--KTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLY 1105
            N +    G+Y K D+    +   L  +   + + ++I+  GD   H   +    E + ++ +   ++  +F    + P+LGNH+  P N   ++ P           W     +I W ++L    P  +    ++G FYS  ++     + + +      Y  N+   L LN  DP  + +W    +Q A+    K+ ++GHIPPG S+   +        ++     I+     T+ A  + H H D F++ Y+    N P    ++ PSV+P+       +NP +R+Y
Sbjct:  309 NAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVN---SFPPPYVNQVDISISWLYDELDIQWRRWL----PQSVTHTVRRGAFYSVLVRPGFRIISLNMN-----YCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKV--------WSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIY 573
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Match: CG3376 (gene:FBgn0034997 transcript:FBtr0343442)

HSP 1 Score: 65.0846 bits (157), Expect = 1.015e-10
Identity = 65/290 (22.41%), Postives = 124/290 (42.76%), Query Frame = 2 
Query:  308 NYSLENLGNY-KSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG--DAKFNETIVMVSN---EIFNIFSSAIVIPSLGNHDIMPRNVIQNYSP-----------WCNVWYNI-WEKYLNNLDPVEI-ENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNR---LTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYN--KTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLY 1105
            N +    G+Y K D+    +   L  +   + + ++I+  GD   H   +    E + ++ +   ++  +F    + P+LGNH+  P N   ++ P           W     +I W ++L    P  +    ++G FYS  ++     + + +      Y  N+   L LN  DP  + +W    +Q A+    K+ ++GHIPPG S+   +        ++     I+     T+ A  + H H D F++ Y+    N P    ++ PSV+P+       +NP +R+Y
Sbjct:  309 NAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVN---SFPPPYVNQVDISISWLYDELDIQWRRWL----PQSVTHTVRRGAFYSVLVRPGFRIISLNMN-----YCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKV--------WSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYY-----DLNPGYRIY 573
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132])

HSP 1 Score: 159.458 bits (402), Expect = 8.767e-43
Identity = 126/440 (28.64%), Postives = 207/440 (47.05%), Query Frame = 2 
Query:  209 LLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLE-------------------NLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH-GDAKFNETIVM-----VSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWY----NIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWST-TAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            LL IF+  +F  +    GYFW I DLH + S   Y L                      G+Y  DS   L+ S+L  M+ I  +P+FI+  GD+  H  D +  E  V+     ++N I + F    V  ++GNHD  P+N +    P  +  Y    N+W  +L+       E  K G +Y+  + ++ G  ++V+   L +Y +N+LT    DP DQF W ++ +Q A     K++L+GH+PPG  E            FN R ++++Q +   I    F H H+D+F++ YN    P+  ++L P VTP+  +  G +    NP  R++++ T T        Y+  L  +N  +   W KEY   E   VP  S   + +++   +S+  +   K+F   L+   +D + C  D  CR   +C+++ VDY A+  C
Sbjct:    8 LLSIFI--VFGRSDALTGYFWHISDLHWDPS---YDLSSSSQSKCASSGGRPTPHAGRYGDYVCDSPWSLINSSLTAMREILPDPDFIMWTGDDTPHVPDDQLGEQAVLRIIGNLTNIIKSTFPKTKVYSAMGNHDYHPKNQM---PPAKSTIYEQTANLWRDWLHT---ASQETFKTGGYYTEKLLNQTGLRVIVLNTNL-YYDQNKLTEKVKDPADQFSWADKVLQDAAKNNEKVYLIGHVPPGLFEKKRDK-GWFRKEFNKRYIELIQKHSAVIMGQFFGHHHTDSFRMFYNSKGSPISAMYLTPGVTPWITTLPGVIDGGNNPGIRIFEYDTKTLLVKDIITYYLNLTYANIARA-RWEKEYRLTEAFRVPDASPASMHRVMERISSEKCS-LQKYFE--LNSVSYDLSECHAD--CRVDHVCALREVDYDAYEKC 428
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61])

HSP 1 Score: 123.25 bits (308), Expect = 5.705e-30
Identity = 106/365 (29.04%), Postives = 174/365 (47.67%), Query Frame = 2 
Query:  266 FWDICDLHLNIS--------NLNYSLENL--------GNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMV------SNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIG--SVNPSFRLYKWSTTAENSSYD-----QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKL 1255
            FW I DLHL+ +         + +S + +        G++  DS   L+ SA   MK +   PEFII  GD+  H   +   T V++      +  I   F    V P+LGNHD  P++    +    N  Y+    +W  +LN   P  +   +KG FYS  I+     + ++ LNT L+Y+ N +T+N  DP  QF+WL++ ++ ++    K++++ H+P G   ++      +  N+N +LV I ++  E +    + H H D+  V+ ++  KPV  IF+ P+VTP + S I   S NP  R Y +    +  SY      Q++  L  +N +Q   W  EY   E   +  I  G L +L
Sbjct:   36 FWHISDLHLDPTYHVTEDHTKVCFSSKGVPALDPGVFGDFLCDSPYQLILSAFSYMKQVDLQPEFIIWTGDSPPHVPKEELSTDVVINVIANMTRTIQQFFPQIPVYPALGNHDYWPQD---QFPTSENAIYDAVAKLWSPWLN---PAAVATLQKGGFYSLVIKPG---LRLLSLNTNLYYSPNEVTVNMSDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTA-MRENYNEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIK-SQIEPFSNNPGVRAYLY----QPDSYTLLDIWQFYLNLTEANLEQRSGWKLEYIMTEAFGIDDIQPGSLQEL 385
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:ZFIN;Acc:ZDB-GENE-050327-61])

HSP 1 Score: 76.6406 bits (187), Expect = 1.559e-15
Identity = 51/176 (28.98%), Postives = 87/176 (49.43%), Query Frame = 2 
Query:  755 NQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIG--SVNPSFRLYKWSTTAENSSYD-----QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKL 1255
            N  DP  QF+WL++ ++ ++    K++++ H+P G   ++      +  N+N +LV I ++  E +    + H H D+  V+ ++  KPV  IF+ P+VTP + S I   S NP  R Y +    +  SY      Q++  L  +N +Q   W  EY   E   +  I  G L +L
Sbjct:    1 NMSDPAGQFQWLQETLELSRQSMEKVYVIAHVPIGYLPFAKNTTA-MRENYNEQLVKIFRNYSEVVEGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIK-SQIEPFSNNPGVRAYLY----QPDSYTLLDIWQFYLNLTEANLEQRSGWKLEYIMTEAFGIDDIQPGSLQEL 170
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222])

HSP 1 Score: 73.559 bits (179), Expect = 3.051e-13
Identity = 65/228 (28.51%), Postives = 112/228 (49.12%), Query Frame = 2 
Query:  452 KFNETIVMVSNEIF-NIFSSAIVIPSLGNHDIMPRN------VIQNYSP-WCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKT--NKPVVPIFLAPSVTPFRLSTIGSVNPSFRLY 1105
            + NE +V +S  I  ++  +  V P++GNH+  P N      V  N+S  W  ++  + +++   L    +E  ++G FYS  ++ + G  LV +           L +N  DP DQ +WL Q +Q ++N   K+ ++GHIPPG             S+++     I+     TI    F H H+D F++ Y++    +P+   F+APSVT F      ++NP +R+Y
Sbjct:  343 QLNE-LVTISRLIHKHLGRNVTVYPAVGNHESTPVNSFPPPFVHGNHSSRW--LYETMAKEWAPWLPEEALETIRRGGFYS--VEVEPGLRLVSLNMNFCSRENYWLMVNSTDPADQLQWLIQILQESENKGEKVHIIGHIPPG----------FCLSSWSWNYYHIVNRYESTITGQFFGHTHTDEFQMFYDEETLTRPLSVAFIAPSVTTFV-----NLNPGYRVY 550
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: ak9 (adenylate kinase 9 [Source:Xenbase;Acc:XB-GENE-994660])

HSP 1 Score: 182.185 bits (461), Expect = 6.078e-51
Identity = 137/467 (29.34%), Postives = 222/467 (47.54%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLEN-------------------LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTI----GSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILF 1495
            M    ++ L     L+    GYFW + DLHL+    NYS+ +                    GNY  DS  +L+ S++  MKSI  NP+FI+  GD+  H      G+    E I  ++N I   F +  V  +LGNHD  P++ +    P  N  Y+     W  +L N     + + +KG +YS  ++       ++VLNT L+Y  N LT N  DP DQF+WLE ++  A     K+++VGH+PPG  E            FN R ++I+Q ++  I    F H H+D+F++ Y+ +  PV  +F+AP VTP++ +      G+ NP  R+ ++           Y+  L  +N K    W KEY   E   +P  SA  +  ++    S +S Y  K++ Y  +   +D  AC  +  CR   +C+++ VD+  +  C K  S  +  +F++ +  I+  + F
Sbjct:    1 MKAFFFLLLAGSVRLSTTELGYFWHLTDLHLDP---NYSVTSDPRKVCPSAGDQLVPDAGQWGNYLCDSPRILINSSINAMKSILPNPDFILWTGDDTPHVPNEQLGEDAVLEIIRWLTNLIQQTFPTTKVYSALGNHDFHPKSQL---PPHNNSIYDRISEFWSPWLKN---ESLPSFRKGAYYSEELKDVGAAGRMIVLNTNLYYDSNSLTANMKDPGDQFQWLEDQLNNANLKGEKVYIVGHVPPGYFE-KKRDKPWFREEFNKRYIEIIQKHHRVIQGQFFGHHHTDSFRMFYSDSGTPVSSMFIAPGVTPWKTTLPGVENGANNPGIRVVEYDRQNLQDIV-TYYLNLTYAN-KVSPRWEKEYRLTEAYQIPDCSAQSMHDVVKKI-SNDSCYLQKYYKY--NSVSYDLEAC--NKTCRVDHVCAIREVDFNKYKECVKTESSSIRHMFELTVLFIVMPVYF 450
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006])

HSP 1 Score: 143.28 bits (360), Expect = 8.906e-37
Identity = 111/416 (26.68%), Postives = 197/416 (47.36%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMV------SNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXX--WYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLS-TIGSVNPSFRLYKWSTTAENSSYDQYHAI--LPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            G FW I DLHL+             +S+      N    G++  DS   L+ SA+  +K  +   +F+I  GD+  H   K   T +++      ++ I ++    +V P+LGNHD  P++ +        V+  + E +   L    +   +KG +YS+  +S      + +++     +YT N++T+N  DP +QF+WLE  ++ ++    K++++ H+P G   ++  +   +   FN RLV I ++  + I A  + H H D+  V+ ++  KPV  +F+ P+VTP R +    S NP FRLY++ TT +    D +H    L  +N K   +W  EY  +    +  +    L  L+  F    S  F  ++  +L         C  D  C+ Q IC+++YVD  ++  C
Sbjct:   34 GQFWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKE--SEVYTAVAEFWKPWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGYLPFAR-LTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTT-DYHLLDLWHYFLNLTEANLKNESSWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF-DSRVGC--DPLCKLQQICAIQYVDEESYTKC 442
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: smpdl3a (sphingomyelin phosphodiesterase acid-like 3A [Source:NCBI gene;Acc:595006])

HSP 1 Score: 142.124 bits (357), Expect = 1.309e-36
Identity = 111/420 (26.43%), Postives = 198/420 (47.14%), Query Frame = 2 
Query:  248 VGFQGYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMV------SNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXX--WYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLS-TIGSVNPSFRLYKWSTTAENSSYDQYHAI--LPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            +G    FW I DLHL+             +S+      N    G++  DS   L+ SA+  +K  +   +F+I  GD+  H   K   T +++      ++ I ++    +V P+LGNHD  P++ +        V+  + E +   L    +   +KG +YS+  +S      + +++     +YT N++T+N  DP +QF+WLE  ++ ++    K++++ H+P G   ++  +   +   FN RLV I ++  + I A  + H H D+  V+ ++  KPV  +F+ P+VTP R +    S NP FRLY++ TT +    D +H    L  +N K   +W  EY  +    +  +    L  L+  F    S  F  ++  +L         C  D  C+ Q IC+++YVD  ++  C
Sbjct:    6 IGNPRQFWHISDLHLDFSYHITEDRTKVCLSSKGAKASNPGIFGDFVCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTSTIRSLLPDLLVFPALGNHDYWPQDQLPVKE--SEVYTAVAEFWKPWLTEEALSTFRKGGYYSQIYKSNKSAHSLRIISLNTNLYYTPNKVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGYLPFAR-LTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFVTPAVTPIRSALETDSNNPGFRLYQYDTT-DYHLLDLWHYFLNLTEANLKNESSWNLEYIMTKTYQIKDLQPESLEGLVKRFQQPESIEFLYYYKNYLVSF-DSRVGC--DPLCKLQQICAIQYVDEESYTKC 418
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Match: SMPD1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:100487433])

HSP 1 Score: 74.7146 bits (182), Expect = 1.204e-13
Identity = 64/226 (28.32%), Postives = 109/226 (48.23%), Query Frame = 2 
Query:  746 LTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKT--NKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSS-----YDQYHAILPSSNEK--QILAWTKEYSSLEFVPGISAGHLA--KLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMK 1390
            L +N  DP  Q +WL + +Q A+    K+ ++GHIPPG      + ++    N+  R+V+  +S   TI A  F H H D F++ Y++    +PV   F++PSVT F      ++NP +R+Y+       SS     ++ Y   L  +N +  Q   WT  Y +LE   G+ +   A  +LL+    ++   F  F+  H  G  H +  C     C+   +C+++
Sbjct:  279 LLINYTDPAGQLQWLVEVLQEAEEKGEKVHIIGHIPPG------LCLKSWSWNY-YRIVNRYES---TIAAQFFGHTHLDEFEMFYDEETLTRPVSVAFISPSVTTFI-----NLNPGYRVYQIDGEYPESSHMVLDHETYILNLTEANARPGQDPRWTLLYRALETY-GMKSAFPADWELLTRRFLQDERLFQTFWYLHHKG--HVDEVC--QENCKTTLLCALR 484
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3b (sphingomyelin phosphodiesterase, acid-like 3B [Source:MGI Symbol;Acc:MGI:1916022])

HSP 1 Score: 155.606 bits (392), Expect = 2.218e-41
Identity = 123/441 (27.89%), Postives = 202/441 (45.80%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLENL-----------------GNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            M  L W+   A + +     G FW I DLHL+  N   S + L                 G+Y  DS   L+ S+L  MK I   P+FI+  GD+  H      G+A     +  ++N I  +F    V  +LGNHD  P+N     S   N  YN    +W  +L+N         K+G FYS  +   +    VVVLNT L+Y+ N  T    DP +QF+WL   +  A      ++++GH+PPG  E +         +FN   + ++Q ++  I    F H H+D+F++ Y+ T  P+  +FL P VTP++ +  G V    NP  R++++     N      Y   L  +N ++   W +EY   E   VP  S   +   L+  AS+      +++ Y  +   +++  C  +  CR + +C++++V +  + +C
Sbjct:    1 MTLLGWLIFLAPWGVAGAQLGRFWHISDLHLD-PNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQS---NRIYNQVAELWRPWLSNESYALF---KRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNK-AWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHI-LQRYYVY--NSVSYNHLTC--EDSCRIEHVCAIQHVAFNTYATC 428
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpdl3a (sphingomyelin phosphodiesterase, acid-like 3A [Source:MGI Symbol;Acc:MGI:1931437])

HSP 1 Score: 134.806 bits (338), Expect = 6.011e-34
Identity = 115/423 (27.19%), Postives = 197/423 (46.57%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-----QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQY 1432
            G FW + DLHL+              S+   +  N    G+   DS   L+ SA   +K+      F+I  GD+  H            + I  ++  + N+F +  V P+LGNHD  P++ +     + YS   ++W   W      L    I   KKG FYS+ + S  G  ++ +   L +Y  N +TLN+ DP +QF+WLE  +  +   K K++++ H+P G   Y++     +   +N +L+DI +     I    + H H D+  V+ +K   P+  +F+AP+VTP + +    + NP  RL+++    + +  D  QY+  L  +N K    WT EY   +   V  +    L  L+  FA+K+S  F K++ Y+       +A C  D  C+   +C++  +D  ++  C KQ+
Sbjct:   35 GQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLW-KPW------LGEEAISTLKKGGFYSQKVASNPGLRIISLNTNL-YYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYAT-DTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYK-PGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSY-DSSATC--DQHCKTLQVCAIMNLDSMSYDDCLKQH 444
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Match: Smpd1 (sphingomyelin phosphodiesterase 1, acid lysosomal [Source:MGI Symbol;Acc:MGI:98325])

HSP 1 Score: 73.559 bits (179), Expect = 2.613e-13
Identity = 78/338 (23.08%), Postives = 133/338 (39.35%), Query Frame = 2 
Query:  461 ETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-------QNYSPWC-NVWYNIWEKYLNNLDPVE-IENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKT--NKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSS-----YDQYHAILPSSNEK-QILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSM--KYVDYPAF 1411
              +  +++ +        V P++GNH+  P N            S W        WE +L    P + +   + G FY+ T   + G  L+ +           L +N  DP  Q +WL + +Q A+N   K+ ++GHIPPG          H   +++     I+     T+    F H H D F++ Y++   ++P+   FLAPS T F      ++NP +R+Y+       SS     ++ Y   L  +N      +W + Y + E   +P         L+         +   +F YH    P +    P  + CR   +C+      D PA 
Sbjct:  292 RALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWL----PADALHTLRIGGFYALT--PRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPG----------HCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFI-----NLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSE----PCGTPCRLATLCAQLSARADSPAL 604
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q92485|ASM3B_HUMAN (Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2)

HSP 1 Score: 168.318 bits (425), Expect = 4.165e-45
Identity = 127/440 (28.86%), Postives = 202/440 (45.91%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLN----ISNLNYSL------------ENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWS-TTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            M  L W+   A +       G FW I DLHL+    +S   + +               G+Y  DS   L+ S++  MK I   P+FI+  GD+  H      G+A   E +  ++  I  +F    V  +LGNHD  P+N    +    N  YN    +W+ +L+N     I   KKG FY   +   +G   +VVLNT L+YT N LT +  DP  QF+WLE  +  A      +++VGH+PPG  E +          FN + + +++ ++  I    F H H+D+F+++Y+    P+  +F+ P VTP++ +  G V    NP+ R++++   T        Y   L  +N +    W  EY   E   VP  SA  +  +L   A   ST   +++ Y+     +    C  D  C  Q +C+M+ VD  A+ +C
Sbjct:    1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKN---QFPAGSNNIYNQIAELWKPWLSN---ESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQ-NKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQST-LQRYYVYNSVS--YSAGVC--DEACSMQHVCAMRQVDIDAYTTC 428
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|P58242|ASM3B_MOUSE (Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 1.552e-40
Identity = 123/441 (27.89%), Postives = 202/441 (45.80%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLENL-----------------GNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            M  L W+   A + +     G FW I DLHL+  N   S + L                 G+Y  DS   L+ S+L  MK I   P+FI+  GD+  H      G+A     +  ++N I  +F    V  +LGNHD  P+N     S   N  YN    +W  +L+N         K+G FYS  +   +    VVVLNT L+Y+ N  T    DP +QF+WL   +  A      ++++GH+PPG  E +         +FN   + ++Q ++  I    F H H+D+F++ Y+ T  P+  +FL P VTP++ +  G V    NP  R++++     N      Y   L  +N ++   W +EY   E   VP  S   +   L+  AS+      +++ Y  +   +++  C  +  CR + +C++++V +  + +C
Sbjct:    1 MTLLGWLIFLAPWGVAGAQLGRFWHISDLHLD-PNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQS---NRIYNQVAELWRPWLSNESYALF---KRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNK-AWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHI-LQRYYVY--NSVSYNHLTC--EDSCRIEHVCAIQHVAFNTYATC 428
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q641Z7|ASM3A_RAT (Acid sphingomyelinase-like phosphodiesterase 3a OS=Rattus norvegicus OX=10116 GN=Smpdl3a PE=2 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 1.640e-34
Identity = 119/423 (28.13%), Postives = 204/423 (48.23%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-----QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQY 1432
            G FW + DLHL+              S+   ++ N    G+   DS   L+ SA   +K+      F+I  GD+  H            E I  ++  + N+F +  V P+LGNHD  P++ +     + YS   ++W   W      LD   I   +KG FYS+ + S N ++ ++ LNT L+Y  N +TLN+ DP +QF+WLE  +  +   K K++++ H+P G   Y++     +   +N +LVDI +     I    + H H D+  V+ +K   P+  +F+AP+VTP + +    + NP  RL+++    + +  D  QY+  L  +N K    WT EY+  +   V  +    L  L    A+ +S  F K++ Y      +D++A P D +C+   IC++  +D  ++  C K++
Sbjct:   35 GQFWHVTDLHLDPTYHITDDHTKVCASSKGANVSNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVRELSTGSVIEVITNMTVTVQNLFPNLQVFPALGNHDYWPQDQLPIATSKVYSAVSDLW-KPW------LDEEAISTLRKGGFYSQKVAS-NPDLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLRNKEKVYVIAHVPVGYLPYAT-KTPAMRQYYNEKLVDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPINSVFVAPAVTPVKGVLEKETNNPGVRLFQYK-PGDYTLLDMLQYYLNLTEANLKGESNWTLEYTLTQAYGVADLQPKSLHGLAQQLATIDSKQFLKYYHYFFVS--YDSSA-PCDQRCKTLQICAIMNLDLVSYEDCLKRH 444
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|P70158|ASM3A_MOUSE (Acid sphingomyelinase-like phosphodiesterase 3a OS=Mus musculus OX=10090 GN=Smpdl3a PE=1 SV=2)

HSP 1 Score: 134.806 bits (338), Expect = 4.205e-33
Identity = 115/423 (27.19%), Postives = 197/423 (46.57%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-----QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQY 1432
            G FW + DLHL+              S+   +  N    G+   DS   L+ SA   +K+      F+I  GD+  H            + I  ++  + N+F +  V P+LGNHD  P++ +     + YS   ++W   W      L    I   KKG FYS+ + S  G  ++ +   L +Y  N +TLN+ DP +QF+WLE  +  +   K K++++ H+P G   Y++     +   +N +L+DI +     I    + H H D+  V+ +K   P+  +F+AP+VTP + +    + NP  RL+++    + +  D  QY+  L  +N K    WT EY   +   V  +    L  L+  FA+K+S  F K++ Y+       +A C  D  C+   +C++  +D  ++  C KQ+
Sbjct:   35 GQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLW-KPW------LGEEAISTLKKGGFYSQKVASNPGLRIISLNTNL-YYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYAT-DTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYK-PGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSY-DSSATC--DQHCKTLQVCAIMNLDSMSYDDCLKQH 444
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q3ZC91|ASM3A_BOVIN (Acid sphingomyelinase-like phosphodiesterase 3a OS=Bos taurus OX=9913 GN=SMPDL3A PE=2 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 5.037e-33
Identity = 118/420 (28.10%), Postives = 198/420 (47.14%), Query Frame = 2 
Query:  260 GYFWDICDLHLN-----------ISNLNYSLEN-----LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH-------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNY-SPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV--NPSFRLYKWSTTA-ENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQY 1432
            G FW + D HL+           +   +   E       G+   DS   L+ SAL  +K+      F+I  GD+  H        D   N T   ++  I  +F +  V P+LGNHD  P++ +    S   N   N+W+ +L       I   +KG FY++ + S N  + ++ LNT L+Y  N +TLNQ DP +QF+WLE  +  ++  K K++++ H+P G   Y+   I  +    N +L+DI +   + I    + H H D+  V+ +K  KPV  +F+AP+VTP R S +  +  NP  RL+++     +     QY+  L  +N K    W  EY+  +   +  +    L KL   FA + S  F K++ Y        +++     +C+   IC++  +D  ++  C++QY
Sbjct:   35 GQFWHVTDFHLDPTYHITGDHTKVCASSKGAEASDPGPFGDVMCDSPYRLIFSALDFIKNSGQKVSFMIWTGDSPPHVPVLELSTDKVINVT-ANITTTIQRLFPNLQVFPALGNHDYWPQDQLPVVNSKVYNAVANLWKPWLTE---DAITTLRKGGFYTQKV-SNNPKLRIISLNTNLYYGPNSVTLNQTDPANQFEWLENTLNISQQNKEKVYIIAHVPVGYLPYAR-GISAMRKYHNEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKKGKPVNSLFVAPAVTPVR-SVLERLTNNPGVRLFQYDPRDYKLLDMLQYYLNLTDANLKGESNWKLEYNLTQAYDIQDLQPKSLYKLAKQFAIQESKQFIKYYKYFFVSY---DSSVICQGKCKIFQICAIMNLDVISYTDCFRQY 444
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A0V0JC01 (Acid sphingomyelinase-like phosphodiesterase 3b OS=Schistocephalus solidus OX=70667 GN=ASM3B PE=4 SV=1)

HSP 1 Score: 204.527 bits (519), Expect = 3.082e-53
Identity = 136/431 (31.55%), Postives = 218/431 (50.58%), Query Frame = 2 
Query:  254 FQGYFWDICDLHLNISNLNYSLE-NLGNYKSDSTILLMKSALIEMKSIYSNP-EFIIVNGDNMFHGD----AKFNETIVMVSNEIFNIF--SSAIVIPSLGNHDIMPRNVIQNYSP-------WCNVW---YNIWEKYLNNLDPVEIENAKK--------GCFYSRTIQSKNGXXXXXXXX-XXXWYTRNRLTLNQL-DPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKW-STTAENSSYDQYHAILPSSNEKQILAWTKEYSSLE--FVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACP-YDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVAL 1450
            F+G FW + D H++    NYS + +LGNY+ DS + L  SAL   + +   P +F+I +GD++ H +    AKF + +   +  +  +F  +   +IP LGNHD  P NV++   P       WC +     ++W  ++    P    NA +        GCF+SR +    G+ LV++    +LWY+ NR     L DP  QF WLE  +  A+    K+ L+ H PPG +E S     H    +N R +D++  N + +  G+FAHQH+D F+V+  K ++P +P+   PS++P+RL  +G+ NP  R++++   +   + Y Q    L ++       W +EYS  +   +P  SAG L+ LL+DF      +   +F + L G PH +  CP   S  R Q +C+M Y+ Y     C    S G  L
Sbjct:   36 FRGSFWHVTDPHIDP---NYSCQGSLGNYECDSPLSLWISALNNTRQLRQQPPDFVIFSGDSVAHTESLSRAKFLDVMRSAAKRLRALFPDNQIPIIPVLGNHDTHPSNVLEVNEPAAQKRHEWCGLLATDRDLWADWIALGQPDPAPNATRNSSEVFTSGCFFSRRLNISGGSSLVLISVNGMLWYSNNRKADASLPDPVGQFAWLEATLSRARESNTKVLLICHFPPGATENSPEKYRHFFEKYNQRFLDLLLDNADILIGGLFAHQHTDTFRVL-KKDDRPALPLLFGPSISPWRLGGLGAFNPRIRVFQYVRRSLRLTDYQQLFLNLSAAEPT----WAEEYSFRQEYRLPDTSAGSLSALLTDFVHSEGNWTRYWF-HQLGGLPHGSGDCPQLGSLHRCQHLCAMFYLSYTYLDRCLIGCSAGSPL 457
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A5K3FBP9 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 198.364 bits (503), Expect = 4.018e-52
Identity = 127/419 (30.31%), Postives = 212/419 (50.60%), Query Frame = 2 
Query:  260 GYFWDICDLHLNISNLNYSLE-NLGNYKSDSTILLMKSALIEMKSI-YSNPEFIIVNGDNMFHG---DAKFNETIVMVSNEIFNIFSS---AIVIPSLGNHDIMPRN------VIQNYSPWCNVWYN---IWEKYLNNLDPVEIENAKKGCFYSRTIQ---SKNGXXXXXXXXXX--XWYTR--NRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKW---STTAENSSYDQYHAILPSSNEKQIL--AWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPY---DSQCRHQFICSMKYVDYPAFYSC 1420
            G+FW + D+HL++    +    + G+   DS   L+ SAL   + I  + P+F++ +GD+  H    +  F   + +V+  +   F S     VIPSLGNHD+ P +      V +N   WC    +   +W  ++      +      GCF+SR ++   + NG    +++ +L  L Y+R  ++   N  DP  QF+WL  ++Q A++ K K  ++ H P G  E S +   H++  +N RL+ I+    + I  G+F HQH D+F+VV++KT  P++P+F +PSV+P  L+ +GS NP  R Y +   S T     Y Q++  + +      L  A  + Y   +  P   AG LA+L  D A      +  ++++ L GQPHD+  CP       CRH  +C+M+++ Y    SC
Sbjct:   28 GHFWQLTDVHLDLDYERHGCSGDFGDCDCDSPRQLLVSALQATRKIAVAEPDFVVFSGDSTAHAIESETDFERAMKVVATSLKETFPSHRNIPVIPSLGNHDVFPESSMSVNEVDENRRRWCTRLGSDPELWADWVTGPKDADASRFSDGCFFSRLLRINSTANGTQKHLLVISLNGLLYSRRNSQADPNVTDPLGQFQWLLSKLQSARDEKQKAIIIMHFPLGAPENSPVQFRHMYDVYNERLIGILTDFADVISFGLFGHQHVDSFRVVFSKTGDPLLPLFYSPSVSPMYLNALGSFNPRIRFYNYTFGSATPRILDYQQFYVNISADQPSWRLEYAARQAYGLADLSPQSLAGLLARLGDDAA-----IWCSYWNHELGGQPHDSGPCPELHSKRHCRH--LCTMRHLSYSVLDSC 439
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: H2KQ49 (Acid sphingomyelinase-like phosphodiesterase 3b OS=Clonorchis sinensis OX=79923 GN=CLF_103221 PE=4 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 3.118e-51
Identity = 141/448 (31.47%), Postives = 228/448 (50.89%), Query Frame = 2 
Query:  260 GYFWDICDLHLNI-SNLNYSLENL-GNYKSDSTILLMKSA------LIEMKSIYSN-PEFIIVNGDNMFHGD----AKFNETIVMVSNEIFNIFSS--AIVIPSLGNHDIMPRNVIQ------NYSPWCN------VWYNIWEKYLNNLDPVEIE---------------NAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLN-QLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNST--YFNKFFSYHLSGQPHD------NAACPY-DSQCRHQFICSMKYVDYPAFYSCWKQYSR 1438
            G+FW + DLHL++  NL    +   GN K DS + L++SA      L  ++S Y   P+F+I +GDN  H       +  +TI +VS+++  +F +    V+P LGNHD+ P N +       +   WC+      + +  W    N    ++ E               N  +GCF+S  +      +L+V +N L+WY  N L ++   DP  QF WL     +A++ K K+ LV H PPG SE S    + L S FN   V ++Q+N + + AG+FAH H D+F+V+ ++T  P + +F APSV+P RL  +GS NP  RLY++  +      Y QY   +   + +    W  EY  S    +  +S   L++LL++F   ++    +++++S+ L G+PH+      +  CP   S CR + +C M++VD PA  SC    +R
Sbjct:   28 GFFWQLTDLHLDLWYNLTQDCQGRYGNPKCDSPLDLVQSAVSVTKTLPMLESDYRQLPDFVIWSGDNGPHAGHFTRDQLYQTIQVVSDQMQRVFRTDKVYVLPVLGNHDVTPANHLSPDPLDADRLAWCHNLSSNPLLWGHWIHLANRTSFIDPERSTQRDLPPSPPPPANFSRGCFFSHLLHLPTSELLLVSVNGLVWYRENPLLVHASPDPLQQFDWLNATFAWARSSKCKVLLVSHFPPGASENSPRRFKFLQSGFNKHFVQLLQANADVLMAGLFAHSHVDSFRVLSDQTGHPALSLFTAPSVSPLRLFGLGSFNPRIRLYRYRRSNTTLLGYRQYFLNISQPSPQ----WQVEYDTSVAYLLSDLSPIRLSQLLNEFEHDDTRDGVWSRYWSHELGGRPHEPSTLMPDGLCPRAQSLCRCEHLCPMRHVDLPAMESCLDSCTR 471
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A3R7F2S1 (Acid sphingomyelinase-like phosphodiesterase 3b OS=Clonorchis sinensis OX=79923 GN=SMPDL3B PE=4 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 3.179e-51
Identity = 141/448 (31.47%), Postives = 228/448 (50.89%), Query Frame = 2 
Query:  260 GYFWDICDLHLNI-SNLNYSLENL-GNYKSDSTILLMKSA------LIEMKSIYSN-PEFIIVNGDNMFHGD----AKFNETIVMVSNEIFNIFSS--AIVIPSLGNHDIMPRNVIQ------NYSPWCN------VWYNIWEKYLNNLDPVEIE---------------NAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLN-QLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEY--SSLEFVPGISAGHLAKLLSDFASKNST--YFNKFFSYHLSGQPHD------NAACPY-DSQCRHQFICSMKYVDYPAFYSCWKQYSR 1438
            G+FW + DLHL++  NL    +   GN K DS + L++SA      L  ++S Y   P+F+I +GDN  H       +  +TI +VS+++  +F +    V+P LGNHD+ P N +       +   WC+      + +  W    N    ++ E               N  +GCF+S  +      +L+V +N L+WY  N L ++   DP  QF WL     +A++ K K+ LV H PPG SE S    + L S FN   V ++Q+N + + AG+FAH H D+F+V+ ++T  P + +F APSV+P RL  +GS NP  RLY++  +      Y QY   +   + +    W  EY  S    +  +S   L++LL++F   ++    +++++S+ L G+PH+      +  CP   S CR + +C M++VD PA  SC    +R
Sbjct:   28 GFFWQLTDLHLDLWYNLTQDCQGRYGNPKCDSPLDLVQSAVSVTKTLPMLESDYRQLPDFVIWSGDNGPHAGHFTRDQLYQTIQVVSDQMQRVFRTDKVYVLPVLGNHDVTPANHLSPDPLDADRLAWCHNLSSNPLLWGHWIHLANRTSFIDPERSTQRDLPPSPPPPANFSRGCFFSHLLHLPTSELLLVSVNGLVWYRENPLLVHASPDPLQQFDWLNATFAWARSSKCKVLLVSHFPPGASENSPRRFKFLQSGFNKHFVQLLQANADVLMAGLFAHSHVDSFRVLSDQTGHPALSLFTAPSVSPLRLFGLGSFNPRIRLYRYRRSNTTLLGYRQYFLNISQPSPQ----WQVEYDTSVAYLLSDLSPIRLSQLLNEFEHDDTRDGVWSRYWSHELGGRPHEPSTLMPDGLCPRAQSLCRCEHLCPMRHVDLPAMESCLDSCTR 471
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Match: A0A075A8F6 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=T265_14569 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 1.180e-49
Identity = 136/442 (30.77%), Postives = 229/442 (51.81%), Query Frame = 2 
Query:  260 GYFWDICDLHLNIS-NLNYSLENL-GNYKSDSTILLMKSALIEMKSI-------YSNPEFIIVNGDNMFHG----DAKFNETIVMVSNEIFNIFSS--AIVIPSLGNHDIMPRN------VIQNYSPWC----------NVWYNIWEK--YLNNLDPVEIE---------NAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLN-QLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEYSSLE--FVPGISAGHLAKLLSDFASKNST--YFNKFFSYHLSGQPHD------NAACPY-DSQCRHQFICSMKYVDYPAFYSC 1420
            G+FW + DLHL++  NL    +   G+ K DS + L++SA+   K++          P+F+I +GDN  H       +  +TI +VS+ +  +F +    V+P LGNHD+ P N      +  +   WC            W ++  +  ++N    ++ +         N  +GCF+S  +     ++L+V +N L+WY  N L ++   DP  QF WL     +A++ K KI LV H PPG SE +    + L S FN   V ++Q+N + + AG+FAH H D+F+V+ ++T  PV+ +F APSV+P RLS +GS NP  RLY++  +      Y QY   +  S+ +    W  EY + +   +  +S   L +LL++F   ++    +++++++ L G+PH+      +  CP   S CR + +C M++VD  A  SC
Sbjct:   28 GFFWQLTDLHLDLRYNLTQDCQGRYGDPKCDSPLDLVQSAISVTKTLPMFESDDRQLPDFVIWSGDNGPHAHHFTRDQLYQTIQVVSDRMQQVFRTDKVYVLPVLGNHDVTPANHMSPDPLDADRLAWCHNLSSNPLLWGPWIHLANRSSFINPDRSIQRDLPSPLPPPANFSRGCFFSHLLHLPTSDLLLVSVNGLIWYRENPLLVHASPDPLQQFDWLNATFAWARSSKCKILLVSHFPPGASENTPRRFKFLQSGFNKHFVQLLQANADVLMAGLFAHTHVDSFRVLSDQTGHPVLSLFTAPSVSPLRLSGLGSFNPRIRLYRYRRSDTTLLGYRQYFLNISQSSPQ----WQVEYDTSDAYLLSDLSPIALNRLLNEFEHDDTQDGVWSRYWNHELGGRPHEPSTLIPDGLCPRAQSVCRCEHLCPMRHVDLTAMQSC 465
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:103027922])

HSP 1 Score: 160.999 bits (406), Expect = 2.449e-43
Identity = 125/428 (29.21%), Postives = 209/428 (48.83%), Query Frame = 2 
Query:  254 FQGYFWDICDLHLNISNLNYSLEN-------------------LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI---QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRI-QYAKNMKIKIFLVGHIPPGTSEYSSIIIEH---LHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLS----TIGSVNPSFRLYKW-STTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
              G FW I DLH + +   YSL                      G+Y  DS   L+ S++  M+ I  +P+FII  GD+  H      G+      I  ++  I  +F S  V  +LGNHD  P++ +   QN     +++  I +++ + LDP   +  KKG +Y+  + ++ G  ++V+   L +Y +N++T N  DP DQF+W +Q + + AKNM+ K+++VGH+PPG  E       H       FN   ++++Q +++ I    F H H+D+F++ Y+K   P+  +FL P VTP++ +      G+ NP  R++++   T        Y+  L  +N  +   W KEY   E   VP  S   +  +L   A  N  Y  K++ ++     +D  AC  D  CR   +C+M+ VD+ A+  C
Sbjct:   22 LTGSFWHITDLHWDPT---YSLNGNSASVCNSSGNRPTPDAGKFGDYLCDSPWDLINSSMHAMRDILPDPDFIIWTGDDTPHVPNEDLGEEAVLRIIGNLTQIIKELFPSTKVYSALGNHDYHPKSQLPPEQN-----SIYEQIQKQWESWLDPASRDTFKKGGYYTEKLLNQTGLRVLVLNTNL-YYDQNKITENINDPADQFRWADQVLSEAAKNME-KVYIVGHVPPGFFEKK----RHKPWFRPQFNKHYLELIQKHHDIIIGQFFGHHHTDSFRLFYDKAGIPISAMFLTPGVTPWKTTLPGVDDGANNPGIRVFEYDEKTLLVKDMITYYLNLTHANIARA-RWEKEYRLTEAFGVPDASPASMHHVLEQIAGDNC-YLQKYYDFNSVN--YDRTACGAD--CRVDHVCAMREVDFDAYELC 429
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:103046912])

HSP 1 Score: 154.836 bits (390), Expect = 3.005e-41
Identity = 126/431 (29.23%), Postives = 200/431 (46.40%), Query Frame = 2 
Query:  239 HLTVGFQGYFWDICDLHLN-------------ISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVS------NEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN----IWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTAEN-SSYDQYHAILPSSNEKQILAWTKEYSSLE--FVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRG 1441
            HL     G FW I DLHL+              S+  + ++N    G++  DS   L+ SA   MK +   PEFII  GD+  H   +   T  ++S      + I   F    V P+LGNHD  P++ +   +   N  Y     +W  +L++     +   ++G FYS+ I+     + VV LNT  +YT N+ T N  DP  QFKWL+  ++ +K    K++++ H+P G   Y+      +  + N +LVDI +S    I    + H H D+  V+ ++  KPV  IF+ P+VTP +      S NP  R+Y + T         QY+  L  +N+K+   W+ EY+  E   +  I    L +L   F +  S  F K+F+ H      D   C  +  C+   +CS+ Y+D  ++  C K+   G
Sbjct:   30 HLQTATTGKFWHISDLHLDPTYHITTDPSKVCFSSKGFPVKNPGLFGDFLCDSPYQLILSAFSHMKHVEQQPEFIIWTGDSPPHVPPEELSTDAVISVTSNMTHTIRQFFPQLPVYPALGNHDYWPQDQLPAKT---NAVYEAVAKLWAPWLSS---EALATLREGGFYSQLIKPG---LRVVSLNTNFYYTPNKATENLTDPGGQFKWLQDTLELSKQSLEKVYVIAHVPIGYLPYAKDTTA-MREHHNEKLVDIFRSYSSIIQGQFYGHTHRDSIMVLLDQQGKPVNSIFVTPAVTPIKSPGEPFSNNPGVRMYLFDTQDYGLQDLWQYYLNLTEANKKEQPNWSLEYTMTEAFAIKDIQPQSLHELALKFEAPQSKDFQKYFT-HFMVSYSDTITC--EGVCKMVQVCSVHYLDRDSYSQCMKKRRAG 447
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:ZFIN;Acc:ZDB-GENE-041008-132])

HSP 1 Score: 129.413 bits (324), Expect = 9.000e-33
Identity = 125/450 (27.78%), Postives = 204/450 (45.33%), Query Frame = 2 
Query:  209 LLWIFLGALFH---LTVGFQGYFWDICDLHLNISNLNYSLEN------------------LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI--QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPG----TSEYSSIIIEHLHSNFN-----SRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLS----TIGSVNPSFRLYKWS-TTAENSSYDQYHAILPSSNEKQI-LAWTKEYS-SLEF-VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            LLW  L A+F    L V   G FW I DLH++ +   Y + +                  LG+Y+ D+   L+ SAL  MK I  NP+FI+  GD+  H      G+    E I  +++ I   F    V  +LGNHD  P+N +   N S +  V  ++W+ ++    P  +    KG +YS  +  + G  +VV+   L +Y  N  T    DP  QF WL++ +  A   K K+F++GH+PPG    T E S     +   +++      R+    QS Y          +     ++V    N  V  + +AP +TP++ +      G+ NP  R++++   T +      ++  L ++N   +   W++EYS  L+F VP  S   L  LL    + +   F K+  Y+ +   +D  AC  D+ CR    C++  VD+ A+  C
Sbjct:    2 LLWSILLAVFGKYLLAVSKSGKFWHITDLHVDPA---YQVTDNSTAVCPSSRDPVLNPGPLGHYQCDAPWALIHSALNNMKRILKNPDFILWTGDDTPHVPDSALGEEAVLEIIKNLTDIITAAFPGVTVYSALGNHDFHPKNQLPPHNNSIYSRVG-SMWQHWMA---PESLGTFHKGAYYSEKLVGRAGQRIVVLNTNL-YYASNVQTAGLADPAGQFDWLDKVLTNASANKEKVFIIGHVPPGMXSETREGSGRRECYCDKHYSVARLPHRVTTSAQSGYT---------RGGGRGELVRGAGNA-VSSMLIAPGITPWKTTLPGVDDGANNPGIRVFEYDKATLQLQDMLTHYIDLQTANSGNLDPVWSQEYSLRLDFSVPDASTAALDSLLQKM-NADPDLFQKY--YNFNSVSYDKRAC--DAACRDDHYCAIGEVDFDAYEGC 428
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc:ZDB-GENE-110411-222])

HSP 1 Score: 63.5438 bits (153), Expect = 5.311e-11
Identity = 72/327 (22.02%), Postives = 134/327 (40.98%), Query Frame = 2 
Query:  461 ETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-------QNYSPWC-NVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKT--NKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSS-----YDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMK 1390
            + +  V+  I     +  V P++GNH+  P N          + S W  +     W  +L +   V +   + G FY  T  +K G  +V +           L +N  DP  Q +W    +Q A+N   K+ ++GHI PG               ++     I+     TI A  F H H+D F++ Y++   ++P+   +L+PSVT     T   +NP +R+Y+     ++S+     +  ++  L  +N      W   YS+ +   +  +       LL      ++ +    F +HL  + H +  C     C+   +C+++
Sbjct:  183 QALTTVTELIRKYLGNTTVYPAVGNHESSPVNSFPPPSAPGHHSSAWLYDAMAKAWSHWLPSDALVTL---RFGGFY--TALAKPGLRVVSLNMNFCSVENFWLAINDTDPAGQLQWFVDVLQAAENNGEKVHVIGHIAPGLCR----------KTWSWNYYHIINRYESTIAAQFFGHVHTDQFEMFYDEETLSRPLGVAYLSPSVT-----TYWDLNPGYRVYEIDGDRKDSTRAVLDHHTFYLDLEEANRLDRPTWRLLYSARKAYGMEALGPADWDALLHRMQDDDALF--AIFWWHLH-KGHSSEPCI--GMCKVAMLCALR 484
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO31208 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYL6])

HSP 1 Score: 90.1225 bits (222), Expect = 9.198e-20
Identity = 91/355 (25.63%), Postives = 158/355 (44.51%), Query Frame = 2 
Query:  395 YSNPEFIIVNGDNMFHG--DAKFNETIVMVSNE---IFNIFSSAIVIPSLGNHDIMPRNVI-------QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQS--KNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNK--PVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSS-----YDQYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDS-QCRHQFICSM 1387
            YS  ++++  GD   H   +   N  +  + N    I +      V P++GNH+  P N         +N + W      + + + N L    +   KKG FYS  +    +  ++ +   N + W+    L L+ +DP  Q +WL   +Q +++   K+ ++GHIPPG+S+     ++    N+ S    I+     T+ A  F H HSD F+V Y++  +  P+   FL PSVTP++       NP +R+Y      +NSS     ++ Y   L  +N+ ++  WT EY++ +   +P +       LL    +K+ +     + Y     P        DS  C+  FIC M
Sbjct:    1 YSQVDYVLWTGDIPPHNIWNQSRNAQLKSLDNAVDLILHYLPGVKVFPAIGNHEGSPVNSFPPPSITDENSNSWLR--NELAKDWGNWLPEYTMSTIKKGAFYSVLVSKGLRIVSINMNYCNNMNWW----LLLDSIDPAGQLQWLVDTLQESEDNGEKVHIIGHIPPGSSD----CLKAFSWNYYS----IINRYQSTVTAQFFGHTHSDEFEVFYDEKTRRIPISFAFLGPSVTPYQFH-----NPGYRIYDIDGDYDNSSRVVLNHETYILDLIEANKGEV-QWTLEYNAKDAYKMPSLLPSAWHDLLIRM-TKDPSLVELAYKYFYKSSPESIHGGKCDSPSCQKSFICRM 334
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46993 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNV6])

HSP 1 Score: 81.2629 bits (199), Expect = 2.296e-16
Identity = 108/420 (25.71%), Postives = 173/420 (41.19%), Query Frame = 2 
Query:  308 NYSLENL----GNYKSDSTILLMKSALIEMKSIYS--NPEFIIVNGDNMFHG-------DAKFNETIV----MVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYN---------IWEKYLNNLDPVEIENAK------KGCFYSRTIQSKNGXXXXXXXXXXXW--YTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAG-IFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRL-----STIGSVNPSFR-LYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVPG----ISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQY 1432
            NYS  N     G    DS  +L+ S +  M+S+Y     +F+I+ GD   H          K +E ++    + S +I N F    V P LGN+D     V+ N S   + WYN         I     +  D      A+       G +Y   +   +G +++++LN++ W  Y   +    Q+    Q  WLEQ++++AK    K+F+ GHIPPG   +          N  +R  +++   Y  I AG  FAH H D FK+    T++      L  S T F L     S + + NP+FR +Y          YDQ+   +  + E     W  +Y   E  P     I+   + +L  +    N ++ N + +Y  S      A+    S  R    C+M++V    +  C   Y
Sbjct:  119 NYSTANYKAPYGRVGCDSPEILIDSLVKGMRSVYDEKGADFMIITGDMSSHKTDASYLPKGKTSERVLHNIKLASAKIHNAFPKIPVFPMLGNNDFEGHYVLPNTSH--DQWYNKTLEVFAPMILCSNCSTQDTAATTMAELKTTFLDGGYYK--VHIADGRMILLILNSMYWNPYAVEKSYNVQVIAKRQLDWLEQQLEFAKKESKKVFIAGHIPPGIDPFGDKGTPFWMENCTARYTNMIVGKYSDIVAGQFFAHIHQDDFKLQMFNTSQ-----HLTGSKTSFALLNPSVSVVYANNPAFRQVYLDRKELAILDYDQHFLDIVMATEFNAPNWQLDYRFSEHYPSANKYINTDRILELNQNLI--NQSHENAWATYVFSRAVRYQAS----SYSRFGLYCAMRHVIKSEYDKCRSNY 523
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Match: EDO46874 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK9])

HSP 1 Score: 76.2554 bits (186), Expect = 1.146e-14
Identity = 97/378 (25.66%), Postives = 158/378 (41.80%), Query Frame = 2 
Query:  266 FWDICDLHLN------ISNLNYSLENLGNYKS------------DSTILLMKSALIEMKSIYS-NP-EFIIVNGDNMFH-----------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI------QNYSPWCNVWYN--IWEKYLNNLD-PVEIENAKK----GCFYSRTIQSKNGXXXXXXXXXXXWY------TRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNY-ETIHAGIFAHQHSDAFKVVYNKTNKPVVP---IFLAPSVTPFRLSTIGSVNPSFR-LYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVPGIS 1234
            F    DLH +      +S  N     LGNY S            DS + LM S L  MKS +  NP +F+++ GD   H           G  +   +I  ++ EI N F    V P  GN+D  P N +      Q YS   +++    + +K   + + P   +  ++    G +Y   I    G ++++ LN++ WY      + +  T  Q     QF WLE +++ AK    K+ +  H+PPG   YS+  +     + + R  +++   Y E + A ++ H H D  ++   + ++  V      L PSV+P     I + NPS+R  Y          YDQY   +  + + Q   W  +Y   E  P  S
Sbjct:  123 FLVASDLHYDTFYDESVSEENTLCRKLGNYTSAKFNATLGRVGCDSPMSLMTSWLKHMKSTHEKNPADFLLITGDFNAHRTDESYFPHGSGRQRLLSSIKSITLEIHNAFPDLPVFPLFGNNDFQPHNTLPSNEQDQFYSQALDLFLPMILCDKCSPDRNRPTTQQELRETFVNGGYYKVDI--AGGRMVLLALNSMYWYVDAHSDSESDSTYIQTKAAQQFNWLEGQLEQAKQQGKKVIITSHVPPGIDSYSNNPL--WLDDASRRFTELVAGRYHEVVAAQLYGHVHRDDIRLQAIQGDEESVNRSFALLTPSVSP-----IFANNPSYRQFYLHPDQLVLLDYDQYFMDIVMATQFQSAQWQLDYRFSERYPSTS 491
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3b (sphingomyelin phosphodiesterase acid like 3B [Source:NCBI gene;Acc:101169562])

HSP 1 Score: 162.155 bits (409), Expect = 8.754e-44
Identity = 129/450 (28.67%), Postives = 210/450 (46.67%), Query Frame = 2 
Query:  233 LFHLTVGFQGYFWDICDLHLNIS----------------NLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH------GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENA-KKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSV----NPSFRLYKWST-TAENSSYDQYHAILPSSNEKQILAWTKEYSSLE--FVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYS-----RGVALLFKIEISLI 1477
            LF   +   G FW I DLH + +                    S    G+Y  DS   L+ S++  MKSI  +P+FII  GD+  H      G+      I  +++ I  IF    V  +LGNHD  P++ +    P  N  YN   +  N+   +E +   KKG +Y+  + ++NG  ++V+   L +Y +N++T N  DP DQF W +Q +  A  +K K++++GH+PPG  E            +N R +D+++ ++  I    F H H+D+F++ YNK   P+  +FL+P VTP+  +  G V    NP  R++++ T T        Y+  L  +N  +   W KEY   E   VP  S   + + L   A+++  Y  K+  Y  +   +D   C   S CR   +C+ + VD+  +  C  +        G  L   I +SL+
Sbjct:   12 LFKGALALTGSFWHITDLHWDPTYEVTDQPELVCASSGKRPALSAGRFGDYVCDSPWHLINSSVYAMKSILPDPDFIIWTGDDTPHVPNEDLGEEAVINIISNLTSAITEIFPHTKVYSALGNHDFHPKSQLPA-GP--NTIYNRTAELWNHWLELESKQTFKKGGYYTEKLLNRNGYRMLVLNTNL-YYDQNQVTQNMDDPADQFNWADQILTEAAAIKEKVYIIGHVPPGFFEKKRSK-PWFAPKYNRRYLDLIEKHHSVILGQFFGHHHTDSFRMFYNKDRLPISTMFLSPGVTPWETTLPGVVNGANNPGIRVFEYDTDTLLVKDVVTYYLNLTHANAARG-RWEKEYRLTESFRVPDASPASMHQTLERLANEHC-YLQKY--YEFNSVSYDLTDC--GSDCRVDHVCAAREVDFDRYEDCLVKEGAASVFSGRLLFLPIAVSLL 450
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpdl3a (sphingomyelin phosphodiesterase acid like 3A [Source:NCBI gene;Acc:101171626])

HSP 1 Score: 121.324 bits (303), Expect = 1.676e-29
Identity = 115/413 (27.85%), Postives = 198/413 (47.94%), Query Frame = 2 
Query:  260 GYFWDICDLHLNIS--------NLNYSLENL--------GNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH--GDAKFNETIVMV----SNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWY----NIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEY--SSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFR-LSTIGSVNPSFRLYKWSTTAENSSYD--QYHAILPSSNEKQILAWTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRH-QFICSMKYV 1396
            G FW I DLHL+ +         + +S + +        G++  DS   L++SA   M  +    +FII  GD+  H   D    + ++ V    ++ I   F +  V P+LGNHD  P++ +   +   N  Y     +W+ +L +     +    +G FYS+ ++     + +V LNT+L+Y  +++T N  DP  QF+WL++ ++ A     KI+++GH+P G   +  ++  I+  H   N RLV I +     I    + H H D+  V+ ++  KPV  +F++P+VTP + +  + S NP FR+Y ++ + + S  D  QY+  L  +NEKQ   W  EY   E   +  +    L +L   F    +  F+ +FS H     + +  C  D + +  Q  C  K V
Sbjct:   32 GRFWHITDLHLDPTYHLAPDPTKVCFSSKGVPAAHAGIYGDFLCDSPYSLIQSAFAHMAPLTQPQDFIIWTGDSPPHVPPDELSTDMVIQVIGNMTHTIREHFPNLTVYPALGNHDYWPQDQMPAST---NAIYKAAAELWKPWLQS---EALLTLSEGGFYSQLVKPG---LRLVSLNTILYYGPDQVTKNMSDPAGQFQWLQETLESAAQNLEKIYIIGHVPVGYLPFVKNTTAIQKRH---NERLVSIFRKYAHVIAGHFYGHTHRDSIMVLLDQRGKPVNSLFVSPAVTPIKNVLELYSNNPGFRMYLYN-SQDYSMLDIWQYYLNLTEANEKQKSDWRLEYIMTEAFGLTDLQPQSLLQLGLSFLEPQTKAFDTYFS-HFMVNYNSSIICAGDCKVKQEQRSCGGKTV 430
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Match: smpd1 (sphingomyelin phosphodiesterase 1 [Source:NCBI gene;Acc:101174765])

HSP 1 Score: 65.855 bits (159), Expect = 6.183e-11
Identity = 89/383 (23.24%), Postives = 152/383 (39.69%), Query Frame = 2 
Query:  329 GNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG------DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVI-------QNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNK--TNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSS-----YDQYHAILPSSNEKQILA-------WTKEYSSLEF--VPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMK 1390
            G Y      L    +L+E  +     +++   GD   H       D +  E  V+      ++  +  V P++GNH+  P N            S W  ++  + E++   L    ++  + G FY+  IQ   G  +V +           L +N  DP +Q +WL   +Q ++    K+ ++GHIPPG    S          ++     I+     T+    F H H D F++ Y++    + V   F+APSVT     T  ++NP +R+Y      + SS     +  Y   L   N  ++L        WT  Y + E   +P +       LL  F S N   F KF  ++L  + H +  C     C+   +C ++
Sbjct:  217 GTYSKCDLPLRTVESLLENAARDGRWDWVYWTGDIPAHNIWSQTRDQQLMELTVISRLVHKHLGPNVTVYPAVGNHESTPVNSFPPPFIHGNRSSGW--LYAAMAEEWAPWLPEPALKTLRYGGFYTVEIQP--GLRVVSLNMNFCARENFWLMVNSTDPANQLQWLVHILQDSEEKGEKVHIIGHIPPGLCLGS----------WSWNYYHIINRYESTVTGQFFGHTHLDEFQMFYDEETMTRAVGVAFVAPSVT-----TYVNLNPGYRVYIVDGNYKGSSRLVLDHATYILNLTEVNRPEVLGNPVKDPKWTLLYRATEAYGLPTMFPSDYDLLLRTFIS-NDRVFQKF--WYLRHKGHVSEVC--KESCKTTILCFLQ 575
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000071517.1 (SMESG000071517.1)

HSP 1 Score: 875.159 bits (2260), Expect = 0.000e+0
Identity = 436/440 (99.09%), Postives = 436/440 (99.09%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFFQDS 1519
            MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSL NLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGNVLVVVLNTLLWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFV GISAGHL KLLSDFASKNSTYFNKFFSYHLSGQ HDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFFQDS
Sbjct:    1 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLANLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGNVLVVVLNTLLWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVAGISAGHLDKLLSDFASKNSTYFNKFFSYHLSGQSHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFFQDS 440
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000078127.1 (SMESG000078127.1)

HSP 1 Score: 372.089 bits (954), Expect = 4.604e-123
Identity = 186/415 (44.82%), Postives = 265/415 (63.86%), Query Frame = 2 
Query:  200 MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFH---GDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTL---NQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCWK 1426
            M     I    +   T  F+G FW +CD+HLN+S  ++  +  G+YKSDS   L+KSA  +MK IY NP+FII+NGDN+ H     + FN+++  VS+E+   F S+I++PSLGNHD+ P N     S WC +    W K+ +N + +EI+   KGC+YSR I   N    V++LNT++WY+ N  T    N  DP +QF WL + +  ++N   K+FL+GHIPPG SEYS  +  HL   FN + + IMQ   + I AG FAHQH+DAFK+VY+  +KPV+P+F++PS++PF LS +GSVNPS RLY W T   +  Y+QYHA L +  + + L+W+ EYSS   +PG+SA HL +L+SDF  ++S +F+KFF+YHLSG+PH+   C     CR   IC ++ +DY    SC K
Sbjct:    1 MKNTFLILFFLVLEETQCFKGVFWHVCDVHLNLSYKSFGRKQFGDYKSDSPFSLVKSAFQQMKKIYPNPDFIILNGDNVRHRTVSQSDFNKSLTDVSDELLQNFPSSIILPSLGNHDVNPANFFDPKSQWCRILLEKWLKFFSN-NSLEIQTFTKGCYYSRRITVNNITAKVIILNTMVWYSFNSHTFTTQNSDDPLNQFAWLNKELIESRNSATKVFLIGHIPPGASEYSPTVFRHLRPGFNMKFLKIMQDFADIIDAGFFAHQHTDAFKIVYDHNDKPVIPLFISPSISPFYLSGLGSVNPSVRLYHWRTDPADRKYEQYHAKL-NDVQTKTLSWSLEYSSNSLIPGLSAFHLNELVSDFTKEDSKHFDKFFTYHLSGRPHEQNECSESISCRCNIICGIQNIDYTKLDSCLK 413
[Close]
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024647.1 (SMESG000024647.1)

HSP 1 Score: 342.428 bits (877), Expect = 1.878e-112
Identity = 192/426 (45.07%), Postives = 262/426 (61.50%), Query Frame = 2 
Query:  254 FQGYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHG---DAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSS---NEKQI-LAWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCW-----KQYSRGVALLFKIEISLILNVILF 1495
            FQG FW ICD+HLN S +   +   GNYK DST  L +S+++ MKS Y+ P+FIIVNGDN +HG   D + N +I  V+ E+   F +  ++PS+GNHDI P N I   S WC  +Y  WE  L N+   +IE  KKGCFY+ +I +KN   +++VLN +LWY  N       DP +QF WL+ ++Q A+   +K+FLV H+ PG +E + +   + H  FN R + ++Q   + I AG FAHQH+DAFK+VYN  N+PV+P+FL+PSVTPF L  +GSVNPS RLY W+ T+  S Y QYH  LP +   N K + + W  EY S    P +SA  L   +S+F+  +S  F  FFSYHLSGQPHD+  CP  S CR +FIC ++ +DY +  SC      K+     A L  + I L L +ILF
Sbjct:   24 FQGTFWHICDIHLNNSFILNDINRYGNYKDDSTFALFQSSVLFMKSSYTYPDFIIVNGDNSYHGKIQDYQLNASISNVTGELRLHFPATAILPSMGNHDINPANFISVNSSWCQNFYKFWESVLPNISNSDIETFKKGCFYTHSIDTKNSKQMIIVLNAILWYQVNSYVKTNSDPLNQFMWLKTKLQLARASMMKVFLVAHVSPGAAESNPVKFHNFHPQFNQRFLKLIQDYADVIDAGFFAHQHTDAFKIVYNSNNEPVIPLFLSPSVTPFNLWQLGSVNPSVRLYVWNGTSAGSRYHQYHTHLPPTGNINSKSVTIEWKLEYVSNTLFPNLSAKSLDGFVSEFSLSSSPSFKSFFSYHLSGQPHDDETCPETSSCRCRFICGIRNIDYTSLDSCLTKCASKERKYDWAWL-AVPIVLFLFIILF 448
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000024635.1 (SMESG000024635.1)

HSP 1 Score: 335.109 bits (858), Expect = 5.087e-110
Identity = 189/431 (43.85%), Postives = 258/431 (59.86%), Query Frame = 2 
Query:  245 TVGFQGYFWDICDLHLNISNLNYSLENLGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILP--SSNEKQI-LAWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSCW-KQYSRGVA-------LLFKIEISLILNVILFIKL 1504
            T  F+G FWDICDLHLNIS         G+++ DS+I L++SA  EMK IY  P+FIIVNGDN++HG+  F E +  V     N+ SS+                       C+++Y +W  +  N    E+E   KGCFYS  ++SK GN+ +V LNT+LWY RN       DP +QF WLE++++  +  K K FL+GH+PPG  E+S+ II+HLHS +N +L+ IMQ   + I AG FAHQH+DAFK+V +   KP++PIF +PSVTPF L  IGS+NPS RLY W+ ++  S Y QYH  +P  ++  K + L+W+ EY+S   + G++A  L  LL DF  +NS YF+ FF YHLSGQ H N  CP+ S+CR QFICSM+ +D      C  K   R +         L KI + +I   IL I L
Sbjct:   16 TKCFEGAFWDICDLHLNISQPTDINGGFGDFRQDSSIGLIRSAFQEMKKIYPYPDFIIVNGDNVYHGNVGFLEPLHNV-----NVNSSS-----------------------CDIFYKVWSVFFQNASQSEVETFIKGCFYSIKVKSKGGNINIVALNTMLWYGRNNYVRALKDPENQFIWLEEKLKIFRKNKEKAFLIGHVPPGILEHSTFIIKHLHSQYNEKLLWIMQDYVDVIDAGFFAHQHTDAFKLVLSSDKKPIIPIFHSPSVTPFNLRGIGSINPSIRLYYWNNSSAASYYHQYHTKIPIVTNISKNVDLSWSLEYNSKSLINGLTAEDLNNLLKDFDQENSKYFDLFFKYHLSGQDHYNLTCPWISKCRCQFICSMQDIDISTAVKCASKCVERDIKPNIESDLKLLKIILPVIFVAILIITL 418
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Match: SMESG000055453.1 (SMESG000055453.1)

HSP 1 Score: 312.383 bits (799), Expect = 8.983e-101
Identity = 173/416 (41.59%), Postives = 252/416 (60.58%), Query Frame = 2 
Query:  218 IFLGALFHL------TVGFQGYFWDICDLHLNISNLNYSLEN---LGNYKSDSTILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAK---FNETIVMVSNEIFNIFSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENAKKGCFYSRTIQSKNGXXXXXXXXXXXWYTRNRLTLNQLDPNDQFKWLEQRIQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYETIHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFRLYKWSTTAENSSYDQYHAILPSS---NEKQILAWTKEYSSLEFVPGISAGHLAKLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVDYPAFYSC 1420
            +FL +LF++      ++GF+G FW I D+HLN+S   ++L N    G+YK+D++  L+ SA+  MK+IY NP FII NGDN +H  A    F E++  VS+EI   F +A ++P+LGNHD+ P ++    S WC      W+ ++N+ +  E +   KGCFYSRTI+S N  V ++VLN++LWY  N+L  ++ DP  QF WL   ++ A   K ++F+V HIPPG SE+S       HS FN R ++I+Q+    I AG F HQH DAFK+VY+   KP +P+FL+PSV+P  L  +GS+NPS RL+ W+++  N  Y QYH  +P+     +   L W  EY S     G+SA  L     D +  NS YF +FF+YHLSG+ HD+ A   +S  R Q +C ++ +DY     C
Sbjct:    1 MFLLSLFYICAAIGSSLGFEGIFWHISDIHLNVS---FNLGNNRWYGDYKNDASFPLVHSAIKAMKTIYHNPLFIIWNGDNAYHRIANRSNFLESLKNVSSEIRFYFPNANILPTLGNHDVNPSSLFNANSTWCEELLIFWKDFVNSSEN-ETKRFLKGCFYSRTIKSGNDTVKIIVLNSMLWYRHNKLVKDERDPLSQFSWLMNELEEAAMKKQRVFVVSHIPPGASEFSPKKFRFFHSKFNKRFLEILQNYSNIIDAGFFGHQHVDAFKIVYDTQGKPKIPLFLSPSVSPLHLKGLGSINPSIRLFFWNSSLSNCKYQQYHTTIPNELNNTKNNTLNWILEYDSKTLYSGLSAEDLDNFSLDLSKDNSIYFERFFTYHLSGRSHDSGASN-NSTIRCQIVCGLRNIDYTNLDKC 411
The following BLAST results are available for this feature:
BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SMPDL3B8.672e-4628.86sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3B1.624e-3729.85sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3B4.260e-3426.22sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
SMPDL3A4.799e-3227.99sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
SMPDL3A6.336e-3029.10sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ZK856.53.288e-3527.84pep chromosome:WBcel235:V:10186012:10190157:-1 gen... [more]
ZK856.53.288e-3527.84pep chromosome:WBcel235:V:10186023:10190366:-1 gen... [more]
ZK856.53.288e-3527.84pep chromosome:WBcel235:V:10186023:10190131:-1 gen... [more]
asm-12.565e-1524.93Sphingomyelin phosphodiesterase 1 [Source:UniProt... [more]
asm-12.565e-1524.93Sphingomyelin phosphodiesterase 1 [Source:UniProt... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG320522.892e-3024.52gene:FBgn0044328 transcript:FBtr0347598[more]
CG320522.892e-3024.52gene:FBgn0044328 transcript:FBtr0347599[more]
CG320522.892e-3024.52gene:FBgn0044328 transcript:FBtr0332818[more]
CG33761.002e-1022.41gene:FBgn0034997 transcript:FBtr0072265[more]
CG33761.015e-1022.41gene:FBgn0034997 transcript:FBtr0343442[more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
smpdl3b8.767e-4328.64sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a5.705e-3029.04sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpdl3a1.559e-1528.98sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpd13.051e-1328.51sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ak96.078e-5129.34adenylate kinase 9 [Source:Xenbase;Acc:XB-GENE-994... [more]
smpdl3a8.906e-3726.68sphingomyelin phosphodiesterase acid-like 3A [Sour... [more]
smpdl3a1.309e-3626.43sphingomyelin phosphodiesterase acid-like 3A [Sour... [more]
SMPD11.204e-1328.32sphingomyelin phosphodiesterase 1 [Source:NCBI gen... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Smpdl3b2.218e-4127.89sphingomyelin phosphodiesterase, acid-like 3B [Sou... [more]
Smpdl3a6.011e-3427.19sphingomyelin phosphodiesterase, acid-like 3A [Sou... [more]
Smpd12.613e-1323.08sphingomyelin phosphodiesterase 1, acid lysosomal ... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q92485|ASM3B_HUMAN4.165e-4528.86Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
sp|P58242|ASM3B_MOUSE1.552e-4027.89Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
sp|Q641Z7|ASM3A_RAT1.640e-3428.13Acid sphingomyelinase-like phosphodiesterase 3a OS... [more]
sp|P70158|ASM3A_MOUSE4.205e-3327.19Acid sphingomyelinase-like phosphodiesterase 3a OS... [more]
sp|Q3ZC91|ASM3A_BOVIN5.037e-3328.10Acid sphingomyelinase-like phosphodiesterase 3a OS... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0V0JC013.082e-5331.55Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
A0A5K3FBP94.018e-5230.31Uncharacterized protein OS=Mesocestoides corti OX=... [more]
H2KQ493.118e-5131.47Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
A0A3R7F2S13.179e-5131.47Acid sphingomyelinase-like phosphodiesterase 3b OS... [more]
A0A075A8F61.180e-4930.77Uncharacterized protein (Fragment) OS=Opisthorchis... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
smpdl3b2.449e-4329.21sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a3.005e-4129.23sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
smpdl3b9.000e-3327.78sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpd15.311e-1122.02sphingomyelin phosphodiesterase 1 [Source:ZFIN;Acc... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO312089.198e-2025.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO469932.296e-1625.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO468741.146e-1425.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
smpdl3b8.754e-4428.67sphingomyelin phosphodiesterase acid like 3B [Sour... [more]
smpdl3a1.676e-2927.85sphingomyelin phosphodiesterase acid like 3A [Sour... [more]
smpd16.183e-1123.24sphingomyelin phosphodiesterase 1 [Source:NCBI gen... [more]
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BLAST of Acid sphingomyelinase-like phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000071517.10.000e+099.09SMESG000071517.1[more]
SMESG000078127.14.604e-12344.82SMESG000078127.1[more]
SMESG000024647.11.878e-11245.07SMESG000024647.1[more]
SMESG000024635.15.087e-11043.85SMESG000024635.1[more]
SMESG000055453.18.983e-10141.59SMESG000055453.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000819 ID=SMED30000819|Name=Acid sphingomyelinase-like phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=1598bp
GAAAATTAAACAGTTTCAGCAGTAGTATAAACAATTTATTACAATGCTTT
GCAATTCAATCCACGAACGGTTGAAAATAAACTACGTAATATCAAAGTGG
TTGACATTATATAAGTGATGTGAACTATAGCATTAATGATTTCGTTCATA
TGATCAATAAAATAATTAATAAATAATTAATCAATATTTCGGAATTATTA
TGGTTCAGTTACTTTGGATTTTTCTCGGTGCGCTCTTTCATTTGACCGTT
GGATTCCAAGGATATTTTTGGGATATATGCGATTTACATTTGAACATTTC
CAATCTCAATTACAGCCTTGAAAATTTAGGAAATTATAAATCCGATTCGA
CGATTTTGCTGATGAAGTCGGCGCTGATTGAAATGAAGTCAATTTACAGC
AACCCGGAGTTCATTATTGTCAACGGAGACAACATGTTTCATGGAGATGC
CAAATTCAATGAAACAATTGTAATGGTTAGTAATGAAATTTTTAATATCT
TTTCAAGCGCCATTGTAATTCCAAGCTTGGGCAATCATGACATAATGCCA
CGAAATGTTATCCAAAACTATTCCCCATGGTGCAATGTATGGTATAATAT
TTGGGAAAAGTATTTAAACAATTTGGATCCAGTGGAAATCGAAAATGCCA
AAAAAGGATGTTTCTATTCTCGAACAATTCAGTCAAAGAATGGAAATGTA
CTTGTGGTTGTCCTTAACACTTTGTTGTGGTATACTCGCAATCGTCTAAC
ACTGAATCAGCTTGATCCAAATGATCAATTCAAATGGCTTGAACAAAGAA
TACAATACGCTAAAAATATGAAAATAAAGATATTTCTCGTTGGTCACATA
CCTCCCGGGACATCGGAATATAGCTCAATCATAATTGAACATCTTCATTC
AAATTTCAATTCAAGATTGGTGGACATAATGCAATCAAATTATGAAACGA
TCCATGCCGGTATATTTGCTCACCAACATTCAGACGCCTTCAAAGTTGTT
TACAATAAAACCAATAAACCAGTGGTACCTATCTTTTTGGCTCCTTCTGT
CACACCTTTTCGGCTATCTACCATAGGGTCAGTTAACCCTTCCTTTCGAT
TGTATAAATGGAGTACAACGGCTGAAAACAGTAGCTACGACCAATATCAT
GCAATATTGCCCAGCAGTAATGAAAAACAAATATTGGCATGGACCAAGGA
ATATTCCTCTCTGGAATTTGTACCGGGAATTTCAGCAGGACATTTAGCTA
AATTATTATCGGATTTTGCATCAAAAAATTCCACATATTTCAACAAGTTT
TTCAGTTATCATCTCTCAGGCCAGCCTCATGACAATGCTGCCTGTCCATA
TGATAGCCAGTGTCGACATCAATTTATTTGCTCCATGAAATATGTCGACT
ATCCGGCATTTTATAGTTGTTGGAAACAATATTCGAGAGGGGTCGCACTT
TTGTTCAAAATTGAAATATCTTTAATTCTGAATGTTATTTTGTTCATAAA
ATTATTTTTTCAAGACTCGTAAATTTATTGAGACTTTATTTGGAGATTAA
CTTTTATTTCATTTTTTAATTTAATTTCAATAATAAATTAAAATTGTA
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protein sequence of SMED30000819-orf-1

>SMED30000819-orf-1 ID=SMED30000819-orf-1|Name=SMED30000819-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=441bp
MVQLLWIFLGALFHLTVGFQGYFWDICDLHLNISNLNYSLENLGNYKSDS
TILLMKSALIEMKSIYSNPEFIIVNGDNMFHGDAKFNETIVMVSNEIFNI
FSSAIVIPSLGNHDIMPRNVIQNYSPWCNVWYNIWEKYLNNLDPVEIENA
KKGCFYSRTIQSKNGNVLVVVLNTLLWYTRNRLTLNQLDPNDQFKWLEQR
IQYAKNMKIKIFLVGHIPPGTSEYSSIIIEHLHSNFNSRLVDIMQSNYET
IHAGIFAHQHSDAFKVVYNKTNKPVVPIFLAPSVTPFRLSTIGSVNPSFR
LYKWSTTAENSSYDQYHAILPSSNEKQILAWTKEYSSLEFVPGISAGHLA
KLLSDFASKNSTYFNKFFSYHLSGQPHDNAACPYDSQCRHQFICSMKYVD
YPAFYSCWKQYSRGVALLFKIEISLILNVILFIKLFFQDS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0004767sphingomyelin phosphodiesterase activity
GO:0008081phosphoric diester hydrolase activity
GO:0008270zinc ion binding
GO:0046872metal ion binding
GO:0016787hydrolase activity
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
GO:0005615extracellular space
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006685sphingomyelin catabolic process
GO:0034122negative regulation of toll-like receptor signaling pathway
GO:0046466membrane lipid catabolic process
GO:0050728negative regulation of inflammatory response
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR029052Metallo-depent_PP-like
IPR004843Calcineurin-like_PHP_ApaH
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR029052Metallo-dependent phosphatase-likeGENE3DG3DSA:3.60.21.10coord: 38..280
e-value: 1.7E-7
score: 33.1
NoneNo IPR availablePANTHERPTHR10340SPHINGOMYELIN PHOSPHODIESTERASEcoord: 12..419
NoneNo IPR availablePANTHERPTHR10340:SF13SPHINGOMYELINASE PHOSPHODIESTERASE Ccoord: 12..419
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.899
NoneNo IPR availableSUPERFAMILYSSF56300Metallo-dependent phosphatasescoord: 23..305
NoneNo IPR availableTMHMMTMhelixcoord: 5..24