Nicotinamide-nucleotide adenylyltransferase

Overview
NameNicotinamide-nucleotide adenylyltransferase
Smed IDSMED30000801
Length (bp)1134
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Nicotinamide-nucleotide adenylyltransferase (SMED30000801) t-SNE clustered cells

Violin plots show distribution of expression levels for Nicotinamide-nucleotide adenylyltransferase (SMED30000801) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Nicotinamide-nucleotide adenylyltransferase (SMED30000801) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Nicotinamide-nucleotide adenylyltransferase (SMED30000801) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000801

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymal cellSMED30000801SMESG000055048.1 dd_Smed_v4_5656_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000801SMESG000008616.1 SMESG000004485.1 Contig4906GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000801SMESG000055048.1 Contig4906GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Match: NMNAT1 (nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877])

HSP 1 Score: 238.424 bits (607), Expect = 2.689e-76
Identity = 119/255 (46.67%), Postives = 163/255 (63.92%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKIT----------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    V+ GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L     D  QN P+  +  +       +KW E  D SQK +          +KLLCGADL+ESFAVP LW   DI  I+ ++GL+ ++R   + +KFIYESD L+K + NI ++  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++NLY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTLERPGR------KRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLY 254
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Match: NMNAT1 (nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877])

HSP 1 Score: 238.424 bits (607), Expect = 2.689e-76
Identity = 119/255 (46.67%), Postives = 163/255 (63.92%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKIT----------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    V+ GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L     D  QN P+  +  +       +KW E  D SQK +          +KLLCGADL+ESFAVP LW   DI  I+ ++GL+ ++R   + +KFIYESD L+K + NI ++  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++NLY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTLERPGR------KRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLY 254
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Match: NMNAT3 (nicotinamide nucleotide adenylyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:20989])

HSP 1 Score: 187.578 bits (475), Expect = 7.675e-57
Identity = 101/245 (41.22%), Postives = 139/245 (56.73%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            R  ++LL CGSFNPITNMHLRMFE+A+DH   +   +VI GIISPVND YGK+ L  S  R  M +LA+    ++ +D WE  Q +W  T  VL                +H    +S   + G    K + +   +    +KLLCGAD++++F  P LW D  I  I+E  GLV + R   + + +I ES  L   + NI L    +  +IS+T IRR+L + QSVKYLIPD V+ YIK++ LY
Sbjct:    4 RIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLR--------------HHHSKLLRSPPQMEGPDHGKALFSTPAAVP-ELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 233
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Match: NMNAT2 (nicotinamide nucleotide adenylyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16789])

HSP 1 Score: 145.591 bits (366), Expect = 4.025e-40
Identity = 102/298 (34.23%), Postives = 152/298 (51.01%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE---------------------YQNHPSATK--SAKTLNGISS------------KKWI---ENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIG---TDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H++MFE A+D+   +    VIGGI+SPV+D+YGKQGL  S  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                        YQN   ATK  +AK L  +              +++    EN +L         ++ I LLCG+DL+ESF +PGLW++ D+  I+   G+VV+ R+  + ++ +  S  L K+K NI ++ + I    + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:    6 KTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYL-SQPVIDYILKSQLY 302
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Match: NMNAT3 (nicotinamide nucleotide adenylyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:20989])

HSP 1 Score: 135.961 bits (341), Expect = 2.076e-37
Identity = 79/209 (37.80%), Postives = 112/209 (53.59%), Query Frame = 3 
Query:  210 EVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +VI GIISPVND YGK+ L  S  R  M +LA+    ++ +D WE  Q +W  T  VL                +H    +S   + G    K + +   +    +KLLCGAD++++F  P LW D  I  I+E  GLV + R   + + +I ES  L   + NI L    +  +IS+T IRR+L + QSVKYLIPD V+ YIK++ LY
Sbjct:    3 QVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLR--------------HHHSKLLRSPPQMEGPDHGKALFSTPAAVP-ELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 196
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Celegans
Match: nmat-2 (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [Source:UniProtKB/Swiss-Prot;Acc:P91851])

HSP 1 Score: 117.857 bits (294), Expect = 4.931e-31
Identity = 80/253 (31.62%), Postives = 127/253 (50.20%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYG-KQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFA--VP---GLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIG-TDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDI 845
            ++ LL  GSFNP T  HLRM E+A+ H  ++  ++V+ GI+SPV D+Y  K  L  S  R +M++ A     ++  D+WE ++  W RT  VL     R   +L  E                               + + L+ G D+V+SF   +P    LW+ +DI  I+   GL+V+SRE  N    I     + +F   I  + + +  + +SST++R ++  K+S+KY  PD V+ +I+ENNLY  I
Sbjct:    3 RVALLAVGSFNPPTIAHLRMLEVARSHL-ETINTQVVEGIMSPVADSYNNKPTLIKSNFRIQMVRAATKSSDWIRADDWECTRTTWTRTIDVL-----RHHRELVQE--------------------------KFGSDVGMMLVVGGDVVDSFTRILPDGSNLWNSSDIRTIITEFGLIVLSREGSNPLNTIQSMPAISEFCDRIIQVKDEVCPSGVSSTRLRAAIMNKKSIKYSTPDEVINFIRENNLYQKI 223
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Celegans
Match: nmat-1 (Nicotinamide-nucleotide adenylyltransferase [Source:UniProtKB/TrEMBL;Acc:Q9XXM2])

HSP 1 Score: 91.6633 bits (226), Expect = 2.250e-21
Identity = 78/255 (30.59%), Postives = 119/255 (46.67%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESF------AVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYE------SDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            K+++L  GSFNP TN HL M E AK +  + S   V+ GI+SPV+D Y K+ L  +  R    + A     ++    WE +Q +W  T  VL+  ++ + N                                L   + + LL G D++ESF        P +WD  D+  I+   G+VV SR   + E+ + +      SDK++ F KN           ISST +R +L   +S+KY  PD V++YIK++ LY
Sbjct:    5 KVVILAVGSFNPPTNGHLCMMEDAK-YSLEKSGKIVLEGIMSPVSDGYAKKSLISAKHRLAQTEAATYDSDWIHASGWECAQSEWTATVNVLKHHQQDVKN-------------------------------KLGSDVNVLLLFGGDVIESFDKFYADGTP-VWDREDVEEIIS-AGIVVRSRPGSDPEQTLKKLNLNENSDKVH-FIKNAISS-----NSISSTSLRAALKEHRSIKYTTPDSVIKYIKDHRLY 219
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Fly
Match: Nmnat (gene:FBgn0039254 transcript:FBtr0473366)

HSP 1 Score: 224.172 bits (570), Expect = 3.829e-71
Identity = 120/260 (46.15%), Postives = 158/260 (60.77%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN--IDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS*RVFIFKSIEA 881
            +I  + CG F+P T MHLRMFE+AKDHF    T  V+GGIISP +D+YGK+GL  +  RC M+KLA     ++ + +WEV Q +W RT+ VL+  +  + N +        S               W+     D    + +KLLCGADL+ESFAVPGLW + DI  I+ +HGLVVI+R   N  KFI++SD L K++ NI LI NW+  ++SST IRR L R QSVKYL+ DLVLEYIK          R+F FKS +A
Sbjct:   14 RIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHI-------NSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQ--------RLFNFKSRDA 258
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Fly
Match: Nmnat (gene:FBgn0039254 transcript:FBtr0084750)

HSP 1 Score: 223.402 bits (568), Expect = 1.583e-70
Identity = 120/260 (46.15%), Postives = 158/260 (60.77%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN--IDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS*RVFIFKSIEA 881
            +I  + CG F+P T MHLRMFE+AKDHF    T  V+GGIISP +D+YGK+GL  +  RC M+KLA     ++ + +WEV Q +W RT+ VL+  +  + N +        S               W+     D    + +KLLCGADL+ESFAVPGLW + DI  I+ +HGLVVI+R   N  KFI++SD L K++ NI LI NW+  ++SST IRR L R QSVKYL+ DLVLEYIK          R+F FKS +A
Sbjct:   45 RIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHI-------NSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQ--------RLFNFKSRDA 289
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Fly
Match: Nmnat (gene:FBgn0039254 transcript:FBtr0337012)

HSP 1 Score: 224.172 bits (570), Expect = 6.603e-70
Identity = 115/245 (46.94%), Postives = 152/245 (62.04%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN--IDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +I  + CG F+P T MHLRMFE+AKDHF    T  V+GGIISP +D+YGK+GL  +  RC M+KLA     ++ + +WEV Q +W RT+ VL+  +  + N +        S               W+     D    + +KLLCGADL+ESFAVPGLW + DI  I+ +HGLVVI+R   N  KFI++SD L K++ NI LI NW+  ++SST IRR L R QSVKYL+ DLVLEYIK   L+
Sbjct:   14 RIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHI-------NSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLF 251
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Fly
Match: Nmnat (gene:FBgn0039254 transcript:FBtr0084749)

HSP 1 Score: 223.787 bits (569), Expect = 1.986e-69
Identity = 115/245 (46.94%), Postives = 152/245 (62.04%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN--IDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +I  + CG F+P T MHLRMFE+AKDHF    T  V+GGIISP +D+YGK+GL  +  RC M+KLA     ++ + +WEV Q +W RT+ VL+  +  + N +        S               W+     D    + +KLLCGADL+ESFAVPGLW + DI  I+ +HGLVVI+R   N  KFI++SD L K++ NI LI NW+  ++SST IRR L R QSVKYL+ DLVLEYIK   L+
Sbjct:   45 RIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHI-------NSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLF 282
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:ZFIN;Acc:ZDB-GENE-050417-101])

HSP 1 Score: 209.149 bits (531), Expect = 4.322e-65
Identity = 106/256 (41.41%), Postives = 155/256 (60.55%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNG--ISSKKWIENIDLSQKIT-----------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            K++LL CGSFNPITNMHLRMFELA+DH  D+   +V+ GIISPV D Y K+GL  +  R +M +LA     ++ +D+WE  QP+W  T  V+               ++H +   S  + NG  + + K+ +   + +K             + LLCGAD++ESF VP LW   DI  I+  +G+  I+R   + EKFI +SD LYK +KNI ++  W+  +IS+T IRR+L R QSV+YL+PD V+ YI++++LY
Sbjct:    8 KLVLLACGSFNPITNMHLRMFELARDHLEDTGRYKVVKGIISPVGDGYKKKGLIEACHRLEMARLATESSEWITVDDWESQQPEWVETAKVV---------------RHHHAVLSSENSSNGDNVDTGKYRKRRKMEKKSPSCMNPKADHSHLNLLCGADVLESFGVPNLWKPEDIEEIVGRYGVTCITRCGSDAEKFINQSDVLYKHRKNISVVREWVTNEISATHIRRALRRGQSVRYLLPDSVVRYIQDHSLY 248
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:ZFIN;Acc:ZDB-GENE-050417-101])

HSP 1 Score: 209.149 bits (531), Expect = 4.322e-65
Identity = 106/256 (41.41%), Postives = 155/256 (60.55%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNG--ISSKKWIENIDLSQKIT-----------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            K++LL CGSFNPITNMHLRMFELA+DH  D+   +V+ GIISPV D Y K+GL  +  R +M +LA     ++ +D+WE  QP+W  T  V+               ++H +   S  + NG  + + K+ +   + +K             + LLCGAD++ESF VP LW   DI  I+  +G+  I+R   + EKFI +SD LYK +KNI ++  W+  +IS+T IRR+L R QSV+YL+PD V+ YI++++LY
Sbjct:    8 KLVLLACGSFNPITNMHLRMFELARDHLEDTGRYKVVKGIISPVGDGYKKKGLIEACHRLEMARLATESSEWITVDDWESQQPEWVETAKVV---------------RHHHAVLSSENSSNGDNVDTGKYRKRRKMEKKSPSCMNPKADHSHLNLLCGADVLESFGVPNLWKPEDIEEIVGRYGVTCITRCGSDAEKFINQSDVLYKHRKNISVVREWVTNEISATHIRRALRRGQSVRYLLPDSVVRYIQDHSLY 248
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:ZFIN;Acc:ZDB-GENE-070912-331])

HSP 1 Score: 201.83 bits (512), Expect = 1.185e-62
Identity = 104/245 (42.45%), Postives = 144/245 (58.78%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            R  ++LL CGSFNPIT+ H+R+FELA+DH   +    V+GGIISPV D YGKQGL  S  R  M +LA+    ++ +D+WE  QP W  T V +     R+               K   T +           D+ Q   +KLLCGAD ++SF VPGLW D  I  ++   GLV +SR +   ++ I+ESD L K + +I L+  W+  +IS+T+IRR+L R  SVKYL+PD V+EYI+E+ LY
Sbjct:    4 RIPLVLLACGSFNPITHQHMRLFELARDHMHQTGLYRVVGGIISPVGDGYGKQGLVASKHRLAMARLALQSSDWVSVDDWESQQPDWTETVVTMRYHYGRVAAQ--------HCCNKGPPTTS-----------DVPQ---LKLLCGADFMDSFKVPGLWTDEHIEEVVGRFGLVCVSRGSLQPDRAIHESDLLSKHRPSIFLVREWVHNEISATEIRRALRRGHSVKYLLPDSVIEYIREHKLY 226
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Match: nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:NCBI gene;Acc:336257])

HSP 1 Score: 145.976 bits (367), Expect = 1.759e-40
Identity = 99/295 (33.56%), Postives = 146/295 (49.49%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFD------------EYQNHPSATKSAKTLNGISSKKWI-----------------------ENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIG---TDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H+ MFE A+++   +    VIGGI+SPV+D+YGK GL PS  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +              + QN  SA         ++ K W                        EN +L         ++ I LLCG+DL+ESF +PGLW+++D+  I+   G+VV+ R+  + E+ +  S  L K K NI ++ + I    + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:    6 KTHVILLSCGSFNPITKGHIHMFEKAREYLHKTGRFIVIGGIVSPVHDSYGKPGLVPSRHRLTMCQLAVQSSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSTTPVIGQPQNETSAIYQNTVNKSVAIKFWGKMSESLGKICCVRPHMDRFTFVDENANLGTAMRYEEIELRILLLCGSDLLESFCIPGLWNESDMEVIVGDFGIVVVPRDGADTERIMNHSSVLRKHKDNIIVVKDEIDHTMSIVSSTKSRLALQHGDGHVVDYL-SQPVIDYILQSQLY 299
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:ZFIN;Acc:ZDB-GENE-070912-331])

HSP 1 Score: 122.865 bits (307), Expect = 4.757e-33
Identity = 66/182 (36.26%), Postives = 98/182 (53.85%), Query Frame = 3 
Query:  291 MIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            M +LA+    ++ +D+WE  QP W  T V +     R+               K   T + +                +KLLCGAD ++SF VPGLW D  I  ++   GLV +SR +   ++ I+ESD L K + +I L+  W+  +IS+T+IRR+L R  SVKYL+PD V+EYI+E+ LY
Sbjct:    1 MARLALQSSDWVSVDDWESQQPDWTETVVTMRYHYGRV--------AAQHCCNKGPPTTSDVPQ--------------LKLLCGADFMDSFKVPGLWTDEHIEEVVGRFGLVCVSRGSLQPDRAIHESDLLSKHRPSIFLVREWVHNEISATEIRRALRRGHSVKYLLPDSVIEYIREHKLY 160
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Xenopus
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:NCBI gene;Acc:549526])

HSP 1 Score: 201.83 bits (512), Expect = 1.173e-61
Identity = 106/251 (42.23%), Postives = 150/251 (59.76%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKI--TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 848
            R +++LL  GSFNPIT MHLR+FELA+D+  ++   +VI GIISPV D Y K+GL  +  R  M  LA     ++ +D+WE SQ +W  T +VL   +++L N    +        K  K     S +   +      K+   +KLLCGAD++ES   P LW + D+  I+   G+V I+R   N   FIYESD L+K+K  I L+  WI  DISSTKIRR+L R  S++YL+PD V+EYI+ + LY++ S
Sbjct:   36 RREVVLLATGSFNPITVMHLRLFELARDYLHETGKYKVIKGIISPVGDGYKKKGLIEASHRLAMANLATKNSNWIEVDSWECSQKEWMETVLVLRHHQQKLANANTSDSSEKVVHKKGHKRKRENSYQDKTDRCLQESKVMPQVKLLCGADMLESLGKPNLWKNEDVIEILSSFGIVCITRLGSNASNFIYESDILWKYKHMIHLVEEWITNDISSTKIRRALRRGMSIRYLVPDSVVEYIENHELYNERS 286
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Xenopus
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:NCBI gene;Acc:549526])

HSP 1 Score: 201.06 bits (510), Expect = 2.824e-61
Identity = 106/251 (42.23%), Postives = 150/251 (59.76%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKI--TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 848
            R +++LL  GSFNPIT MHLR+FELA+D+  ++   +VI GIISPV D Y K+GL  +  R  M  LA     ++ +D+WE SQ +W  T +VL   +++L N    +        K  K     S +   +      K+   +KLLCGAD++ES   P LW + D+  I+   G+V I+R   N   FIYESD L+K+K  I L+  WI  DISSTKIRR+L R  S++YL+PD V+EYI+ + LY++ S
Sbjct:   51 RREVVLLATGSFNPITVMHLRLFELARDYLHETGKYKVIKGIISPVGDGYKKKGLIEASHRLAMANLATKNSNWIEVDSWECSQKEWMETVLVLRHHQQKLANANTSDSSEKVVHKKGHKRKRENSYQDKTDRCLQESKVMPQVKLLCGADMLESLGKPNLWKNEDVIEILSSFGIVCITRLGSNASNFIYESDILWKYKHMIHLVEEWITNDISSTKIRRALRRGMSIRYLVPDSVVEYIENHELYNERS 301
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Xenopus
Match: hmgxb3 (HMG-box containing 3 [Source:Xenbase;Acc:XB-GENE-989732])

HSP 1 Score: 145.976 bits (367), Expect = 2.928e-40
Identity = 105/304 (34.54%), Postives = 150/304 (49.34%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDEYQNHPSATKS-AKTLNGISSKKWIENIDLSQKIT----------------------------------------------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLI---PNWIGTDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLYHDIS 848
            +  +ILL CGSFNPIT  H++MFE A+D+   +    VIGGIISPV+D+YGKQGL  S  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +     N PS T    ++LN  S++   +N +LS K T                                              I LLCG+DL+ESF +PGLW+++D+  I+   G+VV+ R++   E+ I  S  L K+K NI  +    N     +SSTK R +L       V YL    V++Y+ ++ LY + S
Sbjct:    6 KTHVILLACGSFNPITKGHIQMFERARDYLHKTGKFIVIGGIISPVHDSYGKQGLVSSRHRLNMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNV-NTPSVTPVIGQSLNQ-STQPVYQNSNLSNKPTAVRILGKVGEGLSRMCCVRPNLQRVTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNESDMEVIVGDFGIVVVPRDSVEPEQIINHSSLLRKYKNNILTVKDDSNHPMAVVSSTKSRLALQHGDGHVVDYL-AQPVIDYVLKSQLYINTS 306
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Match: Nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:MGI Symbol;Acc:MGI:1913704])

HSP 1 Score: 218.394 bits (555), Expect = 1.806e-68
Identity = 116/256 (45.31%), Postives = 158/256 (61.72%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLS--QKIT---------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    VI GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L        Q+ P+  K  +       +KW +    S  QK           +KLLCGADL+ESF+VP LW   DI  I+ + GL+ I+R   + +KFIYESD L++ + NI L+  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++ LY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGR------KRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELY 255
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Match: Nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:MGI Symbol;Acc:MGI:1913704])

HSP 1 Score: 218.394 bits (555), Expect = 1.806e-68
Identity = 116/256 (45.31%), Postives = 158/256 (61.72%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLS--QKIT---------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    VI GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L        Q+ P+  K  +       +KW +    S  QK           +KLLCGADL+ESF+VP LW   DI  I+ + GL+ I+R   + +KFIYESD L++ + NI L+  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++ LY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGR------KRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELY 255
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Match: Nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:MGI Symbol;Acc:MGI:1921330])

HSP 1 Score: 187.963 bits (476), Expect = 2.873e-57
Identity = 101/248 (40.73%), Postives = 144/248 (58.06%), Query Frame = 3 
Query:   99 MRNKI--ILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            M+N+I  +LL CGSFNPITNMHLR+FE+A+DH   +   +VI GIISPVND+YGK+ L  S  R  M +LA+    ++ +D WE  Q +W  T  VL    + L           PS T SA                 +    +KLLCGAD++++F  P LW D  I  I+E  GLV +SR   + E++I +S  L +F+ NI L    +  +IS+T +R++L + QSVKYL+P+ V+ YI++  LY
Sbjct:    1 MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGRYQVIEGIISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHRELLRSSAQMDGPDPSKTPSAS----------------AALPELKLLCGADVLKTFQTPNLWKDTHIQEIVEKFGLVCVSRSGHDPERYISDSPILQQFQHNIHLAREPVLNEISATYVRKALGQGQSVKYLLPEAVITYIRDQGLY 232
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Match: Nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:MGI Symbol;Acc:MGI:2444155])

HSP 1 Score: 144.436 bits (363), Expect = 7.955e-40
Identity = 100/298 (33.56%), Postives = 151/298 (50.67%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE---------------------YQNH--PSATKSAKTLNGISS------------KKWI---ENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIG---TDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H++MFE A+D+   +    VIGGI+SPV+D+YGKQGL  S  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                        YQN   P+   +AK L  +              +++    EN +L         ++ I LLCG+DL+ESF +PGLW++ D+  I+   G+VV+ R+  + ++ +  S  L K+K NI ++ + I    + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:    6 KTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQHENTQPIYQNSNVPTKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYL-SQPVIDYILKSQLY 302
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Match: Nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:MGI Symbol;Acc:MGI:2444155])

HSP 1 Score: 137.887 bits (346), Expect = 1.069e-37
Identity = 91/273 (33.33%), Postives = 138/273 (50.55%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE---------------------YQNH--PSATKSAKTLNGISS------------KKWI---ENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIG---TDISSTKIRRSLS 767
            +  +ILL CGSFNPIT  H++MFE A+D+   +    VIGGI+SPV+D+YGKQGL  S  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                        YQN   P+   +AK L  +              +++    EN +L         ++ I LLCG+DL+ESF +PGLW++ D+  I+   G+VV+ R+  + ++ +  S  L K+K NI ++ + I    + +SSTK  +  S
Sbjct:    6 KTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQHENTQPIYQNSNVPTKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSSQGFS 278
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Match: sp|Q9HAN9|NMNA1_HUMAN (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Homo sapiens OX=9606 GN=NMNAT1 PE=1 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 1.291e-75
Identity = 119/255 (46.67%), Postives = 163/255 (63.92%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKIT----------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    V+ GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L     D  QN P+  +  +       +KW E  D SQK +          +KLLCGADL+ESFAVP LW   DI  I+ ++GL+ ++R   + +KFIYESD L+K + NI ++  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++NLY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTLERPGR------KRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLY 254
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Match: sp|Q0VD50|NMNA1_BOVIN (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Bos taurus OX=9913 GN=NMNAT1 PE=2 SV=1)

HSP 1 Score: 231.876 bits (590), Expect = 6.445e-73
Identity = 119/251 (47.41%), Postives = 158/251 (62.95%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKS------AKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +   +VI GIISPV DAY K+GL  +  R  M +LA     ++ +D WE  Q +W  T  VL   +++L   + D  QN P   K       A+    IS KK +E         +KLLCGAD +ESF VP LW   DI  I+  +GL+ I+R   + +KFIYESD L+K + NI L+  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++NLY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGKYKVIKGIISPVGDAYKKKGLISAYHRVIMAELATKNSKWVEVDTWESLQKEWTETAKVLRHHQEKLEASICDPQQNSPVLEKPGRKRKWAEQKQDISEKKSLEQTKTKGVPKVKLLCGADFLESFGVPNLWKSEDITKILGDYGLICITRAGNDAQKFIYESDVLWKHQNNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVEEYIEKHNLY 256
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Match: sp|Q9EPA7|NMNA1_MOUSE (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Mus musculus OX=10090 GN=Nmnat1 PE=1 SV=2)

HSP 1 Score: 218.394 bits (555), Expect = 1.263e-67
Identity = 116/256 (45.31%), Postives = 158/256 (61.72%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLS--QKIT---------IKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + +++LL CGSFNPITNMHLR+FELAKD+   +    VI GIISPV DAY K+GL P+  R  M +LA     ++ +D WE  Q +W  T  VL   +++L        Q+ P+  K  +       +KW +    S  QK           +KLLCGADL+ESF+VP LW   DI  I+ + GL+ I+R   + +KFIYESD L++ + NI L+  WI  DISSTKIRR+L R QS++YL+PDLV EYI+++ LY
Sbjct:    6 KTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGR------KRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELY 255
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Match: sp|Q99JR6|NMNA3_MOUSE (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Mus musculus OX=10090 GN=Nmnat3 PE=1 SV=1)

HSP 1 Score: 187.963 bits (476), Expect = 2.009e-56
Identity = 101/248 (40.73%), Postives = 144/248 (58.06%), Query Frame = 3 
Query:   99 MRNKI--ILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            M+N+I  +LL CGSFNPITNMHLR+FE+A+DH   +   +VI GIISPVND+YGK+ L  S  R  M +LA+    ++ +D WE  Q +W  T  VL    + L           PS T SA                 +    +KLLCGAD++++F  P LW D  I  I+E  GLV +SR   + E++I +S  L +F+ NI L    +  +IS+T +R++L + QSVKYL+P+ V+ YI++  LY
Sbjct:    1 MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGRYQVIEGIISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHRELLRSSAQMDGPDPSKTPSAS----------------AALPELKLLCGADVLKTFQTPNLWKDTHIQEIVEKFGLVCVSRSGHDPERYISDSPILQQFQHNIHLAREPVLNEISATYVRKALGQGQSVKYLLPEAVITYIRDQGLY 232
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Match: sp|Q96T66|NMNA3_HUMAN (Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Homo sapiens OX=9606 GN=NMNAT3 PE=1 SV=2)

HSP 1 Score: 187.578 bits (475), Expect = 3.686e-56
Identity = 101/245 (41.22%), Postives = 139/245 (56.73%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            R  ++LL CGSFNPITNMHLRMFE+A+DH   +   +VI GIISPVND YGK+ L  S  R  M +LA+    ++ +D WE  Q +W  T  VL                +H    +S   + G    K + +   +    +KLLCGAD++++F  P LW D  I  I+E  GLV + R   + + +I ES  L   + NI L    +  +IS+T IRR+L + QSVKYLIPD V+ YIK++ LY
Sbjct:    4 RIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLR--------------HHHSKLLRSPPQMEGPDHGKALFSTPAAVP-ELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 233
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Match: D3TNV9 (Nicotinamide-nucleotide adenylyltransferase (Fragment) OS=Glossina morsitans morsitans OX=37546 PE=2 SV=1)

HSP 1 Score: 245.358 bits (625), Expect = 9.205e-76
Identity = 119/246 (48.37%), Postives = 168/246 (68.29%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQK--ITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYH 839
            +I+L+ CGSF+P T MHLRMFE+AKDHF  + T +VIGGI+SP +D+YGK+GL  +  RC MIKLA+    ++ + +WE  Q  W+RT+ VL+  +     +  + Y N P    +    + +    W+ N    +K  + +KLLCGAD++ESFAVPGLW D DI  I+ HHGLVVI+R   N E+FI++SD L K+++NI L+ NW+  D+SST IRR L+R QSVKYLI D+V+EYI++N L+ 
Sbjct:   15 RIVLIACGSFSPPTPMHLRMFEIAKDHFEVNGTHKVIGGIVSPTHDSYGKKGLAAAKHRCAMIKLALQSSSWIRLSDWETQQDGWSRTKSVLQYHQ-----NFMNNYINSPDVNTTMSGDDCLPG--WLPNNLRVRKDPVQLKLLCGADMLESFAVPGLWSDADIEDIVAHHGLVVITRSGANPERFIFDSDVLTKYQRNITLVTNWVPNDVSSTVIRRLLARGQSVKYLINDMVIEYIRQNGLFQ 253
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Match: A0A1A9X1T8 (Nicotinamide-nucleotide adenylyltransferase OS=Glossina brevipalpis OX=37001 PE=3 SV=1)

HSP 1 Score: 243.047 bits (619), Expect = 3.533e-75
Identity = 119/244 (48.77%), Postives = 164/244 (67.21%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYH 839
            +I+L+ CGSF+P T MHLRMFE+AKDHF  + T +VIGGI+SP +D YGK+GL P+  RC MIKLA+    ++ + +WE  Q  W+RT+ VL+  +     +  + Y N P    +    + + S    +  D    + +KLLCGADL+ESFAVPGLW D DI  I+ HHGLVVISR   N E+FI++SD L  +++NI L+ NW+  D+SST IR+ L+R QSVKYLI D+V+EYI +N L+ 
Sbjct:   15 RIVLIACGSFSPPTPMHLRMFEIAKDHFEMNGTCKVIGGIVSPTHDDYGKKGLAPAKHRCAMIKLALQSSSWIRLSDWETQQNGWSRTKSVLQYHQ-----NFMNNYINSPDIKTNMNGGDCLPSWLPPDLHDRKDPVQLKLLCGADLLESFAVPGLWSDADIEDIVAHHGLVVISRSGANPERFIFDSDILTTYQRNITLVINWVPNDVSSTVIRKLLARGQSVKYLINDMVIEYITQNGLFQ 253
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Match: A0A4D5RX40 (Nicotinamide-nucleotide adenylyltransferase (Fragment) OS=Ixodes scapularis OX=6945 PE=3 SV=1)

HSP 1 Score: 241.891 bits (616), Expect = 1.637e-74
Identity = 116/251 (46.22%), Postives = 164/251 (65.34%), Query Frame = 3 
Query:   99 MRNKIILLLCGSFNPITNMHLRMFELAKDHFRD--SSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDL---SQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            MR + +L+ CGSFNP+TNMHLRMFELA+DH ++  S   EVIGG++SPV+DAYGK GL  +  RC M+ LA+  + ++ +D WE SQ  W  TR VL+     L           P   +    LNG S   W +++ +   +  + + LLCGADL++SF+VPGLW D DI +++   GLVV++R  C+  +FIYE+D LY+ + NI L+  W+  DISST IRR+L+R +SVKYL+ D V+ YI+E+ LY
Sbjct:    1 MRKRTVLVACGSFNPVTNMHLRMFELARDHLQNGISPPVEVIGGLVSPVSDAYGKAGLVSARHRCAMLNLALLTNDWVRLDTWECSQEGWTETRRVLQHHLDALRESHQHRVDGAPHKRRRTDNLNG-SDGSWRDSMPVLAEASPVGVMLLCGADLLQSFSVPGLWKDADIEHLVSQFGLVVVTRSGCDAARFIYETDCLYRNRHNIHLVTEWMTNDISSTGIRRALARGESVKYLLQDSVITYIQEHGLY 250
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Match: A0A1A9Y7D2 (Nicotinamide-nucleotide adenylyltransferase OS=Glossina fuscipes fuscipes OX=201502 PE=3 SV=1)

HSP 1 Score: 245.358 bits (625), Expect = 2.247e-74
Identity = 117/246 (47.56%), Postives = 168/246 (68.29%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWI-ENIDLSQK-ITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYH 839
            +I+L+ CGSF+P T MHLRMFE+AKDHF  + T +V+GGI+SP +D YGK+GL  +  RC MIKLA+    ++ + +WE  Q  W+RT+ VL+  +     +  + Y N P  T +    + +    W+  N+ + +  + +KLLCGAD++ESF VPGLW D DI  I+ HHGLVV++R   N EKFI++SD L K+++NI L+ NW+  D+SST IRR L+R QSVKYLI D+V+EYI++N L+ 
Sbjct:   15 RIVLIACGSFSPPTPMHLRMFEIAKDHFEVNGTHKVVGGIVSPTHDGYGKKGLAAAKHRCAMIKLALQSSSWIRLSDWETQQDGWSRTKSVLQYHQ-----NFMNNYINSPDVTATMSGYDCLPG--WLPANLRVRKDPVQLKLLCGADMLESFGVPGLWSDADIEDIVAHHGLVVVTRSGANPEKFIFDSDVLTKYQRNITLVINWVPNDVSSTVIRRLLARGQSVKYLINDMVIEYIRQNGLFQ 253
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Match: A0A1B0BDE5 (Nicotinamide-nucleotide adenylyltransferase OS=Glossina palpalis gambiensis OX=67801 PE=3 SV=1)

HSP 1 Score: 244.973 bits (624), Expect = 2.503e-74
Identity = 117/246 (47.56%), Postives = 168/246 (68.29%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWI-ENIDLSQK-ITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYH 839
            +I+L+ CGSF+P T MHLRMFE+AKDHF  + T +V+GGI+SP +D YGK+GL  +  RC MIKLA+    ++ + +WE  Q  W+RT+ VL+  +     +  + Y N P  T +    + +    W+  N+ + +  + +KLLCGAD++ESF VPGLW D DI  I+ HHGLVV++R   N EKFI++SD L K+++NI L+ NW+  D+SST IRR L+R QSVKYLI D+V+EYI++N L+ 
Sbjct:   15 RIVLIACGSFSPPTPMHLRMFEIAKDHFEINGTHKVVGGIVSPTHDGYGKKGLAAAKHRCAMIKLALQSSSWIRLSDWETQQDGWSRTKSVLQYHQ-----NFMNNYINSPDVTATMSGYDCLPG--WLPANLRVRKDPVQLKLLCGADMLESFGVPGLWSDADIEDIVAHHGLVVVTRSGANPEKFIFDSDVLTKYQRNITLVINWVPNDVSSTVIRRLLARGQSVKYLINDMVIEYIRQNGLFQ 253
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:ZFIN;Acc:ZDB-GENE-050417-101])

HSP 1 Score: 219.935 bits (559), Expect = 2.098e-69
Identity = 108/255 (42.35%), Postives = 157/255 (61.57%), Query Frame = 3 
Query:   96 EMRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKI--------TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            + + K++LL CGSFNP+TNMHLRMFELA+DH  D+    V+ GIISPV DAY K+GL  +  R +M K A     ++ +D+WE  Q +W  T  V+    +   ++L    QN       A T+  +  ++  EN D              +KLLCGAD++ESF+VP LW   DI  I+  +GLV ++R  C+ EKF+ +SD L++ +KNI ++  W+  DIS+T +RRSL R +SV+YL+PD VL+YI++  LY
Sbjct:    4 QQKTKVVLLACGSFNPVTNMHLRMFELARDHLEDTGKYRVVRGIISPVGDAYKKKGLIEACHRVEMAKQATENSSWITVDDWESQQAEWVETAKVV----RHHHSELLSAEQN----VDEADTVKTVKRRRVEENEDACSSADHNRPGAPELKLLCGADVLESFSVPNLWKPEDIEEIVGRYGLVCVTRGGCDAEKFVNQSDVLFQHRKNIHIVREWVTNDISATHVRRSLRRGRSVRYLLPDRVLDYIQDRCLY 250
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:NCBI gene;Acc:103046673])

HSP 1 Score: 203.371 bits (516), Expect = 3.500e-63
Identity = 105/249 (42.17%), Postives = 148/249 (59.44%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 848
            R  +ILL CGSFNPIT  H+R+FELA+DH   +   +V+GGI+SPV D Y KQGL  S  R  M +LA+    ++ +D+WE  Q  W  T V +    +   N + ++      AT   +TL    S+             +KLLCGAD +E+F VPGLW D  I  ++   GLV +SR     E+ ++E D L+K K+NI L+  WI  +IS+T++RR+L R  SVK+LIPD V++YI+E+NLY   S
Sbjct:    4 RIPLILLACGSFNPITYQHMRLFELARDHMHQTGLYQVVGGIVSPVGDEYAKQGLVSSQHRLAMARLALQSSDWVTVDDWESRQADWTETVVTM----RYHHNCMVEKCWPSTKATPPEQTLASGPSQ-------------LKLLCGADFLETFKVPGLWADEHIEEVVGRFGLVCVSRGGLQPERTVHECDLLHKHKRNIFLVREWIRNEISATEVRRALRRGLSVKFLIPDNVIDYIREHNLYTPTS 235
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Match: nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:NCBI gene;Acc:103023112])

HSP 1 Score: 141.739 bits (356), Expect = 6.615e-39
Identity = 101/297 (34.01%), Postives = 147/297 (49.49%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE--------------------YQNHPSATKS---------AKTLNGISSKK--------WIENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIP---NWIGTDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H+ MFE A+++   +    VIGGIISPV+D+YGK GL PS  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                       YQN+ +A K          +++L  I   +          EN +L         ++ I LLCG+DL+ESF +PGLW ++D+  I+   G+VV+ R+  + E+ +  S  L K K NI +     N   + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:    6 KTHVILLSCGSFNPITKGHIHMFEKAREYLHKTGKFIVIGGIISPVHDSYGKPGLVPSRHRLTMCQLAVQSSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVSSPSTTPVIGQPQNTNSPIYQNNNTANKPTAIKVWGKLSESLGKICCVRPHVERFTFVDENANLGTAMRYEEIELRILLLCGSDLLESFCIPGLWKESDMKVIVGDFGIVVVPRDGADTERIMNHSSVLRKHKDNIIVTKDDLNHPMSIVSSTKSRLALQHGDGHVVDYL-SQPVIDYILQSQLY 301
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:NCBI gene;Acc:103046673])

HSP 1 Score: 103.99 bits (258), Expect = 1.047e-26
Identity = 45/94 (47.87%), Postives = 60/94 (63.83%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVL 383
            R  +ILL CGSFNPIT  H+R+FELA+DH   +   +V+GGI+SPV D Y KQGL  S  R  M +LA+    ++ +D+WE  Q  W  T V +
Sbjct:    4 RIPLILLACGSFNPITYQHMRLFELARDHMHQTGLYQVVGGIVSPVGDEYAKQGLVSSQHRLAMARLALQSSDWVTVDDWESRQADWTETVVTM 97
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Match: nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:NCBI gene;Acc:103023112])

HSP 1 Score: 103.99 bits (258), Expect = 5.508e-25
Identity = 92/297 (30.98%), Postives = 135/297 (45.45%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE--------------------YQNHPSATKS---------AKTLNGISSKK--------WIENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIP---NWIGTDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H+ MF   K  F     S ++G   S      G+ GL PS  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                       YQN+ +A K          +++L  I   +          EN +L         ++ I LLCG+DL+ESF +PGLW ++D+  I+   G+VV+ R+  + E+ +  S  L K K NI +     N   + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:    6 KTHVILLSCGSFNPITKGHIHMF--GKRRF-----SFILGLRRS------GRSGLVPSRHRLTMCQLAVQSSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVSSPSTTPVIGQPQNTNSPIYQNNNTANKPTAIKVWGKLSESLGKICCVRPHVERFTFVDENANLGTAMRYEEIELRILLLCGSDLLESFCIPGLWKESDMKVIVGDFGIVVVPRDGADTERIMNHSSVLRKHKDNIIVTKDDLNHPMSIVSSTKSRLALQHGDGHVVDYL-SQPVIDYILQSQLY 288
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Sea Lamprey
Match: nmnat1 (nicotinamide nucleotide adenylyltransferase 1 [Source:ZFIN;Acc:ZDB-GENE-050417-101])

HSP 1 Score: 200.675 bits (509), Expect = 2.216e-62
Identity = 101/247 (40.89%), Postives = 143/247 (57.89%), Query Frame = 3 
Query:  111 IILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHP---SATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHD 842
            ++LL CGSFNPITNMHLRMFELA+DH + +    V+ G++SPV D YGK GL  +  R  M++ A++   +L  D WE  Q  W  T  +L     +L        +  P   S  + AK      S        +  +  + LLCGADL++SF VPGLWD  D+  I+   G+V +SR   +  K IYES+ L+K + +I L+  W+ T++SST +RR+L R  SV+YL+PD V+EYI  + LY  
Sbjct:   13 VVLLSCGSFNPITNMHLRMFELARDHLQATGQYHVVQGLLSPVGDEYGKPGLVATIHRMAMVQKAVAASGWLSADPWESEQGSWLETVKILRVHNGQLGETPVSNAEATPILGSHPRGAKRKQKWESGGVCVRSPVPGQPRVMLLCGADLLKSFQVPGLWDLADVAEIVGRFGIVCVSRCGYDCPKIIYESELLWKHRNSIHLVQEWVTTELSSTHVRRALRRGASVRYLVPDTVVEYISRHGLYQS 259
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Sea Lamprey
Match: nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:NCBI gene;Acc:336257])

HSP 1 Score: 154.836 bits (390), Expect = 1.426e-44
Identity = 102/303 (33.66%), Postives = 149/303 (49.17%), Query Frame = 3 
Query:   96 EMRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDEY---------QNHPSATKSAKTLNGISSKKWI-----------------------------ENIDLSQKI-------TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWI---GTDISSTKIRRSLSRKQS-VKYLIPDLVLEYIKENNLYHDIS 848
            + +  +ILL CGSFNP+T  HL+MFE A+D+   S    VIGGIISPV+D Y KQGL  S  R  M +LA+    ++ +D WE  Q KW  T  VLE    L KR+   +             Q H     + +  N +  +K                               EN +L   +        I LLCG+DL+ESF++PGLW+D+D+  I+   G+V + R+  + E+ I  S  L KFKKNI+++ + +      ISSTK R +L +    V   +   V++YI ++ LY + S
Sbjct:    4 QTKTHVILLACGSFNPVTKGHLQMFEDARDYLHKSGRFIVIGGIISPVHDGYRKQGLISSRHRLSMCQLAVQNSDWIRVDPWECYQEKWQTTCDVLEHHRELMKRVTGCILSNVNSPSSPVIKQPHNETRPATQDANSVPLQKSTPGKLISKFGESIGKVCCLRPKADLFPYIDENANLGNSVRYEEIELRIMLLCGSDLLESFSIPGLWNDDDLKVILAEFGVVCVPRDCADSERIIRRSRHLLKFKKNINVVNDAVDGPTAHISSTKSRLALQKGDGRVSEYLSQPVIDYILQHQLYINTS 306
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Yeast
Match: NMA1 (Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication [Source:SGD;Acc:S000004320])

HSP 1 Score: 169.088 bits (427), Expect = 3.771e-49
Identity = 92/245 (37.55%), Postives = 137/245 (55.92%), Query Frame = 3 
Query:  111 IILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAIS-GDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHD 842
            ++++ CGSF+PIT +HLRMFE+A D   + +  EVIGG  SPV+D Y KQGL PS  R +M +LA      +L++D WE  QP + RT  VL+               NH    K          K  ++         I LL G DL+ES   P +W D D+++I+ ++G +++ R   +V  F+   D +Y+ ++NI +I   I  DISSTK+R  + R  SV+YL+P+ V+ YI+E+ LY D
Sbjct:  166 LVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHF-------------NHEINIKRGGVATVTGEKIGVK---------IMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRAMSVQYLLPNSVIRYIQEHRLYVD 388
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Yeast
Match: NMA2 (Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication [Source:SGD;Acc:S000003242])

HSP 1 Score: 164.081 bits (414), Expect = 2.427e-47
Identity = 89/243 (36.63%), Postives = 137/243 (56.38%), Query Frame = 3 
Query:  111 IILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAIS-GDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +I++ CGSF+PIT +HLRMFE+A D   + +  EV+GG  SPV+D Y K+GL P+  R +M +LA      +L++D WE  Q  + RT  VL+               NH    K    +     K  ++         I LL G DL+ES   P +W D+D+++I+ ++G +++ R   +V  F+   D +Y+ ++NI +I   I  DISSTK+R  + R  SV+YL+P+ V+ YI+E NLY
Sbjct:  160 LIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHF-------------NHEINIKRGGIMTVDGEKMGVK---------IMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLY 380
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Nematostella
Match: EDO48825 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIM0])

HSP 1 Score: 205.297 bits (521), Expect = 7.715e-65
Identity = 105/243 (43.21%), Postives = 147/243 (60.49%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            K++LL CG FNP+T+MHLR+FELA+D    +    V+ GI SP +DAY K+ L  S  R  M  LA+    +L +D+WE  Q  W+ T+ VL  + ++                          ++K  +N       T+KLLCGADL+ESFAVPGLW D+DI  I++ HG+VVI+R   N E+FIY SD L K K NI ++  WI  +IS+TKIR +L R++S+KYL+PD +++YI  N LY
Sbjct:    9 KVVLLSCGCFNPVTHMHLRLFELARDTLHRTGFFTVVEGIFSPAHDAYKKKDLVASQHRLAMCNLAVKTSSWLRVDDWESKQDGWSTTKTVLNYMTEQ--------------------------ARKKHDN-----SCTVKLLCGADLLESFAVPGLWLDSDIESIVKEHGIVVITRHGSNPEEFIYNSDVLTKHKNNIHIVTEWIPNEISATKIRCALRRRESIKYLVPDSIIDYIHNNKLY 220
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:NCBI gene;Acc:101166827])

HSP 1 Score: 205.297 bits (521), Expect = 7.296e-64
Identity = 102/251 (40.64%), Postives = 151/251 (60.16%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS*R 854
            R  ++LL CGSFNPITN H+R+FELA+DH   +   +V+GGI+SPV+D YGKQGL  +  R  M KLA+    ++ +D WE  QP W  T   +ET++      +  E   H     +   L+ +S +             +KLLCGAD + SF VPGLW D  +  ++   GLV +SR +   E+ ++ESD L++ + NI L+  W+  + S+T++RR+L R  SVKYL+PD V++YI ++NLY + S R
Sbjct:    6 RVPLVLLACGSFNPITNQHMRLFELARDHLHATGQYQVMGGIVSPVSDGYGKQGLALAKHRNAMAKLALGTSSWVTVDEWESQQPDWTET---VETMRYH-SERILKELGTHRDPNGNTPPLSCVSPQ-------------LKLLCGADFLNSFKVPGLWLDKHVEELVGRFGLVCVSRGSLQSERAVHESDLLHRHRHNIFLVTEWVRNETSATEVRRALRRGLSVKYLVPDSVIDYIHQHNLYTEDSER 239
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Match: nmnat3 (nicotinamide nucleotide adenylyltransferase 3 [Source:NCBI gene;Acc:101166827])

HSP 1 Score: 205.297 bits (521), Expect = 7.296e-64
Identity = 102/251 (40.64%), Postives = 151/251 (60.16%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS*R 854
            R  ++LL CGSFNPITN H+R+FELA+DH   +   +V+GGI+SPV+D YGKQGL  +  R  M KLA+    ++ +D WE  QP W  T   +ET++      +  E   H     +   L+ +S +             +KLLCGAD + SF VPGLW D  +  ++   GLV +SR +   E+ ++ESD L++ + NI L+  W+  + S+T++RR+L R  SVKYL+PD V++YI ++NLY + S R
Sbjct:    6 RVPLVLLACGSFNPITNQHMRLFELARDHLHATGQYQVMGGIVSPVSDGYGKQGLALAKHRNAMAKLALGTSSWVTVDEWESQQPDWTET---VETMRYH-SERILKELGTHRDPNGNTPPLSCVSPQ-------------LKLLCGADFLNSFKVPGLWLDKHVEELVGRFGLVCVSRGSLQSERAVHESDLLHRHRHNIFLVTEWVRNETSATEVRRALRRGLSVKYLVPDSVIDYIHQHNLYTEDSER 239
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Match: nmnat1 (retinoid-binding protein 7 [Source:NCBI gene;Acc:101174424])

HSP 1 Score: 202.986 bits (515), Expect = 1.057e-62
Identity = 106/250 (42.40%), Postives = 154/250 (61.60%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN---IDLSQKI----TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +++LL CGSFNPITNMHLRMFELA+DH +D+    V+ GIISPV DAY K+GL  +  R +M +LA +   ++ +D+WE  Q +W      LET K  +    ++E            T++    ++  EN   I   Q+      + LLCGAD++ESFAVP LW   DI  I+  HGLV I+R   +  KFI++SD L++  +NI ++  WI  +IS+T +RR+L R  SV+YL+P+ V++YI+E  LY
Sbjct:    8 EVVLLACGSFNPITNMHLRMFELARDHLQDTGQYNVVKGIISPVGDAYRKKGLIEASHRLEMARLATANSDWIKVDDWESLQAEW------LETAK--VVRHHYEELHAEDHNKDDVDTVHHGKKRRVDENHSEISRHQERRDGPKLMLLCGADVLESFAVPNLWKQEDIAEIVGCHGLVCITRSGSDPYKFIHQSDDLWQHHRNIHVVHEWITNEISATHVRRALRRGYSVRYLLPENVIDYIQERRLY 249
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Match: nmnat1 (retinoid-binding protein 7 [Source:NCBI gene;Acc:101174424])

HSP 1 Score: 202.986 bits (515), Expect = 1.057e-62
Identity = 106/250 (42.40%), Postives = 154/250 (61.60%), Query Frame = 3 
Query:  108 KIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIEN---IDLSQKI----TIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLY 836
            +++LL CGSFNPITNMHLRMFELA+DH +D+    V+ GIISPV DAY K+GL  +  R +M +LA +   ++ +D+WE  Q +W      LET K  +    ++E            T++    ++  EN   I   Q+      + LLCGAD++ESFAVP LW   DI  I+  HGLV I+R   +  KFI++SD L++  +NI ++  WI  +IS+T +RR+L R  SV+YL+P+ V++YI+E  LY
Sbjct:    8 EVVLLACGSFNPITNMHLRMFELARDHLQDTGQYNVVKGIISPVGDAYRKKGLIEASHRLEMARLATANSDWIKVDDWESLQAEW------LETAK--VVRHHYEELHAEDHNKDDVDTVHHGKKRRVDENHSEISRHQERRDGPKLMLLCGADVLESFAVPNLWKQEDIAEIVGCHGLVCITRSGSDPYKFIHQSDDLWQHHRNIHVVHEWITNEISATHVRRALRRGYSVRYLLPENVIDYIQERRLY 249
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Match: nmnat2 (nicotinamide nucleotide adenylyltransferase 2 [Source:NCBI gene;Acc:101156529])

HSP 1 Score: 145.591 bits (366), Expect = 1.111e-39
Identity = 103/298 (34.56%), Postives = 147/298 (49.33%), Query Frame = 3 
Query:  102 RNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLE---TLKKRLPNDLFDE--------------------YQNH------PSATKSAKTLNGISSKKWI------------ENIDLSQ-------KITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLI---PNWIGTDISSTKIRRSLSRKQS--VKYLIPDLVLEYIKENNLY 836
            +  +ILL CGSFNPIT  H+ MFE A+++   +    VIGGI+SPV+D+YGK GL  S  R  M +LA+    ++ +D WE  Q  W  T  VLE    L KR+   +                       YQNH      P+A K    L+   S+               EN +L         ++ I LLCG+DL+ESF +PGLW D+D+  I+   G+VV+ R+  + EK +  S  L  FK+NI ++    N   + +SSTK R +L       V YL    V++YI ++ LY
Sbjct:   70 KTHVILLSCGSFNPITKGHIHMFEKAREYLHKTGRFIVIGGIVSPVHDSYGKPGLVSSRHRLTMCQLAVQSSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSSTPVIGQPQNQTQSLYQNHSNMKHKPTAVKVWGKLSENLSRMCCVRPQMDRFPFVDENANLGTTMRYEEIELRILLLCGSDLLESFCIPGLWKDSDMEVIVGDFGIVVVPRDGVDTEKIMNHSSILRNFKENIIVVKDDTNHPMSIVSSTKSRLALQHGDGHVVDYL-SQPVIDYILQSQLY 366
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Planmine SMEST
Match: SMESG000055048.1 (SMESG000055048.1)

HSP 1 Score: 513.457 bits (1321), Expect = 0.000e+0
Identity = 250/250 (100.00%), Postives = 250/250 (100.00%), Query Frame = 3 
Query:   99 MRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 848
            MRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS
Sbjct:    1 MRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 250
[Close]
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Planmine SMEST
Match: SMESG000055048.1 (SMESG000055048.1)

HSP 1 Score: 476.863 bits (1226), Expect = 3.976e-171
Identity = 232/232 (100.00%), Postives = 232/232 (100.00%), Query Frame = 3 
Query:  153 MHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 848
            MHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS
Sbjct:    1 MHLRMFELAKDHFRDSSTSEVIGGIISPVNDAYGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKKRLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGADLVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKKNIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS 232
The following BLAST results are available for this feature:
BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NMNAT12.689e-7646.67nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
NMNAT12.689e-7646.67nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
NMNAT37.675e-5741.22nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
NMNAT24.025e-4034.23nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
NMNAT32.076e-3737.80nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
nmat-24.931e-3131.62Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
nmat-12.250e-2130.59Nicotinamide-nucleotide adenylyltransferase [Sour... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Nmnat3.829e-7146.15gene:FBgn0039254 transcript:FBtr0473366[more]
Nmnat1.583e-7046.15gene:FBgn0039254 transcript:FBtr0084750[more]
Nmnat6.603e-7046.94gene:FBgn0039254 transcript:FBtr0337012[more]
Nmnat1.986e-6946.94gene:FBgn0039254 transcript:FBtr0084749[more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nmnat14.322e-6541.41nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
nmnat14.322e-6541.41nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
nmnat31.185e-6242.45nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
nmnat21.759e-4033.56nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
nmnat34.757e-3336.26nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
nmnat11.173e-6142.23nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
nmnat12.824e-6142.23nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
hmgxb32.928e-4034.54HMG-box containing 3 [Source:Xenbase;Acc:XB-GENE-9... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nmnat11.806e-6845.31nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
Nmnat11.806e-6845.31nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
Nmnat32.873e-5740.73nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
Nmnat27.955e-4033.56nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
Nmnat21.069e-3733.33nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9HAN9|NMNA1_HUMAN1.291e-7546.67Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
sp|Q0VD50|NMNA1_BOVIN6.445e-7347.41Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
sp|Q9EPA7|NMNA1_MOUSE1.263e-6745.31Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
sp|Q99JR6|NMNA3_MOUSE2.009e-5640.73Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
sp|Q96T66|NMNA3_HUMAN3.686e-5641.22Nicotinamide/nicotinic acid mononucleotide adenyly... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
D3TNV99.205e-7648.37Nicotinamide-nucleotide adenylyltransferase (Fragm... [more]
A0A1A9X1T83.533e-7548.77Nicotinamide-nucleotide adenylyltransferase OS=Glo... [more]
A0A4D5RX401.637e-7446.22Nicotinamide-nucleotide adenylyltransferase (Fragm... [more]
A0A1A9Y7D22.247e-7447.56Nicotinamide-nucleotide adenylyltransferase OS=Glo... [more]
A0A1B0BDE52.503e-7447.56Nicotinamide-nucleotide adenylyltransferase OS=Glo... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nmnat12.098e-6942.35nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
nmnat33.500e-6342.17nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
nmnat26.615e-3934.01nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
nmnat31.047e-2647.87nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
nmnat25.508e-2530.98nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
nmnat12.216e-6240.89nicotinamide nucleotide adenylyltransferase 1 [Sou... [more]
nmnat21.426e-4433.66nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
NMA13.771e-4937.55Nicotinic acid mononucleotide adenylyltransferase;... [more]
NMA22.427e-4736.63Nicotinic acid mononucleotide adenylyltransferase;... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO488257.715e-6543.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nmnat37.296e-6440.64nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
nmnat37.296e-6440.64nicotinamide nucleotide adenylyltransferase 3 [Sou... [more]
nmnat11.057e-6242.40retinoid-binding protein 7 [Source:NCBI gene;Acc:1... [more]
nmnat11.057e-6242.40retinoid-binding protein 7 [Source:NCBI gene;Acc:1... [more]
nmnat21.111e-3934.56nicotinamide nucleotide adenylyltransferase 2 [Sou... [more]
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BLAST of Nicotinamide-nucleotide adenylyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000055048.10.000e+0100.00SMESG000055048.1[more]
SMESG000055048.13.976e-171100.00SMESG000055048.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000801 ID=SMED30000801|Name=Nicotinamide-nucleotide adenylyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=1134bp
AGAATTCGAAGATTTAGATTTTTCACAAAATTAATACAAAATGTATTAAT
GCGGTATTATAAATTTTATTAATTTTGTTATTATATTTTTTTGGAGAAAT
GCGTAACAAAATCATACTTTTATTATGTGGATCATTCAATCCAATTACGA
ATATGCATCTTAGAATGTTTGAACTTGCAAAAGATCATTTTCGAGATAGC
AGTACTTCAGAAGTAATAGGTGGTATTATATCTCCTGTCAATGATGCGTA
TGGGAAACAAGGCCTTCAACCCTCACCTCAGCGCTGCAAAATGATAAAAC
TAGCAATATCAGGGGACCCATTTCTGTTAATAGATAATTGGGAGGTTAGC
CAACCTAAATGGAACAGAACTAGAGTTGTTCTGGAAACCTTAAAGAAACG
ACTTCCCAATGATTTGTTTGATGAATATCAAAATCATCCTTCTGCAACAA
AATCTGCAAAAACTCTAAATGGGATTTCATCAAAAAAGTGGATTGAAAAT
ATCGATTTATCTCAAAAAATAACAATCAAATTACTCTGTGGGGCTGATCT
GGTTGAAAGCTTTGCAGTGCCGGGTTTATGGGATGACAATGACATCAATT
ATATAATGGAGCATCATGGACTTGTCGTAATCAGCAGAGAGAATTGCAAT
GTGGAAAAGTTCATTTACGAATCTGACAAATTGTACAAGTTTAAGAAAAA
TATCGATCTAATTCCAAATTGGATTGGAACAGATATTAGTTCTACAAAAA
TTCGTCGATCTCTAAGTAGGAAACAAAGTGTAAAGTATCTCATTCCAGAC
CTGGTTCTGGAATACATAAAGGAGAACAATCTCTATCATGACATCTCTTA
AAGAGTCTTTATATTTAAATCCATTGAAGCTTTGTGTATTTTTGTGTTAT
TTATATTACCTACAATAGAGAAAGATGAAGCTCCGATTTATTGGGATTTG
TGATTGTATTTTGTTATTTAATATTTATATAAATATTTATGTCAACTTTT
GTTTCCGTGTGTGAATTAGAAATGCTTCGTAAATTGCTTAAGATTTTTTT
TTCCATTTTCAAAATATCTTAACTAAGTTTTACATATTTATATTCATTTT
GATGCTTGTAGATGTTCGTATTTTTTAATTACCT
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protein sequence of SMED30000801-orf-1

>SMED30000801-orf-1 ID=SMED30000801-orf-1|Name=SMED30000801-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=251bp
MRNKIILLLCGSFNPITNMHLRMFELAKDHFRDSSTSEVIGGIISPVNDA
YGKQGLQPSPQRCKMIKLAISGDPFLLIDNWEVSQPKWNRTRVVLETLKK
RLPNDLFDEYQNHPSATKSAKTLNGISSKKWIENIDLSQKITIKLLCGAD
LVESFAVPGLWDDNDINYIMEHHGLVVISRENCNVEKFIYESDKLYKFKK
NIDLIPNWIGTDISSTKIRRSLSRKQSVKYLIPDLVLEYIKENNLYHDIS
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR005248NadD/NMNAT
IPR014729Rossmann-like_a/b/a_fold
IPR004821Cyt_trans-like
Vocabulary: biological process
TermDefinition
GO:0009058biosynthetic process
GO:0009435NAD biosynthetic process
GO:0019363pyridine nucleotide biosynthetic process
Vocabulary: molecular function
TermDefinition
GO:0003824catalytic activity
GO:0000166nucleotide binding
GO:0000309nicotinamide-nucleotide adenylyltransferase activity
GO:0004515nicotinate-nucleotide adenylyltransferase activity
GO:0005524ATP binding
GO:0016740transferase activity
GO:0016779nucleotidyltransferase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR004821Cytidyltransferase-like domainPFAMPF01467CTP_transf_likecoord: 8..220
e-value: 4.5E-27
score: 95.0
IPR014729Rossmann-like alpha/beta/alpha sandwich foldGENE3DG3DSA:3.40.50.620coord: 1..246
e-value: 8.6E-78
score: 263.1
IPR005248Nicotinate/nicotinamide nucleotide adenylyltransferaseTIGRFAMTIGR00482TIGR00482coord: 8..246
e-value: 4.6E-44
score: 148.7
NoneNo IPR availablePANTHERPTHR12039NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASEcoord: 3..248
NoneNo IPR availableSUPERFAMILYSSF52374Nucleotidylyl transferasecoord: 4..248