Serine/threonine-protein kinase OSR1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30000705 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Match: STK39 (serine/threonine kinase 39 [Source:HGNC Symbol;Acc:HGNC:17717]) HSP 1 Score: 345.125 bits (884), Expect = 6.282e-112 Identity = 210/498 (42.17%), Postives = 290/498 (58.23%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQ-PVQKSKISVTE-------NVFYR--------ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK N+ + +GVL+E IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + K+++RE L + LL P +R KVR DEK E+ FS E + +K ++ + + P Q +SV + N YR + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V +P ++ F L S S + E L G+A++
Sbjct: 56 WPICRDAYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ-KAKNREYLIEKLLT-RTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 542
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Match: OXSR1 (oxidative stress responsive kinase 1 [Source:HGNC Symbol;Acc:HGNC:8508]) HSP 1 Score: 316.62 bits (810), Expect = 7.203e-102 Identity = 163/319 (51.10%), Postives = 212/319 (66.46%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR 1016
W N+ DY ++ IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK K + SGVLDE+TIATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F + K++++E L + L P ER KVR
Sbjct: 10 WSINRDDYELQEVIGSGATAVVQAAYC-APKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ-KAKNKEFLQEKTLQ-RAPTISERAKKVR 319
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Match: OXSR1 (oxidative stress responsive kinase 1 [Source:HGNC Symbol;Acc:HGNC:8508]) HSP 1 Score: 317.005 bits (811), Expect = 3.461e-101 Identity = 163/319 (51.10%), Postives = 212/319 (66.46%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR 1016
W N+ DY ++ IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK K + SGVLDE+TIATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F + K++++E L + L P ER KVR
Sbjct: 10 WSINRDDYELQEVIGSGATAVVQAAYC-APKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ-KAKNKEFLQEKTLQ-RAPTISERAKKVR 319 HSP 2 Score: 58.9214 bits (141), Expect = 1.342e-8 Identity = 38/105 (36.19%), Postives = 63/105 (60.00%), Query Frame = 3
Query: 1119 QKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
Q++KI ++ + LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP + R F L S S + + L G+A++
Sbjct: 428 QETKIPIS------LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 196.823 bits (499), Expect = 5.977e-56 Identity = 110/278 (39.57%), Postives = 160/278 (57.55%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKS 938
+G+G+ +VY+A K +I+ +++ + L EI KEI M+ + ++V YY S T+L I+M+ C GS+ DII+ + + L E+ IATI++ LKGL Y+H +HRD+K GN+L+ + ++ADFGVAG L M+ KR T +GTP WMAPEV+Q++ GYN ADIWS+GIT IEMA G+ PYA PM+ + + N PP S+ +T+ F K CL K P QR +A +LLQ PF++S
Sbjct: 36 LGEGSYGSVYKAI------HKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-------LRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL------TDTMA---KRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTD-------FVKQCLVKSPEQRATATQLLQHPFVRS 283
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Match: STK4 (serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408]) HSP 1 Score: 195.667 bits (496), Expect = 1.067e-55 Identity = 109/278 (39.21%), Postives = 158/278 (56.83%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKS 938
+G+G+ +VY+A K +I+ +++ + L EI KEI M+ + ++V YY S T+L I+M+ C GS+ DII+ + + L E+ IATI++ LKGL Y+H +HRD+K GN+L+ + ++ADFGVAG L KR T +GTP WMAPEV+Q++ GYN ADIWS+GIT IEMA G+ PYA PM+ + + N PP S+ +T+ F K CL K P QR +A +LLQ PF++S
Sbjct: 36 LGEGSYGSVYKAI------HKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-------LRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT---------DTMAKRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTD-------FVKQCLVKSPEQRATATQLLQHPFVRS 283
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4]) HSP 1 Score: 325.865 bits (834), Expect = 6.516e-105 Identity = 167/344 (48.55%), Postives = 220/344 (63.95%), Query Frame = 3
Query: 54 PIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIK---ATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN--CDIPPAPERKVRDEKQEKNPKDFSGEWNFD 1070
P +WP S Y + SIG GAT+TV+ A C + N K A+K INLEKC +S +DE+ EI+ M + N+V+YY S +A EL ++M L GS+LDI+K K GVLDE +IAT++++VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+G+LA+ +S R TFVGTPCWMAPEVM+QV+GY+ KADIWS+GI IE+ATG APY KY PMKVLMLTLQNDPP ++T A +QY YG ++ + CL KDP++RP+A ELL+ F K K +D++ L L+ +P + K KD G W F+
Sbjct: 97 PADRWPTEPSAYKLDESIGVGATATVFTAYC-LPRNEKVAIKCINLEKCQTS--VDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLAS---SGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFK-KGKDKKYLVHTLIENLASVPVVAHHSSKKVASGKLRKDAHGNWEFE 433
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4]) HSP 1 Score: 326.635 bits (836), Expect = 1.320e-104 Identity = 167/344 (48.55%), Postives = 220/344 (63.95%), Query Frame = 3
Query: 54 PIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIK---ATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN--CDIPPAPERKVRDEKQEKNPKDFSGEWNFD 1070
P +WP S Y + SIG GAT+TV+ A C + N K A+K INLEKC +S +DE+ EI+ M + N+V+YY S +A EL ++M L GS+LDI+K K GVLDE +IAT++++VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+G+LA+ +S R TFVGTPCWMAPEVM+QV+GY+ KADIWS+GI IE+ATG APY KY PMKVLMLTLQNDPP ++T A +QY YG ++ + CL KDP++RP+A ELL+ F K K +D++ L L+ +P + K KD G W F+
Sbjct: 97 PADRWPTEPSAYKLDESIGVGATATVFTAYC-LPRNEKVAIKCINLEKCQTS--VDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLAS---SGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFK-KGKDKKYLVHTLIENLASVPVVAHHSSKKVASGKLRKDAHGNWEFE 433 HSP 2 Score: 60.077 bits (144), Expect = 2.796e-9 Identity = 39/96 (40.62%), Postives = 57/96 (59.38%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV----AEPTMRERVFALNSP-PASGVISEADLNGYAKVLL 1433
+ LR RN Q EL DI F+Y D+V+ +A ELV A+L+D DL++VA NL +L+ ++ R FALNS A+ + E L G+A++ L
Sbjct: 501 MVLRVRN--QQRELNDIKFDYTKSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERTLTGFAQISL 594
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4]) HSP 1 Score: 276.174 bits (705), Expect = 5.176e-87 Identity = 137/280 (48.93%), Postives = 180/280 (64.29%), Query Frame = 3
Query: 246 MRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIK---ATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN--CDIPPAPERKVRDEKQEKNPKDFSGEWNFD 1070
M + N+V+YY S +A EL ++M L GS+LDI+K K GVLDE +IAT++++VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+G+LA+ +S R TFVGTPCWMAPEVM+QV+GY+ KADIWS+GI IE+ATG APY KY PMKVLMLTLQNDPP ++T A +QY YG ++ + CL KDP++RP+A ELL+ F K K +D++ L L+ +P + K KD G W F+
Sbjct: 1 MSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLAS---SGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFK-KGKDKKYLVHTLIENLASVPVVAHHSSKKVASGKLRKDAHGNWEFE 276 HSP 2 Score: 59.6918 bits (143), Expect = 2.729e-9 Identity = 39/96 (40.62%), Postives = 57/96 (59.38%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV----AEPTMRERVFALNSP-PASGVISEADLNGYAKVLL 1433
+ LR RN Q EL DI F+Y D+V+ +A ELV A+L+D DL++VA NL +L+ ++ R FALNS A+ + E L G+A++ L
Sbjct: 344 MVLRVRN--QQRELNDIKFDYTKSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERTLTGFAQISL 437
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 201.06 bits (510), Expect = 9.021e-57 Identity = 108/280 (38.57%), Postives = 167/280 (59.64%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIK 935
IG+G+ VY+ ++NR A+KII+LE+ +++I++EI+ + ++ + Y+ S + G++L I+M+ GS LD+ K SG LDE+ IA I++++LKGL Y+H +HRD+K N+LV + +++ADFGVAG L KR TFVG+P WMAPE+++Q Y+ KADIWS+GIT IE+A G+ P++ PM+VL L +N PP + Q + + +++F ++CL KDP RPSA LL+ FIK
Sbjct: 20 IGRGSFGEVYKG----IDNRTGRVVAIKIIDLEQAEDE--IEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTK---------SGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLT---------ETVKKRITFVGSPFWMAPELIKQ-SSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVL--------QGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIK 266
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099]) HSP 1 Score: 201.06 bits (510), Expect = 9.966e-57 Identity = 108/280 (38.57%), Postives = 167/280 (59.64%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIK 935
IG+G+ VY+ ++NR A+KII+LE+ +++I++EI+ + ++ + Y+ S + G++L I+M+ GS LD+ K SG LDE+ IA I++++LKGL Y+H +HRD+K N+LV + +++ADFGVAG L KR TFVG+P WMAPE+++Q Y+ KADIWS+GIT IE+A G+ P++ PM+VL L +N PP + Q + + +++F ++CL KDP RPSA LL+ FIK
Sbjct: 25 IGRGSFGEVYKG----IDNRTGRVVAIKIIDLEQAEDE--IEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTK---------SGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLT---------ETVKKRITFVGSPFWMAPELIKQ-SSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVL--------QGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIK 271
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Match: fray (gene:FBgn0023083 transcript:FBtr0083638) HSP 1 Score: 341.273 bits (874), Expect = 1.184e-110 Identity = 181/355 (50.99%), Postives = 234/355 (65.92%), Query Frame = 3
Query: 30 GTAPDASHPIVQ--WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDK--RFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEW 1061
T P A+ P + WPN+K DY ++ IG GAT+ V+ A C I N KCA+K INLEK ++S +DE+ KEI+ M + +EN+VTY+ S V EL +++ L + GSLLDIIK + GV DE TIAT++K+VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+ +LA TG L + R TFVGTPCWMAPEVM+Q GY+ KADIWS GIT IEMATG APY KY PMKVLMLTLQNDPP +DT A +QY YG +RK CL K+PS+RP+A ELL+ F K K++DR+ L++ LL P+ E +V + ++ P + +GEW
Sbjct: 17 ATLPGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVHGAYC-IPRNEKCAIKRINLEKWNTS--MDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA------TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK-KAKDRKYLTQTLLQSG--PSMETRVH-KAAKRQPGASGRLHRTVTGEW 358 HSP 2 Score: 58.151 bits (139), Expect = 1.275e-8 Identity = 37/91 (40.66%), Postives = 55/91 (60.44%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV-AEPTMRERVFALNSPPASG-VISEADLNGYAKV 1427
+ LR RN ++ EL DI F +V+GKD+ + +A ELV+A L+D D +A +L +L+ A TM+ F L+S G V E L GYA++
Sbjct: 460 LVLRMRNLRR--ELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQI 548
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Match: fray (gene:FBgn0023083 transcript:FBtr0347418) HSP 1 Score: 341.273 bits (874), Expect = 1.184e-110 Identity = 181/355 (50.99%), Postives = 234/355 (65.92%), Query Frame = 3
Query: 30 GTAPDASHPIVQ--WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDK--RFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEW 1061
T P A+ P + WPN+K DY ++ IG GAT+ V+ A C I N KCA+K INLEK ++S +DE+ KEI+ M + +EN+VTY+ S V EL +++ L + GSLLDIIK + GV DE TIAT++K+VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+ +LA TG L + R TFVGTPCWMAPEVM+Q GY+ KADIWS GIT IEMATG APY KY PMKVLMLTLQNDPP +DT A +QY YG +RK CL K+PS+RP+A ELL+ F K K++DR+ L++ LL P+ E +V + ++ P + +GEW
Sbjct: 17 ATLPGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVHGAYC-IPRNEKCAIKRINLEKWNTS--MDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA------TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK-KAKDRKYLTQTLLQSG--PSMETRVH-KAAKRQPGASGRLHRTVTGEW 358 HSP 2 Score: 58.151 bits (139), Expect = 1.275e-8 Identity = 37/91 (40.66%), Postives = 55/91 (60.44%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV-AEPTMRERVFALNSPPASG-VISEADLNGYAKV 1427
+ LR RN ++ EL DI F +V+GKD+ + +A ELV+A L+D D +A +L +L+ A TM+ F L+S G V E L GYA++
Sbjct: 460 LVLRMRNLRR--ELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQI 548
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Match: fray (gene:FBgn0023083 transcript:FBtr0290210) HSP 1 Score: 341.273 bits (874), Expect = 1.184e-110 Identity = 181/355 (50.99%), Postives = 234/355 (65.92%), Query Frame = 3
Query: 30 GTAPDASHPIVQ--WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDK--RFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEW 1061
T P A+ P + WPN+K DY ++ IG GAT+ V+ A C I N KCA+K INLEK ++S +DE+ KEI+ M + +EN+VTY+ S V EL +++ L + GSLLDIIK + GV DE TIAT++K+VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+ +LA TG L + R TFVGTPCWMAPEVM+Q GY+ KADIWS GIT IEMATG APY KY PMKVLMLTLQNDPP +DT A +QY YG +RK CL K+PS+RP+A ELL+ F K K++DR+ L++ LL P+ E +V + ++ P + +GEW
Sbjct: 17 ATLPGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVHGAYC-IPRNEKCAIKRINLEKWNTS--MDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA------TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK-KAKDRKYLTQTLLQSG--PSMETRVH-KAAKRQPGASGRLHRTVTGEW 358 HSP 2 Score: 58.151 bits (139), Expect = 1.275e-8 Identity = 37/91 (40.66%), Postives = 55/91 (60.44%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV-AEPTMRERVFALNSPPASG-VISEADLNGYAKV 1427
+ LR RN ++ EL DI F +V+GKD+ + +A ELV+A L+D D +A +L +L+ A TM+ F L+S G V E L GYA++
Sbjct: 460 LVLRMRNLRR--ELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQI 548
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Match: fray (gene:FBgn0023083 transcript:FBtr0290107) HSP 1 Score: 341.273 bits (874), Expect = 1.184e-110 Identity = 181/355 (50.99%), Postives = 234/355 (65.92%), Query Frame = 3
Query: 30 GTAPDASHPIVQ--WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDK--RFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEW 1061
T P A+ P + WPN+K DY ++ IG GAT+ V+ A C I N KCA+K INLEK ++S +DE+ KEI+ M + +EN+VTY+ S V EL +++ L + GSLLDIIK + GV DE TIAT++K+VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+ +LA TG L + R TFVGTPCWMAPEVM+Q GY+ KADIWS GIT IEMATG APY KY PMKVLMLTLQNDPP +DT A +QY YG +RK CL K+PS+RP+A ELL+ F K K++DR+ L++ LL P+ E +V + ++ P + +GEW
Sbjct: 17 ATLPGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVHGAYC-IPRNEKCAIKRINLEKWNTS--MDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA------TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK-KAKDRKYLTQTLLQSG--PSMETRVH-KAAKRQPGASGRLHRTVTGEW 358 HSP 2 Score: 58.151 bits (139), Expect = 1.275e-8 Identity = 37/91 (40.66%), Postives = 55/91 (60.44%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV-AEPTMRERVFALNSPPASG-VISEADLNGYAKV 1427
+ LR RN ++ EL DI F +V+GKD+ + +A ELV+A L+D D +A +L +L+ A TM+ F L+S G V E L GYA++
Sbjct: 460 LVLRMRNLRR--ELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQI 548
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Match: fray (gene:FBgn0023083 transcript:FBtr0347417) HSP 1 Score: 341.273 bits (874), Expect = 1.184e-110 Identity = 181/355 (50.99%), Postives = 234/355 (65.92%), Query Frame = 3
Query: 30 GTAPDASHPIVQ--WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDK--RFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEW 1061
T P A+ P + WPN+K DY ++ IG GAT+ V+ A C I N KCA+K INLEK ++S +DE+ KEI+ M + +EN+VTY+ S V EL +++ L + GSLLDIIK + GV DE TIAT++K+VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+ +LA TG L + R TFVGTPCWMAPEVM+Q GY+ KADIWS GIT IEMATG APY KY PMKVLMLTLQNDPP +DT A +QY YG +RK CL K+PS+RP+A ELL+ F K K++DR+ L++ LL P+ E +V + ++ P + +GEW
Sbjct: 17 ATLPGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVHGAYC-IPRNEKCAIKRINLEKWNTS--MDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLA------TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK-KAKDRKYLTQTLLQSG--PSMETRVH-KAAKRQPGASGRLHRTVTGEW 358 HSP 2 Score: 58.151 bits (139), Expect = 1.275e-8 Identity = 37/91 (40.66%), Postives = 55/91 (60.44%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV-AEPTMRERVFALNSPPASG-VISEADLNGYAKV 1427
+ LR RN ++ EL DI F +V+GKD+ + +A ELV+A L+D D +A +L +L+ A TM+ F L+S G V E L GYA++
Sbjct: 460 LVLRMRNLRR--ELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQI 548
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Match: stk39 (serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GENE-140106-194]) HSP 1 Score: 342.813 bits (878), Expect = 2.215e-111 Identity = 198/482 (41.08%), Postives = 274/482 (56.85%), Query Frame = 3
Query: 54 PIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP---------KDFSGEWNFDIXXXXXXXXXXXXQPVQKSKISVTENVFYRI--------------------------------TLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS 1373
P WP K Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK T NK + +GVLDE+TIA+I+K+VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FL+ ++ R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL KDP++RP+A ELL+ F + K+++RE L + LL P R +K + P +D EW+ D + + + ++ EN + LR RN K+ EL DI F + G+D+ D +++EL A L++G D+++VA NL ++V +P T + F L S
Sbjct: 58 PTTGWPIVKEAYELQEVIGSGATAVVQAALCSPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSVLDIIKHTFNKGEHRNGVLDESTIASILKEVLEGLDYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLST----GGDVTRHKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPSLETGVEDKEMLKKYGKSFRKLISLCLQKDPAKRPTAAELLKCKFFQ-KAKNREYLMEKLLT----KGPNISQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDERSEEGKAAVNHERSRRVKENENQHGEVNANSLPLEDLSIQHPQVQPLEKPSSAHGAVNMVLRLRNSKK--ELNDIRFEFTPGQDTADGVSQELFSAGLVNGHDVVVVAANLQKIVEDPVTYKVLTFKLVS 525
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Match: oxsr1b (oxidative stress responsive kinase 1b [Source:ZFIN;Acc:ZDB-GENE-040426-723]) HSP 1 Score: 314.694 bits (805), Expect = 1.114e-100 Identity = 166/341 (48.68%), Postives = 217/341 (63.64%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
W NK DY ++ IG GAT+ V A C + K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LD+IK +K + +GVLDE +IAT++K+VL+GL Y+H+NG +HRDLK GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QVKGY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG RK CL K+P +RP++ ELL+ F + K+++ E L + LL+ AP R K + P K GEW +
Sbjct: 10 WSINKDDYELQEVIGSGATAVVQAAYC-VPRKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDVIKHIISKGEHKTGVLDEPSIATVLKEVLQGLEYLHKNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVKGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPCLETGITDKEMVKKYGKSLRKMISQCLQKEPEKRPTSSELLKHKFFQ-KAKNNEFLQEKLLHR----APTITERARKVRRVPGSSGRLHKTEDGEWEW 338 HSP 2 Score: 58.5362 bits (140), Expect = 1.218e-8 Identity = 36/78 (46.15%), Postives = 51/78 (65.38%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSPPASGV 1391
+ LR RN K+ EL DI F ++ G+D+ D +++ELV A L+DG DL++VA NL ++V EP + V F L ASGV
Sbjct: 429 LVLRLRNLKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGKDLVIVAANLQKIVEEPHSNKNVTFKL----ASGV 500
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Match: oxsr1a (oxidative stress responsive kinase 1a [Source:ZFIN;Acc:ZDB-GENE-070620-25]) HSP 1 Score: 310.457 bits (794), Expect = 4.808e-99 Identity = 163/341 (47.80%), Postives = 216/341 (63.34%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
W +K DY ++ IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LD IK +K + SGV+DE +IATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F +K+++ + L + LL AP R K + P K GEW +
Sbjct: 10 WSIDKDDYELQEVIGSGATAVVQAAYCKP-RKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDFIKYIISKGEHKSGVMDEPSIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADLWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPCLETGVTDKEMVKKYGKSFRKMISLCLQKDPEKRPTAAELLKHKFF-TKAKNTDYLKEKLLER----APTIGERSRKVRRVPGSSGRLHKTEDGEWEW 338 HSP 2 Score: 58.9214 bits (141), Expect = 9.393e-9 Identity = 39/95 (41.05%), Postives = 59/95 (62.11%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSPPASGVIS-----EADLNGYAKV 1427
+ LR RN K+ EL DI F ++ G+D+ D +++ELV A L+DG DL++VA NL ++V +P + V F L ASGV S + L G+A++
Sbjct: 424 LVLRLRNTKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDLVIVAANLQKIVDDPQTHKNVTFKL----ASGVDSSEIPDDVKLMGFAQL 512
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Match: oxsr1a (oxidative stress responsive kinase 1a [Source:ZFIN;Acc:ZDB-GENE-070620-25]) HSP 1 Score: 240.736 bits (613), Expect = 2.850e-76 Identity = 114/212 (53.77%), Postives = 149/212 (70.28%), Query Frame = 3
Query: 216 LDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKY 851
+DE+ KEI+ M + NIV+YY S V EL ++M L GS+LD IK +K + SGV+DE +IATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +
Sbjct: 1 MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDFIKYIISKGEHKSGVMDEPSIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADLWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPCLETGVTDKEMVKKYGKSF 208
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 194.126 bits (492), Expect = 8.404e-56 Identity = 113/304 (37.17%), Postives = 173/304 (56.91%), Query Frame = 3
Query: 75 NKSDYIIK-GSIGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
N +Y K IG+G+ VY+ +NNR A+KII+LE+ + +EI + + + YY S + G++L I+M+ GS LD+++ G L+E IATI++++LKGL Y+H +HRD+K N+L+ + +++ADFGVAG L + KR TFVGTP WMAPEV++Q Y+ KADIWS+GIT IE+A G+ P A+ PM+VL L +N+PP ++ + Y ++ F + CL K+P RP+AKELL+ FI ++ LS+++
Sbjct: 15 NPEEYFTKLERIGKGSFGEVYKG----INNRTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYVTKYYGSYLTGSKLWIIMEYLGGGSALDLLRP---------GTLEEVYIATILREILKGLDYLHSERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQI---------KRNTFVGTPFWMAPEVIKQ-SAYDFKADIWSLGITAIELAKGEPPNAELHPMRVLFLIPKNNPPTLEGS---------YSKAFKDFVEACLNKEPRFRPTAKELLKHKFITRYTKKTSYLSELI 284
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Match: hipk3 (homeodomain interacting protein kinase 3 [Source:Xenbase;Acc:XB-GENE-1010053]) HSP 1 Score: 350.903 bits (899), Expect = 9.599e-114 Identity = 202/461 (43.82%), Postives = 281/461 (60.95%), Query Frame = 3
Query: 39 PDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRE-LLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNFDIXXXXXXXXXXXXQPVQKSKI-------SVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS 1373
P A+ PI WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDIIK + + +GVL+E+ IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + KS++RE L+ K+L+ P +R +K + P K+ G+W + + ++ SS K K+ SV N +T +N ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL +++ +P T + F L S
Sbjct: 120 PPAAQPI-GWPICRDSYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNIVTYYTSFVVKEELWLVMKLLSGGSMLDIIKHVVGRGEHKNGVLEESIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSSFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKCKFFQ-KSKNREYLIEKLLIK-----TPNIALRGKKVRRVPGSSGHLHKNEDGDWEWS-DDELEEKSSEFKDSYSKEKVIFNPTPKSVDNNELKSLTFFIKNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKMIDDPLTYKSLTFKLVS 563
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Match: sap130 (Sin3A associated protein 130kDa [Source:Xenbase;Acc:XB-GENE-6083596]) HSP 1 Score: 342.813 bits (878), Expect = 2.945e-112 Identity = 196/462 (42.42%), Postives = 268/462 (58.01%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFI-KSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNPKDFSGEWNFDIXXXXXXXXXXX-----XQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
W N+ DY ++ IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK K + +GVLDE +IAT++K+VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK CL KDP +RP+A ELL+ F K+K E + + + P R + +D EW+ D ++ + +P K + + N EL DI F + G+D+ D +++ELV A L+DG DL++VA NL ++V EP T R F L S S + + L G+A++
Sbjct: 11 WSINRDDYELQEVIGSGATAVVQAAFCAP-KKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIIAKGEHKNGVLDEASIATMLKEVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVQDKEMLKKYGKSFRKMISSCLQKDPEKRPTAAELLKHKFFQKAKELGAEWVPSLFIFTSAPIQVRRVPGSSGRLHKTEDGGWEWSDDELDEESEEGKAAILQLRVRPPAKFPLYINRNT-------------KKELNDIRFEFTPGRDTADGVSQELVSAGLVDGRDLVIVAANLQKIVDEPQTHRSVTFKLASGVDPSDIPDDGKLVGFAQL 452
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Match: hipk3 (homeodomain interacting protein kinase 3 [Source:Xenbase;Acc:XB-GENE-1010053]) HSP 1 Score: 345.125 bits (884), Expect = 4.130e-111 Identity = 210/510 (41.18%), Postives = 295/510 (57.84%), Query Frame = 3
Query: 39 PDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRE-LLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF-DIXXXXXXXXXXXXQPVQKSK---------ISVTENVFYRI---------------------------TLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
P A+ PI WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDIIK + + +GVL+E+ IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + KS++RE L+ K+L+ P +R +K + P K+ G+W + D + ++ S D +KS+ I+ N+ RI LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL +++ +P T + F L S + + E L G+A++
Sbjct: 120 PPAAQPI-GWPICRDSYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNIVTYYTSFVVKEELWLVMKLLSGGSMLDIIKHVVGRGEHKNGVLEESIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSSFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKCKFFQ-KSKNREYLIEKLLIK-----TPNIALRGKKVRRVPGSSGHLHKNEDGDWEWSDDELEEKSSEFKDSYSKEKSRRDNESNNAEITTDSNMQTRIQNLSLQDTQAQSNESHVESGLPSAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKMIDDPLTYKSLTFKLVSGCDGTEIPDEVKLIGFAQL 613
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Match: hipk3 (homeodomain interacting protein kinase 3 [Source:Xenbase;Acc:XB-GENE-1010053]) HSP 1 Score: 337.421 bits (864), Expect = 1.898e-109 Identity = 204/491 (41.55%), Postives = 284/491 (57.84%), Query Frame = 3
Query: 39 PDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRE-LLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF-DIXXXXXXXXXXXXQPVQKS----KISVTENVFYRI--------------------------------TLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS 1373
P A+ PI WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDIIK + + +GVL+E+ IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + KS++RE L+ K+L+ P +R +K + P K+ G+W + D + ++ S D +KS +I+ N+ RI RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL +++ +P T + F L S
Sbjct: 12 PPAAQPI-GWPICRDSYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNIVTYYTSFVVKEELWLVMKLLSGGSMLDIIKHVVGRGEHKNGVLEESIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSSFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKCKFFQ-KSKNREYLIEKLLIK-----TPNIALRGKKVRRVPGSSGHLHKNEDGDWEWSDDELEEKSSEFKDSYSKEKSAFSPQITTDSNMQTRIQNLSLQDTQVRNGIALPIYLSFEFLYNLNVWSVFFFRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKMIDDPLTYKSLTFKLVS 486
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Match: hipk3 (homeodomain interacting protein kinase 3 [Source:Xenbase;Acc:XB-GENE-1010053]) HSP 1 Score: 336.265 bits (861), Expect = 1.070e-108 Identity = 204/491 (41.55%), Postives = 284/491 (57.84%), Query Frame = 3
Query: 39 PDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRE-LLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF-DIXXXXXXXXXXXXQPVQKS----KISVTENVFYRI--------------------------------TLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNS 1373
P A+ PI WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDIIK + + +GVL+E+ IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + KS++RE L+ K+L+ P +R +K + P K+ G+W + D + ++ S D +KS +I+ N+ RI RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL +++ +P T + F L S
Sbjct: 43 PPAAQPI-GWPICRDSYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNIVTYYTSFVVKEELWLVMKLLSGGSMLDIIKHVVGRGEHKNGVLEESIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSSFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKCKFFQ-KSKNREYLIEKLLIK-----TPNIALRGKKVRRVPGSSGHLHKNEDGDWEWSDDELEEKSSEFKDSYSKEKSAFSPQITTDSNMQTRIQNLSLQDTQVRNGIALPIYLSFEFLYNLNVWSVFFFRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKMIDDPLTYKSLTFKLVS 517
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Match: Stk39 (serine/threonine kinase 39 [Source:MGI Symbol;Acc:MGI:1858416]) HSP 1 Score: 342.043 bits (876), Expect = 1.078e-110 Identity = 210/497 (42.25%), Postives = 289/497 (58.15%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQ-PVQKSKISVTE-------NVFYR-------ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK N+ + +GVL+E IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + K+++RE L + LL P +R KVR DEK E+ S E + +K ++ + S P Q +SV + N YR + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V +P ++ F L S S + E L G+A++
Sbjct: 68 WPICRDAYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ-KAKNREYLIEKLLT-RTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENSEISVNAGGIPEQIQSLSVHDSQAQPNANEDYREGPCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 553
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Match: Oxsr1 (oxidative-stress responsive 1 [Source:MGI Symbol;Acc:MGI:1917378]) HSP 1 Score: 316.235 bits (809), Expect = 3.726e-101 Identity = 157/305 (51.48%), Postives = 206/305 (67.54%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN 980
W N+ DY ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK K + SGVLDE TIATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F + K++++E L + +L
Sbjct: 10 WSINRDDYELQEVIGSGATAVVQAAYCAPKKER-VAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ-KAKNKEFLQEKILQ 306 HSP 2 Score: 58.9214 bits (141), Expect = 1.175e-8 Identity = 38/105 (36.19%), Postives = 63/105 (60.00%), Query Frame = 3
Query: 1119 QKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
Q++KI ++ + LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP + R F L S S + + L G+A++
Sbjct: 428 QETKIPIS------LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Match: Stk26 (serine/threonine kinase 26 [Source:MGI Symbol;Acc:MGI:1917665]) HSP 1 Score: 192.971 bits (489), Expect = 1.175e-55 Identity = 110/293 (37.54%), Postives = 168/293 (57.34%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
IG+G+ V++ ++NR A+KII+LE+ + +EI + + + YY S + G++L I+M+ GS LD+++A G DE IAT++K++LKGL Y+H +HRD+K N+L+ + +++ADFGVAG L + KR TFVGTP WMAPEV+QQ Y+ KADIWS+GIT IE+A G+ P + PM+VL L +N+PP + ++ +++F CL KDPS RP+AKELL+ FI S+ L++++
Sbjct: 30 IGKGSFGEVFKG----IDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---------GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQI---------KRNTFVGTPFWMAPEVIQQ-SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------IGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Match: Stk4 (serine/threonine kinase 4 [Source:MGI Symbol;Acc:MGI:1929004]) HSP 1 Score: 195.282 bits (495), Expect = 1.519e-55 Identity = 109/278 (39.21%), Postives = 157/278 (56.47%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKS 938
+G+G+ +VY+A K +I+ +++ + L EI KEI M+ + ++V YY S T+L I+M+ C GS+ DII+ + + L E+ IATI++ LKGL Y+H +HRD+K GN+L+ + ++ADFGVAG L KR T +GTP WMAPEV+Q++ GYN ADIWS+GIT IEMA G+ PYA PM+ + + N PP S+ + + F K CL K P QR +A +LLQ PF+KS
Sbjct: 36 LGEGSYGSVYKAI------HKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-------LRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT---------DTMAKRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMD-------FVKQCLVKSPEQRATATQLLQHPFVKS 283
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Match: Stk26 (serine/threonine kinase 26 [Source:MGI Symbol;Acc:MGI:1917665]) HSP 1 Score: 193.356 bits (490), Expect = 2.026e-55 Identity = 110/293 (37.54%), Postives = 168/293 (57.34%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
IG+G+ V++ ++NR A+KII+LE+ + +EI + + + YY S + G++L I+M+ GS LD+++A G DE IAT++K++LKGL Y+H +HRD+K N+L+ + +++ADFGVAG L + KR TFVGTP WMAPEV+QQ Y+ KADIWS+GIT IE+A G+ P + PM+VL L +N+PP + ++ +++F CL KDPS RP+AKELL+ FI S+ L++++
Sbjct: 30 IGKGSFGEVFKG----IDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---------GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQI---------KRNTFVGTPFWMAPEVIQQ-SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------IGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Match: sp|Q9UEW8|STK39_HUMAN (STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3) HSP 1 Score: 345.125 bits (884), Expect = 3.017e-111 Identity = 210/498 (42.17%), Postives = 290/498 (58.23%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQ-PVQKSKISVTE-------NVFYR--------ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK N+ + +GVL+E IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + K+++RE L + LL P +R KVR DEK E+ FS E + +K ++ + + P Q +SV + N YR + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V +P ++ F L S S + E L G+A++
Sbjct: 56 WPICRDAYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ-KAKNREYLIEKLLT-RTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 542
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Match: sp|Q9Z1W9|STK39_MOUSE (STE20/SPS1-related proline-alanine-rich protein kinase OS=Mus musculus OX=10090 GN=Stk39 PE=1 SV=1) HSP 1 Score: 342.043 bits (876), Expect = 7.540e-110 Identity = 210/497 (42.25%), Postives = 289/497 (58.15%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQ-PVQKSKISVTE-------NVFYR-------ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK N+ + +GVL+E IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + K+++RE L + LL P +R KVR DEK E+ S E + +K ++ + S P Q +SV + N YR + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V +P ++ F L S S + E L G+A++
Sbjct: 68 WPICRDAYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ-KAKNREYLIEKLLT-RTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENSEISVNAGGIPEQIQSLSVHDSQAQPNANEDYREGPCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQL 553
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Match: sp|O88506|STK39_RAT (STE20/SPS1-related proline-alanine-rich protein kinase OS=Rattus norvegicus OX=10116 GN=Stk39 PE=1 SV=2) HSP 1 Score: 340.887 bits (873), Expect = 1.778e-109 Identity = 210/499 (42.08%), Postives = 290/499 (58.12%), Query Frame = 3
Query: 60 VQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQ-PVQKSKISVTE-------NVFYR-------ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
V WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK N+ + +GVL+E IATI+K+VL+GL Y+H NG +HRDLK GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KAD+WS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDPS+RP+A ELL+ F + K+++RE L + LL P +R KVR DEK E+ S E + +K ++ + S P Q +SV + N YR + LR RN ++ EL DI F + G+D+ D +++EL A L+DG D+++VA NL ++V +P ++ F L S + + E L G+A++
Sbjct: 63 VGWPICRDAYELQEVIGSGATAVVQAALCKPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ-KAKNREYLIEKLLT-RTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRK--ELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQL 550
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Match: sp|G5EEN4|GCK3_CAEEL (Germinal center kinase 3 OS=Caenorhabditis elegans OX=6239 GN=gck-3 PE=1 SV=1) HSP 1 Score: 326.635 bits (836), Expect = 1.679e-103 Identity = 167/344 (48.55%), Postives = 220/344 (63.95%), Query Frame = 3
Query: 54 PIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIK---ATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN--CDIPPAPERKVRDEKQEKNPKDFSGEWNFD 1070
P +WP S Y + SIG GAT+TV+ A C + N K A+K INLEKC +S +DE+ EI+ M + N+V+YY S +A EL ++M L GS+LDI+K K GVLDE +IAT++++VLKGL Y H NG +HRD+K GN+L+ DD IQIADFGV+G+LA+ +S R TFVGTPCWMAPEVM+QV+GY+ KADIWS+GI IE+ATG APY KY PMKVLMLTLQNDPP ++T A +QY YG ++ + CL KDP++RP+A ELL+ F K K +D++ L L+ +P + K KD G W F+
Sbjct: 97 PADRWPTEPSAYKLDESIGVGATATVFTAYC-LPRNEKVAIKCINLEKCQTS--VDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLAS---SGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFK-KGKDKKYLVHTLIENLASVPVVAHHSSKKVASGKLRKDAHGNWEFE 433 HSP 2 Score: 60.077 bits (144), Expect = 3.557e-8 Identity = 39/96 (40.62%), Postives = 57/96 (59.38%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELV----AEPTMRERVFALNSP-PASGVISEADLNGYAKVLL 1433
+ LR RN Q EL DI F+Y D+V+ +A ELV A+L+D DL++VA NL +L+ ++ R FALNS A+ + E L G+A++ L
Sbjct: 501 MVLRVRN--QQRELNDIKFDYTKSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERTLTGFAQISL 594
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Match: sp|Q5R495|OXSR1_PONAB (Serine/threonine-protein kinase OSR1 OS=Pongo abelii OX=9601 GN=OXSR1 PE=2 SV=1) HSP 1 Score: 318.161 bits (814), Expect = 5.636e-101 Identity = 157/305 (51.48%), Postives = 207/305 (67.87%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN 980
W N+ DY ++ IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK K + SGVLDE+TIATI+++VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F + K++++E L + +L
Sbjct: 10 WSINRDDYELQEVIGSGATAVVQAAYC-APKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ-KAKNKEFLQEKILQ 306 HSP 2 Score: 58.9214 bits (141), Expect = 6.443e-8 Identity = 38/105 (36.19%), Postives = 63/105 (60.00%), Query Frame = 3
Query: 1119 QKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP-PASGVISEADLNGYAKV 1427
Q++KI ++ + LR RN K+ EL DI F + G+D+ + +++EL+ A L+DG DL++VA NL ++V EP + R F L S S + + L G+A++
Sbjct: 428 QETKIPIS------LVLRLRNSKK--ELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQL 524
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Match: A0A4S2LUR6 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006110 PE=4 SV=1) HSP 1 Score: 517.694 bits (1332), Expect = 7.439e-176 Identity = 248/350 (70.86%), Postives = 286/350 (81.71%), Query Frame = 3
Query: 45 ASHP-----IVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVR---DEKQEKNPKDFSGEWNFD 1070
A HP VQWP KS Y SIGQGATSTV+EASCP+ N RKCA+KIINLEKCS+S L+EI +EI+ M+N+KNENIV YYAS V TELCI+MDLCQRGSLLD+IK TQ+KRDIS GV DENTIATI++DVL+GL+YIHENGLVHRDLKCGNLLVKDD VIQIADFGVAGFLA +P+ AT S+D +RFTFVGTPCWMAPEVMQQ +GYNQKADIWS+GIT IEMATGQAPYAKY PMKVLMLTLQNDPPDIDT A SNQY NYG K+RKFT+ CL KDP QR SA+ELL +IK+K++DRELL +++L +IPP R + D +++ PK+ S EWNFD
Sbjct: 8 APHPGSLESPVQWPMTKSSYDFGKSIGQGATSTVFEASCPV-NGRKCAIKIINLEKCSTSASLEEINREIKSMKNMKNENIVAYYASFVDQTELCIVMDLCQRGSLLDVIKYTQSKRDISYGVFDENTIATILRDVLRGLAYIHENGLVHRDLKCGNLLVKDDGVIQIADFGVAGFLATQPLTATD-SVDLRRFTFVGTPCWMAPEVMQQARGYNQKADIWSLGITTIEMATGQAPYAKYAPMKVLMLTLQNDPPDIDTVATVSNQYINYGQKFRKFTRACLMKDPGQRLSARELLSHTYIKAKAKDRELLCRVMLGGEIPPPISRSNKHADDRSEKRGPKNNSTEWNFD 355 HSP 2 Score: 80.8777 bits (198), Expect = 2.641e-12 Identity = 38/40 (95.00%), Postives = 38/40 (95.00%), Query Frame = 3
Query: 1155 YRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEA 1274
YRITLRKRNPKQNNELQDISFNYV GKDS DVLARELVEA
Sbjct: 492 YRITLRKRNPKQNNELQDISFNYVPGKDSADVLARELVEA 531
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Match: A0A4S2LV50 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006110 PE=4 SV=1) HSP 1 Score: 518.464 bits (1334), Expect = 9.759e-176 Identity = 248/350 (70.86%), Postives = 286/350 (81.71%), Query Frame = 3
Query: 45 ASHP-----IVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVR---DEKQEKNPKDFSGEWNFD 1070
A HP VQWP KS Y SIGQGATSTV+EASCP+ N RKCA+KIINLEKCS+S L+EI +EI+ M+N+KNENIV YYAS V TELCI+MDLCQRGSLLD+IK TQ+KRDIS GV DENTIATI++DVL+GL+YIHENGLVHRDLKCGNLLVKDD VIQIADFGVAGFLA +P+ AT S+D +RFTFVGTPCWMAPEVMQQ +GYNQKADIWS+GIT IEMATGQAPYAKY PMKVLMLTLQNDPPDIDT A SNQY NYG K+RKFT+ CL KDP QR SA+ELL +IK+K++DRELL +++L +IPP R + D +++ PK+ S EWNFD
Sbjct: 8 APHPGSLESPVQWPMTKSSYDFGKSIGQGATSTVFEASCPV-NGRKCAIKIINLEKCSTSASLEEINREIKSMKNMKNENIVAYYASFVDQTELCIVMDLCQRGSLLDVIKYTQSKRDISYGVFDENTIATILRDVLRGLAYIHENGLVHRDLKCGNLLVKDDGVIQIADFGVAGFLATQPLTATD-SVDLRRFTFVGTPCWMAPEVMQQARGYNQKADIWSLGITTIEMATGQAPYAKYAPMKVLMLTLQNDPPDIDTVATVSNQYINYGQKFRKFTRACLMKDPGQRLSARELLSHTYIKAKAKDRELLCRVMLGGEIPPPISRSNKHADDRSEKRGPKNNSTEWNFD 355 HSP 2 Score: 135.961 bits (341), Expect = 3.050e-30 Identity = 78/102 (76.47%), Postives = 86/102 (84.31%), Query Frame = 3
Query: 1155 YRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVIS-EADLNGYAKVLLRFAHEDLP 1457
YRITLRKRNPKQNNELQDISFNYV GKDS DVLARELVEADLLDGCDLLLVAHN+SEL++ P RERVF LNSPPA G + E++L+GYAKVL+R P
Sbjct: 492 YRITLRKRNPKQNNELQDISFNYVPGKDSADVLARELVEADLLDGCDLLLVAHNMSELISNPGQRERVFPLNSPPAPGQVPVESELHGYAKVLIRLVGSPTP 593
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Match: A0A4E0RBM9 (Serine/threonine-protein kinase OSR1 OS=Fasciola hepatica OX=6192 GN=D915_005022 PE=4 SV=1) HSP 1 Score: 515.768 bits (1327), Expect = 1.785e-174 Identity = 242/344 (70.35%), Postives = 284/344 (82.56%), Query Frame = 3
Query: 48 SHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVR---DEKQEKNPKDFSGEWNFD 1070
+ P VQWP KS + SIGQGATS V+EA CP N+R+CA+KIINLEKCS+S L+EI +EI+ M+N+KNENIV YYAS V TELCI+MDLCQRGSLLD+IK TQ+KRD+S GV DENTIATI++DVL+GL+YIHENGLVHRDLKCGNLLVKDD +IQIADFGVAGFLA +P+ ATG S+D +RFTFVGTPCWMAPEVMQQ +GYNQKADIWS+GIT IEMATGQAPYAKY PMKVLMLTLQNDPPDIDT A SNQY NYG K+RKFT+ CL KDP QR SA+ELL +IK+K++DRELL ++LL +IPP R + D + ++PK+ S EWNFD
Sbjct: 13 TEPAVQWPMTKSAFEFGKSIGQGATSVVFEALCPA-NSRRCAIKIINLEKCSTSASLEEINREIKSMKNMKNENIVAYYASFVDATELCIVMDLCQRGSLLDVIKYTQSKRDVSYGVFDENTIATILRDVLRGLAYIHENGLVHRDLKCGNLLVKDDGIIQIADFGVAGFLATQPLTATG-SVDLRRFTFVGTPCWMAPEVMQQARGYNQKADIWSLGITTIEMATGQAPYAKYAPMKVLMLTLQNDPPDIDTVATVSNQYINYGQKFRKFTRACLLKDPGQRLSARELLGHTYIKAKAKDRELLCRVLLGGEIPPPVTRISKHSDDRTERRDPKNNSTEWNFD 354 HSP 2 Score: 132.109 bits (331), Expect = 6.910e-29 Identity = 77/102 (75.49%), Postives = 86/102 (84.31%), Query Frame = 3
Query: 1155 YRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVIS-EADLNGYAKVLLRFAHEDLP 1457
YRITLRKRN KQNNELQDISFNYV GKDS DVLARELVEADLLDGCDLLLVAHN+SEL++ P RERVF LNSPPA G + E++L+GYAKVL+R +P
Sbjct: 503 YRITLRKRNLKQNNELQDISFNYVPGKDSADVLARELVEADLLDGCDLLLVAHNMSELISNPAARERVFPLNSPPAPGQVPVESELHGYAKVLIRLVGSPVP 604
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Match: A0A504YNK3 (Serine/threonine-protein kinase OSR1 OS=Fasciola gigantica OX=46835 GN=FGIG_03036 PE=4 SV=1) HSP 1 Score: 515.768 bits (1327), Expect = 1.804e-174 Identity = 242/344 (70.35%), Postives = 284/344 (82.56%), Query Frame = 3
Query: 48 SHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVR---DEKQEKNPKDFSGEWNFD 1070
+ P VQWP KS + SIGQGATS V+EA CP N+R+CA+KIINLEKCS+S L+EI +EI+ M+N+KNENIV YYAS V TELCI+MDLCQRGSLLD+IK TQ+KRD+S GV DENTIATI++DVL+GL+YIHENGLVHRDLKCGNLLVKDD +IQIADFGVAGFLA +P+ ATG S+D +RFTFVGTPCWMAPEVMQQ +GYNQKADIWS+GIT IEMATGQAPYAKY PMKVLMLTLQNDPPDIDT A SNQY NYG K+RKFT+ CL KDP QR SA+ELL +IK+K++DRELL ++LL +IPP R + D + ++PK+ S EWNFD
Sbjct: 13 TEPAVQWPMTKSAFEFGKSIGQGATSVVFEALCPA-NSRRCAIKIINLEKCSTSASLEEINREIKSMKNMKNENIVAYYASFVDATELCIVMDLCQRGSLLDVIKYTQSKRDVSYGVFDENTIATILRDVLRGLAYIHENGLVHRDLKCGNLLVKDDGIIQIADFGVAGFLATQPLTATG-SVDLRRFTFVGTPCWMAPEVMQQARGYNQKADIWSLGITTIEMATGQAPYAKYAPMKVLMLTLQNDPPDIDTVATVSNQYINYGQKFRKFTRACLLKDPGQRLSARELLGHTYIKAKAKDRELLCRVLLGGEIPPPVTRISKHSDDRTERRDPKNNSTEWNFD 354 HSP 2 Score: 132.109 bits (331), Expect = 6.294e-29 Identity = 77/102 (75.49%), Postives = 86/102 (84.31%), Query Frame = 3
Query: 1155 YRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVIS-EADLNGYAKVLLRFAHEDLP 1457
YRITLRKRN KQNNELQDISFNYV GKDS DVLARELVEADLLDGCDLLLVAHN+SEL++ P RERVF LNSPPA G + E++L+GYAKVL+R +P
Sbjct: 503 YRITLRKRNLKQNNELQDISFNYVPGKDSADVLARELVEADLLDGCDLLLVAHNMSELISNPAARERVFPLNSPPAPGQVPVESELHGYAKVLIRLVGSPVP 604
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Match: A0A4Z2CQZ5 (Serine/threonine-protein kinase OSR1 isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_008286 PE=4 SV=1) HSP 1 Score: 513.457 bits (1321), Expect = 1.952e-173 Identity = 244/340 (71.76%), Postives = 285/340 (83.82%), Query Frame = 3
Query: 60 VQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVRDEKQEK-NPKDFSGEWNFD 1070
+QWP K+ Y SIGQGATS V+EA CP N +KCA+KIINLEKCS+S L+EI +EI+ MRN+KNENIV YYAS VA TELCI+MDLCQRGSLLD+IK TQNKRDI+ GV DENTIATI++DVL+GLSYIHENGLVHRDLKCGNLLVKDD +IQIADFGVAGFLA +P+ ATG S+D +R+TFVGTPCWMAPEVMQQ +GYNQKADIWS+GIT IEMATGQAPYAK+ PMKVLMLTLQND PDID+ A +NQY NYGHK+RKFTK CL KDP+QR SA+ELL +IKSK++DRELL ++LL ++PP R K D++ EK +PK+ S EWNFD
Sbjct: 17 IQWPMTKASYEFGKSIGQGATSIVFEALCPS-NGKKCAIKIINLEKCSTSASLEEINREIKSMRNMKNENIVAYYASFVAQTELCIIMDLCQRGSLLDVIKYTQNKRDITYGVFDENTIATILRDVLRGLSYIHENGLVHRDLKCGNLLVKDDGIIQIADFGVAGFLATQPLTATG-SVDLRRYTFVGTPCWMAPEVMQQARGYNQKADIWSLGITTIEMATGQAPYAKFAPMKVLMLTLQNDSPDIDSVATVNNQYLNYGHKFRKFTKACLMKDPAQRLSARELLGHTYIKSKAKDRELLCRVLLGGEMPPPITRVNKHPDDRSEKRDPKNNSTEWNFD 354 HSP 2 Score: 133.265 bits (334), Expect = 2.974e-29 Identity = 76/96 (79.17%), Postives = 85/96 (88.54%), Query Frame = 3
Query: 1155 YRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVIS-EADLNGYAKVLLRF 1439
YRITLRKRNPKQNNELQDISFNYV GKDS DVLARELVEADLLDGCDLLLVAH++SEL++ P RERVF LNSPPA G + E++L+GYAKVL+R
Sbjct: 520 YRITLRKRNPKQNNELQDISFNYVPGKDSADVLARELVEADLLDGCDLLLVAHHMSELISNPGARERVFPLNSPPAPGQVPIESELHGYAKVLIRI 615
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Match: oxsr1b (oxidative stress responsive kinase 1 [Source:NCBI gene;Acc:103043241]) HSP 1 Score: 348.977 bits (894), Expect = 1.585e-114 Identity = 208/478 (43.51%), Postives = 285/478 (59.62%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNFDIXXXXXXXXXXXX---------------QPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSP-PASGVISEADLNGYAKV 1427
W K DY ++ IG GAT+ V A C + K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LD+IK ++ + +GVLDE +IATI+K+VL+GL Y+H+NG +HRDLK GN+L+ +D +QIADFGV+ FL+ ++ + R TFVGTPCWMAPEVM+QVKGY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG RK +CL KDP +RP++ ELL+ F + K+++ E L + LL AP R +K + P K GEW + D++S G V KS I ++F + L RN K+ EL DI F ++ G+D+ D +++ELV A L+DG DL++VA NL ++V EP + V F L S S + + L G+A++
Sbjct: 10 WSICKDDYELQEVIGSGATAVVQAAYC-VPRKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDVIKHIISRGEHKTGVLDEASIATILKEVLQGLEYLHKNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLST----GGDITRNKVRKTFVGTPCWMAPEVMEQVKGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGITDKEMVKKYGKSLRKMVSLCLQKDPEKRPTSLELLKHKFFQ-KAKNNEFLQEKLLQ----KAPTISERSKKVRRVPGSSGRLHKTEDGEWEWSDDELDEESEEGKAAVAALRVKLDLLFLKAQVCKSLIRKASDLF-SLFLFARNLKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDLVIVAANLQKIVDEPQTNKNVTFKLASGVEGSEIPDDVKLMGFAQL 472
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Match: stk39 (serine/threonine kinase 39 [Source:NCBI gene;Acc:103028154]) HSP 1 Score: 339.732 bits (870), Expect = 1.226e-110 Identity = 206/496 (41.53%), Postives = 290/496 (58.47%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKN-------------PKDFSGEWNF-DIXXXXXXXXXXXXQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSPPASGVI-SEADLNGYAKV 1427
WP K Y ++ IG GAT+ V A C R A+K INLEKC +S ++E+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK T ++ + +GVLDE TIA+I+K+VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL KDP++RP+A ELL+ F + K+++RE L + LL C P +R KVR DE+ E+ ++ GE N ++ + QP++K+ +V + LR RN ++ EL DI F + G+D+ D +++EL A L++G D+++VA NL ++V +P T + F L S S I E L G+A++
Sbjct: 22 WPIVKEAYELQEVIGSGATAVVQAALCTPRQER-VAVKRINLEKCQTS--MEELLKEIQAMSQCNHPNVVTYYTSFVVKDELWLVMKLLSGGSVLDIIKHTCSRGEHKNGVLDEPTIASILKEVLEGLDYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRHKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPMLETGVEDKEMLKKYGKSFRKLITLCLQKDPAKRPTASELLKCKFFQ-KAKNREYLVEKLL-CKGPNISQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDERSEEGKAAVNQGRSRRVKEENQDGEVNANNVPIESLSIQHPQVQPLEKNPNTVGA---VNMVLRLRNSRK--ELNDIRFEFTPGQDTADGVSQELFSAGLVNGHDVIVVAANLQKIVEDPVTYKVLTFKLASGCDSTEIPDEVKLIGFAQL 503
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Match: stk39 (serine/threonine kinase 39 [Source:NCBI gene;Acc:103028154]) HSP 1 Score: 337.806 bits (865), Expect = 4.252e-109 Identity = 200/478 (41.84%), Postives = 281/478 (58.79%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR------------------------DEKQEKN-------------PKDFSGEWNF-DIXXXXXXXXXXXXQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSP 1376
WP K Y ++ IG GAT+ V A C R A+K INLEKC +S ++E+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK T ++ + +GVLDE TIA+I+K+VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL KDP++RP+A ELL+ F + K+++RE L + LL C P +R KVR DE+ E+ ++ GE N ++ + QP++K+ +V + LR RN ++ EL DI F + G+D+ D +++EL A L++G D+++VA NL ++V +P T + F L P
Sbjct: 22 WPIVKEAYELQEVIGSGATAVVQAALCTPRQER-VAVKRINLEKCQTS--MEELLKEIQAMSQCNHPNVVTYYTSFVVKDELWLVMKLLSGGSVLDIIKHTCSRGEHKNGVLDEPTIASILKEVLEGLDYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRHKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPMLETGVEDKEMLKKYGKSFRKLITLCLQKDPAKRPTASELLKCKFFQ-KAKNREYLVEKLL-CKGPNISQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDERSEEGKAAVNQGRSRRVKEENQDGEVNANNVPIESLSIQHPQVQPLEKNPNTVGA---VNMVLRLRNSRK--ELNDIRFEFTPGQDTADGVSQELFSAGLVNGHDVIVVAANLQKIVEDPVTYKVLTFKLVLP 485
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Match: oxsr1b (oxidative stress responsive kinase 1 [Source:NCBI gene;Acc:103043241]) HSP 1 Score: 312.383 bits (799), Expect = 9.040e-100 Identity = 164/341 (48.09%), Postives = 217/341 (63.64%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
W K DY ++ IG GAT+ V A C + K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LD+IK ++ + +GVLDE +IATI+K+VL+GL Y+H+NG +HRDLK GN+L+ +D +QIADFGV+ FL+ ++ + R TFVGTPCWMAPEVM+QVKGY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG RK +CL KDP +RP++ ELL+ F + K+++ E L + LL AP R +K + P K GEW +
Sbjct: 10 WSICKDDYELQEVIGSGATAVVQAAYC-VPRKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDVIKHIISRGEHKTGVLDEASIATILKEVLQGLEYLHKNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLST----GGDITRNKVRKTFVGTPCWMAPEVMEQVKGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGITDKEMVKKYGKSLRKMVSLCLQKDPEKRPTSLELLKHKFFQ-KAKNNEFLQEKLLQ----KAPTISERSKKVRRVPGSSGRLHKTEDGEWEW 338 HSP 2 Score: 58.9214 bits (141), Expect = 7.711e-9 Identity = 37/91 (40.66%), Postives = 57/91 (62.64%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSP-PASGVISEADLNGYAKV 1427
+ LR RN K+ EL DI F ++ G+D+ D +++ELV A L+DG DL++VA NL ++V EP + V F L S S + + L G+A++
Sbjct: 426 LVLRLRNLKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDLVIVAANLQKIVDEPQTNKNVTFKLASGVEGSEIPDDVKLMGFAQL 514
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Match: stk39 (serine/threonine kinase 39 [Source:NCBI gene;Acc:103028154]) HSP 1 Score: 311.227 bits (796), Expect = 3.315e-99 Identity = 162/319 (50.78%), Postives = 214/319 (67.08%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER--KVR 1016
WP K Y ++ IG GAT+ V A C R A+K INLEKC +S ++E+ KEI+ M + N+VTYY S V EL ++M L GS+LDIIK T ++ + +GVLDE TIA+I+K+VL+GL Y+H+NG +HRD+K GN+L+ +D +QIADFGV+ FLA ++ R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL KDP++RP+A ELL+ F + K+++RE L + LL C P +R KVR
Sbjct: 22 WPIVKEAYELQEVIGSGATAVVQAALCTPRQER-VAVKRINLEKCQTS--MEELLKEIQAMSQCNHPNVVTYYTSFVVKDELWLVMKLLSGGSVLDIIKHTCSRGEHKNGVLDEPTIASILKEVLEGLDYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDVTRHKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPMLETGVEDKEMLKKYGKSFRKLITLCLQKDPAKRPTASELLKCKFFQ-KAKNREYLVEKLL-CKGPNISQRAKKVR 331
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Match: stk39 (serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GENE-140106-194]) HSP 1 Score: 232.646 bits (592), Expect = 8.717e-72 Identity = 107/195 (54.87%), Postives = 143/195 (73.33%), Query Frame = 3
Query: 396 VLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN 980
VL+E IA+I+K+VL+GL Y+H NG +HRD+K GN+L+ +D IQIADFGV+ FLA ++ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT +E+A+G APY KY PMKVLMLTLQNDPP ++T YG +RK CL KDP++RP+A ELL+S F + K++++E L++ LL+
Sbjct: 1 VLEEPVIASILKEVLEGLDYLHRNGQIHRDVKAGNILLGEDGTIQIADFGVSAFLAT----GGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAMELASGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMVKKYGKSFRKLISQCLQKDPAKRPTAAELLKSKFFQ-KAKNKEYLAEKLLH 190
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 189.504 bits (480), Expect = 1.225e-54 Identity = 110/295 (37.29%), Postives = 171/295 (57.97%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLK--CGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
IG+G+ V++ ++NR A+KII+LE+ + +EI + + + Y+ S + GT+L I+M+ GS LD+IK G L+E+ IATI++++LKGL Y+H +HRD+K N+L+ + +++ADFGVAG L + KR TFVGTP WMAPEV++Q Y+ KADIWS+GIT IE+A G+ P ++ PM+VL L +N+PP ++ NY +++F CL KDP RP+AKELL+ FI+ ++ L++++
Sbjct: 32 IGKGSFGEVFKG----IDNRTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLIKP---------GPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQI---------KRNTFVGTPFWMAPEVIKQ-SAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLE---------GNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELI 292
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010511.1 (pep scaffold:Pmarinus_7.0:GL476756:358747:414819:1 gene:ENSPMAG00000009510.1 transcript:ENSPMAT00000010511.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 171.4 bits (433), Expect = 7.379e-46 Identity = 107/297 (36.03%), Postives = 161/297 (54.21%), Query Frame = 3
Query: 171 AMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEV--MQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQND--PPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFI---KSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP 1040
A+K+I LE T+ I++EI M+ ++ NIV Y+ S + +L I M+ C GSL DI T G L E IA + ++ LKGL+Y+H +HRD+K N+L+ D +++ADFGV+ + A KR +F+GTP WMAPEV +++ GYNQ+ D+W++GIT IE+A Q P PM+ L L +++ PP + S + N F K L K+P +RP+A +LLQ PF+ ++S ELL +M PAP R D+++ + P
Sbjct: 13 AIKVIKLESGDDFTV---IQQEIIMMQECQHINIVAYFGSYLRWDKLWICMEYCGGGSLQDIYHVT--------GPLSERQIAYVSRETLKGLAYLHSKCKMHRDIKGANILLTDHGEVKLADFGVSAQITAT---------IAKRMSFIGTPYWMAPEVAAVERKGGYNQQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPRLKDKVKWSGIFHN-------FIKQSLIKNPKKRPTADKLLQDPFVIQPLNRSLATELLDQMK-----SPAPPRNFYDDEEPEPP 277
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865]) HSP 1 Score: 169.088 bits (427), Expect = 4.951e-45 Identity = 103/305 (33.77%), Postives = 165/305 (54.10%), Query Frame = 3
Query: 78 KSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEV--MQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQN--DPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIK---SKSRDRELLSKM 971
+ D+ + +G G V++A + A+KII LE ++ I++EI M+ K+ NIV YY S + +L I M+ C GSL DI T G L E IA + ++ L+GL+Y+H G +HRD+K N+L+ DD +++ADFGV+ + A KR +F+GTP WMAPEV +++ GYN + D+W++GIT IE+A Q P PM+ L L ++ PP + S + N F K+ L K+P +RP+A+++L +++ S+++ ELL ++
Sbjct: 11 QEDFELAERLGSGTYGDVHKARN-VQTGELVAIKIIKLEPGDDFSV---IQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVT--------GPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITA---------TIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHN-------FIKMALTKNPKKRPTAEKMLTHSYVQQPLSRAQALELLERV 287
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69]) HSP 1 Score: 155.606 bits (392), Expect = 8.294e-41 Identity = 100/292 (34.25%), Postives = 155/292 (53.08%), Query Frame = 3
Query: 69 PNNKSDYI---IKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIK 935
P + S+Y+ IK IG+G+T V A + R+ A+K ++L K LL E+ MR +EN+V Y S + EL ++M+ + G+L DI+ T+ ++E IAT+ VL+ L+Y+H G++HRD+K ++L+ D I+++DF GF A E T +R + VGTP WMAPEV+ ++ Y + D+WS+GI VIEM G+ PY P++ + N PP + +S R F L +DP+ R +A ELLQ PF++
Sbjct: 412 PGDPSEYLENFIK--IGEGSTGVVCLA-VDRRSGRQVAVKKMHLRKQQRRELL---FNEVVIMREYHHENVVDMYNSYLVADELWVVMEFLEGGALTDIVTHTR---------MNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDF---GFCAQVSKEVT------RRKSLVGTPYWMAPEVISRLP-YGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPL-------LRGFLDQMLVRDPALRATALELLQHPFLQ 671
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 168.703 bits (426), Expect = 1.084e-46 Identity = 101/285 (35.44%), Postives = 153/285 (53.68%), Query Frame = 3
Query: 87 YIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQ-QVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKS 938
Y I+ IG+G VY+A + A+K++NLE L + +EI + LK+ I Y A+++ + I+M+ C GS D++K R +G L E ++ I+ +V GL Y+HE +HRD+K N+L+ ++ ++++ DFGV+G + + KR TFVGTP WMAPEV+ +V GYN+KADIWS+GIT E+ G P +KY PMKV+ + PP + + + F CL K P+ RPSA LL F+K+
Sbjct: 18 YSIQSCIGRGNFGDVYKA-VDRVTQEIVAIKVVNLEHSDEDIEL--LAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLK-----RSYVNG-LPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTL----------KRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGP---------FSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKN 274
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 171.014 bits (432), Expect = 9.016e-46 Identity = 100/297 (33.67%), Postives = 166/297 (55.89%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKN-ENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRD-----RELLSKMLL 977
IG+G VY+ + R A+K++NL+ S S ++++++EI+ + +LK NI YY S + T L I+M+ C GSL +++ G +DE I IM+++L L IH++ ++HRD+K N+L+ ++ +++ DFGVA + SL +R T GTP WMAPEV+ + Y+ K DIWS+GIT E+ATG PY ++ + L +++ PP ++ + Y ++F +CL +DP +R SA +LL+S FI++ +EL+S+ LL
Sbjct: 29 IGRGKFGVVYKGYN-VKTGRVYAIKVLNLD--SDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP---------GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAA-------QVNQTSL--RRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS--------YSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISRYLL 296
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 164.466 bits (415), Expect = 1.530e-43 Identity = 103/288 (35.76%), Postives = 148/288 (51.39%), Query Frame = 3
Query: 69 PNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFI 932
P+ K ++K IGQGA+ VY A I N A+K +NLEK L I EI M+ K+ NIV + S V +L ++M+ + GSL D++ + +L E I + ++ L GL ++H G++HRD+K N+L+ + I++ DFG + L+ KR T VGTP WMAPEV+ + K Y K DIWS+GI +IEM G+ PY TP++ L L N P + + N +KF CLC +P R SA ELL +I
Sbjct: 616 PSTKYANLVK--IGQGASGGVYTA-YEIGTNVSVAIKQMNLEKQPKKEL---IINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVV---------THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQIN---------ELNLKRTTMVGTPYWMAPEVVSR-KEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKL-------KEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYI 871
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 147.902 bits (372), Expect = 1.939e-38 Identity = 93/293 (31.74%), Postives = 146/293 (49.83%), Query Frame = 3
Query: 108 GQGATSTVY----------------EASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYY-ASLVAGTELCILMDLCQRGSLLDIIKAT-QNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFI 932
GQGA+ VY ++ C + + A+K I L + L I E+ M + + ENIV + A ++ EL ++M+ + G L DI+ A ++ S L+EN +A I+K+ +GL ++H ++HRD+K N+L+ +++I DFG L + KR T VGTP WMAPE++ Q KGY++K D+WS+GI +IEM G+ PY P+K L L N P + + S Q ++F CL + R S ++LL F+
Sbjct: 367 GQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQL---IMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEK---------RSKRATMVGTPYWMAPEIVNQ-KGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQ-------TKQFLDACLQVNVESRASVRKLLTFEFL 639
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 147.902 bits (372), Expect = 4.120e-38 Identity = 102/305 (33.44%), Postives = 153/305 (50.16%), Query Frame = 3
Query: 108 GQGATSTVYEAS----------CPILNNR--------KCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYY-ASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLS 965
GQGA+ +VY A ++NN K A+K + L K L I EI M++ +++NIV + A L +L ++M+ + GSL DII+ + D S L E IA I+++ +GL ++H+ ++HRD+K N+L+ A ++I DFG L + KR T VGTP WMAPEV++Q + Y++K D+WS+GI IEM G+ PY P+K L L N P + + S + ++F VCLC D R S +ELL F ++L S
Sbjct: 553 GQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKEL---IVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTN-DNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDK---------RSKRATMVGTPYWMAPEVVKQ-REYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLE-------IKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTS 836
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Match: EDO33129 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST31]) HSP 1 Score: 304.679 bits (779), Expect = 1.651e-97 Identity = 160/318 (50.31%), Postives = 211/318 (66.35%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKA--TQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVM-QQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAA-ASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPER 1007
WPN K DY ++ IG GAT+ V A C N R A+K I+LEKC +S +DE+ KEI M +EN+V YY S V EL I+M L GS+LD+IK Q + GVL+E+ IAT++++VLKGL Y H+NGL+HRD+K GN+L+ D +Q+ADFGV+ ++ + + R TFVGTPCWMAPEVM QQV GYN KADIWS GIT IE+ATG APYAK+ MKVLMLTLQNDPP ++T A S+ Y Y ++K +CL K+P+ RP A ELL++PF K K++ ++ LS+ L+ +PP ER
Sbjct: 9 WPNTKDDYKLQEVIGYGATAVVQAAICESKNER-VAIKRIDLEKCGAS--IDEMMKEIHAMSQCNHENVVNYYTSFVVRQELWIVMRLLNGGSMLDVIKQRIKQQPGLVDEGVLEEDIIATVLREVLKGLEYFHKNGLIHRDVKAGNILLATDGSVQLADFGVSSAIS----DYGDRTKPKMRKTFVGTPCWMAPEVMEQQVHGYNHKADIWSFGITAIELATGTAPYAKFPAMKVLMLTLQNDPPRMETCADGSTRDYKKYSKVFKKMVSLCLQKEPANRPDANELLKNPFFK-KAKGKDYLSEALVPL-MPPLGER 317 HSP 2 Score: 66.2402 bits (160), Expect = 1.271e-11 Identity = 39/93 (41.94%), Postives = 58/93 (62.37%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSPPASGVISEADLNGYAKVLLR 1436
+TLR RN K+ EL DI F++ GKD+ + +A+ELV A L+DG DL++VA NL ++V EP + + F L S S E L G+A++ +
Sbjct: 416 LTLRLRNEKK--ELNDIRFDFTFGKDTAEGVAQELVSAGLIDGQDLVIVAANLQKVVDEPQESKFLTFPLKSSGTSETPDEKALIGFAQLTIH 506
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4]) HSP 1 Score: 190.274 bits (482), Expect = 3.942e-55 Identity = 110/289 (38.06%), Postives = 170/289 (58.82%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRK---CAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELL 962
IG+G+ V++ ++NR A+KII+LE+ + +EI + + + Y+ S + GT+L I+M+ GS LD++KA G ++E IATI+++VLKGL Y+H +HRD+K N+L+ + +++ADFGVAG L +KR TFVGTP WMAPEV++Q Y+ KADIWS+GIT IE+A G+ P + PM+VL L +N+PP++ N+ +++F +CL KDP+ RP+AKELL+ FIK+ ++ L+
Sbjct: 17 IGKGSFGEVFKG----IDNRTNEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKA---------GNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLT---------DTLNKRNTFVGTPFWMAPEVIKQ-SAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELT---------GNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIKTAKKNAYLV 271
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 177.948 bits (450), Expect = 2.904e-51 Identity = 103/290 (35.52%), Postives = 157/290 (54.14%), Query Frame = 3
Query: 105 IGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
+G+G+ +V++A K + +++ +++ T L EI KEI M+ + +V YY S T+L I+M+ C GS+ D++K I + L E I ++K LKGL Y+H +HRD+K GN+L+ + ++ADFGVAG L KR T +GTP WMAPEV+Q+V GY+ ADIWS+GIT +EMA G+ PYA PM+ + + PP + ++ F CL K+P +R +A ELLQ FI+ ++ +LS M+
Sbjct: 30 LGEGSYGSVFKAM------HKESGQVVAIKQVPVDTDLQEIIKEISMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMK-------IRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLT---------DTMAKRNTVIGTPFWMAPEVIQEV-GYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPG-------QWSEDFKDFVSKCLVKNPEERATATELLQHSFIQG-AKQISILSSMI 288
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0]) HSP 1 Score: 167.548 bits (423), Expect = 8.202e-46 Identity = 104/293 (35.49%), Postives = 149/293 (50.85%), Query Frame = 3
Query: 57 IVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIK 935
IV + K Y IGQGA+ TVY A + + A+K +NL + L I EI MR K+ NIV Y S + G EL ++M+ GSL D++ T +DE IA + ++ L+ L ++H NG++HRD+K N+L+ D +++ DFG AT +KR T VGTP WMAPEV+ + K Y + D+WS+GI IEM G+ PY P++ L L N P++ S ++ F L D +R SA+ELLQ PF+K
Sbjct: 216 IVSIGDPKKKYTKFEKIGQGASGTVYTA-IEVATGHEVAIKQMNLSQQPKKEL---IINEILVMRENKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDVVTET---------CMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFC---------ATITPEQNKRSTMVGTPYWMAPEVVTR-KQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPV-------FKDFLAQSLEMDVEKRSSARELLQHPFLK 478
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Match: EDO40961 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T6]) HSP 1 Score: 159.844 bits (403), Expect = 1.427e-44 Identity = 94/257 (36.58%), Postives = 142/257 (55.25%), Query Frame = 3
Query: 225 IKKEIRGMRNLKNE-NIVTYYASLVAGT------ELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVM----QQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKS-KSRDREL 959
IK EI +R N NI TYY + + + +L ++M+ C GS+ D++K +NK L E I+ I ++VL G+S++H N ++HRD+K N+L+ + A +++ DFGV+ L G +R TF+GTP WMAPEV+ Q Y+ + D+WSIGIT IEMA Q P PM+ L L ++DPP + + + S ++ F CL KD RP+A +LLQ FIK +S +R++
Sbjct: 61 IKLEINVLRKFSNHRNIATYYGAFIKKSLQGQDDQLWLVMEFCGAGSVTDLVKTARNK------ALKEEWISYICREVLNGVSHLHMNHVIHRDIKGQNVLLTESAEVKLVDFGVSAQLD----RTIG-----RRNTFIGTPYWMAPEVIACDEQPDATYDNRCDMWSIGITAIEMAESQPPLCDMHPMRALFLIPRSDPPKLKSKKSWSK-------RFHHFVNTCLIKDYQHRPTADQLLQHEFIKDVRSSERKI 295
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Match: stk39 (serine/threonine kinase 39 [Source:NCBI gene;Acc:101156210]) HSP 1 Score: 335.495 bits (859), Expect = 6.959e-109 Identity = 203/500 (40.60%), Postives = 287/500 (57.40%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF---DIXXXXXXXXXXXXQ-------------------------PVQKSKISVTENVFY-----RITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTM-RERVFALNSPPASG-----VISEADLNGYAKV 1427
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDI+K ++K D + L+E IATI+K+VL+GL Y+H NG +HRD+K GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL K+P++RP+A ELL+ FI+ K++++E L + LL+ AP+ R K + P K G+W + ++ ++ + +Q VQ ++ EN + + LR RN K+ EL DI F + G+D+ D +++EL A L++G D+++VA NL ++V PT R F L ASG + E L G+A++
Sbjct: 22 WPITREAYELQEVIGSGATAVVQAALCTPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVTYYTSFVVKDELWLVMTLLSGGSMLDILKH-RSKEDEKNRALEEPIIATILKEVLEGLDYLHRNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPSLETGVEDKEMLKKYGKSFRKLISMCLQKEPAKRPTAAELLKCKFIQ-KAKNKEYLVEKLLSG----APKISQRARKVRRVPGSSGHLHKTEDGDWEWSDDELDEGSEEGKAAVNQGRSRRVKYEAKDNEEDANSVPIEGLSVQHPQVEPYENAAFLKGVVNMVLRLRNSKK--ELNDIRFEFTPGRDTADGVSQELYSAGLVNGLDVVIVAANLQKIVDNPTTYRVLTFKL----ASGCDDTEIPDEVKLIGFAQL 502
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Match: oxsr1b (serine/threonine-protein kinase OSR1 [Source:NCBI gene;Acc:101156367]) HSP 1 Score: 322.783 bits (826), Expect = 6.773e-104 Identity = 169/341 (49.56%), Postives = 216/341 (63.34%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
W N+ DY + IG GAT+ V A C I K A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LD+IK ++ + SGVLDE +IAT++KDVL GL Y+H+NG +HRDLK GN+L+ DD +QIADFGV+ FLAA M+ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK CL KDP +RP++ ELL+ F + K+++ E L LL AP R ++ + P K GEW +
Sbjct: 10 WSINRDDYELHEVIGSGATAVVQAAYC-IPRKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVTYYTSFVVKDELWLVMKLLSGGSMLDVIKHIISRGEHKSGVLDEASIATVLKDVLDGLEYLHKNGQIHRDLKAGNILLGDDGSVQIADFGVSAFLAA----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGITDKEMVKKYGKSFRKMISSCLQKDPEKRPTSLELLKHKFFQ-KAKNHEFLHDRLLQ----KAPTITERSKRVRRVPGSSGRLHKTEDGEWEW 338 HSP 2 Score: 56.9954 bits (136), Expect = 3.368e-8 Identity = 42/109 (38.53%), Postives = 62/109 (56.88%), Query Frame = 3
Query: 1113 PVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSPPASG---VISEADLNGYAKV 1427
P Q S S + LR RN K+ EL DI F ++ G+D+ D +++ELV A L+DG D+++VA NL ++V EP + V F L ASG V + L G+A++
Sbjct: 412 PTQISSSSGNVQSPISLVLRLRNLKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDVVIVAANLQKIVDEPQSNKSVTFKL----ASGTEEVPDDIKLMGFAQL 514
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Match: oxsr1b (serine/threonine-protein kinase OSR1 [Source:NCBI gene;Acc:101156367]) HSP 1 Score: 322.398 bits (825), Expect = 1.086e-103 Identity = 169/341 (49.56%), Postives = 216/341 (63.34%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
W N+ DY + IG GAT+ V A C I K A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LD+IK ++ + SGVLDE +IAT++KDVL GL Y+H+NG +HRDLK GN+L+ DD +QIADFGV+ FLAA M+ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK CL KDP +RP++ ELL+ F + K+++ E L LL AP R ++ + P K GEW +
Sbjct: 10 WSINRDDYELHEVIGSGATAVVQAAYC-IPRKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVTYYTSFVVKDELWLVMKLLSGGSMLDVIKHIISRGEHKSGVLDEASIATVLKDVLDGLEYLHKNGQIHRDLKAGNILLGDDGSVQIADFGVSAFLAA----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGITDKEMVKKYGKSFRKMISSCLQKDPEKRPTSLELLKHKFFQ-KAKNHEFLHDRLLQ----KAPTITERSKRVRRVPGSSGRLHKTEDGEWEW 338 HSP 2 Score: 56.9954 bits (136), Expect = 3.382e-8 Identity = 39/108 (36.11%), Postives = 59/108 (54.63%), Query Frame = 3
Query: 1113 PVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERV-FALNSPPASGVISEADLNGYAKVLL 1433
P Q S S + LR RN K+ EL DI F ++ G+D+ D +++ELV A L+DG D+++VA NL ++V EP + V F L +S+ L Y +L+
Sbjct: 412 PTQISSSSGNVQSPISLVLRLRNLKK--ELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDVVIVAANLQKIVDEPQSNKSVTFKL--------VSQTHLQDYPFILI 509
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Match: oxsr1a (serine/threonine-protein kinase OSR1 [Source:NCBI gene;Acc:101161509]) HSP 1 Score: 314.694 bits (805), Expect = 1.044e-100 Identity = 159/305 (52.13%), Postives = 207/305 (67.87%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLN 980
W +K DY +K IG GAT+ V A C K A+K INLEKC +S +DE+ KEI+ M + NIV+YY S V EL ++M L GS+LDIIK ++ + +GVLDE +IATI+K+VL+GL Y+H+NG +HRDLK GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY KY PMKVLMLTLQNDPP ++T YG +RK +CL KDP +RP+A ELL+ F +K+++ E L ++LL
Sbjct: 10 WSIDKDDYELKEVIGSGATAVVQAAYCKP-RKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIISRGEHKNGVLDEASIATILKEVLEGLEYLHKNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPCLETGITDKEMVKKYGKSFRKMLALCLQKDPEKRPTAAELLKHKFF-TKAKNNEYLHEILLQ 306 HSP 2 Score: 59.6918 bits (143), Expect = 5.045e-9 Identity = 37/88 (42.05%), Postives = 55/88 (62.50%), Query Frame = 3
Query: 1131 ISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEP-TMRERVFALNSPPASGV 1391
++ + V + LR RN K+ EL DI F ++ G+DS D +++ELV A L+DG DL++VA NL ++V +P + R F L ASGV
Sbjct: 422 LAFSSGVPISLVLRLRNSKK--ELNDIRFEFMPGRDSADGVSQELVSAGLVDGRDLVIVAANLQKIVDDPQSNRSVTFKL----ASGV 503
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Match: stk39 (serine/threonine kinase 39 [Source:NCBI gene;Acc:101156210]) HSP 1 Score: 305.449 bits (781), Expect = 7.058e-97 Identity = 162/341 (47.51%), Postives = 218/341 (63.93%), Query Frame = 3
Query: 66 WPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNP-------KDFSGEWNF 1067
WP + Y ++ IG GAT+ V A C R A+K INLEKC +S +DE+ KEI+ M + NIVTYY S V EL ++M L GS+LDI+K ++K D + L+E IATI+K+VL+GL Y+H NG +HRD+K GN+L+ +D +QIADFGV+ FLA M+ + R TFVGTPCWMAPEVM+QV+GY+ KADIWS GIT IE+ATG APY +Y PMKVLMLTLQNDPP ++T YG +RK +CL K+P++RP+A ELL+ FI+ K++++E L + LL+ AP+ R K + P K G+W +
Sbjct: 22 WPITREAYELQEVIGSGATAVVQAALCTPRQER-VAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVTYYTSFVVKDELWLVMTLLSGGSMLDILKH-RSKEDEKNRALEEPIIATILKEVLEGLDYLHRNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT----GGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGSAPYHRYPPMKVLMLTLQNDPPSLETGVEDKEMLKKYGKSFRKLISMCLQKEPAKRPTAAELLKCKFIQ-KAKNKEYLVEKLLSG----APKISQRARKVRRVPGSSGHLHKTEDGDWEW 349 HSP 2 Score: 52.7582 bits (125), Expect = 6.227e-7 Identity = 36/95 (37.89%), Postives = 55/95 (57.89%), Query Frame = 3
Query: 1161 ITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTM-RERVFALNSPPASG-----VISEADLNGYAKV 1427
+ LR RN K+ EL DI F + G+D+ D +++EL A L++G D+++VA NL ++V PT R F L ASG + E L G+A++
Sbjct: 453 MVLRLRNSKK--ELNDIRFEFTPGRDTADGVSQELYSAGLVNGLDVVIVAANLQKIVDNPTTYRVLTFKL----ASGCDDTEIPDEVKLIGFAQL 541
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Match: SMESG000066296.1 (SMESG000066296.1) HSP 1 Score: 975.311 bits (2520), Expect = 0.000e+0 Identity = 484/484 (100.00%), Postives = 484/484 (100.00%), Query Frame = 3
Query: 21 MIDGTAPDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNPKDFSGEWNFDIXXXXXXXXXXXXQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVISEADLNGYAKVLLRFAHEDLPVLPKT 1472
MIDGTAPDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNPKDFSGEWNFDIKGKDDDSSSGDDQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVISEADLNGYAKVLLRFAHEDLPVLPKT
Sbjct: 1 MIDGTAPDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEKQEKNPKDFSGEWNFDIKGKDDDSSSGDDQPVQKSKISVTENVFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVISEADLNGYAKVLLRFAHEDLPVLPKT 484
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Match: SMESG000052774.1 (SMESG000052774.1) HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0 Identity = 345/489 (70.55%), Postives = 402/489 (82.21%), Query Frame = 3
Query: 12 LYVMIDGTAPDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKMLLNCDIPPAPERKVRDEK--QEKNP-KDFSGEWNFDIX-XXXXXXXXXXXQPVQKSKISVTEN---VFYRITLRKRNPKQNNELQDISFNYVLGKDSVDVLARELVEADLLDGCDLLLVAHNLSELVAEPTMRERVFALNSPPASGVISEADLNGYAKVLLRFAHEDLP 1457
L + D A D S+ + W N + DY I SIGQGATS VYEA C LNNR CAMKIINLEKC+SS+LL+EIK+EI+ M+N+KNENIVTYYAS V G EL I+MD+CQRGSLLDIIK TQ+KRDI+ GV DE+TIATI+KDVL+GL+YIHENGLVHRDLKCGNLLVKDD +IQIADFGVA FLAA+PM TG SLD+KRFTFVGTPCWMAPEVMQQVKG+NQKADIWS+GIT IE+A GQAPYAKY PMKVLMLTLQN+ PDIDTAA+S NQY+NYG KYRKF+K CL KDP+ RPSAKELLQSPFIKSK++DR+ L K+LL+ D P ER+ DE EK P K FSGEWNFD++ D + + + V K++ EN + YRITLRKRNPK+NNEL+DISF+YV+GKDSV++L RELVEADLLDGCDLLLVAHN+SELVA P++RERVFALNSPP++GV +E +L GYAKVLLRF E P
Sbjct: 16 LGTISDSNAVDGSNQTIVWSNKREDYKINRSIGQGATSNVYEAECLPLNNRLCAMKIINLEKCNSSSLLEEIKREIKSMKNMKNENIVTYYASFVNGIELFIIMDVCQRGSLLDIIKRTQSKRDITYGVFDESTIATILKDVLRGLTYIHENGLVHRDLKCGNLLVKDDGIIQIADFGVAAFLAAQPMHTTGASLDNKRFTFVGTPCWMAPEVMQQVKGHNQKADIWSLGITAIELAAGQAPYAKYAPMKVLMLTLQNESPDIDTAASSCNQYSNYGQKYRKFSKACLNKDPAMRPSAKELLQSPFIKSKAKDRDSLIKVLLSEDTLPF-ERQRSDENLCPEKTPTKAFSGEWNFDLQPLGDHLNDIDNKESVDKTENETFENSEPISYRITLRKRNPKKNNELEDISFDYVIGKDSVELLVRELVEADLLDGCDLLLVAHNMSELVANPSVRERVFALNSPPSTGVANEQELYGYAKVLLRFFGEPKP 503
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Match: SMESG000018196.1 (SMESG000018196.1) HSP 1 Score: 183.726 bits (465), Expect = 1.399e-51 Identity = 106/277 (38.27%), Postives = 156/277 (56.32%), Query Frame = 3
Query: 87 YIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELL 917
+ I+ +G+G+ +VY+A N A K++ ++ + L +I KEI M+ K++ IV YY S +L I+M+ C GS+ DI++ + + +E IA I++ LKGL YIH+ +HRD+K GN+L+ +D ++ADFGVAG L+ KR T +GTP WMAPEV+Q++ GY+ ADIWS+GIT IEMA G+ PYA PM+ L + PP + + S + N F CL K+P QRPSA +LL
Sbjct: 17 FQIESKLGKGSYGSVYKAKHK-KNGFTVAAKLVPVD-----SELSDIVKEISIMQQCKSDYIVQYYGSFYDSHDLWIVMEYCGAGSVSDIMR-------LRNKTCNEEEIAIILQGSLKGLEYIHQLKKIHRDIKAGNILLTEDGNAKLADFGVAGQLSDTLA---------KRNTVIGTPYWMAPEVIQEI-GYHYSADIWSLGITAIEMADGKPPYADIHPMRALFMIPSQPPPTLLNPSIWSPSFVN-------FITQCLVKNPDQRPSASQLL 263
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Match: SMESG000010489.1 (SMESG000010489.1) HSP 1 Score: 180.259 bits (456), Expect = 6.994e-50 Identity = 106/296 (35.81%), Postives = 166/296 (56.08%), Query Frame = 3
Query: 87 YIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIKKEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEVMQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVLMLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
Y + IG+G+ V++ I + A+KII+LE+ + +EI + + + Y+ S + T+L I+M+ GS +D++K G L+E IA I++++LKGL Y+H +HRD+K N+L+ ++ +++ADFGVAG L + +KR TFVGTP WMAPEV++Q Y+ KADIWS+GIT IE+A G+ P++ PM+VL L +N P +D + + +R F CL K+P RPSA+ELL FIK K++ L +++
Sbjct: 18 YDVLERIGKGSFGEVHKGVNKI-DKTIVAIKIIDLEEAEDEIEDIQ--QEINVLSQCDSPYVTKYFGSYLKVTKLWIIMEYLGGGSAMDLMKP---------GPLNETYIAIILREILKGLDYLHSQKKLHRDIKAANVLLSENGDVKLADFGVAGQLT---------NTTNKRVTFVGTPFWMAPEVIKQ-SAYDFKADIWSLGITAIELAKGEPPHSNLHPMRVLFLIPKNPSPQLDGS---------FSKLFRDFVDCCLNKEPDNRPSARELLHHGFIK-KAKKTAYLQELI 281
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Match: SMESG000029685.1 (SMESG000029685.1) HSP 1 Score: 174.866 bits (442), Expect = 2.630e-46 Identity = 111/305 (36.39%), Postives = 165/305 (54.10%), Query Frame = 3
Query: 78 KSDYIIKGSIGQGATSTVYEASCPILNNRKCAMKIINLEKCSSSTLLDEIK---KEIRGMRNLKNENIVTYYASLVAGTELCILMDLCQRGSLLDIIKATQNKRDISSGVLDENTIATIMKDVLKGLSYIHENGLVHRDLKCGNLLVKDDAVIQIADFGVAGFLAARPMEATGMSLDDKRFTFVGTPCWMAPEV--MQQVKGYNQKADIWSIGITVIEMATGQAPYAKYTPMKVL-MLTLQNDPPDIDTAAASSNQYTNYGHKYRKFTKVCLCKDPSQRPSAKELLQSPFIKSKSRDRELLSKML 974
K DY + +IG G VY+A NN A+KI+ ++ + D+IK +EI +R+ ++NIV Y+ S + +L I M+ C S+ DI T +R L+EN IA + +D L GL+Y+H+ G +HRD+K N+L+ +D ++IADFGVA A KR +F+GTP WMAPEV +++ GY++K DIW++GIT IE A Q P PMK L +L+++N A T + K+ F K+CL K+ +RP A LLQ F+ K+ L +L
Sbjct: 22 KEDYKLIKNIGSGTYGEVYKA-IHRRNNTVSAVKIVKVD------IKDDIKAIAQEIHTLRDCNHKNIVKYFGSYLRKNKLWICMEFCGGFSIQDIY--TNIRRP-----LEENCIAYVTRDTLDGLAYMHKQGKIHRDIKGANILLTEDGQVKIADFGVA---------AQITQTIQKRCSFIGTPYWMAPEVAAVERKGGYDEKCDIWAVGITAIEYAELQPPMFDLHPMKALHLLSMRN------YKAPVLQNKTKWSQKFHSFLKICLNKNEKRRPDAMTLLQHDFVTQKNLTISLTKHLL 297 The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase OSR1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30000705 ID=SMED30000705|Name=Serine/threonine-protein kinase OSR1|organism=Schmidtea mediterranea sexual|type=transcript|length=1651bpback to top protein sequence of SMED30000705-orf-1 >SMED30000705-orf-1 ID=SMED30000705-orf-1|Name=SMED30000705-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=485bp MIDGTAPDASHPIVQWPNNKSDYIIKGSIGQGATSTVYEASCPILNNRKCback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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