Beta-arrestin-1

Overview
NameBeta-arrestin-1
Smed IDSMED30000649
Length (bp)1040
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Beta-arrestin-1 (SMED30000649) t-SNE clustered cells

Violin plots show distribution of expression levels for Beta-arrestin-1 (SMED30000649) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000649

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30000649h1SMcG0021492 dd_Smed_v4_12583_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000649h1SMcG0021492 dd_Smed_v4_12583_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30000649h1SMcG0021492 dd_Smed_v4_12583_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30000649h1SMcG0021492 dd_Smed_v6_12583_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 113.235 bits (282), Expect = 1.145e-27
Identity = 61/144 (42.36%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  168 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 311
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 112.849 bits (281), Expect = 8.161e-27
Identity = 61/144 (42.36%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 112.849 bits (281), Expect = 8.441e-27
Identity = 61/144 (42.36%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  168 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 311
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 103.605 bits (257), Expect = 7.275e-25
Identity = 56/124 (45.16%), Postives = 77/124 (62.10%), Query Frame = -3 
Query:  274 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVL 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL
Sbjct:  168 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVL 291
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 103.605 bits (257), Expect = 1.282e-23
Identity = 57/137 (41.61%), Postives = 81/137 (59.12%), Query Frame = -3 
Query:  214 ISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 615
            I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  121 ILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 257
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Celegans
Match: xpd-1 (XPD (Xeroderma Pigmentosum complementation group D) related [Source:UniProtKB/TrEMBL;Acc:Q9N3L2])

HSP 1 Score: 94.7449 bits (234), Expect = 4.287e-21
Identity = 51/130 (39.23%), Postives = 77/130 (59.23%), Query Frame = -3 
Query:  256 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPG 636
            YF  R  I+  +++VY Y+Y+LD KIA+L++K   +  VV FDE+HNI    IESMS  I++   + A   L SL+    + K  + EKL +EY++LV  L+ T  +   D  LANP   + +L + +PG
Sbjct:  190 YFTARQAINRAHIVVYSYHYILDPKIAELVSKDFSRKSVVVFDEAHNIDNVCIESMSVAISQKNADRALQELQSLEGVVNRMKSSNSEKLQSEYDKLVEGLKRTERERANDERLANPVLPDQILHEAVPG 319
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Celegans
Match: arr-1 (Beta-arrestin arr-1 [Source:UniProtKB/Swiss-Prot;Acc:P51485])

HSP 1 Score: 60.8474 bits (146), Expect = 5.029e-10
Identity = 29/46 (63.04%), Postives = 36/46 (78.26%), Query Frame = 2 
Query:  134 DSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVL 271
            D K GTRVFKK+S NGKIT Y+GKRD+++R D++D ID    GMVL
Sbjct:    5 DKKSGTRVFKKTSPNGKITTYLGKRDFIDRGDYVDLID----GMVL 46
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Fly
Match: Xpd (gene:FBgn0261850 transcript:FBtr0071576)

HSP 1 Score: 103.99 bits (258), Expect = 4.131e-24
Identity = 57/144 (39.58%), Postives = 84/144 (58.33%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R  I+H +++VY Y+YLLD KIA +++K + +   V FDE+HNI    I+SMS  INR T+E + N+L  L    +  +E D  +L  EY  +V  L+  S +   D+ILANP     VL + +PG+  +     SFL +
Sbjct:  192 YFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Fly
Match: krz (gene:FBgn0040206 transcript:FBtr0305268)

HSP 1 Score: 56.6102 bits (135), Expect = 1.634e-8
Identity = 25/42 (59.52%), Postives = 31/42 (73.81%), Query Frame = 2 
Query:  122 ADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
             D    +  TRVFKKSS NGKITVY+GKRD+++   H+DPID
Sbjct:   38 GDASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPID 79
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Fly
Match: krz (gene:FBgn0040206 transcript:FBtr0085877)

HSP 1 Score: 56.6102 bits (135), Expect = 1.634e-8
Identity = 25/42 (59.52%), Postives = 31/42 (73.81%), Query Frame = 2 
Query:  122 ADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
             D    +  TRVFKKSS NGKITVY+GKRD+++   H+DPID
Sbjct:   38 GDASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPID 79
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Match: ercc2 (excision repair cross-complementation group 2 [Source:ZFIN;Acc:ZDB-GENE-040426-997])

HSP 1 Score: 105.916 bits (263), Expect = 1.461e-24
Identity = 60/146 (41.10%), Postives = 88/146 (60.27%), Query Frame = -3 
Query:  220 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS-RSS---IGSM*SFL 636
            YFL R  + H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++    ++ +L+++  + KE D  KL  EY  LV  L+  +     D+ L+NP   + +L + +PGS R++   +G M  FL
Sbjct:  192 YFLARYALLHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVETLQNTISRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEILQEAVPGSIRTAEHFVGFMKRFL 337
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Match: arrb2a (arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131-29])

HSP 1 Score: 59.3066 bits (142), Expect = 2.431e-9
Identity = 24/36 (66.67%), Postives = 31/36 (86.11%), Query Frame = 2 
Query:  140 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            K GTRVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    4 KAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Match: arrb2a (arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131-29])

HSP 1 Score: 59.3066 bits (142), Expect = 2.497e-9
Identity = 24/36 (66.67%), Postives = 31/36 (86.11%), Query Frame = 2 
Query:  140 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            K GTRVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    4 KAGTRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Match: arrb2b (arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426-1332])

HSP 1 Score: 58.5362 bits (140), Expect = 3.563e-9
Identity = 24/36 (66.67%), Postives = 31/36 (86.11%), Query Frame = 2 
Query:  140 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            K GTRVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    4 KAGTRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Match: arrb1 (arrestin, beta 1 [Source:ZFIN;Acc:ZDB-GENE-060824-1])

HSP 1 Score: 52.7582 bits (125), Expect = 3.267e-7
Identity = 24/42 (57.14%), Postives = 34/42 (80.95%), Query Frame = 2 
Query:  146 GTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVL 271
            GTRVFKK+S NGK+TVY+GKRD+++  D ++P+D    G+VL
Sbjct:    5 GTRVFKKASPNGKLTVYLGKRDFVDHVDLVEPVD----GVVL 42
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 108.612 bits (270), Expect = 2.105e-25
Identity = 57/131 (43.51%), Postives = 81/131 (61.83%), Query Frame = -3 
Query:  253 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS 636
            Y+L R+ +   NV+VY Y+YLLD KIADL+++ L K  VV FDE+HNI    I+SMS TI R T+E    ++ +L  +  K KE D++KL  EY +LV  LR  S     D+ L+NP   + +L + +PG 
Sbjct:  192 YYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC 322
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 108.612 bits (270), Expect = 2.211e-25
Identity = 57/131 (43.51%), Postives = 81/131 (61.83%), Query Frame = -3 
Query:  253 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS 636
            Y+L R+ +   NV+VY Y+YLLD KIADL+++ L K  VV FDE+HNI    I+SMS TI R T+E    ++ +L  +  K KE D++KL  EY +LV  LR  S     D+ L+NP   + +L + +PG 
Sbjct:  171 YYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC 301
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 108.612 bits (270), Expect = 2.246e-25
Identity = 57/131 (43.51%), Postives = 81/131 (61.83%), Query Frame = -3 
Query:  253 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS 636
            Y+L R+ +   NV+VY Y+YLLD KIADL+++ L K  VV FDE+HNI    I+SMS TI R T+E    ++ +L  +  K KE D++KL  EY +LV  LR  S     D+ L+NP   + +L + +PG 
Sbjct:  192 YYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC 322
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 100.138 bits (248), Expect = 1.805e-22
Identity = 54/124 (43.55%), Postives = 76/124 (61.29%), Query Frame = -3 
Query:  253 ISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS 615
            +   NV+VY Y+YLLD KIADL+++ L K  VV FDE+HNI    I+SMS TI R T+E    ++ +L  +  K KE D++KL  EY +LV  LR  S     D+ L+NP   + +L + +PG 
Sbjct:  121 LGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC 244
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Match: arr3 (arrestin 3, retinal (X-arrestin) [Source:NCBI gene;Acc:100124859])

HSP 1 Score: 51.2174 bits (121), Expect = 1.056e-6
Identity = 21/40 (52.50%), Postives = 32/40 (80.00%), Query Frame = 2 
Query:  152 RVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVL 271
            RVFKKSS +GK+++Y+ KRDY++  DH++P+D    GM+L
Sbjct:    6 RVFKKSSADGKLSIYLAKRDYVDHVDHVEPVD----GMIL 41
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 111.694 bits (278), Expect = 1.696e-26
Identity = 61/144 (42.36%), Postives = 87/144 (60.42%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++   ++L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 111.694 bits (278), Expect = 1.699e-26
Identity = 61/144 (42.36%), Postives = 87/144 (60.42%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++   ++L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  171 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 314
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 102.449 bits (254), Expect = 2.006e-23
Identity = 57/137 (41.61%), Postives = 82/137 (59.85%), Query Frame = -3 
Query:  214 ISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 615
            I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++   ++L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  123 ILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 259
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Match: Arrb1 (arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473])

HSP 1 Score: 51.6026 bits (122), Expect = 5.662e-8
Identity = 21/33 (63.64%), Postives = 29/33 (87.88%), Query Frame = 2 
Query:  146 GTRVFKKSSLNGKITVYIGKRDYLERNDHIDPI 244
            GTRVFKK+S NGK+TVY+GKRD+++  D +DP+
Sbjct:    5 GTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPV 37
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Match: Arrb2 (arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474])

HSP 1 Score: 54.6842 bits (130), Expect = 7.831e-8
Identity = 26/45 (57.78%), Postives = 34/45 (75.56%), Query Frame = 2 
Query:  137 SKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVL 271
             K GTRVFKKSS N K+TVY+GKRD+++  D +DP+D    G+VL
Sbjct:    3 EKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVD----GVVL 43
[Close]
BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Match: sp|P18074|ERCC2_HUMAN (General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 3.919e-26
Identity = 61/144 (42.36%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Match: sp|Q60452|ERCC2_CRIGR (General transcription and DNA repair factor IIH helicase subunit XPD OS=Cricetulus griseus OX=10029 GN=ERCC2 PE=1 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 6.036e-26
Identity = 61/144 (42.36%), Postives = 87/144 (60.42%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++   ++L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Match: sp|O08811|ERCC2_MOUSE (General transcription and DNA repair factor IIH helicase subunit XPD OS=Mus musculus OX=10090 GN=Ercc2 PE=1 SV=2)

HSP 1 Score: 111.694 bits (278), Expect = 1.186e-25
Identity = 61/144 (42.36%), Postives = 87/144 (60.42%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++   ++L +L+ +  + KE D+++L +EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Match: sp|A6QLJ0|ERCC2_BOVIN (General transcription and DNA repair factor IIH helicase subunit XPD OS=Bos taurus OX=9913 GN=ERCC2 PE=2 SV=1)

HSP 1 Score: 111.309 bits (277), Expect = 1.663e-25
Identity = 61/144 (42.36%), Postives = 85/144 (59.03%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R +I H NV+VY Y+YLLD KIADL++K L +  VV FDE+HNI    I+SMS  + R T++    +L +L+ +  + KE D+++L  EY  LV  LR  S     D  LANP   + VL + +PGS  +      FL +
Sbjct:  192 YFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQANLETLQKTVLRIKETDEQRLREEYRRLVEGLREASAARETDAHLANPVLPDEVLKEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Match: sp|Q8W4M7|ERCC2_ARATH (General transcription and DNA repair factor IIH helicase subunit XPD OS=Arabidopsis thaliana OX=3702 GN=XPD PE=1 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 3.321e-22
Identity = 56/130 (43.08%), Postives = 75/130 (57.69%), Query Frame = -3 
Query:  256 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPG 636
            YFL R+ I   NVIVY Y YLLD K+A  I+K L K  VV FDE+HNI    IE++S ++ R T+E AN +L  ++    + K  D  +L  EYN LV  L +  + S  D  LANP     +L + +PG
Sbjct:  192 YFLARHMIQFANVIVYSYQYLLDPKVAGFISKELQKESVVVFDEAHNIDNVCIEALSVSVRRVTLEGANRNLNKIRQEIDRFKATDAGRLRAEYNRLVEGLALRGDLSGGDQWLANPALPHDILKEAVPG 321
[Close]
BLAST of Beta-arrestin-1 vs. TrEMBL
Match: A0A0V0J9U0 (Helicase ATP-binding domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR108545 PE=4 SV=1)

HSP 1 Score: 122.865 bits (307), Expect = 2.047e-27
Identity = 64/144 (44.44%), Postives = 85/144 (59.03%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R+ I H N++VY YYYLLD KIA L++K  PK  VV FDE+HNI    IESMS  I+R  ++     +  L    ++ KE D  +L  EYN LV  LR  + +   DL+L NPT  + +L + IPG+  S  S  SFL +
Sbjct:  107 YFLARHAIIHANIVVYSYYYLLDPKIASLVSKDFPKNTVVVFDEAHNIDNVCIESMSCVISRRQLDRCQTGIQKLSQRVKEVKERDASQLQQEYNRLVHGLREAANERETDLVLGNPTLPDEILREAIPGTLRSADSFISFLRR 250
[Close]
BLAST of Beta-arrestin-1 vs. TrEMBL
Match: A0A2C9JP28 (Helicase ATP-binding domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106061803 PE=4 SV=1)

HSP 1 Score: 122.865 bits (307), Expect = 2.135e-27
Identity = 64/131 (48.85%), Postives = 83/131 (63.36%), Query Frame = -3 
Query:  253 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGS 636
            YFL R  +S  NVIVY YYYLLD KIADL++K LPK  VV FDE+HNI    +ESMS  I R TI+  N ++  L    R+ K+VD+ +L NEY  +V  LR  +     DL+LANP   + +L + +PGS
Sbjct:  192 YFLARYAMSQANVIVYSYYYLLDPKIADLVSKELPKQSVVVFDEAHNIDNVCVESMSVKITRRTIDKCNQNIEDLSKQIRRIKDVDETRLQNEYQRMVEGLREANIARETDLVLANPVIPDEILQEAVPGS 322
[Close]
BLAST of Beta-arrestin-1 vs. TrEMBL
Match: A0A0V0JBE0 (TFIIH basal transcription factor complex helicase XPD subunit OS=Schistocephalus solidus OX=70667 GN=ERCC2 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 3.012e-27
Identity = 64/144 (44.44%), Postives = 85/144 (59.03%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R+ I H N++VY YYYLLD KIA L++K  PK  VV FDE+HNI    IESMS  I+R  ++     +  L    ++ KE D  +L  EYN LV  LR  + +   DL+L NPT  + +L + IPG+  S  S  SFL +
Sbjct:  107 YFLARHAIIHANIVVYSYYYLLDPKIASLVSKDFPKNTVVVFDEAHNIDNVCIESMSCVISRRQLDRCQTGIQKLSQRVKEVKERDASQLQQEYNRLVHGLREAANERETDLVLGNPTLPDEILREAIPGTLRSADSFISFLRR 250
[Close]
BLAST of Beta-arrestin-1 vs. TrEMBL
Match: A0A0X3NFT2 (Helicase ATP-binding domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR108545 PE=4 SV=1)

HSP 1 Score: 122.865 bits (307), Expect = 3.702e-27
Identity = 64/144 (44.44%), Postives = 85/144 (59.03%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R+ I H N++VY YYYLLD KIA L++K  PK  VV FDE+HNI    IESMS  I+R  ++     +  L    ++ KE D  +L  EYN LV  LR  + +   DL+L NPT  + +L + IPG+  S  S  SFL +
Sbjct:  193 YFLARHAIIHANIVVYSYYYLLDPKIASLVSKDFPKNTVVVFDEAHNIDNVCIESMSCVISRRQLDRCQTGIQKLSQRVKEVKERDASQLQQEYNRLVHGLREAANERETDLVLGNPTLPDEILREAIPGTLRSADSFISFLRR 336
[Close]
BLAST of Beta-arrestin-1 vs. TrEMBL
Match: A0A0X3PDU9 (TFIIH basal transcription factor complex helicase XPD subunit OS=Schistocephalus solidus OX=70667 GN=ERCC2 PE=4 SV=1)

HSP 1 Score: 123.25 bits (308), Expect = 4.266e-27
Identity = 64/144 (44.44%), Postives = 85/144 (59.03%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            YFL R+ I H N++VY YYYLLD KIA L++K  PK  VV FDE+HNI    IESMS  I+R  ++     +  L    ++ KE D  +L  EYN LV  LR  + +   DL+L NPT  + +L + IPG+  S  S  SFL +
Sbjct:  193 YFLARHAIIHANIVVYSYYYLLDPKIASLVSKDFPKNTVVVFDEAHNIDNVCIESMSCVISRRQLDRCQTGIQKLSQRVKEVKERDASQLQQEYNRLVHGLREAANERETDLVLGNPTLPDEILREAIPGTLRSADSFISFLRR 336
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 107.842 bits (268), Expect = 2.440e-25
Identity = 59/144 (40.97%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            Y+L R +I H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++    ++ +L+++ ++ KE D  KL  EY  LV  L+  +     D+ L+NP   + VL + IPGS  +      FL +
Sbjct:  168 YYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKR 311
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 107.842 bits (268), Expect = 2.597e-25
Identity = 59/144 (40.97%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            Y+L R +I H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++    ++ +L+++ ++ KE D  KL  EY  LV  L+  +     D+ L+NP   + VL + IPGS  +      FL +
Sbjct:  192 YYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 100.523 bits (249), Expect = 7.406e-23
Identity = 56/137 (40.88%), Postives = 81/137 (59.12%), Query Frame = -3 
Query:  214 ISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 615
            I H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++    ++ +L+++ ++ KE D  KL  EY  LV  L+  +     D+ L+NP   + VL + IPGS  +      FL +
Sbjct:  104 ILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKR 240
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Match: arrb2a (arrestin red cell [Source:NCBI gene;Acc:103028079])

HSP 1 Score: 56.9954 bits (136), Expect = 1.201e-8
Identity = 24/36 (66.67%), Postives = 30/36 (83.33%), Query Frame = 2 
Query:  140 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            K GTRVFKKSS N KITVY+GKRD+++  D +DP+D
Sbjct:    4 KAGTRVFKKSSPNCKITVYLGKRDFVDHLDQVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Match: arrb2b (arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426-1332])

HSP 1 Score: 52.373 bits (124), Expect = 3.561e-7
Identity = 21/32 (65.62%), Postives = 28/32 (87.50%), Query Frame = 2 
Query:  152 RVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            RVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    8 RVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Sea Lamprey
Match: ercc2 (excision repair cross-complementation group 2 [Source:ZFIN;Acc:ZDB-GENE-040426-997])

HSP 1 Score: 104.76 bits (260), Expect = 5.071e-25
Identity = 63/147 (42.86%), Postives = 88/147 (59.86%), Query Frame = -3 
Query:  214 YFLTR-NTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVL--AKTIPGSRSSIGSM*SFLSK 636
            YFL R + I H NV+VY Y+YLLD KIADL++K + K  VV FDE+HNI    I+SMS  I R T++  + ++ +L+ + +K +E D  KL  EY  LV  LR  S     D+ LANP   + VL  A+ +PG+  +     SFL +
Sbjct:  158 YFLARYSQIMHANVVVYSYHYLLDPKIADLVSKEMSKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCSTNIETLQTTIQKIRETDATKLKEEYRRLVEGLRDASVARETDVHLANPVLPDEVLQDAEAVPGNSRNAEHFVSFLKR 304
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Yeast
Match: RAD3 (5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000973])

HSP 1 Score: 79.7221 bits (195), Expect = 7.324e-17
Identity = 51/154 (33.12%), Postives = 82/154 (53.25%), Query Frame = -3 
Query:  214 ESLLYLYFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLR----VTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 654
            E  L  YF+ R  IS  N+I+Y Y+YLLD KIA+ ++  + K  +V FDE+HNI    IES+S  +  + +  A     +L +   + ++VD +KL +EY +LV  L     +T +   E+  +  P   + +L + IPG+        SFL +
Sbjct:  187 EKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQ---EEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKR 337
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Nematostella
Match: EDO46754 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNX6])

HSP 1 Score: 117.087 bits (292), Expect = 6.598e-29
Identity = 62/130 (47.69%), Postives = 84/130 (64.62%), Query Frame = -3 
Query:  256 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPG 636
            YFL R  I H NVIVY Y+Y+LD KIADL++K L K  VV FDE+HNI    I+SMS TI+R T++ ++ ++ SL     + K  D +KL  EYN LV  LR  SE    D++L+NP   + VL +++PG
Sbjct:  168 YFLARRAIYHANVIVYSYHYMLDPKIADLVSKELDKKAVVVFDEAHNIDNVCIDSMSVTISRRTLDRSHANVESLASVIDRIKATDAQKLREEYNRLVEGLRQASEARDTDIVLSNPVLPDEVLQESVPG 297
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:101163020])

HSP 1 Score: 106.686 bits (265), Expect = 5.934e-25
Identity = 58/144 (40.28%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            Y+L R +I H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++   +++ +L+ + +K K+ D  KL  EY  LV  L+  +     D+ LANP   + +L + +PGS  +      FL +
Sbjct:  192 YYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQSNVETLQHTIQKIKDTDAAKLREEYRRLVEGLKEANVARETDVYLANPVLPDEILQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:101163020])

HSP 1 Score: 106.686 bits (265), Expect = 6.222e-25
Identity = 58/144 (40.28%), Postives = 86/144 (59.72%), Query Frame = -3 
Query:  214 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPGSRSSIGSM*SFLSK 636
            Y+L R +I H N++VY Y+YLLD KIADL++K L K  VV FDE+HNI    I+SMS  I R T++   +++ +L+ + +K K+ D  KL  EY  LV  L+  +     D+ LANP   + +L + +PGS  +      FL +
Sbjct:  192 YYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQSNVETLQHTIQKIKDTDAAKLREEYRRLVEGLKEANVARETDVYLANPVLPDEILQEAVPGSIRTAEHFLGFLRR 335
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Match: arrb2a (arrestin beta 2 [Source:NCBI gene;Acc:101159286])

HSP 1 Score: 58.5362 bits (140), Expect = 3.388e-9
Identity = 24/36 (66.67%), Postives = 31/36 (86.11%), Query Frame = 2 
Query:  140 KGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            K GTRVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    4 KAGTRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Match: arrb2a (arrestin beta 2 [Source:NCBI gene;Acc:101159286])

HSP 1 Score: 52.373 bits (124), Expect = 3.531e-7
Identity = 21/33 (63.64%), Postives = 29/33 (87.88%), Query Frame = 2 
Query:  149 TRVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            +RVFKKSS N K+TVY+GKRD+++  DH+DP+D
Sbjct:    7 SRVFKKSSPNCKLTVYLGKRDFVDHLDHVDPVD 39
[Close]
BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Match: arrb1 (arrestin beta 1 [Source:NCBI gene;Acc:101163309])

HSP 1 Score: 50.447 bits (119), Expect = 1.435e-6
Identity = 20/32 (62.50%), Postives = 28/32 (87.50%), Query Frame = 2 
Query:  152 RVFKKSSLNGKITVYIGKRDYLERNDHIDPID 247
            RVFKK+S NGK+TVY+GKRD+++  D +DP+D
Sbjct:    7 RVFKKASPNGKLTVYLGKRDFVDHVDFVDPVD 38
[Close]
BLAST of Beta-arrestin-1 vs. Planmine SMEST
Match: SMESG000078454.1 (SMESG000078454.1)

HSP 1 Score: 299.671 bits (766), Expect = 5.401e-103
Identity = 152/153 (99.35%), Postives = 152/153 (99.35%), Query Frame = 2 
Query:  119 MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVLAKTYSENVGLARIKSSILFSLVTLRFVTNSLYSFINFSLSTSFVFLSESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK 577
            MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVLAKTYSENVGLARIKSSILFSLV LRFVTNSLYSFINFSLSTSFVFLSESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK
Sbjct:    1 MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVLAKTYSENVGLARIKSSILFSLVILRFVTNSLYSFINFSLSTSFVFLSESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK 153
[Close]
BLAST of Beta-arrestin-1 vs. Planmine SMEST
Match: SMESG000046165.1 (SMESG000046165.1)

HSP 1 Score: 175.252 bits (443), Expect = 4.565e-49
Identity = 91/130 (70.00%), Postives = 105/130 (80.77%), Query Frame = -3 
Query:  256 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPG 636
            YFLTRNTISH N+IVY YYYLLD KIA+L++K LPK  VV FDE+HNI    IESMS TINRNTI+SA+NSL SLKD  R+TKE+DKEKL NEYN+LV NLR+ +E  +EDLILANPT  E VL + IPG
Sbjct:  167 YFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPG 296
[Close]
BLAST of Beta-arrestin-1 vs. Planmine SMEST
Match: SMESG000046165.1 (SMESG000046165.1)

HSP 1 Score: 175.252 bits (443), Expect = 5.278e-49
Identity = 91/130 (70.00%), Postives = 105/130 (80.77%), Query Frame = -3 
Query:  256 YFLTRNTISHENVIVYIYYYLLDRKIADLITKGLPK*FVVNFDESHNI---AIESMSFTINRNTIESANNSLVSLKDSDRKTKEVDKEKLMNEYNELVTNLRVTSEKSIEDLILANPTFSEYVLAKTIPG 636
            YFLTRNTISH N+IVY YYYLLD KIA+L++K LPK  VV FDE+HNI    IESMS TINRNTI+SA+NSL SLKD  R+TKE+DKEKL NEYN+LV NLR+ +E  +EDLILANPT  E VL + IPG
Sbjct:  153 YFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPG 282
[Close]
BLAST of Beta-arrestin-1 vs. Planmine SMEST
Match: SMESG000078454.1 (SMESG000078454.1)

HSP 1 Score: 134.035 bits (336), Expect = 6.251e-39
Identity = 84/153 (54.90%), Postives = 89/153 (58.17%), Query Frame = 2 
Query:  119 MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVLAKTYSENVGLARIKSSILFSLVTLRFVTNSLYSFINFSLSTSFVFLSESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK 577
            MADFIDSKGGTRVFKKSSLNGKITV      Y+ + D+++  D   P                                                   ESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK
Sbjct:    1 MADFIDSKGGTRVFKKSSLNGKITV------YIGKRDYLERNDHIDP--------------------------------------------------IESFNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILRSSK 97
[Close]
BLAST of Beta-arrestin-1 vs. Planmine SMEST
Match: SMESG000078454.1 (SMESG000078454.1)

HSP 1 Score: 94.7449 bits (234), Expect = 2.435e-21
Identity = 46/51 (90.20%), Postives = 47/51 (92.16%), Query Frame = 2 
Query:  119 MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMVL 271
            MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID    G+VL
Sbjct:    1 MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPID----GVVL 47
The following BLAST results are available for this feature:
BLAST of Beta-arrestin-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ERCC21.145e-2742.36ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC28.161e-2742.36ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC28.441e-2742.36ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC27.275e-2545.16ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC21.282e-2341.61ERCC excision repair 2, TFIIH core complex helicas... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
xpd-14.287e-2139.23XPD (Xeroderma Pigmentosum complementation group D... [more]
arr-15.029e-1063.04Beta-arrestin arr-1 [Source:UniProtKB/Swiss-Prot;... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Xpd4.131e-2439.58gene:FBgn0261850 transcript:FBtr0071576[more]
krz1.634e-859.52gene:FBgn0040206 transcript:FBtr0305268[more]
krz1.634e-859.52gene:FBgn0040206 transcript:FBtr0085877[more]
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BLAST of Beta-arrestin-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc21.461e-2441.10excision repair cross-complementation group 2 [Sou... [more]
arrb2a2.431e-966.67arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131... [more]
arrb2a2.497e-966.67arrestin, beta 2a [Source:ZFIN;Acc:ZDB-GENE-030131... [more]
arrb2b3.563e-966.67arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426... [more]
arrb13.267e-757.14arrestin, beta 1 [Source:ZFIN;Acc:ZDB-GENE-060824-... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ephx32.105e-2543.51epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx32.211e-2543.51epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx32.246e-2543.51epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx31.805e-2243.55epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
arr31.056e-652.50arrestin 3, retinal (X-arrestin) [Source:NCBI gene... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ercc21.696e-2642.36excision repair cross-complementing rodent repair ... [more]
Ercc21.699e-2642.36excision repair cross-complementing rodent repair ... [more]
Ercc22.006e-2341.61excision repair cross-complementing rodent repair ... [more]
Arrb15.662e-863.64arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473][more]
Arrb27.831e-857.78arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474][more]
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BLAST of Beta-arrestin-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P18074|ERCC2_HUMAN3.919e-2642.36General transcription and DNA repair factor IIH he... [more]
sp|Q60452|ERCC2_CRIGR6.036e-2642.36General transcription and DNA repair factor IIH he... [more]
sp|O08811|ERCC2_MOUSE1.186e-2542.36General transcription and DNA repair factor IIH he... [more]
sp|A6QLJ0|ERCC2_BOVIN1.663e-2542.36General transcription and DNA repair factor IIH he... [more]
sp|Q8W4M7|ERCC2_ARATH3.321e-2243.08General transcription and DNA repair factor IIH he... [more]
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BLAST of Beta-arrestin-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0V0J9U02.047e-2744.44Helicase ATP-binding domain-containing protein OS=... [more]
A0A2C9JP282.135e-2748.85Helicase ATP-binding domain-containing protein OS=... [more]
A0A0V0JBE03.012e-2744.44TFIIH basal transcription factor complex helicase ... [more]
A0A0X3NFT23.702e-2744.44Helicase ATP-binding domain-containing protein OS=... [more]
A0A0X3PDU94.266e-2744.44TFIIH basal transcription factor complex helicase ... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc22.440e-2540.97ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc22.597e-2540.97ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc27.406e-2340.88ERCC excision repair 2, TFIIH core complex helicas... [more]
arrb2a1.201e-866.67arrestin red cell [Source:NCBI gene;Acc:103028079][more]
arrb2b3.561e-765.63arrestin, beta 2b [Source:ZFIN;Acc:ZDB-GENE-040426... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ercc25.071e-2542.86excision repair cross-complementation group 2 [Sou... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
RAD37.324e-1733.125' to 3' DNA helicase; involved in nucleotide exci... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO467546.598e-2947.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Beta-arrestin-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc25.934e-2540.28ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc26.222e-2540.28ERCC excision repair 2, TFIIH core complex helicas... [more]
arrb2a3.388e-966.67arrestin beta 2 [Source:NCBI gene;Acc:101159286][more]
arrb2a3.531e-763.64arrestin beta 2 [Source:NCBI gene;Acc:101159286][more]
arrb11.435e-662.50arrestin beta 1 [Source:NCBI gene;Acc:101163309][more]
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BLAST of Beta-arrestin-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000078454.15.401e-10399.35SMESG000078454.1[more]
SMESG000046165.14.565e-4970.00SMESG000046165.1[more]
SMESG000046165.15.278e-4970.00SMESG000046165.1[more]
SMESG000078454.16.251e-3954.90SMESG000078454.1[more]
SMESG000078454.12.435e-2190.20SMESG000078454.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000649 ID=SMED30000649|Name=Beta-arrestin-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1040bp
TGTAGTAACTCAAAAAGAATAAAATTCAATTTATTATCAGATTTCAAGCA
GCTCAGAAAATTTAATGAGACTGGTTTAGAAATTTATTTTAGATTCTAAA
CAATTAAAAAATAAAAACATGGCCGATTTTATAGATAGCAAAGGTGGAAC
TAGAGTGTTTAAGAAATCTTCTCTTAATGGAAAAATAACGGTTTACATTG
GAAAACGAGATTATTTGGAAAGAAATGATCACATCGATCCAATAGATGAT
CGGCTTCCCGGAATGGTTTTAGCTAAAACGTACTCGGAAAATGTTGGGTT
AGCCAGGATCAAATCTTCAATACTCTTTTCACTTGTTACCCTTAGATTTG
TAACCAATTCATTATATTCATTCATTAATTTCTCCTTGTCTACCTCCTTT
GTCTTTCTATCAGAATCCTTCAACGACACTAAACTATTATTCGCTGATTC
GATGGTGTTCCTGTTAATAGTAAAACTCATAGATTCAATGGCAATATTAT
GCGATTCGTCAAAATTTACCACAAACTATTTAGGCAAACCCTTGGTTATG
AGATCAGCAATTTTACGATCGAGTAAATAATAATAGATGTAAACAATTAC
ATTTTCATGTGATATGGTATTTCTGGTTAAAAAATAAAGGTAAAGAAGAG
ATTCGGATATCAAATGAGACTGTATCGCTATCCGGATTGTCTAGCTACTG
AAGGACTTGCAGTTAACCTATGACATGTGGGATCAATGTTGTCACAAAAA
CAAGAATTTAAACACATATTTTTAAAAAATCAACTTTAGCAAGTTTAGAC
CAGACAAAGTACACTTACTGTGGGATATCCTAAATTCCAGCTGGCTCATC
TAAGGCTAAACTAAAAGCTTTACAGTTTTTAACATCAATTTTTAGTGGCA
TGGAATTAACCGTACTTTAAAAAATTCGAAATGATCTTTAAAAAAATATA
ATTTGATGATATAATAATTATTTTTGAGTATTAAAAAAAGATTTTTGTGC
GTTATAAAAATTAAACGAACTTAAACCAATAACATAAGTG
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protein sequence of SMED30000649-orf-1

>SMED30000649-orf-1 ID=SMED30000649-orf-1|Name=SMED30000649-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=154bp
MADFIDSKGGTRVFKKSSLNGKITVYIGKRDYLERNDHIDPIDDRLPGMV
LAKTYSENVGLARIKSSILFSLVTLRFVTNSLYSFINFSLSTSFVFLSES
FNDTKLLFADSMVFLLIVKLIDSMAILCDSSKFTTNYLGKPLVMRSAILR
SSK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR014753Arrestin_N
IPR014756Ig_E-set
IPR010614DEAD_2
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0000187activation of MAPK activity
GO:0001933negative regulation of protein phosphorylation
GO:0001934positive regulation of protein phosphorylation
GO:0002031G-protein coupled receptor internalization
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092positive regulation of receptor internalization
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006366transcription from RNA polymerase II promoter
GO:0006810transport
GO:0006897endocytosis
GO:0006915apoptotic process
GO:0007186G-protein coupled receptor signaling pathway
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007602phototransduction
GO:0008277regulation of G-protein coupled receptor protein signaling pathway
GO:0009968negative regulation of signal transduction
GO:0016567protein ubiquitination
GO:0019233sensory perception of pain
GO:0030817regulation of cAMP biosynthetic process
GO:0030820regulation of cAMP catabolic process
GO:0031397negative regulation of protein ubiquitination
GO:0031398positive regulation of protein ubiquitination
GO:0032088negative regulation of NF-kappaB transcription factor activity
GO:0032092positive regulation of protein binding
GO:0032715negative regulation of interleukin-6 production
GO:0032717negative regulation of interleukin-8 production
GO:0033138positive regulation of peptidyl-serine phosphorylation
GO:0034260negative regulation of GTPase activity
GO:0034393positive regulation of smooth muscle cell apoptotic process
GO:0035025positive regulation of Rho protein signal transduction
GO:0035066positive regulation of histone acetylation
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042493response to drug
GO:0042699follicle-stimulating hormone signaling pathway
GO:0043149stress fiber assembly
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043547positive regulation of GTPase activity
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0050975sensory perception of touch
GO:0070373negative regulation of ERK1 and ERK2 cascade
GO:0070374positive regulation of ERK1 and ERK2 cascade
GO:0090240positive regulation of histone H4 acetylation
GO:0015031protein transport
Vocabulary: molecular function
TermDefinition
GO:0004003ATP-dependent DNA helicase activity
GO:0005524ATP binding
GO:0003677DNA binding
GO:0001664G-protein coupled receptor binding
GO:0005096GTPase activator activity
GO:0005159insulin-like growth factor receptor binding
GO:0005515protein binding
GO:0008134transcription factor binding
GO:0030276clathrin binding
GO:0030331estrogen receptor binding
GO:0031434mitogen-activated protein kinase kinase binding
GO:0031625ubiquitin protein ligase binding
GO:0031691alpha-1A adrenergic receptor binding
GO:0031692alpha-1B adrenergic receptor binding
GO:0031701angiotensin receptor binding
GO:0031762follicle-stimulating hormone receptor binding
GO:0031896V2 vasopressin receptor binding
GO:0035612AP-2 adaptor complex binding
GO:0035615clathrin adaptor activity
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0044212transcription regulatory region DNA binding
GO:0044325ion channel binding
GO:0045309protein phosphorylated amino acid binding
GO:0051219phosphoprotein binding
Vocabulary: cellular component
TermDefinition
GO:0000785chromatin
GO:0005622intracellular
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005886plasma membrane
GO:0005905clathrin-coated pit
GO:0014069postsynaptic density
GO:0016323basolateral plasma membrane
GO:0016604nuclear body
GO:0031143pseudopodium
GO:0031410cytoplasmic vesicle
GO:0042995cell projection
GO:0043197dendritic spine
GO:0045211postsynaptic membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014753Arrestin, N-terminalGENE3DG3DSA:2.60.40.840coord: 5..60
e-value: 9.1E-11
score: 43.6
IPR014756Immunoglobulin E-setSUPERFAMILYSSF81296E set domainscoord: 11..44
NoneNo IPR availableTMHMMTMhelixcoord: 69..91
NoneNo IPR availableTMHMMTMhelixcoord: 106..128