JmjC domain-containing histone demethylation 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30000627 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Match: KDM2B (lysine demethylase 2B [Source:HGNC Symbol;Acc:HGNC:13610]) HSP 1 Score: 352.443 bits (903), Expect = 3.423e-114 Identity = 164/364 (45.05%), Postives = 244/364 (67.03%), Query Frame = 1
Query: 82 PSNLVEYDEN-----IDDVVLTK-WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESN 1149
P + YDEN ++++V + ++L+ KL +++Y G+FV E G DFN + ++ P++F KDGLG+K+P DF+V DV + VG R++DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +V+ P VV +DW+++ WP+ ++ + + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYH+F+G KIFW+ PPT NL+LYE+W LS +QS +F D + C+++ LK G TF IPSGWIH VYTPVDSLVFGGN LHSF++P+QL I+++E++ +V K+RYPF+ EM WYVL +V + S+LT + + +++ + S+
Sbjct: 7 PIDRQRYDENEDLSDVEEIVSVRGFSLEEKLR-SQLYQGDFVHAME-GKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSD 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Match: KDM2B (lysine demethylase 2B [Source:HGNC Symbol;Acc:HGNC:13610]) HSP 1 Score: 353.599 bits (906), Expect = 2.808e-112 Identity = 165/368 (44.84%), Postives = 245/368 (66.58%), Query Frame = 1
Query: 70 AKNAPSNLVEYDEN-----IDDVVLTK-WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESN 1149
A P + YDEN ++++V + ++L+ KL +++Y G+FV E G DFN + ++ P++F KDGLG+K+P DF+V DV + VG R++DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +V+ P VV +DW+++ WP+ ++ + + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYH+F+G KIFW+ PPT NL+LYE+W LS +QS +F D + C+++ LK G TF IPSGWIH VYTPVDSLVFGGN LHSF++P+QL I+++E++ +V K+RYPF+ EM WYVL +V + S+LT + + +++ + S+
Sbjct: 40 ATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLR-SQLYQGDFVHAME-GKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSD 405
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Match: KDM2A (lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606]) HSP 1 Score: 354.755 bits (909), Expect = 8.153e-112 Identity = 166/343 (48.40%), Postives = 237/343 (69.10%), Query Frame = 1
Query: 115 DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
DD + K ++L+ KL N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 29 DDEIEGKRTFDLEEKLHTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEF-QKESLSMDLELNGL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Match: KDM2A (lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606]) HSP 1 Score: 354.755 bits (909), Expect = 1.050e-108 Identity = 163/334 (48.80%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 21 FDLEEKLHTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEF-QKESLSMDLELNGL 351
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Match: KDM2A (lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606]) HSP 1 Score: 354.755 bits (909), Expect = 1.141e-108 Identity = 163/334 (48.80%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLHTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEF-QKESLSMDLELNGL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Match: jhdm-1 (JmjC domain-containing histone demethylation protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q95Q98]) HSP 1 Score: 268.855 bits (686), Expect = 8.403e-82 Identity = 131/295 (44.41%), Postives = 194/295 (65.76%), Query Frame = 1
Query: 214 FNLKTLELNGFSKPILF-VNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQ--LLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHV-----DNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL 1074
NL+ + NG PI F + +G+ LP DFSVDDV VG +R+++VV V+ Q ++ M+++++ +YK P + + L NV+SLE+SQ+ L+ +V++P++V Q+DW+ + WP+ R + D K Y T+PKV+ YCLMSVA CYTDFHID GTSVWYH+ KG K+FW+ PPT N +Y+++ + + + FF + +C L+PG+T +IPSGWIH VYTP DSLVFGGNFLHS S QL ++ VE K+ + K+R P+ E+ +YV+A +V + G Y+
Sbjct: 79 LNLEFYDKNGLDNPIHFRCDPKRIGMTLPSPDFSVDDVLELVGGNRMIEVVQVQNQGSVKMSLQEFINFYKTPQEKREVLYNVLSLEFSQTPLEDLVKSPELVRQIDWVGNQWPDALRQRWISFNGRDKKFYNPHHTFPKVQNYCLMSVANCYTDFHIDFSGTSVWYHVLKGRKVFWLIPPTETNFFIYQEF-IKTVNDNAFFGKSVEKCHVAILEPGDTMLIPSGWIHAVYTPDDSLVFGGNFLHSQSCKTQLRVYQVENKLNITRKFRLPYNEELIFYVIADYVKQWTGREYV 372
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Match: jhdm-1 (JmjC domain-containing histone demethylation protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q95Q98]) HSP 1 Score: 271.552 bits (693), Expect = 9.344e-79 Identity = 131/295 (44.41%), Postives = 194/295 (65.76%), Query Frame = 1
Query: 214 FNLKTLELNGFSKPILF-VNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQ--LLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHV-----DNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL 1074
NL+ + NG PI F + +G+ LP DFSVDDV VG +R+++VV V+ Q ++ M+++++ +YK P + + L NV+SLE+SQ+ L+ +V++P++V Q+DW+ + WP+ R + D K Y T+PKV+ YCLMSVA CYTDFHID GTSVWYH+ KG K+FW+ PPT N +Y+++ + + + FF + +C L+PG+T +IPSGWIH VYTP DSLVFGGNFLHS S QL ++ VE K+ + K+R P+ E+ +YV+A +V + G Y+
Sbjct: 79 LNLEFYDKNGLDNPIHFRCDPKRIGMTLPSPDFSVDDVLELVGGNRMIEVVQVQNQGSVKMSLQEFINFYKTPQEKREVLYNVLSLEFSQTPLEDLVKSPELVRQIDWVGNQWPDALRQRWISFNGRDKKFYNPHHTFPKVQNYCLMSVANCYTDFHIDFSGTSVWYHVLKGRKVFWLIPPTETNFFIYQEF-IKTVNDNAFFGKSVEKCHVAILEPGDTMLIPSGWIHAVYTPDDSLVFGGNFLHSQSCKTQLRVYQVENKLNITRKFRLPYNEELIFYVIADYVKQWTGREYV 372
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Match: jmjd-1.2 (Lysine-specific demethylase 7 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9GYI0]) HSP 1 Score: 190.66 bits (483), Expect = 3.626e-51 Identity = 103/313 (32.91%), Postives = 176/313 (56.23%), Query Frame = 1
Query: 199 ENGWDFNLKTLELNG---FSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKN-PNKTQLLNVISLEYS-QSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHV---DNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVE----EKIKVGTKYRYPFFIEMHW-YVLAAFVGRINGISYLTSSLNQNK 1098
E+G++F + +L G + K + + DGL + +P F ++DV +G +D +DV Q+ M + + + +++ N+ L N +SLE+S +++ I + P V ++ + WP+ ++ + YL PKV ++CL +AG YTDFH+D GG+SV+YHI KGEKIF+IA PT N + Y+ S + ++ F ++V +K G T +IP+GWIH V TPVDSLVFGGNFLH ++ +Q+ ++ +E ++I+ K+ +P F +HW Y+ + +I + S + + +
Sbjct: 366 EDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQE 678
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Match: jmjd-1.2 (Lysine-specific demethylase 7 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9GYI0]) HSP 1 Score: 190.274 bits (482), Expect = 4.255e-51 Identity = 103/313 (32.91%), Postives = 176/313 (56.23%), Query Frame = 1
Query: 199 ENGWDFNLKTLELNG---FSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKN-PNKTQLLNVISLEYSQS-KLDAIVRAPDVVLQLDWLESCWPEKCRDIHV---DNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVE----EKIKVGTKYRYPFFIEMHW-YVLAAFVGRINGISYLTSSLNQNK 1098
E+G++F + +L G + K + + DGL + +P F ++DV +G +D +DV Q+ M + + + +++ N+ L N +SLE+S + ++ I + P V ++ + WP+ ++ + YL PKV ++CL +AG YTDFH+D GG+SV+YHI KGEKIF+IA PT N + Y+ S + ++ F ++V +K G T +IP+GWIH V TPVDSLVFGGNFLH ++ +Q+ ++ +E ++I+ K+ +P F +HW Y+ + +I + S + + +
Sbjct: 347 EDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQE 659
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Match: jmjd-1.2 (Lysine-specific demethylase 7 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9GYI0]) HSP 1 Score: 190.274 bits (482), Expect = 4.346e-51 Identity = 103/313 (32.91%), Postives = 176/313 (56.23%), Query Frame = 1
Query: 199 ENGWDFNLKTLELNG---FSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKN-PNKTQLLNVISLEYS-QSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHV---DNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVE----EKIKVGTKYRYPFFIEMHW-YVLAAFVGRINGISYLTSSLNQNK 1098
E+G++F + +L G + K + + DGL + +P F ++DV +G +D +DV Q+ M + + + +++ N+ L N +SLE+S +++ I + P V ++ + WP+ ++ + YL PKV ++CL +AG YTDFH+D GG+SV+YHI KGEKIF+IA PT N + Y+ S + ++ F ++V +K G T +IP+GWIH V TPVDSLVFGGNFLH ++ +Q+ ++ +E ++I+ K+ +P F +HW Y+ + +I + S + + +
Sbjct: 334 EDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQE 646
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Fly
Match: Kdm2 (gene:FBgn0037659 transcript:FBtr0336759) HSP 1 Score: 379.407 bits (973), Expect = 5.445e-117 Identity = 184/384 (47.92%), Postives = 260/384 (67.71%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP-PDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL--TSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACK 1266
+++ KLE ++ V R G D + L+ +GF+ P+LF +K GLGL++P P +F+V+DV + VG R+LDV+DV TQ + MTMK+W +YY +P K +LLNVISLE+S ++LD V++P++V Q+DW++ WP++ +D + + L + YPKV+KYCLMSV CYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +Q+ +FF D + +C +V+L GNTF IP+GWIH VYTP SLVFGGNFLHSF I QL VE+ KV K+RYPFF EM WYVLA +V + G S+L +SL++++ ++ ++ L +E G++ I +L ++ K+VP+ + DP AL+ D ER CK
Sbjct: 70 FSVAEKLESSKFAQAGMV-REMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHT--HLTHHELFGLKEIVMYLYDLPPQK-KNVPSLVLDPVALIKDVRSLVERHCK 449
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Fly
Match: Kdm2 (gene:FBgn0037659 transcript:FBtr0300691) HSP 1 Score: 379.407 bits (973), Expect = 5.445e-117 Identity = 184/384 (47.92%), Postives = 260/384 (67.71%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP-PDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL--TSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACK 1266
+++ KLE ++ V R G D + L+ +GF+ P+LF +K GLGL++P P +F+V+DV + VG R+LDV+DV TQ + MTMK+W +YY +P K +LLNVISLE+S ++LD V++P++V Q+DW++ WP++ +D + + L + YPKV+KYCLMSV CYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +Q+ +FF D + +C +V+L GNTF IP+GWIH VYTP SLVFGGNFLHSF I QL VE+ KV K+RYPFF EM WYVLA +V + G S+L +SL++++ ++ ++ L +E G++ I +L ++ K+VP+ + DP AL+ D ER CK
Sbjct: 70 FSVAEKLESSKFAQAGMV-REMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHT--HLTHHELFGLKEIVMYLYDLPPQK-KNVPSLVLDPVALIKDVRSLVERHCK 449
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Fly
Match: Kdm2 (gene:FBgn0037659 transcript:FBtr0336760) HSP 1 Score: 379.407 bits (973), Expect = 5.445e-117 Identity = 184/384 (47.92%), Postives = 260/384 (67.71%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP-PDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL--TSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACK 1266
+++ KLE ++ V R G D + L+ +GF+ P+LF +K GLGL++P P +F+V+DV + VG R+LDV+DV TQ + MTMK+W +YY +P K +LLNVISLE+S ++LD V++P++V Q+DW++ WP++ +D + + L + YPKV+KYCLMSV CYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +Q+ +FF D + +C +V+L GNTF IP+GWIH VYTP SLVFGGNFLHSF I QL VE+ KV K+RYPFF EM WYVLA +V + G S+L +SL++++ ++ ++ L +E G++ I +L ++ K+VP+ + DP AL+ D ER CK
Sbjct: 70 FSVAEKLESSKFAQAGMV-REMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHT--HLTHHELFGLKEIVMYLYDLPPQK-KNVPSLVLDPVALIKDVRSLVERHCK 449
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Fly
Match: Kdm2 (gene:FBgn0037659 transcript:FBtr0336758) HSP 1 Score: 379.407 bits (973), Expect = 5.445e-117 Identity = 184/384 (47.92%), Postives = 260/384 (67.71%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP-PDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL--TSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACK 1266
+++ KLE ++ V R G D + L+ +GF+ P+LF +K GLGL++P P +F+V+DV + VG R+LDV+DV TQ + MTMK+W +YY +P K +LLNVISLE+S ++LD V++P++V Q+DW++ WP++ +D + + L + YPKV+KYCLMSV CYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +Q+ +FF D + +C +V+L GNTF IP+GWIH VYTP SLVFGGNFLHSF I QL VE+ KV K+RYPFF EM WYVLA +V + G S+L +SL++++ ++ ++ L +E G++ I +L ++ K+VP+ + DP AL+ D ER CK
Sbjct: 70 FSVAEKLESSKFAQAGMV-REMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHT--HLTHHELFGLKEIVMYLYDLPPQK-KNVPSLVLDPVALIKDVRSLVERHCK 449
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Match: kdm2ab (lysine (K)-specific demethylase 2Ab [Source:ZFIN;Acc:ZDB-GENE-101007-5]) HSP 1 Score: 351.673 bits (901), Expect = 3.578e-107 Identity = 162/331 (48.94%), Postives = 230/331 (69.49%), Query Frame = 1
Query: 115 DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
DD + K ++L+ KL+ +R Y+ N V + +G DF L+ ++ G PI+F DGLG+K+P DFSV DV + VG R++DV+D TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYHI KG K+FW+ PPTP NL LYE W LS++Q +F D + C+++ LK G TFMIPSGWIH VYTP+D+LVFGGNFLHSF+IP+QL I+++E++ +V +K+RYPF+ EM WYVL ++ + S+LT ++
Sbjct: 27 DDEIEGKRSFDLEEKLQSDR-YNSNLV-KIMDGKDFTLEYIQREGLRDPIIFKKADGLGIKMPDPDFSVSDVKLFVGSRRMIDVMDAATQKGIEMSMGQWRRYYETPASQREKLYNVISLEFSHTKLEHLVKRPTSVDMIDWVDNMWPRHLKERQRDSTNAITDMQYPKVQKYCLMSVEGCFTDFHIDFGGTSVWYHIHKGGKVFWLIPPTPQNLELYENWVLSAKQGDIFLGDKASMCQRIELKQGYTFMIPSGWIHAVYTPMDTLVFGGNFLHSFNIPMQLNIFNIEDRTRVPSKFRYPFYFEMCWYVLERYLYCLTNTSHLTPEFQKH 355
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Match: kdm2ab (lysine (K)-specific demethylase 2Ab [Source:ZFIN;Acc:ZDB-GENE-101007-5]) HSP 1 Score: 351.673 bits (901), Expect = 5.538e-107 Identity = 162/331 (48.94%), Postives = 230/331 (69.49%), Query Frame = 1
Query: 115 DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
DD + K ++L+ KL+ +R Y+ N V + +G DF L+ ++ G PI+F DGLG+K+P DFSV DV + VG R++DV+D TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYHI KG K+FW+ PPTP NL LYE W LS++Q +F D + C+++ LK G TFMIPSGWIH VYTP+D+LVFGGNFLHSF+IP+QL I+++E++ +V +K+RYPF+ EM WYVL ++ + S+LT ++
Sbjct: 35 DDEIEGKRSFDLEEKLQSDR-YNSNLV-KIMDGKDFTLEYIQREGLRDPIIFKKADGLGIKMPDPDFSVSDVKLFVGSRRMIDVMDAATQKGIEMSMGQWRRYYETPASQREKLYNVISLEFSHTKLEHLVKRPTSVDMIDWVDNMWPRHLKERQRDSTNAITDMQYPKVQKYCLMSVEGCFTDFHIDFGGTSVWYHIHKGGKVFWLIPPTPQNLELYENWVLSAKQGDIFLGDKASMCQRIELKQGYTFMIPSGWIHAVYTPMDTLVFGGNFLHSFNIPMQLNIFNIEDRTRVPSKFRYPFYFEMCWYVLERYLYCLTNTSHLTPEFQKH 363
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Match: kdm2aa (lysine (K)-specific demethylase 2Aa [Source:ZFIN;Acc:ZDB-GENE-061215-144]) HSP 1 Score: 343.969 bits (881), Expect = 2.017e-104 Identity = 160/333 (48.05%), Postives = 226/333 (67.87%), Query Frame = 1
Query: 103 DENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
D+ ID ++L+ KL + +S + V+R E G DF+ + ++ +G PI+F +GLG+K+P DF+V+DV + VG RI+DV+DV TQ M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI KG K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TF+IPSGWIH VYTPVD+LVFGGNFLHSF++P+QL I +E++ +V K+RYPFF EM WYVL ++ + S+L ++
Sbjct: 29 DDEIDG--RRTFDLEEKLHSS-FFSSDRVKRME-GKDFSYEYVQRHGLRDPIIFEKPEGLGIKMPDPDFTVNDVKLFVGSRRIVDVMDVATQKGTEMSMAQWRRYYETPPSQREKLYNVISLEFSHTKLETLVKRPSTVDMIDWVDNMWPRHLKERQRDSTNSIMEMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHIHKGCKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDRATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNVPMQLDISGIEDRTRVPVKFRYPFFFEMCWYVLERYLYSLTNKSHLIPEFQKH 357
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Match: kdm2aa (lysine (K)-specific demethylase 2Aa [Source:ZFIN;Acc:ZDB-GENE-061215-144]) HSP 1 Score: 344.354 bits (882), Expect = 2.595e-104 Identity = 160/333 (48.05%), Postives = 226/333 (67.87%), Query Frame = 1
Query: 103 DENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
D+ ID ++L+ KL + +S + V+R E G DF+ + ++ +G PI+F +GLG+K+P DF+V+DV + VG RI+DV+DV TQ M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI KG K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TF+IPSGWIH VYTPVD+LVFGGNFLHSF++P+QL I +E++ +V K+RYPFF EM WYVL ++ + S+L ++
Sbjct: 29 DDEIDG--RRTFDLEEKLHSS-FFSSDRVKRME-GKDFSYEYVQRHGLRDPIIFEKPEGLGIKMPDPDFTVNDVKLFVGSRRIVDVMDVATQKGTEMSMAQWRRYYETPPSQREKLYNVISLEFSHTKLETLVKRPSTVDMIDWVDNMWPRHLKERQRDSTNSIMEMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHIHKGCKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDRATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNVPMQLDISGIEDRTRVPVKFRYPFFFEMCWYVLERYLYSLTNKSHLIPEFQKH 357
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Match: CU928082.1 (lysine-specific demethylase 2B [Source:NCBI gene;Acc:100536129]) HSP 1 Score: 323.168 bits (827), Expect = 4.476e-103 Identity = 168/393 (42.75%), Postives = 242/393 (61.58%), Query Frame = 1
Query: 100 YDENID--DVV----LTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKW----LKEISLDTFKSVPNDIADPAALL 1242
YDEN D DV + ++L+ KL+ + Y+ V+ E G DF + ++ P++F KDGLG+++P +F+V ++ VG R +DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +++ P V L +DW+++ WP + + + + + YPKV++YCLMSV GC+TDFHID GGTSVWYH+FKG+K+FW+ PP NLSLYE W LS +QS +F D C++V LK G TF IPSGWIH VYTP D+LVFGGN LHSF+IP+QL ++++E + KV +K+RYPFF EM WYVL +V + S+L SL + +I L + G+ + + E + TFK ND D + L
Sbjct: 28 YDENEDLSDVEEITNVRGFSLEDKLD-SASYNSQLVQFME-GKDFTYEYVQREALRTPLVFKAKDGLGIRMPDPEFTVSEIKGLVGSRRPVDVMDVSTQKGSEMSMAQFVRYYETPEDERDKLFNVISLEFSHTKLENLIKRPTVDL-VDWVDNMWPRHLKQKQTEATNVMSEMKYPKVQRYCLMSVKGCFTDFHIDFGGTSVWYHVFKGQKVFWLIPPNAHNLSLYEDWVLSGKQSDIFLGDRADGCQRVELKQGYTFFIPSGWIHAVYTPEDTLVFGGNILHSFNIPMQLTVYEIENRTKVHSKFRYPFFYEMCWYVLERYVSCLTKRSHL--SLEFRNHTGESAAIRNL----AFGVLRYATFELLLMTESLMSTFKPSANDSEDSSKSL 411
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Match: kdm2a (lysine (K)-specific demethylase 2A [Source:NCBI gene;Acc:496596]) HSP 1 Score: 370.163 bits (949), Expect = 2.778e-116 Identity = 185/403 (45.91%), Postives = 259/403 (64.27%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLT------------------------SSLNQNKSISKVNSINT--LNQYESNGIRSICKWLKEISLDTF-KSVPNDIADPAALLSDAER 1257
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT S L + K IS + I + L +E G+R C LK SL K +P+ I DP AL+ D +R
Sbjct: 35 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEFQRESLSIGKCLSSILSHGEGASGLEEEKEISVIRGITSPFLTWFEVEGLR--CLVLKLESLPPLKKCLPDGIHDPEALIFDIKR 433
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Match: kdm2a (lysine (K)-specific demethylase 2A [Source:NCBI gene;Acc:496596]) HSP 1 Score: 370.163 bits (949), Expect = 2.854e-116 Identity = 185/403 (45.91%), Postives = 259/403 (64.27%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLT------------------------SSLNQNKSISKVNSINT--LNQYESNGIRSICKWLKEISLDTF-KSVPNDIADPAALLSDAER 1257
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT S L + K IS + I + L +E G+R C LK SL K +P+ I DP AL+ D +R
Sbjct: 22 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEFQRESLSIGKCLSSILSHGEGASGLEEEKEISVIRGITSPFLTWFEVEGLR--CLVLKLESLPPLKKCLPDGIHDPEALIFDIKR 420
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Match: kdm2a (lysine (K)-specific demethylase 2A [Source:NCBI gene;Acc:496596]) HSP 1 Score: 357.836 bits (917), Expect = 9.058e-115 Identity = 196/478 (41.00%), Postives = 280/478 (58.58%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLT-----SSLNQNKSISKVNS----------------------INTLNQ----------------------------YESNGIRSICKWLKEISLDTFKS-VPNDIADPAALLSDAERACKSIILDSNSFNHAESFITSAKSEQ--KTGQINNNIDLGLLSSNS 1389
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT SL+ K +S + S I+TL +E G+R C LK SL K +P+ I DP AL+ D +R +L+ ++ + E +T Q K Q+N N+ L S +
Sbjct: 36 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEFQRESLSIGKCLSSILSHALDRQQRDQERDRHGRTERIIIHTLPASLRPLTPPPSLPLPTPDSPPSTSPFLTWFEVEGLR--CLVLKLESLPPLKKCLPDGIHDPEALIFDIKR-----LLEDHAHDPPELALTGVPIIQWPKRSQVNFNLYLCTPSGTT 504
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Match: kdm2a (lysine (K)-specific demethylase 2A [Source:NCBI gene;Acc:496596]) HSP 1 Score: 362.459 bits (929), Expect = 3.471e-112 Identity = 185/411 (45.01%), Postives = 258/411 (62.77%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNK-SISKVNS-----INTLNQ----------------------------YESNGIRSICKWLKEISLDTF-KSVPNDIADPAALLSDAER 1257
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT + SI K S I+TL +E G+R C LK SL K +P+ I DP AL+ D +R
Sbjct: 40 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEFQRESLSIGKCLSSILIIIHTLPASLRPLTPPPSLPLPTPDSPPSTSPFLTWFEVEGLR--CLVLKLESLPPLKKCLPDGIHDPEALIFDIKR 446
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Match: kdm2a (lysine (K)-specific demethylase 2A [Source:NCBI gene;Acc:496596]) HSP 1 Score: 357.836 bits (917), Expect = 4.324e-111 Identity = 164/326 (50.31%), Postives = 231/326 (70.86%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSIS 1107
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT Q +S+S
Sbjct: 50 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEF-QRESLS 372
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Match: Kdm2a (lysine (K)-specific demethylase 2A [Source:MGI Symbol;Acc:MGI:1354736]) HSP 1 Score: 356.295 bits (913), Expect = 5.061e-116 Identity = 164/334 (49.10%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL+ N+ Y+ NFV E G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLQTNK-YNANFVTFME-GKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDF-QKESLSMDMELNEL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Match: Kdm2b (lysine (K)-specific demethylase 2B [Source:MGI Symbol;Acc:MGI:1354737]) HSP 1 Score: 353.599 bits (906), Expect = 1.054e-114 Identity = 164/340 (48.24%), Postives = 236/340 (69.41%), Query Frame = 1
Query: 100 YDEN-----IDDVVLTK-WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
YDEN ++++V + ++L+ KL +++Y G+FV E G DFN + ++ P++F +KDGLG+K+P DF+V DV + VG R++DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +V+ P VV +DW+++ WP+ ++ + + L + YPKV+KYCLMSV GC+TDFHID GGTSVWYH+F+G KIFW+ PPT NL+LYE+W LS +QS +F D + C+++ LK G TF IPSGWIH VYTPVDSLVFGGN LHSF++P+QL I+++E++ +V K+RYPF+ EM WYVL +V + SYLT +
Sbjct: 13 YDENEDLSDVEEIVSVRGFSLEEKLR-SQLYQGDFVHAME-GKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQRE 350
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Match: Kdm2a (lysine (K)-specific demethylase 2A [Source:MGI Symbol;Acc:MGI:1354736]) HSP 1 Score: 355.525 bits (911), Expect = 3.914e-109 Identity = 163/334 (48.80%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL+ N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLQTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDF-QKESLSMDMELNEL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Match: Kdm2a (lysine (K)-specific demethylase 2A [Source:MGI Symbol;Acc:MGI:1354736]) HSP 1 Score: 355.525 bits (911), Expect = 3.914e-109 Identity = 163/334 (48.80%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL+ N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLQTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDF-QKESLSMDMELNEL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Match: Kdm2b (lysine (K)-specific demethylase 2B [Source:MGI Symbol;Acc:MGI:1354737]) HSP 1 Score: 352.829 bits (904), Expect = 1.893e-107 Identity = 164/339 (48.38%), Postives = 236/339 (69.62%), Query Frame = 1
Query: 100 YDEN-----IDDVVLTK-WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQ 1092
YDEN ++++V + ++L+ KL +++Y G+FV E G DFN + ++ P++F +KDGLG+K+P DF+V DV + VG R++DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +V+ P VV +DW+++ WP+ ++ + + L + YPKV+KYCLMSV GC+TDFHID GGTSVWYH+F+G KIFW+ PPT NL+LYE+W LS +QS +F D + C+++ LK G TF IPSGWIH VYTPVDSLVFGGN LHSF++P+QL I+++E++ +V K+RYPF+ EM WYVL +V + SYLT +
Sbjct: 19 YDENEDLSDVEEIVSVRGFSLEEKLR-SQLYQGDFVHAME-GKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQR 355
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Match: sp|Q9VHH9|JHD1_DROME (JmjC domain-containing histone demethylation protein 1 OS=Drosophila melanogaster OX=7227 GN=Kdm2 PE=1 SV=2) HSP 1 Score: 379.407 bits (973), Expect = 5.458e-116 Identity = 184/384 (47.92%), Postives = 260/384 (67.71%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP-PDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL--TSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACK 1266
+++ KLE ++ V R G D + L+ +GF+ P+LF +K GLGL++P P +F+V+DV + VG R+LDV+DV TQ + MTMK+W +YY +P K +LLNVISLE+S ++LD V++P++V Q+DW++ WP++ +D + + L + YPKV+KYCLMSV CYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +Q+ +FF D + +C +V+L GNTF IP+GWIH VYTP SLVFGGNFLHSF I QL VE+ KV K+RYPFF EM WYVLA +V + G S+L +SL++++ ++ ++ L +E G++ I +L ++ K+VP+ + DP AL+ D ER CK
Sbjct: 70 FSVAEKLESSKFAQAGMV-REMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHT--HLTHHELFGLKEIVMYLYDLPPQK-KNVPSLVLDPVALIKDVRSLVERHCK 449
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Match: sp|Q5U263|KDM2A_XENTR (Lysine-specific demethylase 2A OS=Xenopus tropicalis OX=8364 GN=kdm2a PE=2 SV=1) HSP 1 Score: 358.992 bits (920), Expect = 1.084e-109 Identity = 164/326 (50.31%), Postives = 231/326 (70.86%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSIS 1107
++L+ KL ++ Y+ NF+ Y G DFN+K ++ G PI+F +GLG+K+P +FSV+DV + VG R++DV+DV TQ I MTM W +YY+ P + +L NVISLE+S +KL+ +V+ P V Q+DW+++ WP +D ++ + ++ + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D + EC+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V TK+RYPF+ EM WYVL +V + S+LT Q +S+S
Sbjct: 36 FDLEEKLRSSK-YNSNFIT-YMEGKDFNMKFIQEGGLRDPIIFTKSEGLGIKMPDPNFSVNDVKMFVGSRRVVDVMDVGTQKGIEMTMAQWAKYYETPEEEREKLYNVISLEFSHTKLENLVQRPTTVDQIDWVDNIWPRHLKDRQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHILRGGKVFWLIPPTDQNLELYENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVIPSGWIHAVYTPQDTLVFGGNFLHSFNIPMQLRIYSIEDRTRVPTKFRYPFYYEMCWYVLERYVYCMMRRSHLTKEF-QRESLS 358
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Match: sp|Q9Y2K7|KDM2A_HUMAN (Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3) HSP 1 Score: 354.755 bits (909), Expect = 5.481e-108 Identity = 163/334 (48.80%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLHTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEF-QKESLSMDLELNGL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Match: sp|P59997|KDM2A_MOUSE (Lysine-specific demethylase 2A OS=Mus musculus OX=10090 GN=Kdm2a PE=1 SV=2) HSP 1 Score: 352.443 bits (903), Expect = 4.490e-107 Identity = 162/334 (48.50%), Postives = 233/334 (69.76%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTL 1131
++L+ KL+ N+ Y+ NFV + G DFN++ ++ G P++F N DGLG+K+P DF+V+DV + VG R++DV+DV TQ I MTM W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ ++ + + + YPKV+KYCL+SV GCYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D +++C+++ LK G TF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+ +E++ +V K+RYPF+ EM WYVL +V I S+LT Q +S+S +N L
Sbjct: 38 FDLEEKLQTNK-YNANFVT-FMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQWPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLISVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDF-QKESLSMDMELNEL 368
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Match: sp|Q640I9|KDM2B_XENLA (Lysine-specific demethylase 2B OS=Xenopus laevis OX=8355 GN=kdm2b PE=2 SV=1) HSP 1 Score: 353.214 bits (905), Expect = 7.215e-107 Identity = 159/336 (47.32%), Postives = 230/336 (68.45%), Query Frame = 1
Query: 109 NIDDVV-LTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSIS 1107
+++D+V + ++L+ K+ N Y GNFV RY G DF + ++ P+LF K+GLG+K+P DF+V DV + VG R++DV+DV TQ +I M+M + YY+ P + +L NVISLE+S +KL+ +V+ P VV +DW+++ WP ++ ++ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYH+F+G K+FW+ PPT NL LYE+W LS +Q+ +F D C+++ LK G TF IPSGWIH VYTP DSLVFGGN LHSF+IP+QL ++++E++ +V K+RYPF+ EM WYVL +V + S+L + I+
Sbjct: 27 DVEDMVSIRGFSLEQKVSCN-AYRGNFV-RYMEGKDFTYEYVQREALQTPLLFSTKEGLGIKMPEQDFTVRDVKLLVGSRRVVDVMDVNTQKSIDMSMSQFVRYYETPEMEREKLYNVISLEFSHTKLERVVKRPTVVDAVDWVDNMWPRHLKEQQKESTNVIAEMKYPKVKKYCLMSVKGCYTDFHIDFGGTSVWYHVFRGGKVFWLIPPTGHNLQLYEEWLLSGKQTDIFLGDRSEGCQRIELKQGQTFFIPSGWIHAVYTPADSLVFGGNILHSFNIPMQLRVFEIEDRTRVNAKFRYPFYYEMCWYVLERYVCTLTKRSHLIKEYQRESMIT 360
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Match: A0A3M7Q966 (Domain-containing histone demethylation 1 OS=Brachionus plicatilis OX=10195 GN=BpHYR1_011951 PE=4 SV=1) HSP 1 Score: 405.601 bits (1041), Expect = 2.204e-131 Identity = 193/383 (50.39%), Postives = 265/383 (69.19%), Query Frame = 1
Query: 133 KWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINT--------LNQYESNGIRSICKWLKEISLDTFKS-VPNDIADPAALLSDAE 1254
KWNL KL Y NFV +Y +FN K ++ NG PI+F++K GLG+++P ++F V DV VG RI+DVVDV TQ A+ M+MK+WCEYY+NP++ +LLNVISLE+S +KL+ V AP VV QLDW+++ WP+ R+ H ++ + ++ + YPKV+KY LMSVAGCYTDFH+D+GGTSVWYH+ KGEKIFW+ PPT NL +YEKW LS QS +F PDL+ +C++V LK G+TF++PSGWIHGVYT DSLVFGGNFLHSF++ +QL I+ +E K KV K+RYPF+ EM W+VL +V ++GI+++ N T LN+YE NG++++ ++L I L+ K VP +I P LL +
Sbjct: 127 KWNLDEKLNIVSKYDSNFV-KYLEAKEFNFKYVQENGLETPIVFLDKSGLGMRVPSENFRVSDVKSCVGSKRIVDVVDVNTQKALTMSMKEWCEYYENPSRDRLLNVISLEFSHTKLENYVEAPLVVRQLDWIDTAWPQHLRESHTESTNLIEKMKYPKVQKYVLMSVAGCYTDFHVDMGGTSVWYHLLKGEKIFWLIPPTEKNLKIYEKWILSGNQSRVFLPDLMDKCQRVVLKQGSTFILPSGWIHGVYTSKDSLVFGGNFLHSFNVRMQLKIYSIETKTKVPQKFRYPFYTEMMWFVLERYVHCLSGITHIDDFSESNGEFDPKQPFKTFQPEPNQVLNKYELNGLKALYEFL--IGLNENKRCVPKEIVQPKILLGSVK 506
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Match: A0A1E1WN12 (JmjC domain-containing protein (Fragment) OS=Pectinophora gossypiella OX=13191 GN=g.17063 PE=4 SV=1) HSP 1 Score: 384.03 bits (985), Expect = 1.993e-124 Identity = 187/374 (50.00%), Postives = 252/374 (67.38%), Query Frame = 1
Query: 136 WNLQSKLE-PNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAE 1254
++L KLE P +SG+ E + G + + L+ +GF+ P+LF +K GLGL++P +F+V+DV + VG R+LDV+DV TQ I MTMKDW YY +PNK +LLNVISLE+S ++L+ V+AP +V Q+DW+++ WP +D ++ + L + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +QS +FF D + +C +VHL+ G+TF IP+GWIH VYTP DSLVFGGNFLH F I QL I VE+ KV K+RYPFF EM WYVL +V + G S+L I+ L Q E +G+++I +L ++ KSVP ++DP AL+ D
Sbjct: 42 FSLADKLESPRFEHSGSVHEMH--GSELTVSYLQKHGFTTPLLFKDKLGLGLRVPTSNFTVNDVRMCVGSRRLLDVMDVNTQKNIEMTMKDWQRYYDDPNKERLLNVISLEFSHTRLENYVQAPRIVRQIDWVDTVWPRHLKDQQTESTNALDDMMYPKVQKYCLMSVKGCYTDFHIDFGGTSVWYHILRGAKVFWLIPPTEKNLQLYEKWVLSGKQSDVFFGDTVEKCIRVHLQAGHTFFIPTGWIHAVYTPSDSLVFGGNFLHQFGIEKQLKIAQVEDVTKVPQKFRYPFFTEMLWYVLDRYVSSLLGRSHLAPEGQSTPPTPPKEHIH-LTQNELHGLKAIVMYLHQLPA-ARKSVPELLSDPIALVRDVR 411
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Match: A0A4Y6ESB8 (JmjC domain-containing histone demethylation 1 OS=Brachionus koreanus OX=1199090 PE=2 SV=1) HSP 1 Score: 400.979 bits (1029), Expect = 3.087e-124 Identity = 188/383 (49.09%), Postives = 266/383 (69.45%), Query Frame = 1
Query: 133 KWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYL------TSSLNQNKSIS--KVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAER 1257
KWNL KL Y+ NFV +Y +FN K ++ NG P++F++K GLG+++P ++F V DV VG RI+DVVDV TQ A+ M+MK+WCEYY+NPN+ +LLNVISLE+S +KL+ V AP VV QLDW+E+ WP R+ H ++ + ++ + YPKV+KY LMSVAGCYTDFH+D+GGTSVWYH+ KGEKIFW+ PP+ NL +YEKW LS QS +F PDL+ EC+++ LK G+TF++PSGWIHGVYT DSLVFGGNFLHSF++ +QL I +E K KV K+RYPF+ EM W+VL +V + G +++ S+L + + S LN++E +G++++ +L ++ + + VP +I P LL ++
Sbjct: 126 KWNLDEKLNIVSKYNSNFV-KYLEAKEFNFKYVQENGLESPLVFMDKSGLGMRVPSENFRVSDVKSCVGSKRIVDVVDVNTQKALTMSMKEWCEYYENPNRDRLLNVISLEFSHTKLENYVEAPLVVRQLDWIETAWPRHLRESHTESTNLIEKMKYPKVQKYVLMSVAGCYTDFHVDMGGTSVWYHLLKGEKIFWLIPPSKKNLKIYEKWILSGNQSKVFLPDLMDECQRIVLKQGSTFILPSGWIHGVYTSKDSLVFGGNFLHSFNVCMQLKIHSIETKTKVPQKFRYPFYNEMIWFVLERYVHCLTGTTHIDDFTECKSALEDKQPFKTFQPESNQVLNKFELDGLKALFDFLTGLN-ENKRCVPKEIVQPKILLESVQK 506
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Match: A0A182SVD2 (JmjC domain-containing protein OS=Anopheles maculatus OX=74869 PE=4 SV=1) HSP 1 Score: 380.178 bits (975), Expect = 2.674e-122 Identity = 185/383 (48.30%), Postives = 254/383 (66.32%), Query Frame = 1
Query: 136 WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSD----AERACKSI 1272
+++ KLE R V R G + + L+ NGF+ P+LF K GLGL++P +FS+ DV + VG R+LDV+DV TQ + MTMK+W +YY++P+K +LLNVISLE+S +KL+ V++P +V Q+DW++ WP++ ++ V++ + L + YPKV+KYCLMSV CYTDFH+D GGTSVWYHI +G K+FW+ PPT NL LYEKW LS +QS +FF D + +C +V+L GNTF IP+GWIH VYTP DSLVFGGNFLHSF I QL I VE+ KV K+RYPFF EM WYVLA +V + G S+L + + ++ L YE G++ I +L ++ K+VP I DP AL+ D ER C+ +
Sbjct: 45 FSVAEKLESPRFAQSGMV-REMKGENLTVGFLQQNGFNIPLLFKEKTGLGLQVPTANFSISDVRMCVGSRRLLDVMDVNTQKNVEMTMKEWEKYYEDPSKKKLLNVISLEFSHTKLENYVQSPAIVRQIDWVDVVWPKQLKESQVESTNLLNDMMYPKVQKYCLMSVKNCYTDFHVDFGGTSVWYHILRGSKVFWLIPPTEKNLQLYEKWVLSGKQSDVFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTDSLVFGGNFLHSFGIVKQLKITQVEDNTKVPQKFRYPFFTEMLWYVLAKYVYTLLGHSHLEGEPGREHELEGKPHVH-LTHYELFGLKDIVMYLYDLPAQK-KNVPELIRDPVALIKDVRTLVERHCRDV 424
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Match: A0A1I8IGT0 (JmjC domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 371.703 bits (953), Expect = 1.765e-120 Identity = 164/318 (51.57%), Postives = 228/318 (71.70%), Query Frame = 1
Query: 97 EYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVG 1050
+YD ID +W+L+ KL YS FV+ + G F L L+ +GF P+LF NK GLGL++P + F+V DV + VG R +DV+DV TQ A+ MTM+ W +YY +PN+ ++LNVISLE+S +KLD V +P VV Q+DW++ WP R+ +D + + T+ YPKVRKY LMSVA CYTD+H+D+GGTSVWYHI +G K+FW+ PPT N L+E+W LS Q + FF D++ +C++V L+PGNTF IP+GW+H VYTP DSLVFGGN+LHS +I LQL +W++EEK +V ++R+P F+++HWYVLA + G
Sbjct: 15 DYDPLIDGQ--REWDLEEKLNSTN-YSATFVDVRDTGEGFGLAELQRDGFRNPLLFKNKTGLGLRVPSESFNVADVKLMVGARRPVDVMDVRTQQALVMTMRQWTDYYTDPNRDRILNVISLEFSHTKLDNYVESPTVVRQIDWIDRAWPPYLREKQMDALNSMDTMFYPKVRKYVLMSVADCYTDWHVDMGGTSVWYHILRGRKVFWLVPPTERNFQLFEQWTLSGRQDATFFGDMVEKCQRVELEPGNTFFIPTGWMHAVYTPEDSLVFGGNYLHSLNIKLQLRVWELEEKTRVKRQFRFPLFMQLHWYVLARYAG 329
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Match: kdm2aa (lysine-specific demethylase 2A-like [Source:NCBI gene;Acc:103024695]) HSP 1 Score: 345.51 bits (885), Expect = 4.869e-105 Identity = 163/347 (46.97%), Postives = 233/347 (67.15%), Query Frame = 1
Query: 70 AKNAPSNLVEYDENI-DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
AK + + +D+ I DD + K ++L+ KL +R +S + V+R E G +F + ++ G PI+F DGLG+++P F+V+DV VG R++DV+DV TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TF+IPSGWIH VYTPVD+LVFGGNFLHSF+I +QL I+ +E++ +V TK+RYPF+ EM WYVL ++ + SYL ++
Sbjct: 16 AKRSGTRRRYHDDGISDDEIEGKRTFDLEEKLHSSR-FSSDRVKRME-GKNFTFEFIQRGGLRDPIIFERPDGLGIRMPDSTFTVNDVKNFVGSRRMIDVMDVATQKGIEMSMAQWWRYYETPPSQREKLYNVISLEFSHTKLEELVKRPSTVDIIDWVDNMWPRHLKERQRDSTNAILDMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDKATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNISMQLNIYSIEDRTRVPTKFRYPFYYEMCWYVLERYLYSLTNTSYLIPEFQKH 360
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Match: kdm2aa (lysine-specific demethylase 2A-like [Source:NCBI gene;Acc:103024695]) HSP 1 Score: 345.51 bits (885), Expect = 8.393e-105 Identity = 163/347 (46.97%), Postives = 233/347 (67.15%), Query Frame = 1
Query: 70 AKNAPSNLVEYDENI-DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
AK + + +D+ I DD + K ++L+ KL +R +S + V+R E G +F + ++ G PI+F DGLG+++P F+V+DV VG R++DV+DV TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TF+IPSGWIH VYTPVD+LVFGGNFLHSF+I +QL I+ +E++ +V TK+RYPF+ EM WYVL ++ + SYL ++
Sbjct: 16 AKRSGTRRRYHDDGISDDEIEGKRTFDLEEKLHSSR-FSSDRVKRME-GKNFTFEFIQRGGLRDPIIFERPDGLGIRMPDSTFTVNDVKNFVGSRRMIDVMDVATQKGIEMSMAQWWRYYETPPSQREKLYNVISLEFSHTKLEELVKRPSTVDIIDWVDNMWPRHLKERQRDSTNAILDMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDKATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNISMQLNIYSIEDRTRVPTKFRYPFYYEMCWYVLERYLYSLTNTSYLIPEFQKH 360
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Match: kdm2ab (lysine demethylase 2A [Source:NCBI gene;Acc:103039345]) HSP 1 Score: 345.125 bits (884), Expect = 1.092e-104 Identity = 150/300 (50.00%), Postives = 212/300 (70.67%), Query Frame = 1
Query: 202 NGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
+G DF + ++ G PI+F DGLG+++P +DFSV DV++ VG R++DV+DV TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYHI +G K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TFMIPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V +K+RYPF+ EM WYVL ++ + S+LT ++
Sbjct: 56 DGKDFTFEYIQQEGLRTPIIFTKTDGLGIQMPDEDFSVSDVNLFVGSRRMIDVMDVNTQKGIEMSMSQWRRYYETPPSEREKLYNVISLEFSHTKLEHLVKRPASVDVIDWVDNMWPRHLKEKQRDSTNAIIDMQYPKVQKYCLMSVKGCFTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDKATDCQRIELKQGYTFMIPSGWIHAVYTPEDTLVFGGNFLHSFNIPMQLNIYNIEDRTRVPSKFRYPFYYEMCWYVLERYLYSLTNTSHLTPEFQKH 355
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Match: kdm2ab (lysine demethylase 2A [Source:NCBI gene;Acc:103039345]) HSP 1 Score: 344.739 bits (883), Expect = 1.444e-104 Identity = 150/300 (50.00%), Postives = 212/300 (70.67%), Query Frame = 1
Query: 202 NGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
+G DF + ++ G PI+F DGLG+++P +DFSV DV++ VG R++DV+DV TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYHI +G K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TFMIPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V +K+RYPF+ EM WYVL ++ + S+LT ++
Sbjct: 56 DGKDFTFEYIQQEGLRTPIIFTKTDGLGIQMPDEDFSVSDVNLFVGSRRMIDVMDVNTQKGIEMSMSQWRRYYETPPSEREKLYNVISLEFSHTKLEHLVKRPASVDVIDWVDNMWPRHLKEKQRDSTNAIIDMQYPKVQKYCLMSVKGCFTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDKATDCQRIELKQGYTFMIPSGWIHAVYTPEDTLVFGGNFLHSFNIPMQLNIYNIEDRTRVPSKFRYPFYYEMCWYVLERYLYSLTNTSHLTPEFQKH 355
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Match: kdm2aa (lysine-specific demethylase 2A-like [Source:NCBI gene;Acc:103024695]) HSP 1 Score: 343.199 bits (879), Expect = 6.319e-104 Identity = 161/337 (47.77%), Postives = 229/337 (67.95%), Query Frame = 1
Query: 100 YDENI-DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQN 1095
+D+ I DD + K ++L+ KL +R +S + V+R E G +F + ++ G PI+F DGLG+++P F+V+DV VG R++DV+DV TQ I M+M W YY+ P + +L NVISLE+S +KL+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPTP NL LYE W LS +Q +F D +C+++ LK G TF+IPSGWIH VYTPVD+LVFGGNFLHSF+I +QL I+ +E++ +V TK+RYPF+ EM WYVL ++ + SYL ++
Sbjct: 21 HDDGISDDEIEGKRTFDLEEKLHSSR-FSSDRVKRME-GKNFTFEFIQRGGLRDPIIFERPDGLGIRMPDSTFTVNDVKNFVGSRRMIDVMDVATQKGIEMSMAQWWRYYETPPSQREKLYNVISLEFSHTKLEELVKRPSTVDIIDWVDNMWPRHLKERQRDSTNAILDMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLELYENWVLSGKQGDIFLGDKATDCQRIELKQGYTFIIPSGWIHAVYTPVDTLVFGGNFLHSFNISMQLNIYSIEDRTRVPTKFRYPFYYEMCWYVLERYLYSLTNTSYLIPEFQKH 355
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010169.1 (pep scaffold:Pmarinus_7.0:GL480870:6363:17942:-1 gene:ENSPMAG00000009200.1 transcript:ENSPMAT00000010169.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 281.567 bits (719), Expect = 1.256e-88 Identity = 135/297 (45.45%), Postives = 193/297 (64.98%), Query Frame = 1
Query: 142 LQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYV 1032
L+S++ P+ S + V +G L+ LE GF PIL KDGLG+ +PP F+V DV VG R++DV+DV Q ++ MT+ ++ +YY +PN Q++NVISLE+S ++L A+V P+VV L W+E+ WP +D++ P V KYCLM V YTDFHID GGTSVWYH+ KGEKIF++ PT NL+LYE+W LSS Q+ +FF D + +C + +K G T +IP+GWIHGV TPVD + FGGNFLH+ +I +QL + ++E+++K + +P F + WY
Sbjct: 96 LRSRMFPSN--SADDVLLKPHGSQLTLQYLEQAGFETPILVAKKDGLGMMVPPTSFTVSDVEQYVGSERLIDVIDVPRQASVKMTLGEFVQYYNSPNHGQVMNVISLEFSNTRLSALVEPPEVVRNLSWVENYWP-------LDSQ-----FPTPHVDKYCLMGVKDSYTDFHIDFGGTSVWYHVLKGEKIFYLIKPTNANLALYERWSLSSNQNEMFFGDQVDKCYRCTVKQGQTLLIPTGWIHGVLTPVDCIAFGGNFLHNLNIGMQLRVSEMEKRLKTADLFSFPNFETLLWYT 378
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010170.1 (pep scaffold:Pmarinus_7.0:GL480870:8586:17942:-1 gene:ENSPMAG00000009200.1 transcript:ENSPMAT00000010170.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 280.411 bits (716), Expect = 2.096e-88 Identity = 135/297 (45.45%), Postives = 193/297 (64.98%), Query Frame = 1
Query: 142 LQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYV 1032
L+S++ P+ S + V +G L+ LE GF PIL KDGLG+ +PP F+V DV VG R++DV+DV Q ++ MT+ ++ +YY +PN Q++NVISLE+S ++L A+V P+VV L W+E+ WP +D++ P V KYCLM V YTDFHID GGTSVWYH+ KGEKIF++ PT NL+LYE+W LSS Q+ +FF D + +C + +K G T +IP+GWIHGV TPVD + FGGNFLH+ +I +QL + ++E+++K + +P F + WY
Sbjct: 91 LRSRMFPSN--SADDVLLKPHGSQLTLQYLEQAGFETPILVAKKDGLGMMVPPTSFTVSDVEQYVGSERLIDVIDVPRQASVKMTLGEFVQYYNSPNHGQVMNVISLEFSNTRLSALVEPPEVVRNLSWVENYWP-------LDSQ-----FPTPHVDKYCLMGVKDSYTDFHIDFGGTSVWYHVLKGEKIFYLIKPTNANLALYERWSLSSNQNEMFFGDQVDKCYRCTVKQGQTLLIPTGWIHGVLTPVDCIAFGGNFLHNLNIGMQLRVSEMEKRLKTADLFSFPNFETLLWYT 373
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003484.1 (pep scaffold:Pmarinus_7.0:GL479346:7845:35819:-1 gene:ENSPMAG00000003183.1 transcript:ENSPMAT00000003484.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 228.409 bits (581), Expect = 5.764e-69 Identity = 115/295 (38.98%), Postives = 168/295 (56.95%), Query Frame = 1
Query: 151 KLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNL-SLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYV 1032
KL+ S V R G + NGF+ PI+ KDGLG+ +PP F+V DV VG R++DV+DV Q +TMK++CEYY + ++ ++LN+ISLE+S ++L +V+AP++V +L W+E+ WPE P V+KYCLM V YTDFHID GGTSVWYH+ K E F+ T +L + + +C S Q+ FF D+ C + + +GWIH V TP D + FGGNFLHS ++ +Q+ +D+E ++K +++P F M WY
Sbjct: 47 KLQGRSFPSAEEVVRRMPGSQLTADYIIENGFTSPIIVSKKDGLGMTVPPPSFTVSDVERYVGSDRMIDVIDVNRQADFKVTMKEFCEYYNSTSRQKVLNIISLEFSDTRLSDLVKAPELVHKLSWVENYWPED------------AVFPRPYVQKYCLMGVRDSYTDFHIDFGGTSVWYHLLKAEFFFFFLETTAISLNARFVCYCSSFSQNRQFFSDVAVHCTRSPVARVGVMCARTGWIHAVLTPYDCIAFGGNFLHSLNVEMQIRAYDIETRLKTPEVFKFPNFESMCWYA 329
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Yeast
Match: JHD1 (JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe [Source:SGD;Acc:S000000853]) HSP 1 Score: 167.548 bits (423), Expect = 9.828e-46 Identity = 101/293 (34.47%), Postives = 165/293 (56.31%), Query Frame = 1
Query: 307 FSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP---NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWL 1176
+V+ ++ +G+ +DV+DV++Q + W EY+ N + ++ NVISLE S + + R P V Q D ++ W V+ + + PKV KY LMSV YTDFH+D GTSV+Y++ G+K F + PPT N+ Y +W L +Q+S+F D++ + + L G+ FMIP+G+IH VYTPVDSLVFGGNFL + L I ++E+ KV ++ +P F ++ +G++ YL +L++NK S V+ + L++ + I+S+ ++
Sbjct: 186 LTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEYFTNTEPDRRDRIRNVISLEVSNIEGLELER-PTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEKLTKVPRRFTFPKFDQV--------MGKL--CEYL--ALDKNKITSDVSDGDLLSRTTNCAIQSLHAYV 465
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Nematostella
Match: EDO41168 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S527]) HSP 1 Score: 335.109 bits (858), Expect = 1.194e-102 Identity = 154/317 (48.58%), Postives = 219/317 (69.09%), Query Frame = 1
Query: 103 DENIDDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFV 1047
D + DD + K ++L+ KL N V+ + + +G +F+LK ++ NGF PILF + +GL +K+P +F+V DV VG R++DV+DV TQ + +T+++W +Y+ NP + ++ NVISLE+S +KL +V +P VV Q+DW+++ WP + D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYH+ KG+KIFW+ PPT NL YE+W LS +Q FF D + +C +V L G+TF+IP+GWIH VYTP DSLVFGGNF+HS+SI Q+ I +E+ KV K+RYPF+ EM WYV +V
Sbjct: 21 DTSQDDEIEGKRTFSLEEKL-ANPVFEADSFVQMLDGNEFSLKYVQSNGFKTPILFKSTEGLDMKIPDAEFTVTDVKNFVGARRLVDVIDVNTQQPLELTLQNWVKYFTNPEREKIYNVISLEFSHTKLQDLVESPLVVRQIDWVDTVWPRNLIEEQRDSTNSMADMKYPKVKKYCLMSVGGCYTDFHIDFGGTSVWYHLMKGKKIFWLIPPTERNLQQYERWVLSGKQQDFFFGDQVEKCSRVTLVSGDTFLIPTGWIHAVYTPDDSLVFGGNFIHSYSISEQIRISQIEDNTKVPQKFRYPFYAEMMWYVAEKYV 336
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Nematostella
Match: EDO39503 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9X9]) HSP 1 Score: 300.442 bits (768), Expect = 1.320e-95 Identity = 151/355 (42.54%), Postives = 209/355 (58.87%), Query Frame = 1
Query: 202 NGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAERACK 1266
+G D + E NGF KP+L DGL + +P F + DV VG R LDV+DV Q I M M++W EYY NP + + LNVISLE+S + + ++V P +V +LDW WP + K Y V+KYCLMSV+ CYTDFH+D GGTSVWYH+FKGEK+F+ PTP NL Y +W +SS QS +FF D++ +C KV +K G T IP+GWIH VYTPVDSLVFGGNFLHSF+I LQL I+D+E K+K K+++PF+ ++W+ + ++ GI + QY G++ + ++LK+ + F +P I P L+ + K
Sbjct: 111 HGRDLTVDYFERNGFQKPLLIDKTDGLNIVVPKPGFDIPDVEKYVGSMRELDVIDVCKQEDIKMRMREWTEYYMNPVRKKTLNVISLEFSNTPMSSLVHVPAIVKELDWANHVWPTDLPEDSPHKKPY--------VQKYCLMSVSNCYTDFHVDFGGTSVWYHVFKGEKVFYFVEPTPANLEKYHQWVMSSTQSEIFFGDMVKKCYKVQIKQGQTLFIPTGWIHAVYTPVDSLVFGGNFLHSFNIGLQLEIYDLELKLKTPNKFQHPFYETINWFAAVFLLDKLKGIQEIGGR---------------PPQYLVKGMQDLVEYLKKWTHHKF-YIPEGI-QPGKLIRSINKELK 440
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Match: kdm2ab (lysine demethylase 2A [Source:NCBI gene;Acc:101164160]) HSP 1 Score: 347.436 bits (890), Expect = 1.629e-105 Identity = 159/330 (48.18%), Postives = 226/330 (68.48%), Query Frame = 1
Query: 115 DDVVLTK--WNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQ 1092
DD + K ++L+ KL+ + G+ + +Y G DF + ++ G PI+F DGLGL++P DFSV DV + VG RI+DV+DV TQ I M+M W YY+ P + +L NVISLE+S ++L+ +V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GC+TDFHID GGTSVWYHI +G K+FW+ PPTP NL +YE W LS +Q +F D +C+++ LK GNTF+IPSGWIH VYTP D+LVFGGNFLHSF+IP+QL I+++E++ +V K+RYPF+ EM WYVL ++ + IS+LT +
Sbjct: 27 DDEIEGKRTFDLEEKLQCGKF--GSELIKYMKGKDFTFEYIQREGLRDPIVFETSDGLGLQMPDSDFSVSDVKLFVGSRRIVDVMDVNTQKGIEMSMAQWRRYYETPPSEREKLYNVISLEFSHTRLENLVKRPASVDLIDWVDNMWPRHLKERQRDSTNAIIDMHYPKVQKYCLMSVQGCFTDFHIDFGGTSVWYHILRGGKVFWLIPPTPQNLEMYENWVLSGKQGDIFLGDKCCDCQRIELKQGNTFIIPSGWIHAVYTPEDTLVFGGNFLHSFNIPMQLNIYNIEDRTRVPAKFRYPFYYEMCWYVLERYLYCLTNISHLTPEFQK 354
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Match: kdm2aa (lysine-specific demethylase 2A [Source:NCBI gene;Acc:101171056]) HSP 1 Score: 344.354 bits (882), Expect = 1.226e-104 Identity = 166/353 (47.03%), Postives = 234/353 (66.29%), Query Frame = 1
Query: 103 DENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQ-NKSISKVNSINTLNQYESNG 1152
DE ID + ++L+ K+ R ++ + + R E G DF+ + ++ G PI+F GLGL++P DFSV+DV + VG R++DV+DV TQ M+M W YY+ P + +L NVISLE+S +KLD++V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D ++ C+++ LK G T +IPSGWIH VYTPVDS+VFGGNFLHSF+IP+QL I ++E++ +V K+RYPFF EM WYVL +V + SYLT + + SI S + ++ E G
Sbjct: 27 DEEIDGRRM--FDLEEKVTSQR-FTSDKILRME-GKDFSYEYVQKEGLRDPIVFEKPAGLGLRMPDLDFSVNDVKLFVGSRRMIDVMDVSTQKGTEMSMAQWTRYYETPPSQREKLYNVISLEFSHTKLDSLVQRPTTVDLIDWVDNMWPRHLKERQRDSTNSISDMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTHPNLELYENWVLSGKQGDIFLGDRVSNCQRIELKQGWTLIIPSGWIHAVYTPVDSMVFGGNFLHSFNIPMQLNICNIEDRTRVPVKFRYPFFYEMCWYVLERYVYCLTRTSYLTPEFQKYSLSIGLKKSPSGSSEQEQGG 375
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Match: kdm2aa (lysine-specific demethylase 2A [Source:NCBI gene;Acc:101171056]) HSP 1 Score: 344.354 bits (882), Expect = 1.273e-104 Identity = 166/353 (47.03%), Postives = 234/353 (66.29%), Query Frame = 1
Query: 103 DENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNP--NKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQ-NKSISKVNSINTLNQYESNG 1152
DE ID + ++L+ K+ R ++ + + R E G DF+ + ++ G PI+F GLGL++P DFSV+DV + VG R++DV+DV TQ M+M W YY+ P + +L NVISLE+S +KLD++V+ P V +DW+++ WP ++ D+ + + + YPKV+KYCLMSV GCYTDFHID GGTSVWYHI +G K+FW+ PPT NL LYE W LS +Q +F D ++ C+++ LK G T +IPSGWIH VYTPVDS+VFGGNFLHSF+IP+QL I ++E++ +V K+RYPFF EM WYVL +V + SYLT + + SI S + ++ E G
Sbjct: 17 DEEIDGRRM--FDLEEKVTSQR-FTSDKILRME-GKDFSYEYVQKEGLRDPIVFEKPAGLGLRMPDLDFSVNDVKLFVGSRRMIDVMDVSTQKGTEMSMAQWTRYYETPPSQREKLYNVISLEFSHTKLDSLVQRPTTVDLIDWVDNMWPRHLKERQRDSTNSISDMQYPKVQKYCLMSVQGCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTHPNLELYENWVLSGKQGDIFLGDRVSNCQRIELKQGWTLIIPSGWIHAVYTPVDSMVFGGNFLHSFNIPMQLNICNIEDRTRVPVKFRYPFFYEMCWYVLERYVYCLTRTSYLTPEFQKYSLSIGLKKSPSGSSEQEQGG 365
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Match: kdm2bb (lysine-specific demethylase 2B [Source:NCBI gene;Acc:101163098]) HSP 1 Score: 327.405 bits (838), Expect = 6.898e-98 Identity = 154/339 (45.43%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 100 YDENID--DVV----LTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN--KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQ 1092
YDEN D DV + ++++ KL +R Y+ +FV E G DF + ++ P++F K LG+++P +F+V ++ VG R +DV+DV TQ M+M + YY+ P + +L NVISLE+S +KL+ +++ P VV Q+DW+++ WP + + + + + YPKV++YCLMSV GCYTDFHID GGTSVWYH+FKG+K+FW+ PPTP NL+LYE W LS +QS +F D C++V L+ G TF IPSGWIH VYTP+D+LVFGGN LHSF+IP+QL I ++E + KV +K+R+PF+ E+ WYV+ + + SYL+ L++
Sbjct: 24 YDENEDFSDVEEIENVRGFSVEEKLASDR-YTADFVHLME-GKDFTYEYVQKEALRTPLIFKEKAELGIRMPDPEFTVSEIKGLVGSRRSVDVMDVSTQKGSEMSMAQFVRYYETPEEERDKLFNVISLEFSHTKLENLIKRPTVVDQVDWVDNMWPPDLKQSQTEATNIISEMKYPKVQRYCLMSVKGCYTDFHIDFGGTSVWYHVFKGQKVFWLVPPTPYNLALYEDWVLSGKQSDVFLGDRADGCQRVELRQGYTFFIPSGWIHAVYTPMDALVFGGNILHSFNIPMQLTIHEIENRTKVHSKFRFPFYYEICWYVVERYFHCLTKRSYLSQDLHR 360
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Match: phf8 (PHD finger protein 8 [Source:NCBI gene;Acc:101166128]) HSP 1 Score: 278.87 bits (712), Expect = 8.173e-82 Identity = 124/288 (43.06%), Postives = 185/288 (64.24%), Query Frame = 1
Query: 202 NGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGI 1065
+G ++ LE + FS P++ + +DGLG+ LPP FSV D+ ++G + +DV+DV Q + M + D+ EYY +PN+ ++LNVISLE+S+++L +V P +V +L W+E+ WPE+ P V+KYCLM V YTDFHID GGTSVWYH+ +GEKIF++ PTP NL+L+E+W SS Q+ +FF D + C K +K GNT IP+GWIH V TPVD L FGGNFLHS +I +Q+ +++E+++ +++P F + WY + + G+
Sbjct: 113 SGAQLTVEFLEEHSFSVPVMVLRRDGLGMTLPPASFSVSDIEHHIGPDKEIDVIDVCRQCDLKMRLGDFVEYYNSPNRDRVLNVISLEFSETRLSNLVETPKIVRKLSWVENLWPEES------------VFERPNVQKYCLMGVKDSYTDFHIDFGGTSVWYHVLRGEKIFYLISPTPANLALFEQWNSSSNQNEMFFGDQVDMCYKCSVKQGNTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIDMQIRAYEIEKRLSTAELFKFPNFETVCWYAGKHLLDTLRGL 388
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Match: SMESG000053144.1 (SMESG000053144.1) HSP 1 Score: 1025 bits (2649), Expect = 0.000e+0 Identity = 509/512 (99.41%), Postives = 510/512 (99.61%), Query Frame = 1
Query: 49 MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAERACKSIILDSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTXXXXXXXXXXXQRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN 1584
MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP DDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAE ACKSII+DSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTKSKSKSRKSNKQRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN
Sbjct: 1 MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPHDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAEHACKSIIVDSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTKSKSKSRKSNKQRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN 512
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Match: SMESG000053144.1 (SMESG000053144.1) HSP 1 Score: 1020.76 bits (2638), Expect = 0.000e+0 Identity = 507/513 (98.83%), Postives = 509/513 (99.22%), Query Frame = 1
Query: 49 MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAERACKSIILDSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTXXXXXXXXX-XXQRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN 1584
MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLP DDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAE ACKSII+DSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTKSKSKSRKS +QRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN
Sbjct: 1 MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYENGWDFNLKTLELNGFSKPILFVNKDGLGLKLPHDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPNKTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRINGISYLTSSLNQNKSISKVNSINTLNQYESNGIRSICKWLKEISLDTFKSVPNDIADPAALLSDAEHACKSIIVDSNSFNHAESFITSAKSEQKTGQINNNIDLGLLSSNSKYMKLEIVPLTKSKSKSRKSNKQQRHGKPKIEITAEIPHSLYNQITQRTGSRQIVRPNRLVENPFN 513
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Match: SMESG000017771.1 (SMESG000017771.1) HSP 1 Score: 236.498 bits (602), Expect = 5.153e-71 Identity = 115/284 (40.49%), Postives = 174/284 (61.27%), Query Frame = 1
Query: 238 NGFSKPILFVNKDGLGLKLPPDDFSVDDVSINVGKSRILDVVDVETQNAIGMTMKDWCEYYKNPN-KTQLLNVISLEYSQSKLDAIVRAPDVVLQLDWLESCWPEKCRDIHVDNKSYLKTLTYPKVRKYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPPTPDNLSLYEKWCLSSEQSSLFFPDLI--------AECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPLQLAIWDVEEKIKVGTKYRYPFFIEMHWYVLAAFVGRING 1062
NGF+KPI+ K GL + LP FSV+DV N+GK ILDV+DV Q+ M ++ +Y++ +++LLNV+SLE S +K+ +V P V+ ++ +E WP C +++ + P V+KYCLMS+ +TDFHID GG+SVWYH++ G KIF++ PP + Y W LFFPD I AE ++ +K G+T ++P+GWIH V+T DSLVFGGNF+HS SIPLQL I+ +E ++ ++ +P+F ++HW+V + ++
Sbjct: 41 NGFNKPIMIRRKKGLRIVLPESPFSVEDVGRNLGKDYILDVIDVVQQDQYKMRFGEFLDYFRESEPRSKLLNVLSLEISHTKIAHLVEPPYVIKEMSIVEKLWP--CDNLY-------QRANKPSVQKYCLMSMKDSWTDFHIDFGGSSVWYHMYSGHKIFYLIPPKRRYIKAYTSWMGEYNNRMLFFPDQIKKFSLNDQAEVYRLEIKSGDTILLPAGWIHAVHTLEDSLVFGGNFVHSLSIPLQLKIYKIERFLQTEDRFLFPYFEKLHWFVAEYILHKLEA 315
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Match: SMESG000022043.1 (SMESG000022043.1) HSP 1 Score: 50.8322 bits (120), Expect = 1.894e-6 Identity = 38/124 (30.65%), Postives = 55/124 (44.35%), Query Frame = 1
Query: 616 KYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPP-TPD---NLSLYEKWCLSSEQSSLF--------FPDLIAECEKVHL--KPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPL 945
++ +M A T HID GTS W + KG K + + PP TP L+ E W SE F P+ +E + + + PG T +P GW H V D++ NF S + P+
Sbjct: 183 RWFVMGSARSGTGIHIDPLGTSAWNALVKGHKRWCLFPPSTPKELLKLNSNEGWKNRSEAIVWFSIVYPRCKAPNWPSEFKMIEILQNPGETVFVPGGWWHVVLNLDDTVAVTQNFCSSSNFPV 306
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Match: SMESG000039333.1 (SMESG000039333.1) HSP 1 Score: 48.9062 bits (115), Expect = 7.791e-6 Identity = 35/125 (28.00%), Postives = 55/125 (44.00%), Query Frame = 1
Query: 616 KYCLMSVAGCYTDFHIDLGGTSVWYHIFKGEKIFWIAPP-TPDNL---SLYEKWCLSSEQSSLF-----------FPDLIAECEKVHLKPGNTFMIPSGWIHGVYTPVDSLVFGGNFLHSFSIPL 945
++ ++ A ++ HID GTS W + G K + + PP TP L + + W +E S F +P A E + KPG T +PSGW H V ++ NF + + P+
Sbjct: 184 RWFVIGSARSGSNIHIDPLGTSAWNALVHGYKRWCLFPPCTPKFLVKPPINKNWGRLTEASDWFNIMYKRMLLSDWPSEYAMTEAIQ-KPGETIFVPSGWWHVVLNLTTTVAITQNFCSTINFPI 307 The following BLAST results are available for this feature:
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 4
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of JmjC domain-containing histone demethylation 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of JmjC domain-containing histone demethylation 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30000627 ID=SMED30000627|Name=JmjC domain-containing histone demethylation 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1879bpback to top protein sequence of SMED30000627-orf-1 >SMED30000627-orf-1 ID=SMED30000627-orf-1|Name=SMED30000627-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=513bp MSTKIRIAKNAPSNLVEYDENIDDVVLTKWNLQSKLEPNRVYSGNFVERYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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