Lethal(2) giant larvae-like protein

Overview


Name	Lethal(2) giant larvae-like protein
Smed ID	SMED30000608
Length (bp)	3037

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Lethal(2) giant larvae-like protein (SMED30000608) t-SNE clustered cells

Violin plots show distribution of expression levels for Lethal(2) giant larvae-like protein (SMED30000608) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Lethal(2) giant larvae-like protein (SMED30000608) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Lethal(2) giant larvae-like protein (SMED30000608) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30000608

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
parapharyngeal region	SMED30000608	SMESG000039127.1 SMESG000039124.1	dd_Smed_v4_11211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Match: LLGL2 (LLGL scribble cell polarity complex component 2 [Source:HGNC Symbol;Acc:HGNC:6629])

HSP 1 Score: 63.929 bits (154), Expect = 1.397e-9
Identity = 53/180 (29.44%), Postives = 82/180 (45.56%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNG-----LKDKNKILVLTTTECVVISRDNGVW 1096
            N++LI +  + G V+  D +   + + FL   Q       +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T         D   ++VL   E VVI      W
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSSQQ-----LENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Match: LLGL2 (LLGL scribble cell polarity complex component 2 [Source:HGNC Symbol;Acc:HGNC:6629])

HSP 1 Score: 63.5438 bits (153), Expect = 1.716e-9
Identity = 53/180 (29.44%), Postives = 82/180 (45.56%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNG-----LKDKNKILVLTTTECVVISRDNGVW 1096
            N++LI +  + G V+  D +   + + FL   Q       +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T         D   ++VL   E VVI      W
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSSQQ-----LENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Match: LLGL2 (LLGL scribble cell polarity complex component 2 [Source:HGNC Symbol;Acc:HGNC:6629])

HSP 1 Score: 63.5438 bits (153), Expect = 1.775e-9
Identity = 53/180 (29.44%), Postives = 82/180 (45.56%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNG-----LKDKNKILVLTTTECVVISRDNGVW 1096
            N++LI +  + G V+  D +   + + FL   Q       +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T         D   ++VL   E VVI      W
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSSQQ-----LENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Match: LLGL2 (LLGL scribble cell polarity complex component 2 [Source:HGNC Symbol;Acc:HGNC:6629])

HSP 1 Score: 57.3806 bits (137), Expect = 8.078e-8
Identity = 46/148 (31.08%), Postives = 75/148 (50.68%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVIT 1015
            N++LI +  + G V+  D +   + + FL   Q++E    +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSS-QQLE----NIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLT 339

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Match: LLGL2 (LLGL scribble cell polarity complex component 2 [Source:HGNC Symbol;Acc:HGNC:6629])

HSP 1 Score: 57.3806 bits (137), Expect = 8.078e-8
Identity = 46/148 (31.08%), Postives = 75/148 (50.68%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVIT 1015
            N++LI +  + G V+  D +   + + FL   Q++E    +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSS-QQLE----NIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLT 339

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Match: l(2)gl (gene:FBgn0002121 transcript:FBtr0078169)

HSP 1 Score: 58.151 bits (139), Expect = 4.526e-8
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  200 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 282

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Match: l(2)gl (gene:FBgn0002121 transcript:FBtr0078167)

HSP 1 Score: 58.151 bits (139), Expect = 4.526e-8
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  200 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 282

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Match: l(2)gl (gene:FBgn0002121 transcript:FBtr0078168)

HSP 1 Score: 58.151 bits (139), Expect = 4.526e-8
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  200 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 282

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Match: l(2)gl (gene:FBgn0002121 transcript:FBtr0306592)

HSP 1 Score: 58.151 bits (139), Expect = 4.734e-8
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  249 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 331

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Match: l(2)gl (gene:FBgn0002121 transcript:FBtr0306590)

HSP 1 Score: 58.151 bits (139), Expect = 4.734e-8
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  249 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 331

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Zebrafish
Match: llgl1 (LLGL scribble cell polarity complex component 1 [Source:ZFIN;Acc:ZDB-GENE-060825-69])

HSP 1 Score: 53.9138 bits (128), Expect = 1.243e-6
Identity = 64/234 (27.35%), Postives = 99/234 (42.31%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVI--TNGLKD---KNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEV---------------------ENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTW-----FLTPDQCFLSESV-NLNKFYNSSSTEKQEKNILWPRFQKCG 1414
            PYGPFPCK+++K L     SG      +FSGGMP  +Y D + +++ ++D   +   F   V+DF  I  T+  KD    + ++VL   E VVI      W +     + P   S IT   +I  V                     EN+ I     ++ D K        Q +L    +++G+V  W      L P     + S+   +  +N S T+  E+   WP F+K G
Sbjct:  277 PYGPFPCKAVNKILWRTTESGA--PLVLFSGGMPRASYGDRHCLTI-LQDSSHVTLDFTSRVIDFFTIHCTDTEKDFDEPSALVVLLEEELVVIDLQMPGWPTVPAPYLAPLHSSAITCSCHISNVPPKLWERVISAGQQQCPLQNYENWPICGGKNLAPDPK--------QKELLLTGHEDGTVRFWDASGVSLKPLYKLSTASIFQTDCEHNDSLTQAGEEE--WPPFRKVG 497

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Zebrafish
Match: llgl1 (LLGL scribble cell polarity complex component 1 [Source:ZFIN;Acc:ZDB-GENE-060825-69])

HSP 1 Score: 53.9138 bits (128), Expect = 1.245e-6
Identity = 64/235 (27.23%), Postives = 99/235 (42.13%), Query Frame = 2

Query:  809 FPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVI--TNGLKD---KNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEV---------------------ENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTW-----FLTPDQCFLSESV-NLNKFYNSSSTEKQEKNILWPRFQKCG 1414
             PYGPFPCK+++K L     SG      +FSGGMP  +Y D + +++ ++D   +   F   V+DF  I  T+  KD    + ++VL   E VVI      W +     + P   S IT   +I  V                     EN+ I     ++ D K        Q +L    +++G+V  W      L P     + S+   +  +N S T+  E+   WP F+K G
Sbjct:  249 IPYGPFPCKAVNKILWRTTESGA--PLVLFSGGMPRASYGDRHCLTI-LQDSSHVTLDFTSRVIDFFTIHCTDTEKDFDEPSALVVLLEEELVVIDLQMPGWPTVPAPYLAPLHSSAITCSCHISNVPPKLWERVISAGQQQCPLQNYENWPICGGKNLAPDPK--------QKELLLTGHEDGTVRFWDASGVSLKPLYKLSTASIFQTDCEHNDSLTQAGEEE--WPPFRKVG 470

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
Match: Llgl2 (LLGL2 scribble cell polarity complex component [Source:MGI Symbol;Acc:MGI:1918843])

HSP 1 Score: 56.9954 bits (136), Expect = 1.422e-7
Identity = 34/101 (33.66%), Postives = 48/101 (47.52%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITN-----GLKDKNKILVLTTTECVVISRDNGVW 1096
            PYGPFPCK+I K        G+     +F GGMP  +Y D + +SV + +  +  F F   V+DF V++         D   ++VL   E VVI      W
Sbjct:  274 PYGPFPCKAITKIFWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
Match: Llgl2 (LLGL2 scribble cell polarity complex component [Source:MGI Symbol;Acc:MGI:1918843])

HSP 1 Score: 56.9954 bits (136), Expect = 1.455e-7
Identity = 34/101 (33.66%), Postives = 48/101 (47.52%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITN-----GLKDKNKILVLTTTECVVISRDNGVW 1096
            PYGPFPCK+I K        G+     +F GGMP  +Y D + +SV + +  +  F F   V+DF V++         D   ++VL   E VVI      W
Sbjct:  274 PYGPFPCKAITKIFWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
Match: Llgl1 (LLGL1 scribble cell polarity complex component [Source:MGI Symbol;Acc:MGI:102682])

HSP 1 Score: 53.5286 bits (127), Expect = 1.407e-6
Identity = 34/99 (34.34%), Postives = 51/99 (51.52%), Query Frame = 2

Query:  725 ENNQILISTFDGKFGIIDMEA-----FNKDLLIFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            + + I+ S  DG + I   +          ++  PYGPFPCK+I+K L  +  SG  +   +FSGGMP  +Y D + VSV +  E  +   F   V+DF
Sbjct:  247 DGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESG--DHFIIFSGGMPRASYGDRHCVSV-LRAETLVTLDFTSRVIDF 342

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
Match: Llgl1 (LLGL1 scribble cell polarity complex component [Source:MGI Symbol;Acc:MGI:102682])

HSP 1 Score: 53.5286 bits (127), Expect = 1.484e-6
Identity = 34/99 (34.34%), Postives = 51/99 (51.52%), Query Frame = 2

Query:  725 ENNQILISTFDGKFGIIDMEA-----FNKDLLIFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            + + I+ S  DG + I   +          ++  PYGPFPCK+I+K L  +  SG  +   +FSGGMP  +Y D + VSV +  E  +   F   V+DF
Sbjct:  247 DGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESG--DHFIIFSGGMPRASYGDRHCVSV-LRAETLVTLDFTSRVIDF 342

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Match: sp|Q5RCX2|L2GL2_PONAB (LLGL scribble cell polarity complex component 2 OS=Pongo abelii OX=9601 GN=LLGL2 PE=2 SV=1)

HSP 1 Score: 66.2402 bits (160), Expect = 1.228e-9
Identity = 56/180 (31.11%), Postives = 82/180 (45.56%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKFGIIDM--EAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITN-----GLKDKNKILVLTTTECVVISRDNGVW 1096
            N++LI +  + G V+  D +   + + FL   Q       +I    + ++L+S   DG +    M  EA   + L  + PYGPFPCK+I K L      G+     +F GGMP  +Y D +  SV I D  +  F F   V+DF V+T         D   ++VL   E VVI      W
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSSQQ-----LENIWWQRDGRLLVSCHSDGSYCQWPMSSEAQQPEPLRSLVPYGPFPCKAITKILWLTTRQGL--PFTIFQGGMPRASYGDRHCTSV-IHDGQQTAFDFTSRVIDFTVLTEADPAAAFDDPYALVVLAEEELVVIDLQTAGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Match: sp|Q6P1M3|L2GL2_HUMAN (LLGL scribble cell polarity complex component 2 OS=Homo sapiens OX=9606 GN=LLGL2 PE=1 SV=2)

HSP 1 Score: 63.5438 bits (153), Expect = 8.242e-9
Identity = 53/180 (29.44%), Postives = 82/180 (45.56%), Query Frame = 2

Query:  590 NKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKF--GIIDMEAFNKDLL--IFPYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNG-----LKDKNKILVLTTTECVVISRDNGVW 1096
            N++LI +  + G V+  D +   + + FL   Q       +I    + ++L+S   DG +    +  EA   + L  + PYGPFPCK+I + L      G+     +F GGMP  +Y D + +SV I D  +  F F   V+ F V+T         D   ++VL   E VVI      W
Sbjct:  202 NQILIGY--SRGLVVIWDLQGSRVLYHFLSSQQ-----LENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Match: sp|Q08470|L2GL_DROPS (Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura OX=46245 GN=l(2)gl PE=1 SV=3)

HSP 1 Score: 60.4622 bits (145), Expect = 7.668e-8
Identity = 37/107 (34.58%), Postives = 54/107 (50.47%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIK--EKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTE 1063
            DG +    ID     +++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV + D  ++C  F   V+DF V      D  ++L++   E
Sbjct:  249 DGSYATWSIDNGEPPQNVNYVPYGPDPCKSINR----LYKGQRGTNDVIVFSGGMPRSAYGDHNCVSVHVSDGHKVCLDFTSKVIDFFVTYKEGSDDVEVLIVLLEE 351

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Match: sp|P08111|L2GL_DROME (Lethal(2) giant larvae protein OS=Drosophila melanogaster OX=7227 GN=l(2)gl PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 4.745e-7
Identity = 33/87 (37.93%), Postives = 44/87 (50.57%), Query Frame = 2

Query:  755 DGKFGI--IDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEK--CYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF 1003
            DG +    ID      ++   PYGP PCKSI++    ++ G +      VFSGGMP   Y D N VSV   D  ++C  F   V+DF
Sbjct:  249 DGSYATWSIDNPEPPSNVNYVPYGPDPCKSINR----LYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDF 331

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Match: sp|Q3TJ91|L2GL2_MOUSE (LLGL scribble cell polarity complex component 2 OS=Mus musculus OX=10090 GN=Llgl2 PE=1 SV=2)

HSP 1 Score: 56.9954 bits (136), Expect = 9.944e-7
Identity = 34/101 (33.66%), Postives = 48/101 (47.52%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCL-TAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITN-----GLKDKNKILVLTTTECVVISRDNGVW 1096
            PYGPFPCK+I K        G+     +F GGMP  +Y D + +SV + +  +  F F   V+DF V++         D   ++VL   E VVI      W
Sbjct:  274 PYGPFPCKAITKIFWLTTRQGL--PFTIFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGW 371

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Match: A0A433UAG8 (WD_REPEATS_REGION domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_001417 PE=4 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 3.945e-15
Identity = 97/363 (26.72%), Postives = 164/363 (45.18%), Query Frame = 2

Query:   80 GKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKIS--HLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYKLELDS--RLFITSICECKNVVFENFSSENIPILIGCNNGAIEMCVVK---ETHVVRSNVI---KPEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTF-DGKFGIIDMEAFN----KDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNG---------LKDKNKILVLTTTECVVISRDNGVW 1096
            G  ++    A + KL+L ++ ++ G+I IF      +     G +S   + F+ ++G L+    +  LH W  NN   S   +  + E+DS   L + S+  C   +  +FSS    + +G  +G + +  VK   ETHV+  + I    PE F     K+    V  +A+  +      +KVLI F    G ++  ++++      F    Q++E+    +    N +  IS   DG +  I  EA N    K+  + PYGPFPCK+++K L  +     E   VFSGGMP  +Y D +TVS+    +  +       VVDF +I+             D   +++L   E VV+  ++  W
Sbjct:   33 GFPTKPSAMAYDSKLQLLAIGTKSGVIRIFGTPGFEVSATHEGDVSVTSIFFIPEEGRLITACSDSSLHLWEINNRDGSS--VLEEKEMDSGEALKVKSMSTCS--MSSDFSS----LFVGTESGNVHVIDVKTLTETHVINMDTIIQNVPEDF-----KVSPGAVEATASNPVN----SDKVLIGF--NRGLIVLWNTKDGAAEATF-NATQQLEY----LTWSRNGEEFISAHNDGSY--ITWEAKNSAEPKEQALTPYGPFPCKAVNKLLWKMTK--NEPMVVFSGGMPRASYGDRHTVSIMQGGDNHVVADLTSRVVDFIIISRADEKDAIETDRDDPRALVILAEEELVVLDLESEGW 367

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Match: A0A158PLD8 (LLGL domain-containing protein OS=Angiostrongylus costaricensis OX=334426 GN=ACOC_LOCUS11235 PE=4 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.875e-13
Identity = 124/542 (22.88%), Postives = 213/542 (39.30%), Query Frame = 2

Query:   80 GKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGK------ISHLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYKLELDSRLFITSICECKNVVFENFSSENIPILIGCNNG---AIEMCVVK--ETHVVRSNVIK--PEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQI-LISTFDGKFGIIDM---EAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKD---------------KNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQIT----RMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLT-PDQCFLSESVNLNKFYNSSSTEK----QEKNIL--------------WPRFQKCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVD 1540
            G  S   CFA ++ L L ++ S DG I I+  +  +   +  GK      ++H+ F S  G L+    +     +       S   + ++  L     ITS C     + E  + ++  +LIG  +G   A+++  ++  E  V    +++  PE     K  +D +L     N  LTI+   ++ LI ++          + NE++      +  K      +I    N  + +++  DG +   +        +  L+F  GPFPC    K   A  S   E+  +FSGGMP  +Y D  TV+    D     F F+  V+DF +   G  D                   LVLT  E V I   +  W      QMFP   SQI     R++       + ++    +S + +  K     Q  L+   ++NG+V  W     D   L      N+F+  S  +K    +E  +               WP F+K G +   F +  S+   K++ D  +S H++I      + L+ ++
Sbjct:   31 GFPSHVSCFAYDKVLSLLAIGSLDGDINIYGGNGYMWSTEIPGKKGIGKSVAHMYFASGLGVLIVLCRDATFVRFSLEGSQLSARSVLHETRLKK---ITSCC-----MMERVNIQDAMLLIGTVSGNVFALDITTLELSEYIVFEDALLQRIPESSRREKYPVD-LLSVCPTNPRLTIMVFDHRHLIAYD---------SARNEVMGSSTFDVQCK------NITWSRNGGVFVVALHDGSYASCNPTTGAVIERPPLVF--GPFPCTPAKKAFLAETSSSSERIVLFSGGMPHASYGDRFTVTARQADR-TCVFDFSSPVIDFLLTYGGELDFCLCIFVQCPPSDSYHTCALVLTENELVCIDLRDRYWRVIATEQMFPLHASQIAAEAVRLNRKYSTGKWPLNARIPVSGETRSGKEVTKRQ--LYLTGHENGTVRVWCAGHADMKLLFVIDTRNEFHGFSEVDKDDAEKEPAVYDTESSDDEFQFTGEWPPFKKVGDYDP-FCDDASLSIQKVVFD-EKSGHIVIGARGGHVLLYSIE 541

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Match: A0A553NU59 (LLGL domain-containing protein OS=Tigriopus californicus OX=6832 GN=TCAL_03771 PE=4 SV=1)

HSP 1 Score: 84.3445 bits (207), Expect = 1.236e-12
Identity = 119/487 (24.44%), Postives = 199/487 (40.86%), Query Frame = 2

Query:   62 NERKVLGKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKISHLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYK--LELDSRLFITSICECKNVVFENFSSENIPILIGCNNGAI-----EMCVVKETHVVRSNVIK--PEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLLI--FPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITN--GLKDKNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQIT---RMSNIIEVENYEISDDSGISTDDKIEK----------PYKSSQIK----LFAASYDNGSVSTWFLTPDQCFLSESVNLNKFY----NSSSTEKQEKNILWPRFQKCGIW 1420
            N+   +    + K  A+  K     V  Q G+  I  H+     +DQ   +S + F+  +G LV    +  LH W  N      T I  K    LD RL   S+  C + +       N+ +L+G   G I     E+  + E  + +  V+K  PE F +    ++ +L+  + +          ++LI +    G ++  D ++ + +  ++   Q     + +    + +Q + S  DG F I   +   + L     PYGP+PCKSI K L A  +G      VFSGGMP  +Y D  +VSV + ++    F  +  VV+F++  +         I VLT  E V I      W   +   +     S IT   ++SN+ E    ++ +       DK+            P KS++      L    +++GSV  W        L  SV  NKF+         E+ E    WP F++ G++
Sbjct:   56 NKPAAMAWDGELKLLAIATKHGALRVVGQPGVEFIGEHE-----QDQ--PVSKMIFIPGQGRLVTLTEDNFLHLWEING-----TEITEKSSTHLDGRLKRVSVM-CHDSIH------NM-VLLGTEGGNIYQLKLEIFTISENIIYQDIVMKGAPEDFKVNPGAVEGLLIQPNES---------ERILIGY--ARGLIVLWDRKSSVASQTYVTSQQLESLAWRN----DGSQFISSHNDGSFVIWSTQGNGEPLEPPNTPYGPYPCKSISKILWAHQNG--STWVVFSGGMPRASYGDKFSVSVMMGEDKHQVFDLSSKVVEFELFYDEESTNRPAGIFVLTEEELVTIDLATDSWPVFHAPYLNSIHASAITALIQVSNVSECVFTKLKEMGEAERKDKVSDREWPVNGGVVPEKSNKDASCHDLLVTGHEDGSVKLWSCGDSALALLLSVKTNKFFVGDELDEPFEEDEDEEEWPPFRRIGLY 505

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Match: A0A4U8USY0 (LLGL domain-containing protein OS=Steinernema carpocapsae OX=34508 GN=L596_003567 PE=4 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 2.050e-11
Identity = 96/446 (21.52%), Postives = 183/446 (41.03%), Query Frame = 2

Query:   80 GKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFED--QIGKISHLQFLSKKGNLVGFGGELGLHFWISN-NESNSYTYIFYKLELDSRLFITSICECKNVV-----FENFSSENIP-ILIGCNNGAI-----------EMCVVKETHVVRSNVIKPEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKD---KNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEV--------ENYEISDDSGISTDDK----------IEKPYKSSQIKLFAASYDNGSVSTW 1294
            G  S   CFAV+++L + ++ +  G + ++  ++  +     +   I+ + F+  +  L+           +SN +++ +  ++FYK E+  +    +     N +     FE   ++ I  +L+G   G +           E  +   T +   + +K E   +  + +D++                 K+ + F   +        +  +  F+  + I K+ F        EN+ +  +  DG +   +M++        P+GP+PC +I+K L    S I  +  +FSGGMP  +Y D  TVS+ I  E  + F F   VVDF V+ + L        +LVL   E V I   +  W       +FP   + IT +S + +V        E Y +   SG +T  K           E   + S  +++   +++GSV+ W
Sbjct:   32 GFPSGVSCFAVDDQLSILAIGTTTGELRLYGEENVELCGSLPEHKAITRIYFVPGQAELIA----------VSNGSDALAADHLFYKFEIVGQTLKRTDAPVHNCLKRITCFEMMDTDGITNLLLGTVTGNVFALSPKTLELDEWVIFDNTELKNVSALKEEDKSITDIFVDKLDS--------------QKISLVFNAAVIVSYNLQQDTVLFLFQAQQHISKVFF--------ENDFVYCAYGDGSYEKWNMKSGKSVESRMPFGPYPCTAIEKLLVISDSTISNEIIIFSGGMPNASYGDRFTVSL-ISAERTVVFDFGSEVVDFLVVRDTLGQNVTPTALLVLCKEELVAIDLLDPKWRPFALPYLFPLHYAPITCLSVVDDVPEHVRNNLEEYGLK-CSGQTTSRKWPIKFTFLNTTESKGRPSGTQVYLTGHEDGSVNVW 443

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Match: A0A016SJI3 (LLGL domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0219.g2450 PE=4 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 3.323e-11
Identity = 131/592 (22.13%), Postives = 234/592 (39.53%), Query Frame = 2

Query:   80 GKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKISHLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYKLE----------LDSRLF-ITSICECKNVVFENFSSENIPILIGCNNG-----AIEMCVVKETHVVRSNVIK--PEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDS-ENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIID-MEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNK-ILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEVENY------EISDD----------------SGISTDDKIEKPYKSSQIKLFAASYDNGSVSTW---FLTPDQCFLSESVNLNKFYNSSSTEKQEKNIL----------------WPRFQKCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDY 1669
            G  S+  CFA ++ L L ++ + DG I I+  +  +   +  GK    + ++K    + F   LG+   +  +     T++ + LE           ++RL  ITS C     + +        +LIG  +G      I    + E  V   ++++  PE     K  +D +L     N  L ++    ++L+ ++ +   V+ T   + +  N  + +               E +Q +++  DG +   D   A   +     +GPFPC    K   A  S   EK  +FSGGMP  +Y D   V+    D     F F   V+DF ++T G    +   LVLT  E V I   +  W      QMFP   SQIT  ++   V+ +      +IS D                + I T D+     ++++ +L+   ++NG+V  W          F+ ++ N    ++    +  EK                   WP F+K G +   F +   + SI+ +    +S H+++      +FL+ ++  V+ +M  +    + C    S  + P RN K   A   +  Y
Sbjct:   31 GFPSRVSCFAYDDVLSLLAIGNLDGDINIYGGNGFIWSAEVPGK----KGIAKSAAHMYFACGLGVLIVLCRDS----TFVRFSLEGAAVTARSVLHETRLKKITSCC-----MLQKADLREAVLLIGTVSGNVFALDINTLELSEYIVFEDSILQRIPESMRRDKYPVD-LLSVCPTNPRLILMVFDQRLLLSYDSSTNEVLGTSVFDVQCKNITWTR---------------EGSQCVVALHDGSYASCDPARATIVERPAQVFGPFPCIPTKKAFFAETSRTSEKIVLFSGGMPHASYGDRFVVTARQGDR-TCVFDFASPVIDF-LLTKGADGYHTCALVLTENELVCIDLTDRYWRIIPTEQMFPLHASQITTSAHCSHVDEHVWNKMNKISADLLRNNRKYSSSAWPLNAKIPTSDEGRIVKEATKRQLYLTGHENGTVRVWSAGHAVMHLLFVIDTRNEFAGFSDEDKDVSEKEQASCDTDTSDDEFQITGDWPPFKKVGDYDP-FCDDAGL-SIQRVAFDEKSGHIVVGGRAGHVFLYTLEE-VEREMTPQTLKIELC--EASKLSVPARNSKPLPARTKSLKY 586

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Cavefish
Match: llgl2 (LLGL scribble cell polarity complex component 2 [Source:NCBI gene;Acc:103026969])

HSP 1 Score: 53.9138 bits (128), Expect = 8.406e-7
Identity = 28/75 (37.33%), Postives = 41/75 (54.67%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKN 1036
            PYG FPCK+I K L  I +       +FSGGMP  +Y D + +SV I  +  +   F   ++DF VI +G + + 
Sbjct:  274 PYGSFPCKAISKILQ-ISTRQGPPFLIFSGGMPRASYGDRHCISV-IHSKTHVALDFTSRIIDFFVIRDGERHRG 346

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Cavefish
Match: llgl2 (LLGL scribble cell polarity complex component 2 [Source:NCBI gene;Acc:103026969])

HSP 1 Score: 53.9138 bits (128), Expect = 8.668e-7
Identity = 28/75 (37.33%), Postives = 41/75 (54.67%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKN 1036
            PYG FPCK+I K L  I +       +FSGGMP  +Y D + +SV I  +  +   F   ++DF VI +G + + 
Sbjct:  274 PYGSFPCKAISKILQ-ISTRQGPPFLIFSGGMPRASYGDRHCISV-IHSKTHVALDFTSRIIDFFVIRDGERHRG 346

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Nematostella
Match: EDO48036 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKR7])

HSP 1 Score: 49.6766 bits (117), Expect = 7.035e-6
Identity = 56/236 (23.73%), Postives = 102/236 (43.22%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDF----KVITNG-LKDKNKILVLTTTECVVISRDNGVWNSHNKGQMFP-FSKSQITRMSNIIEVENY-------EISDDSGISTDDKIEKPY--------------KSSQIK-LFAASYDNGSVSTWFLTPDQCFLSESVNLNKF-------YNSSSTEKQEKNILWPRFQKCG 1414
            P+GPFPCK+I K          +    F+GGMP  +Y D N +S+      ++ F F   V+DF     + T G L +   + VL   E VVI       +   K Q +P F K  +T + +     +Y       ++ +    +  D+I+  Y              + ++ K +    +++GSV  W ++  +  L  +++ +K        +++ + E +E+   WP F+K G
Sbjct:  272 PFGPFPCKAITKIE------WHDNSVFFAGGMPRASYGDKNCISLVQGSTTQVVFDFTSRVIDFITVIPLTTVGFLAEPACLAVLCEQELVVI-------DLKTKEQGYPTFMKPYLTCLHSSPITTSYHCHGCPSQLWNQICAAGKDQIQSEYSHESWPITGGKTLVEDAETKDILITGHEDGSVQFWDVSQVEMQLMYTLSTSKMFISDHEGHDNGTQEVEEEG--WPPFKKVG 492

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
Match: llgl2 (LLGL scribble cell polarity complex component 2 [Source:NCBI gene;Acc:101172480])

HSP 1 Score: 52.7582 bits (125), Expect = 2.247e-6
Identity = 71/352 (20.17%), Postives = 127/352 (36.08%), Query Frame = 2

Query:   80 GKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDT--LIFEDQIGKISHLQFLSKKGNLVGFGGELGLHFWISNN--------ESNSYTYIFYKLELDSRLFITSICECKNVVFENFSSENIPILIGCNNGAIEM-----------CVVKETHVVRSNVIKPEKFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVEN-------NQILISTFDGKF-----GIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKN 1036
            G   Q         L+L ++ ++ G I ++       +   D+   ++ + FL  +  LV    +  LH W            E   +        L S   IT++    +       +E   + +    G  E+             V + ++ R N+   E         +++++     G+L +  L    L++  C    V    S   I+  +    +Q  E    + + +E+         IL S  DG +     G  D      D    PYG FPCK+I K +  + +       +FSGGMP  +Y D + ++V I  +  +   F   ++DF VI  G   K 
Sbjct:   50 GFPHQPSALGHSSSLQLLAIGTRSGAIKLYGAPGVEFMGLHDENAAVTQVHFLPHQVELVTLLDDNSLHMWTLKGHKGVSELLEIGRFVLTGPPGALPSVTRITAVLAHSSGELLLLGTEGGHVFVVEVPGFRELEERNISLEQVTSRVPDNYIGRRNLEHVEALQENPADANQVVIG-YGRGVLVVWDLKKHSLLQCICP-SQVRCPSSMGMILRMQLKGFMQSNEAPLLYFQALESVWWTEDGGCILSSHTDGSYCRWTVGETDGNEEKSDT---PYGTFPCKAISKIMQ-LPTAEGPPFLLFSGGMPRASYGDRHCITV-IHGKSHVALDFTSRIIDFFVIREGPHHKG 394

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
Match: LLGL1 (LLGL scribble cell polarity complex component 1 [Source:NCBI gene;Acc:101167542])

HSP 1 Score: 51.9878 bits (123), Expect = 3.232e-6
Identity = 26/74 (35.14%), Postives = 41/74 (55.41%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDK 1033
            PYGPFPCK+I K L    + +     ++SGGMP  +Y D + +++  +D+  +   F   V+DF  + N   DK
Sbjct:  288 PYGPFPCKAITKILWRT-TQLSSPVILYSGGMPRASYGDRHCLTIQ-QDKEHVTLDFTSRVIDFFTVHNMDNDK 359

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
Match: LLGL1 (LLGL scribble cell polarity complex component 1 [Source:NCBI gene;Acc:101167542])

HSP 1 Score: 51.9878 bits (123), Expect = 3.654e-6
Identity = 26/74 (35.14%), Postives = 40/74 (54.05%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDK 1033
            PYGPFPCK+I K L   +        ++SGGMP  +Y D + +++  +D+  +   F   V+DF  + N   DK
Sbjct:  288 PYGPFPCKAITKIL---WRTTHSPVILYSGGMPRASYGDRHCLTIQ-QDKEHVTLDFTSRVIDFFTVHNMDNDK 357

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
Match: llgl2 (LLGL scribble cell polarity complex component 2 [Source:NCBI gene;Acc:101172480])

HSP 1 Score: 50.8322 bits (120), Expect = 9.315e-6
Identity = 26/75 (34.67%), Postives = 39/75 (52.00%), Query Frame = 2

Query:  812 PYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKN 1036
            PYG FPCK+I K +  + +       +FSGGMP  +Y D + ++V I  +  +   F   ++DF VI  G   K 
Sbjct:  292 PYGTFPCKAISKIMQ-LPTAEGPPFLLFSGGMPRASYGDRHCITV-IHGKSHVALDFTSRIIDFFVIREGPHHKG 364

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST
Match: SMESG000039127.1 (SMESG000039127.1)

HSP 1 Score: 1581.62 bits (4094), Expect = 0.000e+0
Identity = 793/799 (99.25%), Postives = 799/799 (100.00%), Query Frame = 2

Query:  527 KIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKDYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSNMTILQLSLPDLCALKTFNINMGILNFXXXXXXXXXXXXAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMSLNSLLM 2923
            KIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKI+QKIEFDFSHIEL+ENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQ+FPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLI+DSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEK+YRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLS+MTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMSLNSLLM
Sbjct:   23 KIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKILQKIEFDFSHIELLENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQIFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIYDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKEYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSHMTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMSLNSLLM 821

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST
Match: SMESG000039127.1 (SMESG000039127.1)

HSP 1 Score: 1574.3 bits (4075), Expect = 0.000e+0
Identity = 790/804 (98.26%), Postives = 799/804 (99.38%), Query Frame = 2

Query:  512 DLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKDYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSNMTILQLSLPDLCALKTFNINMGILNFXXXXXXXXXXXXAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMSLNSLLM 2923
            ++ +LKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKI+QKIEFDFSHIEL+ENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQ+FPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLI+DSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEK+YRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLS+MTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNE    MKNAVIPIDFMKEAKMSLNSLLM
Sbjct:   45 EVQELKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKILQKIEFDFSHIELLENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQIFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIYDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKEYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSHMTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNE----MKNAVIPIDFMKEAKMSLNSLLM 844

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST
Match: SMESG000039127.1 (SMESG000039127.1)

HSP 1 Score: 1570.44 bits (4065), Expect = 0.000e+0
Identity = 789/800 (98.62%), Postives = 796/800 (99.50%), Query Frame = 2

Query:  524 LKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQMFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKDYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSNMTILQLSLPDLCALKTFNINMGILNFXXXXXXXXXXXXAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMSLNSLLM 2923
            +KIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKI+QKIEFDFSHIEL+ENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQ+FPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLI+DSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEK+YRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLS+MTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNE    MKNAVIPIDFMKEAKMSLNSLLM
Sbjct:   13 VKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENEIINFEFLKILQKIEFDFSHIELLENNQILISTFDGKFGIIDMEAFNKDLLIFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIEDEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSHNKGQIFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKLFAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQKCGIWKSMFAESISIESIKLIYDSNESIHLLICTNRKSLFLFKVDPIVDGKMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDEFDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAGQPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNNENKFELFLGFTNGSIIGINFLVDKNSEFCIEKEYRKLFTNTNQEIINLYVFETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFNDNMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRFKFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFLFLSHMTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSSQLNILGNRKYKICKLIAEIKANQEENCNE----MKNAVIPIDFMKEAKMSLNSLLM 808

[Close]

BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST
Match: SMESG000039124.1 (SMESG000039124.1)

HSP 1 Score: 317.775 bits (813), Expect = 1.535e-102
Identity = 155/157 (98.73%), Postives = 156/157 (99.36%), Query Frame = 2

Query:   56 MENERKVLGKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKISHLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYKLELDSRLFITSICECKNVVFENFSSENIPILIGCNNGAIEMCVVKETHVVRSNVIKPEKFDLPKL 526
            MENERKVLGKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKISHLQFLSKKGNLVGFGGELGLH WISNNESNSYTYIFYKLELDSRLFITSICECKNVVFENFSSENIPILIGCNNGAIEMCVVKETHVVR+NVIKPEKFDLPKL
Sbjct:    1 MENERKVLGKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQIGKISHLQFLSKKGNLVGFGGELGLHLWISNNESNSYTYIFYKLELDSRLFITSICECKNVVFENFSSENIPILIGCNNGAIEMCVVKETHVVRTNVIKPEKFDLPKL 157

The following BLAST results are available for this feature:

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Celegans
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Zebrafish
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Xenopus
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Cavefish
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Sea Lamprey
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Yeast
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Nematostella
BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
LLGL2	1.397e-9	29.44	LLGL scribble cell polarity complex component 2 [S...	[more]
LLGL2	1.716e-9	29.44	LLGL scribble cell polarity complex component 2 [S...	[more]
LLGL2	1.775e-9	29.44	LLGL scribble cell polarity complex component 2 [S...	[more]
LLGL2	8.078e-8	31.08	LLGL scribble cell polarity complex component 2 [S...	[more]
LLGL2	8.078e-8	31.08	LLGL scribble cell polarity complex component 2 [S...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
l(2)gl	4.526e-8	37.93	gene:FBgn0002121 transcript:FBtr0078169	[more]
l(2)gl	4.526e-8	37.93	gene:FBgn0002121 transcript:FBtr0078167	[more]
l(2)gl	4.526e-8	37.93	gene:FBgn0002121 transcript:FBtr0078168	[more]
l(2)gl	4.734e-8	37.93	gene:FBgn0002121 transcript:FBtr0306592	[more]
l(2)gl	4.734e-8	37.93	gene:FBgn0002121 transcript:FBtr0306590	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
llgl1	1.243e-6	27.35	LLGL scribble cell polarity complex component 1 [S...	[more]
llgl1	1.245e-6	27.23	LLGL scribble cell polarity complex component 1 [S...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Llgl2	1.422e-7	33.66	LLGL2 scribble cell polarity complex component [So...	[more]
Llgl2	1.455e-7	33.66	LLGL2 scribble cell polarity complex component [So...	[more]
Llgl1	1.407e-6	34.34	LLGL1 scribble cell polarity complex component [So...	[more]
Llgl1	1.484e-6	34.34	LLGL1 scribble cell polarity complex component [So...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5RCX2\|L2GL2_PONAB	1.228e-9	31.11	LLGL scribble cell polarity complex component 2 OS...	[more]
sp\|Q6P1M3\|L2GL2_HUMAN	8.242e-9	29.44	LLGL scribble cell polarity complex component 2 OS...	[more]
sp\|Q08470\|L2GL_DROPS	7.668e-8	34.58	Protein lethal(2) giant larvae OS=Drosophila pseud...	[more]
sp\|P08111\|L2GL_DROME	4.745e-7	37.93	Lethal(2) giant larvae protein OS=Drosophila melan...	[more]
sp\|Q3TJ91\|L2GL2_MOUSE	9.944e-7	33.66	LLGL scribble cell polarity complex component 2 OS...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A433UAG8	3.945e-15	26.72	WD_REPEATS_REGION domain-containing protein OS=Ely...	[more]
A0A158PLD8	2.875e-13	22.88	LLGL domain-containing protein OS=Angiostrongylus ...	[more]
A0A553NU59	1.236e-12	24.44	LLGL domain-containing protein OS=Tigriopus califo...	[more]
A0A4U8USY0	2.050e-11	21.52	LLGL domain-containing protein OS=Steinernema carp...	[more]
A0A016SJI3	3.323e-11	22.13	LLGL domain-containing protein OS=Ancylostoma ceyl...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
llgl2	8.406e-7	37.33	LLGL scribble cell polarity complex component 2 [S...	[more]
llgl2	8.668e-7	37.33	LLGL scribble cell polarity complex component 2 [S...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO48036	7.035e-6	23.73	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
llgl2	2.247e-6	20.17	LLGL scribble cell polarity complex component 2 [S...	[more]
LLGL1	3.232e-6	35.14	LLGL scribble cell polarity complex component 1 [S...	[more]
LLGL1	3.654e-6	35.14	LLGL scribble cell polarity complex component 1 [S...	[more]
llgl2	9.315e-6	34.67	LLGL scribble cell polarity complex component 2 [S...	[more]

BLAST of Lethal(2) giant larvae-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000039127.1	0.000e+0	99.25	SMESG000039127.1	[more]
SMESG000039127.1	0.000e+0	98.26	SMESG000039127.1	[more]
SMESG000039127.1	0.000e+0	98.63	SMESG000039127.1	[more]
SMESG000039124.1	1.535e-102	98.73	SMESG000039124.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30000608 ID=SMED30000608|Name=Lethal(2) giant larvae-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3037bp
TTTGTTATTTTAAAAATAGTACTAGTTGGATTTTTATTGCCTTAAGTTTA
TTAAAATGGAAAATGAGAGAAAAGTATTAGGAAAGGCCTCTCAGTGGAAA
TGTTTTGCCGTGGAAGAAAAATTGAAATTATTTTCTGTCGCTTCTCAAGA
TGGTTTAATACTAATATTTTCCCACGACGATACATTGATATTTGAGGATC
AGATTGGAAAGATCAGTCATTTACAGTTTCTTTCGAAAAAGGGTAACTTG
GTTGGCTTCGGAGGTGAATTAGGGTTACATTTTTGGATTTCGAACAATGA
ATCTAATTCGTATACATACATATTTTATAAATTAGAACTCGACTCAAGGT
TGTTTATCACTTCAATATGTGAATGTAAAAATGTCGTGTTTGAAAACTTT
TCAAGCGAAAACATCCCGATTTTGATTGGTTGTAATAATGGTGCAATAGA
AATGTGTGTCGTTAAGGAAACTCACGTGGTCAGATCCAATGTGATCAAGC
CGGAGAAATTTGATTTGCCAAAATTGAAAATTGATAGAATATTAGTGACG
AGATCTGCAAATGGAATTCTAACAATTTTGGCATTGGTCAATAAGGTTCT
CATAGAATTCGAATGCACAATTGGCAGTGTCATAGAAACTGATTCTGAGA
ATGAAATAATAAATTTTGAATTTCTCAAAATCATCCAGAAAATTGAATTC
GATTTTTCTCATATTGAACTAGTAGAAAACAATCAAATATTGATCTCCAC
ATTTGATGGAAAGTTTGGAATTATTGACATGGAGGCTTTCAATAAAGATT
TATTAATTTTTCCCTATGGTCCGTTTCCATGCAAATCTATTGACAAATGT
TTGACTGCTATATTTTCTGGAATCAAAGAAAAATGCTATGTATTTTCTGG
GGGAATGCCAGCAGTTACATATAAAGATCTAAATACTGTTTCTGTTTCCA
TTGAAGATGAACCAGAAATCTGTTTCACATTCAACGACATTGTAGTGGAT
TTCAAAGTTATTACAAATGGATTAAAAGATAAGAATAAAATTCTTGTATT
AACAACAACGGAATGCGTTGTCATTTCTCGTGATAATGGAGTTTGGAATT
CGCATAATAAAGGCCAAATGTTTCCTTTTTCTAAGAGTCAAATCACAAGA
ATGAGCAATATAATAGAAGTGGAAAATTACGAAATAAGCGACGACAGTGG
AATTTCAACTGACGACAAAATTGAAAAGCCGTATAAAAGTTCACAGATAA
AATTATTTGCTGCTTCTTACGACAACGGATCGGTATCCACTTGGTTTTTG
ACACCAGATCAATGTTTCTTAAGTGAAAGTGTTAATTTAAACAAGTTTTA
TAATTCTTCGTCAACTGAGAAACAAGAAAAAAACATACTATGGCCAAGAT
TCCAAAAATGTGGAATATGGAAATCGATGTTTGCGGAGAGTATATCAATT
GAATCAATCAAACTAATACATGATTCAAATGAATCAATTCATTTATTAAT
TTGCACCAATAGAAAATCGTTATTTTTATTCAAGGTAGATCCAATTGTGG
ACGGTAAAATGGAGAATAAAAGGTGTTATAGGCAATGGTGTCATCATCAC
ATATCTGTCAATAATGCTCCAATGAGAAATTATAAAATCAACACAGCGGC
TAACACAAATTCAGATTATCTTTATTTAATAACTTTGATTACGTTCGGTG
ATGAATTTGATTCGTTGATTGTGGATTTCAGCTTCAGGGGAAATATCTTG
AGTTTTGCTAGTAGAATCGGATTTTGTTGCGTGAATATTGCCAATGGGAA
GCACTTATTTTTGCCTTTCTCCTTATTTAAAATGGTTGATACTTTTAAAG
CTGGACAACCTTTCACAGAAAGAATACAGAGAAAAATACGAAAGAGAAAA
TCATTGGAGTATTCTATGGGGAAACTAGAATCTGAAGAAATAATAGACCT
GCGAAACTATGCTAGTTCCACGCAGCCGAAATCACTATTTCTGTGGCAGA
ATAATGAGAATAAATTTGAATTGTTTTTAGGATTTACAAATGGCTCTATT
ATTGGAATTAATTTCCTAGTGGATAAAAATTCAGAATTTTGTATTGAAAA
GGACTACAGAAAATTATTCACAAACACCAATCAAGAAATCATCAATCTTT
ACGTGTTTGAAACTCAGATTAATCCGTCTTTGATTACCGACTCGTTAAGC
CTAAGGGAAGGAATAAATCAAACCGACAATCATTCTATATCCACAAACAC
AAGTCCTGAATTGAATTCCTTGTGTGCAACGGATTGGAATAGTTCTTTTA
ATGACAATATGTCTATAAGAAGCTCAAAGTCCAAGACTTTATCATTCAAT
TGGCTTAAAGCTCGTGAATCTGAATTCAAAGAAAAAACATTATTATTAAG
AATAGATAAATATTCTATGAAAGTCATTGAAATTCAAAAAATGAAGACGA
GATTTAAATTCAAGGTCAATGAACATTATATGAAAGACTATTCGGTGATT
ACATCAAAAAGGAAAAACAAAACTCAAGATATTTCGATACCAATTATTCT
TGATTCTAGAATTAAAATTGCAGTGGAAAATCCTACGAAGTCGTTTTGCT
TTTTATTTTTATCCAATATGACTATCCTTCAATTATCATTGCCAGATCTA
TGTGCTTTAAAGACCTTTAATATTAACATGGGAATCTTGAATTTCGATCT
CGTTTCACTAGATTCAGATGTCGTTTTAGTAGCAGAAAATTTCAAATGCA
GCAGCCAGTTAAACATTTTGGGAAATCGGAAATATAAAATTTGCAAACTC
ATTGCAGAAATCAAGGCAAATCAGGAAGAAAATTGCAACGAAGTTAAAAA
TAATATGAAAAATGCAGTTATTCCAATTGATTTTATGAAAGAAGCTAAGA
TGAGTTTGAATTCATTGCTGATGTGACAAAGATTGCCGGATGTCCTTGAA
AATGAAGATATCTATATTTGAAAACTTATTTTAATTTTTTATGAAGAAAT
TTTAAAAATTGTTTTTGGATTTAAAAGTATATAAACC

protein sequence of SMED30000608-orf-1

>SMED30000608-orf-1 ID=SMED30000608-orf-1|Name=SMED30000608-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=957bp
MENERKVLGKASQWKCFAVEEKLKLFSVASQDGLILIFSHDDTLIFEDQI
GKISHLQFLSKKGNLVGFGGELGLHFWISNNESNSYTYIFYKLELDSRLF
ITSICECKNVVFENFSSENIPILIGCNNGAIEMCVVKETHVVRSNVIKPE
KFDLPKLKIDRILVTRSANGILTILALVNKVLIEFECTIGSVIETDSENE
IINFEFLKIIQKIEFDFSHIELVENNQILISTFDGKFGIIDMEAFNKDLL
IFPYGPFPCKSIDKCLTAIFSGIKEKCYVFSGGMPAVTYKDLNTVSVSIE
DEPEICFTFNDIVVDFKVITNGLKDKNKILVLTTTECVVISRDNGVWNSH
NKGQMFPFSKSQITRMSNIIEVENYEISDDSGISTDDKIEKPYKSSQIKL
FAASYDNGSVSTWFLTPDQCFLSESVNLNKFYNSSSTEKQEKNILWPRFQ
KCGIWKSMFAESISIESIKLIHDSNESIHLLICTNRKSLFLFKVDPIVDG
KMENKRCYRQWCHHHISVNNAPMRNYKINTAANTNSDYLYLITLITFGDE
FDSLIVDFSFRGNILSFASRIGFCCVNIANGKHLFLPFSLFKMVDTFKAG
QPFTERIQRKIRKRKSLEYSMGKLESEEIIDLRNYASSTQPKSLFLWQNN
ENKFELFLGFTNGSIIGINFLVDKNSEFCIEKDYRKLFTNTNQEIINLYV
FETQINPSLITDSLSLREGINQTDNHSISTNTSPELNSLCATDWNSSFND
NMSIRSSKSKTLSFNWLKARESEFKEKTLLLRIDKYSMKVIEIQKMKTRF
KFKVNEHYMKDYSVITSKRKNKTQDISIPIILDSRIKIAVENPTKSFCFL
FLSNMTILQLSLPDLCALKTFNINMGILNFDLVSLDSDVVLVAENFKCSS
QLNILGNRKYKICKLIAEIKANQEENCNEVKNNMKNAVIPIDFMKEAKMS
LNSLLM*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003779	actin binding

Vocabulary: **cellular component**
Term	Definition
GO:0005856	cytoskeleton
GO:0016459	myosin complex
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005886	plasma membrane
GO:0016020	membrane

Vocabulary: **biological process**
Term	Definition
GO:0007605	sensory perception of sound
GO:0006887	exocytosis
GO:0007049	cell cycle

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0003117	parapharyngeal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR013577	LLGL2

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR013577	Lethal giant larvae homologue 2	PFAM	PF08366	LLGL	coord: 252..340 e-value: 6.7E-14 score: 52.1
None	No IPR available	PANTHER	PTHR10241:SF29	LETHAL(2) GIANT LARVAE PROTEIN	coord: 15..373
None	No IPR available	PANTHER	PTHR10241	LETHAL 2 GIANT LARVAE PROTEIN	coord: 15..373

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Lethal(2) giant larvae-like protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

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