Polycomb protein suz12

Overview
NamePolycomb protein suz12
Smed IDSMED30000594
Length (bp)2402
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Polycomb protein suz12 (SMED30000594) t-SNE clustered cells

Violin plots show distribution of expression levels for Polycomb protein suz12 (SMED30000594) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Polycomb protein suz12 (SMED30000594) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Polycomb protein suz12 (SMED30000594) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000594

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30000594h1SMcG0004368 SmedASXL_016129SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30000594h1SMcG0004368 dd_Smed_v4_12930_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000594h1SMcG0004368 dd_Smed_v4_12930_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30000594h1SMcG0004368 dd_Smed_v4_12930_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Human
Match: SUZ12 (SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101])

HSP 1 Score: 116.316 bits (290), Expect = 4.301e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++++DSE E + +WL+     +IEEF+DVN GEK++M+LWN H++ H +  D
Sbjct:  430 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIAD 629
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Human
Match: SUZ12 (SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101])

HSP 1 Score: 116.316 bits (290), Expect = 4.530e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++++DSE E + +WL+     +IEEF+DVN GEK++M+LWN H++ H +  D
Sbjct:  407 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIAD 606
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Fly
Match: Su(z)12 (gene:FBgn0020887 transcript:FBtr0074916)

HSP 1 Score: 125.176 bits (313), Expect = 4.364e-29
Identity = 80/237 (33.76%), Postives = 116/237 (48.95%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTR-SQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIE------IGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            VY F ++N+  Q T  +Q + CPWC   C      L    L+KHL+  HARF F Y        S   I+V +N+ YDGS         G   S   R    P R+   T ++ C       P  +   +D             R  + GHNR Y+++ T +     +LD+DSE E +  WL+    + I+EF+DVN GEK++M+LWN H++ H + GD  +PI  + F+  KGTEI
Sbjct:  392 VYNFMYSNNTRQQTEYTQELNCPWCGLDC------LRLYALLKHLKLCHARFNFTY----QPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTC-GPVRRTSVTSLMVC------RPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEI 611
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Fly
Match: Su(z)12 (gene:FBgn0020887 transcript:FBtr0074917)

HSP 1 Score: 125.176 bits (313), Expect = 4.455e-29
Identity = 80/237 (33.76%), Postives = 116/237 (48.95%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTR-SQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIE------IGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            VY F ++N+  Q T  +Q + CPWC   C      L    L+KHL+  HARF F Y        S   I+V +N+ YDGS         G   S   R    P R+   T ++ C       P  +   +D             R  + GHNR Y+++ T +     +LD+DSE E +  WL+    + I+EF+DVN GEK++M+LWN H++ H + GD  +PI  + F+  KGTEI
Sbjct:  392 VYNFMYSNNTRQQTEYTQELNCPWCGLDC------LRLYALLKHLKLCHARFNFTY----QPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTC-GPVRRTSVTSLMVC------RPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEI 611
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Zebrafish
Match: suz12a (SUZ12 polycomb repressive complex 2 subunit a [Source:NCBI gene;Acc:794171])

HSP 1 Score: 119.398 bits (298), Expect = 2.493e-27
Identity = 78/233 (33.48%), Postives = 113/233 (48.50%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGT 1810
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I  +         P ++ P T I+ C       P    PS+              R  + GHNR Y++S +       ++++DSE E + DWL+     +IEEFTDVN GEK+IM+LWN  ++ H +  D  +     SF+ Q GT
Sbjct:  395 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDILCQPGFAFSRNGPVKRTPVTQILVC------RPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEMEVDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHGFIADNQMNQACMSFVEQHGT 610
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 117.472 bits (293), Expect = 1.115e-26
Identity = 73/217 (33.64%), Postives = 109/217 (50.23%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WLQ     +IEEFTDVN GEK++M+LWN H++ + +  D
Sbjct:  390 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNGFIAD 589
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 114.005 bits (284), Expect = 1.301e-25
Identity = 72/208 (34.62%), Postives = 104/208 (50.00%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSH 1735
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WLQ     +IEEFTDVN GEK++M+LWN H
Sbjct:  390 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLH 580
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Zebrafish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit b [Source:NCBI gene;Acc:561871])

HSP 1 Score: 114.005 bits (284), Expect = 1.306e-25
Identity = 72/208 (34.62%), Postives = 104/208 (50.00%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSH 1735
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WLQ     +IEEFTDVN GEK++M+LWN H
Sbjct:  391 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLH 581
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 117.087 bits (292), Expect = 1.543e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  345 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 544
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 117.087 bits (292), Expect = 1.686e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  350 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 549
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 117.472 bits (293), Expect = 1.914e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  428 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 627
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 117.087 bits (292), Expect = 1.931e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRL-----LEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  355 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 554
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Match: suz12 (SUZ12, polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:779745])

HSP 1 Score: 117.087 bits (292), Expect = 1.957e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRL-----LEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  384 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 583
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Mouse
Match: Suz12 (SUZ12 polycomb repressive complex 2 subunit [Source:MGI Symbol;Acc:MGI:1261758])

HSP 1 Score: 116.316 bits (290), Expect = 2.866e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++++DSE E + +WL+     +IEEF+DVN GEK++M+LWN H++ H +  D
Sbjct:  432 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIAD 631
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Mouse
Match: Suz12 (SUZ12 polycomb repressive complex 2 subunit [Source:MGI Symbol;Acc:MGI:1261758])

HSP 1 Score: 116.316 bits (290), Expect = 2.942e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++++DSE E + +WL+     +IEEF+DVN GEK++M+LWN H++ H +  D
Sbjct:  409 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIAD 608
[Close]
BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Match: sp|Q9NJG9|SUZ12_DROME (Polycomb protein Su(z)12 OS=Drosophila melanogaster OX=7227 GN=Su(z)12 PE=1 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 4.466e-28
Identity = 80/237 (33.76%), Postives = 116/237 (48.95%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTR-SQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIE------IGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            VY F ++N+  Q T  +Q + CPWC   C      L    L+KHL+  HARF F Y        S   I+V +N+ YDGS         G   S   R    P R+   T ++ C       P  +   +D             R  + GHNR Y+++ T +     +LD+DSE E +  WL+    + I+EF+DVN GEK++M+LWN H++ H + GD  +PI  + F+  KGTEI
Sbjct:  392 VYNFMYSNNTRQQTEYTQELNCPWCGLDC------LRLYALLKHLKLCHARFNFTY----QPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTC-GPVRRTSVTSLMVC------RPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEI 611
[Close]
BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Match: sp|Q6DC03|SZ12A_DANRE (Polycomb protein suz12-A OS=Danio rerio OX=7955 GN=suz12a PE=2 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 2.037e-26
Identity = 78/233 (33.48%), Postives = 113/233 (48.50%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGT 1810
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I  +         P ++ P T I+ C       P    PS+              R  + GHNR Y++S +       ++++DSE E + DWL+     +IEEFTDVN GEK+IM+LWN  ++ H +  D  +     SF+ Q GT
Sbjct:  395 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDILCQPGFAFSRNGPVKRTPVTQILVC------RPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEMEVDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHGFIADNQMNQACMSFVEQHGT 610
[Close]
BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Match: sp|B0R1D5|SZ12B_DANRE (Polycomb protein suz12-B OS=Danio rerio OX=7955 GN=suz12b PE=2 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 8.414e-26
Identity = 73/217 (33.64%), Postives = 109/217 (50.23%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WLQ     +IEEFTDVN GEK++M+LWN H++ + +  D
Sbjct:  390 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNGFIAD 589
[Close]
BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Match: sp|Q0VA03|SUZ12_XENTR (Polycomb protein suz12 OS=Xenopus tropicalis OX=8364 GN=suz12 PE=2 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 9.096e-26
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++D+DSE E + +WL+     +IEEF+DVN GEK++M++WN H++ H +  D
Sbjct:  387 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIAD 586
[Close]
BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Match: sp|Q80U70|SUZ12_MOUSE (Polycomb protein Suz12 OS=Mus musculus OX=10090 GN=Suz12 PE=1 SV=2)

HSP 1 Score: 116.316 bits (290), Expect = 2.005e-25
Identity = 71/211 (33.65%), Postives = 105/211 (49.76%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYC------FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS   G    I  +         P ++ P THI+ C        M +            R    GHNR Y++S T +     ++++DSE E + +WL+     +IEEF+DVN GEK++M+LWN H++ H +  D
Sbjct:  432 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLCHSRFIFNYVYHPK----GARIDVSINECYDGSY-AGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIAD 631
[Close]
BLAST of Polycomb protein suz12 vs. TrEMBL
Match: A0A481NWA7 (Polycomb protein SUZ12-2 OS=Dugesia japonica OX=6161 GN=suz12-2 PE=2 SV=1)

HSP 1 Score: 936.021 bits (2418), Expect = 0.000e+0
Identity = 492/607 (81.05%), Postives = 554/607 (91.27%), Query Frame = 2 
Query:  107 MDYLRNGNCCQQRPEDLNYEYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFXXXXXXXXXXCERLVKIRIPRVRSSVDTNHFSTIKDINWNLIFIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPXXXXXXXXXXXXVFDNVTDSPERIWVREVSPTNSVAKEYDKWPRILFKLESSNFQSKLETNHVDFKSHILNGXXXXXXXXXXXXXXXXXXVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEIKXXXXXXXXXXXXXXXXXXXXXSQKQLIEVIGLLDQM 1927
            M+YLRNGNCCQQ+ ++LNYEYEEIIKRLG+I+SLYGYLKINFKRSHFLLFRNLSYIQG++NS K+K K +DKICERL+K+RIPRVRS  D++ FS +K++NWNLIF+GFFDS HESQWETI+A ADIYVIHHWKNSRKFQSGK T KFLSNL I CNGRP ++D +FQK HEF QSQLF DT+HLR+VYSYLLFKLRV ERRT D SKI++N Q+N NNG YAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPTESL+  T +E V +N +DSPERIWVREVSP++SVAKEYDKWPRILF+LESSN  +KL+TN VD K +I NGV+DK+ KK +K KL+VN+VYKF+HNNH+LQW+RSQSVKCPWCNFICEK+  KLSF+CL+KHLQTFHARFTFK++ I   NISS+IIEVRLNECYDGSIEIGLRSS+E+R LEKPERKLPFTHI+YC QMCKINPMV NPSIDLRP+VWGHNRKY+YSTTGI+K IGDLD+DSE EDNLDWLQ MYFKRIEEFTDVNPGEK+IMQLWNSHLLDHKYNGDFMVPILTKSFI+QKG EIKEHNLRNNLLLHLVNLVEFG+LSQKQLIEVIG+LDQM
Sbjct:    1 MEYLRNGNCCQQKSDELNYEYEEIIKRLGYITSLYGYLKINFKRSHFLLFRNLSYIQGDRNSVKRKFKNLDKICERLIKVRIPRVRSLCDSSQFSVLKEVNWNLIFVGFFDSSHESQWETIHAYADIYVIHHWKNSRKFQSGKKTTKFLSNLLINCNGRP-LEDGKFQKIHEFSQSQLFHDTSHLRIVYSYLLFKLRVLERRTVDYSKIESNLQINQNNGLYAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPTESLADFTNNEMVIENFSDSPERIWVREVSPSSSVAKEYDKWPRILFRLESSNSLTKLDTNSVDIKPYISNGVIDKVSKKARKAKLEVNIVYKFYHNNHMLQWSRSQSVKCPWCNFICEKSNAKLSFSCLVKHLQTFHARFTFKHWVISETNISSMIIEVRLNECYDGSIEIGLRSSMESRSLEKPERKLPFTHIVYCSQMCKINPMVNNPSIDLRPLVWGHNRKYFYSTTGIVKCIGDLDVDSEAEDNLDWLQQMYFKRIEEFTDVNPGEKRIMQLWNSHLLDHKYNGDFMVPILTKSFIIQKGAEIKEHNLRNNLLLHLVNLVEFGVLSQKQLIEVIGILDQM 606
[Close]
BLAST of Polycomb protein suz12 vs. TrEMBL
Match: A0A267F4W9 (VEFS-Box domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig027011g2 PE=4 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 2.686e-33
Identity = 117/431 (27.15%), Postives = 177/431 (41.07%), Query Frame = 2 
Query:  641 FQDTNHLRVVYSYLLFKLRVFERR-------TADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDN--------DLKFYLLPGEYEMRLE-VSLDQPXXXXXXXXXXXXVFDNVTDSPERI--W-VREVSPTNSVAKEYDKWPRILFKLE------------------SSNFQSKLETNHVDFKSHILNGXXXXXXXXXXXXXXXXXXVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFG-IPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEK---PERKLPFTHIIYC-FQMCKIN-PMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLL---DHKYNGDFMVPILTKSFI 1795
             +D    R+V SYLL ++   E+R       +  GS+      V      Y V Y    P +               D    L  GEYE RLE +  ++P              D V+ S   +  W    + P ++ A EY++WP + F                      +  Q+K E      +    +G   +          D  V+Y F+H     Q T    ++CPWC+  C +       N L+ HL+  H+R  F       +V    +++EVR+N  Y+G  E        +   E    P R+LPFTH+I+     C     +V NP    RP+V GH R+Y++S T +     ++D DSE E   DWL+  Y + +E+FTDVN GEK +M  WN H++        G   +P L  +FI
Sbjct:  232 LRDPQANRIVQSYLLLRVSAMEKRNYSKMYDSPPGSRKSHKKDVTE----YPVQYCALLPLFNHGRAQTCTSSGTAIDCPLQLYTGEYECRLECLGAEEPA-------------DLVSASARVLQEWHGSRIRPASAEASEYERWPVVRFSARWYGVTGEPAGAEALQQPPQAEAQAKEEQPQQKSRKRQHSGTAKQSAGSKSGAGGDWRVIYNFYHAGRCRQCTEVDGLRCPWCDLDCRQA------NGLLCHLRACHSRLAFASISETSAVKRRRLLLEVRINSDYNGGYEGDPACLFRSTGFEPTPFPARRLPFTHLIHWRGAACSAQQTLVANP----RPLVSGHTRQYFHSQTCVPLLPQEIDADSEDEIAPDWLRQKYSRNLEDFTDVNEGEKAVMMAWNLHVMTWEGGPVTGQHQLPQLCSTFI 635
[Close]
BLAST of Polycomb protein suz12 vs. TrEMBL
Match: A0A267G2X8 (VEFS-Box domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig031225g1 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 4.722e-33
Identity = 116/427 (27.17%), Postives = 175/427 (40.98%), Query Frame = 2 
Query:  641 FQDTNHLRVVYSYLLFKLRVFERRTAD---GSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDN--------DLKFYLLPGEYEMRLE-VSLDQPXXXXXXXXXXXXVFDNVTDSPERI--W-VREVSPTNSVAKEYDKWPRILFKLE------------------SSNFQSKLETNHVDFKSHILNGXXXXXXXXXXXXXXXXXXVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFG-IPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEK---PERKLPFTHIIYC-FQMCKIN-PMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLL---DHKYNGDFMVPILTKSFI 1795
             +D    R+V SYLL ++   E+R       S   A      +   Y V Y    P +               D    L  GEYE RLE +  ++P              D V+ S   +  W    + P ++ A EY++WP + F                      +  Q+K E      +    +G   +          D  V+Y F+H     Q T    ++CPWC+  C +       N L+ HL+  H+R  F       +V    +++EVR+N  Y+G  E        +   E    P R+LPFTH+I+     C     +V NP    RP+V GH R+Y++S T +     ++D DSE E   DWL+  Y + +E+FTDVN GEK +M  WN H++        G   +P L  +FI
Sbjct:  230 LRDPQANRIVQSYLLLRVSAMEKRNYSKMYDSPPGARKSHKKDVTEYPVQYCAVLPLFNHGRAQTCTSSGTAIDCPLQLYTGEYECRLECLGAEEPA-------------DLVSASARVLQEWHGSRIRPASAEASEYERWPVVRFSARWTGVTGEPAGAEALQQPPQAEAQAKEEQLQQKSRKRQHSGTAKQSAGSKSGAGGDWRVIYNFYHAGRCRQCTEVDGLRCPWCDLDCRQA------NGLLCHLRACHSRLAFASISETSAVKRRRLLLEVRINSDYNGGYEGDPACLFRSTGFEPTPFPARRLPFTHLIHWRGAACSAQQTLVANP----RPLVSGHTRQYFHSQTCVPLLPQEIDADSEDEIAPDWLRQKYSRNLEDFTDVNEGEKAVMMAWNLHVMTWEGGPVTGQHQLPQLCSTFI 633
[Close]
BLAST of Polycomb protein suz12 vs. TrEMBL
Match: A0A4E0RKT3 (VEFS-Box domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_000775 PE=4 SV=1)

HSP 1 Score: 143.665 bits (361), Expect = 2.498e-31
Identity = 83/235 (35.32%), Postives = 119/235 (50.64%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLR--------------------------------SSIENRLL---------EKPERKLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLD 1744
             Y+F +  HL QW+ S+++ CPWC   C +  ++     L+ HL++ H RF FK F  PS   + + +EV LNE YDGS + GLR                                 S  +R L          +P R+LP+TH+I+     +      +P++ +RP+  GHNR YY++ +       + D+DSE ED   WL   Y +++EEFTDVN GEKQIMQLWNS LL 
Sbjct:  729 AYRFLYMGHLQQWSESKNLVCPWCQLNCGRARSR-GLEALLIHLRSTHPRFRFKAFWGPSR--AHLSLEVSLNEAYDGSNDCGLRRWTAEDGYSGHAVMAPGQLLGGWTGLGLTSDRESNASRSLTLAGCASRVSRPIRRLPYTHLIFWRGAERSVNQALDPTLSVRPMAVGHNRVYYHTRSIQPIRACEFDVDSEAEDAPVWLCQHYQRKVEEFTDVNQGEKQIMQLWNSLLLS 960
[Close]
BLAST of Polycomb protein suz12 vs. TrEMBL
Match: A0A088A7L1 (VEFS-Box domain-containing protein OS=Apis mellifera OX=7460 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 3.117e-31
Identity = 82/236 (34.75%), Postives = 123/236 (52.12%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTRS-QSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIG---LRSSIENRLLEK--PERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            VY+F +NN+  Q T + + + CPWC+  C K         L+KHL+  H+RFTF Y  IP        I+V +NECYDGS       L S   N    +  P R+   T+I+ C       P    PS+              RP + GHNR Y+++ T +     ++D+DSE E++  WLQ      I++FTDVN GEK++M++WN H++ + Y GD  +P+  + F+  KG E+
Sbjct:   18 VYQFLYNNNSRQQTEACEDLHCPWCSLDCGK------LYSLLKHLKLCHSRFTFTYVPIPQ----GARIDVAINECYDGSYAGSPHELISQPSNVAFSRTGPTRRTSVTNILVC------RPKRTKPSLSEFLELDENEYESQRPYITGHNRLYHHTVTCLPIYPKEMDIDSEGENDPKWLQTKTRMMIDDFTDVNEGEKELMKMWNLHVMKYGYVGDCQIPLACQMFLETKGKEL 237
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Cavefish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:103037652])

HSP 1 Score: 117.857 bits (294), Expect = 7.031e-27
Identity = 73/217 (33.64%), Postives = 109/217 (50.23%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     +++MDSE E + +WL+     +IEEFTDVN GEK++M+LWN H++ + +  D
Sbjct:  410 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEMDSEDERDPEWLREKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNGFIAD 609
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Cavefish
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:103037652])

HSP 1 Score: 117.087 bits (292), Expect = 1.087e-26
Identity = 73/217 (33.64%), Postives = 109/217 (50.23%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+ C       P    PS+              R  V GHNR Y++S + +     +++MDSE E + +WL+     +IEEFTDVN GEK++M+LWN H++ + +  D
Sbjct:  383 YQFLYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVC------RPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEMDSEDERDPEWLREKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNGFIAD 582
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Cavefish
Match: suz12a (polycomb protein suz12-A-like [Source:NCBI gene;Acc:103046942])

HSP 1 Score: 113.235 bits (282), Expect = 1.438e-25
Identity = 72/235 (30.64%), Postives = 115/235 (48.94%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            Y+F +NN+  Q T ++  + CPWC   C +         L+KHL+  H+RF F Y   P        I+V +N+CYDGS  +G    I  +         P ++   +H++ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + DWL+     +IEEFTDVN GEK++M++WN H++ H +  D  +      F+ + G+ I
Sbjct:  391 YQFLYNNNTRQQTEARDDLHCPWCTLNCRR------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSVNDCYDGSY-VGNPQDIHCQPGFAFSRNGPVKRTSVSHVLVC------RPKHPKPSLSEFLESEEGQLEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPDWLREKTTMQIEEFTDVNEGEKEVMKMWNLHVMKHGFIADNQMNQACMLFVEKCGSTI 608
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Cavefish
Match: suz12a (polycomb protein suz12-A-like [Source:NCBI gene;Acc:103046942])

HSP 1 Score: 113.235 bits (282), Expect = 1.691e-25
Identity = 72/235 (30.64%), Postives = 115/235 (48.94%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            Y+F +NN+  Q T ++  + CPWC   C +         L+KHL+  H+RF F Y   P        I+V +N+CYDGS  +G    I  +         P ++   +H++ C       P    PS+              R  V GHNR Y++S + +     ++++DSE E + DWL+     +IEEFTDVN GEK++M++WN H++ H +  D  +      F+ + G+ I
Sbjct:  391 YQFLYNNNTRQQTEARDDLHCPWCTLNCRR------LYSLLKHLKLSHSRFIFNYVPHPK----GARIDVSVNDCYDGSY-VGNPQDIHCQPGFAFSRNGPVKRTSVSHVLVC------RPKHPKPSLSEFLESEEGQLEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPDWLREKTTMQIEEFTDVNEGEKEVMKMWNLHVMKHGFIADNQMNQACMLFVEKCGSTI 608
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Sea Lamprey
Match: suz12a (SUZ12 polycomb repressive complex 2 subunit a [Source:NCBI gene;Acc:794171])

HSP 1 Score: 115.161 bits (287), Expect = 7.839e-27
Identity = 71/212 (33.49%), Postives = 106/212 (50.00%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRL-----LEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDH 1747
            Y+F +NN+L Q T ++  V CPWC   C K         L+KHL+  H RF F Y  +         I+V +NECYDGS   G    I ++         P ++ P T+I+ C       P    PS+              RP V GH+R Y++  T +     ++D DSE E++ +WL+     +I+EF DVN GEK++M++WN H++ H
Sbjct:  361 YQFLYNNNLRQQTEARDDVHCPWCTLNCGK------LYSLLKHLKLCHGRFIFNYVPL----TKGARIDVSVNECYDGSY-AGNPQDIHSQPGFAFSRNGPVKRTPVTYILVC------RPKRPKPSLSEFLESDELEVEQQRPYVSGHDRLYFHKDTCLPLRPQEMDEDSEDENDPEWLREKTVLQIDEFMDVNEGEKELMKMWNLHVMKH 555
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Nematostella
Match: EDO42650 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0W2])

HSP 1 Score: 109.383 bits (272), Expect = 9.070e-25
Identity = 72/218 (33.03%), Postives = 117/218 (53.67%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQ-SVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRL-LEKPERKLPFTHIIYCFQMCKINPMVK----NPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDM--DSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFI 1795
            Y+F +N+H  Q T ++    CPWC+  C K         L+KHL+  H+RFTF Y    + +     I+V +NE YDG +E G+  ++      E P R++PF H++      +   + +    + + + RP   G+ R Y++S+T +  S  +L    DSE E+N  W++    + I++FTDVN GEK++M+LWN HL++  Y  D  V     +FI
Sbjct:  358 YQFIYNSHTRQQTEARHDFCCPWCHVNCSK------LYNLLKHLKLCHSRFTFTY----APHSKGARIDVCVNEHYDGKME-GVNDALGYAFSREGPCRRVPFNHVLAWRPQRRKESLSEFLEPDDADENRPYHSGYTRTYFHSSTCVPISQSELGSLSDSEGEENPLWMRMRTIQMIDDFTDVNDGEKELMKLWNLHLMEKGYVADAQVYSACLTFI 564
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Medaka
Match: suz12a (polycomb protein suz12-A [Source:NCBI gene;Acc:101158611])

HSP 1 Score: 126.331 bits (316), Expect = 1.786e-29
Identity = 76/218 (34.86%), Postives = 109/218 (50.00%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID-------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGD 1762
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        +EV +NECYDGS   G    + N+         P ++ P TH++ C       P    PS+               R  + GHNR Y++S + +     ++D DSE E + DWL+    K+IEEFTDVN GEK+IM+LWN H++ H +  D
Sbjct:  395 YQFQYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFVFNYVPHPK----GAKVEVSINECYDGSY-AGNPQDVHNQPGFAFSRNGPVKRTPVTHVLVC------RPKRVKPSLSEFLESEDGDREQHQRTYISGHNRLYFHSDSCVPLRPQEMDEDSEDERDPDWLKEKTMKQIEEFTDVNEGEKEIMKLWNLHVMKHGFIAD 595
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Medaka
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:101158330])

HSP 1 Score: 113.62 bits (283), Expect = 1.494e-25
Identity = 73/235 (31.06%), Postives = 114/235 (48.51%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEI 1816
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+         P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WL+     +++EFTDVN GEK++M+LWN H++ H +  D  +      F+  +G  I
Sbjct:  395 YQFLYNNNTRQQTEARDDLHCPWCTLNCSK------LYSLIKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVS------RPKRTKPSLSEFLESEDGELEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLREKTSMQLDEFTDVNEGEKEVMKLWNLHVMKHGFIADNQMNQAIMLFVENRGAHI 612
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Medaka
Match: suz12a (polycomb protein suz12-A [Source:NCBI gene;Acc:101158611])

HSP 1 Score: 83.5741 bits (205), Expect = 3.625e-16
Identity = 57/187 (30.48%), Postives = 84/187 (44.92%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID-------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFK 1669
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        +EV +NECYDGS   G    + N+         P ++ P TH++ C       P    PS+               R  + GHNR Y++S + +     ++D DSE E + DWL+    K
Sbjct:  363 YQFQYNNNTRQQTEARDDLHCPWCTLNCRK------LYSLLKHLKLSHSRFVFNYVPHPK----GAKVEVSINECYDGSY-AGNPQDVHNQPGFAFSRNGPVKRTPVTHVLVC------RPKRVKPSLSEFLESEDGDREQHQRTYISGHNRLYFHSDSCVPLRPQEMDEDSEDERDPDWLKEKTMK 532
[Close]
BLAST of Polycomb protein suz12 vs. Ensembl Medaka
Match: suz12b (SUZ12 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:101158330])

HSP 1 Score: 77.7962 bits (190), Expect = 2.544e-14
Identity = 67/243 (27.57%), Postives = 103/243 (42.39%), Query Frame = 2 
Query: 1166 YKFFHNNHLLQWTRSQS-VKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENR-----LLEKPERKLPFTHIIYCFQMCKINPMVKNPSID------------LRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWL-QHMYFKRIEEFTDVNPGEKQIMQLWNSH-------LLDHKYNGDFMVPILTKSFILQKGTEI 1816
            Y+F +NN+  Q T ++  + CPWC   C K         L+KHL+  H+RF F Y   P        I+V +NECYDGS  +G    I ++         P ++   THI+         P    PS+              R  V GHNR Y++S + +     ++++DSE E + +WL +     R  E  D     K+I    N H       + D++ N   M+      F+  +G  I
Sbjct:  388 YQFLYNNNTRQQTEARDDLHCPWCTLNCSK------LYSLIKHLKLSHSRFIFNYVPHPK----GARIDVSINECYDGSY-VGNPQDIHSQPGFAFSRNGPVKRTAVTHILVS------RPKRTKPSLSEFLESEDGELEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLREKTSMVRTGEICDSGNWRKKIWGFLNEHTVKKNIFIADNQMNQAIML------FVENRGAHI 607
[Close]
BLAST of Polycomb protein suz12 vs. Planmine SMEST
Match: SMESG000054377.1 (SMESG000054377.1)

HSP 1 Score: 1116.29 bits (2886), Expect = 0.000e+0
Identity = 607/607 (100.00%), Postives = 607/607 (100.00%), Query Frame = 2 
Query:  107 MDYLRNGNCCQQRPEDLNYEYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFXXXXXXXXXXCERLVKIRIPRVRSSVDTNHFSTIKDINWNLIFIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPXXXXXXXXXXXXVFDNVTDSPERIWVREVSPTNSVAKEYDKWPRILFKLESSNFQSKLETNHVDFKSHILNGXXXXXXXXXXXXXXXXXXVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEIKXXXXXXXXXXXXXXXXXXXXXSQKQLIEVIGLLDQM 1927
            MDYLRNGNCCQQRPEDLNYEYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFKKKLKKIDKICERLVKIRIPRVRSSVDTNHFSTIKDINWNLIFIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPTESLSGSTTSESVFDNVTDSPERIWVREVSPTNSVAKEYDKWPRILFKLESSNFQSKLETNHVDFKSHILNGVVDKIVKKPKKFKLDVNVVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEIKEHNLRNNLLLHLVNLVEFGLLSQKQLIEVIGLLDQM
Sbjct:    1 MDYLRNGNCCQQRPEDLNYEYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFKKKLKKIDKICERLVKIRIPRVRSSVDTNHFSTIKDINWNLIFIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDNDLKFYLLPGEYEMRLEVSLDQPTESLSGSTTSESVFDNVTDSPERIWVREVSPTNSVAKEYDKWPRILFKLESSNFQSKLETNHVDFKSHILNGVVDKIVKKPKKFKLDVNVVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFHARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYNGDFMVPILTKSFILQKGTEIKEHNLRNNLLLHLVNLVEFGLLSQKQLIEVIGLLDQM 607
[Close]
BLAST of Polycomb protein suz12 vs. Planmine SMEST
Match: SMESG000035646.1 (SMESG000035646.1)

HSP 1 Score: 94.7449 bits (234), Expect = 7.770e-20
Identity = 68/219 (31.05%), Postives = 111/219 (50.68%), Query Frame = 2 
Query: 1163 VYKFFHNNHLLQWTRSQSVKCPWC--NFICEKNTTKLSFNCLMKHLQTFHARFTF---KYFGIPSVN-ISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPERKLPFTHIIYC-FQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIGDLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHK-YNGDFMVPILTKSFI 1795
             YKF     ++QWT+++ + CPWC  NF    N    +F  L+ HL  +H+R  F   K     ++N  + I ++V LN+      + G   S EN     P R++P T +IY  +Q   +    K            HNR Y ++ + +     + D+DSE+E+N  WL   Y++++EEF+D+N  EK+++Q+WN  LL +  Y  D  +    K+FI
Sbjct:  420 AYKFVVKEKIVQWTQTKHLICPWCLLNF-NSGNDLYNTFQQLLSHLNNWHSRLVFTCKKLKNRMTLNKTNKITVDVNLNQVNPNDFDFGYVLS-ENY----PVRRMPLTELIYYRYQKSAVKTFRK-----------YHNRLYSHTWSAMSLKDDEFDIDSESEENKQWLFDQYYRKVEEFSDLNHIEKKVIQMWNHELLSYGIYVSDSQLENFVKNFI 621

HSP 2 Score: 53.5286 bits (127), Expect = 6.354e-7
Identity = 58/263 (22.05%), Postives = 107/263 (40.68%), Query Frame = 2 
Query:  164 EYEEIIKRLGHISSLYGYLKINFKRSHFLLFRNLSYIQGNQNSFXXXXXXXXXXCERLVKIRIPRVRSSVDTNHFSTIK--DINWNLI--------------------FIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLSNLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFERRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDN--DLKFYLLPGEYEMRLEVS 880
            E+++ +K     S++Y  L +  K +  +L RNLSY+  ++                   I+   +R+  D  H ST++  D N  L+                    F  F DS  E  W+TI     + ++H ++++RK +      + +S   IKCN     D +  QK H    + + +  N  RV  S   FK+   E++         N + +     Y V YE   P +    + N     +++  G+Y++ ++V+
Sbjct:   64 EFQDFLKHFMIPSNIYKNLALRHKTNPIILKRNLSYLNHSK-----------------TDIQKSNLRTIAD--HLSTVRFHDENLALMKGKLPIKPNYPNYPNKVIFKFDQFVDSKTEKDWKTIEGIVYMDIVHFYRDNRKNKESFTVKRVISGQKIKCNE----DMKSEQKSHSINIADIMKSANFYRVYKSVFHFKVLAKEKK--------LNGKEDKTGDIYPVTYEAMMPLFSNTCSRNLRSSNYFVQSGKYQIYMDVT 295
The following BLAST results are available for this feature:
BLAST of Polycomb protein suz12 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
SUZ124.301e-2633.65SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
SUZ124.530e-2633.65SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Polycomb protein suz12 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Su(z)124.364e-2933.76gene:FBgn0020887 transcript:FBtr0074916[more]
Su(z)124.455e-2933.76gene:FBgn0020887 transcript:FBtr0074917[more]
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BLAST of Polycomb protein suz12 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
suz12a2.493e-2733.48SUZ12 polycomb repressive complex 2 subunit a [Sou... [more]
suz12b1.115e-2633.64SUZ12 polycomb repressive complex 2 subunit b [Sou... [more]
suz12b1.301e-2534.62SUZ12 polycomb repressive complex 2 subunit b [Sou... [more]
suz12b1.306e-2534.62SUZ12 polycomb repressive complex 2 subunit b [Sou... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
suz121.543e-2633.65SUZ12, polycomb repressive complex 2 subunit [Sour... [more]
suz121.686e-2633.65SUZ12, polycomb repressive complex 2 subunit [Sour... [more]
suz121.914e-2633.65SUZ12, polycomb repressive complex 2 subunit [Sour... [more]
suz121.931e-2633.65SUZ12, polycomb repressive complex 2 subunit [Sour... [more]
suz121.957e-2633.65SUZ12, polycomb repressive complex 2 subunit [Sour... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Suz122.866e-2633.65SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
Suz122.942e-2633.65SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
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BLAST of Polycomb protein suz12 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9NJG9|SUZ12_DROME4.466e-2833.76Polycomb protein Su(z)12 OS=Drosophila melanogaste... [more]
sp|Q6DC03|SZ12A_DANRE2.037e-2633.48Polycomb protein suz12-A OS=Danio rerio OX=7955 GN... [more]
sp|B0R1D5|SZ12B_DANRE8.414e-2633.64Polycomb protein suz12-B OS=Danio rerio OX=7955 GN... [more]
sp|Q0VA03|SUZ12_XENTR9.096e-2633.65Polycomb protein suz12 OS=Xenopus tropicalis OX=83... [more]
sp|Q80U70|SUZ12_MOUSE2.005e-2533.65Polycomb protein Suz12 OS=Mus musculus OX=10090 GN... [more]
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BLAST of Polycomb protein suz12 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A481NWA70.000e+081.05Polycomb protein SUZ12-2 OS=Dugesia japonica OX=61... [more]
A0A267F4W92.686e-3327.15VEFS-Box domain-containing protein (Fragment) OS=M... [more]
A0A267G2X84.722e-3327.17VEFS-Box domain-containing protein OS=Macrostomum ... [more]
A0A4E0RKT32.498e-3135.32VEFS-Box domain-containing protein OS=Fasciola hep... [more]
A0A088A7L13.117e-3134.75VEFS-Box domain-containing protein OS=Apis mellife... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
suz12b7.031e-2733.64SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
suz12b1.087e-2633.64SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
suz12a1.438e-2530.64polycomb protein suz12-A-like [Source:NCBI gene;Ac... [more]
suz12a1.691e-2530.64polycomb protein suz12-A-like [Source:NCBI gene;Ac... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
suz12a7.839e-2733.49SUZ12 polycomb repressive complex 2 subunit a [Sou... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Polycomb protein suz12 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO426509.070e-2533.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Polycomb protein suz12 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
suz12a1.786e-2934.86polycomb protein suz12-A [Source:NCBI gene;Acc:101... [more]
suz12b1.494e-2531.06SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
suz12a3.625e-1630.48polycomb protein suz12-A [Source:NCBI gene;Acc:101... [more]
suz12b2.544e-1427.57SUZ12 polycomb repressive complex 2 subunit [Sourc... [more]
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BLAST of Polycomb protein suz12 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000054377.10.000e+0100.00SMESG000054377.1[more]
SMESG000035646.17.770e-2031.05SMESG000035646.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000594 ID=SMED30000594|Name=Polycomb protein suz12|organism=Schmidtea mediterranea sexual|type=transcript|length=2402bp
AAAATATTGAAAATTTAATTAGATAATAATTTTTTAAGAGTATACTGAAT
TATATGGAAAATACAATTTTAATTTCTTAACAAATTCAAACCATTAATTA
ATTTTAATGGATTATCTTCGTAATGGAAATTGCTGTCAACAACGGCCAGA
AGACCTGAATTATGAGTACGAAGAAATTATTAAGAGACTTGGTCATATTA
GTTCTTTGTACGGATATTTAAAAATTAATTTTAAAAGATCTCATTTTTTA
TTGTTTCGAAATTTGTCTTACATTCAGGGTAATCAGAATTCCTTTAAAAA
AAAACTTAAAAAGATAGATAAAATATGTGAAAGACTTGTTAAAATACGAA
TTCCTCGTGTTAGATCATCAGTGGATACAAATCATTTCTCAACCATAAAA
GATATAAATTGGAATTTGATTTTTATTGGATTTTTTGATAGCTTCCACGA
GTCTCAATGGGAGACAATCAATGCCTGTGCTGATATTTACGTTATTCATC
ATTGGAAAAATAGTCGAAAATTCCAGAGCGGTAAAATGACAGCTAAATTT
CTTTCGAATCTTCCAATAAAATGCAACGGTAGACCGACAATTGATGATGA
AAGATTTCAGAAAAAACACGAATTTGTACAGTCGCAACTATTCCAGGACA
CAAATCACCTACGAGTCGTTTATTCGTATTTATTGTTCAAGTTGCGCGTT
TTCGAACGTCGTACTGCTGACGGTTCAAAGATCGACGCCAATGCACAAGT
CAACCATAACAATGGTCATTACGCTGTACACTACGAACTGAAGTTTCCAT
TTTACAAGTTCCGTTCAAATGATAATGATTTGAAATTTTATCTATTACCG
GGTGAATACGAGATGCGTCTAGAAGTTAGCCTAGATCAACCTACAGAGTC
TCTCTCTGGCTCCACAACCAGTGAATCAGTGTTTGATAATGTCACTGATT
CACCGGAACGGATTTGGGTGAGGGAAGTCAGCCCAACTAACAGTGTTGCT
AAAGAATATGACAAATGGCCAAGAATTCTATTCAAACTTGAATCTTCCAA
TTTTCAAAGCAAACTTGAAACGAATCATGTTGATTTTAAATCACATATTT
TAAATGGCGTCGTTGATAAAATTGTGAAAAAACCAAAGAAATTCAAACTA
GATGTAAATGTTGTATATAAATTCTTTCACAATAATCATCTTTTACAATG
GACTCGAAGCCAGTCAGTCAAATGTCCGTGGTGCAATTTTATTTGTGAAA
AAAATACGACTAAATTGAGTTTTAATTGTTTAATGAAACATTTGCAGACT
TTCCATGCCAGATTTACATTTAAATATTTTGGGATACCAAGTGTAAATAT
TTCATCAATCATTATCGAAGTCAGACTAAATGAGTGCTATGATGGATCTA
TTGAAATTGGACTTAGAAGTTCTATTGAAAATAGATTGCTTGAAAAACCC
GAGAGAAAGCTTCCATTTACACACATAATATATTGTTTCCAGATGTGCAA
AATCAATCCTATGGTAAAAAATCCTTCAATTGATTTACGACCGATAGTTT
GGGGTCACAATAGAAAATATTATTATTCCACTACTGGAATTATGAAATCT
ATCGGAGATTTAGATATGGATTCTGAGACAGAAGATAATCTTGATTGGTT
ACAACATATGTATTTTAAAAGAATTGAAGAATTCACAGATGTTAATCCGG
GAGAAAAACAAATCATGCAGTTGTGGAATTCTCATTTACTAGATCATAAA
TATAATGGCGATTTTATGGTGCCGATTCTCACCAAGTCATTTATCCTTCA
AAAAGGAACAGAAATCAAGGAACATAATCTGCGAAACAATTTGCTACTTC
ATTTAGTCAATTTGGTGGAATTCGGTCTGTTGAGTCAGAAACAATTGATA
GAAGTTATAGGATTATTGGATCAAATGTAAATCTGCCTCCATCAATTACC
GTTGGCATTTATTTTAGTTTTATTCTTTTGATATCGGGAATCCATTCGAT
TCTTGTTTTAGTGGCCTTTAAACAAATTATTCTTCTTCTTATTATTCTTA
TTATTTCATTAAGCAAAATTGTGATGCAACTTGACTTTATATTGTGATCT
TGTAATATCAACCTGTGGGTTATTTGTAAACTATCCAGGGATTAGCTATA
TTAAATTTTTGTAGCCTTATTTTGATCGTAGATATGCGGTCTATATCACT
GTTAATTGTGTTATTTTGTCGAGCTAGTACACATCTAAATGGCTCATGTC
GTTTTTCGATCATGTACGTTGTTTGATTGGTTGTTTATTTACACCTCTTT
ATTATTGTTGTTATTGTTTACTTTGCTATTGTTAGTAATATTATTCTAAT
TGTTTTCTATTATATACCACTAGTATTTGTTGTGAAGATTAAATAAGCTG
CA
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protein sequence of SMED30000594-orf-1

>SMED30000594-orf-1 ID=SMED30000594-orf-1|Name=SMED30000594-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=608bp
MDYLRNGNCCQQRPEDLNYEYEEIIKRLGHISSLYGYLKINFKRSHFLLF
RNLSYIQGNQNSFKKKLKKIDKICERLVKIRIPRVRSSVDTNHFSTIKDI
NWNLIFIGFFDSFHESQWETINACADIYVIHHWKNSRKFQSGKMTAKFLS
NLPIKCNGRPTIDDERFQKKHEFVQSQLFQDTNHLRVVYSYLLFKLRVFE
RRTADGSKIDANAQVNHNNGHYAVHYELKFPFYKFRSNDNDLKFYLLPGE
YEMRLEVSLDQPTESLSGSTTSESVFDNVTDSPERIWVREVSPTNSVAKE
YDKWPRILFKLESSNFQSKLETNHVDFKSHILNGVVDKIVKKPKKFKLDV
NVVYKFFHNNHLLQWTRSQSVKCPWCNFICEKNTTKLSFNCLMKHLQTFH
ARFTFKYFGIPSVNISSIIIEVRLNECYDGSIEIGLRSSIENRLLEKPER
KLPFTHIIYCFQMCKINPMVKNPSIDLRPIVWGHNRKYYYSTTGIMKSIG
DLDMDSETEDNLDWLQHMYFKRIEEFTDVNPGEKQIMQLWNSHLLDHKYN
GDFMVPILTKSFILQKGTEIKEHNLRNNLLLHLVNLVEFGLLSQKQLIEV
IGLLDQM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006325chromatin organization
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0008284positive regulation of cell proliferation
GO:0016569covalent chromatin modification
GO:0016571histone methylation
GO:0016574histone ubiquitination
GO:0045596negative regulation of cell differentiation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR019135Polycomb_protein_VEFS-Box
Vocabulary: molecular function
TermDefinition
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding
GO:0003682chromatin binding
GO:0003723RNA binding
GO:0005515protein binding
GO:0031490chromatin DNA binding
GO:0035064methylated histone binding
GO:0042054histone methyltransferase activity
GO:0043565sequence-specific DNA binding
GO:0046872metal ion binding
GO:1990841promoter-specific chromatin binding
Vocabulary: cellular component
TermDefinition
GO:0001739sex chromatin
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005694chromosome
GO:0005730nucleolus
GO:0016586RSC complex
GO:0016604nuclear body
GO:0032993protein-DNA complex
GO:0035098ESC/E(Z) complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR019135Polycomb protein, VEFS-BoxPFAMPF09733VEFS-Boxcoord: 476..599
e-value: 1.5E-30
score: 105.8
NoneNo IPR availablePANTHERPTHR22597:SF0POLYCOMB PROTEIN SUZ12coord: 349..439
coord: 479..606
NoneNo IPR availablePANTHERPTHR22597POLYCOMB GROUP PROTEINcoord: 349..439
coord: 479..606