Epithelial discoidin domain-containing receptor

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  650 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR----QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 938          

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  724 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1012          

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  788 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1076          

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  780 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1068          

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  740 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1028          

Query: 2343 LIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPC----PQNCPKDIY-DLMNRCWNWDESARPKFADVHKFLQ 3230
            LI + ++ +GEFG + +C +          +  VK L+  S++   S F  ++++L S+   N+V  E + V +    I             IM+Y+   +LK ++        SQ   +   +                 A G+ +LE     HRD+A RNC++D   +VKI   G+  +  +++Y  +E        P+RWMA E+++ G F+T SD+W F VT+WEIF+LCS  PY  +T++ +++ +   ++T  L      P+ CP  +Y + +  CWN++ S RP F +VH  LQ
Sbjct:  497 LICVSRIGQGEFGEVDLCQL-------ENRKVAVKKLHGISQADEFS-FHREIRVLGSLKHPNVV--EVVGVCTIQKPI-----------LCIMEYMENGDLKSYILKNPTIQTSQCISICTQL-----------------AAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVE---GKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 756          

Query:  426 MSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNL-RTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGT--LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHN--IYLSGLITVTISDRD 1265
            MS + + D+Q SASS  +  Q +  +    H +SG     AWCP   I+S  +EW+++ F    +I  + T GR  DG   +Y     I+Y R + N W +Y +      +  N D    +R +L R IIA+RIRI P+++  S+   C++    GC  +D  V Y+  QGDL +   IS+   D+ YDG +  +  L  G+G L D    +N  ++F  VN  K   + GW    R ++  + + F F + R+   I +++  +FK +   + S  +  +I+ +D
Sbjct:    1 MSNRKIRDEQISASS-SFDLQSTGPQHARAHQESG---SGAWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSN--STRTVCMRVEVFGCPFDDSLVFYNVDQGDLQS--GISY--HDFSYDGNLANSPHLTGGIGKLYDGEVGKN--NVF--VNHHK---WVGW---RRKRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKD 266          

Query: 2343 LIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPC----PQNCPKDIY-DLMNRCWNWDESARPKFADVHKFLQ 3230
            LI + ++ +GEFG + +C +          +  VK L+  S++   S F  ++++L S+   N+V  E + V +    I             IM+Y+   +LK ++        SQ   +   +                 A G+ +LE     HRD+A RNC++D   +VKI   G+  +  +++Y  +E        P+RWMA E+++ G F+T SD+W F VT+WEIF+LCS  PY  +T++ +++ +   ++T  L      P+ CP  +Y + +  CWN++ S RP F +VH  LQ
Sbjct:  497 LICVSRIGQGEFGEVDLCQL-------ENRKVAVKKLHGISQADEFS-FHREIRVLGSLKHPNVV--EVVGVCTIQKPI-----------LCIMEYMENGDLKSYILKNPTIQTSQCISICTQL-----------------AAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVE---GKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 756          

Query:  426 MSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNL-RTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGT--LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHN--IYLSGLITVTISDRD 1265
            MS + + D+Q SASS  +  Q +  +    H +SG     AWCP   I+S  +EW+++ F    +I  + T GR  DG   +Y     I+Y R + N W +Y +      +  N D    +R +L R IIA+RIRI P+++  S+   C++    GC  +D  V Y+  QGDL +   IS+   D+ YDG +  +  L  G+G L D    +N  ++F  VN  K   + GW    R ++  + + F F + R+   I +++  +FK +   + S  +  +I+ +D
Sbjct:    1 MSNRKIRDEQISASS-SFDLQSTGPQHARAHQESG---SGAWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSN--STRTVCMRVEVFGCPFDDSLVFYNVDQGDLQS--GISY--HDFSYDGNLANSPHLTGGIGKLYDGEVGKN--NVF--VNHHK---WVGW---RRKRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKD 266          

Query: 2343 LIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPC----PQNCPKDIY-DLMNRCWNWDESARPKFADVHKFLQ 3230
            LI + ++ +GEFG + +C +          +  VK L+  S++   S F  ++++L S+   N+V  E + V +    I             IM+Y+   +LK ++        SQ   +   +                 A G+ +LE     HRD+A RNC++D   +VKI   G+  +  +++Y  +E        P+RWMA E+++ G F+T SD+W F VT+WEIF+LCS  PY  +T++ +++ +   ++T  L      P+ CP  +Y + +  CWN++ S RP F +VH  LQ
Sbjct:  527 LICVSRIGQGEFGEVDLCQL-------ENRKVAVKKLHGISQADEFS-FHREIRVLGSLKHPNVV--EVVGVCTIQKPI-----------LCIMEYMENGDLKSYILKNPTIQTSQCISICTQL-----------------AAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVE---GKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 786          

Query:  426 MSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNL-RTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGT--LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHN--IYLSGLITVTISDRD 1265
            MS + + D+Q SASS  +  Q +  +    H +SG     AWCP   I+S  +EW+++ F    +I  + T GR  DG   +Y     I+Y R + N W +Y +      +  N D    +R +L R IIA+RIRI P+++  S+   C++    GC  +D  V Y+  QGDL +   IS+   D+ YDG +  +  L  G+G L D    +N  ++F  VN  K   + GW    R ++  + + F F + R+   I +++  +FK +   + S  +  +I+ +D
Sbjct:   31 MSNRKIRDEQISASS-SFDLQSTGPQHARAHQESG---SGAWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSN--STRTVCMRVEVFGCPFDDSLVFYNVDQGDLQS--GISY--HDFSYDGNLANSPHLTGGIGKLYDGEVGKN--NVF--VNHHK---WVGW---RRKRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKD 296          

Query: 2487 FIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVH 3218
            F+ +  I+  ++  NLV+L             L        FYII +++   NL ++LR T  S +     L Q              + +Q+A+GM +LE     HRDLA RNC++     VKI   GL      + Y +    +    FP++W APE +    F++KSD+W+F V LWEI T   + PY  +    +  L+    N  R+  PQ CP  +Y LM +CWNW  S RP+F D+H
Sbjct:  337 FLAEAAIMKDLHHKNLVRL-------------LGVCTHEAPFYIITEFMCNGNLLEYLRRTDKS-LLPPIILVQ--------------MASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTA----HAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATY-GMAPYPGVELSNVYGLLE---NGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIH 544          

Query: 2487 FIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVH 3218
            F+ +  I+  ++  NLV+L             L        FYII +++   NL ++LR T  S +     L Q              + +Q+A+GM +LE     HRDLA RNC++     VKI   GL      + Y +    +    FP++W APE +    F++KSD+W+F V LWEI T   + PY  +    +  L+    N  R+  PQ CP  +Y LM +CWNW  S RP+F D+H
Sbjct:  352 FLAEAAIMKDLHHKNLVRL-------------LGVCTHEAPFYIITEFMCNGNLLEYLRRTDKS-LLPPIILVQ--------------MASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTA----HAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATY-GMAPYPGVELSNVYGLLE---NGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIH 559          

Query: 2283 FPRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGY-NLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPN--EDYCSMEILNHLVT--FPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMS--HRNNTPR--LPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFK 3236
            F  +++  ++  ++  P  SL+ ++++  G FG + +C    E +        V  L   +   ++  F    K L+ ++  N+ +L             + + ++     I+ DY +   +L  FL+     +V++   L   M    +S   L+ I TQ+A+GMKHLE++   HRDLA R+C+I   + VK+   G V  +     DYC +E      +   P+RWMA ES++ G FTTKSD+WSFAV LWEI T     PY  L+++++++ +   +R+      LP P NCP++IYDLM  CW  DES+RP F ++H +LQ K
Sbjct:  739 FADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLC----ETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARL-------------VGACLRDEPICIVQDYSHCLGDLNQFLQE----HVAETSGL---MAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRK 1041          

Query:  426 MSPKYLTDDQFSASSFE--YKFQPSAARL-IEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLR-TIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILG-TLQNGLGLLMDNIAWRNKFDLFNNVNG-EKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHN--IYLSGLITVTISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSI 1442
            M    + D Q +ASS        P  ARL I+       ++G AWCP   +     E+++VD   + ++  I T GR   G  Q+YT   +I+Y R    +W  + +L  + VL  N +  +++ + L+ ++ A ++R+YP +    ++  CL+   +GC  E+  VSY  P+G       +  DL D  YDG   G    NGLG L+D    R K +   ++NG  K   + GW   +    P  II F FE  R+  ++ +++   F  +  +++   +  +I  R  +   +  +        +   VT++L+H  G    +++      ++++SEI   SA  +
Sbjct:  112 MESGAIADFQITASSAHDMGNVGPQHARLKID-------NNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTV--CLRAEIVGCAWEEGIVSYSIPKG---MQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVD--GQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEII-FEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFA-ARWMMISEITFISAPVV 443          

Query: 2283 FPRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGY-NLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPN--EDYCSMEILNHLVT--FPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMS--HRNNTPR--LPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFK 3236
            F  +++  ++  ++  P  SL+ ++++  G FG + +C    E +        V  L   +   ++  F    K L+ ++  N+ +L             + + ++     I+ DY +   +L  FL+     +V++   L   M    +S   L+ I TQ+A+GMKHLE++   HRDLA R+C+I   + VK+   G V  +     DYC +E      +   P+RWMA ES++ G FTTKSD+WSFAV LWEI T     PY  L+++++++ +   +R+      LP P NCP++IYDLM  CW  DES+RP F ++H +LQ K
Sbjct:  739 FADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLC----ETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARL-------------VGACLRDEPICIVQDYSHCLGDLNQFLQE----HVAETSGL---MAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRK 1041          

Query:  426 MSPKYLTDDQFSASSFE--YKFQPSAARL-IEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLR-TIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILG-TLQNGLGLLMDNIAWRNKFDLFNNVNG-EKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHN--IYLSGLITVTISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSI 1442
            M    + D Q +ASS        P  ARL I+       ++G AWCP   +     E+++VD   + ++  I T GR   G  Q+YT   +I+Y R    +W  + +L  + VL  N +  +++ + L+ ++ A ++R+YP +    ++  CL+   +GC  E+  VSY  P+G       +  DL D  YDG   G    NGLG L+D    R K +   ++NG  K   + GW   +    P  II F FE  R+  ++ +++   F  +  +++   +  +I  R  +   +  +        +   VT++L+H  G    +++      ++++SEI   SA  +
Sbjct:  112 MESGAIADFQITASSAHDMGNVGPQHARLKID-------NNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTV--CLRAEIVGCAWEEGIVSYSIPKG---MQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVD--GQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEII-FEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFA-ARWMMISEITFISAPVV 443          

Query: 2541 LETIAVDSDMSNIDLFSVI----KSTRFYIIMDYLNGYNLKDFLRSTYYSN---VSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            LE  A+  +M + +L  +I    +   FYII ++++  NL DFLRS        V+  +  TQ                  +A+GM +LE     HRDLA RNC++     VK+   GL     ++ Y +    +    FP++W APE +    F+TKSD+W+F V LWEI T   + PY ++    L D+    +   R+  P  CP ++YDLM +CW WD + RP F  +H  L+
Sbjct:  413 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQ------------------IASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTA----HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATY-GMSPYPAID---LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 623          

Query: 2541 LETIAVDSDMSNIDLFSVI----KSTRFYIIMDYLNGYNLKDFLRSTYYSN---VSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            LE  A+  +M + +L  +I    +   FYII ++++  NL DFLRS        V+  +  TQ                  +A+GM +LE     HRDLA RNC++     VK+   GL     ++ Y +    +    FP++W APE +    F+TKSD+W+F V LWEI T   + PY ++    L D+    +   R+  P  CP ++YDLM +CW WD + RP F  +H  L+
Sbjct:  413 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQ------------------IASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTA----HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATY-GMSPYPAID---LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 623          

Query: 2541 LETIAVDSDMSNIDLFSVI----KSTRFYIIMDYLNGYNLKDFLRSTYYSN---VSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            LE  A+  +M + +L  +I    +   FYII ++++  NL DFLRS        V+  +  TQ                  +A+GM +LE     HRDLA RNC++     VK+   GL     ++ Y +    +    FP++W APE +    F+TKSD+W+F V LWEI T   + PY ++    L D+    +   R+  P  CP ++YDLM +CW WD + RP F  +H  L+
Sbjct:  413 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQ------------------IASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTA----HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATY-GMSPYPAID---LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 623          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM------------LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            Y  P   VD     D ++   P   L+  +++  G+FG + +C              L E D +      VK L  D+ S+ ++ F+ ++KI+S +N  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +S++ L+ +  Q+++GMK+L  L   HRDLA RNC++D  + +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC   PY  L++E ++    +   ++     L  P  CP  ++ LM RCW+ D + RP F  +H+ L+
Sbjct:  541 YSVPALTVDSLTRKDISVAEFPRQRLLFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRPVL-VAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSSD-------------PLCMVTEYMENGDLNMFL-----SQREIESTLTHANNIPSVSIADLLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIENTGEFFRNQGRQIFLSAPPLCPSSLFKLMMRCWSRDITDRPSFNKLHQALR 855          

Query:  426 MSPKYLTDDQFSASSFEY-KFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNN--QWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISF-DLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKD----PFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVT-----ISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAI 1484
            M    + +D  +ASS  Y    P  ARL     +       AWC    +     +++++D R+++ +  + T GR A  +  ++  +  ++Y R  +    WRN     NE ++       T +R     II + +R+ P+     ++  C++    GC  +D  ++Y +P+G ++         L D  YDG +    L  GLG L D +   + F     V   + +++ G+       D     ++ + F F+++R+F S+ ++S   F   + +   ++       IS+ ++  V  +  I   D + +   VTV L H              + +++ SEI  +S   +       P K+P +
Sbjct:   17 MEDGRIKNDDITASSQWYDSTGPQYARLNREEGE------GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSRDGHRWISWRN--RFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTV--CMRVELFGCAWQDGLMAYSSPEGQIMMAPGFPITSLNDSTYDGPLERRKLSGGLGQLADGVVGLDDF-----VESRQYRLWPGYDYVGWRNDGLGPAYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKLHLISEWESEPVEFHTVI--DDRNPSARYVTVPLKHRSATALRCRFYFA-DTWMMFSEISFQSVTIVL------PTKKPPV 360          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM------------LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            Y  P   VD     D ++   P   L+  +++  G+FG + +C              L E D +      VK L  D+ S+ ++ F+ ++KI+S +N  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +S++ L+ +  Q+++GMK+L  L   HRDLA RNC++D  + +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC   PY  L++E ++    +   ++     L  P  CP  ++ LM RCW+ D + RP F  +H+ L+
Sbjct:  553 YSVPALTVDSLTRKDISVAEFPRQRLLFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRPVL-VAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSSD-------------PLCMVTEYMENGDLNMFL-----SQREIESTLTHANNIPSVSIADLLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIENTGEFFRNQGRQIFLSAPPLCPSSLFKLMMRCWSRDITDRPSFNKLHQALR 867          

Query:  426 MSPKYLTDDQFSASSFEY-KFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNN--QWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISF-DLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKD----PFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVT-----ISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGL---NNFILLSEIEIKSAKSIRTNAANSPPKRPAI 1484
            M    + +D  +ASS  Y    P  ARL     +       AWC    +     +++++D R+++ +  + T GR A  +  ++  +  ++Y R  +    WRN     NE ++       T +R     II + +R+ P+     ++  C++    GC  +D  ++Y +P+G ++         L D  YDG +    L  GLG L D +   + F     V   + +++ G+       D     ++ + F F+++R+F S+ ++S   F   + +   ++       IS+ ++  V  +  I   D + +   VTV L H      +  + C     + +++ SEI  +S   +       P K+P +
Sbjct:   29 MEDGRIKNDDITASSQWYDSTGPQYARLNREEGE------GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSRDGHRWISWRN--RFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTV--CMRVELFGCAWQDGLMAYSSPEGQIMMAPGFPITSLNDSTYDGPLERRKLSGGLGQLADGVVGLDDF-----VESRQYRLWPGYDYVGWRNDGLGPAYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKLHLISEWESEPVEFHTVI--DDRNPSARYVTVPLKHRS----ATALRCRFYFADTWMMFSEISFQSVTIVL------PTKKPPV 372          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCT------MLIEG-----DHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            Y  P   VD     D ++   P   L+  +++  G+FG + +C        L EG              VK L  D+ S+ ++ F+ ++KI+S +N  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +S++ L+ +  Q+++GMK+L  L   HRDLA RNC++D  + +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC   PY  L++E ++    +   ++     L  P  CP  ++ LM RCW+ D + RP F  +H+ L+
Sbjct:  531 YSVPALTVDSLTRKDISVAEFPRQRLLFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRPVLVAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSSD-------------PLCMVTEYMENGDLNMFL-----SQREIESTLTHANNIPSVSIADLLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIENTGEFFRNQGRQIFLSAPPLCPSSLFKLMMRCWSRDITDRPSFNKLHQALR 845          

Query:  426 MSPKYLTDDQFSASSFEY-KFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNN--QWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISF-DLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKD----PFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVT-----ISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAI 1484
            M    + +D  +ASS  Y    P  ARL     +       AWC    +     +++++D R+++ +  + T GR A  +  ++  +  ++Y R  +    WRN     NE ++       T +R     II + +R+ P+     ++  C++    GC  +D  ++Y +P+G ++         L D  YDG +    L  GLG L D +   + F     V   + +++ G+       D     ++ + F F+++R+F S+ ++S   F   + +   ++       IS+ ++  V  +  I   D + +   VT+ L H              + +++ SEI  +S   +       P K+P +
Sbjct:   29 MEDGRIKNDDITASSQWYDSTGPQYARLNREEGE------GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSRDGHRWISWRN--RFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTV--CMRVELFGCAWQDGLMAYSSPEGQIMMAPGFPITSLNDSTYDGPLERRKLSGGLGQLADGVVGLDDF-----VESRQYRLWPGYDYVGWRNDGLGPGYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKLHLISEWESEPVEFHTVI--DDRNPSARYVTIPLKHRSATALRCRFYFA-DTWMMFSEISFQSVTIVL------PTKKPPV 372          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCT------MLIEG-----DHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            Y  P   VD     D ++   P   L+  +++  G+FG + +C        L EG              VK L  D+ S+ ++ F+ ++KI+S +N  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +S++ L+ +  Q+++GMK+L  L   HRDLA RNC++D  + +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC   PY  L++E ++    +   ++     L  P  CP  ++ LM RCW+ D + RP F  +H+ L+
Sbjct:  531 YSVPALTVDSLTRKDISVAEFPRQRLLFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRPVLVAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSSD-------------PLCMVTEYMENGDLNMFL-----SQREIESTLTHANNIPSVSIADLLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIENTGEFFRNQGRQIFLSAPPLCPSSLFKLMMRCWSRDITDRPSFNKLHQALR 845          

Query:  426 MSPKYLTDDQFSASSFEY-KFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNN--QWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISF-DLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKD----PFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVT-----ISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAI 1484
            M    + +D  +ASS  Y    P  ARL     +       AWC    +     +++++D R+++ +  + T GR A  +  ++  +  ++Y R  +    WRN     NE ++       T +R     II + +R+ P+     ++  C++    GC  +D  ++Y +P+G ++         L D  YDG +    L  GLG L D +   + F     V   + +++ G+       D     ++ + F F+++R+F S+ ++S   F   + +   ++       IS+ ++  V  +  I   D + +   VTV L H              + +++ SEI  +S   +       P K+P +
Sbjct:   29 MEDGRIKNDDITASSQWYDSTGPQYARLNREEGE------GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSRDGHRWISWRN--RFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTV--CMRVELFGCAWQDGLMAYSSPEGQIMMAPGFPITSLNDSTYDGPLERRKLSGGLGQLADGVVGLDDF-----VESRQYRLWPGYDYVGWRNDGLGPAYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKLHLISEWESEPVEFHTVI--DDRNPSARYVTVPLKHRSATALRCRFYFA-DTWMMFSEISFQSVTIVL------PTKKPPV 372          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            ++GMK+L  L   HRDLA RNC++ +   +KI   G+       DY  ++        P+RWM+ ESI+ G FT  SD+W+F VTLWEI TLC   PY   T+E ++    +    +N    L  P  CP+ +Y LM  CW  +   RP F ++H  L
Sbjct:    6 SSGMKYLSSLNFVHRDLATRNCLVGMNNIIKIADFGMSRNLYRGDYYRIQ---GRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYAQFTDEQVIENTGEFFRDQNKQVYLLRPACCPESLYSLMLNCWRRNAKERPTFLEIHSTL 160          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
             P   L+  +++  G+FG + +C ++   +  T    F           VK L  D+  + +S F+ +LKILS ++  ++++L    +D D                +I +Y+   +L  FL S +     +     Q +P   IS  SL+ +  Q+ +GMK+L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWEI  LC   PYG L++E ++    ++         L  P  CP+ +Y+LM +CW+ D   RP F D+H  L
Sbjct:  604 FPRGHLLFKEKLGEGQFGEVHLCEVVNPHELPTLQFPFNMRKGRSLLVAVKLLRADANKNARSDFLKELKILSRLSDPHIIRLLGACLDED-------------PLCMITEYMENGDLNQFLSSHHLDEGEESG--AQCLP--AISYPSLLHVAVQICSGMKYLSSLNFVHRDLASRNCLVGENFTIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDSKKQIFLFRPPPCPQPLYELMLQCWSRDCRERPSFQDIHALL 898          

Query:  516 HSQSGPDDGN-AWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAIL 998
            HS+   +DG+ AWCP   +    EE+++VD R +  +  + T GR  G   K +     ++Y R +  +W  + +     V+  N +    +  +L   IIA+ +R YP+      M  CL+    GC  +D   SY +P G+++++ ++  +L D  YDG  +
Sbjct:   63 HSRLESNDGDGAWCPLGPVFPNYEEFLQVDLRNLHFLTLVGTQGRDGGGLGKEFARHYQLRYSR-DGFKWSQWRDRWGNEVIEGNENTHDSVLKDLGPPIIARYVRFYPMAD--RVMSVCLRVELYGCIWQDGLRSYTSPPGNVMSLPSMLINLNDSTYDGFTV 223          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
             P   L+  +++  G+FG + +C ++   +  T    F           VK L  D+  + +S F+ +LKILS ++  ++++L    +D D                +I +Y+   +L  FL S +     +     Q +P   IS  SL+ +  Q+ +GMK+L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWEI  LC   PYG L++E ++    ++         L  P  CP+ +Y+LM +CW+ D   RP F D+H  L
Sbjct:  638 FPRGHLLFKEKLGEGQFGEVHLCEVVNPHELPTLQFPFNMRKGRSLLVAVKLLRADANKNARSDFLKELKILSRLSDPHIIRLLGACLDED-------------PLCMITEYMENGDLNQFLSSHHLDEGEESG--AQCLP--AISYPSLLHVAVQICSGMKYLSSLNFVHRDLASRNCLVGENFTIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDSKKQIFLFRPPPCPQPLYELMLQCWSRDCRERPSFQDIHALL 932          

Query:  516 HSQSGPDDGN-AWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNN--NQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAIL 998
            HS+   +DG+ AWCP   +    EE+++VD R +  +  + T GR  G   K +     ++Y R     +QWR+     NE +        + L+     IIA+ +R YP+      M  CL+    GC  +D   SY +P G+++++ ++  +L D  YDG  +
Sbjct:   63 HSRLESNDGDGAWCPLGPVFPNYEEFLQVDLRNLHFLTLVGTQGRDGGGLGKEFARHYQLRYSRDGFKWSQWRD--RWGNEVIEGNENTHDSVLKDLGPPIIARYVRFYPMAD--RVMSVCLRVELYGCIWQDGLRSYTSPPGNVMSLPSMLINLNDSTYDGFTV 223          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
             P   L+  +++  G+FG + +C ++   +  T    F           VK L  D+  + +S F+ +LKILS ++  ++++L    +D D                +I +Y+   +L  FL S +     +     Q +P   IS  SL+ +  Q+ +GMK+L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWEI  LC   PYG L++E ++    ++         L  P  CP+ +Y+LM +CW+ D   RP F D+H  L
Sbjct:  538 FPRGHLLFKEKLGEGQFGEVHLCEVVNPHELPTLQFPFNMRKGRSLLVAVKLLRADANKNARSDFLKELKILSRLSDPHIIRLLGACLDED-------------PLCMITEYMENGDLNQFLSSHHLDEGEESG--AQCLP--AISYPSLLHVAVQICSGMKYLSSLNFVHRDLASRNCLVGENFTIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDSKKQIFLFRPPPCPQPLYELMLQCWSRDCRERPSFQDIHALL 832          

Query:  516 HSQSGPDDGN-AWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNN--NQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQNGLGLLM-DNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDF------------KSITLYSVKD--FKHNIYLSGLITVTISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAK 1436
            HS+   +DG+ AWCP   +    EE+++VD R +  +  + T GR  G   K +     ++Y R     +QWR+     NE +        + L+     IIA+ +R YP+      M  CL+    GC  +D   SY +P G+++++ ++  +L D  YDG  +G LQ G    + D +   + F             + GW  ++  K  ++ + F F+  R F              I ++   D  FK +++         +  D   V+L+  +   D  A  + + +Q   ++   C    +   + ++LLSEI   S K
Sbjct:   62 HSRLESNDGDGAWCPLGPVFPNYEEFLQVDLRNLHFLTLVGTQGRDGGGLGKEFARHYQLRYSRDGFKWSQWRD--RWGNEVIEGNENTHDSVLKDLGPPIIARYVRFYPMAD--RVMSVCLRVELYGCIWQDGLRSYTSPPGNVMSLPSMLINLNDSTYDGFTVGGLQYGGLGQLTDGVIGADDFLQHKEQGVWPGYDYVGWMTSNFPKG-YLEMEFEFDALRSFIYMRVHCNNMGSGGIQIFRRVDCYFKRSLH---------TPWDPQPVTLSLALDVRDPSARSVTIALQGRAARILRCHYYFS---SQWLLLSEISFLSGK 370          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
             P   L+  +++  G+FG + +C ++   +  T    F           VK L  D+  + +S F+ +LKILS ++  ++++L    +D D                +I +Y+   +L  FL S +     +     Q +P   IS  SL+ +  Q+ +GMK+L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWEI  LC   PYG L++E ++    ++         L  P  CP+ +Y+LM +CW+ D   RP F D+H  L
Sbjct:  557 FPRGHLLFKEKLGEGQFGEVHLCEVVNPHELPTLQFPFNMRKGRSLLVAVKLLRADANKNARSDFLKELKILSRLSDPHIIRLLGACLDED-------------PLCMITEYMENGDLNQFLSSHHLDEGEESG--AQCLP--AISYPSLLHVAVQICSGMKYLSSLNFVHRDLASRNCLVGENFTIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDSKKQIFLFRPPPCPQPLYELMLQCWSRDCRERPSFQDIHALL 851          

Query:  516 HSQSGPDDGN-AWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNN--NQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQNGLGLLM-DNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDF------------KSITLYSVKD--FKHNIYLSGLITVTISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAK 1436
            HS+   +DG+ AWCP   +    EE+++VD R +  +  + T GR  G   K +     ++Y R     +QWR+     NE +        + L+     IIA+ +R YP+      M  CL+    GC  +D   SY +P G+++++ ++  +L D  YDG  +G LQ G    + D +   + F             + GW  ++  K  ++ + F F+  R F              I ++   D  FK +++         +  D   V+L+  +   D  A  + + +Q   ++   C    +   + ++LLSEI   S K
Sbjct:   58 HSRLESNDGDGAWCPLGPVFPNYEEFLQVDLRNLHFLTLVGTQGRDGGGLGKEFARHYQLRYSRDGFKWSQWRD--RWGNEVIEGNENTHDSVLKDLGPPIIARYVRFYPMAD--RVMSVCLRVELYGCIWQDGLRSYTSPPGNVMSLPSMLINLNDSTYDGFTVGGLQYGGLGQLTDGVIGADDFLQHKEQGVWPGYDYVGWMTSNFPKG-YLEMEFEFDALRSFIYMRVHCNNMGSGGIQIFRRVDCYFKRSLH---------TPWDPQPVTLSLALDVRDPSARSVTIALQGRAARILRCHYYFS---SQWLLLSEISFLSGK 366          

Query: 2325 VIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            V+    +I  +++ +G FG   V +  +  D+   A   VK+        +K  F+M+ +IL   +  N+VKL  I V +    I           YI+M+ + G + + FLR     N     K+ + +            +    A GM++LE     HRDLA RNC++  +  +KI   G+   + +  Y S   +  +   P++W APE++  G ++++SD+WSF V LWE F+L S VPY +++N+   +++       RL  P NCP ++Y LM RCW +D   RP F+ VH+ L
Sbjct:  555 VLEHEEVILGERIGKGNFG--EVFSGRLRADNTPVA---VKSCRDTLPPDLKDKFLMEARILKQYSHPNIVKL--IGVCTQKHPI-----------YIVMELVQGGDFQTFLR-----NEGPKLKVKELI-----------RMSENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDGVYSSTGGMKQI---PVKWTAPEALNYGRYSSESDVWSFGVLLWEAFSLGS-VPYATMSNQQTREIIE---QGIRLLVPDNCPDEVYSLMLRCWEYDPKKRPNFSTVHQEL 814          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            P  ++ +S  +    P +SL PI  + + EFG + +       +  T     VK+L    +      F  ++++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     ++D KL +S P S     +L   +   A GM+HL      H+DLA RNC+I  +  VK+   GL     N +Y            PLRWM+PE+++ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW  +   RP F+++   L    ++S
Sbjct:  769 PATNKRHSAGDRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLD-FRREVEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----NKDEKL-KSQPLSTKQKVALCSQV---ALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGDSPADS 1060          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSN-VSQDFKL-TQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   +          VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N  +Q     T+S     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP FA +H+FL
Sbjct:  562 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 866          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ +   L D  YDG    G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQS-FPTGYVEMEFEFDRLRTFQTMQVH 288          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSN-VSQDFKL-TQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   +          VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N  +Q     T+S     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP FA +H+FL
Sbjct:  599 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 903          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ +   L D  YDG    G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQS-FPTGYVEMEFEFDRLRTFQTMQVH 288          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSN-VSQDFKL-TQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   +          VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N  +Q     T+S     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP FA +H+FL
Sbjct:  599 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 903          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ +   L D  YDG    G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQS-FPTGYVEMEFEFDRLRTFQTMQVH 288          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSN-VSQDFKL-TQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   +          VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N  +Q     T+S     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP FA +H+FL
Sbjct:  599 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 903          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ +   L D  YDG    G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQS-FPTGYVEMEFEFDRLRTFQTMQVH 288          

Query: 2295 DQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM--LIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            ++ +S S+    P SSL PI  + + EFG + +     L EG  +T     VK+L    +      F  +L++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     S+D KL +S P S     +L   +   A GM+HL      H+DLA RNC++  +  VK+   GL     N +Y            PLRWM+PE+I+ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW      RP F+++   L   T +S
Sbjct:  780 NKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV--LVKSLQSKDEQQQLD-FRRELEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----SKDEKL-KSQPLSTKQKVALCTQV---ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1068          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            P  ++ +S  +    P +SL PI  + + EFG + +       +  T     VK+L    +      F  ++++   +N +N+V+L  +  +++               Y++++Y++  +LK FLR +     ++D KL +S P S     +L   +   A GM+HL      H+DLA RNC+I  +  VK+   GL     N +Y            PLRWM+PE+++ G F+TKSD+W+F V +WE+FT   +   G   +E L DL + +    RLP P+ CP  +Y LM RCW  +   RP F+++   L    ++S
Sbjct:  769 PATNKRHSAGDRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLD-FRREVEMFGKLNHANVVRLLGLCREAEP-------------HYMVLEYVDLGDLKQFLRISK----NKDEKL-KSQPLSTKQKVALCSQV---ALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHF----RQAWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA---RLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGDSPADS 1060          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXX-------XXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   + +        VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N     K+TQ +P  + S             +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP F+ +H+FL
Sbjct:  598 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDLNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSAHQLEN-----KVTQGLPGDRESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFSQLHRFL 902          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLR-TIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDP--FIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ + + L D  YDG    G    GLG L D +   + F     +       + GW   S H  P  ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEMVY-LNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGW---SNHSFPSGYVEMEFEFDRLRSFQTMQVH 287          

Query: 2286 PRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSN-VSQDFKL-TQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            PRVD           P S L   +++  G+FG + +C +     L+  D   +          VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    N  +Q     T+S     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP FA +H+FL
Sbjct:  599 PRVD----------FPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 903          

Query:  492 SAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            +AAR   + S  G  DG AWCP   +  K EE+++VD RR+ ++  + T GR  G   K ++    ++Y R +  +W ++ +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++ +   L D  YDG    G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   58 TAARHSRLESSDG--DG-AWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQS-FPTGYVEMEFEFDRLRTFQTMQVH 288          

Query: 2307 SDSNIRV-IPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR------YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLT--QSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNST 3251
             D   RV  P S L   +++  G+FG + +C +     L+  D     R        VK L  D+  + ++ F+ ++KI+S +   N+++L  + V  D                +I DY+   +L  FL +    + + +      Q+     IS   L+ +  Q+A+GM++L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+  LC   P+G LT+E ++    +    +     L  P  CP+ +Y+LM RCW+ +   RP F+ +H+FL     N+ 
Sbjct:  593 GDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP-------------LCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 909          

Query:  516 HSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQK-YTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNL-RTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDG-AILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLY 1196
            HS  G  DG AWCP  ++  K EE+++VD +R+ ++  + T GR  G   K ++    ++Y R +  +W  + +   + V++ N D    +  +L   ++A+ +R YP       M  CL+    GC   D  +SY AP G  + ++   + L D  YDG  + G    GLG L D +   + F     +       + GWS  S     ++ + F F++ R F+++ ++
Sbjct:   61 HSSDG--DG-AWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYP--RADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVY-LNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHS-FSSGYVEMEFEFDRLRAFQAMQVH 282          

Query:  318 WI--LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLM-SPKYLTDDQFSASSF---EYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIA--------NISFDLRDYIYDGAILGT---LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKI-FTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            WI  LF +  +   ++  KA Q   R    +  C   L+ S     D  FS+SS       FQP  ARL EV+  S    G AWCPN ++     EWI+ +F  +VII  I+T GR DGN ++Y P  +++Y+R +N  W  +V  +   VL  N D R   R+ L + +IAKRIRIYP  S  S  + CL+FA  GC   D  +SY  PQGD++T          +I    +D  YDG ++ +   L  G+G LMDN+A+       ++ +  +    F GW   S+     + I F F++ R+F  + +++
Sbjct:    8 WITLLFILCSFILTVNTYKAEQIIRRGPGQDPQCADPLINSIDTFPDTSFSSSSVWKNATDFQPFRARLTEVYGSSEHTSGYAWCPNTHVEDGLREWIQAEFSHLVIISVIFTAGRGDGNVKEYMPNFVLRYQREDNGVWYEHVKSDGTRVLKANNDPRNIARTTLDSVVIAKRIRIYPY-SHRSKQQVCLRFALYGCDFPDGVISYSMPQGDIVTYGRQLFGSPYSIPQSFQDLTYDGQLIESENQLIGGIGQLMDNVAYLGNVSQHSDSHPTQPGFHFIGWHIPSKD----LRILFKFDEVRNFIWLRIFT 315          

Query:  315 FWILFFIVIYNCL-------ISAVKAFQESVRFSDNETNCISYLM-SPKYLTDDQFSASSF---EYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLIT-----------IANISFDLRDYIYDGAILGT---LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKI-FTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTIS 1256
             +IL ++ IY  L       I   K  +   R    ++ C+S L+ S +   D  FSASS      +FQP  ARL +V+       G+AWCPN  I     EWI+ +F  +V+I  I+T GR DGN +++ P  ++KY+R +N  W  +V  +   VL  N+D R   R+ L + +IAKRIRIYP  S     + CL+FA LGC   D  VSY  PQG   +           I + S + RD  YDG ++GT   L +G+G LMDN+A+         +   K    F GW    +H    + I F F+  R F  + L++         L   ++V  S
Sbjct:    1 MYILSYLRIYFLLNALRFGTIQCSKNVRTVRRGLGPDSQCMSPLIKSHEEFPDSAFSASSTLEDRTEFQPHQARLPDVYGSKEHTSGHAWCPNTPIEESLREWIQAEFSDLVMIGAIFTAGRGDGNVKEFMPNFVLKYQREDNGPWYEHVKRDGTRVLRANSDPRNLARATLDSMVIAKRIRIYPY-SRDGKQQVCLRFALLGCKFPDGVVSYGMPQGGDRSYSTSPVPLGNPIGSFSANFRDLSYDGQLVGTNDHLTDGMGQLMDNVAYLGNVTTPLAMYPSKPGFHFVGW---YQHGQTDVPIVFKFDTARTFTWVRLFTFDSIPLRARLFSRVSVAFS 337          

Query:  315 FWILFFIVIYNCL-------ISAVKAFQESVRFSDNETNCISYLM-SPKYLTDDQFSASSF---EYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLIT-----------IANISFDLRDYIYDGAILGT---LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKI-FTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTIS 1256
             +IL ++ IY  L       I   K  +   R    ++ C+S L+ S +   D  FSASS      +FQP  ARL +V+       G+AWCPN  I     EWI+ +F  +V+I  I+T GR DGN +++ P  ++KY+R +N  W  +V  +   VL  N+D R   R+ L + +IAKRIRIYP  S     + CL+FA LGC   D  VSY  PQG   +           I + S + RD  YDG ++GT   L +G+G LMDN+A+         +   K    F GW    +H    + I F F+  R F  + L++         L   ++V  S
Sbjct:    1 MYILSYLRIYVLLNALRFGAIQCSKNVRTVRRGLGPDSQCMSPLIKSHEEFPDSAFSASSTLEDRTEFQPYQARLPDVYGSKEHTSGHAWCPNTPIEESLREWIQAEFSDLVMIGAIFTAGRGDGNVKEFMPNFVLKYQREDNGPWYEHVKRDGTRVLRANSDPRNLARATLDSMVIAKRIRIYPY-SRDGKQQVCLRFALLGCKFPDGVVSYGMPQGGDRSFSTNPVPLGNPIGSFSANFRDLSYDGQLVGTNDHLTDGMGQLMDNVAYLGNVTTPLAMYPSKPGFHFVGW---YQHGQTDVPIVFKFDTARTFTWVRLFTFDSIPLRARLFSRVSVAFS 337          

Query:  315 FWI-LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSP-KYLTDDQFSASSF---EYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIAN-------------ISFDLRDYIYDGAILGT---LQNGLGLLMDNIAWRNKF----DLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS-------VKDFKHNIYLSGLITVTISD 1259
            +WI ++  ++ +    + K  Q   R   ++ +C+S L+S      D  FSASS    +  FQP  ARL +V+       G AWCPN  +     EWI+ +F  +VIIK I+T GR DGN +++ P  ++KY+R +   W  +V  +   +L  N+D R   R+ L + +IAKR+RIYP  S   S   CL+FA  GC   D  VSY  PQG L T  +             ++  L+D  YDG I+ T   L +GLG LMDN+A+        DL+ +  G     F GW    + +   I + F F+  R F  I L++       V+ F H +    +   T SD
Sbjct:    7 YWINVWVAILMSGFAQSFKPEQIVRRGPGSDLHCMSPLISAYDEFPDSAFSASSVLQNKTDFQPYQARLTDVYGSKEHTSGYAWCPNSMVDEMLREWIQAEFSDLVIIKSIFTAGRGDGNVKEFMPSFVLKYQREDGGTWYEHVKRDGARILKANSDPRNLARATLDSVVIAKRVRIYPY-SRKGSRDVCLRFALYGCKFPDGVVSYTIPQGGLRTQTSFRSPALGDPLEPVVARHLKDLSYDGQIIPTTYQLTDGLGQLMDNVAFLGNLTRESDLYPSQPGFH---FVGWPQGEQSE---IQLIFKFDTTRRFTWIRLFTFDSLILRVRLFSHAMVAFSMNGSTFSD 347          

Query:  315 FWI-LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSP-KYLTDDQFSASSF---EYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIAN-------------ISFDLRDYIYDGAILGT---LQNGLGLLMDNIAWRNKF----DLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS-------VKDFKHNIYLSGLITVTISD 1259
            +WI ++  ++ +    + K  Q   R   ++ +C+S L+S      D  FSASS    +  FQP  ARL +V+       G AWCPN  +     EWI+ +F  +VIIK I+T GR DGN +++ P  ++KY+R +   W  +V  +   +L  N+D R   R+ L + +IAKR+RIYP  S   S   CL+FA  GC   D  VSY  PQG L T  +             ++  L+D  YDG I+ T   L +GLG LMDN+A+        DL+ +  G     F GW    + +   I + F F+  R F  I L++       V+ F H +    +   T SD
Sbjct:    7 YWINVWVAILMSGFAQSFKPEQIVRRGPGSDLHCMSPLISAYDEFPDSAFSASSVLQNKTDFQPYQARLTDVYGSKEHTSGYAWCPNSMVDEMLREWIQAEFSDLVIIKSIFTAGRGDGNVKEFMPSFVLKYQREDGGTWYEHVKRDGARILKANSDPRNLARATLDSVVIAKRVRIYPY-SRKGSRDVCLRFALYGCKFPDGVVSYTIPQGGLRTQTSFRSPALGDPLEPVVARHLKDLSYDGQIIPTTYQLTDGLGQLMDNVAFLGNLTRESDLYPSQPGFH---FVGWPQGEQSE---IQLIFKFDTTRRFTWIRLFTFDSLILRVRLFSHAMVAFSMNGSTFSD 347          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCT------MLIEG-----DHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSH--RNNTPRL--PCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            Y  P   VD     D ++   P   LI  +++  G+FG + +C        L EG         +    VK L  D+ S+ ++ F+ ++KI+S +N  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +S++ L+ +  Q+A+GMK+L  L   HRDLA RNC++D ++ +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC+  PY  LT+E +++      RN   ++    P  CP  +Y+LM RCW+ D   RP F+ +++ L+    +S
Sbjct:  507 YSVPAVTVDSLTRKDISVAEFPRERLIFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRSVLVAVKQLRADATSNARNDFLKEIKIMSRLNDPNIIRLLCVCVRSD-------------PLCMVTEYMENGDLNMFL-----SQRELESTLTHANNIPSVSMADLLHMAVQIASGMKYLASLNFVHRDLATRNCLLDRQLTIKISDFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCTEQPYSLLTDEQVIENSGEFFRNQGRQIYLSPPPLCPPSLYELMMRCWSRDIRDRPSFSSLYQALRPHAHHS 827          

Query:  426 MSPKYLTDDQFSASSFEYKFQ-PSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFD-LRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDP----FIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVT-----ISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSA 1433
            M    + +D  +ASS  Y+   P   RL   + + G  DG AWCP   +     ++++VD R++  +  + T GR A  +  ++  +  + Y R + ++W ++ N     ++  N                       +N+ AS           GC  +D   +Y AP+G  +         L D  YDG +    L  GLG L D +  ++ F     V   + +++ G+       D     ++ + F F+++R+F S+ ++    F   + +   ++       IS+ +   V  +  +   D + +   VTV L    G           + +++ SEI   SA
Sbjct:   28 MEDGRIKNDDITASSQWYETTGPQYGRL---NKEEG--DG-AWCPAGQLQPSDVQYLQVDLRQLTFVTVVATQGRYARSSGNEFARKYRLDYSR-DGHRWISWRNRYGSEIIKGN-----------------------VNTYAS--------VVFGCPWQDGLTAYSAPEGQTMMAPGFPNTLLNDSTYDGVLERRKLLGGLGQLTDGVIGQDDF-----VQTRQYQLWPGYDYLGWRNDSLGPGYVEMEFQFDRQRNFTSMKVHCNNMFSRGVKVFSSVSCVFKPHLISEWEAEPVVFSTVL--DDRNPSARYVTVPLLQRSGTATRCRFFFA-DTWMMFSEISFHSA 330          

Query: 2310 DSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGDHQTTAR----YFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            D  +   P   L   +++  G+FG + +C        ++ D            VK L  D+  + ++ F+ +++I+S +   N+++L  + V+SD                +I +Y+   +L  FL      +  ++ K T S     IS S+L+ + TQ+A+GMK+L  L   HRDLA RNC++     +KI   G+       DY  ++        P+RWM+ ESI+ G FT  SD+W+F VTLWE  TLC   PY  L+++ ++    +    +N    LP P  CP  ++ LM  CW  +   RP F  +H  L
Sbjct:  546 DGALEEFPREKLTFKEKLGEGQFGEVHLCEANGMQDFMKEDEDGVENEPILVAVKTLREDATKNTRNDFLKEIRIMSRLRDPNIIRLLAVCVESD-------------PLCMITEYMENGDLNKFLSRHKLQDSGEEQKDTSS----TISYSTLIRMATQIASGMKYLSSLNFVHRDLATRNCLVGTNYTIKIADFGMSRNLYRGDYYRIQ---GRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWETLTLCKEQPYSQLSDDQVIENTGEFFRDQNKQVYLPRPACCPDAVHSLMQSCWRRNAKERPSFQHIHSTL 844          

Query:  318 WILFFIVIYNCLISAVKAFQESVRFSDNETNCISYL-MSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGN-AWCPNKNIHSKP-EEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITV--------TISDRDNNQVSLNATIAGGDSDANELLVTVQLNH--SKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKR--PAIH 1487
            W +F +++   + S V           N   C   L M+   + D+  SASS     + +AAR    + +   DDG+ AWCP+    +K  +E++++D R +  +  + T GR ADG   ++     IKY R +  +W ++ + N   V+  N +    +  +L   IIA+ +R  P++    SM  C++    GC   D  VSY AP G  +T  N+   L D +YDG +  ++  GLG L D     + F             + GW+ AS       ++ F F++ R+F S+ ++      +N+Y SG+           + SD +   VS        ++ A    VTV L H  +    C    +   + +++ SEI  +S  ++  N +  P KR  P+ H
Sbjct:    6 WHIFLVILSGAVRSQV-----------NPGVCRYPLGMTGGKIQDEDISASS--QWSESTAAR----YGRLDFDDGDGAWCPDVVAEAKSLKEFLQIDLRTLHFVTLVGTQGRHADGMGNEFAQSYRIKYSR-DGVRWVSWHDRNGGQVIDGNKNPYEVVLKDLEPPIIARFVRFMPVSD--PSMTVCMRVELYGCEWLDGLVSYSAPVGQEMTFQNLHVYLNDTVYDGTVDHSMTEGLGQLTDGSWGLDNFTQSQVYGVWPGYDYVGWTNASFPSGSVEMV-FEFDRVRNFTSMKVHC-----NNMYTSGVRAFQQAVCYFRSESDWEARPVSFKPEADNTNTSAR--FVTVALGHRMASAIKCRFAFS---DAWMMFSEIAFQSGTAV-YNTSLIPRKRGHPSAH 380          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVI-------DLRM---HVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSN 3245
            +P   LI  +++  G+FG + +C +    D       F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +     T ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++       + RM   H+KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY  +T+E ++D              L  P  CP+ +Y+LM  CWN D   RP F  +H FL     N
Sbjct:  681 LPRERLIFKEKLGEGQFGEVHLCEIENPQDLPNLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRLLGVCVSSD-------------PLCMVTEYMESGDLNQYLSQRVLLDKTGPLHNTPTISYPALISMASQI-----ASGMKFLASLNFVHRDLATRNCLVGGERGDGEDRMGERHIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDHGRQIYLTRPAVCPQGLYELMLSCWNRDCKLRPSFTHMHSFLAEDAMN 990          

Query:  525 SGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            +G  DG AWCP   +     E+++V+  ++  +  + T GR ADG+ +++     ++Y R +  QW  + +   + V++ N +    +  +L   IIA+ +R YP+      M  CL+    GC   D   +Y AP G ++ ++     L D IYDG+I  GTL  GLG L D +   + F     +       + GWS  +  + P + I FHFE+ R F  + ++S
Sbjct:   89 TGEGDG-AWCPAGAVFPSGSEFLQVNLHKLHFLSLVGTQGRHADGHGREFARSYRLRYSR-DGRQWITWKDRWGQEVISGNENTYDVVLKDLGPPIIARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYAAPMGHVMHLSGSPIYLNDSIYDGSIEAGTLFGGLGQLCDGVLGGDDFMESKELRVWPGYDYVGWSREALGQ-PTVDIEFHFEKTRIFHVMQVHS 311          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVI-------DLRM---HVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSN 3245
            +P   LI  +++  G+FG + +C +    D       F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +     T ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++       + RM   H+KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY  +T+E ++D              L  P  CP+ +Y+LM  CWN D   RP F  +H FL     N
Sbjct:  662 LPRERLIFKEKLGEGQFGEVHLCEIENPQDLPNLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRLLGVCVSSD-------------PLCMVTEYMESGDLNQYLSQRVLLDKTGPLHNTPTISYPALISMASQI-----ASGMKFLASLNFVHRDLATRNCLVGGERGDGEDRMGERHIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDHGRQIYLTRPAVCPQGLYELMLSCWNRDCKLRPSFTHMHSFLAEDAMN 971          

Query:  525 SGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            +G  DG AWCP   +     E+++V+  ++  +  + T GR ADG+ +++     ++Y R +  QW  + +   + V++ N +    +  +L   IIA+ +R YP+      M  CL+    GC   D   +Y AP G ++ ++     L D IYDG+I  GTL  GLG L D +   + F     +       + GWS  +  + P + I FHFE+ R F  + ++S
Sbjct:   70 TGEGDG-AWCPAGAVFPSGSEFLQVNLHKLHFLSLVGTQGRHADGHGREFARSYRLRYSR-DGRQWITWKDRWGQEVISGNENTYDVVLKDLGPPIIARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYAAPMGHVMHLSGSPIYLNDSIYDGSIEAGTLFGGLGQLCDGVLGGDDFMESKELRVWPGYDYVGWSREALGQ-PTVDIEFHFEKTRIFHVMQVHS 292          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVI-------DLRM---HVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSN 3245
            +P   LI  +++  G+FG + +C +    D       F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +     T ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++       + RM   H+KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY  +T+E ++D              L  P  CP+ +Y+LM  CWN D   RP F  +H FL     N
Sbjct:  624 LPRERLIFKEKLGEGQFGEVHLCEIENPQDLPNLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRLLGVCVSSD-------------PLCMVTEYMESGDLNQYLSQRVLLDKTGPLHNTPTISYPALISMASQI-----ASGMKFLASLNFVHRDLATRNCLVGGERGDGEDRMGERHIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDHGRQIYLTRPAVCPQGLYELMLSCWNRDCKLRPSFTHMHSFLAEDAMN 933          

Query:  525 SGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            +G  DG AWCP   +     E+++V+  ++  +  + T GR ADG+ +++     ++Y R +  QW  + +   + V++ N +    +  +L   IIA+ +R YP+      M  CL+    GC   D   +Y AP G ++ ++     L D IYDG+I  GTL  GLG L D +   + F     +       + GWS  +  + P + I FHFE+ R F  + ++S
Sbjct:   70 TGEGDG-AWCPAGAVFPSGSEFLQVNLHKLHFLSLVGTQGRHADGHGREFARSYRLRYSR-DGRQWITWKDRWGQEVISGNENTYDVVLKDLGPPIIARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYAAPMGHVMHLSGSPIYLNDSIYDGSIEAGTLFGGLGQLCDGVLGGDDFMESKELRVWPGYDYVGWSREALGQ-PTVDIEFHFEKTRIFHVMQVHS 292          

Query: 2352 IQQVIRGEFGTI--SVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTY--YSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADV 3215
            ++++ +G FG +   +   +++G+ +T  R  +K +N  +    +  F+ +  ++ S NC ++V+L             L  V ++    +IM+ +   +LK +LRS      + ++   L +       SL  ++ +  ++A+GM +L      HRDLA RNC++     VKI   G+       DY        L   P+RWM+PES+  GVFTT SD+WSF V LWEI T     PY  L+NE +L  +    +   L  P  CP+ + +L+ +CW ++   RP F ++
Sbjct:   16 MRELGQGTFGMVYEGLARGIVKGEDET--RVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRL-------------LGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEDFTETIVLEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL---PVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAE-QPYQGLSNEQVLKFVM---DGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 285          

Query: 2352 IQQVIRGEFGTI--SVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADV 3215
            ++++ +G FG +   +   +++G+ +T  R  +K +N  +    +  F+ +  ++ S NC ++V+L             L  V ++    +IM+ +   +LK +LRS       +  +   S+P        ++ +  ++A+GM +L      HRDLA RNC++     VKI   G+       DY        L   P+RWM+PES+  GVFTT SD+WSF V LWEI T     PY  L+NE +L  +    +   L  P  CP+ + +L+ +CW ++   RP F ++
Sbjct:   64 MRELGQGTFGMVYEGLARGIVKGEDET--RVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRL-------------LGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLP-------EMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL---PVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAE-QPYQGLSNEQVLKFVM---DGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 324          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNSTSQAQIILPAP 3281
            A GM +L E    HRDLA RNC++  R+ VKI   GL  +    DY      N     P+RWM PESI    +T++SD+W+F V LWEIF+   L PY  +++E ++  +   N    L CP  CP D+Y+LM  CW    + RP FA V   L      +   AQ+  PAP
Sbjct:   94 AAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKA---NENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSH-GLQPYFGMSHEEVIYFVRDGN---VLACPDGCPLDLYNLMRLCWAHAPADRPSFASVQHVL------ARMHAQLTAPAP 252          

Query: 2487 FIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNST 3251
            F+M+ +IL   N  N+V+L  +               + T  YI+M+ + G +   FLR            + Q + YS+ +           A GM +LE     HRDLA RNC++     +KI   G+   + +  Y +  ++  +   P++W APE++  G +TT SD+WS+ + LWEIF+L S  PY   +N+   + ++   +  R+P P  CP  IY LM RCW +    RP F ++H+ L   T   T
Sbjct:  601 FLMEARILKRYNHPNVVRLIGVCT-------------RRTPVYIVMELVRGGDFLTFLRRE-----GSRLSVPQLLNYSEQA-----------AAGMAYLESHNCIHRDLAARNCLVGEASVLKISDFGMSRQQADGVYLATGVMRQI---PIKWTAPEALHYGTYTTMSDVWSYGILLWEIFSLGS-SPYPGWSNKMACEQVA---SGYRMPPPAVCPDGIYSLMLRCWEFHAEQRPTFTELHRELSLITRKHT 819          

Query: 2271 YHSPFPRVDQNNSDSNIRVIPISSLIPIQQVI-RGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYS-NVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADV----HKFLQFKTS-NSTSQAQIILPAP 3281
            Y  PF   D N +          S I I++VI  GE G +    + + G  Q  A   +K L        +  F+ +  I+      ++++LE +             V KS    II +++   +L  FLR      NV Q   + + +                 A GMK+L ++   HRDLA RN ++D ++  K+   GL  ++  ED        H    P+RW APE+I    FT+ SD+WSF V +WE+ +     PY  + N+   D++       RLP P +CP  ++ LM  CW  + + RP FA +     K LQ   S ++TSQ+ + L  P
Sbjct:  605 YVDPFTYEDPNKAVQEFAREIEPSWITIEKVIGSGESGEVCRGRLRVPG--QAEAPVAIKTLKAGYSEKQRRDFLSEASIMGQFEHPSIIRLEGV-------------VTKSKPVMIITEFMENGSLDAFLRGNDGQFNVGQLVGMLRGI-----------------AAGMKYLSDMNYIHRDLAARNVLVDSKLVCKVSDFGL--SRGLEDDPQAVYTTHGGKIPIRWTAPEAIAFRKFTSASDVWSFGVLMWEVMSYGER-PYWDMNNQ---DVIQAIEEGYRLPAPMDCPPALHQLMLDCWQKERTERPNFAQILAYLDKLLQNPASLHATSQSSVELSNP 910          

Query: 2769 NGMKHL-EELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLV-TF--PLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSL--TNEALLDLMSHRNN--TPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            NG+ HL  +  + HRD+   N +I+ +  +K+   G+          S +++N +  TF     +M+PE I   V++ K D+WS  + + E+ T     P G    T + +LDL+    N  +PRLP  +   K++ D +NRC   +E  R   + +H+ L
Sbjct:  316 NGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGV----------SKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVT--GEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERER---SSIHELL 461          

Query: 2559 DSDMSNIDLF---SVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVT--TKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFK 3236
            DS   NI  F    +I     ++IM+Y+ G  L D L +   SN  +      S P ++  ++ ++        G+K L    + HRD+   N +++ +  VKI   G     T+      +M      V  P  WMAPE +    +  K D+WS  + L E+       PY +      L L+++ N +P+L  P++  K     ++ C   +  +R   A V K L F+
Sbjct:  428 DSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGE-----HSSPLNENQMAYIVKET---CQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATM------VGTPY-WMAPEIVNQKGYDEKVDVWSLGIMLIEMIE--GEPPYLNEDPLKALYLIAN-NGSPKLRHPESVSKQTKQFLDACLQVNVESR---ASVRKLLTFE 637          

Query: 2772 GMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNSTSQAQIILPAPPPDDHT-S*FSWDSSLK 3329
            G+K+L   G+ HRD+   N ++     VK+   G V+T  N    ++          L WMAPE +     +T SDIWS   T+ E+ T     PY +LT+  +   + +    P    P +  + + D +++C+  +   RP  AD  + L+    NST   ++       +D T + + WD+  +
Sbjct:  133 GLKYLHGEGVIHRDIKAANILLSADNTVKLADFG-VSTIVNSSALTL-------AGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP--PYHNLTDANIYYAVENDTYYP----PSSFSEPLKDFLSKCFVKNMYKRPT-AD--QLLKHVWINSTENVKVDKLNKFKEDFTDADYHWDADFQ 302          

Query: 2610 FYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVT--TKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDL-MSHRNNTPRLPCPQNCPKDIYDLMNRC 3173
             +++M+++ G +L D + ++  ++ S        + Y                 G+K L +  + HRD+   N ++D R  VKI   G     T       +M      V  P  WMAPE +    +  K D+WS  +   E+  L    PY  L  + L  L +   N TP+L  P++   +I   ++ C
Sbjct:  636 LWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRET----------CQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATM------VGTPY-WMAPEVVKQREYDEKIDVWSLGIMTIEM--LEGEPPY--LNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVC 805          

Query: 2487 FIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFL--RSTYYSNVSQDFKLT-QSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD---LMSHRNNTPR---LPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNS 3248
            F  ++KI++ +   N+V+L  +  D  M               +I++Y+   +L  FL  R     N +   K+T Q++ Y  + L          A GMK++      HRDLA RNC++     VKI   G+     ++ Y  ++     V  P+RWMAPE I+ G FT+ SD+W+F VTLWEI TL +  PYG LT+E +++   LM  R  +     L  P+ CP D+Y  M  CW  + SARP F D+H FL+ + + S
Sbjct:   14 FFKEVKIMAGVRHENVVRLLGVCKDDPMC--------------MIVEYMENGDLNQFLKQRELASGNSADPNKVTYQALLYMALQL----------AAGMKYIASHQFVHRDLATRNCLVGHSFTVKIADFGMSRHLYSKHYYRIQ---GRVILPIRWMAPECILQGKFTSASDVWAFGVTLWEILTLAAEYPYGDLTDEKVIENVQLMFFRPKSDAITFLSRPEICPPDVYAKMRSCWAIEPSARPDFHDIHSFLENRVALS 249          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGD------HQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            +P   +  I+++  G FG      M+ EG+      ++   +  VK ++ ++    +  F+ +  I+ +  C+++V+L  +  D   +              ++M+ ++  +LK+FLRS          ++T        +L  ++ +  ++A+GM +L      HRDLA RNC+++  + VKI   G+       DY        L   P+RWMAPES+  GVFT+ SD+WSF V +WE+ TL S  PY   +NE +L  +      P+   P +CP  ++DLM  CW +   ARP F  +   ++
Sbjct:   13 VPREKIKLIRELGNGSFG------MVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPT-------------LVVMELMDNGDLKNFLRS-------HRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGLL---PVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQ-PYPGKSNEEVLKYVVDGGVMPK---PDDCPDRLFDLMTLCWQFSPKARPTFLSIISLIE 286          

Query: 2487 FIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL--QFKTSN 3245
            F+ +  ++  I   NLV+L             L    +   FYII +++   NL D+LRS       +D      M            + TQ+ + M +LE +   HRDLA RNC++     VK+   GL      + Y +    +    FP++W APE++    F+ KSD+W+F + LWE+ T   + PY  +    + D +   +   R+PCP+ CP ++Y LM  CW WD ++RP F ++H+ L   F +SN
Sbjct:   55 FLKEASVMKGIKHQNLVQL-------------LGVCTREPPFYIITEFMMNGNLLDYLRSP----KGKDLDAVTLM-----------YMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTA----HQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATY-GMSPYPGIDLSQVYDKL---DGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSN 273          

Query: 2610 FYIIMDYLNGYNLKDFL----------RSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGL---VTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNE-ALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
             +++++++ G +L+D L           S+ Y N+       Q +            +   +A GM HLEE    HRDLA RN ++ L +  K+   GL   VTT        + I++     P +WMAPES+  G++TTKSD+WSF V LWEI TL    PY    NE +++ L+ H  +  R+  P  C ++IY LM  CW  D + RP F ++ + L+
Sbjct:   30 LFVVIEFVEGGDLRDLLLKSRMSRNKWASSSYENLRSRLNERQLL-----------FLALGVARGMAHLEEKQCIHRDLAARNVLVGLGLVAKVADFGLARHVTTD------GLYIVSAQTKLPWKWMAPESL-RGLYTTKSDVWSFGVVLWEIATLGE-TPY---PNEVSIMKLLQHLIDGHRMSKPPYCDEEIYKLMLECWQLDPATRPSFKEIERTLK 228          

Query: 2442 VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWD 3185
            VK L     + +K+SF+ ++ +++ ++  N+V+L  ++ + +              + +I ++++  +L  ++R     ++ ++  LTQ           L+ I  Q+++GM+HL+ +   HRDLA RNC++   + VKI   G+       DY  +E        P+RWM PE+++ G FT +SD++SF V LWE++   +L PY   TNE +   +        L  P++CP  IYD+M  CWN D
Sbjct:    6 VKTLKQGCSNEMKTSFLQEVTLMAVLHHPNIVELLAVSTEEE-------------PYGMIFEFMSQGDLNQYMRKRGPYSLEEEKSLTQE---------DLLSISLQVSSGMEHLQSMRFVHRDLATRNCLVGDGLVVKIADFGMSRDVYASDYYKVE---GQAVMPIRWMPPEALLYGRFTVESDVYSFGVLLWEVYAF-ALQPYYGYTNEEVCGFI---KKGVHLGKPEDCPDHIYDVMKSCWNKD 224          

Query: 2304 NSDSNIRVIPISSLIPIQQVIRGEFGTISVCTM-----LIEGD------HQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIY-DLMNRCWNWDESARPKFADVHKFLQ 3230
             +DS++R  P   L   +++  G+FG + +C        ++ D       ++     VK L  D+  + ++ F+ +++I+S +   N+V+L  + VD+D               ++I +Y+   +L  FL      + S+ F L  ++ Y+++   ++ I     A+GMK+L  L   HRDLA RNC++     ++I   G+       DY  ++        P+RWM+ ESI+ G FT  SD+W+F VTLWEI TLC   PY  L++E ++    +    +     LP P  CP  +Y DLM  CW  +   RP F ++H  LQ
Sbjct:  540 GTDSSLREFPREKLSFKEKLGEGQFGEVHLCEAEGMQDFLDEDLSVGEISESLLLVAVKTLREDANKNARNDFLKEIRIMSRLRDPNIVRLLAVCVDTD-------------PLWMITEYMENGDLNQFL------SRSKIFFLFGALSYTKLINMAVQI-----ASGMKYLSSLNFVHRDLATRNCLVGKNYTIRIADFGMSRNLYKGDYYRIQ---GRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYSQLSDEQVIENTGEFFRDKGKQVYLPKPPCCPDSVYNDLMLSCWRRNAKQRPSFQEIHAQLQ 837          

Query:  354 ISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKP---EEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKI-FTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTI---SDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRP 1478
            IS    F E  R+           M+   + D+  SASS  Y  + +AA+   +    G  DG AWCP+  I S+P   +E+++VD R +  I  + T GR ADG   ++  +  IKY R  +N W ++ +   + V+  N +A   +  +L   IIA+ +R  P+     SM  C++    GC   D  VSY  P G  +   ++     D +YDGA   +L  GLG L D     + F L + + G      + GWS  +  K  ++ + F F+  R+F S+ +++   F   + +   +T      S+ +   ++   T       A  + VT+    +K   C  + +   + ++L SE+  +S  ++  N +  P K P
Sbjct:   23 ISVASCFPEVCRYPLG--------MTGGQIQDEDISASS--YWSESTAAKFGRLDIGGG--DG-AWCPD--IMSEPHGLKEYLQVDLRSLHFITLVGTQGRHADGMGNEFAQRYRIKYSRDGSN-WVSWQDRKGQQVIEGNRNAYDVVLKDLEPPIIARYVRFMPVTD--HSMIVCMRVELYGCEWLDGLVSYSIPDGHQMIYRDLEVSFNDSVYDGA---SLTKGLGQLTDGTWGLDDF-LHSQIYGVWPGYDYVGWSNRTFPKG-YVEMIFDFDHVRNFTSMKVHTSNMFSRGVRVFRQVTCFFWSDSEWEPGPITFRPTPDRVSQRARFVTVTLGDRTAKTIKCRFHFS---DVWMLFSEVAFQSGSAV-YNTSMGPGKHP 379          

Query: 2271 YHSPFPRVDQ-NNSDSNIRVIPISSLIPIQQVIRGEFGTISVCT------MLIEGD-----HQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALL----DLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ 3230
            Y  P   VD     D +    P   LI  +++  G+FG + +C        L EG              VK L  D+    ++ F+ ++KI+S ++  N+++L  + V SD                ++ +Y+   +L  FL     S    +  LT +     +SL  L+ +  Q+++GMK+L  L   HRDLA RNC++D R+ +KI   G+     + DY  ++        P+RWMA ESI+ G FTT SD+W+F VTLWEIFTLC   PY  L++E ++    +   ++     L  P  CP  +++LM RCW+ + + RP F  +++ L+
Sbjct:  516 YAVPALTVDSLTRKDISAAEFPRQQLIFREKLGEGQFGEVHLCEAEGLPEFLGEGSPLPDRDSRPVLVAVKQLRADATLQARNDFLKEIKIMSRLDDPNIIRLLCVCVSSD-------------PLCMVTEYMENGDLNMFL-----SQREIESTLTHANSIPSVSLCDLLHMAVQISSGMKYLASLNFVHRDLATRNCLVDRRLTIKIADFGMSRNLYSSDYYRIQ---GRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIENTGEFFRNQGRQIFLYSPPLCPPSLFELMMRCWSRNITDRPTFDGIYQTLR 830          

Query:  426 MSPKYLTDDQFSASSFEYKFQ-PSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLR-TIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANI-SFDLRDYIYDGAI-LGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDR---DNNQVSLNATIAGGDSDANELLVTVQLNH--SKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANS 1463
            M    + D   +ASS  Y+   P  ARL      +  D   AWCP   +     ++++VD   +  +  + T GR A G  +++     + Y R +   W+ + N    +V+  N +    +   L  +IIA+ +R+ P+  ++S++  C++    GC   D  +SY AP+G L+         L D IYDG      L  GLG L D +   + F L +         + GW   S+     + + F F+++R+F S+ ++S   F   + +   ++     R   +  Q ++       D + +   VTV LN   +K   C        + +++ SEI  +S +++  +   S
Sbjct:   29 MEDGRVKDKDITASSKWYETTGPQFARL------NREDGDGAWCPEGQLQHSDTQYLQVDLSVLTFLTLVGTQGRYARGLGKEFARAYRLNYSR-DGLTWKAWKNRQGNTVIEGNKNTYAIVYKELHPSIIARYVRLIPVTELSSTV--CMRVELYGCPWHDGLISYSAPEGQLMMPPGYPPASLNDSIYDGTHERRPLFGGLGQLTDGVVGMDDFLLTHEKQVWSGYDYLGWRNDSQGTQGHVEMEFVFDRQRNFTSMKVHSNNLFTRGVKIFSSVSCWFKPRLIANWEQEAVTFRTVLDDRNPSARYVTVPLNQRTAKALRCRFYFA---DVWMMFSEISFQSGENLHPDLKTS 372          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDL-----------RMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            +P   LI  +++  G+FG + +C +    D  +    F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +       ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++                +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY +LT+E ++D        +     L  P  CP+ +Y+LM  CWN D   RP FA +H FL
Sbjct:  648 LPRQCLIFKEKLGEGQFGEVHLCEIENPQDLPSLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIQLLGVCVSSD-------------PLCMVTEYMECGDLNQYLSHRVLLDKTGPSHNAPTISYPALISIASQI-----ASGMKFLSSLNFVHRDLATRNCLVGGDRGENGEDRGGERQIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSNLTDEQVIDNAGEFFRDQGRQVYLGKPAVCPQGLYELMLSCWNRDCKLRPSFAHIHSFL 952          

Query:  324 LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASS-FEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQ-NGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            LF + +   L   V A +    F  ++    +  M    + D   SASS +    +    RL      +G  DG AWCP   +     E++++D  ++  +  + T GR ADG+ Q++T    ++Y R +  +W  + +   + V++ NT+    +  +L   I+A+ +R YP+      M  CL+    GC   D   +Y +P G ++ +  +   L D IYDG+    +Q  GLG L D +   + F     +       + GWS  +  +   + I FHFE+ R F ++ ++S
Sbjct:    8 LFPVTVVTALAVLVSAEEHEWHFKPDQCR-YALGMEAGTIPDSDISASSAWSDSTEAKHGRL-----STGEGDG-AWCPLGPVFPSGSEYLQIDLHKLHFLALVGTQGRHADGHGQEFTRSYRLRYSR-DGVKWITWKDRWGQEVVSGNTNTHEVVLKDLGPPIVARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYTSPVGHVMNLPGLPVYLNDSIYDGSTEQRMQFGGLGQLCDGVLGGDDFTQTKELRVWPGYDYVGWSREALGQGS-VDIEFHFEKPRLFINMQVHS 292          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDL-----------RMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            +P   LI  +++  G+FG + +C +    D  +    F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +       ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++                +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY +LT+E ++D        +     L  P  CP+ +Y+LM  CWN D   RP FA +H FL
Sbjct:  688 LPRQCLIFKEKLGEGQFGEVHLCEIENPQDLPSLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIQLLGVCVSSD-------------PLCMVTEYMECGDLNQYLSHRVLLDKTGPSHNAPTISYPALISIASQI-----ASGMKFLSSLNFVHRDLATRNCLVGGDRGENGEDRGGERQIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSNLTDEQVIDNAGEFFRDQGRQVYLGKPAVCPQGLYELMLSCWNRDCKLRPSFAHIHSFL 992          

Query:  324 LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASS-FEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQ-NGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            LF + +   L   V A +    F  ++    +  M    + D   SASS +    +    RL      +G  DG AWCP   +     E++++D  ++  +  + T GR ADG+ Q++T    ++Y R +  +W  + +   + V++ NT+    +  +L   I+A+ +R YP+      M  CL+    GC   D   +Y +P G ++ +  +   L D IYDG+    +Q  GLG L D +   + F     +       + GWS  +  +   + I FHFE+ R F ++ ++S
Sbjct:    8 LFPVTVVTALAVLVSAEEHEWHFKPDQCR-YALGMEAGTIPDSDISASSAWSDSTEAKHGRL-----STGEGDG-AWCPLGPVFPSGSEYLQIDLHKLHFLALVGTQGRHADGHGQEFTRSYRLRYSR-DGVKWITWKDRWGQEVVSGNTNTHEVVLKDLGPPIVARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYTSPVGHVMNLPGLPVYLNDSIYDGSTEQRMQFGGLGQLCDGVLGGDDFTQTKELRVWPGYDYVGWSREALGQGS-VDIEFHFEKPRLFINMQVHS 292          

Query: 2328 IPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYF-----------VKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDL-----------RMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFL 3227
            +P   LI  +++  G+FG + +C +    D  +    F           VK L  D+  + ++ F+ ++KILS +   N+++L  + V SD                ++ +Y+   +L  +L      + +       ++ Y  +   +  I     A+GMK L  L   HRDLA RNC++                +KI   G+       DY  ++        P+RWMA E I+ G FTT SD+W+F VTLWE+ ++C   PY +LT+E ++D        +     L  P  CP+ +Y+LM  CWN D   RP FA +H FL
Sbjct:  688 LPRQCLIFKEKLGEGQFGEVHLCEIENPQDLPSLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIQLLGVCVSSD-------------PLCMVTEYMECGDLNQYLSHRVLLDKTGPSHNAPTISYPALISIASQI-----ASGMKFLSSLNFVHRDLATRNCLVGGDRGENGEDRGGERQIKIADFGMSRNLYAGDYYRIQ---GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSNLTDEQVIDNAGEFFRDQGRQVYLGKPAVCPQGLYELMLSCWNRDCKLRPSFAHIHSFL 992          

Query:  324 LFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASS-FEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGR-ADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQ-NGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYS 1199
            LF + +   L   V A +    F  ++    +  M    + D   SASS +    +    RL      +G  DG AWCP   +     E++++D  ++  +  + T GR ADG+ Q++T    ++Y R +  +W  + +   + V++ NT+    +  +L   I+A+ +R YP+      M  CL+    GC   D   +Y +P G ++ +  +   L D IYDG+    +Q  GLG L D +   + F     +       + GWS  +  +   + I FHFE+ R F ++ ++S
Sbjct:    8 LFPVTVVTALAVLVSAEEHEWHFKPDQCR-YALGMEAGTIPDSDISASSAWSDSTEAKHGRL-----STGEGDG-AWCPLGPVFPSGSEYLQIDLHKLHFLALVGTQGRHADGHGQEFTRSYRLRYSR-DGVKWITWKDRWGQEVVSGNTNTHEVVLKDLGPPIVARMVRFYPLAD--RVMSVCLRVELYGCVWNDGLKAYTSPVGHVMNLPGLPVYLNDSIYDGSTEQRMQFGGLGQLCDGVLGGDDFTQTKELRVWPGYDYVGWSREALGQGS-VDIEFHFEKPRLFINMQVHS 292          

Query:  300 MSLFGFWILFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAILGTLQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDRDNNQVSLNATIAGGDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAIHYFNTTDKYTTSLLSDKSESKISNWKQQDITXXXXXXXXXXXXXXXXXXXXXCYKLQRSRRSKLTKKLELVAQCNNQITRSQTPGTVFTIQSKTPANTTNQQPKYFSETKTTYSAAYSGSQPSDGVYASWPNTDEDPDLATIDKEEEKCLLSSEVGERSSMKEYATYQCSVNPTGANEYILTDNSLYRPKGNTRSSSIATTIPNISTLSVPLLKIVASYETPKTTPIVTFRSNKKLSSNNIESMCYQHLLNYRGSCGEVDFRYHSPFPRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNXXXXXXXXXXFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYXXXXXXXXXXXXXXXANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNSTSQAQIILPAPPPDDHTS 3302
            MSLFGFWILFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNN+QWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGA+LGTLQNGLGLLMDNIAWRNKFDLFNNVN EKEKIFTGWSC SRHK PFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDRDNNQVSLNATIAG DSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAIHYFNTTDKYTTSLLSDKSESKISNWKQQDITAMILVILIILLLIFVIAMAALCYKLQRSRRSKLTKKLELVAQCNNQ TRSQTPGTVFTIQSKTPANTTNQQPKYFSETKTTYSAAYSGSQPSDGVYASWPNTDEDPDLATIDKEEEKCLLSSEVGERSSMKEYATYQCSVNPTGANEYILTDNSLYRPKGNTRSSSIATTIPNISTLSVPLLKIVASYETPKTTPIVTFRSNKKLSSNNIESMCYQHLLNYRGSCGEVDFRYHSPFPRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNIDSKSSIKSSFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYSQISLSSLMIIITQLANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNSTSQAQIILPAPPPDDHTS
Sbjct:    1 MSLFGFWILFFIVIYNCLISAVKAFQESVRFSDNETNCISYLMSPKYLTDDQFSASSFEYKFQPSAARLIEVHSQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNDQWRNYVNLNNESVLTMNTDARTKLRSNLRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITIANISFDLRDYIYDGAVLGTLQNGLGLLMDNIAWRNKFDLFNNVNDEKEKIFTGWSCTSRHKYPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDRDNNQVSLNATIAGDDSDANELLVTVQLNHSKGYICSINITCGLNNFILLSEIEIKSAKSIRTNAANSPPKRPAIHYFNTTDKYTTSLLSDKSESKISNWKQQDITAMILVILIILLLIFVIAMAALCYKLQRSRRSKLTKKLELVAQCNNQSTRSQTPGTVFTIQSKTPANTTNQQPKYFSETKTTYSAAYSGSQPSDGVYASWPNTDEDPDLATIDKEEEKCLLSSEVGERSSMKEYATYQCSVNPTGANEYILTDNSLYRPKGNTRSSSIATTIPNISTLSVPLLKIVASYETPKTTPIVTFRSNKKLSSNNIESMCYQHLLNYRGSCGEVDFRYHSPFPRVDQNNSDSNIRVIPISSLIPIQQVIRGEFGTISVCTMLIEGDHQTTARYFVKNLNIDSKSSIKSSFIMDLKILSSINCSNLVKLETIAVDSDMSNIDLFSVIKSTRFYIIMDYLNGYNLKDFLRSTYYSNVSQDFKLTQSMPYSQISLSSLMIIITQLANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEILNHLVTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLDLMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSNSTSQAQIILPAPPPDDHTS 1001          

Query:  384 VRFSDNETNCISYLMSPKYLTDDQFSASS-FEYK--FQPSAARLIEVH-SQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSN-LRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLIT-IANISFDLRDYIYDGAILGT-----LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDRDNNQVSLNATIAGGDSDANE---LLVTVQLNHSKGYICSINI-TCGLNNFILLSEIEIKSA 1433
            VR S N  NC + LM    L DD+FSASS F+ +  FQ   ARL+ ++ S   P++GNAWCP+K   S   EWIEVDF+ + +I  I+T GR +GNF ++ P I I Y+R  N +   Y  + N+S++ +NTDART+ R+  +  IIA  I+IYP++   + M  C+KFA  GC   D  VSY    GD ++   ++     D  +DG  +       L+NGLGLL DN AW        ++ G ++  F GW  ++    P+I I F +E+ R+F  + ++S +     I +   + +        +  +   ++  +   N    ++ T+ L+H+ G +  + +    LN +IL+SEI   S+
Sbjct:   29 VRSSKN--NCWTSLMEITDLPDDRFSASSSFQNRSTFQAHQARLLYIYRSNPQPENGNAWCPHKKASSHFNEWIEVDFKSINVINGIFTKGRGEGNFVEFVPTIKIAYQRERNGRIYEYQTIENQSLIPINTDARTQSRTKFIPAIIASSIKIYPVDPYDAQM-ICIKFALFGCDFHDSPVSYSTFDGDNMSHHKSVGITTSDRYFDGDKIRQNSKILLKNGLGLLTDNRAW------LGSLEGLRDPYFLGWYVSNASPIPYIPISFEYEKRRNFTKLQIFSYQLPSQTIDIFSKVNLKFQSNTKLESEIEKDVSRANVQMNRFGGVIFTMLLSHNVGNMVKLQLHATNLNRWILVSEINFVSS 384          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKP-NEDYCSMEILNHL-VTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD-----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ------FKTSNSTSQAQI 3266
            A+GMKH+EE G+ HRDLACR+C++++ + VKI  GG   + P + DY S+ + ++  +  P+RWMAPES+    F++KSD+W+F VTLWE+ T C+  PY   +N  ++D     L++  +    L  P+ CPK+IYD++  CW+  E  RP F ++H FLQ      F T N  S+  I
Sbjct:  932 ASGMKHMEEQGILHRDLACRSCMVNMNLQVKITNGGHQISSPFDVDYLSIPLSDYTSIHLPIRWMAPESLFNAKFSSKSDVWAFGVTLWEVLTHCNQQPYYYWSNSQVMDNLYNILLAQNSQFHYLTRPKICPKEIYDMIRECWHPTEDYRPNFHEIHMFLQRKCIGYFNTENGFSRPMI 1111          

Query:  384 VRFSDNETNCISYLMSPKYLTDDQFSASS-FEYK--FQPSAARLIEVH-SQSGPDDGNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSN-LRTIIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLIT-IANISFDLRDYIYDGAILGT-----LQNGLGLLMDNIAWRNKFDLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNIYLSGLITVTISDRDNNQVSLNATIAGGDSDANE---LLVTVQLNHSKGYICSINI-TCGLNNFILLSEIEIKSA 1433
            VR S N  NC + LM    L DD+FSASS F+ +  FQ   ARL+ ++ S   P++GNAWCP+K   S   EWIEVDF+ + +I  I+T GR +GNF ++ P I I Y+R  N +   Y  + N+S++ +NTDART+ R+  +  IIA  I+IYP++   + M  C+KFA  GC   D  VSY    GD ++   ++     D  +DG  +       L+NGLGLL DN AW        ++ G ++  F GW  ++    P+I I F +E+ R+F  + ++S +     I +   + +        +  +   ++  +   N    ++ T+ L+H+ G +  + +    LN +IL+SEI   S+
Sbjct:   33 VRSSKN--NCWTSLMEITDLPDDRFSASSSFQNRSTFQAHQARLLYIYRSNPQPENGNAWCPHKKASSHFNEWIEVDFKSINVINGIFTKGRGEGNFVEFVPTIKIAYQRERNGRIYEYQTIENQSLIPINTDARTQSRTKFIPAIIASSIKIYPVDPYDAQM-ICIKFALFGCDFHDSPVSYSTFDGDNMSHHKSVGITTSDRYFDGDKIRQNSKILLKNGLGLLTDNRAW------LGSLEGLRDPYFLGWYVSNASPIPYIPISFEYEKRRNFTKLQIFSYQLPSQTIDIFSKVNLKFQSNTKLESEIEKDVSRANVQMNRFGGVIFTMLLSHNVGNMVKLQLHATNLNRWILVSEINFVSS 388          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKP-NEDYCSMEILNHL-VTFPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLTNEALLD-----LMSHRNNTPRLPCPQNCPKDIYDLMNRCWNWDESARPKFADVHKFLQ------FKTSNSTSQAQI 3266
            A+GMKH+EE G+ HRDLACR+C++++ + VKI  GG   + P + DY S+ + ++  +  P+RWMAPES+    F++KSD+W+F VTLWE+ T C+  PY   +N  ++D     L++  +    L  P+ CPK+IYD++  CW+  E  RP F ++H FLQ      F T N  S+  I
Sbjct:  936 ASGMKHMEEQGILHRDLACRSCMVNMNLQVKITNGGHQISSPFDVDYLSIPLSDYTSIHLPIRWMAPESLFNAKFSSKSDVWAFGVTLWEVLTHCNQQPYYYWSNSQVMDNLYNILLAQNSQFHYLTRPKICPKEIYDMIRECWHPTEDYRPNFHEIHMFLQRKCIGYFNTENGFSRPMI 1115          

Query:  441 LTDDQFSASSFE---YKFQPSAARLIEVHSQSGPDD----GNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITI--ANISFDLRDYIYDGAI-------LGTLQNGLGLLMDNIAWRNKF--DLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNI 1223
            L ++ F ASS      +F+P  AR+ ++      DD    G+AWCP + I S PEEWIE+D   + +IK + T GR DGNF +Y P   + Y+R  + +W  Y N   E +L  NTDAR    +N  + IIA+RIRIYPI S    ++AC++    GC  +D  V Y   QG   T    N  +DLRD  YDG I        G L+ GLG LMDN+ +      D  N + G     F GW+      +   I+   F+Q R  K I  Y++     +I
Sbjct:   54 LKNESFIASSVWKEIVEFEPHQARMKQM------DDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRV-SGKWIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPI-SKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYH---FVGWNRKFLDSNKVEIV-MKFDQMRSVKQIRFYAMNMIPEDI 321          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEIL----------NHLVT-----FPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLT-----------------------NEALLDLMSHRNNTP--RLPCPQNC--------PKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSN 3245
            A GM +LE   + HRDLA RNC+I   + +KI    +   K  E Y    ++          N  ++     +PL+WMA ESI+   ++ K+DIWSF VT+WEI   C   PYG                          NE L    S  N  P   +  P +          +D  DL+  CWN +   RP F  +   L+ K +N
Sbjct:  953 ARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYIECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNAYNLSIGNSSAVFPNENLYPHQSQSNFRPSQHMANPSSSILHEDLGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITN 1160          

Query:  441 LTDDQFSASSFE---YKFQPSAARLIEVHSQSGPDD----GNAWCPNKNIHSKPEEWIEVDFRRMVIIKRIYTMGRADGNFQKYTPQILIKYKRSNNNQWRNYVNLNNESVLTMNTDARTKLRSNLRT-IIAKRIRIYPINSIASSMKACLKFAFLGCFIEDDAVSYDAPQGDLITI--ANISFDLRDYIYDGAI-------LGTLQNGLGLLMDNIAWRNKF--DLFNNVNGEKEKIFTGWSCASRHKDPFIIIRFHFEQERDFKSITLYSVKDFKHNI 1223
            L ++ F ASS      +F+P  AR+ ++      DD    G+AWCP + I S PEEWIE+D   + +IK + T GR DGNF +Y P   + Y+R  + +W  Y N   E +L  NTDAR    +N  + IIA+RIRIYPI S    ++AC++    GC  +D  V Y   QG   T    N  +DLRD  YDG I        G L+ GLG LMDN+ +      D  N + G     F GW+      +   I+   F+Q R  K I  Y++     +I
Sbjct:   52 LKNESFIASSVWKEIVEFEPHQARMKQM------DDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRV-SGKWIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPI-SKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYH---FVGWNRKFLDSNKVEIV-MKFDQMRSVKQIRFYAMNMIPEDI 319          

Query: 2766 ANGMKHLEELGLTHRDLACRNCVIDLRMHVKIYPGGLVTTKPNEDYCSMEIL----------NHLVT-----FPLRWMAPESIIAGVFTTKSDIWSFAVTLWEIFTLCSLVPYGSLT-----------------------NEALLDLMSHRNNTP--RLPCPQNC--------PKDIYDLMNRCWNWDESARPKFADVHKFLQFKTSN 3245
            A GM +LE   + HRDLA RNC+I   + +KI    +   K  E Y    ++          N  ++     +PL+WMA ESI+   ++ K+DIWSF VT+WEI   C   PYG                          NE L    S  N  P   +  P +          +D  DL+  CWN +   RP F  +   L+ K +N
Sbjct:  951 ARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYIECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNAYNLSIGNSSAVFPNENLYPHQSQSNFRPSQHMANPSSSILHEDLGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITN 1158