SMED30000510

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEG++ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  +    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R    A   +S Q +S     E   S   PT P +  I      + K L   N G         D  ++    +  V   R    +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLIAG-AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEV---RQGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGED 734          

Query: 2439 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS------DYWLDLEPEGKLRISCILNGSKIEE-ISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWN-QGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYS-SSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDF 4649
            F+G + V+I EA  L+ T  + RH++    K  + LDPY+ V VD+  VG++STK K N P +++E   +VT G  +   V+H+  +  D F+A     F+ +  T+      + W+DLEPEGK+ +   L GS  E  + R+++          H    R  A+RRR+HQI GHKF  T  +Q T+CS C  FIWG++  QGYQCQVCTCVVHKRC+  ++  C    +     S+    RF IN+PHKF +H +  P FCDHCGSLL+G+MRQGLQC+ CK+N+H RC+ NVAP+CGVN  +L + +   GL P ++        + TS  ++ ST +                                    S    N  GV+ S  LG                          + +F F++VLGKGSFGKV+LA  K T D+YA+K+LKK+VILQD+DVECTMTE+RIL+LA  HPFLT L   FQT DRLFFVME+VNGGDLMF IQ+ RRFDE RA FY++E+  ALMFLH  GIIYRDLKLDN+LLD EGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E  YG +VDWWA+GVL+YEM+ G  PFE + E DLF AI  D V +P+ L   +  I+  F+ KNP  RLG +  +GG+ AI+RHPFF+EIDW  L  R+I PPFRP+++SR D SNFD DF  E+PVLTPI+    +  + +D F  F +
Sbjct:    8 FNGYLRVRIGEAVGLQPTRWSLRHSL--FKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDRIFK--------HFTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNI--------SPTSKLVSRSTLRRQGK-------------------------------ESSKEGNGIGVNSSNRLG--------------------------IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEG-HLPMINQDEFRNFSY 676          

Query: 2427 LRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWN-QGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYS-SSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4178
            +RRR+HQI GHKF  T  +Q T+CS C  FIWG++  QGYQCQVCTCVVHKRC+  ++  C    +     S+    RF IN+PHKF +H +  P FCDHCGSLL+G+MRQGLQC+ CK+N+H RC+ NVAP+CGVN  +L + +   GL P ++        + TS  ++ ST +                                    S    N  GV+ S  LG                          + +F F++VLGKGSFGKV+LA  K T D+YA+K+LKK+VILQD+DVECTMTE+RIL+LA  HPFLT L   FQT DRLFFVME+VNGGDLMF IQ+ RRFDE RA FY++E+  ALMFLH  GIIYRDLKLDN+LLD EGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E  YG +VDWWA+GVL+YEM+ G  PFE + E DLF AI  D V +P+ L   +  I+  F+ KNP  RLG +  +GG+ AI+RHPFF+EIDW  L  R+I PPFRP+++SR D SNFD DF  E+PVLTPI+    +  + +D F  F + + +
Sbjct:    1 MRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNI--------SPTSKLVSRSTLRRQGK-------------------------------ESSKEGNGIGVNSSNRLG--------------------------IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEG-HLPMINQDEFRNFSYVSPE 519          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            ++ WL+L+P+G++    ++N     E+S  K         GF   H R GA+++ ++H +K H+F  T F Q TFCS+C+ F+WGL  QGYQC+ C   +HK+C   VI +C G       +     RF I++PH+F+V+ +  P FC+HCG+LL+GL RQGL+C+AC +N+H RC+  VA  CG+N K + EA+                E T  +  + D+ Q   + P+                P +I+   +   L +       G+     L D   K      P   +E         + DF   K+LGKGSFGKV LAE K T   +AIK LKK+V+L D+DVECTM E+R+L+LA +HPFLT +  +FQT + LFFVMEY+NGGDLM+ IQ   +FD  RA FY++E+ L L FLH  GI+YRDLKLDNILLD +GH K+ADFGMCKE M G   T+TFCGTPDYIAPEIL  Q Y  SVDWW+ GVL+YEM+ G  PF G  E++LF++I  D+  +P  L+  + D++ K  ++ P KRLG       +  I +HP FREI+W  LE + I PPFRPKV+S  D SNFDK+F +E P L+   +   I ++ +++F  F F N
Sbjct:   67 TEIWLELKPQGRM----LMNARYFLEMSDTK-DMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEAL-------------AMIESTQQARCLRDTEQIFREGPVE------------IGLPCSIKNEARPPCLPTPGKREPQGISWESPL-DEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV------RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FADRALINSMDQNMFRNFSFMN 662          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            ++ WL+L+P+G++    ++N     E+S  K         GF   H R GA+++ ++H +K H+F  T F Q TFCS+C+ F+WGL  QGYQC+ C   +HK+C   VI +C G       +     RF I++PH+F+V+ +  P FC+HCG+LL+GL RQGL+C+AC +N+H RC+  VA  CG+N K + EA+                E T  +  + D+ Q   + P+                P +I+   +   L +       G+     L D   K      P   +E         + DF   K+LGKGSFGKV LAE K T   +AIK LKK+V+L D+DVECTM E+R+L+LA +HPFLT +  +FQT + LFFVMEY+NGGDLM+ IQ   +FD  RA FY++E+ L L FLH  GI+YRDLKLDNILLD +GH K+ADFGMCKE M G   T+TFCGTPDYIAPEIL  Q Y  SVDWW+ GVL+YEM+ G  PF G  E++LF++I  D+  +P  L+  + D++ K  ++ P KRLG       +  I +HP FREI+W  LE + I PPFRPKV+S  D SNFDK+F +E P L+   +   I ++ +++F  F F N
Sbjct:  103 TEIWLELKPQGRM----LMNARYFLEMSDTK-DMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEAL-------------AMIESTQQARCLRDTEQIFREGPVE------------IGLPCSIKNEARPPCLPTPGKREPQGISWESPL-DEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV------RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FADRALINSMDQNMFRNFSFMN 698          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTH-GCIITFTVYHXXXXXXXXXXXXXDKSFESIE--STSDYWLDLEPEGKLRISCILNGSKIEEI-SREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSS------SEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYE---RTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+G+V V+++EA++L+ T  + R      A     +D YV V+ DE  +GK+  + K N P+W++E +    H G  I F+V+H   +PPDDF+A    +F+ ++  S +D W+DLEP G+L +   ++G+ +E++ S  K     +    F+ +  R GA+RR+IH++ GHKF     +Q TFC+ C  FIWG+  QGYQCQ+CT VVHKRC+++V+ +CPG K            E    RFNIN+PH+F VH++ RP FCDHCGS+L+GL+ QGLQC  CKLN+HKRC++NVA +CG+N K +   + + GL    +    + +    T TS +I+ S+   +   + + S                                    DDS     RS+ +V     S             + DF F+KVLGKGSFGKV+LAE K T +VYAIKILKK+VI+QD+DVECTM E+RIL+LAAKHPFLTALHSSFQT DRLFFVMEYVNGGDLMFQIQR R+FDE RA FY++EVT AL FLH++ +IYRDLKLDNILLDAEGHC+LADFGMCKEG++   LTSTFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF AI  D V +P  L   +V+I+  F+ KN  KRLGCV  +GG+ AI  HPFFREIDW  LE R+++PPF+PK++S+ D +NFD DFT E+PVLTP + +  + A+ +D F GF F N  +
Sbjct:   59 FTGTVRVRVLEARQLRPTEWSRRFRQDEAAT--AAIDSYVNVDWDEYHIGKTQVRPKTNEPRWNEEFTASGVHQGKAIGFSVFHSCVMPPDDFVANTRIAFDQLKIGSANDIWVDLEPHGQLHVVVEMHGTNVEDVHSHNKTRVFKERTNAFNDRQ-RRGAMRRKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMSIRSKKKPSIMTDTSTDISGSSNSENSGYLQQIS-----------------------------------EDDSGTTSSRSASKVPGGTLS-------------IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAV-VRAINQDEFRGFSFINPHF 761          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTH-GCIITFTVYHXXXXXXXXXXXXXDKSFESIE--STSDYWLDLEPEGKLRISCILNGSKIEEI-SREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSS------SEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYE---RTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+G+V V+++EA++L+ T  + R      A     +D YV V+ DE  +GK+  + K N P+W++E +    H G  I F+V+H   +PPDDF+A    +F+ ++  S +D W+DLEP G+L +   ++G+ +E++ S  K     +    F+ +  R GA+RR+IH++ GHKF     +Q TFC+ C  FIWG+  QGYQCQ+CT VVHKRC+++V+ +CPG K            E    RFNIN+PH+F VH++ RP FCDHCGS+L+GL+ QGLQC  CKLN+HKRC++NVA +CG+N K +   + + GL    +    + +    T TS +I+ S+   +   + + S                                    DDS     RS+ +V     S             + DF F+KVLGKGSFGKV+LAE K T +VYAIKILKK+VI+QD+DVECTM E+RIL+LAAKHPFLTALHSSFQT DRLFFVMEYVNGGDLMFQIQR R+FDE RA FY++EVT AL FLH++ +IYRDLKLDNILLDAEGHC+LADFGMCKEG++   LTSTFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF AI  D V +P  L   +V+I+  F+ KN  KRLGCV  +GG+ AI  HPFFREIDW  LE R+++PPF+PK++S+ D +NFD DFT E+PVLTP + +  + A+ +D F GF F N  +
Sbjct:    3 FTGTVRVRVLEARQLRPTEWSRRFRQDEAAT--AAIDSYVNVDWDEYHIGKTQVRPKTNEPRWNEEFTASGVHQGKAIGFSVFHSCVMPPDDFVANTRIAFDQLKIGSANDIWVDLEPHGQLHVVVEMHGTNVEDVHSHNKTRVFKERTNAFNDRQ-RRGAMRRKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMSIRSKKKPSIMTDTSTDISGSSNSENSGYLQQIS-----------------------------------EDDSGTTSSRSASKVPGGTLS-------------IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAV-VRAINQDEFRGFSFINPHF 705          

Query: 2424 RAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSS------SEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYE---RTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4190
            R GA+RR+IH++ GHKF     +Q TFC+ C  FIWG+  QGYQCQ+CT VVHKRC+++V+ +CPG K            E    RFNIN+PH+F VH++ RP FCDHCGS+L+GL+ QGLQC  CKLN+HKRC++NVA +CG+N K +   + + GL    +    + +    T TS +I+ S+   +   + + S                                    DDS     RS+ +V     S             + DF F+KVLGKGSFGKV+LAE K T +VYAIKILKK+VI+QD+DVECTM E+RIL+LAAKHPFLTALHSSFQT DRLFFVMEYVNGGDLMFQIQR R+FDE RA FY++EVT AL FLH++ +IYRDLKLDNILLDAEGHC+LADFGMCKEG++   LTSTFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF AI  D V +P  L   +V+I+  F+ KN  KRLGCV  +GG+ AI  HPFFREIDW  LE R+++PPF+PK++S+ D +NFD DFT E+PVLTP + +  + A+ +D F GF F N  +
Sbjct:   70 RRGAMRRKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMSIRSKKKPSIMTDTSTDISGSSNSENSGYLQQIS-----------------------------------EDDSGTTSSRSASKVPGGTLS-------------IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAV-VRAINQDEFRGFSFINPHF 618          

Query: 2421 SREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEY-------GDTP-KVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSK-LTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYN 4250
            SR    PG Q          R GA++  R+H+I+GH+F  T F+Q  FCSLC+ F+WGL  QGYQCQ+C+  VHK+C++ VI++CPG       + A   RF +++PH+F+ + F  P FCDHCGS+L+GL +QGL+CE C +  H +CE+ ++                CG+N   L        +     I   T  ++  P                      P    L LN  ++ N   + + +    +S +  +  +  +  EY       GD P K   L  FN +KVLGKGSFGKV+L E K   + YA+K LKK+VIL+D+D ECT  E+R+L LA++ PFL  L  SFQT++ LFFVMEY+NGGDLM  IQ++++FDE R  FY+ E+ +AL FLH + IIYRDLKLDN+LLD +GH KLADFGM K  M+    + STFCGTPDYI+PEI+  Q Y  +VD+W+ GVLMYEM+ G  PF G+ E +LF++I  +   FP ++   +   +S    +NP  RLG      G   I +H FFR +DW   E R++ PPF+P ++S +D SNFD DFT+E   LTP+ +   +A++  + F  F + N  ++
Sbjct:    3 SRSNSGPGIQR---------RRGAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMS--------------NLCGVNQKQL--------SEMYHEIKRGTHATASCP----------------------PNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKET-DEYMDNIWGGGDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDG--PIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHFS 566          

Query: 2421 SREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEY-------GDTP-KVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSK-LTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYN 4250
            SR    PG Q          R GA++  R+H+I+GH+F  T F+Q  FCSLC+ F+WGL  QGYQCQ+C+  VHK+C++ VI++CPG       + A   RF +++PH+F+ + F  P FCDHCGS+L+GL +QGL+CE C +  H +CE+ ++                CG+N   L        +     I   T  ++  P                      P    L LN  ++ N   + + +    +S +  +  +  +  EY       GD P K   L  FN +KVLGKGSFGKV+L E K   + YA+K LKK+VIL+D+D ECT  E+R+L LA++ PFL  L  SFQT++ LFFVMEY+NGGDLM  IQ++++FDE R  FY+ E+ +AL FLH + IIYRDLKLDN+LLD +GH KLADFGM K  M+    + STFCGTPDYI+PEI+  Q Y  +VD+W+ GVLMYEM+ G  PF G+ E +LF++I  +   FP ++   +   +S    +NP  RLG      G   I +H FFR +DW   E R++ PPF+P ++S +D SNFD DFT+E   LTP+ +   +A++  + F  F + N  ++
Sbjct:    3 SRSNSGPGIQR---------RRGAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMS--------------NLCGVNQKQL--------SEMYHEIKRGTHATASCP----------------------PNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKET-DEYMDNIWGGGDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDG--PIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHFS 566          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENL-DPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI----ESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAG------ALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEA--QLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS-------------TQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+G + +K+ EA  L+ T    RH +       E L DPYV ++VDE    +++T+ K  +P W+++   DVT+   I  TV+HDAA+PPDDF+A    SFE +     +  D W++LEP+GK+ +   L  ++ ++   E +   T ++     +  RAG      A+RRR+HQ+ GHKF  T  +Q TFCS C  FIWG+  QGYQCQVCT VVHK+C+ +V+ +CPG++D  +  E      RFN+N+PH+F VH++ R  FCDHCGSLL+GL++QGLQCE C +N+HKRC+KNVA  CG+NTK + E +   G++P      PR  +        D+              Q      +   SL++   T    Y              + S+C    V  S  +G     R               P    L DFNF+KVLGKGSFGKV+LAE K T ++YAIK+LKK+ I+QD+DV+CTMTE+RILALAA HPFLTALHS FQT DRLFFVMEYVNGGDLMFQIQ+ RRF+  RA FY++EVTLAL FLH HG+IYRDLKLDNILLD EGHCKLADFGMCKEG+    LT+TFCGTPDYIAPEIL EQ+YG SVDWWALGVLMYEMMAG PPFE D E +LF++I +D V +P  L   +V I+  FL KNP +RLGC    G +  I +HPFF ++DW  LE+R I+PPFRPK+++  D +NFD +FT EDPVLTPI N   +  + +D FAGF F N  +
Sbjct:    2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIELK-NRTDKAKAEAVVEHTVAVNKEFKE--RAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK--QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGY--------------NSSSCMSLAVTGSGGVGATGETR---------------PGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEV-VRCINQDEFAGFSFVNPKF 731          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENL-DPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI----ESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAG------ALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL---NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS-------------TQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+G + +K+ EA  L+ T    RH +       E L DPYV ++VDE    +++T+ K  +P W+++   DVT+   I  TV+HDAA+PPDDF+A    SFE +     +  D W++LEP+GK+ +   L  ++ ++   E +   T ++     +  RAG      A+RRR+HQ+ GHKF  T  +Q TFCS C  FIWG+  QGYQCQVCT VVHK+C+ +V+ +CPG++D   +    +    RFN+N+PH+F VH++ R  FCDHCGSLL+GL++QGLQCE C +N+HKRC+KNVA  CG+NTK + E +   G++P      PR  +        D+              Q      +   SL++   T    Y              + S+C    V  S  +G     R               P    L DFNF+KVLGKGSFGKV+LAE K T ++YAIK+LKK+ I+QD+DV+CTMTE+RILALAA HPFLTALHS FQT DRLFFVMEYVNGGDLMFQIQ+ RRF+  RA FY++EVTLAL FLH HG+IYRDLKLDNILLD EGHCKLADFGMCKEG+    LT+TFCGTPDYIAPEIL EQ+YG SVDWWALGVLMYEMMAG PPFE D E +LF++I +D V +P  L   +V I+  FL KNP +RLGC    G +  I +HPFF ++DW  LE+R I+PPFRPK+++  D +NFD +FT EDPVLTPI N   +  + +D FAGF F N  +
Sbjct:    2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIELK-NRTDKAKAEAVVEHTVAVNKEFKE--RAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK--QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGY--------------NSSSCMSLAVTGSGGVGATGETR---------------PGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEV-VRCINQDEFAGFSFVNPKF 732          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENL-DPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI----ESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAG------ALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL---NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS-------------TQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+G + +K+ EA  L+ T    RH +       E L DPYV ++VDE    +++T+ K  +P W+++   DVT+   I  TV+HDAA+PPDDF+A    SFE +     +  D W++LEP+GK+ +   L  ++ ++   E +   T ++     +  RAG      A+RRR+HQ+ GHKF  T  +Q TFCS C  FIWG+  QGYQCQVCT VVHK+C+ +V+ +CPG++D   +    +    RFN+N+PH+F VH++ R  FCDHCGSLL+GL++QGLQCE C +N+HKRC+KNVA  CG+NTK + E +   G++P      PR  +        D+              Q      +   SL++   T    Y              + S+C    V  S  +G     R               P    L DFNF+KVLGKGSFGKV+LAE K T ++YAIK+LKK+ I+QD+DV+CTMTE+RILALAA HPFLTALHS FQT DRLFFVMEYVNGGDLMFQIQ+ RRF+  RA FY++EVTLAL FLH HG+IYRDLKLDNILLD EGHCKLADFGMCKEG+    LT+TFCGTPDYIAPEIL EQ+YG SVDWWALGVLMYEMMAG PPFE D E +LF++I +D V +P  L   +V I+  FL KNP +RLGC    G +  I +HPFF ++DW  LE+R I+PPFRPK+++  D +NFD +FT EDPVLTPI N   +  + +D FAGF F N  +
Sbjct:    2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIELK-NRTDKAKAEAVVEHTVAVNKEFKE--RAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK--QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGY--------------NSSSCMSLAVTGSGGVGATGETR---------------PGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEV-VRCINQDEFAGFSFVNPKF 732          

Query: 2424 VCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL---NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS-------------TQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4052
            VCT VVHK+C+ +V+ +CPG++D   +    +    RFN+N+PH+F VH++ R  FCDHCGSLL+GL++QGLQCE C +N+HKRC+KNVA  CG+NTK + E +   G++P      PR  +        D+              Q      +   SL++   T    Y              + S+C    V  S  +G     R               P    L DFNF+KVLGKGSFGKV+LAE K T ++YAIK+LKK+ I+QD+DV+CTMTE+RILALAA HPFLTALHS FQT DRLFFVMEYVNGGDLMFQIQ+ RRF+  RA FY++EVTLAL FLH HG+IYRDLKLDNILLD EGHCKLADFGMCKEG+    LT+TFCGTPDYIAPEIL EQ+YG SVDWWALGVLMYEMMAG PPFE D E +LF++I +D V +P  L   +V I+  FL KNP +RLGC    G +  I +HPFF ++DW  LE+R I+PPFRPK+++  D +NFD +FT EDPVLTPI N   +  + +D FAGF F N  +
Sbjct:   24 VCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK--QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGY--------------NSSSCMSLAVTGSGGVGATGETR---------------PGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEV-VRCINQDEFAGFSFVNPKF 547          

Query: 3999 HKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRC 4148
            H+F V  +K+FTFC  C S ++GL  QG QC+ C   VHKRC +NV   C
Sbjct:   67 HRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTC 116          

Query: 2424 RAGALRRR-IHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCG-------------VNTKDLVEAIK-KCGLN--PLDL-GYNPRYERTSTSANITDSTQKSSDL------PMHERSLSSPIPTHPDNYPITIE--------------------------PVN---KCLVLNSGSNCNKTGVDDSVIL----GDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4190
            R GAL+++ +  +K H F    FKQ TFCS C  FIWG   QG+QCQVC+ VVHKRC++ V   CPG KD    S++   +      H F   T+  P FCDHCGSLL+G+  QGL+C AC +N+H RC++NV   CG             +N K+ +  ++ K G N  P+D  G +  Y +     +  D ++K +        P+   +L+  +     +  I IE                          P N   K L  + G   N    DD   L       S K+ +  R  +         +   +DFNF+KVLGKGSFGKV+LAE K + ++YAIKILKK+VI+QD+DVECTM E+R+LAL  K PFL  LHS FQT DRLFFVMEYVNGGDLMFQIQ+  +F EP A FY++E+   L FLH  GI+YRDLKLDN+LLDA+GH K+ADFGMCKE + G K T TFCGTPDYIAPEI+  Q YG SVDWWA GVL+YEM+ G PPF+G+ E++LF AI+  +VS+P SL   + +    FL K P KRLGC +   G++ +  HPFFR IDW  +E R ++PPF+PK++ R D SNFDK FTSE   LTP +    +  L +  F GF + N +Y
Sbjct:   31 RKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFIWGFGKQGFQCQVCSYVVHKRCHEYVTFICPG-KDKGIDSDSPKTQ------HNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGS--SGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVF-MMNLDQSEFVGFSYMNPEY 666          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKIE----------EISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSS-SEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERS-LSSPIPTHP-DNYPIT-IEPVNKCLVLNS----GSNCNKTGVDDSVILGDRSS--KRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +K+ EA +LK TA + RHAVGP  + F  LD Y+ + VD+  VG++STK K N+P W+DE   +V  G  I  +V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS  E           + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG L  QGYQCQVCTCVVHKRC++ +I +C G+K    +  E    RF++N+PH F +H +  P FCDHCGSLL+GLMRQGLQC+ACK+N+H+RCE NVAP CGV+ + + + +   G+ P  +  + +  +  T     D  Q +++ P  E S      PT P D   +  +E + K L         S+ + +GV  + I G  +   K V + R S             L+DF+F+KVLGKGSFGKV+LAE K T +VYA+K+LKK+VILQD+DV+CT+TE+RILALA KHP+LT L   FQT DRLFFVMEYVNGGDLMFQIQR R+FDE R+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCV  +G ++AI  HPFFREIDWV LE+RRI+PPF+P+++++ D +NFD+DFT EDPVLTP++++  I  + ++ F GF +F  +
Sbjct:    1 MVVFNGVLKIKVCEALDLKPTAWSLRHAVGPKTQTFL-LDTYIALNVDDSRVGQTSTKQKTNSPAWNDEFVTEVYDGKKIELSVFHDAPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSCEAAASSNENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGMKKQEDTPEEVGSQRFSVNIPHMFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKACKMNVHRRCESNVAPSCGVDARKIAKVLSDLGVTPDKISNSTQRRKKLTPGQ--DPQQSTTEAPSSEESDRCKSAPTSPCDQAELAELESIRKALSFGQEHKSSSSSSCSGVQSTEIEGRENGDLKTVQTKRMS-------------LTDFSFIKVLGKGSFGKVMLAELKGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPSKRLGCVVTQGLEEAIKVHPFFREIDWVQLEQRRIKPPFKPRIKTKRDVNNFDQDFTREDPVLTPVDDAI-IKQINQEEFKGFSYFGEE 741          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKIE--------EISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTY-SSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDL-GYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPIT-IEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC----LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA +LK TA + RHAVGP  + F  LD Y+ + VD+  VG++STK K N+P W DE+  +V  G  I  +V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS  E         + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG L  QGYQCQVCTCVVHKRC++ +I +C G+K    ++ E    RF++N+PHKFR+H +    FCDHCGSLL+GL+RQGLQC+ CK+N+HKRCE NVAP+CGV+ + + + +   G+ P  L G   R ++ S   +           P+ E       PT P +  I  +E + K L  +  S   K   +             +S      +E G+   V      L DF+F+KVLGKGSFGKV+LAE + T +V+A+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDE R+ FY++EVT ALMFLH +G+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ K+P KRLGCV  +G + AI  HPFF++IDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLTP+E++  I  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIKICEALDLKPTAWSLRHAVGPKTQTF-LLDTYIALNVDDFRVGQTSTKQKTNSPAWHDELVTEVHDGRKIELSVFHDAPIGYDDFVANCTIQFEELLHNGSKHFEDWIDLEPEGKVFVIIDLSGSSSEAGGCENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQEDTAEEVGSQRFSVNMPHKFRIHNYKVLTFCDHCGSLLWGLLRQGLQCKVCKMNVHKRCEINVAPNCGVDARGIAKVLSDLGVTPDKLSGSVQRRKKISQGPD----PHPLPISPLLEEDRCKSAPTSPCDQDIKDLENIRKALSFDHRSEEMKQASEG------------VSEETGEARENGEVKTVQAKRMMLEDFSFIKVLGKGSFGKVMLAELRGTDEVFAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHHNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILDGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPSKRLGCVVSQGLEDAIKVHPFFKDIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVEDAI-IKQINQEEFKGFSYFGEE 735          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKIE--------EISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTY-SSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDL-GYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPIT-IEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC----LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA +LK TA + RHAVGP  + F  LD Y+ + VD+  VG++STK K N+P W DE+  +V  G  I  +V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS  E         + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG L  QGYQCQVCTCVVHKRC++ +I +C G+K    ++ E    RF++N+PHKFR+H +    FCDHCGSLL+GL+RQGLQC+ CK+N+HKRCE NVAP+CGV+ + + + +   G+ P  L G   R ++ S   +           P+ E       PT P +  I  +E + K L  +  S   K   +             +S      +E G+   V      L DF+F+KVLGKGSFGKV+LAE + T +V+A+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDE R+ FY++EVT ALMFLH +G+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ K+P KRLGCV  +G + AI  HPFF++IDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLTP+E++  I  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIKICEALDLKPTAWSLRHAVGPKTQTF-LLDTYIALNVDDFRVGQTSTKQKTNSPAWHDELVTEVHDGRKIELSVFHDAPIGYDDFVANCTIQFEELLHNGSKHFEDWIDLEPEGKVFVIIDLSGSSSEAGGCENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQEDTAEEVGSQRFSVNMPHKFRIHNYKVLTFCDHCGSLLWGLLRQGLQCKVCKMNVHKRCEINVAPNCGVDARGIAKVLSDLGVTPDKLSGSVQRRKKISQGPD----PHPLPISPLLEEDRCKSAPTSPCDQDIKDLENIRKALSFDHRSEEMKQASEG------------VSEETGEARENGEVKTVQAKRMMLEDFSFIKVLGKGSFGKVMLAELRGTDEVFAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHHNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILDGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPSKRLGCVVSQGLEDAIKVHPFFKDIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVEDAI-IKQINQEEFKGFSYFGEE 735          

Query: 2427 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI------ESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWN-QGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCL----SDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4649
            F+G + ++I EA +LK T  + RHAV    K  + LDPY++V+VDE  +G++ TK K N P +++E S +V +G  +   V+HDA I  DDF+A     F+ +      E + + W+DLEPEGK+ I   L GS I+E +     P  +    F+ K  R  A+RR+IHQ+ GHKF  T  KQ TFC  C  FIWG++  QGYQCQVCTCVVHKRC+Q V+  CP +K   +  ++    F+INVPHKF +H +  P FCDHCGSLL+G++RQGL C+ CK+N+H RC+ NVAP+              CG+N ++L                    K +++ +    L+                             N  G     + G  +  R +S R     E G + K  CL    S+F  ++VLGKGSFGKV+L     +  V+A+KILKK++ILQD+DVECTMTE+R+L+LA+ HP+LT L+  FQT +RLFFVME+VNGGDLMF IQ+ R+F+E RA FY++E+T AL+FLH  GI+YRDLKLDN+LLD +GHCKLADFGMCKEGM    +T TFCGTPDYIAPEIL E  YG SVDWWALGVL+YEM++G  PFE + E DLF +I  + + + S L   +VDI+  FL KNP +RLGCVA EGG+ A+  HPFF +IDW  L++R + PPF+P++++  D +NFD DFT EDP LTPI+ S  + ++ +D F GF F +++
Sbjct:    3 FNGYLKLRIGEAVDLKPTTTSMRHAV-MFNKATQTLDPYIVVKVDEYKIGQTHTKLKTNMPTYNEEFSVNVNNGKQVELAVFHDAPIGYDDFVANCTIQFDDLMKTNSREESFEGWVDLEPEGKVYILVTLTGSFIDEDAGGNARPYKE----FNRK--RQQAVRRKIHQVNGHKFMSTFLKQPTFCFHCKEFIWGVFGKQGYQCQVCTCVVHKRCHQLVVTVCPRMKKP-AKEQSTTQGFSINVPHKFSIHNYKVPTFCDHCGSLLWGIVRQGLHCKICKMNVHIRCKGNVAPN--------------CGINNVELA------------------NKLAEMGLQPGGLTKR---------------------------NSVG-----LAGLDAQSRTLSVR----GERGQSKKEQCLKLGISNFTLLQVLGKGSFGKVMLVRLNGSDQVFAVKILKKDIILQDDDVECTMTEKRVLSLASTHPYLTQLYCCFQTPERLFFVMEFVNGGDLMFHIQKSRKFEENRARFYTAEITSALIFLHSKGIVYRDLKLDNVLLDKDGHCKLADFGMCKEGMFDGIVTGTFCGTPDYIAPEILQELLYGPSVDWWALGVLLYEMLSGHAPFEAENEDDLFESILTEEIIYASWLSTNAVDILKGFLTKNPSRRLGCVATEGGETAVTGHPFFTDIDWDKLDQRALEPPFKPRIKTAEDVNNFDPDFTQEDPTLTPIDESI-LPSISQDDFRGFSFTSSE 677          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            +++W+DL+P GK+ +S        +  S+  ++   +   G    + R GA+++ ++H IK H+F  T FKQ TFCS+C  F+WGL  QGY+C+ C   +HK+C   +I RC G       +  Q  RF I++PH+F+ + +M P FCDHCGSLL+G+++QGL+CE C +N+H +C+  VA  CG+N K L EA+ +  L                      S+ K  D  + E  +   I                                D  +  D S +  + H P  +           L+DF F KVLGKGSFGKV+LAE K     +AIK LKK+V+L D+DVECTM E+R+LALA ++PFLT L+ +FQ+ + LFFVMEY+NGGDLMF IQ   RFD  RA FY++E+   L +LH  GI+YRDLKLDN++LD +GH K+ADFGMCKE M G    +TFCGTPDYIAPEIL  Q Y FSVDWW+ GVL+YEM+ G  PF+GD E +LF++I  D   +P  +   + D++ K   ++P +RLG V +      I  H FF+ I+W  LE+R + PPF+PKV+S +D SNFD++F SE P L+  + +  I ++ +  FAGF F N
Sbjct:  100 AEFWVDLQPSGKVMMSVQFFVEDTDLDSKASMT--AKDDDGILTINRRRGAIKQAKVHFIKNHEFTATFFKQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTMFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGMVKQGLKCEDCGMNVHHKCQTKVANLCGINQKLLAEALNQVSLK---------------------SSTKRPDPTLSEIGIYQAI--------------------------------DKNVPADPSGELALLHFPFRVS----------LNDFVFQKVLGKGSFGKVMLAELKGKGQYFAIKALKKDVVLMDDDVECTMVEKRVLALAWENPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAAEIICGLQYLHSKGIVYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLIGQSPFQGDDEDELFDSIRMDVPHYPRWITKEAKDLLEKLFERDPTRRLGVVGN------IRGHAFFKTINWPALEKREVSPPFKPKVKSSSDCSNFDREFLSEKPRLSQSDKNL-IDSMDQTAFAGFSFIN 661          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANI---------TDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC-------LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + ++I EA  LK TA + RHAVGP  + F  LDPY+ V VD+  +G++STK K+NNP W D+ S DV++G  I   V+HD+ I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+++ + + +   G+ P  +    +  +   +A I          ++ Q     P  E   S   PT P +  I      + K L  ++    +K+           ++     ++ S   E G+  +V         L DFNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA +G ++AI +HPFF+EIDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFL-LDPYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDKITAAGQRRKKKRNALIFSPMKLIAGAETQQPVPGGPAVEDDRSKSAPTSPCDQEIKDLENNIRKALSFDNRGEEHKS-----------TATAATENQLSGTGENGENGEVKLHEHKRTGLEDFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPFFKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGEE 750          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI-ESTSDYWLDLEPEGKLRISCILNGS---KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC-------LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + ++I EA  LK TA + RHAVGP  + F  LDPY+ V VD+  +G++STK K+NNP W D+ S DV++G  I   V+HD+ I  DDF+A     FE + ++ S ++ D   +G +  SC    S     E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+++ + + +   G+ P  +    +  +   +    ++ Q     P  E   S   PT P +  I      + K L  ++    +K+           ++     ++ S   E G+  +V         L DFNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA +G ++AI +HPFF+EIDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFL-LDPYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWVSDG-IGSSCKARESPKENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDKITAAGQRRKKLIAG--AETQQPVPGGPAVEDDRSKSAPTSPCDQEIKDLENNIRKALSFDNRGEEHKS-----------TATAATENQLSGTGENGENGEVKLHEHKRTGLEDFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPFFKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGEE 731          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI--------------------------------ESTSDY--------W-LDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC-------LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + ++I EA  LK TA + RHAVGP  + F  LDPY+ V VD+  +G++STK K+NNP W D+ S DV++G  I   V+HD+ I  DDF+A     FE +                                +  SDY        W +DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+++ + + +   G+ P  +    +  +   +    ++ Q     P  E   S   PT P +  I      + K L  ++    +K+           ++     ++ S   E G+  +V         L DFNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA +G ++AI +HPFF+EIDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFL-LDPYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWVLCICVQSLPVFGKVPRNHKKQILSDYGAGQRPGRWPIDLEPEGKVYVIIDLSGSSGEAPKENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDKITAAGQRRKKLIAG--AETQQPVPGGPAVEDDRSKSAPTSPCDQEIKDLENNIRKALSFDNRGEEHKS-----------TATAATENQLSGTGENGENGEVKLHEHKRTGLEDFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPFFKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGEE 776          

Query: 2538 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC-------LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNF 4658
            M  F+G + ++I EA  LK TA + RHAVGP  + F  LDPY+ V VD+  +G++STK K+NNP W D+ S DV++G  I   V+HD+ I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+++ + + +   G+ P  +    +  +   +    ++ Q     P  E   S   PT P +  I      + K L  ++    +K+           ++     ++ S   E G+  +V         L DFNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA +G ++AI +HPFF+EIDWVLLE+R+++PPF+P++ +R  +  +
Sbjct:    1 MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFL-LDPYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDKITAAGQRRKKLIAG--AETQQPVPGGPAVEDDRSKSAPTSPCDQEIKDLENNIRKALSFDNRGEEHKS-----------TATAATENQLSGTGENGENGEVKLHEHKRTGLEDFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPFFKEIDWVLLEQRKVKPPFKPRIVNRESSHAY 703          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQC-------QVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + ++I EA  LK TA + RHAVGP  + F  LDPY+ V VD+  +G++STK K+NNP W D+ S DV++G  I   V+HD+ I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS  E                  GK  R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FI  +    ++         VCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+++ + + +    +  L+        R + S +      KS+     E  LS                        +G N            G+    ++  H+ + L+            DFNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA +G ++AI +HPFF+EIDWVLLE+R+++PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  +
Sbjct:    1 MVVFNGLLKIRICEATNLKPTAWSLRHAVGPRPQTFL-LDPYIAVNVDDSRIGQTSTKQKSNNPTWHDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGE------------------GKK-RQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFICDVNGCFFEIIPLVFLFPVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLEIKDLENNI-----RKALSFDNRGEEHKSTATAATENQLSG-----------------------TGEN------------GENGEVKLHEHKRTGLE------------DFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPFFKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGEE 682          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEP-VNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R   +A   +S Q +S     E   S   PT P D     +E  + K L   N G     +   D  +     +  V   RP   +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+P+LT ++ +  I  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLAAG-AESPQPASGNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEV---RPGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAI-IKQINQEEFKGFSYFGED 734          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEP-VNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R   +A   +S Q +S     E   S   PT P D     +E  + K L   N G     +   D  +     +  V   RP   +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+P+LT ++ +  I  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLAAG-AESPQPASGNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEV---RPGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAI-IKQINQEEFKGFSYFGED 734          

Query: 2418 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS------DYWLDLEPEGKLRISCILNGSKIEE-ISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWN-QGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL--NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNI 4649
            F+G + V+I EA  L+ T  + RH++    K  + LDPY+ V VD+  VG++STK K N P +++E   +VT G  +   V+H+  +  D F+A     F+ +  T+      + W+DLEPEGK+ +   L GS  E  + R+++          H    R  A+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG++  QGYQCQVCTCVVHKRC+  ++  C   ++  +  +A++   RF IN+PHKF VH +  P FCDHCGSLL+G+MRQGLQC+ CK+N+H RC+ NVAP+CGVN  +L + +   GL P ++        + TS  I+ ST +                                          K G  +   +G  SS R           +G       + +F F++VLGKGSFGKV+LA  K T ++YA+K+LKK+VILQD+DVECTMTE+RIL+LA  HPFLT L   FQT DRLFFVME+VNGGDLMF IQ+ RRFDE RA FY++E+  ALMFLH+ GIIYRDLKLDN+LLD EGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E  YG +VDWWA+GVL+YEM+ G  PFE + E DLF AI  D V +P+ L   +  I+  F+ KNP  RLG +  +GG+  I+RHPFF+EIDW  L  R++ PPFRP+++SR D SNFD DF  E+PVLTPI+    +  + +D F  F + + +  +
Sbjct:    8 FNGYLRVRIGEAVGLQPTRWSLRHSL--FKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAGTSDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDRIFK--------HFTRKRQRAMRRRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACT-CQNNINKVDAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNI--------SPTSKLISRSTLRRQ---------------------------------------GKEGSKEGNGIGVNSSSR-----------FG-------IDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHEILRHPFFKEIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEG-HLPMINQDEFRNFSYVSPELQL 683          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVD-DSVILGDRSS----KRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            ++ WL+L+P+G++    ++N     E+S  K     ++  GF   H R GA+++ ++H +K H+F  T F Q TFCS+C+ F+WGL  QGYQC+ C   +HK+C   VI +C G       +     RF I++PH+F+V+ +  P FC+HCG+LL+GL RQGL+C+AC +N+H RC+  VA  CG+N K + EA+                E T  + ++ DS     + P+    +  P  T  +  P  +    K             G+  DS + G   S    +  +S R +SLQ          + DF   K+LGKGSFGKV LAE K T   +AIK LKK+V+L D+DVECTM E+R+L+LA +HPFLT +  +FQT + LFFVMEY+NGGDLM+ IQ   +FD  RA FY++EV L L FLH  GI+YRDLKLDNILLD +GH K+ADFGMCKE M G   T+TFCGTPDYIAPEIL  Q Y  SVDWW+ GVL+YEM+ G  PF G  E++LF++I  D+  +P  L+  + D++ K  ++ P KRLG       +  I +HP FREI+W  LE + I PPFRPKV+S  D SNFDK+F SE P L+   +   I ++ +++F+ F F N
Sbjct:  103 TEIWLELKPQGRM----LMNARYFLEMSDTKDMSEFEN-EGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALA-------------MIESTQQARSLRDSEHIFREGPV---EIGLPCSTKNETRPPCVPTPGKR---------EPQGISWDSPLDGSNKSAGPPEPEVSMRRTSLQLKLK------IDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV------RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLS-FADRALINSMDQNMFSNFSFIN 698          

Query: 2415 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDST---QKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIF 4331
            +++WLDL+P+ K+ + C+       E    K S  ++    F   + R    + +IH IK H+F  T F Q TFCS+C  F+WGL  QGY+C+ C   +HK+C   +I RC G       +  Q  RFNI++PH+F+V+ +M P FCDHCGSLL+GL++QGL+CE C +N+H +C + VA  CG+N K L EA+            N   +R+S   + T+S    Q     P  E S S  +     +  + +   ++    +S   C+  G    +  G   S R                    L +F F KVLGKGSFGKV+LAE K     +AIK LKK+V+L D+DVECTM E+R+LALA + PFLT L  +FQT D LFFVME++NGGDLMF IQ   RF+  RA FY++E+   L FLH  GIIYRDLKLDN++LD +GH K+ADFGMCKE + G    STFCGTPDYIAPEIL    Y FSVDWW+ GVL+YEM+ G  PF GD E +LF +I  D+  +P  +   S DI+ K   ++P KRLG   +      I  HPFF+ I+W LLE+R++ PPF+PKV+S +D SNFD +F +E P L+   +   I ++ ++ F GF F N  +  F
Sbjct:  102 AEFWLDLQPQAKV-LMCV---QYFLEDGDCKQSMRSEEEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEAL------------NQVTQRSSRKLDTTESVGIYQGFEKKP--EVSGSDILGEAGSHISLKLSFPSRAKEKDSSETCDNNGTYGKIWEG---STRCT------------------LENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGN------IRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLS-FSDKNLIDSMDQEAFHGFSFVNPKFEQF 697          

Query: 2424 FSGSVTVKIIEAKELKATACATRHAVGPTA-KLFENLDPYVIVEVDERIVGXXXXXXXXXXXXX--SDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGK-HYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDN---YPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFRE-IDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4649
            F+GSV +K+ EA +LK T  + R   G T  K  + ++PYV ++VDE  + K++TK K+  P+W  +++ + +V +G  +  TV+HDAAIPPD+F+A     F+ ++  SD+W+DLEP GKL +   L GS  E       +P  +      G  + R GA+RRR+HQ+ GHKF    F+Q TFCSLC  FIWGL  QGYQCQVCTCVVHKRC+Q+++ +CPG +D  ++ E    RFNINVPH+F VH + RP FCDHCGSLL+GL+RQGLQC+ CK+NIHKRC+KNVA +CG NT+D+ + +++ G++   L   P+ ++ S S +  +S  KSS  PMHERSLSSPIP   D+    P  +   +  L +N+ +    +          RS    IS                 L DFNF+KVLGKGSFGKV+LAE K T +VYAIK+LKK+VI+QD+DVECTMTE+RILAL+AKHPFLTALHSSFQT +RLFFVMEYVNGGDLMFQIQR R+FDEPRA FY++EVTLALMFLH+HGIIYRDLKLDNILLDAEGHCK+ADFGMCKEGM+ +KLT TFCGTPDYIAPEIL E  Y  SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCV  +G ++AI+ HPFF E IDW  LE+R+++PPF+PK++++TD +NFD+DFTSEDPVLTP++ +  I  + ++ F GF F N DY
Sbjct:    9 FNGSVKIKVCEAVDLKPTDFSLRLQKGSTKEKASQMIEPYVNIDVDEVYIAKTTTKPKSVKPQWVWNEDFTSEVHNGQNVNLTVFHDAAIPPDEFVANCTIPFDDVKGKSDFWIDLEPNGKLHVVIELCGSATEAAES---TPKEKVFKEKEGMLNRRRGAMRRRVHQVNGHKFMAMFFRQPTFCSLCRDFIWGLGKQGYQCQVCTCVVHKRCHQHIVTKCPGSRDV-ANDEVTGKRFNINVPHRFNVHNYRRPTFCDHCGSLLYGLVRQGLQCDVCKMNIHKRCQKNVANNCGTNTRDMAQILQEMGISGDKL--RPKTKKLSISES-HESPNKSS--PMHERSLSSPIPVIQDSDEAQPGEMGLPSDSLPVNASNEHQGSRTRSPSSDRSRSHHSRIS-----------------LHDFNFIKVLGKGSFGKVMLAEKKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILALSAKHPFLTALHSSFQTKERLFFVMEYVNGGDLMFQIQRARKFDEPRARFYAAEVTLALMFLHRHGIIYRDLKLDNILLDAEGHCKIADFGMCKEGMTENKLTQTFCGTPDYIAPEILQELKYDASVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKGFMTKNPAKRLGCVTTQGCEKAILVHPFFHEKIDWEALEQRKVKPPFKPKIKNKTDANNFDRDFTSEDPVLTPVDPAV-IKTINQEEFRGFSFANPDY 731          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEP-VNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R   +A   +S Q +S     E   S   PT P D     +E  + K L   N G     +   D  +     +  V   RP   +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+P+LT ++ +  I  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLAAG-AESPQPASGNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSATDGQLASPGENGEV---RPGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAI-IKQINQEEFKGFSYFGED 734          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI--EPVNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEG++ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  +    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R    A   +S Q +S     E   S   PT P +  I      + K L   N G         D  ++    +  V   R    +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLIAG-AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEV---RQGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGED 734          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEP-VNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +  G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P  +  +   +R        +S Q +S     E   S   PT P D     +E  + K L  ++    ++        LG   +  V   R    +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++I+PPF+P+++++ D +NFD+DFT E+PVLT ++ +  +  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKVAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSG--QRRKKLIGGAESPQPTSGSSPSEEDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRAASSTDGQLGSPENGEV---RQGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI-VKQINQEEFKGFSYFGED 733          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGS-------KIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEP-VNKCLVL-NSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  F+G + +KI EA  LK TA + RHAVGP  + F  LDPY+ + VD+  +G+++TK K N+P W DE   DV +G  I   V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG +  QGYQCQVCTCVVHKRC++ +I +C G+K   +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P D   N    R   +A   +S Q +S     E   S   PT P D     +E  + K L   N G     +   D  +     +  V   R    +  G       L +FNF+KVLGKGSFGKV+LAE K   +VYA+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGH KLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCVA + G+ AI +HPFF+EIDWVLLE+++++PPF+P+++++ D +NFD+DFT E+P+LT ++ +  +  + ++ F GF +F  D
Sbjct:    1 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL-LDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP-DKITNSGQRRKKLAAG-AESPQPASGNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSSTDGQLASPGENGEV---RQGQAKRLG-------LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSGFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHSKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKMKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAI-VKQINQEEFKGFSYFGED 734          

Query: 2373 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLS-PGTQS-IGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL-NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTST-------SANITDSTQKSSDLPM---------------------------------------------HERSLSSPI--PTHPDNYPITI---EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVIS-------HRPSSLQ------EYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMN 4658
            M+YFSG++ ++I EA ELK TACATRHAVGP AKL+E LDPYV ++VD+  +GKSSTK++ N P+W+++I  +V++   +TFTVYHDAAIPPDDF+AI + +  ++ S  D WL+LEP+GKL I   L G++ +E  R++   PG  S IGG HGKHYR GALRRRIHQ KGHKFQVT  +QFTFCSLCN FIWGLWNQGYQCQVCTCVVHKRCY NVI +CPGVK   S   A L +RFNINVPHKFR+HTFM PAFCDHCGSLLFGLMRQGLQCE C+LNIHKRCEKNVA HCGVNT++LV AI+ CGLNP DLG +P    T T        +  T ST  SS  P+                                             HERS SSPI  PT  D   + I      N    ++   +   T   D +  G  S+   ++        RPSSLQ      EY    ++PCL+DF F+KVLGKGSFGKV+LAE+KST +V+A+K+LKKEVILQDEDV+CT+TE+RIL LAA HPFLTAL+ +FQT+DRLFFVMEYVNGGDLM+QIQR RRFDE RA FY++EV LALMFLH H I+YRDLKLDNILLDAEGHCKLADFGMCKEGM   + TSTFCGTPDYIAPEILAE DYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISY+ V++P +L P +VDI+SKFL+K+P +RLGC+  +GG+ AI RHPFF+EIDW +LEERR+RPPFRPKVRSR DTSNFDKDFT+E+P+LTP +NS E+AA+ +DVFA FD FN DY++ R+H  RPSQQQP+ 
Sbjct:    1 MEYFSGTLNIRIFEAAELKPTACATRHAVGPAAKLYEFLDPYVTIDVDDIAIGKSSTKSRTNVPQWNEDICAEVSYAQQLTFTVYHDAAIPPDDFVAIVELAIRNVRSGEDMWLELEPQGKLHIRIDLAGTRTDEPPRDRPGFPGRDSAIGGVHGKHYRCGALRRRIHQAKGHKFQVTSLRQFTFCSLCNGFIWGLWNQGYQCQVCTCVVHKRCYLNVITQCPGVKSPPSCPTAALQSRFNINVPHKFRIHTFMLPAFCDHCGSLLFGLMRQGLQCEVCRLNIHKRCEKNVASHCGVNTRNLVAAIRLCGLNPSDLGVSPSGTTTMTLTGPGVTGSTRTASTTVSSVRPISAGPRGGGCHYGVYGDIVFPTSPGPLKPSKGDTGFSSSSLIGIAPHERSFSSPISLPTT-DLSGVGIGRDNGANAVGNMDVDESIRYTATLDPISGGSLSTAGPVAGRHGMPAQRPSSLQDPPDVYEYTTGSQIPCLNDFTFLKVLGKGSFGKVMLAEYKSTGEVFAVKVLKKEVILQDEDVDCTLTERRILVLAAHHPFLTALYCAFQTEDRLFFVMEYVNGGDLMYQIQRARRFDEARARFYAAEVILALMFLHNHHIVYRDLKLDNILLDAEGHCKLADFGMCKEGMKPGRTTSTFCGTPDYIAPEILAELDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYEEVTYPPNLNPDAVDILSKFLVKSPARRLGCIPTDGGELAIQRHPFFKEIDWQILEERRVRPPFRPKVRSRIDTSNFDKDFTTEEPILTPSDNSSELAAIAQDVFADFDCFNVDYSVMRYHTTRPSQQQPLQ 834          

Query: 2376 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLS--PGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL-NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYN---------PRYERTSTSANITDSTQKSSDLPM-----------HERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGD--------------------TPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPM 4658
            M+YFSG++ ++++EA ELKATACATRHAVGP AKL+E LDPYV +EVD+  + K+STK+K N+P+W + +  +VT    +TFTVYHDAAIPPDDF+AIA+    ++ +  ++WL+LEP+G+L++   L G++ +E  +        T S G  H KHYRAGALRRRIHQ KGHKFQVT+ KQFTFCSLCN FIWGLWNQ YQCQVCTCVVHKRCYQNVI +CPGVK   +   A L NRFNINVPHKFRVHT+M P FC+HCGS+LFGLMRQGLQCE CK N+H+RCEKNVA HCGV T++L+ AI++CGLNP DLG                 S   +     +++   P            HERS SSPIP  P                 + S+   + +D   +  D +S  +I+HRPSS+ E  +                     P++P L+DF+ +KVLGKGSFGKV+LAEH++T +V+A+KILKKEVI+Q+EDVECTM E+RIL LAA+HPFLTAL+ SFQT+DRLFFVMEYVNGGDLMFQIQR RRFDE RA FY++EV LALMFLH+H I+YRDLKLDNILLDAEGHCKLADFGMCKEGM   + TSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEM+AGAPPFEGDTEQDLFN+ISY  V +PSSLQP +VDI+S+FL+K+P++RLGCV  EGG+ AI RHPFFREIDW LLEER+IRPPFRPKVRSR DT+NFDKDFT+EDPVLTP ++S E+AA+ +DVFA FD  N+DY++ RHH  RPSQQQP+
Sbjct:    1 MEYFSGTIHIQVLEATELKATACATRHAVGPAAKLYELLDPYVTIEVDDLAIAKTSTKSKTNSPRWKENVKAEVTSAQRLTFTVYHDAAIPPDDFVAIAELLMRNVRAGKEFWLELEPQGRLKLQIDLIGTRTDEPPKLAFDKDSSTSSSGVLHAKHYRAGALRRRIHQAKGHKFQVTVLKQFTFCSLCNDFIWGLWNQAYQCQVCTCVVHKRCYQNVITQCPGVKALPTGPNAVLQNRFNINVPHKFRVHTYMLPTFCEHCGSILFGLMRQGLQCEVCKANVHRRCEKNVASHCGVKTRNLITAIRQCGLNPSDLGLTGEAVAAASAVEVSVRSAPTDHVHHLKRAELYPCGSGGGSGSGAPHERSFSSPIPMPPTT--------------PNDSDKAASDLDAMNLSEDSASHGLIAHRPSSMMEGEEGEVATAAVGPASAVTSRRHFVPRIPRLADFSLLKVLGKGSFGKVMLAEHRATGEVFAVKILKKEVIIQEEDVECTMAERRILVLAAQHPFLTALYCSFQTEDRLFFVMEYVNGGDLMFQIQRARRFDEARARFYAAEVVLALMFLHRHFIVYRDLKLDNILLDAEGHCKLADFGMCKEGMFPGRTTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMLAGAPPFEGDTEQDLFNSISYGDVKYPSSLQPEAVDILSRFLLKSPVRRLGCVMSEGGELAIQRHPFFREIDWKLLEERKIRPPFRPKVRSRFDTTNFDKDFTNEDPVLTPPDHSNELAAIEQDVFAAFDCVNSDYSVLRHHATRPSQQQPL 790          

Query: 2376 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLS-PGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL-NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGY-------------------NPRYERTSTSANITDSTQKS---------------------SDLPMHERSLSSPIPTHPDNY---PITIEPV----NKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTP--------------KVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPM 4658
            M YFSG++ V+IIEA ELK TACATRH++ P AKL E LDPYV V+VD+  +GKSSTK++ N P W++++S +V +   +TFTVYHDAAIPPDDF+AI + +  ++ S  D W++LEP GKL I   L+G++ +E  R++L  P   S  G H KHYR GA+RRRIHQ KGHKFQVT  KQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCY NVI +CPGVK   +   A L NRFNINVPHKFR+HTFM PAFCDHCGSLLFGLMRQGLQCE C+L+IHKRCE+NVA HCGVNT+DL+ AI+ CGLNP DLG                    +P    +S+S  ++   + S                     S +  HERSLSSPIP  P+ +   PI  + +    +   VL SG    + GV  +              RPSSLQ   D P              ++P L DF F+KVLGKGSFGKV+LAE K T +V+A+K+LKKEVILQDED++CTMTE+RIL LAA+HPFLTAL+ +FQT+DRLFFVMEYVNGGDLMFQIQR RRFDE RA FY++EVTLALMFLH+H I+YRDLKLDNILLDAEGHCKLADFGMCKEGM+  K TSTFCGTPDYIAPEILAE DYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISY+ V++P +L P +VDI+SKFL+K+P +RLGCVA +GG+ AI  HPFFREIDW +LEERRIRPPFRPKVRSR DTSNFDKDFT+E+PVLTP +++ E+ A+ KDVFA FD  NTDY++ R+H  RPSQQQP+
Sbjct:    1 MDYFSGTLNVRIIEASELKPTACATRHSLRPVAKLCELLDPYVTVDVDDIAIGKSSTKSRTNTPLWNEDVSAEVNYAQQLTFTVYHDAAIPPDDFVAIVEVAIRNVRSGEDVWIELEPHGKLHIRIDLSGTRTDEPPRDRLGFPSRDSAIGVHAKHYRCGAMRRRIHQAKGHKFQVTSLKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYLNVITQCPGVKSPPTGPTALLQNRFNINVPHKFRIHTFMLPAFCDHCGSLLFGLMRQGLQCEVCRLSIHKRCERNVASHCGVNTRDLIAAIRLCGLNPSDLGVIPTTSSIGSIGSPPPTNAVSPGPHASSSSRPVSAGLRTSGIYGAYTDFGTGESRLTGITPSMINPHERSLSSPIPLPPNVFSENPIESDAMTLHSSGAAVLMSGPVYGRHGVPVA--------------RPSSLQ---DPPAIHHTTTSSDVASIRIPNLKDFIFLKVLGKGSFGKVMLAEQKGTGEVFAVKVLKKEVILQDEDIDCTMTERRILVLAARHPFLTALYCAFQTEDRLFFVMEYVNGGDLMFQIQRARRFDEARARFYAAEVTLALMFLHRHHIVYRDLKLDNILLDAEGHCKLADFGMCKEGMTPGKTTSTFCGTPDYIAPEILAESDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYEEVTYPPNLHPDAVDIMSKFLLKSPARRLGCVAVDGGELAIQCHPFFREIDWEILEERRIRPPFRPKVRSRIDTSNFDKDFTNEEPVLTPTDHTSELTAIAKDVFAEFDCINTDYSVMRYHTTRPSQQQPL 807          

Query: 2373 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQS----IGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL-NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSA-NITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMN 4658
            M+YFSG++ ++I EA ELK TACATRHAVGP AKL+E LDPYV ++VD+  VGKSSTK++ N P+W+++I   V +   +TFTVYHDAAIPPDDF+AI + +   +    D WL+LEP+GKL I   L G++ +E  R++  PG  S    IGG HGKHYR GALRRRIHQ KGHKFQVT  +QFTFCSLCN FIWGLWNQGYQCQVCTCVVHKRCY NVI +CPGVK   S   A L +RFNINVPHKFR+HTFMRPAFCDHCGSLLFGLMRQGLQCE C+LNIHKRCEKNVA HCGVNT++LV AI+ CGLNP DLG +P    T T    +T  ++ +S       ++SS  P                  +++GS     GV      GD     V S  P  L+      ++PCL DF+F+KVLGKGSFGKV+LAE+KST +V+A+K+LKKEVILQDEDV+CT+TE+RIL LAA HPFLTAL+ +FQT+DRLFFVMEYVNGGDLMFQIQR RRFDE RA FY++EV LALMFLH H I+YRDLKLDNILLDAEGHCKLADFGMCKEGM   + TSTFCGTPDYIAPEILAE DYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISY+ V++P +L   +VDI+SKFL+K+P +RLGCV  +GG+ AI RHPFF+EIDW +LEERR+RPPFRPKVRSR DTSNFDKDFT+E+PVLTP +NS E+AA+ +DVFA FD FN DY++ R+H  RPSQQQP+ 
Sbjct:    1 MEYFSGTLNIRIYEAAELKPTACATRHAVGPAAKLYELLDPYVTIDVDDNAVGKSSTKSRTNIPQWNEDICARVNYAQQLTFTVYHDAAIPPDDFVAIVELALRDVRFGEDMWLELEPQGKLLIRIDLAGTRTDEPPRDR--PGFPSRDSAIGGVHGKHYRCGALRRRIHQAKGHKFQVTSLRQFTFCSLCNGFIWGLWNQGYQCQVCTCVVHKRCYLNVITQCPGVKSPPSCPTAALQSRFNINVPHKFRIHTFMRPAFCDHCGSLLFGLMRQGLQCEVCRLNIHKRCEKNVASHCGVNTRNLVAAIRLCGLNPSDLGVSPSGTTTLTPGPGVTGPSRTAST------TISSVRP------------------ISAGSR----GVGPFGAYGDV----VFSTSPGPLKP-SKASQIPCLMDFSFLKVLGKGSFGKVMLAEYKSTGEVFAVKVLKKEVILQDEDVDCTLTERRILVLAAHHPFLTALYCAFQTEDRLFFVMEYVNGGDLMFQIQRARRFDEARARFYAAEVILALMFLHNHHIVYRDLKLDNILLDAEGHCKLADFGMCKEGMKPGRSTSTFCGTPDYIAPEILAELDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYEEVTYPPNLNSDAVDILSKFLVKSPSRRLGCVPADGGELAIQRHPFFKEIDWQILEERRVRPPFRPKVRSRIDTSNFDKDFTTEEPVLTPSDNSSELAAIAQDVFADFDCFNVDYSVMRYHTTRPSQQQPLQ 733          

Query: 2373 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQS----IGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQL-NRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERT------STSANITDSTQKSSDLPM--------------------------------------------HERSLSSPI--PTHPDNYPITIEPVNKCLVLN-SGSNCNKTGVDDSVILGDRSSKRVIS-------HRPSSLQEYGDT------PKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMN 4658
            M+YFSG++ ++I EA ELK TACATRHAVGP AKL+E LDPYV ++VD+  VGKSSTK++ N P+W+++I   + +   +TFTVYHDAAIPPDDF+AI + +   +    D WL+LEP+GKL I   L G++ +E  R++  PG  S    IGG HGKHYR GALRRRIHQ KGHKFQVT  +QFTFCSLCN FIWGLWNQGYQCQVCTCVVHKRCY NVI +CPGVK   S   A L +RFNINVPHKFR+HTFMRPAFCDHCGSLLFGLMRQGLQCE C+LNIHKRCEKNVA HCGVNT++LV AI+ CGLNP DLG +P    T       T  + T ST  SS  P+                                            HERSLSSPI  PT   +             ++   S+     +D +   G  S+   ++        RPSSLQ+  D        ++PCL DF F+KVLGKGSFGKV+LAE+KST +V+A+K+LKKEVILQDEDV+ T+TE+RIL LAA HPFLTAL+ +FQT+DRLFFVMEYVNGGDLMFQIQR RRFDE RA FY++EV LALMFLH H I+YRDLKLDNILLDAEGHCKLADFGMCKEGM   + TSTFCGTPDYIAPEILAE DYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISY+ V++P +L P +VDI+SKFL+K+P +RLGCV+ +GG+ AI RHPFF+EIDW +LEERR+RPPFRPKVRSR DTSNFDKDFT+E+PVLTP +NS E+AA+ +DVFA FD FN DY++ R+H  RPSQQQP+ 
Sbjct:    1 MEYFSGTLNIRIYEAAELKPTACATRHAVGPAAKLYELLDPYVTIDVDDNAVGKSSTKSRTNIPQWNEDICARINYAQQLTFTVYHDAAIPPDDFVAIVELALRDVRFGEDMWLELEPQGKLLIRIDLAGTRTDEPPRDR--PGFPSRDSAIGGVHGKHYRCGALRRRIHQAKGHKFQVTSLRQFTFCSLCNGFIWGLWNQGYQCQVCTCVVHKRCYLNVITQCPGVKSPPSCPTAALQSRFNINVPHKFRIHTFMRPAFCDHCGSLLFGLMRQGLQCEVCRLNIHKRCEKNVASHCGVNTRNLVAAIRLCGLNPSDLGVSPSGTTTLTPGPGVTGPSRTASTTISSVRPISAGSRGVGPFGAYGDVVFSTSPGPLKPSKGDAGFSSSSLIGVAPHERSLSSPISMPTTDLSSSGIGRGAPGGGSMDIDESSSRYAALDPTSGSGSLSTAGPVAGRHGMPAQRPSSLQDPPDAHGCTTASQIPCLMDFTFLKVLGKGSFGKVMLAEYKSTGEVFAVKVLKKEVILQDEDVDGTLTERRILVLAAHHPFLTALYCAFQTEDRLFFVMEYVNGGDLMFQIQRARRFDEARARFYAAEVILALMFLHNHHIVYRDLKLDNILLDAEGHCKLADFGMCKEGMKPGRSTSTFCGTPDYIAPEILAELDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYEEVTYPPNLNPDAVDILSKFLVKSPSRRLGCVSADGGELAIQRHPFFKEIDWQILEERRVRPPFRPKVRSRIDTSNFDKDFTTEEPVLTPSDNSSELAAIAQDVFADFDCFNVDYSVMRYHTTRPSQQQPLQ 831          

Query: 2427 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKI-------EEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSS-SEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4658
            M  ++G + +K+ EA +LK T  + RHAVG   + F  LD Y+ + VD+  VG++STK K N+P W+DE   +V  G  I  +V+HDA I  DDF+A     FE +        + W+DLEPEGK+ +   L+GS         E + RE++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS                 +CTCVVHKRC++ +I +CPG+K    +  E    RF++N+PHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +        DLG  P          I++STQ+                                    +GS   + G   S+      SKR+                   L+DF+F+KVLGKGSFGKV+LAE K + +VYA+K+LKK+VILQD+DV+CT+TE+RILALA KHP+LT L   FQT DRLFFVMEYVNGGDLMFQIQR R+FDE R+ FY++EVT ALMFLH+HG+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ K+P KRLGC+  +G ++AI  HPFFREIDWVLLE+R+I+PPF+P+++++ D +NFD+DFT EDPVLTP++++  I  + ++ F GF +F  +
Sbjct:    1 MVVYNGLLKIKVCEALDLKPTPWSLRHAVGTRTQGFL-LDTYIALNVDDSRVGQTSTKQKTNSPAWNDEFVTEVYDGKKIELSVFHDAPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSTAASSENEERVFRERMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCS----------------HLCTCVVHKRCHELIITKCPGLKKQDDTPEEVGSQRFSVNMPHKFSIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLS-------DLGVTP--------DKISNSTQRRKK--------------------------------GTGSEGRENGDLKSI-----QSKRM------------------NLTDFSFIKVLGKGSFGKVMLAELKGSDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPNKRLGCMVSQGLEEAIKVHPFFREIDWVLLEQRKIKPPFKPRIKTKRDVNNFDQDFTREDPVLTPVDDAI-IKQINQEEFKGFSYFGEE 657          

Query: 2427 LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSD------LPMHERSLSSPIPTHP-DNYPITIEPVNKCLVLN---------SGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTD 4079
            L  QGYQCQVCTCVVHKRC++ +I +C G+K    ++E    RF++N+PHKF +H +  P FCDHCGSLL+GLMRQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P         ++ S+S        +  D       P  E   S   PT P D      E + K L  +         + S+ N+ G ++S    + S  + +  +  SL+            DF+F+KVLGKGSFGKV+LAE + T +VYA+K+LKK+VILQD+DV+CT+TE+RILALA KHP+LT L   FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH++G+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ K+P KRLGCV  +G ++AI  HPFF+EIDWVLLE+R+I+PPF+P+++++ D +NFD+DFT E+PVLTP++++  I  + +D F GF +F  +
Sbjct:    5 LGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQEDTAEVGSQRFSVNMPHKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCESNVAPNCGVDARGIAKVLSDLGVTP---------DKISSSVQRRKKISQGPDPQPLPISPQTEEDRSKSAPTSPCDQDAKDSENIRKALSFDHRGEELKPEAPSSLNEAGAEESGEARENSEVKTLQTKRMSLE------------DFSFIKVLGKGSFGKVMLAELRGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHRNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILDGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPNKRLGCVVSQGMEEAIKVHPFFKEIDWVLLEQRKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVDDAI-IKQINQDEFKGFSYFGEE 549          

Query: 3999 HKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRC 4148
            HKF +  +K  TFC  C S +WGL  QG QC+VC   VH+RC  NV   C
Sbjct:   54 HKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCESNVAPNC 103          

Query: 2487 FSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS------DYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLW-NQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENS 4649
            F+G + +++ EA +LK T  +TRH +    K    LDPY++V+VD+  VG+++ K K + P +++E    V+ G  +   V+HD  I  DDF+A      E + ++S      + W++LEP G + I   L GS  ++ S      G ++      K  RA  LRR++HQ+ GHKF  T  KQ TFC  C +FIWG++  QGYQCQVCTCVVHKRC+  V+  CP +K       +Q   F+IN+PH+F+VH +  P +C+HCGSLL+GL++QGL C+ CK+N+H RCE+NVAP+CGVN+  L   + + GL P               + +T S  K        +S++              E + +         C K G+DD   L      RV                   L   +F KV+         LA   S+  V+A+KILKK++ILQD+DVE TM E+R+L+LA +HP+LT L+  FQT DRLFFVME+VNGGDLMF IQ+ RRF+E RA FY++E+T ALMFLH  GIIYRDLKLDN+LLD +GHCKLADFGMCKEG+     T+TFCGTPDYIAPEI+ E+ YG SVDWWALGVL+YEM++G  PFE +TE +LF +I  D V + S L   + DI+  FL K+P  RLGC   +GG++AI  H FF+++DW  L++R + PPF+P+++S  D +NFD DFT E+P LTPIE +
Sbjct:    3 FNGYMRLRVGEAVDLKPTTFSTRHTLN---KKTHQLDPYIVVKVDDFKVGQTAIKPKTSRPAFNEEFCPYVSEGKELEIAVFHDTPIGYDDFVANCRIQLEDLLTSSSSRQSFEGWVNLEPVGSIYIYVSLTGSFTDDDS---TCNGIKTHKELTRKRQRA--LRRKVHQVNGHKFMATFLKQPTFCCHCKNFIWGVFGKQGYQCQVCTCVVHKRCHHLVVSECPRMKKAACEEPSQ--GFSINLPHQFKVHNYKVPTYCNHCGSLLYGLVKQGLHCKGCKMNVHIRCEENVAPNCGVNSAQLASKLAEMGLQP---------------SKLTKSVSK--------KSITVKSSNSSVKSEGQSEGIEE--------ECVKVGLDDFTFL------RV-------------------LGKGSFGKVM---------LARMNSSDRVFAVKILKKDIILQDDDVESTMIEKRVLSLAQQHPYLTHLYYCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFEEVRAQFYAAEITSALMFLHSKGIIYRDLKLDNVLLDKDGHCKLADFGMCKEGICNGVRTNTFCGTPDYIAPEIIQEEQYGVSVDWWALGVLLYEMLSGHAPFEAETEDELFESILRDEVIYSSWLSNEAEDILKGFLTKDPSCRLGCTERDGGEKAIAAHMFFKDLDWEKLKKRELEPPFKPRIKSFEDVNNFDLDFTQEEPTLTPIEEA 655          

Query: 2487 VNMKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS------DYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENS 4664
            ++MK F+G + +++ EA +LK T  +TRH +    K    LDPY++V+VD+  VG+++ K K + P +++E    V+ G  +   V+HD  I  DDF+A      E + ++S      + W++LEP G + I   L GS          + G            R  ALRR++HQ+ GHKF  T  KQ TFC                C +CTCVVHKRC+  V+  CP +K    S       F+IN+PH+F+VH +  P +C+HCGSLL+GL++QGL C+ CK+N+H RCE+NVAP+CGVN+  L   + + GL P  L                             +S+S  +    +     IE             C K G+DD   L      RV                   L   +F KV+         LA   S+  V+A+KILKK++ILQD+DVE TM E+R+L+LA +HP+LT L+  FQT DRLFFVME+VNGGDLMF IQ+ RRF+E RA FY++E+T ALMFLH  GIIYRDLKLDN+LLD +GHCKLADFGMCKEG+     T+TFCGTPDYIAPEI+ E+ YG SVDWWALGVL+YEM++G  PFE +TE +LF +I  D V + S L   + DI+  FL K+P  RLGC   +GG++AI  H FF+++DW  L++R + PPF+P+++S  D +NFD DFT E+P LTPIE +
Sbjct:    6 LDMK-FNGYMRLRVGEAVDLKPTTFSTRHTLN---KKTHQLDPYIVVKVDDFKVGQTAIKPKTSRPAFNEEFCPYVSEGKELEIAVFHDTPIGYDDFVANCRIQLEDLLTSSSSRQSFEGWVNLEPVGSIYIYVSLTGS---------FTDGKLLYTHKELTRKRQRALRRKVHQVNGHKFMATFLKQPTFC----------------CHLCTCVVHKRCHHLVVSECPRMKKAEPS-----QGFSINLPHQFKVHNYKVPTYCNHCGSLLYGLVKQGLHCKGCKMNVHIRCEENVAPNCGVNSAQLASKLAEMGLQPSKL----------------------------TKSVSKVLYVKSEGQSEGIE-----------EECVKVGLDDFTFL------RV-------------------LGKGSFGKVM---------LARMNSSDRVFAVKILKKDIILQDDDVESTMIEKRVLSLAQQHPYLTHLYYCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFEEVRAQFYAAEITSALMFLHSKGIIYRDLKLDNVLLDKDGHCKLADFGMCKEGICNGVRTNTFCGTPDYIAPEIIQEEQYGVSVDWWALGVLLYEMLSGHAPFEAETEDELFESILRDEVIYSSWLSNEAEDILKGFLTKDPSCRLGCTERDGGEKAIAAHMFFKDLDWEKLKKRELEPPFKPRIKSFEDVNNFDLDFTQEEPTLTPIEEA 630          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDST--QKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            +++W+DL+P GK+ +S        +  SR  +    +   G    + R GA+++ ++H IK H+F  T FKQ TFCS+C  F+WGL  QGY+C+ C   +HK+C   +I RC G       +  Q  RF I++PH+F+ H +M P FCDHCGSLL+G+++QGL+CE C +N+H +C+  VA  CG+N K L EA+ +  L       +P         +I  +T    S+D   + +      PT P                 S S  ++T ++                                  +F F KVLGKGSFGKV+LAE K   + +A+K LKK+V+L D+DVECTM E+R+L+LA ++PFLT L+ +FQ+ + LFFVMEY+NGGDLMF IQ   RFD  RA FYS+E+   L FLH  G+IYRDLKLDN++LD +GH K+ADFGMCKE M G    +TFCGTPDYIAPEIL  Q Y FSVDWW+ GVL+YEM+ G  PF+GD E +LF +I  D   +P  +   S D++ K   ++P +RLG V +      I  H FF+ I+W  LE+R + PPF+PKV+S  D SNFD++F SE P L+  + +  I ++ +  F+GF F N
Sbjct:  100 AEFWVDLQPSGKVMMSVQFFVEDTDTESRPSVREKEED--GILTLNRRRGAIKQAKVHFIKNHEFTATFFKQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTVFQKERFKIDMPHRFKTHNYMSPTFCDHCGSLLWGMVKQGLKCEDCAMNVHHKCQTKVANLCGINQKLLAEALTQVSLKSSTKRPDPTLSDIGIYQDIAKNTPADPSADSNQYGKLWDGSTPTPP--------------AAPSASITHQTRIN--------------------------------FENFVFHKVLGKGSFGKVLLAELKGRGEYFAVKALKKDVVLMDDDVECTMVEKRVLSLAWENPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLFRATFYSAEIICGLQFLHSKGVIYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYTFSVDWWSFGVLVYEMLIGQSPFQGDDEDELFESIRMDVPHYPRWITKESKDLLEKLFERDPTRRLGVVGN------IRGHSFFKTINWPALEKREVPPPFKPKVKSPNDCSNFDREFLSEKPRLSHADKNL-IDSMDQTAFSGFSFIN 680          

Query: 2565 RAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKK-------CGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPC--------LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRAC--FYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKV 4190
            R GA+++ ++  +KGH F  T F Q TFCS+C  F+WGL  QG+QC+ C    HKRC  NV+ RC G  DT   +E     FN+++ H F+VH++  P FCDHCG+LL+G  RQGLQCEAC  N+H +C+  VA  CG++T+ L E +++       C              R+    +      K    P  ER    P+ + P +   T                       SVI   R+   +   +P+  Q   D    P         L  F+ +KVLGKGSFGKV+LAE K     +AIK LKKEV+L  +DVECTM E+R+L +A +HPFLT L  +FQT + LFFVME++ GGDLMF IQ   +FD P     FY++EV   L FLH H IIYRDLKLDN+LLD EGH K+ADFGMCKE +    L +TFCGTPDYIAPEIL  + YG SVDWW++GVL+YEM+ G  PF G  E +LF AI   +  +P  L  +S +I+S    ++  KRLG V        I  HPFF+ IDW  LE R+I PPF+PKV
Sbjct:    2 RRGAIKQAKVKFVKGHAFVTTFFPQPTFCSVCKEFVWGLNKQGFQCKECNASSHKRCVDNVLARCTGSADTNRQTEIVRESFNLHMSHSFKVHSYRSPTFCDHCGTLLWGFARQGLQCEACDANVHHKCKGKVANLCGISTERLAELLRQVEGGQVSCVGRRRGGAGRGILSRSLPEFDCISVETKEKGAPGAER----PVESQPPSRKAT----------------------RSVIFDQRAKGHLTPPQPAPPQSVPDESTRPSGEIAGKLSLDHFHLLKVLGKGSFGKVMLAELKEQGKFFAIKALKKEVVLMGDDVECTMVEKRVLLMACEHPFLTHLCGTFQTKEHLFFVMEFLTGGDLMFHIQDKGKFDLPTGTNRFYAAEVICGLQFLHSHNIIYRDLKLDNVLLDREGHVKIADFGMCKEHVGAGNLATTFCGTPDYIAPEILLGRAYGTSVDWWSMGVLIYEMLIGQSPFYGSDEDELFEAIKGHTPHYPRWLSDSSRNILSCLFERDHTKRLGAVGD------IRLHPFFKNIDWPSLEARKITPPFKPKV 529          

Query: 2499 LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLH-KHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTP 3419
            +++F+++K+LGKG+FGKVIL   K+T   YA+KILKKEVI+  ++V  T+TE R+L    KHPFLT L  SFQT DRL FVMEYVNGG+L F + R R F E R  FY +E+  AL +LH +  ++YRDLKL+N++LD +GH K+ADFG+CKEG++      TFCGTP+Y+APE+L + DYG +VDWW LGV+MYEMM G  PF     + LF  I  + + FP +L   +  ++S  L K+P +RLG    +  +  IMRH FF  I W  + +R++ PPF+P+V S TDT  FD++FT++   +TP
Sbjct:  147 MNNFDYLKLLGKGTFGKVILVREKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQ-TTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKE--IMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITP 451          

Query: 2559 KVILAEHKSTC-DVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRS 3371
            +V LAE KS   + +AIK LKK+V++  +DVECT+ E+RIL+LA  HP+L  L+S+FQT + L FVMEY+NGGDLMF IQ   RF+  RA FY++E+   L FLH  GIIYRDLKLDNILLD +GH K+ADFGMCKE + G     TFCGTPDYIAPEI+  Q Y  SVDWW+ GVL+YEM+ G  PF GD E++LF +I      +P  +   S DI+   L + P+KRLG          I +HPFFR I+W  LE+R + PPF+P+V S
Sbjct:    1 QVFLAELKSRPRNFFAIKALKKDVVIMSDDVECTLVEKRILSLAWGHPYLAHLYSTFQTKEHLMFVMEYLNGGDLMFHIQVKGRFEIDRATFYAAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCKENIVGDVRAGTFCGTPDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPFRGDDEEELFESIRTSVPYYPRWITKDSRDILPLLLEREPMKRLGVTGE------IRQHPFFRTINWEALEKRELEPPFKPRVVS 266          

Query: 2436 SDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENS-----CEIAALGKDVFAGFDFF 3416
            SDF+F+ VLGKGSFGKV+LA+HKS    YA+K++KK +ILQ ++ +  M E+ +L    +HPFL  LH SFQ+ D+L+FVM+YVNGG+L F +QR   F E RA FY++E+  A+ +LH   I+YRDLK +NILLD +GH  L DFG+CKEG+     T TFCGTP+Y+APE+L +  Y  +VDWW LG ++YEM+ G PPF     + ++ +I +  +        A++ ++   L K+P +RLG  +       I  H FF  I+W  L+ +RI  P+ P V    D  NFD  FT+E   ++  ++S     C       D F GF + 
Sbjct:   90 SDFDFLTVLGKGSFGKVLLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLGATS---DILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTSSVCANVDEAADAFVGFTYM 418          

Query: 3072 CVVHKRCYQNVIVRCPGVK----DTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDL----------GYNPRYERTSTSANITDSTQK-----------------SSDLPMHER------------------SLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLAL 4043
            CVVHKRC++ +I +CPG+K    D Y SS        +NVPHKF +H +  P FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE+NVAP CGV+ + + + + + G+ P  +             PR +    S ++    Q                  S  LP H R                  +L   + T  +       PV+  +   +G+   ++GV  ++     S  +   +   +        +   L DF+F+KVLGKGSFGKV+L E K T +V+A+K+LKK+ I+QD+DV+CT+TE+RILALA KHP+LT L  SFQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+  Y +EVT AL
Sbjct:    1 CVVHKRCHELIITKCPGMKKEAQDEYPSS--------VNVPHKFSIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCEQNVAPSCGVDARGIAKVLAEIGVTPDKIHQSTIKKKKPAIYPRNKTAQISISLVQGWQNLRSASHMRPPTDRLSPLSLQLPRHARWTRALFFTILISKLLLVPALGWWLLTQRNLGRFWPPPVSPPIHACTGAKELESGVKKALSFEAPSEGKAAENGEGAPPTTNRLCRRYGLDDFSFIKVLGKGSFGKVMLGELKGTDEVFAVKVLKKDSIIQDDDVDCTITEKRILALARKHPYLTQLFCSFQTRDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRVYGAEVTSAL 365          

Query: 2418 LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAK--HPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNI 3419
            L +F  +KVLGKG+FGKVIL++ K+T  + AIK+LKK+ I+Q+ D+E    E+++  LA K  HPFLT L+ SFQT++R++F ME++ GGDLM+ +Q  +R    RA FY++EV LAL + H +G+IYRDLKL+NILL  EGH K+AD+G+CK+ M     TSTFCGTP+++APEIL EQ+Y  +VDWWA GVL+Y+M+    PF GD E ++FNAI  D   +P  +    V I    L K+P KRLG    +  +  +M  PFFR I++  +   R++PP+ P+++S  DTS F+++FTS  P LTP+ +   +    ++ F GF F   D ++
Sbjct:  821 LDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQN-QRLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADE--VMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSV--LTTSQQEEFRGFSFMPDDLDL 1151          

Query: 3573 TSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQI---KGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTK---DLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS--TQKSSDLP---MHERSLSSPIPTHPDNYPITIEP 4334
            +++ W  LEP G++ ++  L   K  +I R++L      +GG H    R GA+  R  +I    GH F    F     C+ C  F   L   G+QCQ C  + HK+CY NV+ +C  +  T + ++    + N  +PH+F   +     +C HCG +L     +  +C  C +  H +C   V   CG++ +    +++ I+    N        + +RT  SA +  S  T   SDL    + ER+ ++P+P  P  +  T  P
Sbjct:  362 STNSWFVLEPSGQILLT--LGFHKSSQIERKQL------MGGLH----RHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDF---LRYTGFQCQDCKFLCHKKCYTNVVTKC--IAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSECGIMCHAQCAHLVPDFCGMSMEMANKILKTIQDTKRN------QEKKKRTVPSAQLGSSIGTANGSDLSPSKLAERA-NAPLPPQPRKHDKTPSP 602          

Query: 2388 CLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQ 3422
             + DF+ +KV+GKGSFGKV+    K T  +YA+K L+K  I+   +V  T+ E+ +LA     PF+  L  SFQ+ ++L+ V+ ++NGG+L + +Q   RF   R+ FY +E+  AL  LHK  +IYRDLK +NILLD +GH  L DFG+CK  M  +  T TFCGTP+Y+APEIL  Q Y  +VDWW LG+L+YEMM G PP+  +    ++  I    + FP    PA+ D++   L ++P +RLG      G   I  HPFF++I W  L  +   PP++P V+S  DT+NFD++FT E P+ + ++    ++A  +  F G+ +   +       G  PSQ
Sbjct:  340 SIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLA-RVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV----NGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEY--LSASIQKQFGGWTYIGDE-----QLGDSPSQ 672          

Query: 2508 CLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPV 3422
             + DF+ +KV+GKGSFGKV+    K T  VYA+K ++K  I+   +V  T+ E+ +LA     PF+  L  SFQ+ ++L+FV+ ++NGG+L + +Q+  RFD  RA FY++E+  AL  LHK  ++YRDLK +NILLD +GH  L DFG+CK  M     T TFCGTP+Y+APE+L    Y  +VDWW LGVL+YEM+ G PP+  +    ++  I  + + FP      + D++   L ++P +RLG      G   I  HPFF ++ W  L  +   PP++P V +  DTSNFD++FT E P+
Sbjct:  343 SIDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLA-RVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGY----NGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPI 642          

Query: 2532 CLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRT-DTSNFDK 3422
             L DF  ++ LG GSFG+V L         YAIK+LKK+ +++ + VE T  E+R+L L  +HPFL  +  +FQ    +F VM+Y+ GG+L   +++ +RF  P A FY++EV LAL +LH H IIYRDLK +NILLD  GH K+ DFG  KE  +   +T T CGTPDYIAPE++  + Y  SVDWW+LGVL+YEM+AG  PF   T    +  I    V +P    P  VD++SK +  +  +R+G +  + G + I  HP+F E+ W  L  + I  P+ P + S   DTS FD+
Sbjct:   66 TLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLV-EHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQT---VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNL--QSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQ 357          

Query: 2532 SLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVD--DSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRS-RTDTSNFDK 3629
            S+++   T PDN    I PVN   V    S+     ++  +S  L + +S  +   +   LQ Y DT     LSDF  ++ LG GSFG+V L         YA+K LKK  I++ + VE T  E+R+L++ + HPF+  +  +FQ   ++F VM+Y+ GG+L   +++ +RF  P A FY++EV LAL +LH   IIYRDLK +NILLD  GH K+ DFG  K       +T T CGTPDYIAPE+++ + Y  SVDWW+ GVL+YEM+AG  PF        +  I    + FP    P + D++ K + ++  +RLG +  + G + +  HP+F E+ W  L  R I  P+ P ++  + DTS FD+
Sbjct:   15 SITAKTETTPDNVGQDI-PVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLVKKPMLQ-YRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVS-HPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNL--QNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDR 375          

Query: 2424 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESI--ESTSDYWLDLEPEGKLRISCILNGSKI-------EEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVK---DTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDY 4658
            M  F+GS+ ++I EA ELK  A A    V  T      +DPY++V+VD+  + ++++K K   P W++E   +V +G  + F V+H+A +PP  FIA    S E +    +S+ W+ LEP G++ ++  L  S         +E    K +PG        G + R GA+RRRIHQI  HKF  T  +Q TFCS CN FIWG +  QGYQCQVCTCVVHKRC++ V+ +CPG +   +T       L RF ++VPHKF   ++ RP FC+ CGSLL+G++RQG+QC  CK+N+H+RC +NVA +CG+N K + E +++ G++P  +    +  +  +  + T+   K     M  RS+SSP                     +   + N+ G+  S         ++ SH+ S  +      +   L DF F+KVLGKGSFGKV+LAE K T +VYAIKILKKE +LQD+DVECTM E+R+LAL+A HPFLT+LHSSFQT +RLFFVMEYVNGGDLMFQIQ+ R+FDE R+ FY++EV LAL FLH++G+IYRDLKLDN+LLDA+GH KLADFGMCKE M+  K T+TFCGTPDYIAPEIL EQ YGFSVDWWALGVLMYEMMAG PPFE + E+DLF +I +D V +P  L   +V I+  F+ KN LKRLGC      + +I  H FFR I++  LE R+I PPF+PK+RSRTD  NFD DFT E+P LTP + +  I  + +  F GF F N  +
Sbjct:    1 MVGFTGSLKLRIFEAIELKPAAKA-HWGVKLTT-----IDPYLLVKVDDVQIAQTTSKTKTFTPVWNEEFIVEVENGRDLEFAVFHNAIMPPKPFIANTTVSLEEVIKSGSSEIWIPLEPHGQVHVNIELKPSNTAHQHYHDKEQRVFKENPG--------GINRRRGAMRRRIHQINSHKFMATYLRQPTFCSHCNDFIWGVIGKQGYQCQVCTCVVHKRCHKMVVTKCPGTRQDAETMPLGGGSL-RFKMDVPHKFEKKSYNRPTFCELCGSLLYGIVRQGMQCTVCKMNVHRRCHQNVANNCGINPKKMAEILEEIGISPDRIHEESQQIKKPSFHDCTNKPAKK----MTPRSVSSP---------------------SMMESVNENGLPGSTF-------KLESHQTSPGERRRHVLRKMTLKDFTFIKVLGKGSFGKVLLAERKGTDEVYAIKILKKESVLQDDDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMAPGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTP-TSTESSIREHAFFRLINFEKLEARQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPTDRNV-IVNIDQREFRGFSFVNPHF 709          

Query: 2823 PHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCG---------VNTKDLVEAIKKCGLNPLDL-GYNPRYERTSTSANITDSTQKSSDL------PMHERSLSSPIPTHPDNYPITIEPVN-----------------------------KCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAG 3935
            PH F  HT+  P FCDHCGSLL+G+  QGL+C AC +N+HK+CEK V   CG         ++ K   E  +   L P+D  G +  Y +     +  ++++K + +      P+   +    I     +  ++IE  +                             K L    G   N   +DD+    +R  ++ +    S        P+     DF+F+KVLGKGSFGKV+LAE K T  VYAIK+LKK+VI+QD+DVECTMTE+R+LA+  K PFLT L   F + DRL+FVME+VNGGDLMF IQ+  RF EP+A FY++E+ + L+FLHK GI+YRDLKLDN++LD++GH K+ADFGMCKE M  ++ T TFCGTPDYIAPEI+A Q YGFSVDWWALGVL+YEM+AG
Sbjct:    2 PHNFGPHTYKSPCFCDHCGSLLYGVYHQGLKCTACDMNVHKKCEKAVPKLCGADHTERRGRIHLKISYELREARNLMPMDPNGLSDPYVKVKLLPDPDNTSKKKTKIFKESLSPVFNETFEFKIQNKDKDRRLSIEVWDWDRTTRNDFMGSLSFGVSELQKNGVEGWFKLLSQEEGEYYN-IPIDDAREEEERKCRQKLEQSLSDPNAKKFRPE-----DFHFLKVLGKGSFGKVMLAERKGTDQVYAIKVLKKDVIVQDDDVECTMTEKRVLAVPGKPPFLTQLFCCFHSVDRLYFVMEFVNGGDLMFHIQQAGRFKEPQAVFYAAEIVIGLVFLHKRGIVYRDLKLDNVMLDSDGHIKIADFGMCKESMFNNQTTRTFCGTPDYIAPEIVAYQPYGFSVDWWALGVLIYEMLAG 411          

Query: 2433 LSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPF---------EGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 3419
            ++DFN ++V+G+GS+ KV+L E K T  +YA+K++KKE++  DED++   TE+ +   A+ HPFL  LHS FQT  RLFFV+EYV+GGDLM+ +QR RR  E  A FYS+E+  AL FLH+ G+IYRDLKLDN+LLD++GH KL D+GMCKEG+    +TSTFCGTP+YIAPEIL  +DYGFSVDWWALGVL+YEM+AG  PF         + +TE  LF  I    +  P SL   +  I+  +L KNP +RLGC    G    I  H FFR + W  LE R++ PPF+P+        NFD  FT+ED   TP ++   +  + +  F GF++ N
Sbjct:  219 VNDFNLIRVIGRGSYAKVMLVELKKTKRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTSSRLFFVIEYVSGGDLMYHMQRQRRLPEDHARFYSAEICCALNFLHEKGVIYRDLKLDNVLLDSDGHIKLTDYGMCKEGIRPGDVTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDIVGSADNPDQNTEDYLFQVILEKPIRIPRSLSVKAASILKGYLNKNPTERLGCHPQTGFAD-ITSHAFFRTVSWEQLEARQVTPPFKPRQEDPYGLENFDPQFTNEDVQFTP-DDPKMLETIDQTEFEGFEYIN 554          

Query: 3999 YRAGALR-RRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRC 4193
            YR GA R R+IH + GH F    F +   C+ C+  IWGL   GY+C  C  VVHK+C++ + ++C
Sbjct:  107 YRRGAKRWRKIHIVNGHSFVAKRFSRLAACAFCSDRIWGLGRSGYKCLECKLVVHKKCHKLIKIQC 172          

Query: 3780 CPG-VKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCG 4001
            C G  ++ Y     +  + +I   H F    F R A C  C   ++GL R G +C  CKL +HK+C K +   CG
Sbjct:   99 CNGETRNIYRRGAKRWRKIHIVNGHSFVAKRFSRLAACAFCSDRIWGLGRSGYKCLECKLVVHKKCHKLIKIQCG 173          

Query: 2439 SDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGK------DVFAGFDF 3416
            SDF F+KV+GKGSFGKV L+++K     YAIK+L K  I +  + +  M E+ +L     HPFL  LH SFQT D+L+FV++YVNGG+L F +QR R F E RA FY++E+  A+ +LH   IIYRDLK +NILLD++GH  L DFG+CKEG+  S  TSTFCGTP+Y+APE+L +QDY  SVDWW LG ++YEMM G PPF      ++++ I +  +   +++  ++  I+   L K+  KRLG  + EG  + I  H FFR I+W  L  R I PP+ P V  + D  +FD +F  E PV   +  S +   +        D F GF +
Sbjct:   72 SDFLFLKVIGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLG--SGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFDPEFVRE-PVPGSVGKSADSNFVSASVDDPDDAFVGFTY 400          

Query: 2439 CLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAK--HPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEIL-AEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDF 3422
             +S+F  + VLG+G FGKVILAE+++T +++AIK LKK  I+  E+VE  + E+RI   A K  HPFL  L + FQT + + FVMEY  GGDLM  I     F E R  FY++ V L L +LH H I+YRDLKLDN+LLD+EG+ K+ADFG+CKE M     T TFCGTP+++APE+L  E  Y  +VDWW LGVL++EM+ G  PF GD E+++F++I  D V +P  L   ++ I+ + L +NP +RLG  A E   + + + PFFR++ W  L  R+IRPPF P+V+   D SNFD++FTSE+P+LTP + +  +    + +FA F++
Sbjct:  608 SMSNFRCISVLGRGHFGKVILAEYRNTNELFAIKALKKGDIIAREEVESLLAEKRIFLTANKTRHPFLVNLFACFQTQEHVCFVMEYAPGGDLMMHIH-ADVFAESRTVFYTACVVLGLQYLHDHEIVYRDLKLDNLLLDSEGYVKIADFGLCKEDMGYGARTGTFCGTPEFLAPEMLVTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAIAIMRRLLRRNPERRLG--AAEKDAEEVKKQPFFRDMRWDDLLARKIRPPFVPQVKHAEDVSNFDEEFTSEEPILTPPKEARSLNPDEQGLFADFNY 935          

Query: 2439 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTS----DYWLDLEPEGKLRISCILNGSKIE-------EISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVK--DTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHP-DNYPITIEPVNKCLVLN-----------------SGSNCN----KTGVDDSVILGDRSSKRVISHRPSSLQEYGDT--PKVP-----CLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDF 4658
            M  F+G + +KI EA +LK TA + RHAVGP  + F  LD Y+ + VD+  VG++STK K N+P W+DE + +V  G  I  +V+HDA I  DDF+A     FE I        + W+DLEPEGK+ +   L GS  E        + R+++ P             R GA+RRR+HQ+ GHKF  T  +Q T+CS C  FIWG L  QGYQCQVCTCVVHKRC++ +I +C G+K  D          RF++NVPH F +H F    FCDHCGSLL+GL+RQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P  +  + +  +       T   Q+S      E   S   PT P D     +E + K L  +                 +   C+    + G +++   GD              QE G+   P  P      L DF F+KVLGKGSFGKV+LAE K T +V+A+K+LKK+VILQD+DV+CTMTE+RILALA KHP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDE R+ FY++EVT ALMFLH+HG++YRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E DYG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ K+P KRLGCVA +G ++AI  HPFFREIDW LLEER+++PPF+P+++++ D +NFD+DFT E+PVLTP++++  +  + +D F GF +
Sbjct:    1 MVVFNGQLRIKICEALDLKPTAWSLRHAVGPKTQTFL-LDTYIALNVDDSRVGQTSTKQKTNSPTWNDEFTTEVHDGRRIELSVFHDAPIGYDDFVANCIIQFEDILHNGSKHLEEWIDLEPEGKVYVVIDLIGSSSEVSSENEERVFRQRMRP-----------RKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGMKKQDNTVGEPVGSQRFSVNVPHMFSIHNFKVLTFCDHCGSLLWGLLRQGLQCKVCKVNVHRRCESNVAPNCGVDARGIAKVLSDLGVTPDKISNSAQRRKKLPQ---TQDAQQSLSEAQTEDDRSKSAPTSPCDQDVKELENIRKALSFDHRGEELTTLPLSSSSSIATVTCDTHEGEGGAEENSAGGDAEGS----------QENGEVKGPSAPETKRMNLHDFVFIKVLGKGSFGKVMLAELKGTDEVFAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHRHGVVYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELDYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILRAFMTKSPSKRLGCVAAQGLEEAIKVHPFFREIDWTLLEERKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVDDTI-VKQINQDEFKGFSY 757          

Query: 2439 FSGSVTVKIIEAKELKATACATRHAV----GPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDY------WLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLW-NQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNR-FNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCL--SDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDF 4649
            F+G + ++I EA +LK T  +TRH+V     P A     LDPY++V+VDE  +G++ TK K N P +++E   +V  G  I   V+HD  +  DDF+A     FE +  T +       W+DLEPEGK+ ++  LNGS  ++ +   +    Q          R GA+RRRIHQ+ GHKF  T  +Q TFC  C  FIWG++  QGYQCQ+CTCVVHKRC+Q V+  CP +K T  + +  +N+ F+INVPHKF  H +  P FCDHCGSLL+G++RQGL C+ CK+N+H RC+ NVAP+              CG+N ++L         +T A +                                        L +G    +  +  +        +RV S R  S        ++P L  S+F F++VLGKGSFGKV+LA+      V+A+K+LKK++ILQD+DVECTMTE+R+L+LA  HP+LT L+  FQT DRLFFVME+VNGGDLMF IQ+ R+FDEPRA FY++E+T ALMFLH  GIIYRDLKLDN+LLD +GHCKLADFGMCKE +     T TFCGTPDYIAPEIL E  YG SVDWWALGVL+YEM++G  PFE + E DLF +I  + + + S L   +VDI+   L KNP +RLGCVA EGG+ A+  H FF  IDW  L  R + PPF+P++++  D +NFD DFT E+P LTPI+    I ++ ++ F  F F
Sbjct:    3 FNGYLKLRIGEALDLKPTTASTRHSVIFNKAPLA-----LDPYMVVKVDEYKIGQTHTKQKTNQPTYNEEFCMNVNDGKQIELAVFHDTPLGYDDFVANCIIQFEDLIKTINTGENFEEWMDLEPEGKVYVTITLNGSFTDDDAVTTVKTPKQFTRA------RQGAVRRRIHQVNGHKFMSTFLRQPTFCFHCKEFIWGVFGKQGYQCQICTCVVHKRCHQLVVTVCPRMKKT--AKDQPINQGFSINVPHKFNHHNYKSPTFCDHCGSLLWGIVRQGLHCKICKMNVHIRCQGNVAPN--------------CGVNSVELA--------NTLAEMG---------------------------------------LQAGGLSKRNTIVKNATNSQSEKQRVSSERRESTTSTESRQQMPRLGISNFTFLQVLGKGSFGKVMLAKLNGKERVFAVKVLKKDIILQDDDVECTMTEKRVLSLARCHPYLTELYCCFQTPDRLFFVMEFVNGGDLMFHIQKSRKFDEPRARFYTAEITSALMFLHSKGIIYRDLKLDNVLLDQDGHCKLADFGMCKENIFEGAATGTFCGTPDYIAPEILQEMMYGASVDWWALGVLLYEMLSGHAPFEAENEDDLFESILNEEIVYASWLSTEAVDILKALLTKNPARRLGCVAAEGGECAVTSHVFFTGIDWEKLNNREMEPPFKPRIKTPEDVNNFDPDFTHEEPTLTPIDGPV-IPSVNQEEFRNFSF 678          

Query: 2433 SDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITI-EPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            +++W+DL+P GK+ ++       ++  S++ +             + R GA+++ +IH IK H+F  T F+Q TFCS+C  F+WGL  QGY+C+ C   +HK+C   +I RC G       +  Q  RF I++PH+F+ + +M P FCDHCGSLL+GL++QGL+CE C +N+H +C+K VA  CG+N K L EA+                         T  +QKSS      R     +P  PD   I I + VNK     +G   N       +  G        S RP S   +     V    +F F KVLGKGSFGKV+LAE K + + +A+K LKKEV+L D+DVECTM E+R+LALA ++PFLT L+S+FQT + LFFVMEY+NGGDLMF IQ   RFD  RA FYS+E+   L FLH  GIIYRDLKLDN++L+ EGH K+ADFGMCKE + G    +TFCGTPDYIAPEIL  Q Y FSVDWW+ GVL+YEM+ G  PF GD E +LF +I  D+  +P  +   + D++ +   + P  RLG V +      I +H FF+ I+W  LE R + PPF+PKV++  D SNFD++F SE P L+  + +  I ++ +  F+GF F N
Sbjct:  125 AEFWVDLQPSGKVMMAVQYFLEDVDAESKQAVKEEEAPT-----LNRRRGAIKQAKIHFIKNHEFIATFFRQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTVFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCAMNVHHKCQKKVANLCGINQKLLAEAL-------------------------TQVSQKSS-----TRRSDPNLPPMPD---IGIYDEVNKL----AGLELNDASPYGRLWEG-------CSPRPQSRITHLTRINV---DNFIFHKVLGKGSFGKVLLAELKGSGEYFAVKALKKEVVLMDDDVECTMVEKRVLALAWENPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLNRATFYSAEIVCGLEFLHSKGIIYRDLKLDNVMLNHEGHIKIADFGMCKEDVFGDNRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLVGQSPFHGDDEDELFESIRMDTPHYPRWINKEAKDLLEQLFDREPTHRLGVVGN------IRQHSFFKTINWQALERREVEPPFKPKVKAPNDCSNFDREFLSEKPRLSQSDKNF-IDSMDQSAFSGFSFIN 700          

Query: 2433 SDYWLDLEPEGKLRISC---ILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 4331
            +++W+DL+P GK++++    + +G  +      K    T ++        R GA+R+ +IH IK H+F  T F Q TFCS+C  F+WGL  QGY+C+ C   +HK+C   +I  C G       +  Q  RF I++PH+F+ + +  P FCDHCGSLL+GL +QGL+CEAC +N+H  C   VA  CGVN K L EA+ +  ++          +++S  +  ++S  +  D+ +++           D    T++P        +  + NKT                ++H                     F KVLGKGSFGKV+LAE +     +A+K+LKK V+L D+DVECTM E+R+LALA ++PFLT L+S+FQ+++ LFFVMEY+NGGDLMF IQ   RFD  RA FY++E+ + L FLH  GI+YRDLKLDNI+LD +GH KLADFGMC+E +S     STFCGTPDYIAPEIL  Q Y FSVDWW+ GVL+YEM+ G  PF+GD E +LF AI  D+  +P  +   S +++ +  IK+P+ R+  V +      I  H FF+ I+W  LE+R++ PP++PKV+S +D SNFD++F +E P L+  + +  + ++  + FAGF F N
Sbjct:  102 NEFWVDLQPSGKVQMAVQFFLEDGDIVATTQSVKPEEETYTLP------RRRGAVRQPKIHIIKNHEFIATFFNQPTFCSVCKEFVWGLNKQGYKCKQCNAAIHKKCKDKIIYNCTGTAANSRETMFQKERFKIDMPHRFKAYNYKSPTFCDHCGSLLWGLYKQGLKCEACSMNVHFNCNSKVANLCGVNQKLLAEALSQLTVS----------QKSSKKSQGSESEAEVPDVGIYQ-----------DVKTTTVDP--------NADDKNKTPTPSPTPSPAPQLHLTLNH-------------------LVFHKVLGKGSFGKVLLAELRGKGQFFAVKVLKKHVVLMDDDVECTMVEKRVLALAWENPFLTHLYSTFQSNEHLFFVMEYLNGGDLMFHIQDKGRFDITRATFYAAEIVVGLNFLHSRGIVYRDLKLDNIMLDCDGHIKLADFGMCRENISQENRASTFCGTPDYIAPEILLGQKYTFSVDWWSFGVLVYEMLIGQSPFQGDDEDELFEAIRTDTPHYPRWITKDSKNLLEQLFIKDPITRMSVVGN------IRLHSFFKSINWTALEKRQVEPPYKPKVKSPSDCSNFDREFLNEKPHLSKCDKNL-VESMDCNAFAGFSFIN 677          

Query: 2439 TFMR-PAFCDHCGSLLFGLM-RQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNY--------------PITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRS-SKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDF 3914
            T++R P +C HC   ++G++ +QG QC+                                        Y  R  R++ S NI  S + S ++P      +  +PT  D+                +    V++    N   NC       + +L D   +   IS+     ++     +   L DF+F+KVLGKGSFGKV+LAE K T +VYA+K+LKK+VILQD+DV+CT+TE+RILALA +HP+LT L+  FQT DRLFFVMEYVNGGDLMFQIQR R+FDEPR+ FY++EVT ALMFLH++G+IYRDLKLDNILLDAEGHCKLADFGMCKEG+     T+TFCGTPDYIAPEIL E +YG SVDWWALGVLMYEMMAG PPFE D E DLF +I +D V +P  L   +V I+  F+ KNP KRLGCV  +G ++AI  H FFREIDWVLLE+R+++PPF+P++  R D +NFD+DFT EDPVLTP + +  I  + ++ F  F +
Sbjct:    3 TYLRQPTYCSHCRDFIWGVLGKQGYQCQG--------------------------------------EYFSR-ARSNFSGNIVGSQRFSVNMPHKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLSDMGVTPDKISNTAQRRRKENGQSQRRNLKDFSFIKVLGKGSFGKVMLAELKGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARRHPYLTQLYCCFQTRDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHRNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGASVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKDAVSILRAFMTKNPSKRLGCVVSQGCEEAIKTHAFFREIDWVLLEQRKVKPPFKPRITKR-DVNNFDQDFTKEDPVLTPTDETI-IRQINQEEFKDFSY 470          

Query: 3729 VTLFKQFTFCSLCNSFIWG-LWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNP 4136
             T  +Q T+CS C  FIWG L  QGYQCQ                R    +  +S +     RF++N+PHKF +H +  P FCDHCGSLL+GLMRQGLQC+ CK+N+H+RCE NVAP+CGV+ + + + +   G+ P
Sbjct:    2 ATYLRQPTYCSHCRDFIWGVLGKQGYQCQ-----------GEYFSR---ARSNFSGNIVGSQRFSVNMPHKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLSDMGVTP 124          

Query: 3999 HKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRC 4148
            HKF +  +K  TFC  C S +WGL  QG QC+VC   VH+RC  NV   C
Sbjct:   57 HKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCETNVAPNC 106          

Query: 2361 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMNIPSN 4658
            MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGKSSTKNKNNNPKWSDEISFDVTHGCIITFTVYHDAAIPPDDFIAIADKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLP+HERSLSSPIPTHPDNYPITIEPVNKCLVLNSG               DRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMNIPSN
Sbjct:    1 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGKSSTKNKNNNPKWSDEISFDVTHGCIITFTVYHDAAIPPDDFIAIADKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPIHERSLSSPIPTHPDNYPITIEPVNKCLVLNSG---------------DRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYNIFRHHGIRPSQQQPMNIPSN 751          

Query: 2532 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDDSVILGDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDK 4658
            MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGKSSTKNKNNNPKWSDEISFDVTHGCIITFTVYHDAAIPPDDFIAIADKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLP+HERSLSSPIPTHPDNYPITIEPVNKCLVLNS               GDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDK
Sbjct:    1 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGKSSTKNKNNNPKWSDEISFDVTHGCIITFTVYHDAAIPPDDFIAIADKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPIHERSLSSPIPTHPDNYPITIEPVNKCLVLNS---------------GDRSSKRVISHRPSSLQEYGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDK 694          

Query:   22 MVFKGSXXXXXXXXXXXXXXXXXXSGETFKKSILIKEKRYELLGLTLNIYGKTIDHFARIPYALPPINNLRFKYPQEIVGNQWKGVYNATTSPNTCWQVEGGEFDKLNPAARLWLSKTPMSEDCLYLTIWSPRTVKTKLPVMVWIYGGSFFSGSSTLEVYDGSILAAKHEVVVVSLQYRLGPLGFLYLDDTLAPGNQGLMDQRMALKWVKDNIYNFNGDSESITIFGESAGSVGVSIHVLSPLSNNLFKRAIMESATASAAWAIETKKESKEKGLAISKFVNCNYDSWQVNVLLKCLQKVKPDLLVSKQLDLKNIVNKQRSDLLRRRGVKNLXXXXXXXXXXXXRPTYDANFINQPVNLLLNDSTFKPNIELLMGYNANEGMFFLLYGLNKWLNFFNKGEVEDTSLLSSNNTNYIKASKFLLENLTPNDIAYTNLLPLLLHEYKIPSTIFNWKKWNSTDVLSALDQLTGDQNFVCPVIDYAELLADKNVKVYLYSFQHRTSRMTFPKWTGTMHGYEIEYVFGMPFSKNFQNLFYTFTTEEAKLSNYIMTLWANFAKFGNPTTQKIEYFDSTLSWPLYNTTSKLSVYFTTPHESQLNAARLNDKAMKCKFWNKVIPPILEKFKNFSPTLNKVAWT 1923
            MVFKGSLLIIKLIFIY IIYI SISGETFKKSILIKEKRYELLGLTLNIYGKTIDHFARIPYALPPINNLRFKYPQEIVGNQWKGVYNATTSPNTCWQVEGGEFDKLNPAARLWLSKTPMSEDCLYLTIWSPRTVKTKLPVMVWIYGGSFFSGSSTLEVYDGSILAAKHEVVVVSLQYRLGPLGFLYLDDTLAPGNQGLMDQRMALKWVKDNIYNFNGDSESITIFGESAGSVGVSIHVLSPLSNNLFKRAIMESATASAAWAIETKKESKEKGLAISKFVNCNYDSWQVNVLLKCLQKVKPDLLVSKQ DLKNIVNKQRSDLLRRRGVKNLFTDASFFFDIFFRPTYDANFINQPVNLLLNDSTFKPNIELLMGYNANEGMFFLLYGLNKWLNFFNKGEVEDTSLLSSNN NYIKASKFLLENLTPNDIAYTNLLPLLLHEYKIPSTIFNWKKWNSTDVLSALDQLTGDQNFVCPVIDYAELLADKNVKVYLYSFQHRTSRMTFPKWTGTMHGYEIEYVFGMPFSKNFQNLFYTFTTEEAKLSNYIMTLWANFAKFGNPTTQKIEYFDSTLSWPLYNTTSKLSVYFTTPHESQLNAARLNDKAMKCKFWNKVIPPILEKFKNFSPTLNKVAWT
Sbjct:    1 MVFKGSLLIIKLIFIYSIIYIKSISGETFKKSILIKEKRYELLGLTLNIYGKTIDHFARIPYALPPINNLRFKYPQEIVGNQWKGVYNATTSPNTCWQVEGGEFDKLNPAARLWLSKTPMSEDCLYLTIWSPRTVKTKLPVMVWIYGGSFFSGSSTLEVYDGSILAAKHEVVVVSLQYRLGPLGFLYLDDTLAPGNQGLMDQRMALKWVKDNIYNFNGDSESITIFGESAGSVGVSIHVLSPLSNNLFKRAIMESATASAAWAIETKKESKEKGLAISKFVNCNYDSWQVNVLLKCLQKVKPDLLVSKQFDLKNIVNKQRSDLLRRRGVKNLFTDASFFFDIFFRPTYDANFINQPVNLLLNDSTFKPNIELLMGYNANEGMFFLLYGLNKWLNFFNKGEVEDTSLLSSNNPNYIKASKFLLENLTPNDIAYTNLLPLLLHEYKIPSTIFNWKKWNSTDVLSALDQLTGDQNFVCPVIDYAELLADKNVKVYLYSFQHRTSRMTFPKWTGTMHGYEIEYVFGMPFSKNFQNLFYTFTTEEAKLSNYIMTLWANFAKFGNPTTQKIEYFDSTLSWPLYNTTSKLSVYFTTPHESQLNAARLNDKAMKCKFWNKVIPPILEKFKNFSPTLNKVAWT 634          

Query: 2421 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREK-----------------------------------------------LSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDD---------SVILGDRSSKRVISHRPSSLQEYGDT--------PKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVA---------HEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYN 4658
            M YF+G++T++IIEA ELKAT  A RHAVGP AKL+E LDPYV +E+DE + GK+STK+K  NPKW++E++ DV +G  ITFTVYHDAAIPPDDFIA    SF+ ++S   + +DLEP+GKL       GS  EE ++++                                               L+      G    +H R GA+R+ R+HQ KGHKF VT+FKQFTFCSLC  FIWGLW QGYQC VCTCV+HKRC  N+I  CPGVK++  + E QL RF+INVPH F  H +  P FCDHCGSLLFG +RQGLQC+ CKLNIHKRCEKNVA HCGV TK LVE ++ CGL+P DL   PR     T  NIT+ T  +     H+  L S                N    L +   C    ++D         +V+   R S       PS ++   D+        PK   LSDFN + VLGKGSFGKV+L E KST +V+A+K LKK+VILQD+DV+CT+TE+RILALAAKHPFLTALHSSFQT DRLFF+ME+VNGGDLMF IQ+ RRFDEPRACFYS+EV LAL FLH                   GHCKLADFGMCKEG+SG K T+TFCGTPDYIAPEI+ E+ Y FSVDWWA+GVLMYEMMAGAPPFEG +E +LF AI  D V FPS+L  A+ D++SKFL K P +RLGC           ++ G + I +H F+R++DW  LE+R++ PPF+P V S +DTSNFD+DFT+E P LTP+++ C +  + +  F GF F N DY+
Sbjct:    1 MVYFNGTLTIRIIEALELKATDWAKRHAVGPAAKLYEVLDPYVTIEIDEFLFGKTSTKHKTFNPKWNEELNGDVRNGQFITFTVYHDAAIPPDDFIANCSVSFDYVKSNKSFRVDLEPDGKLDFYIDFKGSLSEEPTKDRGRLSVTCNSGSSNSNKCSLQSNNCSTTSIRPTVIITISGSNKTPQDSLANSNVQSGPVISRHNRRGAMRKQRVHQTKGHKFMVTMFKQFTFCSLCKEFIWGLWYQGYQCHVCTCVIHKRCLSNMITWCPGVKESSRNEENQLARFSINVPHHFHPHNYKWPTFCDHCGSLLFGFIRQGLQCKVCKLNIHKRCEKNVAKHCGVKTKMLVERMQACGLSPADL--EPR----RTQPNITE-TPYTPTFSKHDSGLMS---------------CNSSTQLATMETCRSASLEDPPLEKLSPNTVVSVKRRSVERSHSTPSGIRGKEDSLSQLAALAPKSYKLSDFNMLSVLGKGSFGKVMLVELKSTGEVFALKALKKDVILQDDDVDCTLTERRILALAAKHPFLTALHSSFQTPDRLFFIMEFVNGGDLMFHIQKARRFDEPRACFYSAEVALALHFLH------------------NGHCKLADFGMCKEGISGDKTTTTFCGTPDYIAPEIILEESYDFSVDWWAMGVLMYEMMAGAPPFEGSSEDELFKAILSDKVMFPSNLSLATADLISKFLTKRPQQRLGCAVNSNIPSSERYKKGFKDIQQHTFYRDLDWRKLEQRQLTPPFKPLVCSNSDTSNFDRDFTNEQPKLTPVDSEC-VKHIDQREFRGFSFVNPDYS 779          

Query: 2421 LRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRR-RIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCGVNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDSTQKSSDLPMHERSLSSPIPTHPDNYPITIEPVNKCLVLNSGSNCNKTGVDD---------SVILGDRSSKRVISHRPSSLQEYGDT--------PKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPFEGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVA---------HEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFNTDYN 4295
            +R + I+  S   +  ++ L+      G    +H R GA+R+ R+HQ KGHKF VT+FKQFTFCSLC  FIWGLW QGYQC VCTCV+HKRC  N+I  CPGVK++  + E QL RF+INVPH F  H +  P FCDHCGSLLFG +RQGLQC+ CKLNIHKRCEKNVA HCGV TK LVE ++ CGL+P DL   PR     T  NIT+ T  +     H+  L S                N    L +   C    ++D         +V+   R S       PS ++   D+        PK   LSDFN + VLGKGSFGKV+L E KST +V+A+K LKK+VILQD+DV+CT+TE+RILALAAKHPFLTALHSSFQT DRLFF+ME+VNGGDLMF IQ+ RRFDEPRACFYS+EV LAL FLH                   GHCKLADFGMCKEG+SG K T+TFCGTPDYIAPEI+ E+ Y FSVDWWA+GVLMYEMMAGAPPFEG +E +LF AI  D V FPS+L  A+ D++SKFL K P +RLGC           ++ G + I +H F+R++DW  LE+R++ PPF+P V S +DTSNFD+DFT+E P LTP+++ C +  + +  F GF F N DY+
Sbjct:  206 IRPTVIITISGSNKTPQDSLANSNVQSGPVISRHNRRGAMRKQRVHQTKGHKFMVTMFKQFTFCSLCKEFIWGLWYQGYQCHVCTCVIHKRCLSNMITWCPGVKESSRNEENQLARFSINVPHHFHPHNYKWPTFCDHCGSLLFGFIRQGLQCKVCKLNIHKRCEKNVAKHCGVKTKMLVERMQACGLSPADL--EPR----RTQPNITE-TPYTPTFSKHDSGLMS---------------CNSSTQLATMETCRSASLEDPPLEKLSPNTVVSVKRRSVERSHSTPSGIRGKEDSLSQLAALAPKSYKLSDFNMLSVLGKGSFGKVMLVELKSTGEVFALKALKKDVILQDDDVDCTLTERRILALAAKHPFLTALHSSFQTPDRLFFIMEFVNGGDLMFHIQKARRFDEPRACFYSAEVALALHFLH------------------NGHCKLADFGMCKEGISGDKTTTTFCGTPDYIAPEIILEESYDFSVDWWAMGVLMYEMMAGAPPFEGSSEDELFKAILSDKVMFPSNLSLATADLISKFLTKRPQQRLGCAVNSNIPSSERYKKGFKDIQQHTFYRDLDWRKLEQRQLTPPFKPLVCSNSDTSNFDRDFTNEQPKLTPVDSEC-VKHIDQREFRGFSFVNPDYS 816          

Query: 3783 MKYFSGSVTVKIIEAKELKATACATRHAVGPTAKLFENLDPYVIVEVDERIVGXXXXXXXXXXXXXSDEISFDVTHGCIITFTVYHXXXXXXXXXXXXXDKSFESIESTSDYWLDLEPEGKLRISCILNGSKIEEISREKLSPGTQSIGGFHGKHYRAGALRRRIHQIKGHKFQVTLFKQFT-----------FCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRCPGVKDTYSSSEAQLN-------------------RFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHC 4658
            M YF+G++T++IIEA ELKAT  A RHAVGP AKL+E LDPYV +E+DE + GK+STK+K  NPKW++E++ DV +G  ITFTVYHDAAIPPDDFIA    SF+ ++S   + +DLEP+GKL       GS  E+           S+      H R       +   KG  +++ L K FT               CNS          Q   C+    +     VI+   G   T   S A  N                   R +    HKF V  F +  FC  C   ++GL  QG QC  C   IHKRC  N+   C
Sbjct:    1 MVYFNGTLTIRIIEALELKATDWAKRHAVGPAAKLYEVLDPYVTIEIDEFLFGKTSTKHKTFNPKWNEELNGDVRNGQFITFTVYHDAAIPPDDFIANCSVSFDYVKSNKSFRVDLEPDGKLDFYIDFKGSLSED-----------SVIFPRNNHLRTNKPWSFLR--KGLCWEI-LIKHFTSTLQPTKDRGRLSVTCNSGSSNSNKCSLQSNNCSTTSIR---PTVIITISGSNKTPQDSLANSNVQSGPVISRHNRRGAMRKQRVHQTKGHKFMVTMFKQFTFCSLCKEFIWGLWYQGYQCHVCTCVIHKRCLSNMITWC 305