Protein lifeguard 1

Overview


Name	Protein lifeguard 1
Smed ID	SMED30000477
Length (bp)	1338

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein lifeguard 1 (SMED30000477) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein lifeguard 1 (SMED30000477) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30000477

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
prepharyngeal region	SMED30000477	h1SMcG0019735	SmedASXL_012392	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
gut	SMED30000477	h1SMcG0019735	dd_Smed_v4_16271_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of Protein lifeguard 1 vs. Ensembl Human
Match: GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:HGNC Symbol;Acc:HGNC:4589])

HSP 1 Score: 165.236 bits (417), Expect = 4.033e-46
Identity = 127/329 (38.60%), Postives = 179/329 (54.41%), Query Frame = 2

Query:  329 PQYPGHPSYGAQPQYPGRPT---YSGQPQYSPTDGGY--------SIPQ-PRPQV-YPYGSQLQNP-PIYSYGNPGNASLTNPDS---------------DTAHFVFTS---KSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            PQ P  PS   QP YP  P+     G PQ     GGY          PQ P PQ  YP G   Q+P P   YG P      +PDS               D   F  T+   KSIR AFIRKV+ +L+LQ+ +T+  +++  FV  +K +V+ N + Y V+ A+  + ++VL C    RRK P N++ L   T + S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 370

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Query:  329 PQYPGHPSYGAQPQYPGRPT---YSGQPQYSPTDGGY--------SIPQ-PRPQV-YPYGSQLQNP-PIYSYGNPGNASLTNPDS---------------DTAHFVFTS---KSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            PQ P  PS   QP YP  P+     G PQ     GGY          PQ P PQ  YP G   Q+P P   YG P      +PDS               D   F  T+   KSIR AFIRKV+ +L+LQ+ +T+  +++  FV  +K +V+ N + Y V+ A+  + ++VL C    RRK P N++ L   T + S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 370

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BLAST of Protein lifeguard 1 vs. Ensembl Human
Match: TMBIM1 (transmembrane BAX inhibitor motif containing 1 [Source:HGNC Symbol;Acc:HGNC:23410])

HSP 1 Score: 157.918 bits (398), Expect = 4.228e-44
Identity = 114/295 (38.64%), Postives = 167/295 (56.61%), Query Frame = 2

Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHF---VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YPG P    QP Y             P  YP      +P   +YG PG+       + +  F    +  + +R  FIRKVY+I+S+Q++IT+ ++A+  FVEP+  +V+RN  +Y V+ A+ +V  ++L C  GPRR+FP NIILL  FT A  FM G IS    T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV L  GI   I+        ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DI+ IF  VL +  + +
Sbjct:   34 GGYPAYPGYP----QPGYG-----------HPAGYPQPMPPTHPMPMNYG-PGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHF---VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YPG P    QP Y             P  YP      +P   +YG PG+       + +  F    +  + +R  FIRKVY+I+S+Q++IT+ ++A+  FVEP+  +V+RN  +Y V+ A+ +V  ++L C  GPRR+FP NIILL  FT A  FM G IS    T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV L  GI   I+        ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DI+ IF  VL +  + +
Sbjct:   34 GGYPAYPGYP----QPGYG-----------HPAGYPQPMPPTHPMPMNYG-PGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHF---VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YPG P    QP Y             P  YP      +P   +YG PG+       + +  F    +  + +R  FIRKVY+I+S+Q++IT+ ++A+  FVEP+  +V+RN  +Y V+ A+ +V  ++L C  GPRR+FP NIILL  FT A  FM G IS    T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV L  GI   I+        ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DI+ IF  VL +  + +
Sbjct:   34 GGYPAYPGYP----QPGYG-----------HPAGYPQPMPPTHPMPMNYG-PGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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BLAST of Protein lifeguard 1 vs. Ensembl Celegans
Match: xbx-6 (X-BoX promoter element regulated [Source:UniProtKB/TrEMBL;Acc:Q8MQ56])

HSP 1 Score: 132.494 bits (332), Expect = 3.734e-35
Identity = 97/280 (34.64%), Postives = 151/280 (53.93%), Query Frame = 2

Query:  392 SGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALI----MRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +G  Q     G Y  P P P      +Q++N      G  G     NPD   + F F+ K++R AF+RKV++++ + + I   +  +    +     V+RN  LY+ +  I  V  + L C  G RRKFP+N+I+   FTLA S M  VIS   D   V  A  I +    +I I A QTK D T   G +LI+S+ F+ FG+  +I     + + + ++Y   G LI  ++L +D Q+++GG   Y ISPE+YIFA++ +++DIVQ+F  +L +F +SD
Sbjct:   28 TGDGQNQNQGGAYFSPPP-PMHGAMFNQMEN------GQHGGGD--NPDGKYS-FQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKIKFLMMVYALGGALIMMLYLFLDVQMLMGGK-KYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSSD 296

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Query:  392 SGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALI----MRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +G  Q     G Y  P P P      +Q++N      G  G     NPD   + F F+ K++R AF+RKV++++ + + I   +  +    +     V+RN  LY+ +  I  V  + L C  G RRKFP+N+I+   FTLA S M  VIS   D   V  A  I +    +I I A QTK D T   G +LI+S+ F+ FG+  +I     + + + ++Y   G LI  ++L +D Q+++GG   Y ISPE+YIFA++ +++DIVQ+F  +L +F +SD
Sbjct:   28 TGDGQNQNQGGAYFSPPP-PMHGAMFNQMEN------GQHGGGD--NPDGKYS-FQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKIKFLMMVYALGGALIMMLYLFLDVQMLMGGK-KYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSSD 296

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Query:  392 SGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALI----MRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +G  Q     G Y  P P P      +Q++N      G  G     NPD   + F F+ K++R AF+RKV++++ + + I   +  +    +     V+RN  LY+ +  I  V  + L C  G RRKFP+N+I+   FTLA S M  VIS   D   V  A  I +    +I I A QTK D T   G +LI+S+ F+ FG+  +I     + + + ++Y   G LI  ++L +D Q+++GG   Y ISPE+YIFA++ +++DIVQ+F  +L +F +SD
Sbjct:   28 TGDGQNQNQGGAYFSPPP-PMHGAMFNQMEN------GQHGGGD--NPDGKYS-FQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKIKFLMMVYALGGALIMMLYLFLDVQMLMGGK-KYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSSD 296

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BLAST of Protein lifeguard 1 vs. Ensembl Celegans
Match: xbx-6 (X-BoX promoter element regulated [Source:UniProtKB/TrEMBL;Acc:Q8MQ56])

HSP 1 Score: 129.028 bits (323), Expect = 7.602e-34
Identity = 95/280 (33.93%), Postives = 150/280 (53.57%), Query Frame = 2

Query:  392 SGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALI----MRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +G  Q     G Y  P P P      +Q++N      G  G     NPD   + F F+ K++R AF+RKV++++ + + I   +  +    +     V+RN  LY+ +  I  V  + L C  G RRKFP+N+I+   FTLA S M  VIS   D   V  A  I +    +I I A QTK D T   G +LI+S+ F+ FG+  +I     + + + ++Y   G LI  ++L +D Q+++GG   Y ISPE+YIFA++ +++DIVQ+F  +L +F + +
Sbjct:   28 TGDGQNQNQGGAYFSPPP-PMHGAMFNQMEN------GQHGGGD--NPDGKYS-FQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKIKFLMMVYALGGALIMMLYLFLDVQMLMGGK-KYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSRN 296

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Query:  392 SGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALI----MRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +G  Q     G Y  P P P      +Q++N      G  G     NPD   + F F+ K++R AF+RKV++++ + + I   +  +    +     V+RN  LY+ +  I  V  + L C  G RRKFP+N+I+   FTLA S M  VIS   D   V  A  I +    +I I A QTK D T   G +LI+S+ F+ FG+  +I     + + + ++Y   G LI  ++L +D Q+++GG   Y ISPE+YIFA++ +++DIVQ+F  +L +F + +
Sbjct:   28 TGDGQNQNQGGAYFSPPP-PMHGAMFNQMEN------GQHGGGD--NPDGKYS-FQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKIKFLMMVYALGGALIMMLYLFLDVQMLMGGK-KYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSRN 296

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BLAST of Protein lifeguard 1 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0089877)

HSP 1 Score: 181.03 bits (458), Expect = 4.961e-53
Identity = 111/247 (44.94%), Postives = 162/247 (65.59%), Query Frame = 2

Query:  476 LQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            +Q PP  S G  G  +  +P+S   +F F  +SIR  FIRKVY IL  Q+++T G +AL ++ E  K + + N +L+ VA+ +++V M+ + C    RR+ P N I L  FT A+SF++GV +     + V  A  IT A+ +A+TIFA QTK DFT + G L+   +VFL FGI A+ ++ +++ L+Y  IG L+FS++L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IF+ +L I   S
Sbjct:   80 IQPPP--SAG--GYGAYDDPESQPKNFSFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIGAS 322

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BLAST of Protein lifeguard 1 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0089873)

HSP 1 Score: 181.03 bits (458), Expect = 4.961e-53
Identity = 111/247 (44.94%), Postives = 162/247 (65.59%), Query Frame = 2

Query:  476 LQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            +Q PP  S G  G  +  +P+S   +F F  +SIR  FIRKVY IL  Q+++T G +AL ++ E  K + + N +L+ VA+ +++V M+ + C    RR+ P N I L  FT A+SF++GV +     + V  A  IT A+ +A+TIFA QTK DFT + G L+   +VFL FGI A+ ++ +++ L+Y  IG L+FS++L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IF+ +L I   S
Sbjct:   80 IQPPP--SAG--GYGAYDDPESQPKNFSFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIGAS 322

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BLAST of Protein lifeguard 1 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0089875)

HSP 1 Score: 181.03 bits (458), Expect = 4.961e-53
Identity = 111/247 (44.94%), Postives = 162/247 (65.59%), Query Frame = 2

Query:  476 LQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            +Q PP  S G  G  +  +P+S   +F F  +SIR  FIRKVY IL  Q+++T G +AL ++ E  K + + N +L+ VA+ +++V M+ + C    RR+ P N I L  FT A+SF++GV +     + V  A  IT A+ +A+TIFA QTK DFT + G L+   +VFL FGI A+ ++ +++ L+Y  IG L+FS++L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IF+ +L I   S
Sbjct:   80 IQPPP--SAG--GYGAYDDPESQPKNFSFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIGAS 322

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BLAST of Protein lifeguard 1 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0089876)

HSP 1 Score: 180.259 bits (456), Expect = 9.153e-53
Identity = 111/247 (44.94%), Postives = 162/247 (65.59%), Query Frame = 2

Query:  476 LQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            +Q PP  S G  G  +  +P+S   +F F  +SIR  FIRKVY IL  Q+++T G +AL ++ E  K + + N +L+ VA+ +++V M+ + C    RR+ P N I L  FT A+SF++GV +     + V  A  IT A+ +A+TIFA QTK DFT + G L+   +VFL FGI A+ ++ +++ L+Y  IG L+FS++L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IF+ +L I   S
Sbjct:   69 IQPPP--SAG--GYGAYDDPESQPKNFSFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIGAS 311

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BLAST of Protein lifeguard 1 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0309295)

HSP 1 Score: 180.259 bits (456), Expect = 9.153e-53
Identity = 111/247 (44.94%), Postives = 162/247 (65.59%), Query Frame = 2

Query:  476 LQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            +Q PP  S G  G  +  +P+S   +F F  +SIR  FIRKVY IL  Q+++T G +AL ++ E  K + + N +L+ VA+ +++V M+ + C    RR+ P N I L  FT A+SF++GV +     + V  A  IT A+ +A+TIFA QTK DFT + G L+   +VFL FGI A+ ++ +++ L+Y  IG L+FS++L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IF+ +L I   S
Sbjct:   69 IQPPP--SAG--GYGAYDDPESQPKNFSFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIGAS 311

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BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Match: grinab (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-040426-1367])

HSP 1 Score: 172.94 bits (437), Expect = 1.113e-49
Identity = 117/280 (41.79%), Postives = 163/280 (58.21%), Query Frame = 2

Query:  395 GQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPP---IYSYGNPGNASLTNPDSDTAHFV---FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            G P Y     GY   QP P   PY +   + P   + + G PG +    P+ D+  F      +K IR  FIRKV+++LSLQ+ IT   +A+  F   +KL+V +N + Y V   + +V   V+ C    RRK P N+I L   TLA S+M+GVIS   DT  V  A  IT+ +   + IF+ QTK DFT   G L +  IV   FGI  +I  +++++LIY  +G L+F+ FL VDTQL+L GN + S+SPE+YIFA+LNLY+DI+QIFL +L I   S
Sbjct:   59 GSPAYGQGVSGYP-QQPYPVAAPYSTDPYSQPFPNVVAMGEPGQSD-DPPEYDSDQFSSSGLDNKEIRRVFIRKVFSVLSLQLAITTAFVAIFTFEPHVKLFVMQNSWTYWVGYLVFLVPYFVILCCGEFRRKHPWNLICLSVLTLAMSYMVGVISSFYDTDIVIMAIGITVVVCFTVIIFSMQTKYDFTSCYGVLFVCGIVLFVFGILCIIFYSKIMDLIYSTLGALLFTCFLAVDTQLLL-GNKNLSLSPEEYIFASLNLYLDIIQIFLFILRILGRS 335

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BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Match: grinab (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-040426-1367])

HSP 1 Score: 171.785 bits (434), Expect = 3.721e-49
Identity = 116/278 (41.73%), Postives = 163/278 (58.63%), Query Frame = 2

Query:  401 PQYSPTDGGYSIPQPRPQVYPYGSQLQNPP---IYSYGNPGNASLTNPDSDTAHFV---FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            P Y     GY   QP P   PY +   + P   + + G PG ++   P+ D+  F      +K IR  FIRKV+++LSLQ+ IT   +A+  F   +KL+V +N + Y V   + +V   V+ C    RRK P N+I L   TLA S+M+GVIS   DT  V  A  IT+ +   + IF+ QTK DFT   G L +  IV   FGI  +I  +++++LIY  +G L+F+ FL VDTQL+L GN + S+SPE+YIFA+LNLY+DI+QIFL +L I   S
Sbjct:   61 PAYGQGVSGYP-QQPYPVAAPYSTDPYSQPFPNVVAMGEPGQSN-DPPEYDSDQFTSSGLDNKEIRRVFIRKVFSVLSLQLAITTAFVAIFTFEPHVKLFVMQNSWTYWVGYLVFLVPYFVILCCGEFRRKHPWNLICLSVLTLAMSYMVGVISSFYDTDIVIMAIGITVVVCFTVIIFSMQTKYDFTSCYGVLFVCGIVLFVFGILCIIFYSKIMDLIYSTLGALLFTCFLAVDTQLLL-GNKNLSLSPEEYIFASLNLYLDIIQIFLFILRILGRS 335

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BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Match: zgc:110410 (zgc:110410 [Source:ZFIN;Acc:ZDB-GENE-050522-465])

HSP 1 Score: 170.244 bits (430), Expect = 7.216e-48
Identity = 116/310 (37.42%), Postives = 171/310 (55.16%), Query Frame = 2

Query:  329 PQYPGHPSYGAQ-PQYPGR-PTYSGQPQY-SPTDGGYSIPQPRPQVYPYGSQ--LQNPPIYSYGNPG-------NASLTNPDSDTAHF--------VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVL 1198
            PQYP      A  PQYP      +G PQY + T G    PQ     YP  +Q    +PP+      G       N ++ NPD     +         F+  +IR  FIRKVY  L +Q++IT+G++   L+ E +  WV+   +     + +   L++VL C    RRK PLN I L  FT+AE  +LG + +      V +A   T  + +A+++F+ Q+K DFT  SG +  +S    +F +   I+R++ + + Y  +G LIFS++L++DTQL+LGG H YSISPE+YIFAALNLY+DIV IFL++L
Sbjct:   94 PQYPNATQGNAGYPQYPNAIQGNAGYPQYPNATQGNAGYPQ-----YPNATQGNAGHPPMGMMPLAGMMPPTAENVNMGNPDDAPPEYTLGFENENCFSDAAIRRGFIRKVYLTLMIQLLITVGIICAFLYWETLSDWVKDTYWFTYTMMGVTFALVIVLVCCVDIRRKVPLNFIFLGLFTIAEGCLLGSVVVYYSAEAVLWAVGATALVSLAMSLFSLQSKWDFTAASGCIWAMSWTLFSFALLCAILRSQYLYIFYASLGTLIFSVYLVIDTQLILGGKHKYSISPEEYIFAALNLYIDIVTIFLLLL 398

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BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Match: grinaa (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-060616-231])

HSP 1 Score: 164.466 bits (415), Expect = 3.662e-46
Identity = 123/326 (37.73%), Postives = 182/326 (55.83%), Query Frame = 2

Query:  332 QYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSI-----------PQ-PRPQV------YPYGSQLQNPPIYSYGNPGNASLTNP-------------DSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            Q PG P Y A   Y G P Y GQP Y                    PQ P PQ       YP     Q P   ++G   NAS+ +P             + D A+  +  KSIR AFIRKV+ +L++Q+++T   + +  F + +K++V+RN++ Y V+ AI  V ++VL C    RRK P N++ L   TL+ S+++G+I+   DT  V  A  IT+ +  A+ +F+ QTK DFT   G LL+ +IV L   I  + +RN++++++Y  +G L+F+ FL VDTQL+L GN   +ISPE+Y+FAALNLY DI+ IFL +L I   +
Sbjct:   39 QGPGAPPYAAPGPY-GPPDY-GQPAYGQPPAPGFGPGPGPYPQMPYPQMPYPQANYAQGPYPQSPYQQGPGQPAFGVDPNASMESPGYHGGDGPPSYYGNDDFANSNWEDKSIRRAFIRKVFMVLTVQLLVTFSFVTVFTFAKDVKVFVRRNQWTYYVSYAIFFVSLIVLSCCGEVRRKHPWNLVALSILTLSLSYLVGMIASFYDTDAVIMAVGITVVVCFAVVVFSLQTKYDFTSCYGVLLVCTIVLLVACILCIFIRNKILHIVYASLGALLFTCFLAVDTQLLL-GNKKLAISPEEYVFAALNLYTDIINIFLYILAIVGRT 361

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BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1a [Source:ZFIN;Acc:ZDB-GENE-041010-69])

HSP 1 Score: 162.54 bits (410), Expect = 1.005e-45
Identity = 127/304 (41.78%), Postives = 180/304 (59.21%), Query Frame = 2

Query:  335 YPGHPSYGAQPQYP--GRPT--YSGQPQYSPTDGGYSIP-QPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIF-ALIMRNRLV---NLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            Y G P Y  QP  P  G+P   Y GQP   P  G  + P + +P  YP  +    P +   G   +   T  +       F S  +R +FIRKVY IL+ Q+++T  ++A+  FVEP+ L+V++N  +Y V+ AI  V  +VL C  GPRR+FP N++LL  FTLA SFM G I+    TR V  A  IT+ + VA+T+F FQTK+DFT  SG   +L IV    GI  A+++  + V   +++Y  IG + F++FL   TQL++G N   SISPE+Y+FAAL+LYVDIVQIF+ +L I   ++
Sbjct:   37 YEGQPGY-PQPNDPYRGQPNDPYRGQPN-DPYRGQPNDPYRGQPAGYPPPAMPVIPVMPPPGIGDSEGFTTAEG------FESTDVRHSFIRKVYLILAAQLLVTAAVVAIFTFVEPVGLFVRKNPAIYWVSYAIYFVTHIVLVCCQGPRRRFPWNLLLLAIFTLALSFMTGNIASYYSTRAVFLALAITVVVCVAVTVFCFQTKVDFTKCSGFFCVLGIVVFVTGIITAIVLSFKYVPWLHMLYASIGAIAFTLFLAYHTQLLIG-NRKLSISPEEYVFAALSLYVDIVQIFIFLLQIIGYAE 331

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BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
Match: grina (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:NCBI gene;Acc:100145094])

HSP 1 Score: 177.948 bits (450), Expect = 9.721e-52
Identity = 123/304 (40.46%), Postives = 172/304 (56.58%), Query Frame = 2

Query:  326 TPQYPGHPSYGAQPQ----YPGRPTYSGQPQYSPTDGGYSIPQPRPQV------YPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIF 1207
             P YP  P+ G  P      P  P+YS Q    P      I  P  Q+      YP       PP Y++G  G++             F+  +IR AFIRKVY  L++Q+ +T+GL+ + +F + +K WVQ   Y+       +I+L +VL C    RRK P N I L  FT  E  MLG I+   D   V +A   T+ + + +TIFA QTK DFT LSGGL +  +V L FGI   I+R+  +N++Y  IG  IF ++L+VDTQL++GG H Y++SPE+YIFAALN+Y+DI+ +FLM+L IF
Sbjct:   20 NPLYP--PAMGGGPSVPVYMPPPPSYSEQ---DPAALNAQINNPSSQIFLEANSYPEHDAEAGPPEYTFGVVGSSP------------FSESAIRRAFIRKVYLTLAMQLALTVGLICMFIFWKRLKNWVQEYPYIVYALCPAIIILALVLACCQQVRRKVPYNFIFLGLFTAVEGCMLGTIAALFDADAVMWAGGATIVVTLGLTIFALQTKWDFTMLSGGLCVALLVLLCFGILCGILRSMYLNIVYASIGTFIFGMYLVVDTQLIVGGKHRYAVSPEEYIFAALNIYLDIINLFLMLLQIF 306

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Query:  326 TPQYPGHPSYGAQPQ----YPGRPTYSGQPQYSPTDGGYSIPQPRPQV------YPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIF 1207
             P YP  P+ G  P      P  P+YS Q    P      I  P  Q+      YP       PP Y++G  G++             F+  +IR AFIRKVY  L++Q+ +T+GL+ + +F + +K WVQ   Y+       +I+L +VL C    RRK P N I L  FT  E  MLG I+   D   V +A   T+ + + +TIFA QTK DFT LSGGL +  +V L FGI   I+R+  +N++Y  IG  IF ++L+VDTQL++GG H Y++SPE+YIFAALN+Y+DI+ +FLM+L IF
Sbjct:   20 NPLYP--PAMGGGPSVPVYMPPPPSYSEQ---DPAALNAQINNPSSQIFLEANSYPEHDAEAGPPEYTFGVVGSSP------------FSESAIRRAFIRKVYLTLAMQLALTVGLICMFIFWKRLKNWVQEYPYIVYALCPAIIILALVLACCQQVRRKVPYNFIFLGLFTAVEGCMLGTIAALFDADAVMWAGGATIVVTLGLTIFALQTKWDFTMLSGGLCVALLVLLCFGILCGILRSMYLNIVYASIGTFIFGMYLVVDTQLIVGGKHRYAVSPEEYIFAALNIYLDIINLFLMLLQIF 306

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BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
Match: tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:595060])

HSP 1 Score: 162.54 bits (410), Expect = 1.829e-45
Identity = 113/297 (38.05%), Postives = 177/297 (59.60%), Query Frame = 2

Query:  341 GHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNP-DSDTAHF-VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIF-ALIMRNRLV---NLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSN 1213
            G P+ G  PQ  G P  SG PQ     GGY  P       P    L   P+    N G+  + N  D +  +F  +  K++R AFIR+VYAI+++Q+++T+G++A+  +VEP+  +++R   +Y  + A+  V  +VL C  GPRR+FP NIILL  FTLA +FM G I+    ++ V  +  IT  + + +TIF FQTK+DFT  +G   +L IV    GI  A+++  + V   +++Y  +G ++F++FL  DTQL++ GN  ++I+PE+Y++ AL +Y DIV IFL +L I  +
Sbjct:   65 GQPA-GYYPQPGGYPAPSGYPQ----PGGYPEPGHNDPPKPVMPILPTIPL----NTGDGEMYNTNDGEGGNFGSWDDKAVRHAFIRRVYAIIAVQLLLTVGIIAIFTYVEPVTSFIRRTPGVYYASYAVFFVTYIVLVCCEGPRRRFPWNIILLAIFTLAMAFMAGTIASFYSSKAVLISMGITAIVTIIVTIFCFQTKVDFTSCAGLFAVLGIVMFVTGIVTAIVLAFKYVYWLHMLYAALGAIVFTLFLAFDTQLVI-GNRKHTINPEEYVYGALKIYTDIVYIFLNLLQIIGS 351

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BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
Match: faim2 (Fas apoptotic inhibitory molecule 2 [Source:NCBI gene;Acc:779810])

HSP 1 Score: 158.688 bits (400), Expect = 2.347e-44
Identity = 110/295 (37.29%), Postives = 171/295 (57.97%), Query Frame = 2

Query:  347 PSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIM----RNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            PSY       G+     Q   SPT   +S     P    Y S   +  IYS    G+  +    S      + ++++R  FIRKVYAIL +Q+++T+ ++AL  F +P+K ++Q N   Y  + A+     +VL C +GPRRKFP N+ILL  FTL+ +++ G++S   +T+ V     IT  + +++T+F+FQ+KIDFT   G L +LS+V L  GIF +I+        ++ +Y  IG ++F++FL  DTQ ML G+  YS+SPE+YIF ALN+Y+DI+ IF  +L +F   +
Sbjct:   33 PSYEEATAGDGKKADYLQAT-SPTLSQHSWQHGEP----YNSPDCSSGIYS----GDTEMLTTQS------WDNETVRRGFIRKVYAILMIQLLVTVAVVALFTFCDPVKGYIQANPGWYWASYAVFFSTYLVLACCSGPRRKFPWNLILLCIFTLSMAYITGMLSSFYNTKSVILCLGITALVCMSVTLFSFQSKIDFTSCQGVLFVLSMVLLFSGIFLVILIPFQYIPWLHAVYAVIGAIVFTMFLAFDTQ-MLMGSRRYSLSPEEYIFGALNIYLDIIYIFSFLLQLFGTQE 311

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BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
Match: grina (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:NCBI gene;Acc:100145094])

HSP 1 Score: 147.517 bits (371), Expect = 9.437e-41
Identity = 108/284 (38.03%), Postives = 152/284 (53.52%), Query Frame = 2

Query:  374 PGRPTYSGQPQYSPTDGGYSIPQPRPQV------YPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIF 1207
            P  P+YS Q    P      I  P  Q+      YP       PP Y++G  G++             F+  +IR AFIRKVY  L++Q+ +T+GL+ + +F + +K WVQ   Y+                     RRK P N I L  FT  E  MLG I+   D   V +A   T+ + + +TIFA QTK DFT LSGGL +  +V L FGI   I+R+ +V++ Y          +L+VDTQL++GG H Y++SPE+YIFAALN+Y+DI+ +FLM+L IF
Sbjct:   12 PPPPSYSEQ---DPAALNAQINNPSSQIFLEANSYPEHDAEAGPPEYTFGVVGSSP------------FSESAIRRAFIRKVYLTLAMQLALTVGLICMFIFWKRLKNWVQEYPYIVYQV-----------------RRKVPYNFIFLGLFTAVEGCMLGTIAALFDADAVMWAGGATIVVTLGLTIFALQTKWDFTMLSGGLCVALLVLLCFGILCGILRS-MVSIQYVS--------YLVVDTQLIVGGKHRYAVSPEEYIFAALNIYLDIINLFLMLLQIF 254

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BLAST of Protein lifeguard 1 vs. Ensembl Mouse
Match: Tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:MGI Symbol;Acc:MGI:1916910])

HSP 1 Score: 154.451 bits (389), Expect = 5.441e-43
Identity = 111/292 (38.01%), Postives = 163/292 (55.82%), Query Frame = 2

Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGI---FALIMRN-RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YP  P    QP Y             P  YP      +P   +YG+  N              +  + +R +FI+KVY I+S+Q++IT+ ++A+  FVEP+  +V+ N  +Y V+ A+ +V  + L C  GPRR+FP NIILL  FTLA  F+ G IS   +T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV +  GI     LI +    ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DIV IF  VL +  + D
Sbjct:   34 GGYPAYPAYP----QPGYG-----------HPAGYPQPVPPVHPMPMNYGHDYNEEERAGSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

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Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGI---FALIMRN-RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YP  P    QP Y             P  YP      +P   +YG+  N              +  + +R +FI+KVY I+S+Q++IT+ ++A+  FVEP+  +V+ N  +Y V+ A+ +V  + L C  GPRR+FP NIILL  FTLA  F+ G IS   +T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV +  GI     LI +    ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DIV IF  VL +  + D
Sbjct:   34 GGYPAYPAYP----QPGYG-----------HPAGYPQPVPPVHPMPMNYGHDYNEEERAGSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

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BLAST of Protein lifeguard 1 vs. Ensembl Mouse
Match: Grina (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:MGI Symbol;Acc:MGI:1913418])

HSP 1 Score: 154.066 bits (388), Expect = 1.871e-42
Identity = 129/318 (40.57%), Postives = 181/318 (56.92%), Query Frame = 2

Query:  335 YPGHPSYGAQPQYPGRPTYSGQPQY----SP-TDGGYSIPQ-PRPQV-YPYGSQLQNP----------PIYSYGNP--GNASLTNPDS--DTAHF--VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            YPG P     PQ P +P+  GQP Y    SP   GGY  PQ P PQ  YP G   Q+P          P    G+P  GN     P S  D   F  V   K+IR AFIRKV+ +L+LQ+ +T+  +A+  FV  +K +V+ N + Y V+ AI  + ++VL C    RRK P N++ L   T++ S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   34 YPGAP----YPQAPFQPSPYGQPGYPHGPSPYPQGGY--PQGPYPQGGYPQGPYPQSPFPPNPYGQPPPFQDPGSPQHGNYQEEGPPSYYDNQDFPAVNWDKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 344

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BLAST of Protein lifeguard 1 vs. Ensembl Mouse
Match: Tmbim7 (transmembrane BAX inhibitor motif containing 7 [Source:MGI Symbol;Acc:MGI:1922305])

HSP 1 Score: 144.05 bits (362), Expect = 3.406e-39
Identity = 94/259 (36.29%), Postives = 152/259 (58.69%), Query Frame = 2

Query:  428 YSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGI 1204
            YS P+ R     Y  Q+          P N ++           F + SIR  FI KV+ +LS+Q+ IT  ++ + +F EP++ WV    +     +  V++L+ VL C    RR+ P N ILL  FT+ E  +LG +S+      + +A   T  + + +T+FA QTK DFT L+G + + + V L +GI AL++R+  ++L+Y  +G L+FSI+L++D Q+M+GG + Y I+PE+YIFAALN+YVDI+ +F+ +L +
Sbjct:   52 YSHPRNRDGANTYAVQVSEDV-----TPSNETVNQS------IPFENTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPANYILLAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQMMVGGRYHYEINPEEYIFAALNIYVDIISLFIFILDL 299

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BLAST of Protein lifeguard 1 vs. Ensembl Mouse
Match: Faim2 (Fas apoptotic inhibitory molecule 2 [Source:MGI Symbol;Acc:MGI:1919643])

HSP 1 Score: 144.821 bits (364), Expect = 3.418e-39
Identity = 103/302 (34.11%), Postives = 167/302 (55.30%), Query Frame = 2

Query:  344 HPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYG-SQLQNPPIYSYGNPGNASLTN---PDSDTAHFV---FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFG-IFALIMRNRLV---NLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            H + G +   P  P  S  P Y     G  +   +   +P G + +   P ++Y +P  +S      P     HF    +  + +R  FIRKVY IL +Q+++T+ ++AL  F + +K +VQ N   Y  + A+     + L C +GPRR FP N+ILL  FTL+ +++ G++S   +T  V    VIT  + +++TIF+FQTK DFT   G L +L +     G + A+++  + V   + +Y  +G  +F++FL  DTQL++ GN  +S+SPE+YIF ALN+Y+DI+ IF   L +F  +
Sbjct:   20 HQANGEKKDAPAVP--SAPPSYEEATSGEGL---KAGTFPQGPTAVPLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVLFVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLM-GNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTN 315

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BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Match: sp|Q7Z429|LFG1_HUMAN (Protein lifeguard 1 OS=Homo sapiens OX=9606 GN=GRINA PE=1 SV=1)

HSP 1 Score: 165.236 bits (417), Expect = 1.937e-45
Identity = 127/329 (38.60%), Postives = 179/329 (54.41%), Query Frame = 2

Query:  329 PQYPGHPSYGAQPQYPGRPT---YSGQPQYSPTDGGY--------SIPQ-PRPQV-YPYGSQLQNP-PIYSYGNPGNASLTNPDS---------------DTAHFVFTS---KSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            PQ P  PS   QP YP  P+     G PQ     GGY          PQ P PQ  YP G   Q+P P   YG P      +PDS               D   F  T+   KSIR AFIRKV+ +L+LQ+ +T+  +++  FV  +K +V+ N + Y V+ A+  + ++VL C    RRK P N++ L   T + S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 370

[Close]

BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Match: sp|Q969X1|LFG3_HUMAN (Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMBIM1 PE=1 SV=2)

HSP 1 Score: 157.918 bits (398), Expect = 2.030e-43
Identity = 114/295 (38.64%), Postives = 167/295 (56.61%), Query Frame = 2

Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHF---VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YPG P    QP Y             P  YP      +P   +YG PG+       + +  F    +  + +R  FIRKVY+I+S+Q++IT+ ++A+  FVEP+  +V+RN  +Y V+ A+ +V  ++L C  GPRR+FP NIILL  FT A  FM G IS    T+ V  A +IT  + +++TIF FQTK+DFT  +G   +L IV L  GI   I+        ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DI+ IF  VL +  + +
Sbjct:   34 GGYPAYPGYP----QPGYG-----------HPAGYPQPMPPTHPMPMNYG-PGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

[Close]

BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Match: sp|Q9ESF4|LFG1_MOUSE (Protein lifeguard 1 OS=Mus musculus OX=10090 GN=Grina PE=2 SV=1)

HSP 1 Score: 154.066 bits (388), Expect = 1.309e-41
Identity = 129/318 (40.57%), Postives = 181/318 (56.92%), Query Frame = 2

Query:  335 YPGHPSYGAQPQYPGRPTYSGQPQY----SP-TDGGYSIPQ-PRPQV-YPYGSQLQNP----------PIYSYGNP--GNASLTNPDS--DTAHF--VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            YPG P     PQ P +P+  GQP Y    SP   GGY  PQ P PQ  YP G   Q+P          P    G+P  GN     P S  D   F  V   K+IR AFIRKV+ +L+LQ+ +T+  +A+  FV  +K +V+ N + Y V+ AI  + ++VL C    RRK P N++ L   T++ S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   34 YPGAP----YPQAPFQPSPYGQPGYPHGPSPYPQGGY--PQGPYPQGGYPQGPYPQSPFPPNPYGQPPPFQDPGSPQHGNYQEEGPPSYYDNQDFPAVNWDKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 344

[Close]

BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Match: sp|Q6P6R0|LFG1_RAT (Protein lifeguard 1 OS=Rattus norvegicus OX=10116 GN=Grina PE=2 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 2.923e-41
Identity = 128/317 (40.38%), Postives = 179/317 (56.47%), Query Frame = 2

Query:  329 PQYPG--HPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQ-PRPQV-YPYGSQLQNP----------PIYSYGNP--GNASLTNPDS--DTAHF--VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            P YPG  +P    QP   G+P Y   P   P  GGY  PQ P PQ  YP G   Q+P          P    G+P  GN     P S  D   F  V   KSIR AFIRKV+ +L+LQ+ +T+  +A+  FV  +K +V+ N + Y V+ AI  + ++VL C    RRK P N++ L   T++ S+M+G+I+   +T  V  A  IT A+   + IF+ QT+ DFT   G LL+  +V   F I  + +RNR++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY DI+ IFL +L I   + 
Sbjct:   35 PPYPGAPYPQAAFQPSPYGQPGYPHGPGPYP-QGGY--PQGPYPQGGYPQGPYPQSPFPPNPYGQPPPFQDPGSPQHGNYQEEGPPSYYDNQDFPSVNWDKSIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRANVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTISLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLL-GNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAK 347

[Close]

BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Match: sp|Q8BJZ3|LFG3_MOUSE (Protein lifeguard 3 OS=Mus musculus OX=10090 GN=Tmbim1 PE=1 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 8.009e-41
Identity = 109/292 (37.33%), Postives = 162/292 (55.48%), Query Frame = 2

Query:  356 GAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGI---FALIMRN-RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            G  P YP  P    QP Y             P  YP      +P   +YG+  N              +  + +R +FI+KVY I+S+Q++IT+ ++A+  FVEP+  +V+ N  +Y V+ A+ +V  + L C  GPRR+FP +IILL  FTLA  F+ G IS   + + V  A +IT  + +++TIF FQTK+DFT  +G   +L IV +  GI     LI +    ++++Y  +G + F++FL  DTQL+L GN  ++ISPEDYI  AL +Y DIV IF  VL +  + D
Sbjct:   34 GGYPAYPAYP----QPGYG-----------HPAGYPQPVPPVHPMPMNYGHDYNEEERAGSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWDIILLTIFTLALGFVTGTISSMYENKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

[Close]

BLAST of Protein lifeguard 1 vs. TrEMBL
Match: A0A267FI04 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig028790g2 PE=3 SV=1)

HSP 1 Score: 209.534 bits (532), Expect = 1.951e-61
Identity = 120/225 (53.33%), Postives = 163/225 (72.44%), Query Frame = 2

Query:  542 DTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            D  +  F  +SIR  F+RKVY IL++Q+V+T+G +AL +F +PIK +  RN +LYI+A+ + I+L++VL C    RRKFP+N+ILL  FTL ES+MLG IS   DT  V  A  +T+ IV A+T+FA QTKIDFTYLSG L +L I  + FG+   I++NR   L Y C+G L+FS++L+VDTQ+MLGG H YS+SPE+Y+FAALNLY+DIV IFL +L I   +
Sbjct:   19 DNGNMQFNEESIRKGFVRKVYGILTVQLVVTMGFIALFVFCQPIKQYAIRNDWLYILALVLTIILVIVLACCEDVRRKFPVNLILLGLFTLCESYMLGSISARFDTDAVFMAIGVTVFIVFALTLFAMQTKIDFTYLSGILFVLLIALILFGLLCAIVQNRFATLAYACLGALLFSVYLVVDTQMMLGGKHKYSLSPEEYVFAALNLYLDIVNIFLFILMIIQGA 243

[Close]

BLAST of Protein lifeguard 1 vs. TrEMBL
Match: A0A212FK47 (Uncharacterized protein OS=Danaus plexippus plexippus OX=278856 GN=KGM_210311 PE=3 SV=1)

HSP 1 Score: 204.527 bits (519), Expect = 1.406e-59
Identity = 122/239 (51.05%), Postives = 166/239 (69.46%), Query Frame = 2

Query:  500 YGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            Y  PG    +  D +  +F FT KSIR  FIRKVYAIL  Q+++T+G++A  LF EP K++V++N YL  +A+A++ + ++VL C T  RR+FPLN I L  FT AESF+LGV+    +   V  A  IT A+ + +T+FAFQTK DFT + G L+ LS+V L FGI A+I RN +++  Y   G LIFS++L+ DTQLM+GG H YSISPE+YIFAALNLYVDI+ IF+ +L + S S
Sbjct:    6 YVGPG----SFEDGNMDNFDFTEKSIRRGFIRKVYAILMSQLLVTMGIIAFFLFHEPTKVFVRQNFYLLWIAMAVLFIAIIVLACCTEMRRQFPLNFIFLAIFTCAESFILGVVCSLYEVNQVLMAVGITAAVCLGLTLFAFQTKWDFTMMGGALVALSMVLLVFGILAIIFRNNILHTAYAAAGALIFSLYLVYDTQLMMGGKHKYSISPEEYIFAALNLYVDIINIFIFILSLSSKS 240

[Close]

BLAST of Protein lifeguard 1 vs. TrEMBL
Match: H9JQS1 (Uncharacterized protein OS=Bombyx mori OX=7091 PE=3 SV=1)

HSP 1 Score: 204.527 bits (519), Expect = 1.353e-58
Identity = 127/270 (47.04%), Postives = 172/270 (63.70%), Query Frame = 2

Query:  419 DGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPG----NASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
             GGY+ PQP  Q   YG          YG PG    N S+   D +   F FT KSIR AFIRKVYAIL  Q+++T+G +AL L+  P K+WV +N +++ VA  ++IV ++ + C    RRK P N I L  FT A+SF+LG+ +   +   V  A  IT A+ + +T+FA QTK DFT + G LL  +IV L FGI A+ ++ +++ L+Y  +G LIFSI+L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IFL +L I   S
Sbjct:   54 QGGYAPPQPGFQP-AYGGA-------GYGEPGYIPPNDSV-GEDGEVKGFDFTEKSIRRAFIRKVYAILMCQLMVTMGFIALFLYHRPTKVWVAQNPFMFWVAFIVLIVCLIAMACCPDVRRKAPTNFIFLAIFTAAQSFLLGISASVYEADAVLMAVGITAAVCLGLTLFALQTKWDFTMMGGVLLCATIVLLVFGIVAIFVKGKVITLVYASLGALIFSIYLVYDTQLMMGGKHKYSISPEEYIFAALNLYLDIINIFLFILTIIGAS 314

[Close]

BLAST of Protein lifeguard 1 vs. TrEMBL
Match: Q2F693 (Glutamate receptor Gr1 OS=Bombyx mori OX=7091 PE=2 SV=1)

HSP 1 Score: 203.371 bits (516), Expect = 3.083e-58
Identity = 127/270 (47.04%), Postives = 171/270 (63.33%), Query Frame = 2

Query:  419 DGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPG----NASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
             GGY+ PQP  Q   YG          YG PG    N S+   D +   F FT KSIR AFIRKVYAIL  Q+++T+G +AL L+  P K+WV +N +++ VA  ++IV ++ + C    RRK P N I L  FT A+SF+LG+ +       V  A  IT A+ + +T+FA QTK DFT + G LL  +IV L FGI A+ ++ +++ L+Y  +G LIFSI+L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IFL +L I   S
Sbjct:   53 QGGYAPPQPGFQP-AYGGA-------GYGEPGYIPPNDSV-GEDGEVKGFDFTEKSIRRAFIRKVYAILMCQLMVTMGFIALFLYHRPTKVWVAQNPFMFWVAFIVLIVCLIAMACCPDVRRKAPTNFIFLAIFTAAQSFLLGISASVYQADAVLMAVGITAAVCLGLTLFALQTKWDFTMMGGVLLCATIVLLVFGIVAIFVKGKVITLVYASLGALIFSIYLVYDTQLMMGGKHKYSISPEEYIFAALNLYLDIINIFLFILTIIGAS 313

[Close]

BLAST of Protein lifeguard 1 vs. TrEMBL
Match: Q2F692 (Glutamate receptor Gr2 OS=Bombyx mori OX=7091 PE=2 SV=1)

HSP 1 Score: 203.371 bits (516), Expect = 3.659e-58
Identity = 127/270 (47.04%), Postives = 171/270 (63.33%), Query Frame = 2

Query:  419 DGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPG----NASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
             GGY+ PQP  Q   YG          YG PG    N S+   D +   F FT KSIR AFIRKVYAIL  Q+++T+G +AL L+  P K+WV +N +++ VA  ++IV ++ + C    RRK P N I L  FT A+SF+LG+ +       V  A  IT A+ + +T+FA QTK DFT + G LL  +IV L FGI A+ ++ +++ L+Y  +G LIFSI+L+ DTQLM+GG H YSISPE+YIFAALNLY+DI+ IFL +L I   S
Sbjct:   59 QGGYAPPQPGFQP-AYGGA-------GYGEPGYIPPNDSV-GEDGEVKGFDFTEKSIRRAFIRKVYAILMCQLMVTMGFIALFLYHRPTKVWVAQNPFMFWVAFIVLIVCLIAMACCPDVRRKAPTNFIFLAIFTAAQSFLLGISASVYQADAVLMAVGITAAVCLGLTLFALQTKWDFTMMGGVLLCATIVLLVFGIVAIFVKGKVITLVYASLGALIFSIYLVYDTQLMMGGKHKYSISPEEYIFAALNLYLDIINIFLFILTIIGAS 319

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Match: grinab (protein lifeguard 1-like [Source:NCBI gene;Acc:103028312])

HSP 1 Score: 169.088 bits (427), Expect = 3.597e-48
Identity = 119/313 (38.02%), Postives = 172/313 (54.95%), Query Frame = 2

Query:  329 PQYPGHPSYGAQPQYPG-----RPTYSGQPQYSPTDGGYSIPQ-PRPQVYPYGSQLQNPPIYSYGNPGNASLTNP----------DSDTAHFV-FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            P Y G P   A P  PG      P   GQP Y    G    PQ P P + PYG      P   Y    +  +++P          D D      F  K++R AFIRKV+ +L+ Q+V+T   +AL  F + IK +VQ+N + Y V+ A+ I+ ++ + C    RRK P N++ L   TL+ S+M G+I+   DT  V  A  IT+ +   + IF+ Q+K DFT   G L +  IV   FGI  + +RN++++++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+F ALNLY+DI+ IFL +L I   S
Sbjct:   35 PDYAGMP---AGPGAPGGLPFPTPGAFGQPMYG--QGAPGFPQAPFPHMAPYGQPQNQGPSQPYQYHPSEPMSDPYQSTDEPPAYDHDDIRISGFDDKAVRRAFIRKVFLVLTAQLVVTFSFVALFTFEKNIKTFVQQNVWTYYVSYAVFIIPLIAISCCGEFRRKHPWNLVALSILTLSMSYMTGMIASFYDTDTVVMAVGITVVVCFTVVIFSMQSKYDFTSCMGVLFVCVIVLFVFGILCIFIRNKILDIVYASLGALVFTCFLAVDTQLLL-GNKKLSLSPEEYVFGALNLYLDIINIFLYILQIVGRS 341

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BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Match: grinab (protein lifeguard 1-like [Source:NCBI gene;Acc:103028312])

HSP 1 Score: 164.081 bits (414), Expect = 7.099e-46
Identity = 116/316 (36.71%), Postives = 170/316 (53.80%), Query Frame = 2

Query:  326 TPQYPGHPSYG-AQPQYPGRPTYSGQPQYSPTDGGYSIP---QPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFV---------------FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            TP   G P YG   P +P  P     P   P + G S P    P  + +P    + +P   S G       T P SD                    F  K++R AFIRKV+ +L+ Q+V+T   +AL  F + IK +VQ+N + Y V+ A+ I+ ++ + C    RRK P N++ L   TL+ S+M G+I+   DT  V  A  IT+ +   + IF+ Q+K DFT   G L +  IV   FGI  + +RN++++++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+F ALNLY+DI+ IFL +L I   S
Sbjct:   66 TPGAFGQPMYGQGAPGFPQAPFPHMAPYGQPQNQGPSQPYQYHPSGEYHPLSIHISSPVSVSAGQ-RTECRTEPMSDPYQSTDEPPAYDHDDIRISGFDDKAVRRAFIRKVFLVLTAQLVVTFSFVALFTFEKNIKTFVQQNVWTYYVSYAVFIIPLIAISCCGEFRRKHPWNLVALSILTLSMSYMTGMIASFYDTDTVVMAVGITVVVCFTVVIFSMQSKYDFTSCMGVLFVCVIVLFVFGILCIFIRNKILDIVYASLGALVFTCFLAVDTQLLL-GNKKLSLSPEEYVFGALNLYLDIINIFLYILQIVGRS 379

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BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Match: zgc:110410 (protein lifeguard 1-like [Source:NCBI gene;Acc:111193442])

HSP 1 Score: 159.458 bits (402), Expect = 8.365e-45
Identity = 95/241 (39.42%), Postives = 146/241 (60.58%), Query Frame = 2

Query:  485 PPIYSYGNPGNASLTNPDSDTAHF---VFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVL 1198
            PP   + N        PD   A      F+   IR AF+RKVY  L +Q++IT+G++   ++ + ++ W +   +     +A  +VL+VVL C    RRK PLN I L  FT+ E  +LG +++      V +A   T  +  A+++FA Q+K DFT  SG +  +    ++FG+   I+R++ + ++Y  +G L+FSI+L++DTQL+LGG H YSISPE+YIFAALNLY+DI+ IFLM+L
Sbjct:   74 PPTDHHDNIEMQDSAPPDYTQAFEDMNCFSEAVIRRAFVRKVYLTLVVQLLITVGIICAFIYWDTLRKWARGTPWFTYAMMAATLVLIVVLSCCGDVRRKVPLNFIFLGLFTITEGLLLGSVTVFYSAEAVLWAVGATALVSFALSLFAMQSKWDFTAASGSIWAICWTLVSFGLLCAILRSQYLYIVYASLGTLVFSIYLVMDTQLILGGKHKYSISPEEYIFAALNLYLDIITIFLMIL 314

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BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:103036676])

HSP 1 Score: 159.458 bits (402), Expect = 1.994e-44
Identity = 97/224 (43.30%), Postives = 147/224 (65.62%), Query Frame = 2

Query:  560 FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            + S S+R  FIRKVY IL+ Q+++T+ ++A+  FV+P++ +V RN  +Y  + A+  +  ++L C  GPRR+FP N+ILL  FTLA S+M G IS   DT+ V  A  IT+ + +A+T+F FQTK+DFT   G   +L IV    GI   I+ +      ++++Y  IG + F++FL   TQL++G N  +SISPE+Y+FAAL++YVD++QIFL +L I   S 
Sbjct:  133 WESLSVRHTFIRKVYMILAAQLLLTVSIVAVFTFVQPVRTFVVRNPGVYWASYAVYFITHIMLVCCKGPRRRFPWNLILLGIFTLAMSYMAGTISSYYDTKSVFLALGITVIVCIAVTVFCFQTKVDFTKCGGLFCVLGIVVFVTGIITAIVLSFKYIPWLHMLYAAIGAIAFTLFLAYHTQLLIG-NRKHSISPEEYVFAALSIYVDVIQIFLFLLQIIGASQ 355

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BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Match: grinaa (glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:NCBI gene;Acc:103028129])

HSP 1 Score: 157.532 bits (397), Expect = 9.148e-44
Identity = 101/272 (37.13%), Postives = 161/272 (59.19%), Query Frame = 2

Query:  443 PRPQ-VYPYGSQLQNPPIYSYGNPGNASLTNP-------------DSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            P PQ  YP G   Q P    +G   NA L +P             + + A+  +  KSIR AFIRKV+ +L++Q+++T   +A+  F   +KL+V++N++ Y V+  +  V ++ L C    RRK P N++ L   TL+ S+M+G+I+   +T  V  A  IT  +  ++ IF+ Q+K DFT   G L +  IV + F    +++R+++++++Y  +G L+F+ FL VDTQL+L GN   ++SPE+YIFAALNLY DI+ IF+ +L I   S
Sbjct:   83 PYPQGPYPQGPYQQGPGQPGFGMDPNAPLGSPGYHGGDGPPSYYDNEEFANSGWEDKSIRQAFIRKVFMVLTVQLMVTFSFVAVFTFSNDVKLFVRQNRWTYYVSYVVFFVSLIALSCCGEFRRKHPWNLVALSILTLSLSYMVGMIASFYNTDSVIIAVGITSVVCFSVVIFSLQSKYDFTSCRGVLFVCLIVLILFSFLCMVIRHKILHIVYASLGALLFTCFLAVDTQLLL-GNKKLALSPEEYIFAALNLYTDIINIFMYILAIVGRS 353

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 157.532 bits (397), Expect = 5.633e-45
Identity = 104/256 (40.62%), Postives = 156/256 (60.94%), Query Frame = 2

Query:  488 PIYSYGNPGNASLTNPDSDTAHFV--------FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIM----RNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            P  SYG    +    P +DT+  +        +  K++R  FIRKVYAIL LQ+++T G++A+    EP+  +V+RN  LY  + A+ +V  +VL C   PRR+FPLNIILL  FTLA S+M G ++    TR V     IT  +  ++TIF FQTK DFT   G L +L +  +  G+ A I         ++++Y  +G ++F++FL  DTQL++ GN  Y+ISPE++IFA+LNLY+D+V IF+ +L IF + +
Sbjct:   52 PAPSYGQAYTSPSYTPYTDTSSNIGDSFSSNTWEDKNLRRVFIRKVYAILMLQLLVTFGIVAIFTLCEPVGYYVKRNPILYWSSYAVFLVTYLVLACCKEPRRRFPLNIILLSIFTLAMSYMTGTLASFYSTRSVMLCFGITALVCFSVTIFCFQTKFDFTTCHGLLFVLLMALVLTGLVAAIAVPFGYMPWLHVVYGGLGAVVFTLFLAYDTQLLI-GNRRYAISPEEHIFASLNLYMDLVYIFMFLLQIFGSRE 306

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Match: grinaa (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-060616-231])

HSP 1 Score: 138.272 bits (347), Expect = 3.436e-38
Identity = 98/246 (39.84%), Postives = 145/246 (58.94%), Query Frame = 2

Query:  479 QNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            ++PPIY      N S            +T K++R AFIRKVY +L+ Q+                  +V+    LY  + A+  V ++ L C    RRK P NII L   TL  S+M+G+I+   +   V  A  IT+A+ VA+ +F+ QTK DFT  +G LL++ +V + F I  +I+RN ++N++Y  +G L+F++FL VDTQL++ GNH Y++SPE+YIFAALNLY D++ IFL +L I  NS
Sbjct:   47 EHPPIYHDNEDFNIS-----------DWTDKTVRRAFIRKVYLVLTAQL----------------PTYVKSTPGLYYASYAVFFVCLIALSCCGEFRRKHPWNIITLSILTLCMSYMVGMIATFYEADAVVMAMGITVAVCVAVILFSMQTKYDFTSCNGVLLVMLVVLMLFSILCIILRNHILNIVYGALGALLFTVFLAVDTQLLM-GNHKYALSPEEYIFAALNLYTDVINIFLYILMIIGNS 264

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 133.65 bits (335), Expect = 6.311e-37
Identity = 87/222 (39.19%), Postives = 136/222 (61.26%), Query Frame = 2

Query:  566 SKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNR----LVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
             +++R  F+RKVY IL LQ+++T G++A+  F E ++ +V+R   +Y  +  +  V  +VL C T  RR FPLN ILL  FTLA ++M G+++    T+ V     IT  +  A+T+F FQTK DFT   G + +LS+  L  G+ A+          +  +Y  +G ++F++FL  DTQL+LG N  +SISPE++++ AL+LY+DIV IF  +L +F   D
Sbjct:    6 DRNVRRVFVRKVYTILMLQLLVTFGIVAVFTFNESVERFVRRTPAIYWTSYGVFFVTYLVLICCTKARRMFPLNYILLSVFTLAMAYMTGMLASYYSTKSVLMCLGITAMVCAAVTLFCFQTKFDFTSCHGLMFVLSMALLLTGLVAVFTVPFGYIPWIQTVYAGLGAVVFTLFLAFDTQLLLG-NRRHSISPEEHVYGALSLYMDIVYIFTFMLQLFGTRD 226

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 119.783 bits (299), Expect = 8.858e-32
Identity = 84/212 (39.62%), Postives = 126/212 (59.43%), Query Frame = 2

Query:  596 KVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNR----LVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +VY IL +Q+++T G +A+  FV P+K +VQ+N  +Y  +  +     + L C T  RR FPLN ILL   TLA S++ G+++   +T  V     +T A+  A+T+F FQTK+DFT   G +  LS+V L  G+ A           +  +Y  +G +IF++FL VDTQL+L GN   SISPE++I  AL LY+DIV IF  +L +  + +
Sbjct:    8 QVYIILFVQLLVTFGFVAVCTFVVPVKTFVQKNPAMYWASYGVFFATYLGLVCCTKARRLFPLNFILLAVLTLAMSYLTGMLASFYNTNSVLMCIGVTAAVCGAVTLFCFQTKVDFTSCPGVMFALSMVLLLTGLIAAFTVPFGYIPWIQTVYAGLGAVIFTVFLAVDTQLLL-GNRRNSISPEEHINGALRLYMDIVYIFTFLLQLIGSRN 218

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BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002320.1 (pep scaffold:Pmarinus_7.0:GL476639:16633:21901:-1 gene:ENSPMAG00000002114.1 transcript:ENSPMAT00000002320.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.39 bits (285), Expect = 1.238e-30
Identity = 52/97 (53.61%), Postives = 74/97 (76.29%), Query Frame = 2

Query:  917 FAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIF 1207
            F+FQTKIDFT  SG + +  +  L+FG+   I+R+   N+ Y  +G L+F+++L++DTQLM+GG H YS++PE+YIFAALNLY+DIV IFL +L IF
Sbjct:   52 FSFQTKIDFTMKSGIMFVFLMALLSFGLMCAILRSDWANIAYATLGALVFAVYLVIDTQLMMGGKHRYSLNPEEYIFAALNLYIDIVSIFLFILTIF 148

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BLAST of Protein lifeguard 1 vs. Ensembl Yeast
Match: BXI1 (Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p [Source:SGD;Acc:S000005249])

HSP 1 Score: 55.0694 bits (131), Expect = 5.854e-9
Identity = 44/154 (28.57%), Postives = 85/154 (55.19%), Query Frame = 2

Query:  785 NIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKID---------FTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
             + LL  FTL+E++ L +++++ D   V  A +IT  +VV +++ A   + +         + +L+ GL I+  + L   +F     +   NL+Y  +G ++F+ +L +DTQL+        + P++ +  A+ LY+DIV +FL +L I +NS+
Sbjct:  146 KLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFR-----KVYPDEEVRCAMMLYLDIVNLFLSILRILANSN 294

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Nematostella
Match: EDO37574 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFG5])

HSP 1 Score: 161.384 bits (407), Expect = 9.465e-47
Identity = 105/241 (43.57%), Postives = 150/241 (62.24%), Query Frame = 2

Query:  500 YGNPGNASLTNPDSDTAH--FVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            Y   G+A     D   A     F+  SIR  FIRKVY+IL  Q+ +TI  +   L+ EP++L+   +  ++  A+A+  V M+ + C  G RRKFP N++ L  FTL E ++LG +S       V  A  IT  +V+AITIFAFQTK DFT + G L +  IV + FG  A+   NR+V ++Y  +G L+F+++L+ DTQ+M+GG   YSISPE+YIFAALNLY+DIV +FL +L + S +
Sbjct:    5 YNEMGDAEKYGADDPFADNSMAFSDISIRAGFIRKVYSILLCQLAVTISFICFFLYCEPVRLYAVSHPGIFYGALAVTFVTMIAMACCEGVRRKFPTNLLFLTLFTLCEGYLLGAVSSVYKADEVLMAVGITAVVVLAITIFAFQTKYDFTMMGGFLFVALIVLICFGFLAIFFHNRVVQIVYASLGALLFALYLVYDTQIMMGGGKMYSISPEEYIFAALNLYLDIVNMFLYILQLISAA 245

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BLAST of Protein lifeguard 1 vs. Ensembl Nematostella
Match: EDO49375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG77])

HSP 1 Score: 147.517 bits (371), Expect = 9.641e-41
Identity = 116/317 (36.59%), Postives = 165/317 (52.05%), Query Frame = 2

Query:  332 QYPGHPSYGAQPQYPGRPTYSGQPQYSP-TDGGYSIP-----QPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDS-----DTAH---FVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQR-----NKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFA---LIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            QY G P   AQP YP  P   G P Y P    GY  P     QP P+ YP       PP  SY +     L  P S     D  +     F+ KSIR+ FIR+VY IL +Q+ +T+  + L LF +P++ +V       N  +Y+ A  +  VL  V+ C    RRK+P+N+I L  FTLA S+++G IS   DT  V     +T  + +++ IF+ QTK DFT   G L   ++      IF    L++      ++   +  L+F  FL  DTQL++GG   Y +SPE+YIF AL LY+DI++IFL++L +F   
Sbjct:   10 QYGGQPQ-SAQPAYP-PPGGYGNPVYPPPVQPGYQPPPSTGYQPPPESYP----ASFPPPPSYDSAIAKPLEQPSSYGDGYDVEYGGAVSFSDKSIRMGFIRRVYFILMIQLSVTVATICLFLFYKPVRNFVHGKHGAGNTVVYVSAFVVFFVLYFVIACCESVRRKYPVNLICLAIFTLALSYLVGTISSYHDTNIVLIMMGVTTLVCLSVMIFSCQTKYDFTTWGGVLFCAALAIFFLSIFTPVWLLLNTTAGKIVLGGVLALVFVAFLAYDTQLIMGGKK-YELSPEEYIFGALTLYMDIIRIFLLLLALFGKK 319

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Nematostella
Match: EDO48159 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKF0])

HSP 1 Score: 99.3673 bits (246), Expect = 5.222e-24
Identity = 73/218 (33.49%), Postives = 126/218 (57.80%), Query Frame = 2

Query:  563 TSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQ-RNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSN 1213
            T+ ++RL F+RKVY ILS Q+ +TI + AL +    IK +VQ R + L++  I     L+         RR+ P+N+ LL  FTL E++ LG +    D   V  A  +T A  +A+T++  Q+K D++    GL  +  +F+  G+  +  ++ ++ L Y  +G L+FS F++ DT +++       +SPE+YI A++NLY+DI+ +F+ +L I  +
Sbjct:   17 TNINVRLGFLRKVYGILSAQLGLTILVSALFMSTPAIKDFVQSRPEVLFVAFILSFGFLI----ALMFKRRESPMNMYLLFGFTLVEAYTLGTLVTFFDRMIVLEAFGMTAATTIALTMYTLQSKRDYSSWGAGLFTMLWIFIWAGLLQMFFQSDILELAYAVLGALLFSAFIVFDTHMLMN-----KMSPEEYILASINLYMDIINLFIQILKILES 225

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Match: grinaa (protein lifeguard 1 [Source:NCBI gene;Acc:101164659])

HSP 1 Score: 162.925 bits (411), Expect = 6.316e-46
Identity = 118/306 (38.56%), Postives = 174/306 (56.86%), Query Frame = 2

Query:  335 YPGHPSYGAQPQYP-GRPTYSGQPQYSPTDGGYSIPQ-PRPQVYPYGSQLQNP--PIYSYGNPGNASLTNPDS-----DTAHFV---FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            YP   SYG QP +P   P ++  P Y P       PQ P PQ  PY      P  P+   G P ++   + D      D   F       K++R AFIRKV+ +L++Q+V+T   +A+  F +  K++V+RN ++Y  + A  +V ++ L C    RRK+P N I L   TL+ S+M+G+I+   DT  V  A  IT  +   + +F+ QTK DFT   G L +  IV + F I  + +RN++++L+Y  +G L+F+ FL VDTQL+L GN + ++SPE+YIFAALNLY DI+ IFL +L I   S
Sbjct:   45 YPPAGSYG-QPGFPQAGPGFAPGP-YPPM----GFPQMPYPQG-PYQQGFGQPGFPVDPMGVPADSPAYHDDGPPSYGDNDEFKIGGLEDKTVRRAFIRKVFLVLTVQLVVTFSFVAIFTFSDDAKIFVRRNPWVYYTSYASFLVCLIALSCCGDFRRKYPGNFIALGILTLSLSYMVGMIASFYDTETVIIAVGITAGVCFTVVLFSLQTKYDFTSCRGVLFVCLIVLMIFSILCIFIRNKIMHLVYASLGALLFTCFLAVDTQLLL-GNKNLALSPEEYIFAALNLYTDIINIFLYILAIVGRS 342

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:101159382])

HSP 1 Score: 159.844 bits (403), Expect = 8.129e-45
Identity = 102/219 (46.58%), Postives = 145/219 (66.21%), Query Frame = 2

Query:  575 IRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            +R +FIRKVY IL+ Q+++T  ++A+  FV P+K +V+ N  +Y  + AI I+  +VL C  GPRRK+P N+ILLL FTLA S+M G IS   DT+ V  A  IT  + +A+T+F FQTK+DFT   G   +L IV    GI A I+ +      ++++Y  IG ++F++FL   TQL++G N  YSIS E+Y+FAAL++YVDIVQIFL +L I   S 
Sbjct:  118 VRHSFIRKVYLILASQLLLTTAIVAIFTFVHPVKTFVRDNPAVYWASYAIYIITHIVLVCCKGPRRKYPWNLILLLIFTLALSYMTGTISSFYDTKSVFLALGITAVVCIAVTVFCFQTKVDFTKCQGLFCVLGIVVFVTGIIAAIVLSFKYILWLHMLYAAIGAIVFTLFLAYHTQLLIG-NRKYSISEEEYVFAALSIYVDIVQIFLFLLQIIGASK 335

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Match: grinab (protein lifeguard 1 [Source:NCBI gene;Acc:101161330])

HSP 1 Score: 157.918 bits (398), Expect = 5.527e-44
Identity = 105/274 (38.32%), Postives = 158/274 (57.66%), Query Frame = 2

Query:  401 PQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNA----SLTNPDSDTAHFV--FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGI 1204
            P Y     GY  P   P   P        P++S    G+A        P  D   F+    +KSIR AF+RKV+ +L+ Q+++T   +A+  FV+ +K +V+ N + YIV+  I IV ++ + C    RRK P N++ L   TL+ S+M+G+I+   DT  V  A  IT  +   + IF+ QTK DFT   G L +  IV + FG   + ++N+++ ++Y  +G L+F+ FL VDTQL+L GN   S+SPE+Y+FAALNLY+DI+ IFL +L I
Sbjct:   67 PSYGMISRGYDNPCSEPYSSP-------DPVFSNTYGGDAYHGEEAPPPFHDNQDFMIGLDNKSIRRAFVRKVFLVLTAQLMVTFAFVAIFTFVKEVKAFVKVNIWTYIVSYVIFIVALLAISCCGNLRRKHPWNLVALSILTLSMSYMVGMIASFHDTDSVIMAVGITAVVCFTVVIFSLQTKYDFTSCYGVLFVCLIVLIIFGFLCIFIQNKILEIVYAGLGALLFTCFLAVDTQLLL-GNKELSLSPEEYVFAALNLYLDIINIFLYILAI 332

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Match: tmbim1b (protein lifeguard 3-like [Source:NCBI gene;Acc:101175308])

HSP 1 Score: 153.295 bits (386), Expect = 1.427e-42
Identity = 113/300 (37.67%), Postives = 174/300 (58.00%), Query Frame = 2

Query:  347 PSYGAQPQYPGRPTYSGQP--QYSPTDGGYSIP---QPRPQVYPYGSQLQ--NPPIYSYGNPGNASLTNPDSDTAHFV---FTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRN----RLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGI 1204
            PSY     +P     S QP   YSP+ G Y  P     +  V+P  S+    +P + +      A       D   F    + S S+R AFIRKVY IL++Q+  T  ++A+  FV+P++L+V R   +Y  ++A+  V+  VL C   PRR+FP N++LL  FTLA S+M G IS   +T+ V  A  IT+ + VA+T+F FQTK+D T  SG L I  ++ +  GI   ++ +      ++++Y  IG +++++FL+ +TQL++G N   +ISPE+Y+F AL+LYVDIV IFL +L +
Sbjct:    9 PSYEEALHHPKAEDCSYQPPPSYSPSTGMYPGPPGYWSQGGVFPQTSESPGLSPTVTTIPTLSAAVPAAHTGDMEAFFRNQWESTSVRHAFIRKVYLILAVQLAFTFTVVAVFTFVDPVRLFVIRYPGIYWASLAVYFVVYCVLICLKEPRRRFPWNLLLLGIFTLALSYMAGTISSYYETKAVFIAMGITVVVCVAVTVFCFQTKVDLTSCSGLLCIAGVLLMIIGIVTAVVLSFQYVHWLHMLYAAIGAVVYTLFLVYNTQLLIG-NRELAISPEEYVFGALSLYVDIVHIFLFILQV 307

[Close]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Match: faim2b (protein lifeguard 2-like [Source:NCBI gene;Acc:101164304])

HSP 1 Score: 137.502 bits (345), Expect = 2.778e-37
Identity = 94/239 (39.33%), Postives = 144/239 (60.25%), Query Frame = 2

Query:  482 NPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIM----RNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIF 1186
             PP Y     G   +       A F +  K+IR  FIRKVYAIL LQ+ +T+G+++L  F  P++ ++Q +  LY+++  + +V  ++L C    RRKFP N +LLL FTL+ +FM+G +S   +T+ V     IT  + +++TIF+FQ+KID T   G L  + +  L   I   I+        ++ IY  IG ++F++FL  DTQL+L GN  YSISPE+YIFA L+LY+D++ +F
Sbjct:   11 EPPSYQEATAGYGEME------AQFAWDDKTIRRTFIRKVYAILMLQLSVTVGIVSLFTFCAPVRFYIQTHPNLYMMSYVMFLVTYIMLSCCGDLRRKFPWNALLLLLFTLSMAFMMGFVSSFYNTKSVILCLGITTLVCLSVTIFSFQSKIDVTSYQGVLFSMCMAMLLCAITISIVVPFGYVPWLHAIYAVIGAILFTLFLAFDTQLLL-GNKRYSISPEEYIFATLSLYLDVIYLF 242

[Close]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Match: SMESG000014373.1 (SMESG000014373.1)

HSP 1 Score: 546.969 bits (1408), Expect = 0.000e+0
Identity = 340/341 (99.71%), Postives = 340/341 (99.71%), Query Frame = 2

Query:  197 MSMDQRYPQYLSQGVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            MSMDQRYPQYLSQGVQQQYPP GAQQQYPPQGAQQQYPGNYAGTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD
Sbjct:    1 MSMDQRYPQYLSQGVQQQYPPPGAQQQYPPQGAQQQYPGNYAGTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 341

[Close]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Match: SMESG000014373.1 (SMESG000014373.1)

HSP 1 Score: 543.117 bits (1398), Expect = 0.000e+0
Identity = 338/339 (99.71%), Postives = 338/339 (99.71%), Query Frame = 2

Query:  203 MDQRYPQYLSQGVXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            MDQRYPQYLSQGVQQQYPP GAQQQYPPQGAQQQYPGNYAGTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD
Sbjct:    1 MDQRYPQYLSQGVQQQYPPPGAQQQYPPQGAQQQYPGNYAGTPQYPGHPSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 339

[Close]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Match: SMESG000057144.1 (SMESG000057144.1)

HSP 1 Score: 153.295 bits (386), Expect = 7.040e-43
Identity = 113/264 (42.80%), Postives = 164/264 (62.12%), Query Frame = 2

Query:  443 PRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFG-----IFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 1219
            P+PQVY Y +    PP    G+     +   D+  A   F+ KS+R  FIRKVY I++ Q+++T   +A+  FVEPI+ WV+RN + Y ++ AI IV  + L C  G RRK+P N   L  FTLA S+M   I+   +T  V  A  IT  + ++ITIFA QTKIDFT  SG +L+LS+V L  G     I+A +  +++V+ +Y  + +L+F I+L+ DTQL++GG   Y +SPEDYI  AL LY+DIV +FL++L +F N +
Sbjct:   49 PQPQVYNYQATEPQPPYQGAGD-----MYGGDNFAA---FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMILVLSLVLLLTGLSCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 303

[Close]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Match: SMESG000014372.1 (SMESG000014372.1)

HSP 1 Score: 145.206 bits (365), Expect = 1.712e-39
Identity = 95/287 (33.10%), Postives = 161/287 (56.10%), Query Frame = 2

Query:  353 YGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSN 1213
            Y  QP  P    Y+  PQ        +IP   P+   YG  L+N  I            + DSD   F+  SK+ R AFI+ VY +L++Q++ T+ ++ +M FV  IK W+        V   +  + ++++G     RRKFP N +LL +FT+    +LG++++   ++ + Y+ V+   I++   +F FQ K D TYL+G L++L +V L F +  L++   ++ +IYC +GV+++S+ LLV+TQL+L G H Y IS  +++F  LNLY++ +   +M+ G+F N
Sbjct:   58 YLNQPVVP--ENYARDPQLWSGTSTMTIPGASPRTLVYG--LRNADI------------SQDSDDVKFL--SKADRYAFIKWVYGLLTIQILFTVFIIVIMCFVNAIKNWLLTQSCFLWVFSLLAFLQILIIGFCPITRRKFPTNYLLLESFTITVGCILGMVTVFMTSKILFYSIVLIAFIIIVSFVFGFQNKYDLTYLTGSLIVLLVVALGFIVGLLLIGYDVITMIYCVVGVILYSVMLLVETQLILEGYHVYIISQNEHVFVTLNLYLNAIHSMIMLSGVFCN 326

[Close]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Match: SMESG000027408.1 (SMESG000027408.1)

HSP 1 Score: 80.1073 bits (196), Expect = 6.418e-17
Identity = 75/218 (34.40%), Postives = 125/218 (57.34%), Query Frame = 2

Query:  572 SIRLAFIRKVYAILSLQ--MVITIGLMALMLFVEPIKLWVQRNKYLYXXXXXXXXXXXXXXGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYXXXXXXXXXXXXXXXXXFAFQTKIDFTYLSGGLLILSIVFLAF-GIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNS 1216
            SIRL F+RKVY ILS+Q  M   IG + +M+F E ++ +++ N ++  + + + IV+++ +      R+  P N + L  FTL ES  +G I I      V  + V+TL + V++TI+ FQTK DF+    GL    +V L F GI  L +++  + +I    G  +FS+ ++ DT + +     + +S E+YI A ++LY+DI+ +FL +L I   S
Sbjct:   24 SIRLGFLRKVYGILSVQLGMTTVIGCI-MMMFQESVRSFLKDNAWILFLCLILNIVVLITMFVL---RKTTPHNFLCLFLFTLIESITVGFIIIQYQVAAVLISLVLTLLVSVSLTIYTFQTKRDFSTWGAGLFA-GLVILCFGGIIQLFVKSSGLEIILAIGGAFLFSMLIIYDTWMAI-----HRLSAEEYILACIDLYLDIINLFLHILRIVGAS 231

The following BLAST results are available for this feature:

BLAST of Protein lifeguard 1 vs. Ensembl Human
BLAST of Protein lifeguard 1 vs. Ensembl Celegans
BLAST of Protein lifeguard 1 vs. Ensembl Fly
BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
BLAST of Protein lifeguard 1 vs. Ensembl Mouse
BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
BLAST of Protein lifeguard 1 vs. TrEMBL
BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
BLAST of Protein lifeguard 1 vs. Ensembl Yeast
BLAST of Protein lifeguard 1 vs. Ensembl Nematostella
BLAST of Protein lifeguard 1 vs. Ensembl Medaka
BLAST of Protein lifeguard 1 vs. Planmine SMEST

BLAST of Protein lifeguard 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GRINA	4.033e-46	38.60	glutamate ionotropic receptor NMDA type subunit as...	[more]
GRINA	4.033e-46	38.60	glutamate ionotropic receptor NMDA type subunit as...	[more]
TMBIM1	4.228e-44	38.64	transmembrane BAX inhibitor motif containing 1 [So...	[more]
TMBIM1	4.228e-44	38.64	transmembrane BAX inhibitor motif containing 1 [So...	[more]
TMBIM1	4.228e-44	38.64	transmembrane BAX inhibitor motif containing 1 [So...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
xbx-6	3.734e-35	34.64	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	3.734e-35	34.64	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	3.734e-35	34.64	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	7.602e-34	33.93	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	7.602e-34	33.93	X-BoX promoter element regulated [Source:UniProtK...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nmda1	4.961e-53	44.94	gene:FBgn0013305 transcript:FBtr0089877	[more]
Nmda1	4.961e-53	44.94	gene:FBgn0013305 transcript:FBtr0089873	[more]
Nmda1	4.961e-53	44.94	gene:FBgn0013305 transcript:FBtr0089875	[more]
Nmda1	9.153e-53	44.94	gene:FBgn0013305 transcript:FBtr0089876	[more]
Nmda1	9.153e-53	44.94	gene:FBgn0013305 transcript:FBtr0309295	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grinab	1.113e-49	41.79	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
grinab	3.721e-49	41.73	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
zgc:110410	7.216e-48	37.42	zgc:110410 [Source:ZFIN;Acc:ZDB-GENE-050522-465]	[more]
grinaa	3.662e-46	37.73	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
tmbim1a	1.005e-45	41.78	transmembrane BAX inhibitor motif containing 1a [S...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grina	9.721e-52	40.46	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
grina	9.721e-52	40.46	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
tmbim1	1.829e-45	38.05	transmembrane BAX inhibitor motif containing 1 [So...	[more]
faim2	2.347e-44	37.29	Fas apoptotic inhibitory molecule 2 [Source:NCBI g...	[more]
grina	9.437e-41	38.03	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tmbim1	5.441e-43	38.01	transmembrane BAX inhibitor motif containing 1 [So...	[more]
Tmbim1	5.441e-43	38.01	transmembrane BAX inhibitor motif containing 1 [So...	[more]
Grina	1.871e-42	40.57	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
Tmbim7	3.406e-39	36.29	transmembrane BAX inhibitor motif containing 7 [So...	[more]
Faim2	3.418e-39	34.11	Fas apoptotic inhibitory molecule 2 [Source:MGI Sy...	[more]

BLAST of Protein lifeguard 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q7Z429\|LFG1_HUMAN	1.937e-45	38.60	Protein lifeguard 1 OS=Homo sapiens OX=9606 GN=GRI...	[more]
sp\|Q969X1\|LFG3_HUMAN	2.030e-43	38.64	Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMB...	[more]
sp\|Q9ESF4\|LFG1_MOUSE	1.309e-41	40.57	Protein lifeguard 1 OS=Mus musculus OX=10090 GN=Gr...	[more]
sp\|Q6P6R0\|LFG1_RAT	2.923e-41	40.38	Protein lifeguard 1 OS=Rattus norvegicus OX=10116 ...	[more]
sp\|Q8BJZ3\|LFG3_MOUSE	8.009e-41	37.33	Protein lifeguard 3 OS=Mus musculus OX=10090 GN=Tm...	[more]

BLAST of Protein lifeguard 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267FI04	1.951e-61	53.33	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A212FK47	1.406e-59	51.05	Uncharacterized protein OS=Danaus plexippus plexip...	[more]
H9JQS1	1.353e-58	47.04	Uncharacterized protein OS=Bombyx mori OX=7091 PE=...	[more]
Q2F693	3.083e-58	47.04	Glutamate receptor Gr1 OS=Bombyx mori OX=7091 PE=2...	[more]
Q2F692	3.659e-58	47.04	Glutamate receptor Gr2 OS=Bombyx mori OX=7091 PE=2...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grinab	3.597e-48	38.02	protein lifeguard 1-like [Source:NCBI gene;Acc:103...	[more]
grinab	7.099e-46	36.71	protein lifeguard 1-like [Source:NCBI gene;Acc:103...	[more]
zgc:110410	8.365e-45	39.42	protein lifeguard 1-like [Source:NCBI gene;Acc:111...	[more]
tmbim1a	1.994e-44	43.30	transmembrane BAX inhibitor motif containing 1 [So...	[more]
grinaa	9.148e-44	37.13	glutamate ionotropic receptor NMDA type subunit as...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
faim2a	5.633e-45	40.63	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
grinaa	3.436e-38	39.84	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
faim2a	6.311e-37	39.19	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
faim2a	8.858e-32	39.62	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
ENSPMAT00000002320.1	1.238e-30	53.61	pep scaffold:Pmarinus_7.0:GL476639:16633:21901:-1 ...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
BXI1	5.854e-9	28.57	Protein involved in apoptosis; variously described...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO37574	9.465e-47	43.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49375	9.641e-41	36.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48159	5.222e-24	33.49	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein lifeguard 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grinaa	6.316e-46	38.56	protein lifeguard 1 [Source:NCBI gene;Acc:10116465...	[more]
tmbim1a	8.129e-45	46.58	transmembrane BAX inhibitor motif containing 1 [So...	[more]
grinab	5.527e-44	38.32	protein lifeguard 1 [Source:NCBI gene;Acc:10116133...	[more]
tmbim1b	1.427e-42	37.67	protein lifeguard 3-like [Source:NCBI gene;Acc:101...	[more]
faim2b	2.778e-37	39.33	protein lifeguard 2-like [Source:NCBI gene;Acc:101...	[more]

BLAST of Protein lifeguard 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000014373.1	0.000e+0	99.71	SMESG000014373.1	[more]
SMESG000014373.1	0.000e+0	99.71	SMESG000014373.1	[more]
SMESG000057144.1	7.040e-43	42.80	SMESG000057144.1	[more]
SMESG000014372.1	1.712e-39	33.10	SMESG000014372.1	[more]
SMESG000027408.1	6.418e-17	34.40	SMESG000027408.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30000477 ID=SMED30000477|Name=Protein lifeguard 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1338bp
CAGAGGTAGGGAGTATTCATTAGTCGACCCAAAATGAATGTGTAAACACA
CTCGTGGGAAATTAATAAAATTAATAAATGAATTCATTTAATTAATCGAT
TGAAATATTGATTGGGATAGTTATGAAGCAGAATGAAATATGTGCACTTG
TCCGTGATTCTAACTCCATTGGCCCCATGAAGATGTCCGCGATTTGATGT
CCATGGATCAAAGATATCCGCAATACCTCTCTCAAGGAGTTCAGCAGCAA
TATCCCCCACTAGGAGCTCAGCAGCAATACCCCCCTCAAGGAGCTCAGCA
ACAATATCCTGGAAATTATGCAGGGACCCCTCAATATCCTGGACATCCTT
CCTATGGAGCTCAGCCTCAATATCCCGGACGTCCTACCTATAGTGGCCAG
CCTCAATATTCACCAACGGATGGGGGGTACTCAATACCCCAGCCGCGCCC
TCAAGTTTATCCTTACGGCTCTCAGCTTCAAAACCCTCCAATATATTCTT
ATGGGAACCCTGGAAATGCCTCCTTGACCAATCCCGACAGTGATACTGCC
CATTTCGTGTTCACCTCGAAATCTATTCGACTTGCTTTTATTAGAAAGGT
TTATGCGATCCTATCCTTGCAAATGGTAATCACGATCGGATTGATGGCGC
TGATGCTGTTTGTTGAACCGATCAAACTTTGGGTACAGAGAAATAAATAT
TTATACATTGTCGCCATAGCGATTGTTATAGTTCTAATGGTCGTGCTTGG
ATGTTTCACCGGGCCCCGCAGAAAATTCCCATTGAACATAATTCTCTTAT
TGGCATTTACCCTGGCTGAAAGCTTCATGCTTGGAGTAATTTCAATTTCG
AAGGACACGAGATATGTCGCATACGCAACGGTCATTACACTGGCCATTGT
AGTTGCGATTACAATATTCGCATTCCAGACAAAGATCGACTTCACCTATT
TGTCCGGTGGCTTGTTAATTCTTTCCATTGTATTCTTAGCTTTCGGAATT
TTCGCCCTAATTATGAGAAACAGGCTGGTCAACCTTATCTACTGTTGTAT
TGGAGTTTTGATCTTTTCAATTTTTCTGCTCGTTGACACTCAACTCATGC
TTGGGGGTAATCACTCATACAGCATATCGCCCGAGGATTATATATTTGCC
GCGTTGAACTTATATGTGGATATCGTGCAAATCTTCCTAATGGTTCTTGG
AATATTCTCCAACAGCGATTGACGAGGAGAATATTCTATATTTGTCCAGG
AATCTGTGGAAGCTAGGCCCACCTCTTTCCTTTCTATTGTATCTAATAAT
TATTTAGTGATATTTAATAAAAGTTATTTGACTTTAAA

protein sequence of SMED30000477-orf-1

>SMED30000477-orf-1 ID=SMED30000477-orf-1|Name=SMED30000477-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=342bp
MSMDQRYPQYLSQGVQQQYPPLGAQQQYPPQGAQQQYPGNYAGTPQYPGH
PSYGAQPQYPGRPTYSGQPQYSPTDGGYSIPQPRPQVYPYGSQLQNPPIY
SYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLM
ALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIIL
LLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFT
YLSGGLLILSIVFLAFGIFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQL
MLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000419	prepharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR006214	Bax_inhibitor_1-related

Vocabulary: **cellular component**
Term	Definition
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **biological process**
Term	Definition
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Vocabulary: **molecular function**
Term	Definition
GO:0044325	ion channel binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006214	Bax inhibitor 1-related	PFAM	PF01027	Bax1-I	coord: 130..337 e-value: 1.0E-36 score: 126.7
IPR006214	Bax inhibitor 1-related	PANTHER	PTHR23291	BAX INHIBITOR-RELATED	coord: 52..339
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..57
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..42
None	No IPR available	PANTHER	PTHR23291:SF81	X-BOX PROMOTER ELEMENT REGULATED	coord: 52..339
None	No IPR available	CDD	cd10428	LFG_like	coord: 122..337 e-value: 1.73103E-90 score: 267.87
None	No IPR available	TMHMM	TMhelix		coord: 194..216
None	No IPR available	TMHMM	TMhelix		coord: 315..337
None	No IPR available	TMHMM	TMhelix		coord: 223..245
None	No IPR available	TMHMM	TMhelix		coord: 278..300
None	No IPR available	TMHMM	TMhelix		coord: 168..190
None	No IPR available	TMHMM	TMhelix		coord: 249..271
None	No IPR available	TMHMM	TMhelix		coord: 135..156