Bromodomain-containing protein 8
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30000474 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]) HSP 1 Score: 99.3673 bits (246), Expect = 2.290e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]) HSP 1 Score: 99.3673 bits (246), Expect = 2.291e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]) HSP 1 Score: 99.3673 bits (246), Expect = 2.451e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 14 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 136
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]) HSP 1 Score: 99.3673 bits (246), Expect = 2.468e-21 Identity = 51/119 (42.86%), Postives = 76/119 (63.87%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLD 514 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMD 135
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]) HSP 1 Score: 99.3673 bits (246), Expect = 2.533e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 13 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 135
BLAST of Bromodomain-containing protein 8 vs. Ensembl Fly
Match: Brd8 (gene:FBgn0039654 transcript:FBtr0085394) HSP 1 Score: 67.781 bits (164), Expect = 1.413e-11 Identity = 46/138 (33.33%), Postives = 77/138 (55.80%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSF---GSSQRKDDKSWCSSKECAKQYSKLLDNIEKKKR-----SDNNNSTLPL-----KELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDES-VPEIW 535 WS RE+L LASAV +G + W ++SR +++ GSS R D W S K CA QY LL+++E KR + + P EL++++LT ER E++ +R +QE ++ + +L+S ++ E + ++W Sbjct: 19 WSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPAD--WFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMW 154
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10]) HSP 1 Score: 107.071 bits (266), Expect = 4.750e-24 Identity = 54/127 (42.52%), Postives = 84/127 (66.14%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538 WS+REKL LAS+V+ +G + W S+SR I+ F S R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+ +I++ QEK LK ++ +++G +D + E+W+ Sbjct: 10 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWA 134
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10]) HSP 1 Score: 107.071 bits (266), Expect = 5.093e-24 Identity = 54/127 (42.52%), Postives = 84/127 (66.14%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538 WS+REKL LAS+V+ +G + W S+SR I+ F S R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+ +I++ QEK LK ++ +++G +D + E+W+ Sbjct: 10 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWA 134
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54]) HSP 1 Score: 106.301 bits (264), Expect = 7.128e-24 Identity = 62/165 (37.58%), Postives = 97/165 (58.79%), Query Frame = 2 Query: 146 LPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634 L + WS+REKL LAS+V+++G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+ +I++ QEK LK +++G LD + E+W + I+ + K + E E++ + TDA Sbjct: 12 LGPTDPWSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKRLIKDTQEKHRKLKRESELIQAGHLDSKLEELW----------EEIVRSRKQEEEEAEVKRKATDA 164
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54]) HSP 1 Score: 106.301 bits (264), Expect = 7.631e-24 Identity = 61/161 (37.89%), Postives = 95/161 (59.01%), Query Frame = 2 Query: 158 NEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634 + WS+REKL LAS+V+++G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+ +I++ QEK LK +++G LD + E+W I+ + K + E E++ + TDA Sbjct: 16 DPWSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKRLIKDTQEKHRKLKRESELIQAGHLDSKLEELWEE----------IVRSRKQEEEEAEVKRKATDA 164
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036]) HSP 1 Score: 103.99 bits (258), Expect = 1.067e-23 Identity = 55/126 (43.65%), Postives = 80/126 (63.49%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ERIEEL+++I+ QEK LK ++SG LD + ++W Sbjct: 18 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 141
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036]) HSP 1 Score: 104.76 bits (260), Expect = 4.202e-23 Identity = 55/126 (43.65%), Postives = 80/126 (63.49%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ERIEEL+++I+ QEK LK ++SG LD + ++W Sbjct: 16 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 139
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036]) HSP 1 Score: 83.1889 bits (204), Expect = 2.903e-16 Identity = 45/113 (39.82%), Postives = 68/113 (60.18%), Query Frame = 2 Query: 203 IETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 + +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ERIEEL+++I+ QEK LK ++SG LD + ++W Sbjct: 1 MRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 111
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906]) HSP 1 Score: 99.3673 bits (246), Expect = 1.902e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906]) HSP 1 Score: 99.3673 bits (246), Expect = 1.903e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906]) HSP 1 Score: 99.3673 bits (246), Expect = 1.958e-21 Identity = 51/119 (42.86%), Postives = 76/119 (63.87%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLD 514 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMD 135
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906]) HSP 1 Score: 98.9821 bits (245), Expect = 1.984e-21 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Match: sp|Q8R3B7|BRD8_MOUSE (Bromodomain-containing protein 8 OS=Mus musculus OX=10090 GN=Brd8 PE=1 SV=2) HSP 1 Score: 99.3673 bits (246), Expect = 1.331e-20 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Match: sp|Q9H0E9|BRD8_HUMAN (Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2) HSP 1 Score: 98.9821 bits (245), Expect = 1.718e-20 Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532 WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL++VI+ QE+ LK +++G +D + E+ Sbjct: 19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: A0A2G8JPT2 (Putative bromodomain-containing protein 8 OS=Stichopus japonicus OX=307972 GN=BSL78_25380 PE=4 SV=1) HSP 1 Score: 107.457 bits (267), Expect = 1.227e-22 Identity = 58/139 (41.73%), Postives = 91/139 (65.47%), Query Frame = 2 Query: 143 KLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPL-KELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKD 550 K P EWS+REKL LASAV+ +G + W S+SR I+ F R D W + K CA QYS +L+ ++ K+KRS + + +LIVKK+T +R+EEL++++ ++++K L+D + +ESG+LDE +PEI +K+ Sbjct: 4 KTPPCQEWSIREKLCLASAVMRSGDQNWMSVSRAIKPFPEPGRPSD--WNTPKNCAIQYSSMLNEVDTPKRKRSGDKGDVVETPGDLIVKKMTFDRVEELKQMLADDRKKFKLLRDEIELIESGALDEKLPEILQDIKE 140
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: S4RHS1 (Bromo domain-containing protein OS=Petromyzon marinus OX=7757 PE=4 SV=1) HSP 1 Score: 111.694 bits (278), Expect = 3.518e-22 Identity = 63/144 (43.75%), Postives = 88/144 (61.11%), Query Frame = 2 Query: 110 HSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 H LQ + EE WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IVKKLTVERIEEL + IR+ Q++ LK L +++G LD ++ EIW Sbjct: 8 HKLQNVGPQEE-------WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETIEDVIVKKLTVERIEELTKSIRDIQDRYKKLKHELELVQNGQLDHNLHEIW 142
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: W5KE27 (Uncharacterized protein OS=Astyanax mexicanus OX=7994 PE=4 SV=2) HSP 1 Score: 106.301 bits (264), Expect = 1.250e-21 Identity = 61/159 (38.36%), Postives = 95/159 (59.75%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634 WS+REKL LAS+V+++G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+++I++ QEK LK +++G LD + E+W I++ K + E E++ + TDA Sbjct: 16 WSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLECTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKKLIKDTQEKHRKLKREAELIQAGHLDSRLDELWGD----------IVQNRKQEEEEAEVKRKATDA 162
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: T1FUX7 (Bromo domain-containing protein OS=Helobdella robusta OX=6412 GN=20212623 PE=4 SV=1) HSP 1 Score: 109.383 bits (272), Expect = 1.780e-21 Identity = 63/150 (42.00%), Postives = 87/150 (58.00%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEI 613 WS REKL+LASAV+ +G + W S+SR I+ F R D W S CA+QY +LLD +E KR ++IVKKLT ERIEEL+ +I+ + EK LK+ L ++SG L + + EIWS+L Q +E D P +E+ Sbjct: 18 WSTREKLSLASAVMRSGDQNWVSVSRSIRPFLEPGRCSD--WFSQINCARQYEELLDKVETPKRKRGEKDVERPGDVIVKKLTAERIEELKVLIQQQAEKYRTLKNELEKIKSGQLQDQIKEIWSKLSQEKTNKQLPVEEDSVFPPYLEL 165
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: A0A2D4EXR2 (Uncharacterized protein (Fragment) OS=Micrurus corallinus OX=54390 PE=4 SV=1) HSP 1 Score: 101.293 bits (251), Expect = 2.206e-21 Identity = 54/126 (42.86%), Postives = 81/126 (64.29%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 WS+REKL LAS+V+ +G + W S+SR I+ F S R D W S K CA QYS+LL+ E K+KR + ++++IV+KLT ER+EEL+++I+ QEK LK +++G +D + EI+ Sbjct: 36 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAESGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETIEDVIVRKLTAERVEELKKLIKETQEKYRQLKRDAELIQAGHIDHRLEEIY 159
BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54]) HSP 1 Score: 106.301 bits (264), Expect = 4.734e-25 Identity = 61/159 (38.36%), Postives = 95/159 (59.75%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634 WS+REKL LAS+V+++G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERIEEL+++I++ QEK LK +++G LD + E+W I++ K + E E++ + TDA Sbjct: 16 WSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLECTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKKLIKDTQEKHRKLKREAELIQAGHLDSRLDELWGD----------IVQNRKQEEEEAEVKRKATDA 162
BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10]) HSP 1 Score: 83.1889 bits (204), Expect = 1.863e-16 Identity = 42/114 (36.84%), Postives = 72/114 (63.16%), Query Frame = 2 Query: 203 IETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538 + +G + W S+SR I+ F S R D W S K CA QYS+LL+ E K+KR + ++++IV++LT ERI+EL++++++ QEK LK ++ +++G +D + E+W Sbjct: 1 MRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETIEDVIVRRLTTERIDELKKLLKDTQEKYRKLKKEVDLIQAGHMDSKLEELWG 112
BLAST of Bromodomain-containing protein 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004772.1 (pep scaffold:Pmarinus_7.0:GL477964:1616:15578:1 gene:ENSPMAG00000004315.1 transcript:ENSPMAT00000004772.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 111.694 bits (278), Expect = 2.703e-26 Identity = 63/144 (43.75%), Postives = 88/144 (61.11%), Query Frame = 2 Query: 110 HSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535 H LQ + EE WS+REKL LAS+V+ +G + W S+SR I+ F R D W S K CA QYS+LL+ E K+KR + ++++IVKKLTVERIEEL + IR+ Q++ LK L +++G LD ++ EIW Sbjct: 8 HKLQNVGPQEE-------WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETIEDVIVKKLTVERIEELTKSIRDIQDRYKKLKHELELVQNGQLDHNLHEIW 142
BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Match: ENSORLT00000036108.1 (pep primary_assembly:ASM223467v1:10:26393229:26394899:-1 gene:ENSORLG00000025104.1 transcript:ENSORLT00000036108.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 65.0846 bits (157), Expect = 6.279e-13 Identity = 33/63 (52.38%), Postives = 41/63 (65.08%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKK 352 WSVREKL LAS+V+ +G + W S+SR I+ F S R D W S K CA QYS+LL+ E K Sbjct: 19 WSVREKLCLASSVMRSGDQNWVSVSRAIKPFAESGRPPD--WFSQKHCASQYSELLEATEAPK 79
BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Match: ENSORLT00000031288.1 (pep primary_assembly:ASM223467v1:14:13811011:13812698:-1 gene:ENSORLG00000025967.1 transcript:ENSORLT00000031288.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 60.4622 bits (145), Expect = 1.923e-11 Identity = 29/63 (46.03%), Postives = 41/63 (65.08%), Query Frame = 2 Query: 164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKK 352 W+VREKL LA++V+++G + W S+SR I+ F R D W S K CA +YS+LL+ E K Sbjct: 19 WTVREKLCLATSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASKYSELLETTEAPK 79
BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Match: SMESG000045604.1 (SMESG000045604.1) HSP 1 Score: 424.091 bits (1089), Expect = 7.331e-147 Identity = 236/244 (96.72%), Postives = 240/244 (98.36%), Query Frame = 2 Query: 545 KDNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYVSSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKXXXXXXXXXXXXXXXXXXXXKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLECLYETDD 1276 K+NDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIY+SSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLE + + D Sbjct: 87 KNNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYISSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLEVIIDLFD 330 HSP 2 Score: 179.489 bits (454), Expect = 7.005e-52 Identity = 87/87 (100.00%), Postives = 87/87 (100.00%), Query Frame = 2 Query: 86 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 346 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK Sbjct: 1 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 87
BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Match: SMESG000037340.1 (SMESG000037340.1) HSP 1 Score: 422.935 bits (1086), Expect = 2.252e-146 Identity = 235/244 (96.31%), Postives = 240/244 (98.36%), Query Frame = 2 Query: 545 KDNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYVSSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKXXXXXXXXXXXXXXXXXXXXKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLECLYETDD 1276 K+NDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIEL+DEIEAKSPKIESDKESNNSCETEPAIY+SSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLE + + D Sbjct: 87 KNNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELNDEIEAKSPKIESDKESNNSCETEPAIYISSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLEVIIDLFD 330 HSP 2 Score: 179.874 bits (455), Expect = 5.742e-52 Identity = 87/87 (100.00%), Postives = 87/87 (100.00%), Query Frame = 2 Query: 86 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 346 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK Sbjct: 1 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 87 The following BLAST results are available for this feature:
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Bromodomain-containing protein 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Bromodomain-containing protein 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 3
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 2
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Bromodomain-containing protein 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Bromodomain-containing protein 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Bromodomain-containing protein 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30000474 ID=SMED30000474|Name=Bromodomain-containing protein 8|organism=Schmidtea mediterranea sexual|type=transcript|length=1472bpback to top protein sequence of SMED30000474-orf-1 >SMED30000474-orf-1 ID=SMED30000474-orf-1|Name=SMED30000474-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=419bp MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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