Bromodomain-containing protein 8

Overview
NameBromodomain-containing protein 8
Smed IDSMED30000474
Length (bp)1472
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bromodomain-containing protein 8 (SMED30000474) t-SNE clustered cells

Violin plots show distribution of expression levels for Bromodomain-containing protein 8 (SMED30000474) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bromodomain-containing protein 8 (SMED30000474) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bromodomain-containing protein 8 (SMED30000474) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000474

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30000474SMESG000045604.1 SMESG000037340.1 SmedASXL_011514SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30000474SMESG000045604.1 SMESG000037340.1 SmedASXL_011514SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874])

HSP 1 Score: 99.3673 bits (246), Expect = 2.290e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874])

HSP 1 Score: 99.3673 bits (246), Expect = 2.291e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874])

HSP 1 Score: 99.3673 bits (246), Expect = 2.451e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   14 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 136
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874])

HSP 1 Score: 99.3673 bits (246), Expect = 2.468e-21
Identity = 51/119 (42.86%), Postives = 76/119 (63.87%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLD 514
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMD 135
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Match: BRD8 (bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874])

HSP 1 Score: 99.3673 bits (246), Expect = 2.533e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   13 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 135
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Fly
Match: Brd8 (gene:FBgn0039654 transcript:FBtr0085394)

HSP 1 Score: 67.781 bits (164), Expect = 1.413e-11
Identity = 46/138 (33.33%), Postives = 77/138 (55.80%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSF---GSSQRKDDKSWCSSKECAKQYSKLLDNIEKKKR-----SDNNNSTLPL-----KELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDES-VPEIW 535
            WS RE+L LASAV  +G + W ++SR +++    GSS R  D  W S K CA QY  LL+++E  KR       +   + P       EL++++LT ER  E++  +R +QE    ++  + +L+S ++ E  + ++W
Sbjct:   19 WSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPAD--WFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMW 154
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10])

HSP 1 Score: 107.071 bits (266), Expect = 4.750e-24
Identity = 54/127 (42.52%), Postives = 84/127 (66.14%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538
            WS+REKL LAS+V+ +G + W S+SR I+ F  S R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+ +I++ QEK   LK  ++ +++G +D  + E+W+
Sbjct:   10 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWA 134
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10])

HSP 1 Score: 107.071 bits (266), Expect = 5.093e-24
Identity = 54/127 (42.52%), Postives = 84/127 (66.14%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538
            WS+REKL LAS+V+ +G + W S+SR I+ F  S R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+ +I++ QEK   LK  ++ +++G +D  + E+W+
Sbjct:   10 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWA 134
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54])

HSP 1 Score: 106.301 bits (264), Expect = 7.128e-24
Identity = 62/165 (37.58%), Postives = 97/165 (58.79%), Query Frame = 2 
Query:  146 LPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634
            L   + WS+REKL LAS+V+++G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+ +I++ QEK   LK     +++G LD  + E+W          + I+ + K +  E E++ + TDA
Sbjct:   12 LGPTDPWSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKRLIKDTQEKHRKLKRESELIQAGHLDSKLEELW----------EEIVRSRKQEEEEAEVKRKATDA 164
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54])

HSP 1 Score: 106.301 bits (264), Expect = 7.631e-24
Identity = 61/161 (37.89%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  158 NEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634
            + WS+REKL LAS+V+++G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+ +I++ QEK   LK     +++G LD  + E+W            I+ + K +  E E++ + TDA
Sbjct:   16 DPWSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKRLIKDTQEKHRKLKRESELIQAGHLDSKLEELWEE----------IVRSRKQEEEEAEVKRKATDA 164
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036])

HSP 1 Score: 103.99 bits (258), Expect = 1.067e-23
Identity = 55/126 (43.65%), Postives = 80/126 (63.49%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ERIEEL+++I+  QEK   LK     ++SG LD  + ++W
Sbjct:   18 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036])

HSP 1 Score: 104.76 bits (260), Expect = 4.202e-23
Identity = 55/126 (43.65%), Postives = 80/126 (63.49%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ERIEEL+++I+  QEK   LK     ++SG LD  + ++W
Sbjct:   16 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 139
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Match: spg7 (spastic paraplegia 7 (pure and complicated autosomal recessive) [Source:Xenbase;Acc:XB-GENE-6034036])

HSP 1 Score: 83.1889 bits (204), Expect = 2.903e-16
Identity = 45/113 (39.82%), Postives = 68/113 (60.18%), Query Frame = 2 
Query:  203 IETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            + +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ERIEEL+++I+  QEK   LK     ++SG LD  + ++W
Sbjct:    1 MRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETVEDVIVRKLTAERIEELKKMIKETQEKYRKLKKEAELIQSGHLDSKLEDLW 111
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906])

HSP 1 Score: 99.3673 bits (246), Expect = 1.902e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906])

HSP 1 Score: 99.3673 bits (246), Expect = 1.903e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906])

HSP 1 Score: 99.3673 bits (246), Expect = 1.958e-21
Identity = 51/119 (42.86%), Postives = 76/119 (63.87%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLD 514
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMD 135
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Match: Brd8 (bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906])

HSP 1 Score: 98.9821 bits (245), Expect = 1.984e-21
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Match: sp|Q8R3B7|BRD8_MOUSE (Bromodomain-containing protein 8 OS=Mus musculus OX=10090 GN=Brd8 PE=1 SV=2)

HSP 1 Score: 99.3673 bits (246), Expect = 1.331e-20
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Match: sp|Q9H0E9|BRD8_HUMAN (Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2)

HSP 1 Score: 98.9821 bits (245), Expect = 1.718e-20
Identity = 52/125 (41.60%), Postives = 79/125 (63.20%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEI 532
            WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL++VI+  QE+   LK     +++G +D  + E+
Sbjct:   19 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDEL 141
[Close]
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: A0A2G8JPT2 (Putative bromodomain-containing protein 8 OS=Stichopus japonicus OX=307972 GN=BSL78_25380 PE=4 SV=1)

HSP 1 Score: 107.457 bits (267), Expect = 1.227e-22
Identity = 58/139 (41.73%), Postives = 91/139 (65.47%), Query Frame = 2 
Query:  143 KLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPL-KELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKD 550
            K P   EWS+REKL LASAV+ +G + W S+SR I+ F    R  D  W + K CA QYS +L+ ++  K+KRS +    +    +LIVKK+T +R+EEL++++ ++++K   L+D +  +ESG+LDE +PEI   +K+
Sbjct:    4 KTPPCQEWSIREKLCLASAVMRSGDQNWMSVSRAIKPFPEPGRPSD--WNTPKNCAIQYSSMLNEVDTPKRKRSGDKGDVVETPGDLIVKKMTFDRVEELKQMLADDRKKFKLLRDEIELIESGALDEKLPEILQDIKE 140
[Close]
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: S4RHS1 (Bromo domain-containing protein OS=Petromyzon marinus OX=7757 PE=4 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 3.518e-22
Identity = 63/144 (43.75%), Postives = 88/144 (61.11%), Query Frame = 2 
Query:  110 HSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            H LQ +   EE       WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IVKKLTVERIEEL + IR+ Q++   LK  L  +++G LD ++ EIW
Sbjct:    8 HKLQNVGPQEE-------WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETIEDVIVKKLTVERIEELTKSIRDIQDRYKKLKHELELVQNGQLDHNLHEIW 142
[Close]
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: W5KE27 (Uncharacterized protein OS=Astyanax mexicanus OX=7994 PE=4 SV=2)

HSP 1 Score: 106.301 bits (264), Expect = 1.250e-21
Identity = 61/159 (38.36%), Postives = 95/159 (59.75%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634
            WS+REKL LAS+V+++G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+++I++ QEK   LK     +++G LD  + E+W            I++  K +  E E++ + TDA
Sbjct:   16 WSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLECTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKKLIKDTQEKHRKLKREAELIQAGHLDSRLDELWGD----------IVQNRKQEEEEAEVKRKATDA 162
[Close]
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: T1FUX7 (Bromo domain-containing protein OS=Helobdella robusta OX=6412 GN=20212623 PE=4 SV=1)

HSP 1 Score: 109.383 bits (272), Expect = 1.780e-21
Identity = 63/150 (42.00%), Postives = 87/150 (58.00%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEI 613
            WS REKL+LASAV+ +G + W S+SR I+ F    R  D  W S   CA+QY +LLD +E  KR           ++IVKKLT ERIEEL+ +I+ + EK   LK+ L  ++SG L + + EIWS+L       Q  +E D    P +E+
Sbjct:   18 WSTREKLSLASAVMRSGDQNWVSVSRSIRPFLEPGRCSD--WFSQINCARQYEELLDKVETPKRKRGEKDVERPGDVIVKKLTAERIEELKVLIQQQAEKYRTLKNELEKIKSGQLQDQIKEIWSKLSQEKTNKQLPVEEDSVFPPYLEL 165
[Close]
BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Match: A0A2D4EXR2 (Uncharacterized protein (Fragment) OS=Micrurus corallinus OX=54390 PE=4 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 2.206e-21
Identity = 54/126 (42.86%), Postives = 81/126 (64.29%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            WS+REKL LAS+V+ +G + W S+SR I+ F  S R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV+KLT ER+EEL+++I+  QEK   LK     +++G +D  + EI+
Sbjct:   36 WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAESGRPPD--WFSQKHCASQYSELLETTETPKRKRGEKGEVVETIEDVIVRKLTAERVEELKKLIKETQEKYRQLKRDAELIQAGHIDHRLEEIY 159
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Match: si:ch211-59d17.3 (si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-54])

HSP 1 Score: 106.301 bits (264), Expect = 4.734e-25
Identity = 61/159 (38.36%), Postives = 95/159 (59.75%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWSRLKDNDEFVQFIIETDKTKLPEVEIESETTDA 634
            WS+REKL LAS+V+++G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERIEEL+++I++ QEK   LK     +++G LD  + E+W            I++  K +  E E++ + TDA
Sbjct:   16 WSIREKLCLASSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLECTEAPKRKRGEKGEVVETVEDVIVRRLTAERIEELKKLIKDTQEKHRKLKREAELIQAGHLDSRLDELWGD----------IVQNRKQEEEEAEVKRKATDA 162
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Match: brd8 (bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE-030722-10])

HSP 1 Score: 83.1889 bits (204), Expect = 1.863e-16
Identity = 42/114 (36.84%), Postives = 72/114 (63.16%), Query Frame = 2 
Query:  203 IETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIWS 538
            + +G + W S+SR I+ F  S R  D  W S K CA QYS+LL+  E  K+KR +       ++++IV++LT ERI+EL++++++ QEK   LK  ++ +++G +D  + E+W 
Sbjct:    1 MRSGDQNWVSVSRAIKPFSESGRPPD--WFSQKHCASQYSELLETTEAPKRKRGEKGEVVETIEDVIVRRLTTERIDELKKLLKDTQEKYRKLKKEVDLIQAGHMDSKLEELWG 112
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004772.1 (pep scaffold:Pmarinus_7.0:GL477964:1616:15578:1 gene:ENSPMAG00000004315.1 transcript:ENSPMAT00000004772.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 111.694 bits (278), Expect = 2.703e-26
Identity = 63/144 (43.75%), Postives = 88/144 (61.11%), Query Frame = 2 
Query:  110 HSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIE--KKKRSDNNNSTLPLKELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW 535
            H LQ +   EE       WS+REKL LAS+V+ +G + W S+SR I+ F    R  D  W S K CA QYS+LL+  E  K+KR +       ++++IVKKLTVERIEEL + IR+ Q++   LK  L  +++G LD ++ EIW
Sbjct:    8 HKLQNVGPQEE-------WSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASQYSELLETTETPKRKRGERGEVVETIEDVIVKKLTVERIEELTKSIRDIQDRYKKLKHELELVQNGQLDHNLHEIW 142
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Match: ENSORLT00000036108.1 (pep primary_assembly:ASM223467v1:10:26393229:26394899:-1 gene:ENSORLG00000025104.1 transcript:ENSORLT00000036108.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.0846 bits (157), Expect = 6.279e-13
Identity = 33/63 (52.38%), Postives = 41/63 (65.08%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKK 352
            WSVREKL LAS+V+ +G + W S+SR I+ F  S R  D  W S K CA QYS+LL+  E  K
Sbjct:   19 WSVREKLCLASSVMRSGDQNWVSVSRAIKPFAESGRPPD--WFSQKHCASQYSELLEATEAPK 79
[Close]
BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Match: ENSORLT00000031288.1 (pep primary_assembly:ASM223467v1:14:13811011:13812698:-1 gene:ENSORLG00000025967.1 transcript:ENSORLT00000031288.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.4622 bits (145), Expect = 1.923e-11
Identity = 29/63 (46.03%), Postives = 41/63 (65.08%), Query Frame = 2 
Query:  164 WSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKK 352
            W+VREKL LA++V+++G + W S+SR I+ F    R  D  W S K CA +YS+LL+  E  K
Sbjct:   19 WTVREKLCLATSVMKSGDQNWVSVSRAIKPFAEPGRPPD--WFSQKHCASKYSELLETTEAPK 79
[Close]
BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Match: SMESG000045604.1 (SMESG000045604.1)

HSP 1 Score: 424.091 bits (1089), Expect = 7.331e-147
Identity = 236/244 (96.72%), Postives = 240/244 (98.36%), Query Frame = 2 
Query:  545 KDNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYVSSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKXXXXXXXXXXXXXXXXXXXXKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLECLYETDD 1276
            K+NDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIY+SSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLE + +  D
Sbjct:   87 KNNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYISSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLEVIIDLFD 330

HSP 2 Score: 179.489 bits (454), Expect = 7.005e-52
Identity = 87/87 (100.00%), Postives = 87/87 (100.00%), Query Frame = 2 
Query:   86 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 346
            MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK
Sbjct:    1 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 87
[Close]
BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Match: SMESG000037340.1 (SMESG000037340.1)

HSP 1 Score: 422.935 bits (1086), Expect = 2.252e-146
Identity = 235/244 (96.31%), Postives = 240/244 (98.36%), Query Frame = 2 
Query:  545 KDNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYVSSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKXXXXXXXXXXXXXXXXXXXXKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLECLYETDD 1276
            K+NDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIEL+DEIEAKSPKIESDKESNNSCETEPAIY+SSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLE + +  D
Sbjct:   87 KNNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDKPRLLLHLKKTQKRLNEKIELNDEIEAKSPKIESDKESNNSCETEPAIYISSLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMIINNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIPEEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLEVIIDLFD 330

HSP 2 Score: 179.874 bits (455), Expect = 5.742e-52
Identity = 87/87 (100.00%), Postives = 87/87 (100.00%), Query Frame = 2 
Query:   86 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 346
            MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK
Sbjct:    1 MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSISRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEK 87
The following BLAST results are available for this feature:
BLAST of Bromodomain-containing protein 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BRD82.290e-2141.60bromodomain containing 8 [Source:HGNC Symbol;Acc:H... [more]
BRD82.291e-2141.60bromodomain containing 8 [Source:HGNC Symbol;Acc:H... [more]
BRD82.451e-2141.60bromodomain containing 8 [Source:HGNC Symbol;Acc:H... [more]
BRD82.468e-2142.86bromodomain containing 8 [Source:HGNC Symbol;Acc:H... [more]
BRD82.533e-2141.60bromodomain containing 8 [Source:HGNC Symbol;Acc:H... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Brd81.413e-1133.33gene:FBgn0039654 transcript:FBtr0085394[more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
brd84.750e-2442.52bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE... [more]
brd85.093e-2442.52bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE... [more]
si:ch211-59d17.37.128e-2437.58si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-... [more]
si:ch211-59d17.37.631e-2437.89si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
spg71.067e-2343.65spastic paraplegia 7 (pure and complicated autosom... [more]
spg74.202e-2343.65spastic paraplegia 7 (pure and complicated autosom... [more]
spg72.903e-1639.82spastic paraplegia 7 (pure and complicated autosom... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Brd81.902e-2141.60bromodomain containing 8 [Source:MGI Symbol;Acc:MG... [more]
Brd81.903e-2141.60bromodomain containing 8 [Source:MGI Symbol;Acc:MG... [more]
Brd81.958e-2142.86bromodomain containing 8 [Source:MGI Symbol;Acc:MG... [more]
Brd81.984e-2141.60bromodomain containing 8 [Source:MGI Symbol;Acc:MG... [more]
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BLAST of Bromodomain-containing protein 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q8R3B7|BRD8_MOUSE1.331e-2041.60Bromodomain-containing protein 8 OS=Mus musculus O... [more]
sp|Q9H0E9|BRD8_HUMAN1.718e-2041.60Bromodomain-containing protein 8 OS=Homo sapiens O... [more]
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BLAST of Bromodomain-containing protein 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2G8JPT21.227e-2241.73Putative bromodomain-containing protein 8 OS=Stich... [more]
S4RHS13.518e-2243.75Bromo domain-containing protein OS=Petromyzon mari... [more]
W5KE271.250e-2138.36Uncharacterized protein OS=Astyanax mexicanus OX=7... [more]
T1FUX71.780e-2142.00Bromo domain-containing protein OS=Helobdella robu... [more]
A0A2D4EXR22.206e-2142.86Uncharacterized protein (Fragment) OS=Micrurus cor... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:ch211-59d17.34.734e-2538.36si:ch211-59d17.3 [Source:ZFIN;Acc:ZDB-GENE-091113-... [more]
brd81.863e-1636.84bromodomain containing 8 [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000004772.12.703e-2643.75pep scaffold:Pmarinus_7.0:GL477964:1616:15578:1 ge... [more]
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bromodomain-containing protein 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSORLT00000036108.16.279e-1352.38pep primary_assembly:ASM223467v1:10:26393229:26394... [more]
ENSORLT00000031288.11.923e-1146.03pep primary_assembly:ASM223467v1:14:13811011:13812... [more]
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BLAST of Bromodomain-containing protein 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000045604.17.331e-14796.72SMESG000045604.1[more]
SMESG000037340.12.252e-14696.31SMESG000037340.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000474 ID=SMED30000474|Name=Bromodomain-containing protein 8|organism=Schmidtea mediterranea sexual|type=transcript|length=1472bp
TTTGTTTTAAAACTTTCTTAATGAATATTTAATTTTCAAAATAGAATTAG
ATTTTATTGTAATTTTTAAAGCTTTATATGTACAAATGACACTTAGTAAA
GAAATAACACATTCTTTACAATACCTGTCTAAATCAGAAGAAAAATTGCC
TGACAAAAATGAATGGTCTGTTAGAGAAAAACTAGCTTTAGCTAGTGCTG
TAATAGAAACAGGTCAAGAGTATTGGCCATCCATTAGTCGTTTGATCCAG
TCATTCGGATCTAGTCAACGAAAAGATGATAAATCATGGTGCTCGTCAAA
AGAATGCGCTAAACAATATTCTAAGCTTCTTGATAACATAGAAAAAAAAA
AACGTTCTGATAATAATAATTCTACACTACCTTTAAAAGAATTAATTGTT
AAAAAATTAACAGTTGAAAGAATTGAGGAGTTACAAGAAGTAATACGCAA
TGAACAAGAAAAACAATCAGCCTTAAAGGACTTATTAAATAACTTGGAAT
CTGGAAGTTTGGATGAGTCAGTACCAGAAATATGGAGCCGATTGAAAGAC
AATGATGAGTTTGTTCAATTTATCATCGAAACTGACAAAACAAAATTACC
GGAAGTGGAAATTGAATCGGAAACAACTGATGCGATGACATCGAGCTGTG
CCGAAGATGAAACCAATTCCGAAAGTGATGATAAACCTCGTTTGTTGCTT
CATTTGAAAAAAACTCAGAAAAGGTTAAACGAAAAAATTGAACTTGACGA
TGAAATCGAAGCCAAATCTCCGAAAATTGAATCCGACAAGGAATCGAACA
ACTCCTGTGAAACGGAACCGGCGATTTATGTATCAAGTTTGTCATCTAAC
CAATCTCCAGCGTCAGTACACGAAGAAATCTTTCGGGAAAAATCGACGAT
TCCGGTATCTAATTATAATAAAAAATCAGAAGAAAATTTAAATTCCTCAA
TCAATTCTCCTTGGATGAAAAAATCTAAAATGATTATCAATAATGTAATA
GATGATCCAAATTGTCATCTTTTCGATAGCATTGCACTAGTGAAAAAGGA
CAATAACTATCAAAACATCATAAAACAGATTATCAATCTTATTGATATTC
GAAATAAACTTCGTGATAATCTTTACCTCATACCGGAAGAATTTGAACAT
GACCTTTTGCTAGTGCTATGCAATGCGGCCGTGTATTACCCACTTGGTTC
ACCGTCCAATAAAATTGTGCGGAACATTTACGACACGATCTCTCCTTTGC
TCGAGTGCTTGTATGAAACAGACGATGACAGTTTGTCATCAGCGGAACCC
ATGTCAAGGCGGAGGACGAGAAAATTTGTTTCATATAATTGAAATCATTT
TAATTTGAAATGCATTTATGCTATTTTCTTTTTCAATTGTGATTATTTGT
ATATTGAAATGTATTTTAAAAGCAAGTGCTATTGTGTAATTTAACTGAAA
TAAAAATTTGTTATTAAAAAAA
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protein sequence of SMED30000474-orf-1

>SMED30000474-orf-1 ID=SMED30000474-orf-1|Name=SMED30000474-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=419bp
MTLSKEITHSLQYLSKSEEKLPDKNEWSVREKLALASAVIETGQEYWPSI
SRLIQSFGSSQRKDDKSWCSSKECAKQYSKLLDNIEKKKRSDNNNSTLPL
KELIVKKLTVERIEELQEVIRNEQEKQSALKDLLNNLESGSLDESVPEIW
SRLKDNDEFVQFIIETDKTKLPEVEIESETTDAMTSSCAEDETNSESDDK
PRLLLHLKKTQKRLNEKIELDDEIEAKSPKIESDKESNNSCETEPAIYVS
SLSSNQSPASVHEEIFREKSTIPVSNYNKKSEENLNSSINSPWMKKSKMI
INNVIDDPNCHLFDSIALVKKDNNYQNIIKQIINLIDIRNKLRDNLYLIP
EEFEHDLLLVLCNAAVYYPLGSPSNKIVRNIYDTISPLLECLYETDDDSL
SSAEPMSRRRTRKFVSYN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036427Bromodomain-like_sf
IPR001487Bromodomain
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0004887thyroid hormone receptor activity
Vocabulary: cellular component
TermDefinition
GO:0000812Swr1 complex
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005739mitochondrion
GO:0035267NuA4 histone acetyltransferase complex
Vocabulary: biological process
TermDefinition
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006357regulation of transcription from RNA polymerase II promoter
GO:0007165signal transduction
GO:0007166cell surface receptor signaling pathway
GO:0016569covalent chromatin modification
GO:0030522intracellular receptor signaling pathway
GO:0040008regulation of growth
GO:0043967histone H4 acetylation
GO:0043968histone H2A acetylation
GO:0045944positive regulation of transcription from RNA polymerase II promoter
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 75..95
NoneNo IPR availableCOILSCoilCoilcoord: 106..140
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 176..201
NoneNo IPR availablePANTHERPTHR15398BROMODOMAIN-CONTAINING PROTEIN 8coord: 20..245
coord: 177..375
NoneNo IPR availableCDDcd04369Bromodomaincoord: 293..389
e-value: 2.85585E-9
score: 51.9894
IPR001487BromodomainSMARTSM00297bromo_6coord: 286..394
e-value: 0.0039
score: 13.9
IPR001487BromodomainPFAMPF00439Bromodomaincoord: 300..376
e-value: 3.2E-8
score: 33.5
IPR001487BromodomainPROSITEPS50014BROMODOMAIN_2coord: 324..375
score: 9.49
IPR036427Bromodomain-like superfamilyGENE3DG3DSA:1.20.920.10coord: 260..399
e-value: 3.7E-11
score: 44.7
IPR036427Bromodomain-like superfamilySUPERFAMILYSSF47370Bromodomaincoord: 273..395