Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30000325
Length (bp)1263
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30000325) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30000325) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000325

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30000325SMESG000019347.1 SMESG000019346.1 dd_Smed_v4_6756_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000325SMESG000019347.1 SMESG000019346.1 dd_Smed_v4_6756_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30000325SMESG000019347.1 SMESG000019346.1 dd_Smed_v4_6756_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30000325SMESG000019346.1 Contig8101newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30000325SMESG000019346.1 Contig8101uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 131.339 bits (329), Expect = 1.303e-33
Identity = 96/345 (27.83%), Postives = 163/345 (47.25%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFY 1105
            M ++Y  + AN +   F ++L  KW GS+ KL++ E I +   Y A++++Y   L   ++R FE    Y ++    I V+F+L  +++LV  R+ N F  LPW  +   L+ +     D   RL RRT+ RY+ ++ ++ F  +S  + ++FP M  +V+ G++ + E++    +   H   +VP  W   + +KA  E  I       +++ E++ Y+     LF  D +   LVY QVVTL+VY +   C+I  Q + D   G   H    Y                    K+A  ++NP G DD+DF        N +   +  D  H    +P  K + Y
Sbjct:    1 MTVTYSSKVANATFFGFHRLLL-KWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFL-DPTKGYAGHDLDLYIPIFTLLQFFFYAGWL----KVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMS--LPKMKKDIY 337
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 127.872 bits (320), Expect = 2.340e-31
Identity = 96/345 (27.83%), Postives = 163/345 (47.25%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFY 1105
            M ++Y  + AN +   F ++L  KW GS+ KL++ E I +   Y A++++Y   L   ++R FE    Y ++    I V+F+L  +++LV  R+ N F  LPW  +   L+ +     D   RL RRT+ RY+ ++ ++ F  +S  + ++FP M  +V+ G++ + E++    +   H   +VP  W   + +KA  E  I       +++ E++ Y+     LF  D +   LVY QVVTL+VY +   C+I  Q + D   G   H    Y                    K+A  ++NP G DD+DF        N +   +  D  H    +P  K + Y
Sbjct:    1 MTVTYSSKVANATFFGFHRLLL-KWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFL-DPTKGYAGHDLDLYIPIFTLLQFFFYAGWL----KVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMS--LPKMKKDIY 337
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 126.716 bits (317), Expect = 2.378e-31
Identity = 99/375 (26.40%), Postives = 187/375 (49.87%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L   ++R FE  V Y ++  SLI VSF+L  +++LV  R+ + +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W   + ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT+++Y Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A++  L +  ++ GS ++I 
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL-DPAQGYKDHDLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQ-PSFQGSTFDIT 368
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 126.716 bits (317), Expect = 2.378e-31
Identity = 99/375 (26.40%), Postives = 187/375 (49.87%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L   ++R FE  V Y ++  SLI VSF+L  +++LV  R+ + +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W   + ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT+++Y Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A++  L +  ++ GS ++I 
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL-DPAQGYKDHDLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQ-PSFQGSTFDIT 368
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 126.716 bits (317), Expect = 2.378e-31
Identity = 99/375 (26.40%), Postives = 187/375 (49.87%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L   ++R FE  V Y ++  SLI VSF+L  +++LV  R+ + +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W   + ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT+++Y Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A++  L +  ++ GS ++I 
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL-DPAQGYKDHDLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAVLEKDLYWDAAEARAPYTAATVFQLRQ-PSFQGSTFDIT 368
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-24 (Bestrophin homolog 24 [Source:UniProtKB/Swiss-Prot;Acc:P34672])

HSP 1 Score: 133.265 bits (334), Expect = 1.278e-33
Identity = 98/342 (28.65%), Postives = 173/342 (50.58%), Query Frame = 2 
Query:   89 YREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQ-RLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNK 1111
            Y  A + S  + L  L  KW GS+ K V +E+  ++  Y  ++VIY  ALN  +QRTFE  V Y +  +S I ++FML  F++ V  R+  Y  Q+     +  L+   +      Q R+ RR I RY  ++ ++ F  IS + R++FP + ++V  G++  HEK + + I   ++  +VP  WA ++  +A K+ +IES    V +  EI  ++  +  +   D +   ++Y Q+V L+V+ Y +VC++A Q V  +    +     Y   +     I  +       K+A +MLNP G DD+DF    +   N     +  D  + + P  + +D+F+++
Sbjct:    5 YNLAVSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWT-YLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWM----KVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAP-DLKRDDFWDE 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-20 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q965X4])

HSP 1 Score: 130.183 bits (326), Expect = 4.932e-33
Identity = 101/348 (29.02%), Postives = 184/348 (52.87%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFAL-NSQRQRTFENFVAYVNKNI-SLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ--NVPDDEIGR-QAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNF 1102
            M +SY  + ++ SST FL++L  +W GS+ K V  E++ +   Y+ +A++Y   L  +    +F +   Y  K + + I ++FML  F+S++ +R+   F+ + W   S   +     S+    RL RR I RYL+++ I+ F  IS ++R++FP + S+   G+L  +E++ LE I   +   +VP++WA+++ ++A  +  + S  G V++++EI  ++  + ++   D     + Y QVV  +V +Y + C+I  Q   VP+ E+   Q     + T I     +  +       K+A ++LNPLG DD+DF    +   N  TG    D   F +  P+F+D F
Sbjct:    1 MTVSYNSDVSSVSSTNFLRLLL-RWKGSIWKSVSSELMMWCFSYFLIALLYHKVLFPNDYYDSFNDVAFYCGKELHNYIPLTFMLAFFVSIIVERWRTTFTNMGWIESSALTVNAIIVSKCDEARLIRRNIIRYLVLAQILTFRDISIRVRRRFPNIDSIKKAGFLTDNEEELLEGIDLAYNKYWVPINWAISLSNQANSKGYVISAPGMVSLIQEIKTFRNGLATICNFDWCPIPIAYPQVVFFAVRIYFLFCLITRQYIRVPNKELEPVQMFIRPFITIIEFICIVGWM-------KVAEALLNPLGEDDDDFESNFLIDKNIFTGMRIVD--QFDEAPPLFEDTF 338
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-17 (Bestrophin homolog 17 [Source:UniProtKB/Swiss-Prot;Acc:Q22566])

HSP 1 Score: 129.798 bits (325), Expect = 7.089e-33
Identity = 98/370 (26.49%), Postives = 189/370 (51.08%), Query Frame = 2 
Query:   29 LCYKR*TY*I*IVTTMPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPF-VPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSH----------FKDP--VPVFKDN 1099
            LC+ +      I+  M +SY  + ++ +   FL++L  +W GS+ K V  ++  ++  YYA+   Y +A + Q Q  FE    + +  +  + ++FML  F++ V++R+ +  + +P+       +      +    RL RR I RY+++  I+ F  IS ++R++FP ++ +VD G++   E   LES+ Q  +  + VP++WA ++   A+++K+I+    F  ++  I  ++  M +L   D I   + Y QVV L+V +Y  +C+++ Q +  D   +     +   +  P +++LE +  +   K+A  +LNPLG DD+DF +  +   N   G    D +H          F DP  +P + +N
Sbjct:   14 LCFSQ------ILNEMTVSYQLDVSSGNPLLFLRLL-GRWRGSIWKSVVGDLFVWLLFYYAIYFAYRYAFSKQLQTVFEEISIHTDDRMKYLPLTFMLGFFVTTVFERWRSALNVMPFIESVALSVAVLLPGKGREDRLTRRAIIRYVVLHQILVFRDISMRVRRRFPTLKYVVDAGFMRQEELDVLESVNQESSQTYWVPINWANSLALVAHQQKLIDQPTAFNNVIFAIKEFRVAMETLIKFDAIPIPIAYPQVVFLAVRVYFAICLVSRQFLISDMKSK-----TQMDWPVPIMTVLEFIFVIGWMKVAEVLLNPLGEDDDDFEVNSIIDNNISRGMAIVDTTHGYHPDLVDDVFSDPNYLPAYSEN 371
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-21 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q9NA59])

HSP 1 Score: 127.102 bits (318), Expect = 1.840e-32
Identity = 99/344 (28.78%), Postives = 183/344 (53.20%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKA-YKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ---NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFK 1093
            M ++Y +E ++ +S  F+K+L T W GS+ K V  E+  ++  +  V ++Y + +   +Q+ FE    ++N  +  I ++FML  F+++V  R+ + F+ + +       +GT  +  D   ++ RRTI RYL++S ++    IS ++R++FP M+SLV  G+L+  E +++      +   ++P  WA  +V KA ++ K ++S     +++  I  +++ M  L   D +   + Y QVV L+V +Y ++C+++ Q   + P  E          A  I P ++IL+ + F+   K+A ++LNPLG DD+DF    +   N  TG    D  H  D  P  K
Sbjct:    1 MTVNYNQEVSSVNSFTFVKLLMT-WRGSIWKSVRWELTMWVIAFAVVQMVYRYLMTEDQQKFFEYSAIHLNVRLIHIPLTFMLGFFVTIVVDRWRSVFTNIGFIENVALSVGTLVAGTDHAAKVLRRTIIRYLVLSQVLVLRDISMRVRRRFPTMESLVSGGFLYRDELERMYKCDTMYNKYWLPTHWANQLVHKAMFETKNVDSVQSMNSVLMNIKEFRQSMEMLTKYDWVPIPIAYPQVVFLAVRVYFIICLVSRQYLLSAPPTE----------AQSIVPIMTILQFVFFVGWMKVAEALLNPLGEDDDDFECNWLIDRNMSTGIEIVDTCH--DSCPPLK 331
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-7 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q18303])

HSP 1 Score: 128.642 bits (322), Expect = 2.359e-32
Identity = 99/357 (27.73%), Postives = 187/357 (52.38%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKAS 1144
            M  +Y+ + A       LK++F KW GS+ K +++++I +  CY  ++VIY +AL+  +Q TFE F+ + N+ +  I ++FML  F++ V  R++  F+ L            + S  D   R+ RR+I R  ++S  + F  I   +R++FP ++++V  G + S E +K   +   +A  ++  +W   ++++A +E  IES      I +EI  ++  +  ++  D +   L+Y Q+V ++++ Y +VC+++ Q V    I   A  ++      PF++I+E + ++   K+AM +LNP G D++DF    +   N        D SH   P+ + KD F+N     L  + A+
Sbjct:    1 MTYNYHYDLATSQRKVILKLIF-KWKGSLWKAIYLDLIVWCFCYAFISVIYRYALDRSQQDTFERFMQFCNRRLDYIPINFMLGFFVTTVINRWMTQFANLGMIDNIALFTSMYLSGNDERGRILRRSIVRMCVMSQTMVFRDIHIGVRKRFPTLETMVAAGIMTSSELKKYNEVESRYAKYWLGFNWTFNLLNEARREGRIESAYTQNAIAEEIRTFRSGLSLIWTYDWVPIPLMYPQLVFMAIHCYYLVCLVSRQFV----INSDAVNTTEIDLGVPFMTIIEFIFYMGWLKVAMDLLNPFGEDEDDFDCNFLIDRNLTVAMGIVDDSHDDGPI-LEKDMFWNDTVSPLYSSAAA 351
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 154.066 bits (388), Expect = 1.303e-40
Identity = 105/351 (29.91%), Postives = 190/351 (54.13%), Query Frame = 2 
Query:   74 MPISYYREAANPSS-TYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHP---FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKM 1114
            M I+Y  E A       FLK+L  +W GS+ KLV+++++ ++  YYA+ ++Y F LN  ++ TFE  V Y +    LI +SF+L  ++S+V  R+ N ++ +PW       + ++   QD   R+ RRTI RY+ +   +  + +S +++++FP + +LV+ G L  +EK  +E++ +    P   ++P+ WA +I+++A KE  I       TI+ E++ ++ +   L   D I+  LVY QVVTL+VY Y + C +  Q      +G   + +    + P F ++        L K+A S++NP G DD+DF +  +   N +   +  D  H   P  + KD +++++
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLL-RWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWL-KVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWDEV 348
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 154.451 bits (389), Expect = 1.315e-40
Identity = 105/351 (29.91%), Postives = 190/351 (54.13%), Query Frame = 2 
Query:   74 MPISYYREAANPSS-TYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHP---FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKM 1114
            M I+Y  E A       FLK+L  +W GS+ KLV+++++ ++  YYA+ ++Y F LN  ++ TFE  V Y +    LI +SF+L  ++S+V  R+ N ++ +PW       + ++   QD   R+ RRTI RY+ +   +  + +S +++++FP + +LV+ G L  +EK  +E++ +    P   ++P+ WA +I+++A KE  I       TI+ E++ ++ +   L   D I+  LVY QVVTL+VY Y + C +  Q      +G   + +    + P F ++        L K+A S++NP G DD+DF +  +   N +   +  D  H   P  + KD +++++
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLL-RWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWL-KVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWDEV 348
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 153.68 bits (387), Expect = 2.253e-40
Identity = 105/351 (29.91%), Postives = 190/351 (54.13%), Query Frame = 2 
Query:   74 MPISYYREAANPSS-TYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHP---FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKM 1114
            M I+Y  E A       FLK+L  +W GS+ KLV+++++ ++  YYA+ ++Y F LN  ++ TFE  V Y +    LI +SF+L  ++S+V  R+ N ++ +PW       + ++   QD   R+ RRTI RY+ +   +  + +S +++++FP + +LV+ G L  +EK  +E++ +    P   ++P+ WA +I+++A KE  I       TI+ E++ ++ +   L   D I+  LVY QVVTL+VY Y + C +  Q      +G   + +    + P F ++        L K+A S++NP G DD+DF +  +   N +   +  D  H   P  + KD +++++
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLL-RWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWL-KVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWDEV 348
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023)

HSP 1 Score: 153.68 bits (387), Expect = 2.311e-40
Identity = 105/351 (29.91%), Postives = 190/351 (54.13%), Query Frame = 2 
Query:   74 MPISYYREAANPSS-TYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHP---FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKM 1114
            M I+Y  E A       FLK+L  +W GS+ KLV+++++ ++  YYA+ ++Y F LN  ++ TFE  V Y +    LI +SF+L  ++S+V  R+ N ++ +PW       + ++   QD   R+ RRTI RY+ +   +  + +S +++++FP + +LV+ G L  +EK  +E++ +    P   ++P+ WA +I+++A KE  I       TI+ E++ ++ +   L   D I+  LVY QVVTL+VY Y + C +  Q      +G   + +    + P F ++        L K+A S++NP G DD+DF +  +   N +   +  D  H   P  + KD +++++
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLL-RWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWL-KVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPE-LLKDQYWDEV 348
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best4 (gene:FBgn0036491 transcript:FBtr0113172)

HSP 1 Score: 137.887 bits (346), Expect = 1.391e-35
Identity = 99/369 (26.83%), Postives = 191/369 (51.76%), Query Frame = 2 
Query:  134 LFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQ-YHAHP--FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ---NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKM---TVILSQTKASLITLSKCGTYLGSQWNINQKYRT 1213
            L  +W GS+ KL+++++I +   Y  +A+ Y   +N + +R FE  ++Y  KN SLI +SF+L  F+ +V  R+ + ++ +PW      L+ T     D   R+ RRTI RY+ +  +I F+ IS +++++FP    +++ G+L  +EK+ +E++ Q + ++P  ++P+ WA +IV +A +E  I       TI+ E++  +     L   D I+  LVY QVVT++ Y + +  ++  Q   +  D++  R   +    T +  F  +  L       K+A +++NP G DD+DF +  +   N        D  H + P  + KD ++ ++    +  +Q K      +    Y+ SQ  + +++ +
Sbjct:   21 LLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSDEDGTRIRRWFPILTVLQFFFYMGWL-------KVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHP-ELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQKRHES 381
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 135.576 bits (340), Expect = 4.396e-34
Identity = 101/376 (26.86%), Postives = 187/376 (49.73%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVP-VFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y R  A+     F ++L  +W GS+ KL++ E++ +   Y  +++ Y   L  +++R FE    Y ++   LI VSF+L  +++LV  R+   F  +PW  +   L+  H    D   RL RR++ RY  +S I+ +  +S  + ++FP M  LV  G + + E ++L+ +   H   +VP  W +++  +A  E  I +      I+ E++  + + + L+  D I+  LVY QVVT++VY + + C+I  Q + D   G   H   +   +   +     + +L   K+A  ++NP G DD+DF    +   N +   +  D     D VP V +D ++++       T AS     +  +++GS  +I+
Sbjct:    1 MTVTYSRRVADARLGTFYRLLL-RWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEGARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFL-DPAQGYPGHNLDFYLPVFTLLQFFFYVGWL---KVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVD--EMYDLVPLVERDKYWDEAEPQPPYTAAS--AEHRKPSFMGSALDIS 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 129.413 bits (324), Expect = 6.928e-33
Identity = 103/378 (27.25%), Postives = 186/378 (49.21%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNI--FLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y    AN     F K+L   W GS+ K+++ E + + A Y A+++ Y F L   ++R FE    Y +   SLI +SF+L +  +++LV  R+ + ++ +P   +   +L       D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K ES+   +   ++P  W   + + A  E  I+  N +  +++E++N++ K   LF  D I+  LVY QVVTL+VY + +VC+I  Q + D   G   H    Y                    K+A  ++NP G DD+DF    +   N +   +  D  +   P+ + +D ++N        T A+L  L K  ++ GS +++ 
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFL-DPGQGYPGHDLDLYVPIFTLLQFFFYAGWL----KVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPM-MERDRYWNDSNPRPPYTAATLFVLRK-PSFQGSTFDMT 370
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 127.487 bits (319), Expect = 1.127e-32
Identity = 93/344 (27.03%), Postives = 167/344 (48.55%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFY 1105
            M +SY  + AN     F K+LF +W GS+ KL++ E + +   Y  ++++Y   LN+ +Q  F     + NK   LI +SF+L  +++  +QR+   ++  P       ++  +    D   RL RRT+ RY  +S ++    IS ++R++F  ++ +V+ G++ + E +KL  +       ++PL+W   + S+A KE  ++       ++ E++NY+ K   LF  D I+  LVY QVVT++VY +    +I  Q V       + H   Y                    K+   ++NP G DD+DF   ++   N +   +  D  H   P P+ KD ++
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLF-RWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFV--KPASSEEHLDLYIPIFTLLEFFFYAGWL----KVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLP-PLEKDKYW 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 124.02 bits (310), Expect = 9.710e-32
Identity = 88/325 (27.08%), Postives = 159/325 (48.92%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRI 1048
            M +SY  + AN     F K+LF +W GS+ KL++ E + +   Y  ++++Y   LN+ +Q  F     + NK   LI +SF+L  +++  +QR+   ++  P       ++  +    D   RL RRT+ RY  +S ++    IS ++R++F  ++ +V+ G++ + E +KL  +       ++PL+W   + S+A KE  ++       ++ E++NY+ K   LF  D I+  LVY QVVT++VY +    +I  Q V       + H   Y                    K+   ++NP G DD+DF   ++   N +  R+
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLF-RWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVK--PASSEEHLDLYIPIFTLLEFFFYAGWL----KVGELIINPFGEDDDDFETNQLIDRNIQVCRL 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 85.1149 bits (209), Expect = 1.629e-18
Identity = 57/208 (27.40%), Postives = 107/208 (51.44%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGF 697
            M ++Y    AN     F K+L   W GS+ K+++ E + + A Y A+++ Y F L   ++R FE    Y +   SLI +SF+L  +++LV  R+ + ++ +P   +   +L       D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K ES+   +   ++P  W   + + A  E  I+  N +
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTY 207
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 133.265 bits (334), Expect = 1.675e-34
Identity = 102/374 (27.27%), Postives = 186/374 (49.73%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    A+     F ++L  +W GS+ KL++ E + +I+CY+ ++V Y F LN Q++  FE    Y +    LI VSF+L  +++LV  R+   +  +PW  +   L+ ++    D   R+ RRT+ RY  ++ ++    +S  +  +FP +Q +V+ G++   E+ K + +   H   +VP  W   +   A  E  I        I+KE+++ + +   L+  D I+  LVY QVVT++VY + + C+I  Q + D + G   H       +   +       +L   K+A  ++NP G DD+DF    +   N +   +  D  H +D  P+ KD ++N        T +++ T  +  +Y GS ++I
Sbjct:    1 MTVTYSNRVADARLGTFSRLLL-RWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL-DPQKGYPGHDMDLYVPVFTLLQFFFYAGWL---KVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMH-QDVPPLEKDIYWNDSDPQPPYTASTVET--RRPSYQGSAFDI 366
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 132.88 bits (333), Expect = 2.424e-34
Identity = 96/346 (27.75%), Postives = 173/346 (50.00%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNK 1111
            M ++Y    A+     F ++L  +W GS+ KL++ E + +I+CY+ ++V Y F LN Q++  FE    Y +    LI VSF+L  +++LV  R+   +  +PW  +   L+ ++    D   R+ RRT+ RY  ++ ++    +S  +  +FP +Q +V+ G++   E+ K + +   H   +VP  W   +   A  E  I        I+KE+++ + +   L+  D I+  LVY QVVT++VY + + C+I  Q + D + G   H       +   +       +L   K+A  ++NP G DD+DF    +   N +   +  D  H +D  P+ KD ++N 
Sbjct:    1 MTVTYSNRVADARLGTFSRLLL-RWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL-DPQKGYPGHDMDLYVPVFTLLQFFFYAGWL---KVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMH-QDVPPLEKDIYWND 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 134.035 bits (336), Expect = 2.488e-34
Identity = 103/380 (27.11%), Postives = 190/380 (50.00%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQKYRT 1213
            M ++Y    A+     F ++L  +W GS+ KL++ E + +I+CY+ ++V Y F LN Q++  FE    Y +    LI VSF+L  +++LV  R+   +  +PW  +   L+ ++    D   R+ RRT+ RY  ++ ++    +S  +  +FP +Q +V+ G++   E+ K + +   H   +VP  W   +   A  E  I        I+KE+++ + +   L+  D I+  LVY QVVT++VY + + C+I  Q + D + G   H       +   +       +L   K+A  ++NP G DD+DF    +   N +   +  D  H +D  P+ KD ++N        T +++ T  +  +Y GS ++I+  ++T
Sbjct:    1 MTVTYSNRVADARLGTFSRLLL-RWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL-DPQKGYPGHDMDLYVPVFTLLQFFFYAGWL---KVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMH-QDVPPLEKDIYWNDSDPQPPYTASTVET--RRPSYQGSAFDISFHHQT 372
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 132.88 bits (333), Expect = 5.003e-34
Identity = 96/346 (27.75%), Postives = 173/346 (50.00%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNK 1111
            M ++Y    A+     F ++L  +W GS+ KL++ E + +I+CY+ ++V Y F LN Q++  FE    Y +    LI VSF+L  +++LV  R+   +  +PW  +   L+ ++    D   R+ RRT+ RY  ++ ++    +S  +  +FP +Q +V+ G++   E+ K + +   H   +VP  W   +   A  E  I        I+KE+++ + +   L+  D I+  LVY QVVT++VY + + C+I  Q + D + G   H       +   +       +L   K+A  ++NP G DD+DF    +   N +   +  D  H +D  P+ KD ++N 
Sbjct:    1 MTVTYSNRVADARLGTFSRLLL-RWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL-DPQKGYPGHDMDLYVPVFTLLQFFFYAGWL---KVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMH-QDVPPLEKDIYWND 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: ifitm3 (interferon induced transmembrane protein 3 [Source:Xenbase;Acc:XB-GENE-5852510])

HSP 1 Score: 135.576 bits (340), Expect = 5.272e-34
Identity = 107/371 (28.84%), Postives = 187/371 (50.40%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKC-GTYLGS 1183
            M ++Y  + AN +   F ++L  KW GS+ KL++ E + + + Y  ++VIY F L   ++R FE    Y +K    I V+F+L  +++LV  R+ N F  LPW  +   L+ ++   +D + RL RRT+ RY+ ++ ++ F  +S  + ++FP M  +V+ G++ S E++  +S+   H   +VP+ W   + SKA  E  I        ++ E++ ++     LF  D +   LVY QVVTL+VY +   CII  Q +      +QA+         P  ++L+   +    K+A  ++NP G DD+DF        N +   +  D  H   P  + +D ++N   V   +   +L     C  ++LGS
Sbjct:    1 MTVTYSSKVANATFFGFHRLLL-KWRGSIYKLLYREFLLFTSLYTTLSVIYRFFLTDSQKRYFEKVSMYCDKYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSNVHGRDEYGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTSDERKLFDSLKSPHLKYWVPVIWFGNLASKARSEGRIRDSIDLQMMMNEMNKFRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLD----PKQAYPGHDLDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLMAVDEMHMNLPK-MNRDIYWNDSDV---RPPYTLAAADYCIPSFLGS 362
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 132.88 bits (333), Expect = 3.282e-34
Identity = 108/379 (28.50%), Postives = 188/379 (49.60%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ--NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQK 1204
            M I+Y  + AN     F  +L   W GS+ KL++ E + +I  YY++  +Y   L+S +Q  FE    Y +  I LI +SF+L  +++LV  R+ + +  LPW  +    + +    +D   RL RRT+ RY ++  ++    IS  + ++FP +  LV  G++   E ++L+ +   H   +VP  W   +  KAY    I       +++ E+   + +   L+  D I+  LVY QVVT++VY + + C+I  Q  N   D  G +         + P  +IL+ L ++   K+A  ++NP G DD+DF    +   N +   +  D  H   P P+ +D ++N+       T AS    S+  +++GS +NI+ K
Sbjct:    1 MTITYTNKVANARLGSFSSLLLC-WRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDL------VVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP-PMERDMYWNEAAPQPPYTAAS--ARSRRHSFMGSTFNISLK 369
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 131.724 bits (330), Expect = 2.770e-33
Identity = 101/374 (27.01%), Postives = 188/374 (50.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L  +++R FE  V Y ++  SLI VSF+L  +++LV  R+ N +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W  ++ ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT++VY Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A+   L +  ++ GS ++I
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL-DPAQGYKDHTLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQ-PSFQGSTFDI 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 131.724 bits (330), Expect = 2.770e-33
Identity = 101/374 (27.01%), Postives = 188/374 (50.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L  +++R FE  V Y ++  SLI VSF+L  +++LV  R+ N +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W  ++ ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT++VY Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A+   L +  ++ GS ++I
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL-DPAQGYKDHTLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQ-PSFQGSTFDI 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 131.724 bits (330), Expect = 2.770e-33
Identity = 101/374 (27.01%), Postives = 188/374 (50.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L  +++R FE  V Y ++  SLI VSF+L  +++LV  R+ N +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W  ++ ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT++VY Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A+   L +  ++ GS ++I
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL-DPAQGYKDHTLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQ-PSFQGSTFDI 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 130.954 bits (328), Expect = 8.178e-33
Identity = 108/379 (28.50%), Postives = 188/379 (49.60%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ--NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQK 1204
            M I+Y  + AN     F  +L   W GS+ KL++ E + +I  YY++  +Y   L+S +Q  FE    Y +  I LI +SF+L  +++LV  R+ + +  LPW  +    + +    +D   RL RRT+ RY ++  ++    IS  + ++FP +  LV  G++   E ++L+ +   H   +VP  W   +  KAY    I       +++ E+   + +   L+  D I+  LVY QVVT++VY + + C+I  Q  N   D  G +         + P  +IL+ L ++   K+A  ++NP G DD+DF    +   N +   +  D  H   P P+ +D ++N+       T AS    S+  +++GS +NI+ K
Sbjct:    1 MTITYTNKVANARLGSFSSLLLC-WRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDL------VVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP-PMERDMYWNEAAPQPPYTAAS--ARSRRHSFMGSTFNISLK 369
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 1.294e-32
Identity = 101/374 (27.01%), Postives = 188/374 (50.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F ++L   W GS+ KL++ E++ ++  Y A++  Y F L  +++R FE  V Y ++  SLI VSF+L  +++LV  R+ N +  +P       ++      +D   RL RRT+ RY  +S ++    +S  + ++FP +  +V+ G++   E++K E++   +   +VP  W  ++ ++A +E  I   +    +++E++ ++ K   LF  D I+  LVY QVVT++VY Y + C+I  Q + D   G + H       I   +       +L   K+A  ++NP G DD+DF    +   N +   +  D   + D   + KD +++        T A+   L +  ++ GS ++I
Sbjct:    1 MTVTYTARVANARFGGFSQLLLL-WRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL-DPAQGYKDHTLDLCVPIFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVD-EMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQ-PSFQGSTFDI 367
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|P34672|BST24_CAEEL (Bestrophin homolog 24 OS=Caenorhabditis elegans OX=6239 GN=best-24 PE=3 SV=1)

HSP 1 Score: 133.265 bits (334), Expect = 1.625e-32
Identity = 98/342 (28.65%), Postives = 173/342 (50.58%), Query Frame = 2 
Query:   89 YREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQ-RLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNK 1111
            Y  A + S  + L  L  KW GS+ K V +E+  ++  Y  ++VIY  ALN  +QRTFE  V Y +  +S I ++FML  F++ V  R+  Y  Q+     +  L+   +      Q R+ RR I RY  ++ ++ F  IS + R++FP + ++V  G++  HEK + + I   ++  +VP  WA ++  +A K+ +IES    V +  EI  ++  +  +   D +   ++Y Q+V L+V+ Y +VC++A Q V  +    +     Y   +     I  +       K+A +MLNP G DD+DF    +   N     +  D  + + P  + +D+F+++
Sbjct:    5 YNLAVSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWT-YLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWM----KVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAP-DLKRDDFWDE 340
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|O88870|BEST1_MOUSE (Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=2 SV=3)

HSP 1 Score: 130.954 bits (328), Expect = 5.720e-32
Identity = 108/379 (28.50%), Postives = 188/379 (49.60%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ--NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQK 1204
            M I+Y  + AN     F  +L   W GS+ KL++ E + +I  YY++  +Y   L+S +Q  FE    Y +  I LI +SF+L  +++LV  R+ + +  LPW  +    + +    +D   RL RRT+ RY ++  ++    IS  + ++FP +  LV  G++   E ++L+ +   H   +VP  W   +  KAY    I       +++ E+   + +   L+  D I+  LVY QVVT++VY + + C+I  Q  N   D  G +         + P  +IL+ L ++   K+A  ++NP G DD+DF    +   N +   +  D  H   P P+ +D ++N+       T AS    S+  +++GS +NI+ K
Sbjct:    1 MTITYTNKVANARLGSFSSLLLC-WRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDL------VVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP-PMERDMYWNEAAPQPPYTAAS--ARSRRHSFMGSTFNISLK 369
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q22566|BST17_CAEEL (Bestrophin homolog 17 OS=Caenorhabditis elegans OX=6239 GN=best-17 PE=3 SV=2)

HSP 1 Score: 129.798 bits (325), Expect = 9.017e-32
Identity = 98/370 (26.49%), Postives = 189/370 (51.08%), Query Frame = 2 
Query:   29 LCYKR*TY*I*IVTTMPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPF-VPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSH----------FKDP--VPVFKDN 1099
            LC+ +      I+  M +SY  + ++ +   FL++L  +W GS+ K V  ++  ++  YYA+   Y +A + Q Q  FE    + +  +  + ++FML  F++ V++R+ +  + +P+       +      +    RL RR I RY+++  I+ F  IS ++R++FP ++ +VD G++   E   LES+ Q  +  + VP++WA ++   A+++K+I+    F  ++  I  ++  M +L   D I   + Y QVV L+V +Y  +C+++ Q +  D   +     +   +  P +++LE +  +   K+A  +LNPLG DD+DF +  +   N   G    D +H          F DP  +P + +N
Sbjct:   14 LCFSQ------ILNEMTVSYQLDVSSGNPLLFLRLL-GRWRGSIWKSVVGDLFVWLLFYYAIYFAYRYAFSKQLQTVFEEISIHTDDRMKYLPLTFMLGFFVTTVFERWRSALNVMPFIESVALSVAVLLPGKGREDRLTRRAIIRYVVLHQILVFRDISMRVRRRFPTLKYVVDAGFMRQEELDVLESVNQESSQTYWVPINWANSLALVAHQQKLIDQPTAFNNVIFAIKEFRVAMETLIKFDAIPIPIAYPQVVFLAVRVYFAICLVSRQFLISDMKSK-----TQMDWPVPIMTVLEFIFVIGWMKVAEVLLNPLGEDDDDFEVNSIIDNNISRGMAIVDTTHGYHPDLVDDVFSDPNYLPAYSEN 371
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q21973|BST15_CAEEL (Bestrophin homolog 15 OS=Caenorhabditis elegans OX=6239 GN=best-15 PE=1 SV=2)

HSP 1 Score: 128.257 bits (321), Expect = 4.407e-31
Identity = 93/349 (26.65%), Postives = 175/349 (50.14%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXX--XXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHP-FVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSS--YATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFY 1105
            M ++Y  + ++ S   FL++   +W GS+ K +  E+  +I      +        +  + ++ ++NF A  ++N+  I ++FML  F++++ +R+ + F+ L W   +   +  +    D   R+ RR + RY++++ ++ F   S Q+R++FP M+S+V  G++  HEK+ L+++        FVP+ W+  ++  A  E  I +      I K I  +++ +  L   D +   L Y QVV L+V  Y  + +IA Q+V  D  G++    S  Y T       +  + +   + K+A SM+NPLG DD+DF    +   N   G    D ++ + P  V KD F+
Sbjct:    1 MTVNYNLDVSSASIFSFLRLQL-RWKGSIWKYLLKELFMFIIAFITVSSVYRSNLIIGEKTRKIWDNFAALFDQNMDFIPLTFMLGFFVTIIVRRWNDIFANLGWVENTAITVANYIRGTDDRTRMIRRNVIRYMVLAQVLVFRDCSIQVRKRFPTMESIVSAGFMLEHEKEALDNVQCGKLQKYFVPIQWSTGLLVDARAEGKIAADLLMNEIGKHIIEFRKMLALLSNYDWVPIPLAYPQVVFLAVRSYFFMALIARQSVLLD--GKEPEQPSILYPTVPFVMSILQFIFVVGWM-KVAESMINPLGEDDDDFECNYLLDRNLMIGLCIVDDNYNRTP-SVEKDAFW 344
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A5J4NVM2 (Bestrophin homolog OS=Paragonimus westermani OX=34504 GN=DEA37_0001967 PE=3 SV=1)

HSP 1 Score: 182.956 bits (463), Expect = 1.638e-48
Identity = 125/375 (33.33%), Postives = 208/375 (55.47%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M + Y +         F K+L  KW G V KL++++++G++A Y  ++ IY FAL    QR+FEN V + N   S+I V+F+L  ++ L++ RF + F  +PW  K    L  H    D   RL RRT  RY+L S I+  +RI+   +++FP  +S +  G +F+ E+ KL    Q H  PFVP+ W  +I++ A KEK I +++  V+++ E++ +++ +++LF +D +   LVY QVVTLSVY Y +  +   Q + D     + H      +  PF ++ E +I++ L K+A +++NP+G DD DF I EV  FN +T     D      P  V +D  +++  V L  T+ S   +S+   + GS +++ 
Sbjct:    1 MTVQYNQLVLTGGPGVFFKLLL-KWRGCVFKLIYVDVLGFLAAYGVISCIYRFALPENLQRSFENLVLFTNNFQSMIPVAFILGFYIQLIFSRFWHQFMIIPWGLKFAISLTAHLPGTDERPRLLRRTCMRYVLGSLILTCTRINVVAKKRFPTFESFISAG-IFTEEEIKLLEGMQLHVQPFVPIVWTTSIITLAEKEKFITNQHALVSLITEVNRFRQGLLNLFFMDYVCVPLVYTQVVTLSVYSYFIASLFGKQYLMDSSPLSKQH--DLKDWYFPFFTLTEFVIYVGLLKVAETLVNPMGEDDEDFDINEVIDFNWKTTWCIVDGMKTSPPA-VVRDAHWHQSVVELPHTEESRKLISR--PFRGSVYDLE 368
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A0R3UIX4 (Bestrophin homolog OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS7414 PE=3 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 8.514e-48
Identity = 118/380 (31.05%), Postives = 200/380 (52.63%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWN-AKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPD----DEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M + Y ++        FL++L  +W G V+KL++++ I ++  Y  V+ +Y FAL +++Q+ FE+ V YV     +I +SF+L  ++ LV+ RF  +F+ +PW    +  ++G      +   R  RRT  RY+  S IIA SR+    +++FP  Q LV  G L   E   ++S     A PF+PL W  AI  +A K+ +I++ +  V +++ ++N++  ++ LF++D++   LVY QVVTL+VY Y +  II  Q + D        R+ ++  + T +   + +  L       K+A +++NP+G DD DF I  +   N   G    D  H   P  + +D F++   VIL  T  S   LS   T  GS +N+ 
Sbjct:    1 MTVQYNQDVLTGGPVVFLRLLL-RWKGCVVKLIYVDFIVFMLAYAIVSCVYRFALTAEQQKNFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQHFNSVPWVFTPTLAVIGA--IQGEGRARTIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTDPVSAQPFLPLVWTTAIAMRAEKDGLIQNPHALVNLIQVVNNFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFILDSSEYSSPFRKDYYVPFYTILEFIVYMGWL-------KVAETLVNPMGEDDEDFDINNIIDSNWSYGMHMVDKKH--HPTELVRDKFWDSSNVILPHTAGSKKLLSTQMT--GSMYNLE 366
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4S2LQZ2 (Bestrophin homolog OS=Opisthorchis felineus OX=147828 GN=CRM22_005782 PE=3 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 1.019e-47
Identity = 114/368 (30.98%), Postives = 197/368 (53.53%), Query Frame = 2 
Query:  134 LFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ----NVP--DDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGT--YLGSQWNINQKYRT 1213
            LF +W G V KL++++II ++  Y+ +++IY FAL    QR FE  V +++   S+I VSF+L  ++SL++ RF + +  +PW  K    L TH       QR+ RR   RYLL S I+ F+R++  ++++FP  ++ +  G     E Q LE + Q H  PF P+ WA+++++ A KE++I + +  V ++++++++++ ++++F +D +   LVY QVVTLSVY Y++  +I  Q    N P  D+   +  +F  +                    K+A ++LNP+G DD D  +  +   N  T     D      P  V +D  + +  V L  T+ S     K G+  Y GS + I+ + RT
Sbjct:   20 LFLRWRGCVFKLIYVDIIVFLTLYFTISLIYRFALPEDTQRGFERLVLFIHNFQSMIPVSFILGFYVSLIFSRFWHQYVVIPWITKLSMGLTTHLPGSGERQRMIRRACVRYLLGSLILTFTRVNLTIKKRFPDFEAFIAAGLFTDEEVQMLEGM-QIHFQPFAPVMWAVSLLTMAEKEQLITNPHALVLLIQDVNSFRQGLLNIFFMDYVCVPLVYTQVVTLSVYSYLVASLIGRQYIMNNSPLIDNTTSKDFYFPFFTLLELVIYVGWL--------KVAETLLNPMGEDDEDLDVDSIINSNWRTAWCIVDGMKTSPPA-VLRDAHWAEAIVELPHTEES----KKLGSTPYRGSVYEISAQPRT 373
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4S2KY96 (Bestrophin homolog OS=Opisthorchis felineus OX=147828 GN=CRM22_010477 PE=3 SV=1)

HSP 1 Score: 178.333 bits (451), Expect = 7.474e-47
Identity = 115/385 (29.87%), Postives = 201/385 (52.21%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPD-----DEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQKYRT 1213
            M + Y +         FL++L  KW G V KL++++I+ ++  Y+++++IY FAL    QR FE+ + ++N+  ++I V+F+L  +++L++ RF + F  +PW  K    L  H    D   RL RRT  RYL+ S I+  +R++   +++FP + + V  G +F+ E+ KL    + H  PF P+ W  ++++ A KEK+I + +  V ++ E++N ++ ++++F +D +   LVY QVVTLSVY Y +  +I  Q +       D+     +F  + T                  K+A +++NP+G DD D  I EV  FN +      D      P  V +D  +N+  V L  T+ S      C    GS +++N +  T
Sbjct:    1 MTVQYSQLVLTGGPGVFLRLLL-KWRGCVFKLIYVDILVFLGLYFSISLIYRFALTEPLQRNFESLILFINRFQAMIPVAFILGFYVALIFARFWHQFMVIPWVLKIAVGLTAHLPGSDERPRLLRRTCMRYLMGSLILTCTRVNLVAKRRFPNLDAFVTAG-VFTEEETKLLDGMELHFQPFAPIIWTTSLITLAEKEKIITNEHALVFLIAEVNNLRQGLLNVFFMDYVCVPLVYTQVVTLSVYSYFIASLIGRQYIMSSSTMRDQNNHDFYFPFFTTLELIIYVGWL--------KVAETLVNPMGEDDEDIDINEVIDFNWKAAWCIVDGVKPSPPA-VVRDAHWNQTVVELPHTEES--RQLPCRPCRGSVFDLNLQSST 372
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A5K3EZP5 (Bestrophin homolog OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 176.792 bits (447), Expect = 9.676e-47
Identity = 118/380 (31.05%), Postives = 201/380 (52.89%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWN-AKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPD----DEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M + Y ++        FL++L  +W G V+KL++++ I ++  Y  V+ +Y FAL +++Q+ FE+ V YV     +I +SF+L  ++ LV+ RF  +F+ +PW    +  ++G      +   R  RRT  RY+  S IIA SR+    +++FP  Q LV  G L   E   ++S     A PF+PL W  AI  +A K+ +I++ +  V +++ ++N++  ++ LF++D++   LVY QVVTL+VY Y +  II  Q + D        R+ ++  + T +   + +  L       K+A +++NP+G DD DF I  +   N   G    D  H   P  + +D F++   VIL  T  S   LS   T  GS +N++
Sbjct:    1 MTVQYNQDVLTGGPVVFLRLLL-RWKGCVVKLIYVDFIVFMLAYAIVSCVYRFALTAEQQKNFESVVLYVFDFQQMIPISFILGFYVQLVFSRFWQHFNSVPWVFTPTLAVIGA--IQGEGRARTIRRTCVRYMNASLIIASSRLHVAAKKRFPTTQHLVQAGILTQREGDLIDSTDPVSAQPFLPLVWTTAIAMRAEKDGLIQNPHALVNLIQVVNNFRESLLRLFLMDKVCVPLVYTQVVTLAVYSYFLSSIIGRQFILDSSEYSSPFRKDYYVPFYTILEFIVYMGWL-------KVAETLVNPMGEDDEDFDINNIIDSNWSYGMHMVDKKHH--PTELVRDKFWDSSNVILPHTAGSKKLLSTQMT--GSMYNLD 366
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 139.428 bits (350), Expect = 2.095e-35
Identity = 105/376 (27.93%), Postives = 191/376 (50.80%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVP-VFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y R  A+     F  +L  +W GS+ KL++ E++ +   Y  ++V+Y F L+++++R FE    Y ++   LI VSF+L  +++LV  R+   F  +PW  +   L+G +    D   RL RR++ RY  +S ++ +  IS  + ++FP ++ LV  G +   E+++L+ +   H   +VP  W + +  +A  E  I +      I+ E++  + + + L+  D I+  LVY QVVT++VY + + C+I  Q + D   G   H   +   +   +     + +L   K+A  ++NP G DD+DF    +   N +   +  D     D VP V +D ++N+       T AS     K  +Y+GS  +I+
Sbjct:    1 MTVTYSRRVADARLGTFSHLLL-RWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFL-DPTQGYSGHDLDFYLPVFTLLQFFFYVGWL---KVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVD--EMYDLVPLVERDKYWNESEPQPPYTAAS--AEHKKPSYMGSALDIS 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 128.257 bits (321), Expect = 1.079e-31
Identity = 102/374 (27.27%), Postives = 188/374 (50.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F K+L   W GS+ K+++ E++ +   Y A+++ Y F L  +++R FE    Y N   SLI +SF+L  +++L+  R+ + ++ +P       +L       D   RL RRT+ RY  ++ ++    +S  + ++FP M  +V+ G++   E++K ES+   +   ++P  W   + + A  E  I+  N +  +++E++ ++ K   LF  D I+  LVY QVVTL+VY + +VC+I  Q +       QA+         P  ++L+   +    K+A  ++NP G DD+DF    +   N +   +  D   F D   + +D ++N        T A+L  L K  ++ GS +++
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDERGRLLRRTLMRYASLASLLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPS----QAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVD-EMFGDLPMMERDRYWNDSNPRPPYTAATLFVLRKP-SFQGSTFDM 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 122.094 bits (305), Expect = 8.774e-31
Identity = 98/347 (28.24%), Postives = 166/347 (47.84%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYV-QVVTLSVYMYVMVCIIAYQNV-PDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYN 1108
            M +SY  E AN     F K+LF +W GS+ KL++ E + +   Y   ++IY   L   +Q  FE    + NK   LI +SF+L  +++  +QR+   ++  P       ++  +    D   RL RRT+ RY  +S ++    IS ++ ++FP +Q +VD  ++   E + L+ +       ++PL+W   + SKA +E  ++       ++ E++NY+ K   LF  D I+  LVY  QVVTL+VY +   C+I  Q V P+     + H   Y                    K+   ++NP G DD+DF   ++   N +   +  D  H   P P+ KD ++ 
Sbjct:    1 MTVSYTLEVANARFAGFTKLLF-RWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTDGQQELFERAARHCNKFAKLIPMSFVL-FYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGSDERGRLLRRTLMRYANLSSVLILRSISTRVHKRFPTLQHIVD-AFMTEEEMRTLDHLYSDFNKYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVHVDLYVPVFTLLEFFFYAGWL----KVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLP-PLEKDKYWT 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 110.153 bits (274), Expect = 1.526e-25
Identity = 97/376 (25.80%), Postives = 176/376 (46.81%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVP-VFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y R  A+     F  +L  +W GS+ KL++ E++ +   Y  ++V+Y F L+++++R FE    Y ++   LI VSF+L  +++LV  R+   F  +PW  +   L+G +    D   RL RR++ RY  +S ++ +  IS  + ++FP ++ LV  G +   E+++L+ +   H   +VP  W + +  +A  E  I +      I+                           VVT++VY + + C+I  Q + D   G   H   +   +   +     + +L   K+A  ++NP G DD+DF    +   N +   +  D     D VP V +D ++N+       T AS     K  +Y+GS  +I+
Sbjct:    1 MTVTYSRRVADARLGTFSHLLL-RWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILN--------------------------VVTVAVYSFFLACLIGRQFL-DPTQGYSGHDLDFYLPVFTLLQFFFYVGWL---KVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVD--EMYDLVPLVERDKYWNESEPQPPYTAAS--AEHKKPSYMGSALDIS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 66.6254 bits (161), Expect = 1.370e-11
Identity = 54/197 (27.41%), Postives = 85/197 (43.15%), Query Frame = 2 
Query:  557 GYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKAS 1144
            G++   EK+  E++   H   ++P  W   + SKA K+  I+      TI+ E++ ++    +LF  D +   LVY QVVTL+VY +    II  Q + D   G   H    Y                    K+A  ++NP G DD+DF        N +   +  D  H   P  + KD ++N   V    T+A+
Sbjct:   83 GFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFL-DPAQGYPGHDLDLYVPVFTLLQFFFYSGWL----KVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVDEMHMNIPR-MTKDVYWNDPDVRPPYTRAA 273
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 144.821 bits (364), Expect = 7.313e-40
Identity = 96/359 (26.74%), Postives = 180/359 (50.14%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLI 1150
            M ++Y  + AN     F ++L  +W GS+ KL++ E   ++  ++ ++ +Y + L   ++R FE    Y NK   LI VSF+L  +++LV  R+ + +  LPW  +  HL+  +    D   RL RRT+ RY  +S ++    +S  + ++FP M  +V+ G++   E++K + +   H   +VP  W   + ++A  E  I        I+ +++N++     L+  D ++  LVY QVVT++VY + + C+I  Q      +G Q +         P  ++L+   +    K+A  ++NP G DD+DF        N +   +  D   ++D  P+  D +++ ++     T ASL+
Sbjct:    1 MTVTYSNKVANARLGGFSQLLL-RWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVHGADERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTPAERRKFDGLRSPHNKFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQF-----LGPQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQVSLMGVD-EMYRDLPPLEHDVYWDDISPCPPYTGASLV 352
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 120.168 bits (300), Expect = 5.657e-30
Identity = 96/375 (25.60%), Postives = 180/375 (48.00%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNIN 1198
            M ++Y    AN     F K+L  +W GS+ KL++ E   Y   Y A+++   FAL+  ++R FE    Y N   +LI V      +++LV  R+ + ++ +P   +    +       D   RL RRT+ RY  +S ++    +S  + ++FP M  +V+ G++   E+++ + +   +   +VP  W  ++ ++A  E  +        ++ E++ Y+     LF  D I+  LVY QVVT++VY + + C+I  Q + D   G   H       +   +       +L   K+A  ++NP G DD+DF    +   N +   +  D  +   P+ + +D ++N        T A++ TL K  ++LGS ++++
Sbjct:    1 MTVTYTNRVANARLCGFSKLLL-QWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGVDERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTRDERKRFDGLRCSYNKYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL-DPAQGYPGHDMDLYIPVFTLLQFFFYAGWL---KVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLPL-LQRDMYWNASDPRPPYTAATMSTLHK-PSFLGSAFDMS 368
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 140.198 bits (352), Expect = 8.038e-36
Identity = 97/346 (28.03%), Postives = 173/346 (50.00%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYN 1108
            M ++Y  + AN +   F ++L  +W GS+ KL++ E + +   Y  +++IY  AL+ Q++R FE    Y ++    I V+F+L  +++LV  R+ N F  LPW  +    + +    +D + RL RRT+ RY+ ++ ++ F  +S  + ++FP +  +V+ G++   E++  E+I   H   ++P+ W   + S+A +E  I+       I+ E++ ++    +LF  D +   LVY QVVTL+VY +   CII  Q + D   G   H    Y                    K+A  ++NP G DD+DF    +   N +   +  D  H   P  + KD ++N
Sbjct:    1 MTVTYSSKVANATFLSFHRLLL-RWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDEYGRLLRRTLVRYINLTSLLIFRSVSTAVCKRFPTIDHVVEAGFMTPEERKVFENIRSPHLKYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFL-DPAQGHPGHDLDLYVPVFTLLQFFFYSGWL----KVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVDEMHMNLPH-MTKDIYWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 131.724 bits (330), Expect = 4.386e-33
Identity = 101/375 (26.93%), Postives = 181/375 (48.27%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAH-FSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNI 1195
            M ++Y    AN     F K+L   W GS+ K+++ E + +   Y A+++ Y F L   ++R FE    Y N   SLI +SF+L  +++L+  R+ N ++ +P   +   +L       D   RL RR++ RY  +S ++    +S  + ++FP M  +V+ G++   E++K E +   +   ++P  W   + + A  E  I   +    +++E++ ++ K   LF  D ++  LVY QVVTL+VY + +VC+I  Q + D   G Q H    Y                    K+A  ++NP G DD+DF    +   N +   +  D  +   PV + +D ++N        T A+L  L K  ++ GS +++
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDERGRLLRRSMMRYASLSALLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFEGLHSPYNKYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFL-DPSQGYQGHDLDLYVPIFTLLQFFFYAGWL----KVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPV-MERDRYWNDSNPRPPYTAATLFGLRK-PSFQGSTFDM 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 124.79 bits (312), Expect = 1.612e-30
Identity = 107/377 (28.38%), Postives = 184/377 (48.81%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQK 1204
            M ++Y R  A+     F  +L  +W GS+ KL++ E+I +   YY ++++Y    N QR R FE    Y ++   LI VSF+L  +++LV  R+   F  +PW  +   L+G H    D   RL RR + RY+ +S ++ +  +S  + ++FP  + LV Q  + S E +  E +   H   +VP  W + +  +A  E  I +      I+ E+++ + K + L+  D I+  LVY QV T++VY + + C+I  Q + D   G   H   +   +   +     + +L   K+A  ++NP G DD+DF    V   N +   +  D  +   P+ V KD ++N        T AS     +  +++GS  +I  K
Sbjct:    1 MTVTYSRRVADAGLGTFFHLLL-RWKGSIYKLLYRELIIFTLLYYFLSLVYYMLDNDQR-RLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGHVRGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRFPTTEHLV-QALMTSEELRHFEELPSPHNKFWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFL-DPAQGYPGHDVDFYLPVFTLLQFFFYVGWL---KVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLPL-VEKDVYWNDSEPQPPYTAAS--AEHRKPSFMGSALDIVPK 366
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000019346.1 (SMESG000019346.1)

HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0
Identity = 323/380 (85.00%), Postives = 335/380 (88.16%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQKYRT 1213
            MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEIIGYIACYYAVAVIYTFALNSQRQRTFENFVAYVNKNISLIK+     +F ++  +  +   S   WN+                  +Q R++ +       I  +RISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATFIPPFISILELLIFLSLNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQKYRT
Sbjct:    1 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEIIGYIACYYAVAVIYTFALNSQRQRTFENFVAYVNKNISLIKIC---KLFFTITMECQI---STSSWNS-----------------LVQSRSLSK-------ITKTRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATFIPPFISILELLIFLSLNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVILSQTKASLITLSKCGTYLGSQWNINQKYRT 350
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030918.1 (SMESG000030918.1)

HSP 1 Score: 196.052 bits (497), Expect = 5.822e-57
Identity = 120/360 (33.33%), Postives = 203/360 (56.39%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQ--------------RLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNK 1111
            M + YY+E  +     FLK+L  KW G V KL++++ I + + Y  ++ IY   L  + +R FE  V+YV ++ SLI V+F+L  ++SLV+ RF  +F+ +PW  K   ++ +H ++  P                RLQRR+I RYL  S II  SR+S  ++++FP +  + ++G L  HE + +++   +   PF+P++W+  IV KA  +  I +    +  VKEI+ +++ +  LF+LD++   LVY QVVTL+VY Y + C+I  Q + D       +  +   F+ P  +IL+ ++++   KLA++++NP+G DD DF +  V  +N E G    D      P P+ KD F++K
Sbjct:    1 MTVQYYQEVLSAGPVAFLKLL-RKWKGGVFKLIYMDFIVFSSLYTMISCIYRLILRDEHKRQFEKVVSYVYQSQSLIPVAFILGFYVSLVFNRFWRHFNTVPWITKIAIMIASHMNTVSPANSGDDESIRKDKEEARLQRRSIIRYLTASLIITLSRVSVPVKRRFPNIDEIFNKGILLEHEAEIIKNTEPFTMQPFLPITWSATIVMKAGTQGRITNEAVLINTVKEINKFRQLLQELFLLDQVCVPLVYTQVVTLAVYSYFLSCLIGRQFIMD-----SVNVETTQDFVVPIFTILQFIVYMGWLKLALTLVNPMGEDDEDFDLNCVVDYNFEIGLAIADGVKIDQP-PLIKDKFFDK 353
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000030927.1 (SMESG000030927.1)

HSP 1 Score: 160.229 bits (404), Expect = 4.114e-44
Identity = 109/361 (30.19%), Postives = 199/361 (55.12%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDP----------------FQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQ-NVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFY 1105
            M + YY++        FLK+L  +W GS+ +L++ +++ + A Y A+++I+ F L    +R FE  + YV K+ +LI V+F++  +++L++ RF  +F+ +PW +K+  L+ T +  QDP                  RLQ+RTI RYL+ S +I  SR+S  ++++F  +  L ++G L  HE   +E    Y   PF+P+              +I + +  + IV+EI+ +++ +  LF+LD+I   LVY QVVTL++Y Y + C++  Q  +  D +  +  F      + P  +IL+ ++++   KLA+S++NP+G DD DF +  +  +N +TG   +   + K   P F+ +F+
Sbjct:    1 MTVKYYQDVLTAGPIGFLKLLI-RWKGSIFRLIYSDLLLFAAFYMAISMIHRFMLPEDNKRQFETVINYVAKSQALIPVAFIVGFYVNLIFSRFWQHFNTIPWISKTALLVSTFF--QDPEFNPEMSEDEIKKEKEKTRLQKRTIIRYLVSSLLITLSRVSIPVKRRFKNINELSNKGILLEHESGLIEKCEPYIMQPFLPV--------------IIPNESLLIGIVEEINKFRQLLQELFLLDQICVPLVYTQVVTLAIYSYFLSCLVGRQFIIVSDYLKNRNDF------VIPIFTILQFIVYIGWIKLALSLVNPMGEDDEDFDLNTLIDYNFQTG--ISSVENLKSSQPPFEKDFF 336
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000054993.1 (SMESG000054993.1)

HSP 1 Score: 152.91 bits (385), Expect = 7.164e-42
Identity = 118/387 (30.49%), Postives = 194/387 (50.13%), Query Frame = 2 
Query:   74 MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEXXXXXXXXXXXXXXXTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQKFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVF-KDNFY--NKMTVILSQTK--------ASLITLSKCGTYLGSQWNINQ 1201
            M I+Y    A      FL++L  +W GS+ K+++ E+I +   Y  ++ +Y F L    ++ FE F A+  KN  +I V F+L  +++LV  R+ N F ++PW       + T     D    + RRTI RYL +SF + F+ IS + ++ FP +++L++ G L   E++ L      +A  FVP  WA  +V +A  EKM     G  T+++EI  ++  +  ++  D IN  LVY Q+ T+SV+ Y M+ + A Q +  D++        +  F+     +          K+A S++NP G DD+DF I E+   N +   +  D  H  D  P   KD F+  N+   I+   K         SL+ L+   ++LGS+ NI Q
Sbjct:    1 MTITYINTVATSKYWTFLRLLL-RWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWL----------KVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMH--DSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGSKINIFQ 374
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000023666.1 (SMESG000023666.1)

HSP 1 Score: 135.961 bits (341), Expect = 2.413e-36
Identity = 90/294 (30.61%), Postives = 147/294 (50.00%), Query Frame = 2 
Query:  230 FALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQLPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQK-FPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEKMIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVMVCIIAYQNVPDDEIGRQAHFSSYATXXXXXXXXXXXXXXXXXNKLAMSMLNPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYN 1108
            FALN   +  F + V  V    S I ++ +L  F+  VY  F+  F  +PW  K   LL  H  S    + + R  I RYL  + I+   R+    R K F  + SLV +G L S E   + +I   H HP +P+SW++++V  A  E+++ + +GFV IV+ I+ Y+R +  + + D++++ L+Y QV TL+VY Y M  + A Q+   + +       S   F+     +          K A+ +LNP+G D+ +F I EV  +N   G   ++      P  +F+D F+N
Sbjct:   19 FALNGNYKIIFMDIVKTVFDYQSKIPMAIILGFFIVSVYANFIRRFKMIPWIMKIITLLSFHLHSTSKRETILRSHIIRYLNTALIMTIIRVH---RHKLFVDIASLVKRGVLTSKEADMINAIPYLHIHPLIPISWSISLVVSARNEELLTNTHGFVFIVEAINEYKRNLFEIILNDQVSFPLIYTQVNTLAVYAYFMFSLFASQDTLYNGMDMYIPVRSIVEFLVYMGLL----------KCAIGLLNPMGNDEENFEIDEVILYNWMIGHCISNEVVDTAPEQLFQDLFFN 299
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST31.303e-3327.83bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST32.340e-3127.83bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST22.378e-3126.40bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST22.378e-3126.40bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST22.378e-3126.40bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-241.278e-3328.65Bestrophin homolog 24 [Source:UniProtKB/Swiss-Pro... [more]
best-204.932e-3329.02Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q... [more]
best-177.089e-3326.49Bestrophin homolog 17 [Source:UniProtKB/Swiss-Pro... [more]
best-211.840e-3228.78Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q... [more]
best-72.359e-3227.73Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best11.303e-4029.91gene:FBgn0040238 transcript:FBtr0082183[more]
Best11.315e-4029.91gene:FBgn0040238 transcript:FBtr0337020[more]
Best12.253e-4029.91gene:FBgn0040238 transcript:FBtr0114590[more]
Best12.311e-4029.91gene:FBgn0040238 transcript:FBtr0306023[more]
Best41.391e-3526.83gene:FBgn0036491 transcript:FBtr0113172[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best14.396e-3426.86bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best26.928e-3327.25bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best41.127e-3227.03bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best49.710e-3227.08bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best21.629e-1827.40bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best11.675e-3427.27bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best12.424e-3427.75bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best12.488e-3427.11bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best15.003e-3427.75bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
ifitm35.272e-3428.84interferon induced transmembrane protein 3 [Source... [more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best13.282e-3428.50bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best22.770e-3327.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best22.770e-3327.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best22.770e-3327.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best18.178e-3328.50bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BGM5|BEST2_MOUSE1.294e-3227.01Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=... [more]
sp|P34672|BST24_CAEEL1.625e-3228.65Bestrophin homolog 24 OS=Caenorhabditis elegans OX... [more]
sp|O88870|BEST1_MOUSE5.720e-3228.50Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=... [more]
sp|Q22566|BST17_CAEEL9.017e-3226.49Bestrophin homolog 17 OS=Caenorhabditis elegans OX... [more]
sp|Q21973|BST15_CAEEL4.407e-3126.65Bestrophin homolog 15 OS=Caenorhabditis elegans OX... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NVM21.638e-4833.33Bestrophin homolog OS=Paragonimus westermani OX=34... [more]
A0A0R3UIX48.514e-4831.05Bestrophin homolog OS=Mesocestoides corti OX=53468... [more]
A0A4S2LQZ21.019e-4730.98Bestrophin homolog OS=Opisthorchis felineus OX=147... [more]
A0A4S2KY967.474e-4729.87Bestrophin homolog OS=Opisthorchis felineus OX=147... [more]
A0A5K3EZP59.676e-4731.05Bestrophin homolog OS=Mesocestoides corti OX=53468... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best12.095e-3527.93bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best21.079e-3127.27bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best48.774e-3128.24bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best11.526e-2525.80bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST31.370e-1127.41bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best17.313e-4026.74bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best25.657e-3025.60bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
BEST38.038e-3628.03bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
best24.386e-3326.93bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
best11.612e-3028.38bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019346.10.000e+085.00SMESG000019346.1[more]
SMESG000030918.15.822e-5733.33SMESG000030918.1[more]
SMESG000030927.14.114e-4430.19SMESG000030927.1[more]
SMESG000054993.17.164e-4230.49SMESG000054993.1[more]
SMESG000023666.12.413e-3630.61SMESG000023666.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000325 ID=SMED30000325|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1263bp
CGCATTTATATTTACAATCAAATATAAATTATGTTATAAACGATAAACAT
ATTGAATATAAATTGTGACCACAATGCCAATATCTTATTATCGCGAAGCA
GCTAATCCCTCTTCAACATATTTTCTAAAGATTCTTTTCACTAAATGGGA
CGGAAGCGTTATGAAATTAGTTTTCATTGAGATAATCGGTTACATCGCCT
GCTATTATGCCGTTGCGGTGATTTACACGTTTGCACTCAACAGTCAACGG
CAAAGAACTTTTGAAAACTTTGTTGCTTATGTCAACAAAAACATCTCATT
AATCAAAGTATCCTTCATGCTAAACATTTTCCTTTCTTTGGTTTACCAAA
GATTTGTAAATTATTTTTCACAATTACCATGGAATGCCAAATCTCAACAT
CTTCTTGGAACTCACTGGTCCAGTCAAGATCCCTTTCAAAGATTACAAAG
ACGTACAATTTGTCGATATCTTTTGGTTTCTTTCATAATTGCCTTTAGTC
GAATAAGTTTTCAAATGAGACAAAAATTTCCCAAAATGCAATCACTAGTG
GACCAAGGATATCTATTTTCTCATGAAAAACAAAAACTTGAAAGCATTAC
ACAGTACCATGCTCATCCTTTTGTGCCTCTCAGTTGGGCATTGGCTATTG
TTAGCAAAGCATACAAGGAGAAAATGATTGAATCCAGGAATGGATTTGTG
ACAATAGTTAAAGAAATATCAAATTATCAACGAAAAATGGTCTCATTGTT
CATCCTTGACAGAATCAACTATTCTTTAGTCTATGTTCAAGTTGTCACGT
TGTCAGTTTACATGTACGTCATGGTCTGCATTATCGCCTACCAGAATGTA
CCAGATGACGAGATAGGTCGGCAAGCGCATTTCTCGTCATATGCAACCTT
TATTCCACCATTTATCAGCATTCTTGAATTGCTGATATTTCTTTCATTGA
ACAAGTTGGCAATGAGCATGCTGAACCCCCTTGGGATTGATGACAATGAC
TTTCATATTTTTGAAGTTTTCAAGTTTAACCAAGAAACTGGGAGAATATT
TACTGATTGGTCACATTTTAAAGATCCAGTTCCAGTTTTTAAAGATAATT
TCTACAACAAAATGACTGTTATTCTATCTCAGACAAAAGCTTCATTAATT
ACTTTAAGCAAATGCGGCACTTATTTGGGGTCCCAGTGGAATATCAATCA
AAAGTACAGAACCAAGAAAAAAAGTGAAAAGAATTGTTGTAGCTCCTAGG
AAAACGAAAATTT
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protein sequence of SMED30000325-orf-1

>SMED30000325-orf-1 ID=SMED30000325-orf-1|Name=SMED30000325-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=392bp
MPISYYREAANPSSTYFLKILFTKWDGSVMKLVFIEIIGYIACYYAVAVI
YTFALNSQRQRTFENFVAYVNKNISLIKVSFMLNIFLSLVYQRFVNYFSQ
LPWNAKSQHLLGTHWSSQDPFQRLQRRTICRYLLVSFIIAFSRISFQMRQ
KFPKMQSLVDQGYLFSHEKQKLESITQYHAHPFVPLSWALAIVSKAYKEK
MIESRNGFVTIVKEISNYQRKMVSLFILDRINYSLVYVQVVTLSVYMYVM
VCIIAYQNVPDDEIGRQAHFSSYATFIPPFISILELLIFLSLNKLAMSML
NPLGIDDNDFHIFEVFKFNQETGRIFTDWSHFKDPVPVFKDNFYNKMTVI
LSQTKASLITLSKCGTYLGSQWNINQKYRTKKKSEKNCCSS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 10..312
e-value: 1.7E-54
score: 185.2
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 1..374
NoneNo IPR availableTMHMMTMhelixcoord: 270..292
NoneNo IPR availableTMHMMTMhelixcoord: 129..146
NoneNo IPR availableTMHMMTMhelixcoord: 76..95
NoneNo IPR availableTMHMMTMhelixcoord: 33..55
NoneNo IPR availableTMHMMTMhelixcoord: 233..255