RING-type domain-containing protein

Overview
NameRING-type domain-containing protein
Smed IDSMED30000311
Length (bp)2087
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RING-type domain-containing protein (SMED30000311) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30000311) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30000311) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30000311) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000311

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30000311h1SMcG0021887 Contig11358uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000311h1SMcG0021887 Contig11358newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000311h1SMcG0021889 Contig11358uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000311h1SMcG0021889 Contig11358newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000311h1SMcG0021889 Contig38584newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000311h1SMcG0021889 Contig38584uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30000311h1SMcG0021889 dd_Smed_v4_6290_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30000311h1SMcG0021889 dd_Smed_v4_6290_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30000311h1SMcG0021889 dd_Smed_v4_6290_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30000311h1SMcG0021889 OX_Smed_1.0.12778ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30000311h1SMcG0021889 dd_Smed_v4_6290_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
dorsal ventral margin of the whole animalSMED30000311h1SMcG0021889 dd_Smed_v4_6290_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM5 (tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276])

HSP 1 Score: 53.9138 bits (128), Expect = 1.151e-8
Identity = 24/54 (44.44%), Postives = 35/54 (64.81%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW 487
            +++ V+CPI L +L +P+ L CGHSFC  C+    K  ML     +CPVCR+S+
Sbjct:    9 VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISY 62
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM5 (tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276])

HSP 1 Score: 55.8398 bits (133), Expect = 3.429e-8
Identity = 24/50 (48.00%), Postives = 32/50 (64.00%), Query Frame = 2 
Query:  338 VSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW 487
            V+CPI L +L +P+ L CGHSFC  C+    K  ML     +CPVCR+S+
Sbjct:   13 VTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISY 62
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM5 (tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276])

HSP 1 Score: 56.6102 bits (135), Expect = 3.905e-8
Identity = 24/50 (48.00%), Postives = 32/50 (64.00%), Query Frame = 2 
Query:  338 VSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW 487
            V+CPI L +L +P+ L CGHSFC  C+    K  ML     +CPVCR+S+
Sbjct:   13 VTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISY 62
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM5 (tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276])

HSP 1 Score: 56.9954 bits (136), Expect = 5.415e-8
Identity = 24/50 (48.00%), Postives = 32/50 (64.00%), Query Frame = 2 
Query:  338 VSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW 487
            V+CPI L +L +P+ L CGHSFC  C+    K  ML     +CPVCR+S+
Sbjct:   13 VTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISY 62
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM58 (tripartite motif containing 58 [Source:HGNC Symbol;Acc:HGNC:24150])

HSP 1 Score: 57.3806 bits (137), Expect = 5.474e-8
Identity = 26/56 (46.43%), Postives = 33/56 (58.93%), Query Frame = 2 
Query:  314 PSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECI-ERCLKTQMLQNNHFACPVCR 478
            P E L +   CP+ L  L+ P+ + CGHSFCL CI E C K+   Q   +ACP CR
Sbjct:    6 PGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCR 61
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 58.5362 bits (140), Expect = 1.664e-8
Identity = 31/98 (31.63%), Postives = 50/98 (51.02%), Query Frame = 2 
Query:  272 EEQKDFLARKNSILPS------EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E+ ++ ++R  S  P+      E +E +++CPI L   ++P  LPC H+FC  C+E C  T  L  N   CP CR    +P +G   +  +Y L   +
Sbjct:   13 EKMRELMSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADT--LHRN-LKCPECRAEHNIPYDGVKAFQPNYTLTGFL 107
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 58.151 bits (139), Expect = 1.940e-8
Identity = 31/98 (31.63%), Postives = 50/98 (51.02%), Query Frame = 2 
Query:  272 EEQKDFLARKNSILPS------EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E+ ++ ++R  S  P+      E +E +++CPI L   ++P  LPC H+FC  C+E C  T  L  N   CP CR    +P +G   +  +Y L   +
Sbjct:   13 EKMRELMSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADT--LHRN-LKCPECRAEHNIPYDGVKAFQPNYTLTGFL 107
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ftr07 (finTRIM family, member 7 [Source:ZFIN;Acc:ZDB-GENE-070912-229])

HSP 1 Score: 53.9138 bits (128), Expect = 1.434e-8
Identity = 25/60 (41.67%), Postives = 38/60 (63.33%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPLEG 505
            +D  SC + L +L+ P+ +PCGHS+C+ CI  C   Q  QN  ++CP CR ++ P P+ G
Sbjct:   10 QDQFSCSVCLDLLKDPVTIPCGHSYCMSCISDCWD-QDEQNGVYSCPHCRQTFTPRPVLG 68
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ftr50 (finTRIM family, member 50 [Source:ZFIN;Acc:ZDB-GENE-080215-17])

HSP 1 Score: 56.225 bits (134), Expect = 6.208e-8
Identity = 24/57 (42.11%), Postives = 37/57 (64.91%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVP 496
            ED  +CP+ L +L+ P+ +PCGHS+C+ CI  C   Q  Q   ++CP+C+ S+ P P
Sbjct:   10 EDQFTCPVCLDVLQDPVTIPCGHSYCMSCITDCW-NQEEQKRIYSCPLCKQSFTPRP 65
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ftr07 (finTRIM family, member 7 [Source:ZFIN;Acc:ZDB-GENE-070912-229])

HSP 1 Score: 55.0694 bits (131), Expect = 9.352e-8
Identity = 25/60 (41.67%), Postives = 38/60 (63.33%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPLEG 505
            +D  SC + L +L+ P+ +PCGHS+C+ CI  C   Q  QN  ++CP CR ++ P P+ G
Sbjct:   10 QDQFSCSVCLDLLKDPVTIPCGHSYCMSCISDCWD-QDEQNGVYSCPHCRQTFTPRPVLG 68
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ftr93 (finTRIM family, member 93 [Source:ZFIN;Acc:ZDB-GENE-131126-26])

HSP 1 Score: 55.8398 bits (133), Expect = 1.381e-7
Identity = 23/58 (39.66%), Postives = 37/58 (63.79%), Query Frame = 2 
Query:  332 DMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNH--FACPVCRVSW-PVP 496
            D  SCP+ L +++ P+ +PCGHS+C+ CI  C   + L+N    ++CP CR ++ P P
Sbjct:    9 DQFSCPVCLDVMKDPVTIPCGHSYCMSCITDCWNQEELKNTEKIYSCPQCRHTFSPRP 66
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: mid2 (midline 2 [Source:ZFIN;Acc:ZDB-GENE-090220-1])

HSP 1 Score: 55.4546 bits (132), Expect = 1.901e-7
Identity = 30/82 (36.59%), Postives = 42/82 (51.22%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIER-----CLKTQMLQN-NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R     C  T+ L++ + F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCSSTKPLESISAFQCPTCRYVITLNQRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mid1 (midline 1 [Source:NCBI gene;Acc:448651])

HSP 1 Score: 59.3066 bits (142), Expect = 1.955e-8
Identity = 31/85 (36.47%), Postives = 40/85 (47.06%), Query Frame = 2 
Query:  311 LPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            L  E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:   15 LKMETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCANNESVESINAFQCPTCRYVITLSKRGLEGLKRNVTLQNII 99
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mid1 (midline 1 [Source:NCBI gene;Acc:448651])

HSP 1 Score: 58.9214 bits (141), Expect = 2.564e-8
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCANNESVESINAFQCPTCRYVITLSKRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mid1 (midline 1 [Source:NCBI gene;Acc:448651])

HSP 1 Score: 58.5362 bits (140), Expect = 2.995e-8
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCANNESVESINAFQCPTCRYVITLSKRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mid1 (midline 1 [Source:NCBI gene;Acc:448651])

HSP 1 Score: 58.5362 bits (140), Expect = 3.240e-8
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCANNESVESINAFQCPTCRYVITLSKRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mid1 (midline 1 [Source:NCBI gene;Acc:448651])

HSP 1 Score: 58.151 bits (139), Expect = 3.543e-8
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCANNESVESINAFQCPTCRYVITLSKRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mid1 (midline 1 [Source:MGI Symbol;Acc:MGI:1100537])

HSP 1 Score: 56.225 bits (134), Expect = 1.063e-7
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mid1 (midline 1 [Source:MGI Symbol;Acc:MGI:1100537])

HSP 1 Score: 56.225 bits (134), Expect = 1.066e-7
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mid1 (midline 1 [Source:MGI Symbol;Acc:MGI:1100537])

HSP 1 Score: 56.225 bits (134), Expect = 1.066e-7
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mid1 (midline 1 [Source:MGI Symbol;Acc:MGI:1100537])

HSP 1 Score: 56.225 bits (134), Expect = 1.066e-7
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mid1 (midline 1 [Source:MGI Symbol;Acc:MGI:1100537])

HSP 1 Score: 56.225 bits (134), Expect = 1.066e-7
Identity = 30/82 (36.59%), Postives = 39/82 (47.56%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R L +    N      N F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5A1M4|TRY3_CANAL (Transcriptional regulator of yeast form adherence 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=TRY3 PE=2 SV=2)

HSP 1 Score: 52.7582 bits (125), Expect = 6.413e-8
Identity = 24/58 (41.38%), Postives = 35/58 (60.34%), Query Frame = 2 
Query:  305 SILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCR 478
            SI+   P  D  SCPI + I  +PI+L CGH FC+ C+      +M Q++  +CP+CR
Sbjct:  385 SIIKVIPQLDDYSCPICMNIAYKPIRLSCGHLFCVRCL-----VKMKQDDKTSCPLCR 437

HSP 2 Score: 27.335 bits (59), Expect = 6.413e-8
Identity = 13/38 (34.21%), Postives = 23/38 (60.53%), Query Frame = 3 
Query:  144 NFHL*ILITFCYVNSSASRRLLIRF*K*A*NGLKGDFP 257
            N+HL  ++ F  +N+ A R++L +F K    G++  FP
Sbjct:  322 NYHLLKILQFQTINNEALRKILKKFDKQTSLGIQKTFP 359
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5D7I2|TRIM5_PITPI (Tripartite motif-containing protein 5 OS=Pithecia pithecia OX=43777 GN=TRIM5 PE=3 SV=1)

HSP 1 Score: 59.3066 bits (142), Expect = 8.548e-8
Identity = 25/55 (45.45%), Postives = 35/55 (63.64%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWP 490
            +++ V+CPI L +L  P+ L CGHSFC  CI    K  ML     +CP+CR+S+P
Sbjct:    9 IKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKKSMLHQGERSCPLCRISYP 63
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03601|NHL1_CAEEL (RING finger protein nhl-1 OS=Caenorhabditis elegans OX=6239 GN=nhl-1 PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 2.467e-7
Identity = 31/98 (31.63%), Postives = 50/98 (51.02%), Query Frame = 2 
Query:  272 EEQKDFLARKNSILPS------EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E+ ++ ++R  S  P+      E +E +++CPI L   ++P  LPC H+FC  C+E C  T  L  N   CP CR    +P +G   +  +Y L   +
Sbjct:   13 EKMRELMSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADT--LHRN-LKCPECRAEHNIPYDGVKAFQPNYTLTGFL 107
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8NG06|TRI58_HUMAN (E3 ubiquitin-protein ligase TRIM58 OS=Homo sapiens OX=9606 GN=TRIM58 PE=2 SV=2)

HSP 1 Score: 57.3806 bits (137), Expect = 2.629e-7
Identity = 26/56 (46.43%), Postives = 33/56 (58.93%), Query Frame = 2 
Query:  314 PSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECI-ERCLKTQMLQNNHFACPVCR 478
            P E L +   CP+ L  L+ P+ + CGHSFCL CI E C K+   Q   +ACP CR
Sbjct:    6 PGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCR 61
[Close]
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5D7H8|TRIM5_PLEDO (Tripartite motif-containing protein 5 OS=Plecturocebus donacophilus OX=230833 GN=TRIM5 PE=3 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 5.242e-7
Identity = 24/55 (43.64%), Postives = 34/55 (61.82%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWP 490
            +++ V+CPI L +L  P+ L CGHSFC  CI    K   L     +CP+CR+S+P
Sbjct:    9 IKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESTLHQGERSCPLCRISYP 63
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A1I8IQ65 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 158.688 bits (400), Expect = 2.370e-36
Identity = 133/491 (27.09%), Postives = 217/491 (44.20%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQM---------LQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXX--XXXXXXXXXXXXXXXXXXXXXXXIIEKADIVKKLAEDIANK-KLSDGSVDKAFLIT---ELNSILK-----------KLQEPSTPVNNVENSGSRRSSFELK--------------------------IETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDEDPQFR-KLVFVNT-SHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPV-HGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            E LE++ +C IHLG L +P  LPC H FCL C+ R    Q            +   ACP+CRVS  +P +G    P + A   I  Y+ E   ++ +LS          +S R+ S+  K +I+  LA+D   + +L   + D+A L+     LN ++            KL  P+ P  N     +R+                                ++    R  M +   YK+ +       L+         +  L  DP+ +  ++ +N+ SH +++Y         F  +     ++  ++ F   LV+VSG++ S D  +     +    LDG +I   +R         P+  GF +D  +G + +AQP    +  +T  L      F F    LHP  V + +  + +W SCP+   ILI++  TG Y +  T Q+F+S PAHII+T D +I F D++  RVFWI R++E++ +QRL F
Sbjct: 1233 EQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHGSLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRLDAEDGATRGKLGNPAQP--NRRGRDARQPLLPPPPPPPSARRSSTSSRHESSEEAEEEDALDLSFIRHNMRRHSSYKLKEIETGFLDLQHPGAGLEIGAAGLIADPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPS-DSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFEN--LHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF 1718
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267ECL9 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g1 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.385e-25
Identity = 71/226 (31.42%), Postives = 116/226 (51.33%), Query Frame = 2 
Query:  953 DEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPV-HGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            D + Q   ++  + SH +++Y         F  +     ++  ++ F   LV+VSG++ S D  +     +V   LDG +I   +R         P+  GF +D  +G + +AQP    +  +T  L      F F    LHP  V + +  + +W SCP+   ILI++  TG Y +  T Q+F+S PAHII+T D +I F D++  RVFWI R++E++ +QRL F
Sbjct:  347 DPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPS-DSATRWTSAIVCVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFEN--LHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF 569

HSP 2 Score: 64.3142 bits (155), Expect = 7.406e-7
Identity = 50/161 (31.06%), Postives = 77/161 (47.83%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQML---------QNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXX--XXXXXXXXXIIEKADIVKKLAEDIANK-KLSDGSVDKAFLIT---ELNSILKKL 757
            E LE++ +C IHLG L +P  LPC H FCL C+ R    Q            +   ACP+CRVS  +P +G    P + A   I  Y+ E   ++L             +S R+ S+  K +I+  LA+D   + +L   + D+A L+     LN ++ +L
Sbjct:   70 EQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHGSLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRL 230
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267DTD7 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g2 PE=4 SV=1)

HSP 1 Score: 122.094 bits (305), Expect = 4.291e-25
Identity = 70/226 (30.97%), Postives = 115/226 (50.88%), Query Frame = 2 
Query:  953 DEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPV-HGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            D + Q   ++  + SH +++Y         F  +     ++  ++ F   LV+VSG++ S D  +     +    LDG +I   +R         P+  GF +D  +G + +AQP    +  +T  L      F F    LHP  V + +  + +W SCP+   ILI++  TG Y +  T Q+F+S PAHII+T D +I F D++  RVFWI R++E++ +QRL F
Sbjct:  347 DPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFTNGLVYVSGVVPS-DSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFEN--LHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF 569

HSP 2 Score: 64.3142 bits (155), Expect = 7.217e-7
Identity = 50/161 (31.06%), Postives = 77/161 (47.83%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQML---------QNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXX--XXXXXXXXXIIEKADIVKKLAEDIANK-KLSDGSVDKAFLIT---ELNSILKKL 757
            E LE++ +C IHLG L +P  LPC H FCL C+ R    Q            +   ACP+CRVS  +P +G    P + A   I  Y+ E   ++L             +S R+ S+  K +I+  LA+D   + +L   + D+A L+     LN ++ +L
Sbjct:   70 EQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHGSLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRL 230
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267FRC4 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g3 PE=4 SV=1)

HSP 1 Score: 121.709 bits (304), Expect = 4.488e-25
Identity = 70/226 (30.97%), Postives = 115/226 (50.88%), Query Frame = 2 
Query:  953 DEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPV-HGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            D + Q   ++  + SH +++Y         F  +     ++  ++ F   LV+VSG++ S D  +     +    LDG +I   +R         P+  GF +D  +G + +AQP    +  +T  L      F F    LHP  V + +  + +W SCP+   ILI++  TG Y +  T Q+F+S PAHII+T D +I F D++  RVFWI R++E++ +QRL F
Sbjct:  347 DPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPS-DSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFEN--LHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF 569

HSP 2 Score: 64.3142 bits (155), Expect = 7.535e-7
Identity = 33/88 (37.50%), Postives = 44/88 (50.00%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQML---------QNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYV 556
            E LE++ +C IHLG L +P  LPC H FCL C+ R    Q            +   ACP+CRVS  +P +G    P + A   I  Y+
Sbjct:   70 EQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHGSLACPLCRVSVRLPPDGVRALPTAAAHQSIADYI 157
[Close]
BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267FKZ3 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014891g1 PE=4 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 6.901e-23
Identity = 82/281 (29.18%), Postives = 132/281 (46.98%), Query Frame = 2 
Query:  845 REQMSKLCEYKVIQ------ERLSEEVLKELMKSPAKDSVDLDEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDC-----LKPVFLRFFQDLVFVSGLIYSK------DDGSVLAG---VLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDIDTQ-GNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            R  M +   YK+ +        L +    EL    A    D D      +LV +N+    ++   + E     +P+   D      L+   +R    LV+VSG+   +      D      G   V+    LDG+++   +R     +E L   GF +D++ G++ +AQP    +   T  L      F F    LHP +V + +  K +W SCPA   ILI++  TG Y +  T Q+F+S PAHII+T D +I F D++  R+FW+ R++E++ +QRL F
Sbjct:  331 RHNMKRNSSYKMKEIDMGTCAELLQSTRGELEIGAAGLLADADGSTDQAELVLLNSCSRSLLVYSSQEGQIKDLPVLIGDSNPGGRLQCHHMRLVNGLVYVSGVAQQQQQQQAADSTGAPTGWLSVVACLQLDGQVVKRIERPGGSRDEPL-FAGFFVDSRRGDMVVAQPSDQKVEFFTPCLGRTGHWFTFEN--LHPQYVTWTRERKMLWVSCPAEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRLFWVIRRSEFIFVQRLQF 608

HSP 2 Score: 66.6254 bits (161), Expect = 1.474e-7
Identity = 31/77 (40.26%), Postives = 43/77 (55.84%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYV 556
            LE++ +CPIHLG L  P  L C H FCL C+E+   +Q    + F CP+CRV   +P  G    P ++    II Y+
Sbjct:   38 LEELTTCPIHLGRLLEPKLLTCSHVFCLTCLEK-WDSQQPSRDRFPCPLCRVEARLPAGGLRCLPPAHVHQSIIKYI 113
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000043980.1 (pep primary_assembly:Astyanax_mexicanus-2.0:7:18176324:18192673:1 gene:ENSAMXG00000031445.1 transcript:ENSAMXT00000043980.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 9.093e-9
Identity = 24/57 (42.11%), Postives = 38/57 (66.67%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVP 496
            +D  SCPI L +L+ P+ +PCGHS+C+ CI+ C K     ++ ++CP CR ++ P P
Sbjct:    9 QDSFSCPICLDLLKEPVTIPCGHSYCMSCIQHCWKEDQHPDSVYSCPQCRQAFSPRP 65
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000005684.2 (tripartite motif-containing protein 16-like [Source:NCBI gene;Acc:103027621])

HSP 1 Score: 56.6102 bits (135), Expect = 4.787e-8
Identity = 26/58 (44.83%), Postives = 38/58 (65.52%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPL 499
            +D +SCPI L +L+ P+ +PCGHSFCL CI+ C      Q   ++CP CR ++ P P+
Sbjct:   11 QDSLSCPICLDLLKDPVTIPCGHSFCLGCIKDCWAGDD-QRKVYSCPQCRHTFTPRPV 67
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000041324.1 (tripartite motif-containing protein 16-like [Source:NCBI gene;Acc:103027621])

HSP 1 Score: 56.225 bits (134), Expect = 8.918e-8
Identity = 26/58 (44.83%), Postives = 38/58 (65.52%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPL 499
            +D +SCPI L +L+ P+ +PCGHSFCL CI+ C      Q   ++CP CR ++ P P+
Sbjct:    9 QDSLSCPICLDLLKDPVTIPCGHSFCLGCIKDCWAGDD-QRKVYSCPQCRHTFTPRPV 65
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000009915.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02002070.1:1154:7027:-1 gene:ENSAMXG00000009652.2 transcript:ENSAMXT00000009915.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.4546 bits (132), Expect = 1.101e-7
Identity = 27/67 (40.30%), Postives = 40/67 (59.70%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPLEGAHGWPQS 526
            +D  SCPI L +L+ P+ +PCGHSFCL CI    K    Q+  ++CP CR ++ P P+   +  P+ 
Sbjct:    9 QDSFSCPICLDLLKDPVAIPCGHSFCLGCI----KDSWDQSGIYSCPQCRHTFTPRPVLNKNTMPEG 71
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000035312.1 (pep primary_assembly:Astyanax_mexicanus-2.0:17:4121266:4123083:1 gene:ENSAMXG00000038784.1 transcript:ENSAMXT00000035312.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.8398 bits (133), Expect = 1.171e-7
Identity = 23/52 (44.23%), Postives = 34/52 (65.38%), Query Frame = 2 
Query:  332 DMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW 487
            D ++CPI L +L  P+ +PCGHSFCL+CI+ C      Q   ++CP CR ++
Sbjct:   28 DSLTCPICLDLLRDPVAIPCGHSFCLDCIKDCWHRDD-QRGVYSCPQCRHTF 78
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010730.1 (pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 gene:ENSPMAG00000009719.1 transcript:ENSPMAT00000010730.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.521 bits (114), Expect = 1.767e-7
Identity = 26/80 (32.50%), Postives = 42/80 (52.50%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN------NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            LE+ ++CP+   + E P  LPC H+FC  C+E  L+  +  +        F CP CR    +PL G    P +++L +I+
Sbjct:    4 LEEELTCPVCYSLFEDPRVLPCSHTFCRGCLEDILQGSLHLSPWRPLRTPFKCPSCRHVCELPLTGFTSLPVNFSLRNIV 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: trim59 (tripartite motif containing 59 [Source:ZFIN;Acc:ZDB-GENE-060724-2])

HSP 1 Score: 49.2914 bits (116), Expect = 1.416e-6
Identity = 27/83 (32.53%), Postives = 41/83 (49.40%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQ-------NNHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE+ ++CP+   + E P  LPC H+FC  C+E  L+  + Q            CP CR  + +P  G    P +Y+L  I+
Sbjct:    2 EHLEEDLTCPVCFSLFEEPRVLPCSHTFCRRCLESVLQATVEQFPLWRALRVPLKCPSCRHMFDMPSAGLSYLPLNYSLVAIV 84
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO32195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVR6])

HSP 1 Score: 52.7582 bits (125), Expect = 3.415e-7
Identity = 27/73 (36.99%), Postives = 39/73 (53.42%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLP-CGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYAL 535
            E ++D +SCPI     E P  LP C H+ C EC+   ++   L+   F CP+CR    VP +G  G+P +  L
Sbjct:   17 ENIQDEISCPICYEDFEEPKCLPKCAHNICRECLLGIIEKAQLE--RFECPICRAIVAVPKDGIDGFPTNSLL 87
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47729 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLP8])

HSP 1 Score: 51.9878 bits (123), Expect = 7.274e-7
Identity = 23/69 (33.33%), Postives = 38/69 (55.07%), Query Frame = 2 
Query:  344 CPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIIT 550
            C I       P  LPC HSFC  C+++ +++Q        CP C+ S PVP +G   +P ++ +N+++T
Sbjct:   17 CGICQETYNNPKVLPCLHSFCQNCLDKSIRSQ---ERVLVCPTCQCSVPVPAKGIEAFPVNFFINNMLT 82
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47716 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLM3])

HSP 1 Score: 49.6766 bits (117), Expect = 1.624e-6
Identity = 25/78 (32.05%), Postives = 40/78 (51.28%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQN--NHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYV 556
            E ++ CPI L     P  LPC H+FC  C++      M+Q+  N   CP CR    VP EG      ++ +N+++ ++
Sbjct:   11 EHLLKCPICLETYRTPKVLPCLHTFCQHCLK-----GMIQSGENIIVCPTCRCEVCVPKEGVSALSTNFFINNMLDFL 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO41278 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Y4])

HSP 1 Score: 50.0618 bits (118), Expect = 2.905e-6
Identity = 25/75 (33.33%), Postives = 38/75 (50.67%), Query Frame = 2 
Query:  326 LEDMVSCPIHLGILERPIQLP-CGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            L D  +CP+ + + E P  LP C H+ C EC+E+   T    +    CP+CR    +P  G + +P +  L  II
Sbjct:   16 LGDEGACPVCIEVFEEPKSLPSCAHNVCRECLEKI--TARNSSRFVECPICRARSEIPQNGVNSFPTNTLLVRII 88
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO29107 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4K5])

HSP 1 Score: 48.9062 bits (115), Expect = 4.380e-6
Identity = 19/37 (51.35%), Postives = 22/37 (59.46%), Query Frame = 2 
Query:  323 PLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLK 433
            PLE    CPI L  L  P+Q PCGH FC  CI R ++
Sbjct:  371 PLESKYECPICLLGLRDPVQTPCGHRFCFNCIRRSIR 407
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000019661.2 (pep primary_assembly:ASM223467v1:13:32568675:32574156:1 gene:ENSORLG00000015701.2 transcript:ENSORLT00000019661.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 1.134e-7
Identity = 22/50 (44.00%), Postives = 31/50 (62.00%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCR 478
            ED  +CP+ L +L+ P  LPCGHS+CL CI+     + L    ++CP CR
Sbjct:   18 EDSFACPVCLDVLKDPTTLPCGHSYCLSCIQSHWDKE-LSKGQYSCPQCR 66
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: mid2 (midline 2 [Source:NCBI gene;Acc:101175413])

HSP 1 Score: 55.4546 bits (132), Expect = 1.880e-7
Identity = 30/82 (36.59%), Postives = 42/82 (51.22%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIER-----CLKTQMLQN-NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R     C  T+ L++ + F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCSTTKPLESISAFQCPTCRYVITLNHRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: mid2 (midline 2 [Source:NCBI gene;Acc:101175413])

HSP 1 Score: 55.4546 bits (132), Expect = 1.940e-7
Identity = 30/82 (36.59%), Postives = 42/82 (51.22%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIER-----CLKTQMLQN-NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R     C  T+ L++ + F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCSTTKPLESISAFQCPTCRYVITLNHRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: mid2 (midline 2 [Source:NCBI gene;Acc:101175413])

HSP 1 Score: 55.0694 bits (131), Expect = 1.941e-7
Identity = 30/82 (36.59%), Postives = 42/82 (51.22%), Query Frame = 2 
Query:  320 EPLEDMVSCPIHLGILERPIQLPCGHSFCLECIER-----CLKTQMLQN-NHFACPVCRVSWPVPLEGAHGWPQSYALNDII 547
            E LE  ++CPI L + E P+ LPC HS C  C  R     C  T+ L++ + F CP CR    +   G  G  ++  L +II
Sbjct:    2 ETLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCSTTKPLESISAFQCPTCRYVITLNHRGLEGLKRNVTLQNII 83
[Close]
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000022213.2 (tripartite motif-containing protein 16-like [Source:NCBI gene;Acc:105356282])

HSP 1 Score: 55.0694 bits (131), Expect = 2.158e-7
Identity = 24/58 (41.38%), Postives = 36/58 (62.07%), Query Frame = 2 
Query:  329 EDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSW-PVPL 499
            +D   CP+ L +L  P  +PCGHS+CL+CIE    ++    +H++CP CR  + P PL
Sbjct:   10 QDQFCCPVCLEVLRDPATIPCGHSYCLDCIED-YWSKTKHRDHYSCPQCRQEFSPKPL 66
[Close]
BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000081132.1 (SMESG000081132.1)

HSP 1 Score: 1018.07 bits (2631), Expect = 0.000e+0
Identity = 520/521 (99.81%), Postives = 521/521 (100.00%), Query Frame = 2 
Query:  224 MSVKWTERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXXXXXXXXXXXIIEKADIVKKLAEDIANKKLSDGSVDKAFLITELNSILKKLQEPSTPVNNVENSGSRRSSFELKIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDIDTQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKSVFTSKPCKNTEKGPSSSSHVNCCAIM 1786
            MSVKWTERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVQEEKQKKLSGKSSQKYRNSNSNRKNSIIEKADIVKKLAEDIANKKLSDGSVDKAFLITELNSILKKLQEPSTPVNNVENSGSRRSSFELKIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDIDTQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKSVFT+KPCKNTEKGPSSSSHVNCCAIM
Sbjct:    1 MSVKWTERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVQEEKQKKLSGKSSQKYRNSNSNRKNSIIEKADIVKKLAEDIANKKLSDGSVDKAFLITELNSILKKLQEPSTPVNNVENSGSRRSSFELKIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDIDTQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKSVFTAKPCKNTEKGPSSSSHVNCCAIM 521
[Close]
BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000020467.1 (SMESG000020467.1)

HSP 1 Score: 201.445 bits (511), Expect = 2.049e-56
Identity = 148/505 (29.31%), Postives = 255/505 (50.50%), Query Frame = 2 
Query:  296 RKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXXXXXXXXXXXII----EKADIVKKLAEDIANKKLSDGSVDKAFLITELNSILKKLQEP----STP-------VNNVENSGSRRSSFELKIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDE----DPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF-GTTLKKANFSL-----LRGFCNSSALLLITDKSVFTSKPCK 1732
            ++NS +    LED++ CPIHLG++E P  LPCGH+FCL C+  CL    +  N F+CPVCR    +  +     P S A   +  Y+ E K +    +       SN +   SI     +K ++VK L  +I+    S  + +      + + ILK +  P    S P       +++V N     S++EL ++ E  RE M K  EYK++++ ++  ++     S  ++ + + +    + +   +V+ +    ++       +   F     S  +KP+FL+ + + +F+SG I +          L++ SL G++I  S  +   ++    + GF ID   G + LA PD   I ++TS+L E    + F   +LHP+F+   + T EIWASCP    I+I+D  TGSY Q GT Q++N+ P+HI  + DN++ FLD + +RVFW++++N+++ IQR+ F G   K+ N  +     + G      LL +   + +  +P K
Sbjct:   38 KRNSRMSMSKLEDLIMCPIHLGMMEDPRILPCGHAFCLNCLYSCLIRMSISVN-FSCPVCRRYCEIDQKTVCLLPPSIATKQLTDYIVETKSRLFMKQHPNMEYLSNESIIESISTTVDQKRELVKHLIREISEYTKSKSNQE------QFHEILKSIDTPLVIESQPSESENAILHSVTNMEIFNSNYEL-MDVETIRENMRKYSEYKLLRD-VNHSIVN--FHSSGRNKMIIADIKLLNHEAEVIVWTSVHGNLIAVKTPDHSVHDFTIQIDSCEVKPIFLKIYNNDLFLSGYIENSATKEK-HYYLIQSSLTGELIHTSV-FNSSHDITTKIAGFHIDPGSGKILLAIPDACKIAILTSNLVETSHGYHFT--DLHPSFITQNQDTAEIWASCPQDGRIIIIDEETGSYRQLGTDQIYNAIPSHITISGDNRVMFLDCRQNRVFWVRKRNDFILIQRINFIGHHNKQLNGKMTAMVAISGTDTLGRLLFVIGSNAYLVRPAK 527
[Close]
BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000069646.1 (SMESG000069646.1)

HSP 1 Score: 150.599 bits (379), Expect = 1.268e-38
Identity = 119/451 (26.39%), Postives = 219/451 (48.56%), Query Frame = 2 
Query:  317 SEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXXXXXXXXXXXIIEKADIVKKLAEDIA--NKKLSDGSVDKAFLITELNSILKKLQEPSTPVNNVENSGSRRSSFELKIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDS------VDLD---EDPQFRKLVFVNT-SHEIVIY-DCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVH-GFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAF 1624
            +  LE++V+C IHLGI+  P +L C H+FC  C++   K  +       CP+CRV            P +     +I+ V + +  K           S+         K D+V+ L ++I   N+       D+ F+ T      +   + +  + + +N+     ++E+ ++ E  RE M K  +Y+V++     ++ K + +   + S       D++     P+   LV V++ SH++++Y D N +T   F  +  +D +KP ++R +Q  + ++G +   D    +  + ++ S+ GK++  S+ Y   N   LP+  GFDI+  +   YL  P+  ++ + +++  E+   + F+E    P ++ F     ++W SCP ++ ILILD  +G +  F T Q+  + P  I  T D KI FLD   +R  WIKR+NEY+  Q+L F
Sbjct:   46 TRELEEIVTCCIHLGIMNDPRKLFCQHAFCYNCLKEYSKICV----DLICPICRVKEKT--NDIDKLPSALTEKQLISVVMKNRITKCIEDPQISKGLSDEI-------KEDLVQHLVKEINLNNRVYKVSKSDEVFVSTSS----QNTNQITAYLESNQNTSIDDLTYEM-MDIETIRENMLKYSQYEVVKRDGVHKICKNIHQLQKESSQFEFSIFDINISATHPKLSHLVLVDSKSHQLLVYSDSNIKT---FHIVLKNDIIKPEYIRIYQGNLILTGRL---DRNEEIGSIFLQCSMCGKILRQSELYIWPNTPDLPMMMGFDINEKEEKYYLCMPNSGSVRIYSTNFIESHQYYEFDEN--RPEYIAFSSTQNQLWISCPRNRRILILDLDSGIFRLFNTEQINKAIPKMIFVTDDEKIIFLDITGNRFIWIKRRNEYILTQKLNF 470
[Close]
BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 149.443 bits (376), Expect = 4.729e-38
Identity = 148/518 (28.57%), Postives = 238/518 (45.95%), Query Frame = 2 
Query:  239 TERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIE----RCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXXXXXXXXXXXIIEKADIVKKLAEDIANKKLSDGSVD---KAFLITELNSILKKLQEPSTPVNN--------VENSGSRRSSF-ELKIET--EVT-REQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLD-EDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKS-VFTSKP 1726
            +ER+ +KS      K F    N     E LED+++CPIHLG ++ P QL CGH FCL C+E      L+T   Q     CP+CR    +  +G      S+    +  Y+  +KQK L+  +     +  S+       K  ++ +L  DI  K LS   +        I  L  +L+K   P  P N+        V NS     S+ +LK ++  E T R+ M K  EY + +  L+      +  +    +  LD  D +   +  +  S EI + +       SF     +  + P+F++ F + +FVSG I     G   +  L++ SL+G+  + S  Y+          GF  D T  ++++A P    + ++ + L E E K VF    L P FV     T+EIW SCP    I + D +T +Y+   T Q++ S P HII T D+++ FLD   SR+FWI R N  L IQ +    + ++   + ++    S  ++L +D +  F ++P
Sbjct:   17 SERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQ---ICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNI-FKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKI-----GLDQSSCLIQLSLNGERENISPIYSGL------FGGFCFDLTNNSIFVAYPSRNQVILLDNSL-EKELK-VFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSI--SENMILFSDGNKTFIARP 515
[Close]
BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 148.673 bits (374), Expect = 7.325e-38
Identity = 148/518 (28.57%), Postives = 238/518 (45.95%), Query Frame = 2 
Query:  239 TERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIE----RCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVXXXXXXXXXXXXXXXXXXXXXXXXXXIIEKADIVKKLAEDIANKKLSDGSVD---KAFLITELNSILKKLQEPSTPVNN--------VENSGSRRSSF-ELKIET--EVT-REQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLD-EDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKS-VFTSKP 1726
            +ER+ +KS      K F    N     E LED+++CPIHLG ++ P QL CGH FCL C+E      L+T   Q     CP+CR    +  +G      S+    +  Y+  +KQK L+  +     +  S+       K  ++ +L  DI  K LS   +        I  L  +L+K   P  P N+        V NS     S+ +LK ++  E T R+ M K  EY + +  L+      +  +    +  LD  D +   +  +  S EI + +       SF     +  + P+F++ F + +FVSG I     G   +  L++ SL+G+  + S  Y+          GF  D T  ++++A P    + ++ + L E E K VF    L P FV     T+EIW SCP    I + D +T +Y+   T Q++ S P HII T D+++ FLD   SR+FWI R N  L IQ +    + ++   + ++    S  ++L +D +  F ++P
Sbjct:   26 SERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQ---ICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNI-FKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKI-----GLDQSSCLIQLSLNGERENISPIYSGL------FGGFCFDLTNNSIFVAYPSRNQVILLDNSL-EKELK-VFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSI--SENMILFSDGNKTFIARP 524
The following BLAST results are available for this feature:
BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRIM51.151e-844.44tripartite motif containing 5 [Source:HGNC Symbol;... [more]
TRIM53.429e-848.00tripartite motif containing 5 [Source:HGNC Symbol;... [more]
TRIM53.905e-848.00tripartite motif containing 5 [Source:HGNC Symbol;... [more]
TRIM55.415e-848.00tripartite motif containing 5 [Source:HGNC Symbol;... [more]
TRIM585.474e-846.43tripartite motif containing 58 [Source:HGNC Symbol... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
nhl-11.664e-831.63RING finger protein nhl-1 [Source:UniProtKB/Swiss... [more]
nhl-11.940e-831.63RING finger protein nhl-1 [Source:UniProtKB/Swiss... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ftr071.434e-841.67finTRIM family, member 7 [Source:ZFIN;Acc:ZDB-GENE... [more]
ftr506.208e-842.11finTRIM family, member 50 [Source:ZFIN;Acc:ZDB-GEN... [more]
ftr079.352e-841.67finTRIM family, member 7 [Source:ZFIN;Acc:ZDB-GENE... [more]
ftr931.381e-739.66finTRIM family, member 93 [Source:ZFIN;Acc:ZDB-GEN... [more]
mid21.901e-736.59midline 2 [Source:ZFIN;Acc:ZDB-GENE-090220-1][more]
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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mid11.955e-836.47midline 1 [Source:NCBI gene;Acc:448651][more]
mid12.564e-836.59midline 1 [Source:NCBI gene;Acc:448651][more]
mid12.995e-836.59midline 1 [Source:NCBI gene;Acc:448651][more]
mid13.240e-836.59midline 1 [Source:NCBI gene;Acc:448651][more]
mid13.543e-836.59midline 1 [Source:NCBI gene;Acc:448651][more]
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BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mid11.063e-736.59midline 1 [Source:MGI Symbol;Acc:MGI:1100537][more]
Mid11.066e-736.59midline 1 [Source:MGI Symbol;Acc:MGI:1100537][more]
Mid11.066e-736.59midline 1 [Source:MGI Symbol;Acc:MGI:1100537][more]
Mid11.066e-736.59midline 1 [Source:MGI Symbol;Acc:MGI:1100537][more]
Mid11.066e-736.59midline 1 [Source:MGI Symbol;Acc:MGI:1100537][more]
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BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5A1M4|TRY3_CANAL6.413e-841.38Transcriptional regulator of yeast form adherence ... [more]
sp|Q5D7I2|TRIM5_PITPI8.548e-845.45Tripartite motif-containing protein 5 OS=Pithecia ... [more]
sp|Q03601|NHL1_CAEEL2.467e-731.63RING finger protein nhl-1 OS=Caenorhabditis elegan... [more]
sp|Q8NG06|TRI58_HUMAN2.629e-746.43E3 ubiquitin-protein ligase TRIM58 OS=Homo sapiens... [more]
sp|Q5D7H8|TRIM5_PLEDO5.242e-743.64Tripartite motif-containing protein 5 OS=Plecturoc... [more]
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BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8IQ652.370e-3627.09RING-type domain-containing protein OS=Macrostomum... [more]
A0A267ECL91.385e-2531.42RING-type domain-containing protein OS=Macrostomum... [more]
A0A267DTD74.291e-2530.97RING-type domain-containing protein OS=Macrostomum... [more]
A0A267FRC44.488e-2530.97RING-type domain-containing protein OS=Macrostomum... [more]
A0A267FKZ36.901e-2329.18RING-type domain-containing protein OS=Macrostomum... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000043980.19.093e-942.11pep primary_assembly:Astyanax_mexicanus-2.0:7:1817... [more]
ENSAMXT00000005684.24.787e-844.83tripartite motif-containing protein 16-like [Sourc... [more]
ENSAMXT00000041324.18.918e-844.83tripartite motif-containing protein 16-like [Sourc... [more]
ENSAMXT00000009915.21.101e-740.30pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000035312.11.171e-744.23pep primary_assembly:Astyanax_mexicanus-2.0:17:412... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000010730.11.767e-732.50pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 ge... [more]
trim591.416e-632.53tripartite motif containing 59 [Source:ZFIN;Acc:ZD... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO321953.415e-736.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO477297.274e-733.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO477161.624e-632.05Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO412782.905e-633.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO291074.380e-651.35Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000019661.21.134e-744.00pep primary_assembly:ASM223467v1:13:32568675:32574... [more]
mid21.880e-736.59midline 2 [Source:NCBI gene;Acc:101175413][more]
mid21.940e-736.59midline 2 [Source:NCBI gene;Acc:101175413][more]
mid21.941e-736.59midline 2 [Source:NCBI gene;Acc:101175413][more]
ENSORLT00000022213.22.158e-741.38tripartite motif-containing protein 16-like [Sourc... [more]
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BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081132.10.000e+099.81SMESG000081132.1[more]
SMESG000020467.12.049e-5629.31SMESG000020467.1[more]
SMESG000069646.11.268e-3826.39SMESG000069646.1[more]
SMESG000064098.14.729e-3828.57SMESG000064098.1[more]
SMESG000064098.17.325e-3828.57SMESG000064098.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000311 ID=SMED30000311|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2087bp
GCTATGACATAATTATTTTCATTAAATCTAAATTAACTCCTGTGAACAAT
TTCGCTTTGTTTAATTGGTCGCTGCTTATGAGTCATCGATTGGTTGGATA
GAAAAACTCTAGCACACCTTCTGCTATAATAGAATTCTAGTATAATTTCC
ATTTGTAAATATTGATTACTTTCTGTTATGTGAATTCGAGTGCAAGTAGA
CGATTATTAATTAGATTTTGAAAATGAGCGTAAAATGGACTGAAAGGAGA
TTTTCCAAATCCTTACAATTGGAAGAACAAAAGGACTTTCTAGCACGAAA
AAATAGTATTTTGCCATCAGAACCTCTCGAGGACATGGTCTCATGTCCAA
TTCATCTTGGCATATTAGAGCGGCCTATTCAGTTGCCATGTGGCCATTCA
TTTTGTTTGGAATGCATAGAAAGATGCCTCAAAACTCAAATGCTTCAAAA
CAATCATTTTGCTTGCCCAGTTTGTCGAGTTAGTTGGCCCGTTCCATTAG
AAGGAGCCCATGGATGGCCGCAATCGTATGCTCTGAATGATATTATTACA
TACGTCCAAGAAGAAAAGCAAAAGAAATTATCTGGAAAATCATCACAAAA
GTATCGAAACAGTAATTCAAACAGAAAAAATTCAATTATCGAAAAAGCTG
ACATTGTTAAAAAGTTAGCTGAAGATATTGCTAATAAAAAATTAAGCGAC
GGTTCCGTAGATAAAGCATTCTTGATAACGGAATTGAATTCCATTTTAAA
GAAGTTACAAGAACCATCAACACCCGTTAATAATGTGGAAAACTCTGGGA
GTCGACGGAGCTCATTTGAATTGAAAATAGAAACCGAAGTGACTAGGGAG
CAGATGAGCAAGTTGTGTGAATACAAAGTTATACAAGAAAGATTGTCAGA
GGAGGTTCTCAAAGAGCTGATGAAATCCCCAGCAAAAGATAGTGTTGATT
TAGATGAGGATCCACAATTCAGAAAGCTTGTTTTTGTGAATACTAGTCAT
GAAATTGTTATTTATGATTGTAACACAGAAACCAGTACTAGTTTTGTACC
CATGTACTACAGTGATTGCTTAAAACCAGTCTTTCTTCGCTTTTTTCAAG
ATCTTGTTTTTGTCAGCGGTCTCATTTATTCGAAAGATGATGGTTCTGTT
CTAGCTGGAGTTTTAGTGAAATATAGTCTCGATGGAAAAATGATTGATGC
CTCCCAACGATACACAAAACAAAACAATGAGTACTTACCGGTGCACGGAT
TCGACATTGATACACAAGGAAATGTTTATCTCGCTCAACCTGACATGGCA
ACAATTACCGTCATGACGTCTGATCTGAAAGAAAATGAAGACAAATTTGT
ATTCAACGAGCCGGAATTGCATCCGACATTTGTTTGCTTTTGTAAATTAA
CGAAAGAAATCTGGGCGTCATGCCCTGCACATAAATCTATTCTCATTCTT
GACAGTGTCACTGGTAGCTATATGCAATTCGGCACCATTCAACTGTTCAA
TTCAGAGCCCGCTCATATCATCTCGACACAGGACAATAAGATTTGCTTTC
TCGATTCGAAATTATCGCGAGTTTTCTGGATCAAGCGACAAAACGAATAT
CTCTGTATTCAGCGGTTGGCGTTTGGTACAACTTTGAAAAAGGCCAATTT
TAGTTTGTTGCGCGGATTTTGCAATTCAAGTGCTTTATTGTTGATAACCG
ACAAATCAGTATTCACCTCCAAACCTTGCAAAAATACAGAGAAGGGTCCA
TCCTCGTCATCACACGTCAATTGTTGTGCAATTATGTAATTTAATTGATT
AGATTTATTTGTTTTGTGATTGATTATTAATTTATTTGTGATAATTTTCT
CGTTTATAGATAGTCTTTATAATGTATTATTTGAGTTATCGAATCGGGTC
CTTATATTAAATTGAGAATTTCTTTATTAATTATTGTCAAGATTTATATT
TTCCAAACAGAACAAAATTCGTATTTAAATGTTTCAAAATGAAAAGAAAA
ATGTTATCTATTTTAAATTTTTGTTTAGATATCAAAGATCACTTTGGGGG
GGTCAAATTAAATGTATTGTTCTACTTGCAATGTGAT
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protein sequence of SMED30000311-orf-1

>SMED30000311-orf-1 ID=SMED30000311-orf-1|Name=SMED30000311-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=522bp
MSVKWTERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILER
PIQLPCGHSFCLECIERCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQ
SYALNDIITYVQEEKQKKLSGKSSQKYRNSNSNRKNSIIEKADIVKKLAE
DIANKKLSDGSVDKAFLITELNSILKKLQEPSTPVNNVENSGSRRSSFEL
KIETEVTREQMSKLCEYKVIQERLSEEVLKELMKSPAKDSVDLDEDPQFR
KLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGL
IYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDIDTQGN
VYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASC
PAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRV
FWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKSVFTSK
PCKNTEKGPSSSSHVNCCAIM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000418head
PLANA:0002056medial muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR001841Znf_RING
IPR0110426-blade_b-propeller_TolB-like
IPR013083Znf_RING/FYVE/PHD
IPR017907Znf_RING_CS
IPR011528NERD
Vocabulary: molecular function
TermDefinition
GO:0008270zinc ion binding
GO:0005515protein binding
GO:0004842ubiquitin-protein transferase activity
GO:0008329signaling pattern recognition receptor activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0000932P-body
GO:0005622intracellular
GO:0005634nucleus
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0002218activation of innate immune response
GO:0002221pattern recognition receptor signaling pathway
GO:0002376immune system process
GO:0006914autophagy
GO:0016567protein ubiquitination
GO:0031664regulation of lipopolysaccharide-mediated signaling pathway
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410positive regulation of MAPK cascade
GO:0045087innate immune response
GO:0051092positive regulation of NF-kappaB transcription factor activity
GO:0051607defense response to virus
GO:0070534protein K63-linked ubiquitination
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001841Zinc finger, RING-typeSMARTSM00184ring_2coord: 41..84
e-value: 2.0E-4
score: 30.7
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 41..85
score: 10.984
NoneNo IPR availablePFAMPF15227zf-C3HC4_4coord: 41..84
e-value: 1.2E-8
score: 34.9
NoneNo IPR availablePANTHERPTHR25464:SF3E3 UBIQUITIN-PROTEIN LIGASE TRIM32coord: 34..187
NoneNo IPR availablePANTHERPTHR25464FAMILY NOT NAMEDcoord: 34..187
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 33..89
NoneNo IPR availableSUPERFAMILYSSF101898NHL repeatcoord: 243..464
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 12..148
e-value: 1.8E-16
score: 62.0
IPR017907Zinc finger, RING-type, conserved sitePROSITEPS00518ZF_RING_1coord: 56..65