CDGSH iron-sulfur domain-containing protein

Overview
NameCDGSH iron-sulfur domain-containing protein
Smed IDSMED30000305
Length (bp)454
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of CDGSH iron-sulfur domain-containing protein (SMED30000305) t-SNE clustered cells

Violin plots show distribution of expression levels for CDGSH iron-sulfur domain-containing protein (SMED30000305) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of CDGSH iron-sulfur domain-containing protein (SMED30000305) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for CDGSH iron-sulfur domain-containing protein (SMED30000305) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000305

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30000305h1SMcG0006395 dd_Smed_v4_2098_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30000305h1SMcG0006395 dd_Smed_v4_2098_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30000305h1SMcG0006395 dd_Smed_v4_2098_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Human
Match: CISD2 (CDGSH iron sulfur domain 2 [Source:HGNC Symbol;Acc:HGNC:24212])

HSP 1 Score: 112.464 bits (280), Expect = 4.905e-32
Identity = 60/135 (44.44%), Postives = 75/135 (55.56%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      +   LP  LK LP+P        LT  + ++L  F GV + +GY        +    +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:    1 MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQK--DSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Human
Match: CISD1 (CDGSH iron sulfur domain 1 [Source:HGNC Symbol;Acc:HGNC:30880])

HSP 1 Score: 100.523 bits (249), Expect = 1.010e-27
Identity = 49/106 (46.23%), Postives = 71/106 (66.98%), Query Frame = 2 
Query:  122 SLTFGDLMKLTVFCGVSSGVG-YCIYFTVHNRF--SHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            SLT    +++     V+   G   I +  + RF    HR+    +NL I+K++ K+V++F++E+L +K+V CRCWRSKKFP+CDG+H  HN +TGDNVGPLII KK
Sbjct:    2 SLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNK-AMINLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLIIKKK 106
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Human
Match: CISD2 (CDGSH iron sulfur domain 2 [Source:HGNC Symbol;Acc:HGNC:24212])

HSP 1 Score: 95.5153 bits (236), Expect = 2.426e-25
Identity = 49/101 (48.51%), Postives = 62/101 (61.39%), Query Frame = 2 
Query:  131 FGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            F + ++L  F GV + +GY        +    +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:   45 FSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQK--DSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKK 143
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Celegans
Match: cisd-1 (CDGSH Iron Sulfur Domain protein homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC71])

HSP 1 Score: 83.1889 bits (204), Expect = 4.271e-21
Identity = 44/135 (32.59%), Postives = 67/135 (49.63%), Query Frame = 2 
Query:   32 VLGLFNNFICNYLPN-----TLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLII 421
             L L  +  C   P       L  +P P + +     T   ++           +GY + +    R +         N  I+ +S K+V++ +IE++ EK   CRCW+S+K+PYCDGSH  HN +TGDNVGPLI+
Sbjct:    8 ALSLIQDHCCWTTPQHCSVAELGTMPCPTQVSGRCVATTAAVLAGGAL------IGYLVGYKFGQRSAR-------CNYKIQLDSNKIVDTVDIEDIGEKKAFCRCWKSEKWPYCDGSHGKHNKETGDNVGPLIV 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Celegans
Match: cisd-1 (CDGSH Iron Sulfur Domain protein homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC71])

HSP 1 Score: 83.1889 bits (204), Expect = 4.271e-21
Identity = 44/135 (32.59%), Postives = 67/135 (49.63%), Query Frame = 2 
Query:   32 VLGLFNNFICNYLPN-----TLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLII 421
             L L  +  C   P       L  +P P + +     T   ++           +GY + +    R +         N  I+ +S K+V++ +IE++ EK   CRCW+S+K+PYCDGSH  HN +TGDNVGPLI+
Sbjct:    8 ALSLIQDHCCWTTPQHCSVAELGTMPCPTQVSGRCVATTAAVLAGGAL------IGYLVGYKFGQRSAR-------CNYKIQLDSNKIVDTVDIEDIGEKKAFCRCWKSEKWPYCDGSHGKHNKETGDNVGPLIV 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Celegans
Match: cisd-1 (CDGSH Iron Sulfur Domain protein homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC71])

HSP 1 Score: 82.0333 bits (201), Expect = 4.999e-21
Identity = 37/80 (46.25%), Postives = 53/80 (66.25%), Query Frame = 2 
Query:  182 GYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLII 421
            G  I + V  +F    +     N  I+ +S K+V++ +IE++ EK   CRCW+S+K+PYCDGSH  HN +TGDNVGPLI+
Sbjct:   22 GALIGYLVGYKFGQRSAR---CNYKIQLDSNKIVDTVDIEDIGEKKAFCRCWKSEKWPYCDGSHGKHNKETGDNVGPLIV 98
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Celegans
Match: cisd-1 (CDGSH Iron Sulfur Domain protein homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC71])

HSP 1 Score: 82.0333 bits (201), Expect = 4.999e-21
Identity = 37/80 (46.25%), Postives = 53/80 (66.25%), Query Frame = 2 
Query:  182 GYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLII 421
            G  I + V  +F    +     N  I+ +S K+V++ +IE++ EK   CRCW+S+K+PYCDGSH  HN +TGDNVGPLI+
Sbjct:   22 GALIGYLVGYKFGQRSAR---CNYKIQLDSNKIVDTVDIEDIGEKKAFCRCWKSEKWPYCDGSHGKHNKETGDNVGPLIV 98
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Fly
Match: Cisd2 (gene:FBgn0062442 transcript:FBtr0085405)

HSP 1 Score: 103.605 bits (257), Expect = 6.835e-29
Identity = 51/130 (39.23%), Postives = 73/130 (56.15%), Query Frame = 2 
Query:   44 FNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTV--HNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITK 427
             ++ + + LPN L +LP+P        L+F D + L     V +G+GY  Y       R S      G  N  I K   KVV+  ++E++ EK+  CRCW++K +PYCDGSH  HN +TGDNVGP++I K
Sbjct:    4 ISHLVKSSLPNYLSSLPVPDSIGGWFKLSFKDWLALIPPTVVVAGLGYTAYLAYCPAARASCAAKNSGRCNNHIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Match: zgc:110843 (zgc:110843 [Source:ZFIN;Acc:ZDB-GENE-050327-15])

HSP 1 Score: 105.145 bits (261), Expect = 1.428e-29
Identity = 50/95 (52.63%), Postives = 63/95 (66.32%), Query Frame = 2 
Query:  146 KLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            +LT    V+       Y  +   FS   S    VNL+I K+S KVV+SF++E++  K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII KK
Sbjct:   26 QLTTIVPVAVAAALSTYMLMR-YFSSQSSPKSRVNLTINKDSPKVVHSFDMEDIGSKAVYCRCWRSKKFPYCDGAHAKHNEETGDNVGPLIIKKK 119
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Match: cisd1 (CDGSH iron sulfur domain 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1162])

HSP 1 Score: 98.9821 bits (245), Expect = 2.512e-27
Identity = 45/87 (51.72%), Postives = 64/87 (73.56%), Query Frame = 2 
Query:  170 SSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            ++ VG  +Y T    F + +     VNL ++K++ KVV++F+IE+L +K+V CRCWRSKKFP+CDG+H  HN +TGDNVGPLII +K
Sbjct:   22 AAAVGLLVYKTF---FHNSKCVKPKVNLDLQKDNPKVVHAFDIEDLGDKAVYCRCWRSKKFPFCDGAHAKHNQETGDNVGPLIIKRK 105
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Match: cisd1 (CDGSH iron sulfur domain 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1162])

HSP 1 Score: 98.9821 bits (245), Expect = 2.512e-27
Identity = 45/87 (51.72%), Postives = 64/87 (73.56%), Query Frame = 2 
Query:  170 SSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            ++ VG  +Y T    F + +     VNL ++K++ KVV++F+IE+L +K+V CRCWRSKKFP+CDG+H  HN +TGDNVGPLII +K
Sbjct:   22 AAAVGLLVYKTF---FHNSKCVKPKVNLDLQKDNPKVVHAFDIEDLGDKAVYCRCWRSKKFPFCDGAHAKHNQETGDNVGPLIIKRK 105
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Match: cisd2 (CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:393354])

HSP 1 Score: 93.9745 bits (232), Expect = 5.610e-25
Identity = 58/135 (42.96%), Postives = 75/135 (55.56%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSV-LCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL   +  I   LP  LK LP+P        LT  + ++L    G+ + +GY        +    R  D  +NL I+KE+ KVVN  +IE+L   +V  CRCWRSK FP CD SH+ HN  TGDNVGPLI+ KK
Sbjct:    1 MVLESISKIIKIQLPAYLKKLPLPETIGGFARLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQR--DSLINLKIQKENPKVVNEIDIEDLRTPNVCYCRCWRSKTFPVCDKSHIKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Match: cisd2 (CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:393354])

HSP 1 Score: 52.7582 bits (125), Expect = 3.268e-9
Identity = 39/107 (36.45%), Postives = 54/107 (50.47%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSV-LCRCWRSK 346
            MVL   +  I   LP  LK LP+P        LT  + ++L    G+ + +GY        +    R  D  +NL I+KE+ KVVN  +IE+L   +V  CRCWRSK
Sbjct:    1 MVLESISKIIKIQLPAYLKKLPLPETIGGFARLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQR--DSLINLKIQKENPKVVNEIDIEDLRTPNVCYCRCWRSK 105
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Xenopus
Match: copa (coatomer protein complex subunit alpha [Source:Xenbase;Acc:XB-GENE-989762])

HSP 1 Score: 114.005 bits (284), Expect = 2.099e-32
Identity = 63/135 (46.67%), Postives = 76/135 (56.30%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELP-EKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      I   LP  LK LPIP   A    LT  + ++L  F GV + +GY        +    +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:   31 MVLESIARVIKVQLPAYLKRLPIPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQK--DSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKK 163
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Xenopus
Match: cisd1 (CDGSH iron sulfur domain 1 [Source:NCBI gene;Acc:448057])

HSP 1 Score: 95.5153 bits (236), Expect = 6.427e-26
Identity = 44/88 (50.00%), Postives = 62/88 (70.45%), Query Frame = 2 
Query:  167 VSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
             ++ VGY  Y ++       +     VN  ++K++ KVV++F++E+L +K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII KK
Sbjct:   17 ATAAVGYIAYKSL---CCKDKCCKARVNPDLQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPYCDGAHTKHNEETGDNVGPLIIKKK 101
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Xenopus
Match: cisd1 (CDGSH iron sulfur domain 1 [Source:NCBI gene;Acc:448057])

HSP 1 Score: 95.5153 bits (236), Expect = 9.701e-26
Identity = 44/88 (50.00%), Postives = 63/88 (71.59%), Query Frame = 2 
Query:  167 VSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
             ++ VGY  Y ++  +    +     VN  ++K++ KVV++F++E+L +K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII KK
Sbjct:   22 ATAAVGYIAYKSLCCK---DKCCKARVNPDLQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPYCDGAHTKHNEETGDNVGPLIIKKK 106
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Xenopus
Match: copa (coatomer protein complex subunit alpha [Source:Xenbase;Acc:XB-GENE-989762])

HSP 1 Score: 72.4034 bits (176), Expect = 3.058e-16
Identity = 43/107 (40.19%), Postives = 55/107 (51.40%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELP-EKSVLCRCWRSK 346
            MVL      I   LP  LK LPIP   A    LT  + ++L  F GV + +GY        +    +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK
Sbjct:   31 MVLESIARVIKVQLPAYLKRLPIPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQK--DSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSK 135
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Mouse
Match: Cisd2 (CDGSH iron sulfur domain 2 [Source:MGI Symbol;Acc:MGI:1914256])

HSP 1 Score: 114.775 bits (286), Expect = 4.548e-33
Identity = 63/136 (46.32%), Postives = 76/136 (55.88%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRST-DGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      +   LP  LK LP+P        LT  D ++L  F GV + +GY     V   F   +   D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:    1 MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLGY---LAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Mouse
Match: Cisd1 (CDGSH iron sulfur domain 1 [Source:MGI Symbol;Acc:MGI:1261855])

HSP 1 Score: 105.531 bits (262), Expect = 7.916e-30
Identity = 46/98 (46.94%), Postives = 67/98 (68.37%), Query Frame = 2 
Query:  137 DLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            + +    F   ++ +GY  Y      ++    T   VNL I+K++ KVV++F++E+L +K+V CRCWRSKKFP+CDG+H+ HN +TGDNVGPLII KK
Sbjct:   12 EWIAAVTFAAGTAALGYLAY---KKFYAKENRTKAMVNLQIQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHIKHNEETGDNVGPLIIKKK 106
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Mouse
Match: Cisd2 (CDGSH iron sulfur domain 2 [Source:MGI Symbol;Acc:MGI:1914256])

HSP 1 Score: 73.559 bits (179), Expect = 2.187e-17
Identity = 43/108 (39.81%), Postives = 55/108 (50.93%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRST-DGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSK 346
            MVL      +   LP  LK LP+P        LT  D ++L  F GV + +G   Y  V   F   +   D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK
Sbjct:    1 MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLG---YLAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSK 105
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Match: sp|C3ZWH9|CID2A_BRAFL (CDGSH iron-sulfur domain-containing protein 2 homolog A OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_285975 PE=3 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 6.806e-33
Identity = 56/122 (45.90%), Postives = 71/122 (58.20%), Query Frame = 2 
Query:   65 YLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            ++P+ L ++P+P  F     LT G  + L  F G    V   +Y +V          D  VNL I+KES KVVN  +IE+L  K   CRCWRSKKFP CDGSH  HN  TGDNVGPL++ +K
Sbjct:   11 HIPDYLNSVPVPDSFGGFLDLTAGQWLHLFAFSGT---VAAAVYMSVKPYLDKKDQKDQLVNLRIQKESSKVVNMVDIEDLGNKVCYCRCWRSKKFPLCDGSHAKHNEDTGDNVGPLVLKRK 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Match: sp|C4A0P0|CID2B_BRAFL (CDGSH iron-sulfur domain-containing protein 2 homolog B OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_274541 PE=3 SV=1)

HSP 1 Score: 115.931 bits (289), Expect = 9.749e-33
Identity = 56/122 (45.90%), Postives = 71/122 (58.20%), Query Frame = 2 
Query:   65 YLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            ++P+ L ++P+P  F     LT G  + L  F G    V   +Y +V          D  VNL I+KES KVVN  +IE+L  K   CRCWRSKKFP CDGSH  HN  TGDNVGPL++ +K
Sbjct:   11 HIPDYLNSVPVPDSFGGFLDLTAGQWLHLFAFSGT---VAAAVYVSVKPYLDKKDQKDQLVNLRIQKESSKVVNMVDIEDLGNKVCYCRCWRSKKFPLCDGSHAKHNEDTGDNVGPLVLKRK 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CQB5|CISD2_MOUSE (CDGSH iron-sulfur domain-containing protein 2 OS=Mus musculus OX=10090 GN=Cisd2 PE=1 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 3.181e-32
Identity = 63/136 (46.32%), Postives = 76/136 (55.88%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRST-DGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      +   LP  LK LP+P        LT  D ++L  F GV + +GY     V   F   +   D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:    1 MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLGY---LAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5I027|CISD2_XENTR (CDGSH iron-sulfur domain-containing protein 2 OS=Xenopus tropicalis OX=8364 GN=cisd2 PE=2 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 3.955e-32
Identity = 63/135 (46.67%), Postives = 76/135 (56.30%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELP-EKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      I   LP  LK LPIP   A    LT  + ++L  F GV + +GY        +    +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:    1 MVLESIARVIKVQLPAYLKRLPIPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQK--DSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6PCF8|CID2A_XENLA (CDGSH iron-sulfur domain-containing protein 2A OS=Xenopus laevis OX=8355 GN=cisd2-a PE=2 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 4.042e-32
Identity = 63/135 (46.67%), Postives = 75/135 (55.56%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEEL-PEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL      I   LP  LK LPIP   A    LT  + ++L  F GV + +GY             +  D  +NL I+KE+ KVVN  NIE+L   K+  CRCWRSK FP CDGSH  HN  TGDNVGPLI+ KK
Sbjct:    1 MVLESIARVIKVQLPAYLKRLPIPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFL--LKKKQQKDSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Match: A0A5K3EU81 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 3.067e-34
Identity = 60/132 (45.45%), Postives = 87/132 (65.91%), Query Frame = 2 
Query:   35 LGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            + + +N +  +LPNTL+++PIP   +   SL+  ++  LT+F GVS+ +GY ++FTV +  S      G +N  ++K   KVV+  +IE + EK V CRCW+SKKFP CDG+H  HN +TGDNVGPLII  K
Sbjct:    1 MNILSNTVRVHLPNTLRDVPIPDSLSGFFSLSLKEMFGLTIFGGVSAALGYSVFFTVRSFLS-----SGHLNTMVKKNQEKVVDFVDIESIHEKKVFCRCWKSKKFPLCDGAHNKHNQETGDNVGPLIIEVK 127
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Match: A0A1S3I631 (CDGSH iron-sulfur domain-containing protein 2 homolog A-like OS=Lingula unguis OX=7574 GN=LOC106161326 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.906e-33
Identity = 61/121 (50.41%), Postives = 76/121 (62.81%), Query Frame = 2 
Query:   68 LPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            LPN LKNLP P  F  L  ++ GD ++L  F G    V   +YFTV       +     +N  I+KE  KV  + +IE+L EKSV CRCWRSKKFPYCDG+H  HN +TGDNVGPL+I +K
Sbjct:   12 LPNYLKNLPFPDSFEGLADMSGGDWLRLLPFVGT---VSLMVYFTVQAFLPSKKKIP--INPDIQKECEKVATAVDIEDLAEKSVFCRCWRSKKFPYCDGTHNAHNKETGDNVGPLVIKRK 127
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Match: A0A1S3IS31 (CDGSH iron-sulfur domain-containing protein 2 homolog A OS=Lingula unguis OX=7574 GN=LOC106166640 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 2.126e-33
Identity = 61/121 (50.41%), Postives = 76/121 (62.81%), Query Frame = 2 
Query:   68 LPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            LPN LKNLP P  F  L  ++ GD ++L  F G    V   +YFTV       +     +N  I+KE  KV  + +IE+L EKSV CRCWRSKKFPYCDG+H  HN +TGDNVGPL+I +K
Sbjct:   12 LPNYLKNLPFPDSFEGLADMSGGDWLRLLPFVGT---VSLMVYFTVQAFLPSKKKIP--INPDIQKECEKVATAVDIEDLAEKSVFCRCWRSKKFPYCDGTHNAHNKETGDNVGPLVIKRK 127
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Match: A0A3P7P9Q4 (ZnF_CDGSH domain-containing protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS18663 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 2.583e-33
Identity = 56/132 (42.42%), Postives = 85/132 (64.39%), Query Frame = 2 
Query:   35 LGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            +   ++ +C ++P+ L+++PIP  F  L SL+F +L++L+VF   S+ V Y +Y+T  +  S   ++ G +N   +KE  K V+  +IE + +K   CRCW S KFPYCDG+H  HN +TGDNVGPLII  K
Sbjct:    1 MNAIHSLVCVHVPSVLQSVPIPKTFRGLASLSFKELIQLSVFTTFSAAVAYSVYYTARSLCS---ASSGHINRCYKKEQAKCVDIIDIETIDQKKCYCRCWLSSKFPYCDGAHNKHNKETGDNVGPLIIHPK 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Match: A0A430PWX1 (ZnF_CDGSH domain-containing protein OS=Schistosoma bovis OX=6184 GN=DC041_0012069 PE=4 SV=1)

HSP 1 Score: 123.25 bits (308), Expect = 2.976e-33
Identity = 57/132 (43.18%), Postives = 79/132 (59.85%), Query Frame = 2 
Query:   35 LGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            + + +  +C+  P+ L+++PIP  F D+  L+  D++ LTVF   S  +GY +Y TV       R     +N  I K   K V+  +IE + +K V CRCWRS KFPYCDG+H  HN +TGDNVGPLII  K
Sbjct:    1 MNILHTIVCDIAPDMLRSVPIPKSFRDIFRLSLKDVLALTVFGSFSGAIGYAVYTTVMLHLGKRRI---LINNDIRKHITKCVDVVDIESITDKKVYCRCWRSSKFPYCDGAHNKHNEETGDNVGPLIIETK 129
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Cavefish
Match: cisd1 (CDGSH iron-sulfur domain-containing protein 1 [Source:NCBI gene;Acc:103031576])

HSP 1 Score: 104.76 bits (260), Expect = 1.076e-29
Identity = 50/103 (48.54%), Postives = 69/103 (66.99%), Query Frame = 2 
Query:  122 SLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            +++  DL+        ++ VG  +Y T    FS  +     VNL I+K++ KVV++F+IE+L +K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII  K
Sbjct:    6 AMSKADLIAAISVTAGAAAVGLLVYKTF---FSKGKCVKPKVNLDIQKDNPKVVHAFDIEDLGDKAVYCRCWRSKKFPYCDGAHAKHNQETGDNVGPLIIKHK 105
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Cavefish
Match: zgc:110843 (CDGSH iron-sulfur domain-containing protein 1-like [Source:NCBI gene;Acc:103035656])

HSP 1 Score: 100.908 bits (250), Expect = 6.395e-28
Identity = 46/78 (58.97%), Postives = 58/78 (74.36%), Query Frame = 2 
Query:  197 FTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            F +   FS    + G VNL   K+S KVV+SF+IE++ +K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII +K
Sbjct:   42 FLLTRYFSTQSCSKGKVNLEHNKDSAKVVHSFDIEDIGKKAVYCRCWRSKKFPYCDGAHTKHNEETGDNVGPLIIKRK 119
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Cavefish
Match: zgc:110843 (CDGSH iron-sulfur domain-containing protein 1-like [Source:NCBI gene;Acc:103035656])

HSP 1 Score: 100.138 bits (248), Expect = 1.260e-27
Identity = 46/78 (58.97%), Postives = 58/78 (74.36%), Query Frame = 2 
Query:  197 FTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            F +   FS    + G VNL   K+S KVV+SF+IE++ +K+V CRCWRSKKFPYCDG+H  HN +TGDNVGPLII +K
Sbjct:   41 FLLTRYFSTQSCSKGKVNLEHNKDSAKVVHSFDIEDIGKKAVYCRCWRSKKFPYCDGAHTKHNEETGDNVGPLIIKRK 118
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Cavefish
Match: cisd2 (CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:103046002])

HSP 1 Score: 93.2041 bits (230), Expect = 9.202e-25
Identity = 58/135 (42.96%), Postives = 75/135 (55.56%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSV-LCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL   +  I   LP  LK LP+P        LT  + ++L    G+ + +GY        +    R  D  +NL I+KE+ KVVN  +IE+L   +V  CRCWRSK FP CD SH+ HN  TGDNVGPLI+ KK
Sbjct:    1 MVLETISKIIKVQLPAYLKKLPLPETIGGFTRLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQR--DCLINLKIQKENPKVVNEIDIEDLRSPNVCYCRCWRSKTFPVCDKSHIKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Sea Lamprey
Match: cisd2 (CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:393354])

HSP 1 Score: 95.5153 bits (236), Expect = 2.360e-26
Identity = 48/103 (46.60%), Postives = 63/103 (61.17%), Query Frame = 2 
Query:  125 LTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPE-KSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            L  G+ ++L  F  + + +GY     +  R    +  D  +NL I+KE+ KVVN  NIE+  + K   CRCWRSK FP CDGSH  HN +TGDNVGPLII +K
Sbjct:   33 LAVGEWVRLLPFLSILALLGYLAIRPLLPR--KVKVKDSVINLKIQKETSKVVNEINIEDFVDAKKAYCRCWRSKTFPACDGSHNRHNEETGDNVGPLIIKRK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Sea Lamprey
Match: zgc:110843 (zgc:110843 [Source:ZFIN;Acc:ZDB-GENE-050327-15])

HSP 1 Score: 85.8853 bits (211), Expect = 5.685e-23
Identity = 38/62 (61.29%), Postives = 48/62 (77.42%), Query Frame = 2 
Query:  245 VNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            +N SI+KE+ KVV++ +  +L  +S  CRCWRSKKFPYCDG+H  HN  TGDNVGPL+IT K
Sbjct:   47 INPSIDKENPKVVHAMDTSDLGNESAFCRCWRSKKFPYCDGTHNKHNETTGDNVGPLVITVK 108
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Nematostella
Match: EDO30253 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1B0])

HSP 1 Score: 97.0561 bits (240), Expect = 6.137e-27
Identity = 50/117 (42.74%), Postives = 66/117 (56.41%), Query Frame = 2 
Query:   80 LKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            L+NLP P     +  L    +++L      +S V Y +      +       D  VNL  +K   KV +   IE++ +K+V CRCWRSKKFPYCDGSH  HN +TGDNVGPLI+ KK
Sbjct:    2 LENLPGPKSIGGIFKLDHNQVLQLVPLVATTSVVVYALVKCFMPK------KDEMVNLEKDKHEEKVADFVEIEDIGDKAVFCRCWRSKKFPYCDGSHGAHNKETGDNVGPLIVHKK 112
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Nematostella
Match: EDO42637 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S115])

HSP 1 Score: 58.9214 bits (141), Expect = 3.386e-12
Identity = 32/102 (31.37%), Postives = 50/102 (49.02%), Query Frame = 2 
Query:   44 FNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKK 349
             +  I + LP+ L+NLP+P     +  L    +++L      +S V Y +      +       D  VNL  +K   KV +   IE++ +K+V CRCWRSKK
Sbjct:    4 LSRLITSSLPHYLENLPVPKSIGGIFKLDHNQVLQLVPLVATTSVVVYALVKCFMPK------KDEMVNLEKDKHKEKVADFVEIEDIGDKAVFCRCWRSKK 99
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Medaka
Match: zgc:110843 (CDGSH iron-sulfur domain-containing protein 1 [Source:NCBI gene;Acc:101165687])

HSP 1 Score: 92.8189 bits (229), Expect = 1.059e-24
Identity = 43/78 (55.13%), Postives = 54/78 (69.23%), Query Frame = 2 
Query:  197 FTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            F +    +   S  G VN  I K+S KVV+ F++E++  K+V CRCW+SKKFP CDGSH  HN +TGDNVGPLII KK
Sbjct:   47 FFLSQYLNKRSSKKGQVNTFISKDSPKVVHCFDMEDIGSKAVYCRCWKSKKFPLCDGSHAAHNEQTGDNVGPLIIKKK 124
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Medaka
Match: cisd2 (CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:101158419])

HSP 1 Score: 91.2781 bits (225), Expect = 4.535e-24
Identity = 57/135 (42.22%), Postives = 76/135 (56.30%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSV-LCRCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK 430
            MVL   +  I   LP  LK LP+P        LT  + ++L    G+ + +GY        +    +  D  +NL I+KE+ KVVN  +IE+L  ++V  CRCWRSK FP CD SH+ HN  TGDNVGPLI+ KK
Sbjct:    1 MVLETISRIIKVQLPAYLKKLPLPESIGGFTKLTVSEWLRLLPLLGILALLGYLTIRPFLPK--KKKQKDSLINLKIQKENPKVVNEIDIEDLNCQNVCYCRCWRSKTFPVCDKSHLKHNELTGDNVGPLILKKK 133
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Planmine SMEST
Match: SMESG000056141.1 (SMESG000056141.1)

HSP 1 Score: 216.468 bits (550), Expect = 7.923e-74
Identity = 105/107 (98.13%), Postives = 106/107 (99.07%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKK 349
            MVLGLF+NFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSG GYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKK
Sbjct:    1 MVLGLFHNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGFGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKK 107
[Close]
BLAST of CDGSH iron-sulfur domain-containing protein vs. Planmine SMEST
Match: SMESG000056141.1 (SMESG000056141.1)

HSP 1 Score: 176.792 bits (447), Expect = 2.214e-58
Identity = 89/107 (83.18%), Postives = 90/107 (84.11%), Query Frame = 2 
Query:   29 MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGVGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLCRCWRSKK 349
            MVLGLF+NFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSG GYCIYFTVHNRFSHHRSTDG                FNIEELPEKSVLCRCWRSKK
Sbjct:    1 MVLGLFHNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSGFGYCIYFTVHNRFSHHRSTDG----------------FNIEELPEKSVLCRCWRSKK 91
The following BLAST results are available for this feature:
BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CISD24.905e-3244.44CDGSH iron sulfur domain 2 [Source:HGNC Symbol;Acc... [more]
CISD11.010e-2746.23CDGSH iron sulfur domain 1 [Source:HGNC Symbol;Acc... [more]
CISD22.426e-2548.51CDGSH iron sulfur domain 2 [Source:HGNC Symbol;Acc... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cisd-14.271e-2132.59CDGSH Iron Sulfur Domain protein homolog [Source:... [more]
cisd-14.271e-2132.59CDGSH Iron Sulfur Domain protein homolog [Source:... [more]
cisd-14.999e-2146.25CDGSH Iron Sulfur Domain protein homolog [Source:... [more]
cisd-14.999e-2146.25CDGSH Iron Sulfur Domain protein homolog [Source:... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Cisd26.835e-2939.23gene:FBgn0062442 transcript:FBtr0085405[more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
zgc:1108431.428e-2952.63zgc:110843 [Source:ZFIN;Acc:ZDB-GENE-050327-15][more]
cisd12.512e-2751.72CDGSH iron sulfur domain 1 [Source:ZFIN;Acc:ZDB-GE... [more]
cisd12.512e-2751.72CDGSH iron sulfur domain 1 [Source:ZFIN;Acc:ZDB-GE... [more]
cisd25.610e-2542.96CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:3... [more]
cisd23.268e-936.45CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:3... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
copa2.099e-3246.67coatomer protein complex subunit alpha [Source:Xen... [more]
cisd16.427e-2650.00CDGSH iron sulfur domain 1 [Source:NCBI gene;Acc:4... [more]
cisd19.701e-2650.00CDGSH iron sulfur domain 1 [Source:NCBI gene;Acc:4... [more]
copa3.058e-1640.19coatomer protein complex subunit alpha [Source:Xen... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Cisd24.548e-3346.32CDGSH iron sulfur domain 2 [Source:MGI Symbol;Acc:... [more]
Cisd17.916e-3046.94CDGSH iron sulfur domain 1 [Source:MGI Symbol;Acc:... [more]
Cisd22.187e-1739.81CDGSH iron sulfur domain 2 [Source:MGI Symbol;Acc:... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|C3ZWH9|CID2A_BRAFL6.806e-3345.90CDGSH iron-sulfur domain-containing protein 2 homo... [more]
sp|C4A0P0|CID2B_BRAFL9.749e-3345.90CDGSH iron-sulfur domain-containing protein 2 homo... [more]
sp|Q9CQB5|CISD2_MOUSE3.181e-3246.32CDGSH iron-sulfur domain-containing protein 2 OS=M... [more]
sp|Q5I027|CISD2_XENTR3.955e-3246.67CDGSH iron-sulfur domain-containing protein 2 OS=X... [more]
sp|Q6PCF8|CID2A_XENLA4.042e-3246.67CDGSH iron-sulfur domain-containing protein 2A OS=... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3EU813.067e-3445.45Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A1S3I6311.906e-3350.41CDGSH iron-sulfur domain-containing protein 2 homo... [more]
A0A1S3IS312.126e-3350.41CDGSH iron-sulfur domain-containing protein 2 homo... [more]
A0A3P7P9Q42.583e-3342.42ZnF_CDGSH domain-containing protein OS=Dibothrioce... [more]
A0A430PWX12.976e-3343.18ZnF_CDGSH domain-containing protein OS=Schistosoma... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cisd11.076e-2948.54CDGSH iron-sulfur domain-containing protein 1 [Sou... [more]
zgc:1108436.395e-2858.97CDGSH iron-sulfur domain-containing protein 1-like... [more]
zgc:1108431.260e-2758.97CDGSH iron-sulfur domain-containing protein 1-like... [more]
cisd29.202e-2542.96CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cisd22.360e-2646.60CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:3... [more]
zgc:1108435.685e-2361.29zgc:110843 [Source:ZFIN;Acc:ZDB-GENE-050327-15][more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO302536.137e-2742.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO426373.386e-1231.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
zgc:1108431.059e-2455.13CDGSH iron-sulfur domain-containing protein 1 [Sou... [more]
cisd24.535e-2442.22CDGSH iron sulfur domain 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of CDGSH iron-sulfur domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000056141.17.923e-7498.13SMESG000056141.1[more]
SMESG000056141.12.214e-5883.18SMESG000056141.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000305 ID=SMED30000305|Name=CDGSH iron-sulfur domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=454bp
TGAGAAAACAGTTTTAATTTAAATAATAATGGTTTTAGGATTATTCAACA
ATTTTATATGTAATTATTTACCAAATACATTGAAAAACTTACCAATTCCT
GCCAAATTCGCAGATCTTAAATCTCTTACATTTGGAGATTTGATGAAATT
GACCGTGTTCTGTGGTGTCAGTAGTGGCGTTGGATATTGTATTTATTTCA
CAGTTCATAATCGATTTAGTCATCATAGATCAACTGATGGGTTTGTTAAT
TTATCTATTGAAAAGGAGTCGGGTAAAGTTGTAAATAGTTTTAATATTGA
AGAATTACCAGAAAAATCTGTTTTATGTCGCTGTTGGAGATCGAAAAAGT
TTCCGTATTGTGATGGGAGTCACGTAGGACACAATAACAAAACTGGGGAT
AATGTAGGACCTCTAATAATTACTAAAAAATGATTTTTATTAGTTTTAAT
AAAA
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protein sequence of SMED30000305-orf-1

>SMED30000305-orf-1 ID=SMED30000305-orf-1|Name=SMED30000305-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=135bp
MVLGLFNNFICNYLPNTLKNLPIPAKFADLKSLTFGDLMKLTVFCGVSSG
VGYCIYFTVHNRFSHHRSTDGFVNLSIEKESGKVVNSFNIEELPEKSVLC
RCWRSKKFPYCDGSHVGHNNKTGDNVGPLIITKK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000101muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR042216FeS-contain_mitoNEET_C
IPR018967FeS-contain_CDGSH-typ
IPR019610FeS-contain_mitoNEET_N
Vocabulary: molecular function
TermDefinition
GO:00515372 iron, 2 sulfur cluster binding
Vocabulary: cellular component
TermDefinition
GO:0043231intracellular membrane-bounded organelle
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR018967Iron sulphur-containing domain, CDGSH-typeSMARTSM00704znf_cdgshcoord: 83..121
e-value: 1.7E-13
score: 60.9
IPR018967Iron sulphur-containing domain, CDGSH-typePFAMPF09360zf-CDGSHcoord: 76..115
e-value: 8.2E-11
score: 42.0
IPR042216Iron sulphur domain-containing, mitoNEET, C-terminalGENE3DG3DSA:3.40.5.90coord: 61..134
e-value: 2.0E-27
score: 96.9
IPR019610Iron sulphur domain-containing, mitoNEET, N-terminalPFAMPF10660MitoNEET_Ncoord: 6..59
e-value: 1.8E-11
score: 43.9
NoneNo IPR availablePANTHERPTHR13680FAMILY NOT NAMEDcoord: 36..134