GLI-3

Overview


Name	GLI-3 (ACZ64516.1)
Smed ID	SMED30000146
Length (bp)	1892

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of GLI-3 (SMED30000146) t-SNE clustered cells

Violin plots show distribution of expression levels for GLI-3 (SMED30000146) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GLI-3 (SMED30000146) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GLI-3 (SMED30000146) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30000146

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
pharynx	SMED30000146	SMESG000078300.1	dd_Smed_v4_17566_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30000146	SMESG000078300.1	dd_Smed_v4_17566_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of GLI-3 vs. Ensembl Human
Match: GLIS3 (GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:28510])

HSP 1 Score: 251.906 bits (642), Expect = 3.626e-73
Identity = 113/160 (70.62%), Postives = 128/160 (80.00%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  344 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQ 502

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BLAST of GLI-3 vs. Ensembl Human
Match: GLIS1 (GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:29525])

HSP 1 Score: 248.054 bits (632), Expect = 4.951e-73
Identity = 114/167 (68.26%), Postives = 130/167 (77.84%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASID 1182
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+A  D
Sbjct:  197 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPD 362

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BLAST of GLI-3 vs. Ensembl Human
Match: GLIS3 (GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:28510])

HSP 1 Score: 252.677 bits (644), Expect = 1.769e-72
Identity = 113/160 (70.62%), Postives = 128/160 (80.00%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  499 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQ 657

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BLAST of GLI-3 vs. Ensembl Human
Match: GLIS1 (GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:29525])

HSP 1 Score: 248.825 bits (634), Expect = 7.063e-72
Identity = 114/167 (68.26%), Postives = 130/167 (77.84%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASID 1182
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+A  D
Sbjct:  372 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPD 537

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BLAST of GLI-3 vs. Ensembl Human
Match: GLI2 (GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318])

HSP 1 Score: 201.83 bits (512), Expect = 3.494e-54
Identity = 89/151 (58.94%), Postives = 111/151 (73.51%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W DC + +   + LV+HI   H+     K E+ C WQ C+R+ KPF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  439 CHWEDCTKEYDTQEQLVHHINNEHI--HGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKT 587

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BLAST of GLI-3 vs. Ensembl Celegans
Match: tra-1 (Sex-determining transformer protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P34708])

HSP 1 Score: 187.963 bits (476), Expect = 4.903e-50
Identity = 91/187 (48.66%), Postives = 118/187 (63.10%), Query Frame = 1

Query:  589 GDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKD-EYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            G +  PQ N    SN    + +    D      L C W  C  SF   K+LV+H+++ HV     +   + C W+GC R  + F A Y L++H+R H+GEKPNKC+Y GC K +SRLENLK H R+HTGE+PY+C++  C KAFSN+SDRAKHQ RTH + KPY C +  C K YTDPSSLRKH K+
Sbjct:  181 GTFKRPQNNAANSSNSGNDSDMMGDHD------LTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRN-ETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKA 360

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BLAST of GLI-3 vs. Ensembl Celegans
Match: ref-2 (REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:Q7JNM3])

HSP 1 Score: 157.532 bits (397), Expect = 4.635e-43
Identity = 89/209 (42.58%), Postives = 118/209 (56.46%), Query Frame = 1

Query:  577 HSYSGDYYSPQINIHQFSNCNLSNQIY-TSIDSRPHPKLI-CFWID----CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNF-QSQLNASID 1182
            H+YS  +Y     +  F    +   IY  ++ S    K + C W      C     +   L  HI   H+   +   ++ C W+GC R+ K F A+YKL+ HMRVH+GE+P  C    C+K F+R ENLKIH+R H+GE+P+QC + GC K F+NSSDR KH   H   KPY C    CGK YT PSSLRKHTK H+N  +SQL+   D
Sbjct:   44 HAYSPSFYMNMSQVPHFLPAQVDPFIYPNTLGSYGGDKQVQCLWETNGQVCMHVCQNSGELSTHISSNHITHDS---KFVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMHVHSSHKPYSCMYPDCGKTYTHPSSLRKHTKVHENEKKSQLSPEHD 247

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BLAST of GLI-3 vs. Ensembl Celegans
Match: ref-2 (REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:Q7JNM3])

HSP 1 Score: 156.762 bits (395), Expect = 6.619e-43
Identity = 89/209 (42.58%), Postives = 118/209 (56.46%), Query Frame = 1

Query:  577 HSYSGDYYSPQINIHQFSNCNLSNQIY-TSIDSRPHPKLI-CFWID----CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNF-QSQLNASID 1182
            H+YS  +Y     +  F    +   IY  ++ S    K + C W      C     +   L  HI   H+   +   ++ C W+GC R+ K F A+YKL+ HMRVH+GE+P  C    C+K F+R ENLKIH+R H+GE+P+QC + GC K F+NSSDR KH   H   KPY C    CGK YT PSSLRKHTK H+N  +SQL+   D
Sbjct:   31 HAYSPSFYMNMSQVPHFLPAQVDPFIYPNTLGSYGGDKQVQCLWETNGQVCMHVCQNSGELSTHISSNHITHDS---KFVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMHVHSSHKPYSCMYPDCGKTYTHPSSLRKHTKVHENEKKSQLSPEHD 234

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Query:  577 HSYSGDYYSPQINIHQFSNCNLSNQIY-TSIDSRPHPKLI-CFWID----CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNF-QSQLNASID 1182
            H+YS  +Y     +  F    +   IY  ++ S    K + C W      C     +   L  HI   H+   +   ++ C W+GC R+ K F A+YKL+ HMRVH+GE+P  C    C+K F+R ENLKIH+R H+GE+P+QC + GC K F+NSSDR KH   H   KPY C    CGK YT PSSLRKHTK H+N  +SQL+   D
Sbjct:   31 HAYSPSFYMNMSQVPHFLPAQVDPFIYPNTLGSYGGDKQVQCLWETNGQVCMHVCQNSGELSTHISSNHITHDS---KFVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMHVHSSHKPYSCMYPDCGKTYTHPSSLRKHTKVHENEKKSQLSPEHD 234

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BLAST of GLI-3 vs. Ensembl Celegans
Match: ztf-14 (Zinc finger putative Transcription Factor family [Source:UniProtKB/TrEMBL;Acc:Q93902])

HSP 1 Score: 130.954 bits (328), Expect = 3.229e-32
Identity = 67/151 (44.37%), Postives = 85/151 (56.29%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKH-QRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W  C  +  D  +       +HVD    K+E  C W+ C R    F   Y+   H R H+ +K   C+   C K + RLENLK H R+HTGE+PY C    C K+F+N+SDR+KH +RTH + KPYCC    C   YTDPSSLRKH KS
Sbjct:  233 CLWDGCTLTLDDRATFF-----VHVDNHIQKNEVNCKWRYCERS---FKQTYEFTAHKRTHTKQKLYCCEV--CPKRYGRLENLKTHRRTHTGEKPYHCNVPNCNKSFTNASDRSKHSKRTHSNEKPYCCDFGSCACAYTDPSSLRKHVKS 373

HSP 2 Score: 49.6766 bits (117), Expect = 5.994e-6
Identity = 25/88 (28.41%), Postives = 41/88 (46.59%), Query Frame = 1

Query:  883 EKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            E   +C + GC           +H  +H  +    C++  C ++F  + +   H+RTH   K YCC V  C KRY    +L+ H ++H
Sbjct:  228 EDVRQCLWDGCTLTLDDRATFFVHVDNHIQKNEVNCKWRYCERSFKQTYEFTAHKRTHTKQKLYCCEV--CPKRYGRLENLKTHRRTH 313

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BLAST of GLI-3 vs. Ensembl Fly
Match: lmd (gene:FBgn0039039 transcript:FBtr0084364)

HSP 1 Score: 244.973 bits (624), Expect = 2.430e-70
Identity = 115/162 (70.99%), Postives = 128/162 (79.01%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH--QNFQSQL 1167
            LIC W  C + F   ++ V HIEK HVD R  +D ++CFW  C R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH+RSHTGERPY CQY GC KAFSNSSDRAKHQRTHYDTKPY C + GC KRYTDPSSLRKH K+H  +N   QL
Sbjct:  435 LICRWTGCDEEFPHQQAFVEHIEKCHVDVRKGED-FSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKHVKNHALRNANGQL 595

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BLAST of GLI-3 vs. Ensembl Fly
Match: ci (gene:FBgn0004859 transcript:FBtr0306168)

HSP 1 Score: 193.741 bits (491), Expect = 8.264e-52
Identity = 90/151 (59.60%), Postives = 106/151 (70.20%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W  C   F     LV HI   H+ Q N K  + C W+ C+R  KPF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGE+PY C+Y GC KAFSN+SDRAKHQ RTH + KPY C   GC KRYTDPSSLRKH K+
Sbjct:  335 CHWRSCRIEFITQDELVKHINNDHI-QTN-KKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKT 483

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BLAST of GLI-3 vs. Ensembl Fly
Match: ci (gene:FBgn0004859 transcript:FBtr0089178)

HSP 1 Score: 193.741 bits (491), Expect = 1.016e-51
Identity = 90/151 (59.60%), Postives = 106/151 (70.20%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W  C   F     LV HI   H+ Q N K  + C W+ C+R  KPF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGE+PY C+Y GC KAFSN+SDRAKHQ RTH + KPY C   GC KRYTDPSSLRKH K+
Sbjct:  453 CHWRSCRIEFITQDELVKHINNDHI-QTN-KKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKT 601

[Close]

BLAST of GLI-3 vs. Ensembl Fly
Match: sug (gene:FBgn0033782 transcript:FBtr0331985)

HSP 1 Score: 178.718 bits (452), Expect = 1.410e-50
Identity = 83/152 (54.61%), Postives = 103/152 (67.76%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
             +C W DC + F    +L  H+ + H         Y C W+GC R  + FNARYK+L+H R H+ EKP++C    C+K+FSR ENLKIH RSH+GE+PY+C + GC KA+SNSSDR KH RTH   KPY C VAGC KRYTDPSSLRKH K+
Sbjct:   66 FVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKT 215

[Close]

BLAST of GLI-3 vs. Ensembl Fly
Match: sug (gene:FBgn0033782 transcript:FBtr0087789)

HSP 1 Score: 179.104 bits (453), Expect = 3.899e-50
Identity = 83/155 (53.55%), Postives = 105/155 (67.74%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQN 1152
             +C W DC + F    +L  H+ + H         Y C W+GC R  + FNARYK+L+H R H+ EKP++C    C+K+FSR ENLKIH RSH+GE+PY+C + GC KA+SNSSDR KH RTH   KPY C VAGC KRYTDPSSLRKH K+ ++
Sbjct:  128 FVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKH 280

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BLAST of GLI-3 vs. Ensembl Zebrafish
Match: glis1b (GLIS family zinc finger 1b [Source:ZFIN;Acc:ZDB-GENE-081105-172])

HSP 1 Score: 245.358 bits (625), Expect = 5.956e-77
Identity = 113/162 (69.75%), Postives = 129/162 (79.63%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLN 1170
            K +C WIDC  ++   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K H   + Q+ 
Sbjct:   64 KQVCRWIDCSAAYEQQEELVRHIEKVHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCNKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKIHSAKEQQVR 224

[Close]

BLAST of GLI-3 vs. Ensembl Zebrafish
Match: glis1b (GLIS family zinc finger 1b [Source:ZFIN;Acc:ZDB-GENE-081105-172])

HSP 1 Score: 251.136 bits (640), Expect = 2.935e-73
Identity = 113/165 (68.48%), Postives = 130/165 (78.79%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASI 1179
            K +C WIDC  ++   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K H   + Q+   +
Sbjct:  482 KQVCRWIDCSAAYEQQEELVRHIEKVHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCNKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKIHSAKEQQVRRKL 645

[Close]

BLAST of GLI-3 vs. Ensembl Zebrafish
Match: glis1a (GLIS family zinc finger 1a [Source:ZFIN;Acc:ZDB-GENE-070912-8])

HSP 1 Score: 242.276 bits (617), Expect = 4.605e-72
Identity = 110/151 (72.85%), Postives = 124/151 (82.12%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            C W+DC  ++   + LV HIEK+H+DQR   +E+TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K H
Sbjct:  129 CKWMDCRATYGQREELVRHIEKIHIDQRK-GEEFTCFWAGCVRRHKPFNARYKLLIHMRVHSGEKPNKCMFEGCNKAFSRLENLKIHLRSHTGEKPYICQHPGCLKAFSNSSDRAKHQRTHLDTKPYACQLPGCTKRYTDPSSLRKHVKVH 278

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BLAST of GLI-3 vs. Ensembl Zebrafish
Match: glis3 (GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-070112-2232])

HSP 1 Score: 248.054 bits (632), Expect = 7.750e-72
Identity = 112/151 (74.17%), Postives = 123/151 (81.46%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            C W+ C   +    +LV HIEK+HVDQR  +D +TCFW GC+RK KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY C + GC KAFSNSSDRAKHQRTH DTKPY C + GCGKRYTDPSSLRKH KSH
Sbjct:  386 CCWLHCGAIYSHRDALVKHIEKIHVDQRKGED-FTCFWAGCARKHKPFNARYKLLIHMRVHSGEKPNKCSFEGCQKAFSRLENLKIHLRSHTGEKPYVCPHPGCLKAFSNSSDRAKHQRTHVDTKPYACQIQGCGKRYTDPSSLRKHVKSH 535

[Close]

BLAST of GLI-3 vs. Ensembl Zebrafish
Match: glis3 (GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-070112-2232])

HSP 1 Score: 248.054 bits (632), Expect = 8.797e-72
Identity = 112/151 (74.17%), Postives = 123/151 (81.46%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            C W+ C   +    +LV HIEK+HVDQR  +D +TCFW GC+RK KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY C + GC KAFSNSSDRAKHQRTH DTKPY C + GCGKRYTDPSSLRKH KSH
Sbjct:  402 CCWLHCGAIYSHRDALVKHIEKIHVDQRKGED-FTCFWAGCARKHKPFNARYKLLIHMRVHSGEKPNKCSFEGCQKAFSRLENLKIHLRSHTGEKPYVCPHPGCLKAFSNSSDRAKHQRTHVDTKPYACQIQGCGKRYTDPSSLRKHVKSH 551

[Close]

BLAST of GLI-3 vs. Ensembl Xenopus
Match: GLIS3 (GLIS family zinc finger 3 [Source:NCBI gene;Acc:100496527])

HSP 1 Score: 252.292 bits (643), Expect = 1.361e-73
Identity = 123/213 (57.75%), Postives = 146/213 (68.54%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRR 1323
            K  C WIDC   +   + LV HIEK+H+DQR  +D + CFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H +   Q    +        +S +  D +I++D   + PL+  +     PQ P+  S  R
Sbjct:  342 KHCCRWIDCSSMYEQQEELVRHIEKVHIDQRKGED-FACFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSSKDQQARKKL--------RSRTDLDQEILSDCLTIQPLQPAT----SPQDPSESSMGR 541

[Close]

BLAST of GLI-3 vs. Ensembl Xenopus
Match: GLIS3 (GLIS family zinc finger 3 [Source:NCBI gene;Acc:100496527])

HSP 1 Score: 252.292 bits (643), Expect = 2.262e-73
Identity = 123/213 (57.75%), Postives = 146/213 (68.54%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRR 1323
            K  C WIDC   +   + LV HIEK+H+DQR  +D + CFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H +   Q    +        +S +  D +I++D   + PL+  +     PQ P+  S  R
Sbjct:  342 KHCCRWIDCSSMYEQQEELVRHIEKVHIDQRKGED-FACFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSSKDQQARKKL--------RSRTDLDQEILSDCLTIQPLQPAT----SPQDPSESSMGR 541

[Close]

BLAST of GLI-3 vs. Ensembl Xenopus
Match: GLIS3 (GLIS family zinc finger 3 [Source:NCBI gene;Acc:100496527])

HSP 1 Score: 252.677 bits (644), Expect = 1.193e-72
Identity = 123/213 (57.75%), Postives = 146/213 (68.54%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRR 1323
            K  C WIDC   +   + LV HIEK+H+DQR  +D + CFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H +   Q    +        +S +  D +I++D   + PL+  +     PQ P+  S  R
Sbjct:  490 KHCCRWIDCSSMYEQQEELVRHIEKVHIDQRKGED-FACFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSSKDQQARKKL--------RSRTDLDQEILSDCLTIQPLQPAT----SPQDPSESSMGR 689

[Close]

BLAST of GLI-3 vs. Ensembl Xenopus
Match: GLI1 (GLI family zinc finger 1 [Source:NCBI gene;Acc:100494064])

HSP 1 Score: 203.371 bits (516), Expect = 8.530e-55
Identity = 92/164 (56.10%), Postives = 117/164 (71.34%), Query Frame = 1

Query:  667 DSRPHPKLI----CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            D +  P+ +    C W  C + F   + LV+HI   H+     K E+ C WQ CSR+L+PF A+Y L++HMR H+GEKP+KC + GC+KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  143 DGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGE--KKEFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKT 304

[Close]

BLAST of GLI-3 vs. Ensembl Xenopus
Match: GLI1 (GLI family zinc finger 1 [Source:NCBI gene;Acc:100494064])

HSP 1 Score: 202.986 bits (515), Expect = 1.313e-54
Identity = 92/164 (56.10%), Postives = 117/164 (71.34%), Query Frame = 1

Query:  667 DSRPHPKLI----CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            D +  P+ +    C W  C + F   + LV+HI   H+     K E+ C WQ CSR+L+PF A+Y L++HMR H+GEKP+KC + GC+KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  239 DGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGE--KKEFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKT 400

[Close]

BLAST of GLI-3 vs. Ensembl Mouse
Match: Glis1 (GLIS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:2386723])

HSP 1 Score: 249.21 bits (635), Expect = 8.228e-74
Identity = 114/169 (67.46%), Postives = 130/169 (76.92%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASIDPN 1188
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+   DP 
Sbjct:  180 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPE 347

[Close]

BLAST of GLI-3 vs. Ensembl Mouse
Match: Glis3 (GLIS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:2444289])

HSP 1 Score: 250.751 bits (639), Expect = 1.032e-73
Identity = 113/160 (70.62%), Postives = 127/160 (79.38%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  499 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQ 657

[Close]

BLAST of GLI-3 vs. Ensembl Mouse
Match: Glis1 (GLIS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:2386723])

HSP 1 Score: 249.98 bits (637), Expect = 1.501e-72
Identity = 114/169 (67.46%), Postives = 130/169 (76.92%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASIDPN 1188
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+   DP 
Sbjct:  368 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPE 535

[Close]

BLAST of GLI-3 vs. Ensembl Mouse
Match: Glis3 (GLIS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:2444289])

HSP 1 Score: 251.521 bits (641), Expect = 2.698e-72
Identity = 113/160 (70.62%), Postives = 127/160 (79.38%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  499 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQ 657

[Close]

BLAST of GLI-3 vs. Ensembl Mouse
Match: Gli2 (GLI-Kruppel family member GLI2 [Source:MGI Symbol;Acc:MGI:95728])

HSP 1 Score: 202.986 bits (515), Expect = 1.202e-54
Identity = 89/151 (58.94%), Postives = 111/151 (73.51%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W DC + +   + LV+HI   H+     K E+ C WQ C+R+ KPF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  419 CHWADCTKEYDTQEQLVHHINNEHI--HGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKT 567

[Close]

BLAST of GLI-3 vs. UniProt/SwissProt
Match: sp|Q8NEA6|GLIS3_HUMAN (Zinc finger protein GLIS3 OS=Homo sapiens OX=9606 GN=GLIS3 PE=1 SV=5)

HSP 1 Score: 251.906 bits (642), Expect = 1.741e-72
Identity = 113/160 (70.62%), Postives = 128/160 (80.00%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  344 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQ 502

[Close]

BLAST of GLI-3 vs. UniProt/SwissProt
Match: sp|Q8NBF1|GLIS1_HUMAN (Zinc finger protein GLIS1 OS=Homo sapiens OX=9606 GN=GLIS1 PE=1 SV=2)

HSP 1 Score: 248.054 bits (632), Expect = 2.378e-72
Identity = 114/167 (68.26%), Postives = 130/167 (77.84%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASID 1182
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+A  D
Sbjct:  197 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPD 362

[Close]

BLAST of GLI-3 vs. UniProt/SwissProt
Match: sp|Q6XP49|GLIS3_MOUSE (Zinc finger protein GLIS3 OS=Mus musculus OX=10090 GN=Glis3 PE=1 SV=2)

HSP 1 Score: 251.136 bits (640), Expect = 3.631e-72
Identity = 113/160 (70.62%), Postives = 127/160 (79.38%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            K  C WIDC   +   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H + + Q
Sbjct:  344 KHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGED-FTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQ 502

[Close]

BLAST of GLI-3 vs. UniProt/SwissProt
Match: sp|Q8K1M4|GLIS1_MOUSE (Zinc finger protein GLIS1 OS=Mus musculus OX=10090 GN=Glis1 PE=1 SV=2)

HSP 1 Score: 249.98 bits (637), Expect = 1.050e-71
Identity = 114/169 (67.46%), Postives = 130/169 (76.92%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH----QNFQSQLNASIDPN 1188
            C W+DC  ++   + LV HIEK H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH K+H    Q  + +L+   DP 
Sbjct:  368 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGED-FTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPE 535

[Close]

BLAST of GLI-3 vs. UniProt/SwissProt
Match: sp|Q91690|GLI1_XENLA (Zinc finger protein GLI1 (Fragment) OS=Xenopus laevis OX=8355 GN=gli1 PE=2 SV=2)

HSP 1 Score: 202.986 bits (515), Expect = 7.735e-54
Identity = 92/164 (56.10%), Postives = 117/164 (71.34%), Query Frame = 1

Query:  667 DSRPHPKLI----CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            D +  P+ +    C W  C + F   + LV+HI   H+     K E+ C WQ CSR+L+PF A+Y L++HMR H+GEKP+KC + GC+KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  239 DGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGE--KKEFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKT 400

[Close]

BLAST of GLI-3 vs. TrEMBL
Match: D2ILS5 (GLI-3 OS=Schmidtea mediterranea OX=79327 GN=gli-3 PE=2 SV=1)

HSP 1 Score: 1031.17 bits (2665), Expect = 0.000e+0
Identity = 496/499 (99.40%), Postives = 497/499 (99.60%), Query Frame = 1

Query:  283 MASILLNSSTSNRSVDPDYFAKSSISTSPPAKIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTSMQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL 1779
            MASILLNSSTSNRSVDPDYFAKSS+STSPP KIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVS RRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTSMQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL
Sbjct:    1 MASILLNSSTSNRSVDPDYFAKSSVSTSPPGKIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSGRRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTSMQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL 499

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BLAST of GLI-3 vs. TrEMBL
Match: X1YV67 (Uncharacterized protein OS=Capitella teleta OX=283909 PE=4 SV=1)

HSP 1 Score: 253.447 bits (646), Expect = 7.449e-77
Identity = 115/152 (75.66%), Postives = 129/152 (84.87%), Query Frame = 1

Query:  691 ICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            +C W+DC + F +   LV H+EK+H+DQR   DE+TCFWQGC R+ KPFNARYKLLIHMRVHSGEKPNKC ++GC+KAFSRLENLKIH RSHTGERPYQCQ+ GC KAFSNSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH K+H
Sbjct:   12 VCKWVDCQEVFAEQDELVRHLEKLHIDQRR-GDEFTCFWQGCQRRHKPFNARYKLLIHMRVHSGEKPNKCTFAGCNKAFSRLENLKIHMRSHTGERPYQCQHPGCLKAFSNSSDRAKHQRTHIDTKPYACTVPGCIKRYTDPSSLRKHQKNH 162

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BLAST of GLI-3 vs. TrEMBL
Match: A0A2J7PWE6 (Uncharacterized protein OS=Cryptotermes secundus OX=105785 GN=B7P43_G04055 PE=4 SV=1)

HSP 1 Score: 258.84 bits (660), Expect = 6.600e-76
Identity = 117/153 (76.47%), Postives = 128/153 (83.66%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            L C WIDCY  F D +SLV+HIEK HV+ R  +D ++CFWQGC R+ +PFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH+RSHTGERPY CQY GC KAFSNSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH K+H
Sbjct:  109 LECRWIDCYAVFPDQESLVHHIEKSHVELRKAED-FSCFWQGCPRRSRPFNARYKLLIHMRVHSGEKPNKCPFEGCTKAFSRLENLKIHQRSHTGERPYSCQYSGCTKAFSNSSDRAKHQRTHVDTKPYACQVEGCSKRYTDPSSLRKHVKNH 260

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BLAST of GLI-3 vs. TrEMBL
Match: A0A4W5Q2D9 (GLIS family zinc finger 3 OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 259.225 bits (661), Expect = 1.883e-75
Identity = 117/166 (70.48%), Postives = 132/166 (79.52%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNL 1191
            C W+DC   +   + LV HIEK+HVDQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH+RSHTGE+PYQCQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GCGKRYTDPSSLRKH KSH + + QL   +   L
Sbjct:  252 CRWVDCSAVYDQKEELVRHIEKLHVDQRKGED-FTCFWAGCPRRFKPFNARYKLLIHMRVHSGEKPNKCTFEGCQKAFSRLENLKIHQRSHTGEKPYQCQHPGCHKAFSNSSDRAKHQRTHLDTKPYACQIPGCGKRYTDPSSLRKHVKSHSSKERQLRKKVSMEL 416

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BLAST of GLI-3 vs. TrEMBL
Match: A0A4Y2HFV3 (Zinc finger protein GLIS3 OS=Araneus ventricosus OX=182803 GN=Glis3 PE=4 SV=1)

HSP 1 Score: 260.381 bits (664), Expect = 7.313e-75
Identity = 118/161 (73.29%), Postives = 130/161 (80.75%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLN 1170
             +C+W+DC   F    SLV HIEK HVDQR  +++++C W GC RKL+PFNARYKLLIHMRVHSGEKPNKC + GCDKAFSRLENLKIH RSHTGERPY CQYIGCPKAFSNSSDRAKHQRTH D+KPY C   GC KRYTDPSSLRKH K+H     QLN
Sbjct:  345 FVCYWVDCKTVFQSQSSLVRHIEKFHVDQRK-REDFSCLWVGCPRKLRPFNARYKLLIHMRVHSGEKPNKCMFLGCDKAFSRLENLKIHFRSHTGERPYHCQYIGCPKAFSNSSDRAKHQRTHQDSKPYYCQEPGCNKRYTDPSSLRKHVKNHVLRMEQLN 504

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BLAST of GLI-3 vs. Ensembl Cavefish
Match: glis3 (GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-070112-2232])

HSP 1 Score: 244.588 bits (623), Expect = 5.031e-73
Identity = 111/157 (70.70%), Postives = 126/157 (80.25%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            C W+DC  ++   + LV HIEK+H+DQR  +D +TC+W GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH KSH   + Q
Sbjct:  306 CRWLDCNATYSHKEELVKHIEKLHMDQRKGED-FTCYWAGCPRRHKPFNARYKLLIHMRVHSGEKPNKCTFEGCQKAFSRLENLKIHLRSHTGEKPYTCQHPGCQKAFSNSSDRAKHQRTHIDTKPYACQIQGCLKRYTDPSSLRKHVKSHSTKEQQ 461

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BLAST of GLI-3 vs. Ensembl Cavefish
Match: glis3 (GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-070112-2232])

HSP 1 Score: 246.514 bits (628), Expect = 2.760e-72
Identity = 111/157 (70.70%), Postives = 126/157 (80.25%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            C W+DC  ++   + LV HIEK+H+DQR  +D +TC+W GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C + GC KRYTDPSSLRKH KSH   + Q
Sbjct:  451 CRWLDCNATYSHKEELVKHIEKLHMDQRKGED-FTCYWAGCPRRHKPFNARYKLLIHMRVHSGEKPNKCTFEGCQKAFSRLENLKIHLRSHTGEKPYTCQHPGCQKAFSNSSDRAKHQRTHIDTKPYACQIQGCLKRYTDPSSLRKHVKSHSTKEQQ 606

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BLAST of GLI-3 vs. Ensembl Cavefish
Match: glis2a (GLIS family zinc finger 2a [Source:ZFIN;Acc:ZDB-GENE-130102-1])

HSP 1 Score: 197.593 bits (501), Expect = 2.885e-56
Identity = 92/166 (55.42%), Postives = 118/166 (71.08%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASID 1182
            +L C W+ C+  F   + LV+H+ + HV        Y C W+GC+RK + FNARYK+LIH+R H+ EKP++C    C K+FSRLENLKIH RSHTGE+PY C Y GC K +SNSSDR KH RTHY+ KPYCC + GC KRYTDPSSLRKH K+H +  +Q + S++
Sbjct:  152 QLACRWLKCHLLFECLQDLVDHVTEFHVKPER-STGYCCHWEGCARKGRGFNARYKMLIHIRTHTNEKPHQCAI--CSKSFSRLENLKIHTRSHTGEKPYVCPYEGCGKRYSNSSDRFKHTRTHYEDKPYCCKMVGCHKRYTDPSSLRKHIKAHGHSVAQESRSME 314

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BLAST of GLI-3 vs. Ensembl Cavefish
Match: glis2b (GLIS family zinc finger 2 [Source:NCBI gene;Acc:103031738])

HSP 1 Score: 195.282 bits (495), Expect = 6.357e-55
Identity = 99/193 (51.30%), Postives = 125/193 (64.77%), Query Frame = 1

Query:  610 INIHQFSNCNLSNQIYT--SIDSRPHP------KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQ 1164
            + I   S  +L + +++  S D R  P      +L C W  C+  F   + LV+H+   HV        Y C W+GC+RK + FNARYK+LIH+R H+ EKP++C    C+K+FSRLENLKIH RSHTGE+PY C Y GC K +SNSSDR KH RTHY  KPY C + GC KRYTDPSSLRKH K+H +F SQ
Sbjct:  124 VPIGGGSGLHLPSSMFSGQSKDKRASPDLSADEQLYCRWRKCHLLFDSLQDLVDHVNDFHVKPEK-DSGYCCHWEGCARKGRGFNARYKMLIHIRTHTNEKPHRCPT--CNKSFSRLENLKIHNRSHTGEKPYICPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMVGCLKRYTDPSSLRKHIKAHGHFVSQ 313

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BLAST of GLI-3 vs. Ensembl Cavefish
Match: gli1 (GLI family zinc finger 1 [Source:ZFIN;Acc:ZDB-GENE-030321-1])

HSP 1 Score: 201.06 bits (510), Expect = 3.447e-54
Identity = 91/164 (55.49%), Postives = 117/164 (71.34%), Query Frame = 1

Query:  667 DSRPHPKLI----CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            + +P P+ I    C W  C + F   + LV+HI   H+     K E+ C W+ CSR+ +PF A+Y L++HMR H+GEKP+KC + GC+KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C + GC KRYTDPSSLRKH K+
Sbjct:  312 EEKPEPEAIYETNCHWESCSKEFDTQEQLVHHINNEHI--HGEKKEFVCHWKDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKT 473

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BLAST of GLI-3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008614.1 (pep scaffold:Pmarinus_7.0:GL479003:10005:19084:-1 gene:ENSPMAG00000007806.1 transcript:ENSPMAT00000008614.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 174.481 bits (441), Expect = 3.434e-52
Identity = 81/130 (62.31%), Postives = 102/130 (78.46%), Query Frame = 1

Query:  763 HVDQRNI---KDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTK 1140
            H++  +I   + E+ C W+ CSR+ KPF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGE+PY C++ GC KAFSN+SDRAKHQ RTH + KPY C ++GC KRYTDPSSLRKH K
Sbjct:    1 HINNEHIHGERKEFVCRWRDCSREKKPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKISGCTKRYTDPSSLRKHVK 130

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BLAST of GLI-3 vs. Ensembl Sea Lamprey
Match: glis2b (GLIS family zinc finger 2b [Source:ZFIN;Acc:ZDB-GENE-091204-120])

HSP 1 Score: 174.481 bits (441), Expect = 3.122e-51
Identity = 86/146 (58.90%), Postives = 104/146 (71.23%), Query Frame = 1

Query:  709 CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            C Q F   + LV H+   HV + + +  Y C W+GC+R  + FNARYK+LIH+R H+ EKP++C    C+K+FSRLENLKIH RSHTGE+PY C Y GC K +SNSSDR KH RTHY  KPY C   GC KRYTDPSSLRKH K+H
Sbjct:    3 CQQVFDSQQELVEHVHDAHV-RADREVGYCCHWEGCARMGRGFNARYKMLIHVRTHTNEKPHQCPI--CNKSFSRLENLKIHGRSHTGEKPYACPYQGCSKRYSNSSDRFKHTRTHYVDKPYACKTPGCLKRYTDPSSLRKHVKAH 145

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BLAST of GLI-3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003451.1 (pep scaffold:Pmarinus_7.0:GL477543:42884:56609:1 gene:ENSPMAG00000003158.1 transcript:ENSPMAT00000003451.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 170.244 bits (430), Expect = 2.333e-50
Identity = 88/152 (57.89%), Postives = 103/152 (67.76%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYI-GCPKAFS--NSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTK 1140
            C W +C  +F   + L  HIEK HV+ +   +E+ C W+ C R+ +PFNARYKLLIHMRVHSGEKPN+C  SG  K    L N +   +S T  R   C++  GCPKAFS  NSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH K
Sbjct:    1 CRWEECRAAFGRREQLCRHIEKSHVEPQR-GEEFACQWEACGRRRRPFNARYKLLIHMRVHSGEKPNRCMVSGGSKYHLDLPNWRTRRKSITPSRSAVCRHFEGCPKAFSRLNSSDRAKHQRTHQDTKPYVCQVPGCSKRYTDPSSLRKHVK 151

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BLAST of GLI-3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003448.1 (pep scaffold:Pmarinus_7.0:GL477543:42863:56609:1 gene:ENSPMAG00000003158.1 transcript:ENSPMAT00000003448.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 169.474 bits (428), Expect = 6.487e-50
Identity = 87/151 (57.62%), Postives = 102/151 (67.55%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFS--NSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTK 1140
            C W +C  +F   + L  HIEK HV+ +   +E+ C W+ C R+ +PFNARYKLLIHMRVHSGEKPN+C    C + FS  +  K   R H   +  QC + GCPKAFS  NSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH K
Sbjct:    8 CRWEECRAAFGRREQLCRHIEKSHVEPQR-GEEFACQWEACGRRRRPFNARYKLLIHMRVHSGEKPNRCML--CCETFSHSDTHKHSTRPHQDIKRLQCTFEGCPKAFSRLNSSDRAKHQRTHQDTKPYVCQVPGCSKRYTDPSSLRKHVK 155

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BLAST of GLI-3 vs. Ensembl Sea Lamprey
Match: mtf1 (metal-regulatory transcription factor 1 [Source:ZFIN;Acc:ZDB-GENE-020424-1])

HSP 1 Score: 110.538 bits (275), Expect = 7.981e-26
Identity = 65/178 (36.52%), Postives = 92/178 (51.69%), Query Frame = 1

Query:  688 LICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMF 1221
             +C    C ++F     L ++  K+HV     +  + C   GC    K FN  Y+L  H R+H+G   N C   GC K F+ L +L+ H R+HTGERP+QC++ GC KAFS S     H RTH   +P+ C   GC + ++   SL+ H K H +  S L + I PN   S  S + F
Sbjct:   36 FVCEQTGCGKAF-----LTSYSRKIHVRVHTREKPFECGVSGCE---KSFNTLYRLKAHQRIHTGNTFN-CDSEGCTKFFTTLSDLRKHVRTHTGERPFQCKHSGCGKAFSVSHHLRTHVRTHTGERPFPCPSGGCERAFSSQHSLKSHMKGHPSGAS-LKSEI-PNKNTSRDSQNAF 202

HSP 2 Score: 81.6481 bits (200), Expect = 1.532e-16
Identity = 44/118 (37.29%), Postives = 61/118 (51.69%), Query Frame = 1

Query:  793 YTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            Y C ++GC R    ++    L  H + H GE    C+ +GC KAF    + KIH R HT E+P++C   GC K+F+       HQR H     + C   GC K +T  S LRKH ++H
Sbjct:    6 YQCAYEGCERT---YSTAGNLKTHEKTHRGEYTFVCEQTGCGKAFLTSYSRKIHVRVHTREKPFECGVSGCEKSFNTLYRLKAHQRIHTGNT-FNCDSEGCTKFFTTLSDLRKHVRTH 119

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BLAST of GLI-3 vs. Ensembl Yeast
Match: ZAP1 (Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [Source:SGD;Acc:S000003592])

HSP 1 Score: 95.1301 bits (235), Expect = 8.471e-21
Identity = 63/172 (36.63%), Postives = 87/172 (50.58%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSR----------------KLKP---------FNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSL 1125
            ++IC W  C +SF   + L +H+E +H+ +   K EY C W  C R                K KP         F++   L+ H R HSGEKP KC    C+K F+   +LKIH R+HTGE+P QC+  G  K F+ SS+ +KH +TH   K Y C  + C K + D   L
Sbjct:  704 QVICQWDGCNKSFSSAQELNDHLEAVHLTRG--KSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKCHI--CNKKFAISSSLKIHIRTHTGEKPLQCKICG--KRFNESSNLSKHIKTH--QKKYKC--SDCSKSFDDLGKL 865

HSP 2 Score: 84.7297 bits (208), Expect = 1.821e-17
Identity = 53/151 (35.10%), Postives = 72/151 (47.68%), Query Frame = 1

Query:  787 DEYTCFWQGCSRKL------------------------------KPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQ 1149
            ++  C W GC++                                + F  R KL+ H++VHS  KP KCK   C + FS  E L  H R+H+GE+PY+C    C K F+ SS    H RTH   KP  C +  CGKR+ + S+L KH K+HQ
Sbjct:  703 EQVICQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCK--TCKRCFSSEETLVQHTRTHSGEKPYKCHI--CNKKFAISSSLKIHIRTHTGEKPLQCKI--CGKRFNESSNLSKHIKTHQ 847

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BLAST of GLI-3 vs. Ensembl Yeast
Match: AZF1 (Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000005639])

HSP 1 Score: 81.2629 bits (199), Expect = 2.189e-16
Identity = 50/134 (37.31%), Postives = 69/134 (51.49%), Query Frame = 1

Query:  739 LVNHIEKMHVDQ--RNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKH 1134
            LV  +EK    Q  R +K ++ C +  C R    F+    L +H+R H G KP  C Y  C K F++  NL+ HER HTGE+PY C    C K FS   + A H  TH   KP+ C +  C K +T   +++ H
Sbjct:  574 LVGGVEKPKGTQNTRAVK-KHECPY--CHRL---FSQATHLEVHVRSHIGYKPFVCDY--CGKRFTQGGNLRTHERLHTGEKPYSCDI--CDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAH 697

HSP 2 Score: 62.7734 bits (151), Expect = 1.047e-10
Identity = 31/91 (34.07%), Postives = 50/91 (54.95%), Query Frame = 1

Query:  886 KPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQ 1158
            K ++C Y  C + FS+  +L++H RSH G +P+ C Y  C K F+   +   H+R H   KPY C +  C K+++   +L  H  +HQ  +
Sbjct:  591 KKHECPY--CHRLFSQATHLEVHVRSHIGYKPFVCDY--CGKRFTQGGNLRTHERLHTGEKPYSCDI--CDKKFSRKGNLAAHLVTHQKLK 675

[Close]

BLAST of GLI-3 vs. Ensembl Yeast
Match: FZF1 (Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003223])

HSP 1 Score: 66.6254 bits (161), Expect = 1.529e-12
Identity = 36/96 (37.50%), Postives = 52/96 (54.17%), Query Frame = 1

Query:  895 KCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASID 1182
            KC + GC+K ++R   L+ H+ SHT ++PY C   GC K F        H+ TH   KP  C +  C KR+     LR+H  SH+  +S+L + ID
Sbjct:   13 KCSFDGCEKVYNRPSLLQQHQNSHTNQKPYHCDEPGCGKKFIRPCHLRVHKWTHSQIKPKACTL--CQKRFVTNQQLRRHLNSHER-KSKLASRID 105

HSP 2 Score: 53.9138 bits (128), Expect = 2.358e-8
Identity = 39/144 (27.08%), Postives = 63/144 (43.75%), Query Frame = 1

Query:  967 TGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNKLTKPADFPLLNIQNNITNKVNG 1398
            T  R Y+C + GC K ++  S   +HQ +H + KPY C   GCGK++  P  LR H  +H        + I P      K+ ++   + VT++Q+               R    S  R++KL    D     +  N+  ++NG
Sbjct:    7 TKSRNYKCSFDGCEKVYNRPSLLQQHQNSHTNQKPYHCDEPGCGKKFIRPCHLRVHKWTH--------SQIKP------KACTLCQKRFVTNQQL---------------RRHLNSHERKSKLASRIDRKHEGVNANVKAELNG 121

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BLAST of GLI-3 vs. Ensembl Yeast
Match: CRZ1 (Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium [Source:SGD;Acc:S000004972])

HSP 1 Score: 67.3958 bits (163), Expect = 3.840e-12
Identity = 34/85 (40.00%), Postives = 45/85 (52.94%), Query Frame = 1

Query:  913 CDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVA-------GCGKRYTDPSSLRKHTKSH 1146
            C K F+R  NLK H R+HT ERP+ C    C KAF+   DR +H+  H   K Y CG         GCGK++    +L +H K+ 
Sbjct:  574 CGKKFTRPYNLKSHLRTHTNERPFICSI--CGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTE 656

HSP 2 Score: 52.7582 bits (125), Expect = 1.256e-7
Identity = 36/111 (32.43%), Postives = 53/111 (47.75%), Query Frame = 1

Query:  745 NHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQC-------QYIGCPKAFSNSSDRAKHQRTH 1056
            +++EK+     N K+        C +K   F   Y L  H+R H+ E+P  C  S C KAF+R  + K HE  HTG++ Y C       +  GC K F+ S    +H +T 
Sbjct:  551 DNLEKLDSVTNNRKNPANFACDVCGKK---FTRPYNLKSHLRTHTNERPFIC--SICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTE 656

[Close]

BLAST of GLI-3 vs. Ensembl Yeast
Match: MIG3 (Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genesenvironment [Source:SGD;Acc:S000000830])

HSP 1 Score: 63.5438 bits (153), Expect = 3.184e-11
Identity = 27/58 (46.55%), Postives = 40/58 (68.97%), Query Frame = 1

Query:  883 EKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTH 1056
            ++P +C+   C + F RLE+ K H R+HTGE+P++C   GCPK+FS S +  +H RTH
Sbjct:   14 QRPFRCEI--CSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTH 69

HSP 2 Score: 50.447 bits (119), Expect = 4.242e-7
Identity = 26/60 (43.33%), Postives = 36/60 (60.00%), Query Frame = 1

Query:  862 HMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHT-GERPYQCQYIGCPKAFSNSSDRA 1038
            H R H+GEKP+KC   GC K+FSR + LK H R+HT G +  + +  G  K   N++  A
Sbjct:   35 HGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTHTKGVQRRRIKSKGSRKTVVNTATAA 94

HSP 3 Score: 47.3654 bits (111), Expect = 4.733e-6
Identity = 19/58 (32.76%), Postives = 33/58 (56.90%), Query Frame = 1

Query:  973 ERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            +RP++C+   C + F     + +H RTH   KP+ C V GC K ++    L++H ++H
Sbjct:   14 QRPFRCEI--CSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTH 69

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BLAST of GLI-3 vs. Ensembl Nematostella
Match: EDO45177 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU02])

HSP 1 Score: 234.187 bits (596), Expect = 2.799e-74
Identity = 109/149 (73.15%), Postives = 121/149 (81.21%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTK 1140
            C W+ C   + +   LV HIEK+H+DQR   D Y C+WQ CSR+ KPFNARYKL+IHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GCPKAFSNSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH K
Sbjct:    2 CRWLGCDAVYSEQDDLVRHIEKVHIDQRKADDLYICYWQDCSRQTKPFNARYKLVIHMRVHSGEKPNKCTHPGCNKAFSRLENLKIHMRSHTGEKPYLCQFPGCPKAFSNSSDRAKHQRTHLDTKPYACQVPGCPKRYTDPSSLRKHFK 150

[Close]

BLAST of GLI-3 vs. Ensembl Nematostella
Match: EDO44435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVR5])

HSP 1 Score: 194.897 bits (494), Expect = 6.637e-59
Identity = 92/163 (56.44%), Postives = 113/163 (69.33%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASID 1182
            C W  C   F     LVNH+ + H+   +   EY C WQGC+R  K FNARYK+LIHMR H+GE+P+KC +  C+K+FSRLENLKIH+RSHTGE+PY C   GC K +SNSSDR KH RTHY+ KPY C + GC KRYTDPSSLRKH K++   +S +    D
Sbjct:   19 CKWESCCHHFLTLDDLVNHVNEYHI-TFDKDSEYRCRWQGCNRNGKGFNARYKMLIHMRTHTGERPHKCTFDSCEKSFSRLENLKIHQRSHTGEKPYSCPIEGCDKRYSNSSDRFKHTRTHYERKPYHCRIEGCEKRYTDPSSLRKHLKTYHGQESSIEMDTD 180

[Close]

BLAST of GLI-3 vs. Ensembl Nematostella
Match: EDO37573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFG3])

HSP 1 Score: 190.274 bits (482), Expect = 2.321e-57
Identity = 92/149 (61.74%), Postives = 110/149 (73.83%), Query Frame = 1

Query:  700 WIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            W DC   F    SLV H+   H+ +   K ++TC+WQ CSR+ +PF A+Y L++HMR H+GEKP+KC + GC KA+SRLENLK H RSHTGERPY C+  GC KAFSN+SDRAKHQ RTH   KPY C V GC KRYTDPSSLRKHTK+
Sbjct:    3 WKDCTIVFDSQDSLVKHVNGDHIKKE--KRDFTCYWQDCSREQRPFKAQYMLVVHMRRHTGEKPHKCYHEGCTKAYSRLENLKTHLRSHTGERPYVCEVEGCTKAFSNASDRAKHQNRTHSSVKPYVCKVPGCPKRYTDPSSLRKHTKT 149

[Close]

BLAST of GLI-3 vs. Ensembl Nematostella
Match: NV-ZICD (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK35])

HSP 1 Score: 166.392 bits (420), Expect = 2.887e-48
Identity = 81/165 (49.09%), Postives = 104/165 (63.03%), Query Frame = 1

Query:  688 LICFWID----------CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQN 1152
            L C WID          C + +     +V+HI   HV   N    + C+WQ CSR  +PF A+YKL+ H+RVH+GEKP  C + GC K F+R ENLKIH+R+HTGE+P+ C++ GC + F+NSSDR KH   H   KPY C V GC K YT PSSLRKH K H++
Sbjct:   17 LTCMWIDQGPIPGKRKPCGKQYTHMPDIVSHISDEHVSA-NDSSLHVCYWQECSRNGQPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKLFARSENLKIHKRTHTGEKPFMCEFPGCDRRFANSSDRKKHSHVHTSDKPYICKVDGCNKSYTHPSSLRKHMKLHES 180

[Close]

BLAST of GLI-3 vs. Ensembl Nematostella
Match: NV-ZICA (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8M8])

HSP 1 Score: 162.925 bits (411), Expect = 5.242e-47
Identity = 80/159 (50.31%), Postives = 104/159 (65.41%), Query Frame = 1

Query:  694 CFWIDCYQS--------FHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            C WIDC +         F     LV HI   HV+ R+   ++ C W+ C R  KPF A+YKL+ H+RVH+GEKP  C +S C+K F+R ENLKIH+R+HTGE+P++C++ GC + F+NSSDR KH   H   KPY C  +GC K YT PSSLRKH K+H
Sbjct:   17 CKWIDCTEKVSLLCDKVFSCMDELVKHITIEHVNGRD-STQHVCCWESCDRAGKPFKAKYKLVNHIRVHTGEKPFVCPFSSCNKLFARSENLKIHKRTHTGEKPFECEFKGCNRRFANSSDRKKHSHVHTSDKPYNCRYSGCEKSYTHPSSLRKHLKAH 174

[Close]

BLAST of GLI-3 vs. Ensembl Medaka
Match: glis3 (GLIS family zinc finger 3 [Source:NCBI gene;Acc:100302581])

HSP 1 Score: 252.292 bits (643), Expect = 1.717e-73
Identity = 115/162 (70.99%), Postives = 127/162 (78.40%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASI 1179
            C W+DC   +   + LV HIEK+HVDQR  +D +TC+W GC R LKPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C V GC KRYTDPSSLRKH KSH   + QL   +
Sbjct:  476 CRWMDCSAVYDHKEELVRHIEKLHVDQRKTED-FTCYWVGCPRNLKPFNARYKLLIHMRVHSGEKPNKCSFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCHKAFSNSSDRAKHQRTHLDTKPYACQVPGCAKRYTDPSSLRKHLKSHSTRERQLRKKM 636

[Close]

BLAST of GLI-3 vs. Ensembl Medaka
Match: s2012 (GLIS family zinc finger 1-like [Source:NCBI gene;Acc:100302580])

HSP 1 Score: 253.832 bits (647), Expect = 3.427e-73
Identity = 115/170 (67.65%), Postives = 134/170 (78.82%), Query Frame = 1

Query:  676 PHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDP 1185
            P  K +C WIDC  ++   + LV HIEK+H+DQR  +D +TCFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC+KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DTKPY C ++GC KRYTDPSSLRKH K H   + Q++  + P
Sbjct:  523 PAEKQVCRWIDCSAAYEQQEELVRHIEKVHIDQRKGED-FTCFWAGCIRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCNKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQISGCTKRYTDPSSLRKHVKIHSAKEQQVHRKLRP 691

[Close]

BLAST of GLI-3 vs. Ensembl Medaka
Match: s935 (glis1a [Source:NCBI gene;Acc:100304462])

HSP 1 Score: 200.29 bits (508), Expect = 3.483e-57
Identity = 90/124 (72.58%), Postives = 101/124 (81.45%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDT 1065
            C WIDC  ++   + LV HIEK+H+DQR   +E+ CFW GC R+ KPFNARYKLLIHMRVHSGEKPNKC + GC KAFSRLENLKIH RSHTGE+PY CQ+ GC KAFSNSSDRAKHQRTH DT
Sbjct:  226 CHWIDCSAAYSSQEELVRHIEKVHIDQRK-GEEFACFWAGCVRRHKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYICQHPGCLKAFSNSSDRAKHQRTHLDT 348

[Close]

BLAST of GLI-3 vs. Ensembl Medaka
Match: glis2b (GLIS family zinc finger 2 [Source:NCBI gene;Acc:100304463])

HSP 1 Score: 195.667 bits (496), Expect = 3.199e-55
Identity = 94/165 (56.97%), Postives = 116/165 (70.30%), Query Frame = 1

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDE-YTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNAS 1176
            +L C W  C+  F   + LV+H+   HV     KD  Y C W+GC+RK + FNARYK+LIH+R H+ EKP++C    C+K+FSRLENLKIH RSHTGE+PY C Y GC K +SNSSDR KH RTHY  KPY C + GC KRYTDPSSLRKH K+H +F +Q  A+
Sbjct:  142 QLACRWKKCHLLFDSLQDLVDHVNDFHVKPE--KDSGYCCHWEGCARKGRGFNARYKMLIHIRTHTNEKPHRCPT--CNKSFSRLENLKIHNRSHTGEKPYICPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMVGCLKRYTDPSSLRKHIKAHGHFVAQEQAA 302

[Close]

Query:  685 KLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDE-YTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNAS 1176
            +L C W  C+  F   + LV+H+   HV     KD  Y C W+GC+RK + FNARYK+LIH+R H+ EKP++C    C+K+FSRLENLKIH RSHTGE+PY C Y GC K +SNSSDR KH RTHY  KPY C + GC KRYTDPSSLRKH K+H +F +Q  A+
Sbjct:  142 QLACRWKKCHLLFDSLQDLVDHVNDFHVKPE--KDSGYCCHWEGCARKGRGFNARYKMLIHIRTHTNEKPHRCPT--CNKSFSRLENLKIHNRSHTGEKPYICPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMVGCLKRYTDPSSLRKHIKAHGHFVAQEQAA 302

[Close]

BLAST of GLI-3 vs. Planmine SMEST
Match: SMESG000078300.1 (SMESG000078300.1)

HSP 1 Score: 1135.17 bits (2935), Expect = 0.000e+0
Identity = 573/574 (99.83%), Postives = 574/574 (100.00%), Query Frame = 1

Query:   58 KSKADKRIERLSTWSSIQFGTXXXXXXXXXXXXXXXXXXXXXXXXIDGIDLASLIRVSPNSLNTLYQEFFNYSPDMASILLNSSTSNRSVDPDYFAKSSISTSPPAKIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTSMQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL 1779
            KSKADKRIERLSTWSSIQFGTLSVSSKTSSKKSSTYKSLSISPISIDGIDLASLIRVSPNSLNTLYQEFFNYSPDMASILLNSSTSNRSVDPDYFAKSSISTSPPAKIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTS+QTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL
Sbjct:  177 KSKADKRIERLSTWSSIQFGTLSVSSKTSSKKSSTYKSLSISPISIDGIDLASLIRVSPNSLNTLYQEFFNYSPDMASILLNSSTSNRSVDPDYFAKSSISTSPPAKIPRQSLGHCFTGEQQKLKSSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHSYSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNKLTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVIPENRNVFKQTSIQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQPVQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL 750

[Close]

BLAST of GLI-3 vs. Planmine SMEST
Match: SMESG000060276.1 (SMESG000060276.1)

HSP 1 Score: 189.504 bits (480), Expect = 3.284e-54
Identity = 89/151 (58.94%), Postives = 109/151 (72.19%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 1143
            C W  C +   DC++LVNHI   H+ +   K  Y C W  C R  KPF A+Y L++HMR H+GEKP+KC+YS CDK +SRLENLK H R+HTGE+PY C+++ C K FSN+SDRAKHQ RTH + KPY C V GC KRYTDPSSLRKH K+
Sbjct:   17 CHWESCTKQCFDCETLVNHIFTKHISECK-KPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 166

[Close]

BLAST of GLI-3 vs. Planmine SMEST
Match: SMESG000073727.1 (SMESG000073727.1)

HSP 1 Score: 194.126 bits (492), Expect = 1.919e-52
Identity = 88/168 (52.38%), Postives = 114/168 (67.86%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLW 1194
            C W DC ++F     LV HI  +H+     K  + C W+ C R  +PF A+Y L++HMR H+GEKP++C +  C+K +SRLENLK H RSHTGE+PY+C++ GC KAFSN+SDRAKHQ RTH +TKPY C V GC KRYTDPSSLRKH K++   Q   +  +    W
Sbjct:  303 CHWNDCVKTFDTQAELVKHISTIHISGSG-KQTFVCQWKDCVRSGRPFKAQYMLVVHMRRHTGEKPHQCTFPNCNKRYSRLENLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVEGCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESW 469

[Close]

BLAST of GLI-3 vs. Planmine SMEST
Match: SMESG000073727.1 (SMESG000073727.1)

HSP 1 Score: 193.741 bits (491), Expect = 2.700e-52
Identity = 88/168 (52.38%), Postives = 114/168 (67.86%), Query Frame = 1

Query:  694 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASIDPNLW 1194
            C W DC ++F     LV HI  +H+     K  + C W+ C R  +PF A+Y L++HMR H+GEKP++C +  C+K +SRLENLK H RSHTGE+PY+C++ GC KAFSN+SDRAKHQ RTH +TKPY C V GC KRYTDPSSLRKH K++   Q   +  +    W
Sbjct:  325 CHWNDCVKTFDTQAELVKHISTIHISGSG-KQTFVCQWKDCVRSGRPFKAQYMLVVHMRRHTGEKPHQCTFPNCNKRYSRLENLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVEGCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESW 491

[Close]

BLAST of GLI-3 vs. Planmine SMEST
Match: SMESG000052644.1 (SMESG000052644.1)

HSP 1 Score: 170.244 bits (430), Expect = 3.635e-46
Identity = 84/192 (43.75%), Postives = 113/192 (58.85%), Query Frame = 1

Query:  598 YSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWID---------CYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSH 1146
            YS Q   +QF + N  +   T           C W+D         C + F+    +VNH+   HV      D +TC+W+ C+R  KPF A+YKL+ H+RVH+GEKP +C +  C K F+R ENLKIH+R+HTGE+P++C + GC + F+NSSDR KH   H + KPY C   GC K YT PSSLRKH + H
Sbjct:  157 YSHQAAFYQFFHRNAVSGFRTEFQ--------CLWLDKHMKEERRTCGKLFYTINEIVNHLTLDHVGGPEQLD-HTCYWKNCTRDFKPFKAKYKLVNHLRVHTGEKPFQCPFLSCGKLFARSENLKIHKRTHTGEKPFKCDFEGCDRRFANSSDRKKHMHVHMNDKPYFCKQEGCDKSYTHPSSLRKHMRIH 339

The following BLAST results are available for this feature:

BLAST of GLI-3 vs. Ensembl Human
BLAST of GLI-3 vs. Ensembl Celegans
BLAST of GLI-3 vs. Ensembl Fly
BLAST of GLI-3 vs. Ensembl Zebrafish
BLAST of GLI-3 vs. Ensembl Xenopus
BLAST of GLI-3 vs. Ensembl Mouse
BLAST of GLI-3 vs. UniProt/SwissProt
BLAST of GLI-3 vs. TrEMBL
BLAST of GLI-3 vs. Ensembl Cavefish
BLAST of GLI-3 vs. Ensembl Sea Lamprey
BLAST of GLI-3 vs. Ensembl Yeast
BLAST of GLI-3 vs. Ensembl Nematostella
BLAST of GLI-3 vs. Ensembl Medaka
BLAST of GLI-3 vs. Planmine SMEST

BLAST of GLI-3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GLIS3	3.626e-73	70.63	GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:...	[more]
GLIS1	4.951e-73	68.26	GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:...	[more]
GLIS3	1.769e-72	70.63	GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:...	[more]
GLIS1	7.063e-72	68.26	GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:...	[more]
GLI2	3.494e-54	58.94	GLI family zinc finger 2 [Source:HGNC Symbol;Acc:H...	[more]

BLAST of GLI-3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tra-1	4.903e-50	48.66	Sex-determining transformer protein 1 [Source:Uni...	[more]
ref-2	4.635e-43	42.58	REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:...	[more]
ref-2	6.619e-43	42.58	REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:...	[more]
ref-2	6.619e-43	42.58	REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:...	[more]
ztf-14	3.229e-32	44.37	Zinc finger putative Transcription Factor family ...	[more]

BLAST of GLI-3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lmd	2.430e-70	70.99	gene:FBgn0039039 transcript:FBtr0084364	[more]
ci	8.264e-52	59.60	gene:FBgn0004859 transcript:FBtr0306168	[more]
ci	1.016e-51	59.60	gene:FBgn0004859 transcript:FBtr0089178	[more]
sug	1.410e-50	54.61	gene:FBgn0033782 transcript:FBtr0331985	[more]
sug	3.899e-50	53.55	gene:FBgn0033782 transcript:FBtr0087789	[more]

BLAST of GLI-3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
glis1b	5.956e-77	69.75	GLIS family zinc finger 1b [Source:ZFIN;Acc:ZDB-GE...	[more]
glis1b	2.935e-73	68.48	GLIS family zinc finger 1b [Source:ZFIN;Acc:ZDB-GE...	[more]
glis1a	4.605e-72	72.85	GLIS family zinc finger 1a [Source:ZFIN;Acc:ZDB-GE...	[more]
glis3	7.750e-72	74.17	GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GEN...	[more]
glis3	8.797e-72	74.17	GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of GLI-3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GLIS3	1.361e-73	57.75	GLIS family zinc finger 3 [Source:NCBI gene;Acc:10...	[more]
GLIS3	2.262e-73	57.75	GLIS family zinc finger 3 [Source:NCBI gene;Acc:10...	[more]
GLIS3	1.193e-72	57.75	GLIS family zinc finger 3 [Source:NCBI gene;Acc:10...	[more]
GLI1	8.530e-55	56.10	GLI family zinc finger 1 [Source:NCBI gene;Acc:100...	[more]
GLI1	1.313e-54	56.10	GLI family zinc finger 1 [Source:NCBI gene;Acc:100...	[more]

BLAST of GLI-3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Glis1	8.228e-74	67.46	GLIS family zinc finger 1 [Source:MGI Symbol;Acc:M...	[more]
Glis3	1.032e-73	70.63	GLIS family zinc finger 3 [Source:MGI Symbol;Acc:M...	[more]
Glis1	1.501e-72	67.46	GLIS family zinc finger 1 [Source:MGI Symbol;Acc:M...	[more]
Glis3	2.698e-72	70.63	GLIS family zinc finger 3 [Source:MGI Symbol;Acc:M...	[more]
Gli2	1.202e-54	58.94	GLI-Kruppel family member GLI2 [Source:MGI Symbol;...	[more]

BLAST of GLI-3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8NEA6\|GLIS3_HUMAN	1.741e-72	70.63	Zinc finger protein GLIS3 OS=Homo sapiens OX=9606 ...	[more]
sp\|Q8NBF1\|GLIS1_HUMAN	2.378e-72	68.26	Zinc finger protein GLIS1 OS=Homo sapiens OX=9606 ...	[more]
sp\|Q6XP49\|GLIS3_MOUSE	3.631e-72	70.63	Zinc finger protein GLIS3 OS=Mus musculus OX=10090...	[more]
sp\|Q8K1M4\|GLIS1_MOUSE	1.050e-71	67.46	Zinc finger protein GLIS1 OS=Mus musculus OX=10090...	[more]
sp\|Q91690\|GLI1_XENLA	7.735e-54	56.10	Zinc finger protein GLI1 (Fragment) OS=Xenopus lae...	[more]

BLAST of GLI-3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
D2ILS5	0.000e+0	99.40	GLI-3 OS=Schmidtea mediterranea OX=79327 GN=gli-3 ...	[more]
X1YV67	7.449e-77	75.66	Uncharacterized protein OS=Capitella teleta OX=283...	[more]
A0A2J7PWE6	6.600e-76	76.47	Uncharacterized protein OS=Cryptotermes secundus O...	[more]
A0A4W5Q2D9	1.883e-75	70.48	GLIS family zinc finger 3 OS=Hucho hucho OX=62062 ...	[more]
A0A4Y2HFV3	7.313e-75	73.29	Zinc finger protein GLIS3 OS=Araneus ventricosus O...	[more]

BLAST of GLI-3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
glis3	5.031e-73	70.70	GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GEN...	[more]
glis3	2.760e-72	70.70	GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GEN...	[more]
glis2a	2.885e-56	55.42	GLIS family zinc finger 2a [Source:ZFIN;Acc:ZDB-GE...	[more]
glis2b	6.357e-55	51.30	GLIS family zinc finger 2 [Source:NCBI gene;Acc:10...	[more]
gli1	3.447e-54	55.49	GLI family zinc finger 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]

BLAST of GLI-3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000008614.1	3.434e-52	62.31	pep scaffold:Pmarinus_7.0:GL479003:10005:19084:-1 ...	[more]
glis2b	3.122e-51	58.90	GLIS family zinc finger 2b [Source:ZFIN;Acc:ZDB-GE...	[more]
ENSPMAT00000003451.1	2.333e-50	57.89	pep scaffold:Pmarinus_7.0:GL477543:42884:56609:1 g...	[more]
ENSPMAT00000003448.1	6.487e-50	57.62	pep scaffold:Pmarinus_7.0:GL477543:42863:56609:1 g...	[more]
mtf1	7.981e-26	36.52	metal-regulatory transcription factor 1 [Source:ZF...	[more]

BLAST of GLI-3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
ZAP1	8.471e-21	36.63	Zinc-regulated transcription factor; binds to zinc...	[more]
AZF1	2.189e-16	37.31	Zinc-finger transcription factor; involved in diau...	[more]
FZF1	1.529e-12	37.50	Transcription factor involved in sulfite metabolis...	[more]
CRZ1	3.840e-12	40.00	Transcription factor, activates transcription of s...	[more]
MIG3	3.184e-11	46.55	Transcriptional regulator; partially nonfunctional...	[more]

BLAST of GLI-3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO45177	2.799e-74	73.15	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44435	6.637e-59	56.44	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37573	2.321e-57	61.74	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
NV-ZICD	2.887e-48	49.09	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
NV-ZICA	5.242e-47	50.31	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of GLI-3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
glis3	1.717e-73	70.99	GLIS family zinc finger 3 [Source:NCBI gene;Acc:10...	[more]
s2012	3.427e-73	67.65	GLIS family zinc finger 1-like [Source:NCBI gene;A...	[more]
s935	3.483e-57	72.58	glis1a [Source:NCBI gene;Acc:100304462]	[more]
glis2b	3.199e-55	56.97	GLIS family zinc finger 2 [Source:NCBI gene;Acc:10...	[more]
glis2b	3.199e-55	56.97	GLIS family zinc finger 2 [Source:NCBI gene;Acc:10...	[more]

BLAST of GLI-3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000078300.1	0.000e+0	99.83	SMESG000078300.1	[more]
SMESG000060276.1	3.284e-54	58.94	SMESG000060276.1	[more]
SMESG000073727.1	1.919e-52	52.38	SMESG000073727.1	[more]
SMESG000073727.1	2.700e-52	52.38	SMESG000073727.1	[more]
SMESG000052644.1	3.635e-46	43.75	SMESG000052644.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30000146
GenBank	ACZ64516.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30000146 ID=SMED30000146|Name=GLI-3|organism=Schmidtea mediterranea sexual|type=transcript|length=1892bp
AGGTGACTCCATATTTTCTGTGTTTTGTTTAGGAAAGACAATTATCATAA
TTTGTAGAAATCTAAAGCCGATAAAAGGATCGAAAGATTAAGCACTTGGT
CATCAATTCAATTTGGAACTTTATCTGTCAGTAGTAAAACTTCATCAAAA
AAAAGTTCAACATATAAATCTCTTTCGATAAGTCCGATTTCAATTGACGG
AATTGATCTGGCGAGTCTCATAAGAGTGTCTCCAAACTCATTAAATACTC
TTTATCAGGAATTTTTTAATTATTCTCCAGATATGGCTTCTATTTTATTA
AATTCTTCAACATCCAATAGATCGGTGGATCCAGATTATTTTGCTAAGAG
TTCAATTTCTACTTCTCCACCGGCAAAAATACCTCGTCAAAGTCTGGGTC
ATTGCTTTACTGGTGAACAGCAGAAACTAAAATCATCAGCTCTTGCAAAT
AATTTATATGTTACCCAAATAAAAGATGGTAACAAAATTTCACCATTATC
CATTAATAGCACCTACTCAAACGATTCGGGAATTCACTTGAATCGCTGTA
AAGATGCTTTGACTAATGACTTTGTTCATTCATATTCTGGTGATTATTAC
TCCCCACAAATTAATATCCACCAATTTTCCAATTGTAACTTGTCCAACCA
AATCTACACATCCATAGATTCAAGACCTCATCCAAAATTGATATGCTTTT
GGATAGATTGCTATCAATCTTTCCATGACTGTAAAAGCCTAGTAAATCAT
ATTGAAAAGATGCATGTTGACCAAAGAAATATTAAAGATGAGTACACGTG
TTTTTGGCAAGGTTGTAGTAGAAAACTGAAGCCATTTAATGCCCGCTATA
AACTTTTGATTCATATGCGAGTTCACAGTGGAGAGAAACCAAACAAGTGC
AAATATTCTGGTTGTGATAAAGCCTTTTCAAGATTAGAAAATTTAAAAAT
CCACGAGAGATCACACACTGGAGAACGTCCGTATCAGTGCCAATATATTG
GCTGTCCCAAAGCATTTTCAAATAGTTCTGACAGAGCGAAACATCAAAGA
ACTCATTATGATACGAAACCATATTGCTGCGGAGTTGCTGGTTGCGGCAA
ACGTTATACCGATCCAAGTTCTTTAAGAAAACATACAAAATCCCATCAAA
ATTTTCAGTCTCAACTTAATGCTTCAATAGATCCTAACTTATGGTATTCT
GAAAAATCCCCTTCTATGTTTGACCATAAGATTGTAACTGACAAGCAAAT
GTTACCTCCTCTCAAATGTGGTTCGATTATTAATGGTTTTCCTCAGAGAC
CGACTTATGTATCAAGAAGGAGACAAAATAAACTTACAAAGCCAGCAGAT
TTTCCATTATTAAATATTCAAAACAATATTACAAATAAAGTGAATGGATG
TGTAAATTTTCATAACCAATATCATATGGATCAAAATGGTCATTATCCGC
AATTAGAATCCTTCAATGTATATAATGTCATTCCTGAAAATAGAAATGTA
TTTAAACAAACTTCCATGCAAACTTCACCAATTAATCCAGCATGTCAATA
TAAGCAAACAATATCATCGAATCCGTATTATTTGCCCCAAAATCAAACTT
CCATTAGTATTCCATTTCAAAATCCCCAGCCAGTTCAGATTCAAAATGAT
AAAACTTACAGTTGTAATTATGCAATTGACAACAATCAACTATATGCTGT
TTCACTAAGTGGAAATTCAATTATGGAAAACGGTTATGATAATCAGACTT
CTCAAATCAGCTCTTGGATGCAAAACTTGTAAAGAAATTCATTCAGTATT
TTATGTTTTTGTGACATTTGGTAACTCCAGAACATATAATGTTTTTATTT
TTCCGTGAATCCTAATATCTCCTAATTTTAACTCATTTCAGG

protein sequence of SMED30000146-orf-1

>SMED30000146-orf-1 ID=SMED30000146-orf-1|Name=SMED30000146-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=500bp
MASILLNSSTSNRSVDPDYFAKSSISTSPPAKIPRQSLGHCFTGEQQKLK
SSALANNLYVTQIKDGNKISPLSINSTYSNDSGIHLNRCKDALTNDFVHS
YSGDYYSPQINIHQFSNCNLSNQIYTSIDSRPHPKLICFWIDCYQSFHDC
KSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSG
EKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSD
RAKHQRTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKSHQNFQSQLNASID
PNLWYSEKSPSMFDHKIVTDKQMLPPLKCGSIINGFPQRPTYVSRRRQNK
LTKPADFPLLNIQNNITNKVNGCVNFHNQYHMDQNGHYPQLESFNVYNVI
PENRNVFKQTSMQTSPINPACQYKQTISSNPYYLPQNQTSISIPFQNPQP
VQIQNDKTYSCNYAIDNNQLYAVSLSGNSIMENGYDNQTSQISSWMQNL*

Aliases

The feature 'GLI-3' has the following synonyms


Synonym
GLI-3

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia

Vocabulary: **INTERPRO**
Term	Definition
IPR036236	Znf_C2H2_sf
IPR015880	Znf_C2H2-like
IPR013087	Znf_C2H2_type
IPR007087	Znf_C2H2

Vocabulary: **molecular function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR013087	Zinc finger C2H2-type	SMART	SM00355	c2h2final6	coord: 204..228 e-value: 0.0054 score: 25.9 coord: 136..161 e-value: 5.9 score: 15.3 coord: 264..288 e-value: 0.0038 score: 26.5 coord: 171..198 e-value: 0.47 score: 19.5 coord: 234..258 e-value: 0.0021 score: 27.3
IPR013087	Zinc finger C2H2-type	PFAM	PF00096	zf-C2H2	coord: 205..228 e-value: 7.2E-4 score: 19.9 coord: 234..258 e-value: 3.2E-4 score: 21.0 coord: 264..288 e-value: 3.6E-4 score: 20.8
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 236..258
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 138..161
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 206..228
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 266..288
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 204..233 score: 14.711
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 264..293 score: 10.803
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 176..203 score: 10.367
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 234..263 score: 13.256
None	No IPR available	GENE3D	G3DSA:3.30.160.60		coord: 262..289 e-value: 5.5E-10 score: 41.0
None	No IPR available	GENE3D	G3DSA:3.30.160.60		coord: 170..197 e-value: 4.9E-15 score: 57.2
None	No IPR available	GENE3D	G3DSA:3.30.160.60		coord: 198..227 e-value: 2.7E-13 score: 51.7
None	No IPR available	GENE3D	G3DSA:3.30.160.60		coord: 228..261 e-value: 2.4E-11 score: 45.2
None	No IPR available	GENE3D	G3DSA:3.30.160.60		coord: 137..166 e-value: 1.6E-6 score: 29.8
None	No IPR available	PANTHER	PTHR45718:SF7	GLIS FAMILY ZINC FINGER 3	coord: 134..295
None	No IPR available	PANTHER	PTHR45718	FAMILY NOT NAMED	coord: 134..295
IPR036236	Zinc finger C2H2 superfamily	SUPERFAMILY	SSF57667	beta-beta-alpha zinc fingers	coord: 136..165
IPR036236	Zinc finger C2H2 superfamily	SUPERFAMILY	SSF57667	beta-beta-alpha zinc fingers	coord: 228..284
IPR036236	Zinc finger C2H2 superfamily	SUPERFAMILY	SSF57667	beta-beta-alpha zinc fingers	coord: 185..241