Leucine-rich repeat flightless-interacting protein 2

Overview


Name	Leucine-rich repeat flightless-interacting protein 2
Smed ID	SMED30000118
Length (bp)	1950

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Leucine-rich repeat flightless-interacting protein 2 (SMED30000118) t-SNE clustered cells

Violin plots show distribution of expression levels for Leucine-rich repeat flightless-interacting protein 2 (SMED30000118) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Leucine-rich repeat flightless-interacting protein 2 (SMED30000118) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30000118

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30000118	SMESG000041553.1	Contig4772	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30000118	SMESG000041553.1	Contig4772	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30000118	SMESG000041553.1	Contig4772	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30000118	SMESG000041553.1	Contig4772	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30000118	SMESG000068232.1	Contig4772	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30000118	SMESG000068232.1	Contig4772	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30000118	SMESG000068232.1	Contig4772	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30000118	SMESG000068232.1	Contig4772	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
parenchymal cell	SMED30000118	SMESG000041553.1	dd_Smed_v4_5214_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30000118	SMESG000041553.1	dd_Smed_v4_5214_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Match: LRRFIP1 (LRR binding FLII interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:6702])

HSP 1 Score: 74.3294 bits (181), Expect = 3.394e-13
Identity = 44/84 (52.38%), Postives = 58/84 (69.05%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKS 1127
            + K +L  S+Q++TALE +VIRLE QV R+KS AE+ EK E+ELK  KRK QRE R A +K E+L+  N  L K+LEK    +S
Sbjct:  551 DLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRS 634

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Match: LRRFIP2 (LRR binding FLII interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6703])

HSP 1 Score: 73.559 bits (179), Expect = 3.400e-13
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +T LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  311 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 388

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Match: LRRFIP2 (LRR binding FLII interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6703])

HSP 1 Score: 73.559 bits (179), Expect = 3.790e-13
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +T LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  335 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Match: LRRFIP2 (LRR binding FLII interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6703])

HSP 1 Score: 73.559 bits (179), Expect = 3.790e-13
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +T LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  335 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Match: LRRFIP2 (LRR binding FLII interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6703])

HSP 1 Score: 73.559 bits (179), Expect = 4.396e-13
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +T LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  414 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 491

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Celegans
Match: flap-1 (FLi1-Associated Protein homolog [Source:UniProtKB/TrEMBL;Acc:Q8MQ17])

HSP 1 Score: 53.5286 bits (127), Expect = 2.631e-7
Identity = 32/86 (37.21%), Postives = 57/86 (66.28%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKK 1133
            E K ++Q  +++ T  + +VIR+EGQ+KR+KS A+  EK+ +ELK   R+ ++E R+ +N +++ K  N  LQ +LEK   Q++ +
Sbjct:  286 EMKLKMQDLERENTNQQGNVIRMEGQMKRYKSNADVAEKELDELKTQMRQTKKELRDKENALDEQKETNKHLQSRLEKMRMQRTGR 371

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Celegans
Match: flap-1 (FLi1-Associated Protein homolog [Source:UniProtKB/TrEMBL;Acc:Q8MQ17])

HSP 1 Score: 53.5286 bits (127), Expect = 2.728e-7
Identity = 32/86 (37.21%), Postives = 57/86 (66.28%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKK 1133
            E K ++Q  +++ T  + +VIR+EGQ+KR+KS A+  EK+ +ELK   R+ ++E R+ +N +++ K  N  LQ +LEK   Q++ +
Sbjct:  266 EMKLKMQDLERENTNQQGNVIRMEGQMKRYKSNADVAEKELDELKTQMRQTKKELRDKENALDEQKETNKHLQSRLEKMRMQRTGR 351

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Match: BX247888.2 (pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24103430:24111429:1 gene:ENSDARG00000115755.1 transcript:ENSDART00000184057.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX247888.2)

HSP 1 Score: 78.1814 bits (191), Expect = 4.931e-17
Identity = 44/81 (54.32%), Postives = 60/81 (74.07%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            Q  + K +L  S+Q++TALE +V RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:   14 QVNDLKFKLVKSEQEITALEQNVTRLEGQVSRYKAASENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLSKRLEK 94

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Match: lrrfip1a (leucine rich repeat (in FLII) interacting protein 1a [Source:ZFIN;Acc:ZDB-GENE-030131-99])

HSP 1 Score: 77.7962 bits (190), Expect = 1.227e-15
Identity = 44/82 (53.66%), Postives = 60/82 (73.17%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKY 1112
            Q  + K +L  S+Q++TALE +V RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK 
Sbjct:  153 QVNDLKFKLVKSEQEITALEQNVTRLEGQVSRYKAASENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLSKRLEKI 234

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Match: BX247888.2 (pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062529:24111429:1 gene:ENSDARG00000115755.1 transcript:ENSDART00000180693.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX247888.2)

HSP 1 Score: 78.5666 bits (192), Expect = 5.665e-15
Identity = 44/81 (54.32%), Postives = 60/81 (74.07%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            Q  + K +L  S+Q++TALE +V RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:  319 QVNDLKFKLVKSEQEITALEQNVTRLEGQVSRYKAASENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLSKRLEK 399

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Match: BX247888.2 (pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062535:24108781:1 gene:ENSDARG00000115755.1 transcript:ENSDART00000187451.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX247888.2)

HSP 1 Score: 78.1814 bits (191), Expect = 7.799e-15
Identity = 44/82 (53.66%), Postives = 60/82 (73.17%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKY 1112
            Q  + K +L  S+Q++TALE +V RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK 
Sbjct:  355 QVNDLKFKLVKSEQEITALEQNVTRLEGQVSRYKAASENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLSKRLEKI 436

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Match: BX247888.2 (pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062529:24111429:1 gene:ENSDARG00000115755.1 transcript:ENSDART00000190999.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX247888.2)

HSP 1 Score: 78.1814 bits (191), Expect = 9.709e-15
Identity = 44/81 (54.32%), Postives = 60/81 (74.07%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            Q  + K +L  S+Q++TALE +V RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:  381 QVNDLKFKLVKSEQEITALEQNVTRLEGQVSRYKAASENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLSKRLEK 461

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Match: bhmt (betaine--homocysteine S-methyltransferase [Source:Xenbase;Acc:XB-GENE-1008382])

HSP 1 Score: 72.7886 bits (177), Expect = 3.288e-13
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  253 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 330

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Match: bhmt (betaine--homocysteine S-methyltransferase [Source:Xenbase;Acc:XB-GENE-1008382])

HSP 1 Score: 72.7886 bits (177), Expect = 4.964e-13
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  295 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 372

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Match: bhmt (betaine--homocysteine S-methyltransferase [Source:Xenbase;Acc:XB-GENE-1008382])

HSP 1 Score: 72.4034 bits (176), Expect = 5.747e-13
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  309 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 386

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Match: bhmt (betaine--homocysteine S-methyltransferase [Source:Xenbase;Acc:XB-GENE-1008382])

HSP 1 Score: 72.0182 bits (175), Expect = 8.261e-13
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  310 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 387

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Match: bhmt (betaine--homocysteine S-methyltransferase [Source:Xenbase;Acc:XB-GENE-1008382])

HSP 1 Score: 72.4034 bits (176), Expect = 9.196e-13
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  349 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 426

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Match: Lrrfip1 (leucine rich repeat (in FLII) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1342770])

HSP 1 Score: 73.559 bits (179), Expect = 2.362e-13
Identity = 43/84 (51.19%), Postives = 58/84 (69.05%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKS 1127
            + K +L  S+Q++TALE +VIRLE QV R++S AE+ EK E+ELK  KRK QRE R A +K E+L+  N  L K+LEK    +S
Sbjct:  339 DLKFKLAKSEQEITALEQNVIRLESQVTRYRSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRS 422

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Match: Lrrfip2 (leucine rich repeat (in FLII) interacting protein 2 [Source:MGI Symbol;Acc:MGI:1918518])

HSP 1 Score: 72.7886 bits (177), Expect = 2.792e-13
Identity = 40/78 (51.28%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  +RK QRE R AQ+KIE+++  N+ L K+LEK
Sbjct:  284 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEK 361

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Match: Lrrfip2 (leucine rich repeat (in FLII) interacting protein 2 [Source:MGI Symbol;Acc:MGI:1918518])

HSP 1 Score: 73.1738 bits (178), Expect = 3.355e-13
Identity = 40/78 (51.28%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  +RK QRE R AQ+KIE+++  N+ L K+LEK
Sbjct:  348 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEK 425

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Match: Lrrfip2 (leucine rich repeat (in FLII) interacting protein 2 [Source:MGI Symbol;Acc:MGI:1918518])

HSP 1 Score: 72.7886 bits (177), Expect = 3.549e-13
Identity = 40/79 (50.63%), Postives = 56/79 (70.89%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKY 1112
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  +RK QRE R AQ+KIE+++  N+ L K+LEK 
Sbjct:  314 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKM 392

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Match: Lrrfip2 (leucine rich repeat (in FLII) interacting protein 2 [Source:MGI Symbol;Acc:MGI:1918518])

HSP 1 Score: 72.7886 bits (177), Expect = 3.715e-13
Identity = 40/78 (51.28%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  +RK QRE R AQ+KIE+++  N+ L K+LEK
Sbjct:  311 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEK 388

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q6GNW0|LRRF2_XENLA (Leucine-rich repeat flightless-interacting protein 2 OS=Xenopus laevis OX=8355 GN=lrrfip2 PE=2 SV=2)

HSP 1 Score: 75.485 bits (184), Expect = 7.270e-13
Identity = 42/78 (53.85%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  S+Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  640 EYKFRLSKSEQDITTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 717

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q4V7E8|LRRF2_RAT (Leucine-rich repeat flightless-interacting protein 2 OS=Rattus norvegicus OX=10116 GN=Lrrfip2 PE=1 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.561e-12
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R AQ+KIE+++  N+ L K+LEK
Sbjct:  348 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAEKRKLQRELRTAQDKIEEMEMTNSHLAKRLEK 425

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q9Y608|LRRF2_HUMAN (Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 2.707e-12
Identity = 41/78 (52.56%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +T LE  + RLEGQV R+K+ AE+ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 709

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Match: sp|Q91WK0|LRRF2_MOUSE (Leucine-rich repeat flightless-interacting protein 2 OS=Mus musculus OX=10090 GN=Lrrfip2 PE=1 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 2.814e-12
Identity = 40/78 (51.28%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q +  LE  + RLEGQV R+K+ AE+ EK E+ELK  +RK QRE R AQ+KIE+++  N+ L K+LEK
Sbjct:  326 EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEK 403

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Match: sp|B2GUE2|LRRF2_XENTR (Leucine-rich repeat flightless-interacting protein 2 OS=Xenopus tropicalis OX=8364 GN=lrrfip2 PE=2 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 3.262e-12
Identity = 40/78 (51.28%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK ++  ++Q +T LE +V+RLEGQV R+KS AE+ EK E+ELK  KR+ QRE R A +K+E+++  N  L K+LEK
Sbjct:  315 EYKFKISKAEQDMTTLEQNVMRLEGQVVRYKSAAENAEKVEDELKAEKRRLQRELRTALDKMEEMEMTNNHLVKRLEK 392

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Match: A0A095AUT6 (Leucine-rich repeat flightless-interacting protein 2 OS=Schistosoma haematobium OX=6185 GN=MS3_06650 PE=4 SV=1)

HSP 1 Score: 104.76 bits (260), Expect = 4.951e-22
Identity = 50/87 (57.47%), Postives = 72/87 (82.76%), Query Frame = 3

Query:  858 TKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAK 1118
            +++Q QEYK +   S QK++ALE+D++RLEGQ KR+K+IA++CE+QEE LKQ +RK QRE RE Q+K+EDLK+ENA LQ+ ++KY +
Sbjct:   80 SRNQAQEYKLKFHESSQKISALESDIVRLEGQTKRYKAIADACEEQEEILKQDRRKCQRELREVQSKLEDLKAENARLQRVVDKYNR 166

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Match: A0A0R3SWN4 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS10106 PE=4 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 2.109e-21
Identity = 53/95 (55.79%), Postives = 72/95 (75.79%), Query Frame = 3

Query:  855 ATKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 1139
            A +SQ Q+YK +L+ + QK+T LE D+IRLEGQVKR K+IAE+ E QE++LKQ +RK QRE REA + I+DLKSEN TLQ+K++K ++      T
Sbjct:  210 AARSQAQDYKFRLEQANQKITGLEGDIIRLEGQVKRFKTIAENAETQEDQLKQERRKLQRELREALSTIDDLKSENFTLQRKIDKLSRSGPGLPT 304

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Match: A0A0R3TQR6 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS9889 PE=4 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 7.470e-21
Identity = 50/93 (53.76%), Postives = 71/93 (76.34%), Query Frame = 3

Query:  861 KSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 1139
            +SQ Q+YK +L+ + QK++ LE D+IRLEGQVKR K+IAE  E QE++LKQ +RK QRE REA + ++DLKSEN+TLQ+K++K ++      T
Sbjct:  164 RSQAQDYKFRLEQANQKISGLEGDIIRLEGQVKRFKTIAEDAETQEDQLKQERRKLQRELREALSTVDDLKSENSTLQRKIDKLSRGGPGLPT 256

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Match: H2KS12 (Leucine-rich repeat flightless-interacting protein 2 OS=Clonorchis sinensis OX=79923 GN=CLF_107788 PE=4 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 7.759e-21
Identity = 51/83 (61.45%), Postives = 71/83 (85.54%), Query Frame = 3

Query:  861 KSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            +SQ QEYK +LQ + QK  +LE+D++RLEGQ+KR+K+IA+SCE+QE +LKQ +RK+QRE RE Q+++ED KSENA LQ+KL+K
Sbjct:  282 RSQAQEYKYKLQEALQKNASLESDIVRLEGQIKRYKTIADSCEQQEADLKQDRRKFQRELREVQSQLEDYKSENARLQRKLDK 364

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Match: A0A430Q714 (Uncharacterized protein OS=Schistosoma bovis OX=6184 GN=DC041_0004519 PE=4 SV=1)

HSP 1 Score: 105.145 bits (261), Expect = 1.087e-20
Identity = 50/87 (57.47%), Postives = 72/87 (82.76%), Query Frame = 3

Query:  858 TKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAK 1118
            +++Q QEYK +   S QK++ALE+D++RLEGQ KR+K+IA++CE+QEE LKQ +RK QRE RE Q+K+EDLK+ENA LQ+ ++KY +
Sbjct:  255 SRNQAQEYKLKFHESSQKISALESDIVRLEGQTKRYKAIADACEEQEEILKQDRRKCQRELREVQSKLEDLKAENARLQRVVDKYNR 341

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
Match: lrrfip1a (leucine-rich repeat flightless-interacting protein 2-like [Source:NCBI gene;Acc:103029480])

HSP 1 Score: 79.7221 bits (195), Expect = 2.935e-15
Identity = 44/70 (62.86%), Postives = 54/70 (77.14%), Query Frame = 3

Query:  900 SQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            S+Q+VTALE +  RLEGQV R+KS AE+ EK E+ELK  KRK QRE R A +KIE+LKS N+ L K+LEK
Sbjct:  479 SEQEVTALEQNATRLEGQVSRYKSAAENAEKVEDELKAEKRKLQRELRSALDKIEELKSSNSHLTKRLEK 548

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
Match: lrrfip1b (leucine rich repeat (in FLII) interacting protein 1b [Source:ZFIN;Acc:ZDB-GENE-050208-324])

HSP 1 Score: 74.3294 bits (181), Expect = 1.613e-13
Identity = 39/76 (51.32%), Postives = 56/76 (73.68%), Query Frame = 3

Query:  900 SQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKS 1127
            S+Q+V ALE +VIRLEGQV R+K  +E+ EK E++LK  KRK QRE R A ++I++L++ N+ L K+LEK    +S
Sbjct:  432 SEQEVAALEQNVIRLEGQVSRYKGASETAEKVEDDLKVEKRKLQRELRAALDRIDELEASNSHLSKRLEKMKANRS 507

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
Match: lrrfip2 (LRR binding FLII interacting protein 2 [Source:NCBI gene;Acc:103025030])

HSP 1 Score: 70.0922 bits (170), Expect = 2.589e-12
Identity = 39/79 (49.37%), Postives = 57/79 (72.15%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKY 1112
            EYK +L  ++Q++  +E +V RLEGQV R+K+ A++ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK 
Sbjct:  316 EYKFKLSKAEQEMGTMEQNVSRLEGQVSRYKAAADNSEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLVKRLEKM 394

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
Match: lrrfip2 (LRR binding FLII interacting protein 2 [Source:NCBI gene;Acc:103025030])

HSP 1 Score: 70.0922 bits (170), Expect = 2.831e-12
Identity = 39/78 (50.00%), Postives = 57/78 (73.08%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q++  +E +V RLEGQV R+K+ A++ EK E+ELK  KRK QRE R A +KIE+++  N+ L K+LEK
Sbjct:  340 EYKFKLSKAEQEMGTMEQNVSRLEGQVSRYKAAADNSEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLVKRLEK 417

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Sea Lamprey
Match: lrrfip2 (leucine rich repeat (in FLII) interacting protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-7781])

HSP 1 Score: 74.7146 bits (182), Expect = 2.176e-14
Identity = 40/78 (51.28%), Postives = 58/78 (74.36%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            E+K +L  ++Q +TALE  + RLEGQV R+K+ +E+ EK E+ELK  KRK QRE R AQ+++E+L+  N+ L K+LEK
Sbjct:  454 EHKFKLSKAEQDITALEQSIARLEGQVARYKTASENAEKVEDELKAEKRKLQRELRSAQDRVEELEITNSQLTKRLEK 531

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010593.1 (pep scaffold:Pmarinus_7.0:GL477281:1754:14363:1 gene:ENSPMAG00000009592.1 transcript:ENSPMAT00000010593.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.7734 bits (151), Expect = 1.365e-10
Identity = 33/84 (39.29%), Postives = 54/84 (64.29%), Query Frame = 3

Query:  858 TKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            T     EYK +L  S+Q+   LE +++RL+GQ+ RHK+ A+  EK+E+ELK  +R+ QRE   A  K++++++ N  L  +L K
Sbjct:  376 TNKHLSEYKYKLAKSEQEKATLEKNILRLQGQISRHKAAADGAEKEEDELKADRRRLQRELHMALEKLDEMETTNNHLMMRLSK 459

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010594.1 (pep scaffold:Pmarinus_7.0:GL477281:1760:14318:1 gene:ENSPMAG00000009592.1 transcript:ENSPMAT00000010594.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 61.6178 bits (148), Expect = 2.380e-10
Identity = 32/82 (39.02%), Postives = 53/82 (64.63%), Query Frame = 3

Query:  858 TKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKL 1103
            T     EYK +L  S+Q+   LE +++RL+GQ+ RHK+ A+  EK+E+ELK  +R+ QRE   A  K++++++ N  L  +L
Sbjct:  374 TNKHLSEYKYKLAKSEQEKATLEKNILRLQGQISRHKAAADGAEKEEDELKADRRRLQRELHMALEKLDEMETTNNHLMMRL 455

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Match: ENSORLT00000022840.2 (leucine-rich repeat flightless-interacting protein 2 [Source:NCBI gene;Acc:101173988])

HSP 1 Score: 79.7221 bits (195), Expect = 4.033e-15
Identity = 49/91 (53.85%), Postives = 63/91 (69.23%), Query Frame = 3

Query:  843 IMILATKSQGQ--EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            IM L   S  Q  + K +L  ++Q VTALE +V RLEG V R+KS+AE+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:  530 IMDLQRDSSRQINDLKFKLVKAEQDVTALEQNVTRLEGHVTRYKSLAENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLNKRLEK 620

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Match: ENSORLT00000035063.1 (leucine-rich repeat flightless-interacting protein 2 [Source:NCBI gene;Acc:101173988])

HSP 1 Score: 79.7221 bits (195), Expect = 4.644e-15
Identity = 49/91 (53.85%), Postives = 63/91 (69.23%), Query Frame = 3

Query:  843 IMILATKSQGQ--EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            IM L   S  Q  + K +L  ++Q VTALE +V RLEG V R+KS+AE+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:  573 IMDLQRDSSRQINDLKFKLVKAEQDVTALEQNVTRLEGHVTRYKSLAENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLNKRLEK 663

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Match: ENSORLT00000043255.1 (leucine-rich repeat flightless-interacting protein 2 [Source:NCBI gene;Acc:101173988])

HSP 1 Score: 79.337 bits (194), Expect = 5.312e-15
Identity = 49/91 (53.85%), Postives = 63/91 (69.23%), Query Frame = 3

Query:  843 IMILATKSQGQ--EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            IM L   S  Q  + K +L  ++Q VTALE +V RLEG V R+KS+AE+ EK E+ELK  KRK QRE R A +KIE+L+S N+ L K+LEK
Sbjct:  597 IMDLQRDSSRQINDLKFKLVKAEQDVTALEQNVTRLEGHVTRYKSLAENAEKVEDELKAEKRKLQRELRSALDKIEELESSNSHLNKRLEK 687

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Match: ENSORLT00000039655.1 (pep primary_assembly:ASM223467v1:2:25019886:25025427:-1 gene:ENSORLG00000026167.1 transcript:ENSORLT00000039655.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.4774 bits (171), Expect = 1.520e-14
Identity = 41/82 (50.00%), Postives = 58/82 (70.73%), Query Frame = 3

Query:  867 QGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKY 1112
            Q  E K +L  ++Q+VTALE +VIRL+GQV R+K+ +E+ EK E+ LK  KRK QRE R A ++I +L++ N  L K+LEK 
Sbjct:   10 QISELKFKLVKAEQEVTALEQNVIRLDGQVTRYKTASEAAEKIEDSLKVEKRKLQRELRSALDRIGELEAANKHLSKRLEKM 91

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Match: lrrfip2 (LRR binding FLII interacting protein 2 [Source:NCBI gene;Acc:111948791])

HSP 1 Score: 67.3958 bits (163), Expect = 2.063e-11
Identity = 36/78 (46.15%), Postives = 56/78 (71.79%), Query Frame = 3

Query:  876 EYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEK 1109
            EYK +L  ++Q++T +E ++ RLE Q+ R+K  A++ EK E+ELK  KRK QRE R A +K+E+++  N+ L K+LEK
Sbjct:  339 EYKFKLSKAEQEITTMELNITRLEAQMARYKVAADNSEKVEDELKAEKRKLQRELRTALDKLEEMEMTNSHLVKRLEK 416

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Planmine SMEST
Match: SMESG000041553.1 (SMESG000041553.1)

HSP 1 Score: 181.415 bits (459), Expect = 7.473e-51
Identity = 94/95 (98.95%), Postives = 94/95 (98.95%), Query Frame = 3

Query:  855 ATKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 1139
             TKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET
Sbjct:  293 TTKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 387

[Close]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Planmine SMEST
Match: SMESG000041553.1 (SMESG000041553.1)

HSP 1 Score: 174.866 bits (442), Expect = 2.576e-48
Identity = 94/102 (92.16%), Postives = 94/102 (92.16%), Query Frame = 3

Query:  855 ATKSQGQEYKRQLQISQQKVTALEADV-------IRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 1139
             TKSQGQEYKRQLQISQQKVTALEADV       IRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET
Sbjct:  293 TTKSQGQEYKRQLQISQQKVTALEADVKTLENKVIRLEGQVKRHKSIAESCEKQEEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKET 394

The following BLAST results are available for this feature:

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Celegans
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Fly
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Sea Lamprey
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Yeast
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Nematostella
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Planmine SMEST

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
LRRFIP1	3.394e-13	52.38	LRR binding FLII interacting protein 1 [Source:HGN...	[more]
LRRFIP2	3.400e-13	52.56	LRR binding FLII interacting protein 2 [Source:HGN...	[more]
LRRFIP2	3.790e-13	52.56	LRR binding FLII interacting protein 2 [Source:HGN...	[more]
LRRFIP2	3.790e-13	52.56	LRR binding FLII interacting protein 2 [Source:HGN...	[more]
LRRFIP2	4.396e-13	52.56	LRR binding FLII interacting protein 2 [Source:HGN...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
flap-1	2.631e-7	37.21	FLi1-Associated Protein homolog [Source:UniProtKB...	[more]
flap-1	2.728e-7	37.21	FLi1-Associated Protein homolog [Source:UniProtKB...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
BX247888.2	4.931e-17	54.32	pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24103430:2...	[more]
lrrfip1a	1.227e-15	53.66	leucine rich repeat (in FLII) interacting protein ...	[more]
BX247888.2	5.665e-15	54.32	pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062529:2...	[more]
BX247888.2	7.799e-15	53.66	pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062535:2...	[more]
BX247888.2	9.709e-15	54.32	pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:24062529:2...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
bhmt	3.288e-13	51.28	betaine--homocysteine S-methyltransferase [Source:...	[more]
bhmt	4.964e-13	51.28	betaine--homocysteine S-methyltransferase [Source:...	[more]
bhmt	5.747e-13	51.28	betaine--homocysteine S-methyltransferase [Source:...	[more]
bhmt	8.261e-13	51.28	betaine--homocysteine S-methyltransferase [Source:...	[more]
bhmt	9.196e-13	51.28	betaine--homocysteine S-methyltransferase [Source:...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Lrrfip1	2.362e-13	51.19	leucine rich repeat (in FLII) interacting protein ...	[more]
Lrrfip2	2.792e-13	51.28	leucine rich repeat (in FLII) interacting protein ...	[more]
Lrrfip2	3.355e-13	51.28	leucine rich repeat (in FLII) interacting protein ...	[more]
Lrrfip2	3.549e-13	50.63	leucine rich repeat (in FLII) interacting protein ...	[more]
Lrrfip2	3.715e-13	51.28	leucine rich repeat (in FLII) interacting protein ...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6GNW0\|LRRF2_XENLA	7.270e-13	53.85	Leucine-rich repeat flightless-interacting protein...	[more]
sp\|Q4V7E8\|LRRF2_RAT	1.561e-12	52.56	Leucine-rich repeat flightless-interacting protein...	[more]
sp\|Q9Y608\|LRRF2_HUMAN	2.707e-12	52.56	Leucine-rich repeat flightless-interacting protein...	[more]
sp\|Q91WK0\|LRRF2_MOUSE	2.814e-12	51.28	Leucine-rich repeat flightless-interacting protein...	[more]
sp\|B2GUE2\|LRRF2_XENTR	3.262e-12	51.28	Leucine-rich repeat flightless-interacting protein...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A095AUT6	4.951e-22	57.47	Leucine-rich repeat flightless-interacting protein...	[more]
A0A0R3SWN4	2.109e-21	55.79	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]
A0A0R3TQR6	7.470e-21	53.76	Uncharacterized protein OS=Rodentolepis nana OX=10...	[more]
H2KS12	7.759e-21	61.45	Leucine-rich repeat flightless-interacting protein...	[more]
A0A430Q714	1.087e-20	57.47	Uncharacterized protein OS=Schistosoma bovis OX=61...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
lrrfip1a	2.935e-15	62.86	leucine-rich repeat flightless-interacting protein...	[more]
lrrfip1b	1.613e-13	51.32	leucine rich repeat (in FLII) interacting protein ...	[more]
lrrfip2	2.589e-12	49.37	LRR binding FLII interacting protein 2 [Source:NCB...	[more]
lrrfip2	2.831e-12	50.00	LRR binding FLII interacting protein 2 [Source:NCB...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
lrrfip2	2.176e-14	51.28	leucine rich repeat (in FLII) interacting protein ...	[more]
ENSPMAT00000010593.1	1.365e-10	39.29	pep scaffold:Pmarinus_7.0:GL477281:1754:14363:1 ge...	[more]
ENSPMAT00000010594.1	2.380e-10	39.02	pep scaffold:Pmarinus_7.0:GL477281:1760:14318:1 ge...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000022840.2	4.033e-15	53.85	leucine-rich repeat flightless-interacting protein...	[more]
ENSORLT00000035063.1	4.644e-15	53.85	leucine-rich repeat flightless-interacting protein...	[more]
ENSORLT00000043255.1	5.312e-15	53.85	leucine-rich repeat flightless-interacting protein...	[more]
ENSORLT00000039655.1	1.520e-14	50.00	pep primary_assembly:ASM223467v1:2:25019886:250254...	[more]
lrrfip2	2.063e-11	46.15	LRR binding FLII interacting protein 2 [Source:NCB...	[more]

BLAST of Leucine-rich repeat flightless-interacting protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000041553.1	7.473e-51	98.95	SMESG000041553.1	[more]
SMESG000041553.1	2.576e-48	92.16	SMESG000041553.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30000118 ID=SMED30000118|Name=Leucine-rich repeat flightless-interacting protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1950bp
ATCGAATATTTAATCATTGGAATATATTTTTCAAGTTATAGATTATTGTC
ACGATTTCACCCTCCAAAACAATTTCGTAAAATGGTTTTGTGAAATCGTA
TTTATAATCGTGGGCCGCGAAATTATATTATGGCGGTCACATGATGGTTC
GGGTTAGCCACCTTAATTTAAAAAATTACATGCAATGTTTTTAAATTTAG
AAAAGGTTACATTTTAGTTTGTTTCTGGCGTTTTCAGAGACATATTTAGC
AATTATATGCGGAATTGGGCCTTTTCGAAACCCCGATGCAATGTTTGCTT
TATCTTACCCATTATTACATTTAACTTTGTTTATTTTTTTGAACAATCTT
TGATTACAAATTTCTATATAACATAAATGAATCCAATGTTAACCATTGGC
ATTCTTTATTAACATTCCTTTGATATTTTTTCAAAAAAATTACGATGTAA
TGAAACGCTACAAAGTTCAACCCTTGCACTATATATTTAAATGTTCGAAG
TCCTCTGTTGTGTAAAATAGTTAGTAATTCAGCATATTCTAAAGTTTAAG
GGTGCAGAAATGACATTCCTATTATAGATAGAAGCGCCTCTTTCTTTTAG
TGGGTTTCGGATTTGAATCCATGGCAGAAAAAACATTAATATTTGGAAAT
TCTGAACGTTTCAGTTTAGATTTGGGTTTGTTGCAAATTTTTTTAATTTT
TTCAAATTTTTGTCCAATATTTAAACATAATTTCTTTCAAGTTTTGAGCA
GCAGTTATTTTAAAATTTGGGCACAATTGTAATGTTAAAAATCGATATTA
AAGTGAAATAAAATCATTCTCTAATCTAATAATACATCTTTAATCATGAT
TCTAGCCACAAAAAGTCAAGGACAGGAATATAAAAGACAATTGCAGATTT
CCCAACAGAAAGTGACAGCCTTAGAAGCAGATGTCATCCGATTAGAAGGA
CAAGTTAAACGTCACAAATCCATTGCTGAAAGTTGTGAGAAACAAGAAGA
AGAATTAAAACAAGCTAAAAGGAAATACCAGAGAGAATTTCGAGAAGCTC
AAAATAAAATCGAAGACCTTAAATCGGAAAATGCAACTCTACAGAAAAAA
CTCGAGAAATATGCGAAACAGAAATCAAAAAAAGAAACAAATTGAAATTA
GAATTATTTTGCGAATTTTAATTATTAGAAATTTTGATTCTTCATATTTT
AATATGAAATATTTTGTAGTACAATTTTATAATAAATTAGACCAATTGCC
ACAGCTCAATATGTGAAATAACAATTGTGTAGGATTATTTCCGGGCGATA
GATTCGATAAATCCTTTTCCTAATCTCCACCATTGATATCTAACAAACCA
AAAAGATAAATGTAAATATATTTTTTGTTAAATTTTTCTTTGGTTATAAT
ATTGATTTTGTCTGTTTATCGTTAAAATAAAAGATGGACTATTTTTAGCA
GGAAATTAATTTCCAAGGATTTTTGGAATTTTTGTGTGCATTTATCGATT
TATAATAATTAGCTAATTTAGATGTGTGTTCGATTTTTATTGACTTATAC
TTGTGTCAGGTTTCGATTTTTATTGATTTTATTTTTATCTCTTGGATGTT
TCGGGAACACTGCAAGATTTCATTTTGTAATTAAACACGTCGATGTATTC
AAAAAGTGCTGATATTTTTATTTCAGTATCGCACGCACACACAATATGAT
TATTTGTGGAACACAGTATCCGGGAAATGTTCCCATCGGCAATTTTGGCA
CAATCCGTTTTTATGAAATTTTGGATGGCGATTCCTTATGCTTATCTCTC
GATTGCAGAATATTTTGTAATTAAACAAATCGATATTTATTAAGTCCATA
TATTTATATCAGTTTCTCACACGATATAATTACTGTAAATGCACTATTGG
CACACTTTGCTCTATTGATAAAATTCAGGTTGTCATTGATAATAGCTATT

protein sequence of SMED30000118-orf-1

>SMED30000118-orf-1 ID=SMED30000118-orf-1|Name=SMED30000118-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=100bp
MILATKSQGQEYKRQLQISQQKVTALEADVIRLEGQVKRHKSIAESCEKQ
EEELKQAKRKYQREFREAQNKIEDLKSENATLQKKLEKYAKQKSKKETN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR019139	LRRFIP1/2

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 9..99
None	No IPR available	PANTHER	PTHR19212:SF6	LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 2	coord: 7..89
IPR019139	Leucine-rich repeat flightless-interacting protein 1/2	PANTHER	PTHR19212	LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN	coord: 7..89

Main menu

Leucine-rich repeat flightless-interacting protein 2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Owlery

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