Voltage-dependent calcium channel subunit alpha-2/delta-2

Overview
NameVoltage-dependent calcium channel subunit alpha-2/delta-2
Smed IDSMED30000087
Length (bp)3017
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30000087) t-SNE clustered cells

Violin plots show distribution of expression levels for Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30000087) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30000087) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30000087) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000087

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 14

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30000087h1SMcG0002720 dd_Smed_v4_38777_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig36721uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig31644uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig31644newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0023063 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0023063 Contig36721uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30000087h1SMcG0002720 dd_Smed_v4_38777_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig36721uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig31644uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0002720 Contig31644newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0023063 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30000087h1SMcG0023063 Contig36721uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:HGNC Symbol;Acc:HGNC:1399])

HSP 1 Score: 134.806 bits (338), Expect = 2.223e-31
Identity = 69/209 (33.01%), Postives = 120/209 (57.42%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N   Q +          CF   VQA+ RNK  L   +  + A+GI +      FA  +   ++         ANCN++I++FTD G+E  +E    + N+ N  K +R+F + VG+       ++   CE +GY+  I ++GA+
Sbjct:  234 DLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF----NSNAQDVS---------CFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR------ANCNKIIMLFTDGGEERAQE----IFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAI 419

HSP 2 Score: 78.1814 bits (191), Expect = 6.634e-14
Identity = 50/142 (35.21%), Postives = 72/142 (50.70%), Query Frame = 2 
Query:  299 AKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL--PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            A+D    L+N    + ++L R    AE+    +Q+       EV Y N+KD   PE ++          + ++   F  ++    ++VHIPT+IY+   IVLN L WT  LD ++KKN E D  LLWQ F S T L R YP 
Sbjct:   83 ARDIEKLLSN----RSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPA 220
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:HGNC Symbol;Acc:HGNC:1399])

HSP 1 Score: 134.806 bits (338), Expect = 2.232e-31
Identity = 69/209 (33.01%), Postives = 120/209 (57.42%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N   Q +          CF   VQA+ RNK  L   +  + A+GI +      FA  +   ++         ANCN++I++FTD G+E  +E    + N+ N  K +R+F + VG+       ++   CE +GY+  I ++GA+
Sbjct:  234 DLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF----NSNAQDVS---------CFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR------ANCNKIIMLFTDGGEERAQE----IFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAI 419

HSP 2 Score: 78.1814 bits (191), Expect = 6.552e-14
Identity = 50/142 (35.21%), Postives = 72/142 (50.70%), Query Frame = 2 
Query:  299 AKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL--PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            A+D    L+N    + ++L R    AE+    +Q+       EV Y N+KD   PE ++          + ++   F  ++    ++VHIPT+IY+   IVLN L WT  LD ++KKN E D  LLWQ F S T L R YP 
Sbjct:   83 ARDIEKLLSN----RSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPA 220
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 134.42 bits (337), Expect = 2.732e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  265 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 458

HSP 2 Score: 82.4185 bits (202), Expect = 3.449e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  112 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPA 262
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 134.42 bits (337), Expect = 2.873e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  265 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 458

HSP 2 Score: 82.4185 bits (202), Expect = 3.332e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  112 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPA 262
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 134.42 bits (337), Expect = 2.899e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  265 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 458

HSP 2 Score: 82.0333 bits (201), Expect = 3.832e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  112 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPA 262
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: unc-36 (Voltage-dependent calcium channel unc-36 [Source:UniProtKB/Swiss-Prot;Acc:P34374])

HSP 1 Score: 88.5817 bits (218), Expect = 1.862e-17
Identity = 60/215 (27.91%), Postives = 102/215 (47.44%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFAT--FVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            D+FD R  +WY+  A++ K+V++++D SGSM G   ++ K   E +++T+  NDY  +  F   KN  +             C  T   +QA+ RNK  L +++   +++G A  + AL  A +     +N     N GA C  +I++ TD          + + +  N  K +R+F + VG+E    + +    C  RGY  H+  M  V   I
Sbjct:  231 DLFDCRNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTF--SKNTFL----------LDGCNGTNGLLQATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDINNGGGDNNRGA-CENVIMLITDGA----PNAYKKIFDMYNADKKVRVFTFLVGDEAIDFNEVREMACNNRGYMVHVANMADVDEKI 428
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: tag-180 (pep chromosome:WBcel235:II:11323051:11329429:-1 gene:WBGene00007041.1 transcript:T24F1.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-180)

HSP 1 Score: 76.6406 bits (187), Expect = 6.599e-14
Identity = 58/224 (25.89%), Postives = 109/224 (48.66%), Query Frame = 2 
Query: 1241 WRKKGT----DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFH-KFD-NRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKN---LRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            W+ + T    D+FD R R W+V   S PKD++ L+D SGS+ G  + L K  +  ++ T+  NDY    +F    N         P I       TF+ A+  NK   F+++  L  +  A+  T L+F+++      D N++   +  +  ++L+++FTD  DE+  +    +++    T+N   +RIF + +G   + + + +   C+  G +  I ++  V
Sbjct:  205 WKVEPTPITIDLFDPRFRPWFVNAESVPKDIVFLLDYSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNNHFN---------PIISCAN--RTFMPATTSNKKVFFEELGMLEEKDQAHFATPLKFSLDVLRGNLDSNQSLFADYRSEGHKLLIIFTDGVDEWPHQ----ILDEEFQTRNSELIRIFGFSMGYGTSLLPLQQYMACKSHGGYSEIDSIMDV 413
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: tag-180 (pep chromosome:WBcel235:II:11323051:11329147:-1 gene:WBGene00007041.1 transcript:T24F1.6b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-180)

HSP 1 Score: 76.6406 bits (187), Expect = 7.561e-14
Identity = 58/224 (25.89%), Postives = 109/224 (48.66%), Query Frame = 2 
Query: 1241 WRKKGT----DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFH-KFD-NRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKN---LRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            W+ + T    D+FD R R W+V   S PKD++ L+D SGS+ G  + L K  +  ++ T+  NDY    +F    N         P I       TF+ A+  NK   F+++  L  +  A+  T L+F+++      D N++   +  +  ++L+++FTD  DE+  +    +++    T+N   +RIF + +G   + + + +   C+  G +  I ++  V
Sbjct:  205 WKVEPTPITIDLFDPRFRPWFVNAESVPKDIVFLLDYSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNNHFN---------PIISCAN--RTFMPATTSNKKVFFEELGMLEEKDQAHFATPLKFSLDVLRGNLDSNQSLFADYRSEGHKLLIIFTDGVDEWPHQ----ILDEEFQTRNSELIRIFGFSMGYGTSLLPLQQYMACKSHGGYSEIDSIMDV 413
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: unc-36 (Voltage-dependent calcium channel unc-36 [Source:UniProtKB/Swiss-Prot;Acc:P34374])

HSP 1 Score: 75.485 bits (184), Expect = 1.958e-13
Identity = 59/258 (22.87%), Postives = 102/258 (39.53%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFAT--FVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEF------HKFDNRTEKGNEGAN-------------------------------------CNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            D+FD R  +WY+  A++ K+V++++D SGSM G   ++ K   E +++T+  NDY  +  F   KN  +             C  T   +QA+ RNK  L +++   +++G A  + AL  A +        +    + E     AN                                     C  +I++ TD          + + +  N  K +R+F + VG+E    + +    C  RGY  H+  M  V   I
Sbjct:  231 DLFDCRNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTF--SKNTFL----------LDGCNGTNGLLQATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDLKGSYALYTKEEMSMMSANATNEYQFHLELPEHVLAATKQYIDSINNGGGDNNRGACENVIMLITDGA----PNAYKKIFDMYNADKKVRVFTFLVGDEAIDFNEVREMACNNRGYMVHVANMADVDEKI 472
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0304694)

HSP 1 Score: 117.857 bits (294), Expect = 2.289e-26
Identity = 69/222 (31.08%), Postives = 110/222 (49.55%), Query Frame = 2 
Query: 1238 RWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++
Sbjct:  240 KWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMV 445

HSP 2 Score: 55.0694 bits (131), Expect = 3.757e-7
Identity = 22/57 (38.60%), Postives = 34/57 (59.65%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            SSVH+P  ++     V+ A++W+ NLD I++ N + D  L WQ+F S T   R +P 
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPA 238
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0087631)

HSP 1 Score: 117.857 bits (294), Expect = 2.360e-26
Identity = 69/222 (31.08%), Postives = 110/222 (49.55%), Query Frame = 2 
Query: 1238 RWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++
Sbjct:  240 KWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMV 445

HSP 2 Score: 55.0694 bits (131), Expect = 3.600e-7
Identity = 22/57 (38.60%), Postives = 34/57 (59.65%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            SSVH+P  ++     V+ A++W+ NLD I++ N + D  L WQ+F S T   R +P 
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPA 238
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0304695)

HSP 1 Score: 117.472 bits (293), Expect = 2.511e-26
Identity = 69/222 (31.08%), Postives = 110/222 (49.55%), Query Frame = 2 
Query: 1238 RWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++
Sbjct:  240 KWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMV 445

HSP 2 Score: 55.0694 bits (131), Expect = 3.964e-7
Identity = 22/57 (38.60%), Postives = 34/57 (59.65%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            SSVH+P  ++     V+ A++W+ NLD I++ N + D  L WQ+F S T   R +P 
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPA 238
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: Ca-Ma2d (gene:FBgn0261999 transcript:FBtr0303797)

HSP 1 Score: 101.679 bits (252), Expect = 2.103e-21
Identity = 66/223 (29.60%), Postives = 110/223 (49.33%), Query Frame = 2 
Query: 1238 RWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHK-FDNRTEKGNEGANCNRLIVVFTD--SGDEYDKEKIRSLMNRSNTTKNL--RIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            R  +   D +D R+R WY++ A+  KD+++L+D SGSM G    + K  +  ++DT   ND+  +  +    N  +            PCF    VQA+  N +   +QI QL   +G ANL  A E A     K +D+R    N  + CN+ I++ TD  +G+  +  +  +  N  N T  +  R+F Y +G+E+T +  ++   C  RGY+ H+  +  V
Sbjct:  255 RPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDII------------PCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTN--STCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEV 463

HSP 2 Score: 63.5438 bits (153), Expect = 1.017e-9
Identity = 29/76 (38.16%), Postives = 42/76 (55.26%), Query Frame = 2 
Query:  461 NSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            N EL  D   + T V    SSVH+P+ I+     VL  + W+ +LD ++++N + D  L WQYF S T + R YP 
Sbjct:  173 NMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPA 248
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: Ca-Ma2d (gene:FBgn0261999 transcript:FBtr0332356)

HSP 1 Score: 101.679 bits (252), Expect = 2.103e-21
Identity = 66/223 (29.60%), Postives = 110/223 (49.33%), Query Frame = 2 
Query: 1238 RWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHK-FDNRTEKGNEGANCNRLIVVFTD--SGDEYDKEKIRSLMNRSNTTKNL--RIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            R  +   D +D R+R WY++ A+  KD+++L+D SGSM G    + K  +  ++DT   ND+  +  +    N  +            PCF    VQA+  N +   +QI QL   +G ANL  A E A     K +D+R    N  + CN+ I++ TD  +G+  +  +  +  N  N T  +  R+F Y +G+E+T +  ++   C  RGY+ H+  +  V
Sbjct:  255 RPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDII------------PCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTN--STCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEV 463

HSP 2 Score: 63.5438 bits (153), Expect = 1.017e-9
Identity = 29/76 (38.16%), Postives = 42/76 (55.26%), Query Frame = 2 
Query:  461 NSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            N EL  D   + T V    SSVH+P+ I+     VL  + W+ +LD ++++N + D  L WQYF S T + R YP 
Sbjct:  173 NMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPA 248
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: CACNA2D1 (si:dkey-266j7.2 [Source:ZFIN;Acc:ZDB-GENE-060503-162])

HSP 1 Score: 144.05 bits (362), Expect = 1.964e-34
Identity = 73/209 (34.93%), Postives = 120/209 (57.42%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WYVQGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ V HF    N                CF   VQA+ RNK  L   +  + A+GI N     EFA N+       +      ANCN++I++FTD G+E  +E    + +R N  + +R+F + VG+       ++   C+ +GYF  I ++GA+
Sbjct:  218 DLYDVRRRPWYVQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNVVHFNTKVNNTA-------------CFDHLVQANVRNKKILKDAVQNITAKGITNYTKGFEFAFNQL------SNPNISRANCNKIIMLFTDGGEERAEE----IFSRHNIDRKVRVFTFSVGQHNYDTGPIKWMACQNKGYFYEIPSIGAI 403

HSP 2 Score: 80.4925 bits (197), Expect = 8.609e-15
Identity = 48/146 (32.88%), Postives = 77/146 (52.74%), Query Frame = 2 
Query:  284 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSEL----------LVDHPLFKTRVIA-NQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            N +++ +  +  + N  +K+  +L+     AE    ++Q+      +++ Y N+KD  E ++             + P FK R+ + N ++VHIPT+IY    IVLN L WT  L++++KKN E D  LLWQ F S T L R YP 
Sbjct:   60 NAVQLVETAARNIENFLKKRATALETLATAAENFQMEHQWKDEFA-DDIVYFNAKDNLETNDTEGRKNRIRPEFKEDPSFKNRLTSYNHTAVHIPTDIYDGSTIVLNELNWTEALEDVFKKNREEDPTLLWQVFGSATGLARFYPA 204
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2a (calcium channel, voltage-dependent, alpha 2/delta subunit 2a [Source:ZFIN;Acc:ZDB-GENE-050320-71])

HSP 1 Score: 135.961 bits (341), Expect = 1.889e-33
Identity = 78/220 (35.45%), Postives = 133/220 (60.45%), Query Frame = 2 
Query: 1232 GMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
              +W+     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+     K Y  +   PCF T VQA+ +NK ++FK+ +  ++A+G  +  T  +FA   F +  N T      ANCN++I++FTD G++  ++ I    N  N T  +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  192 ATKWKAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVIEMLDTLSDDDYVNVARF----NE-----KAYAVV---PCFTTLVQANIKNK-KIFKEAVMNMQAKGTTDYKTGFQFA---FDQLLNDTSAPR--ANCNKMIMMFTDGGEDRAQD-IFEKYNWPNRT--VRVFTFSVGQHNYDVTPLQWIACFNKGYYFEIPSIGAI 390

HSP 2 Score: 73.559 bits (179), Expect = 5.007e-13
Identity = 50/148 (33.78%), Postives = 75/148 (50.68%), Query Frame = 2 
Query:  293 EIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---------------DLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++A D + KL N  RK +E L R    AE+   ++ +   IK  ++QY ++K               D P +  L  VD P FK +V  + ++V IPT+IYK    +LN L WT +L+ ++ +N   D  L WQ F S T + R YP 
Sbjct:   49 KVAGDIA-KLLNRKRKALERLARE---AEDIQREHSWQDAIKENDIQYYDAKADSDVMDDDDGENLLDNPNSLSLEFVDDPNFKNKVNYSYTAVQIPTDIYKGSPTILNELNWTQSLERVFIENSREDPSLRWQVFGSTTGVTRYYPA 192
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2a (calcium channel, voltage-dependent, alpha 2/delta subunit 2a [Source:ZFIN;Acc:ZDB-GENE-050320-71])

HSP 1 Score: 135.961 bits (341), Expect = 1.948e-33
Identity = 78/220 (35.45%), Postives = 133/220 (60.45%), Query Frame = 2 
Query: 1232 GMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
              +W+     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+     K Y  +   PCF T VQA+ +NK ++FK+ +  ++A+G  +  T  +FA   F +  N T      ANCN++I++FTD G++  ++ I    N  N T  +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  191 ATKWKAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVIEMLDTLSDDDYVNVARF----NE-----KAYAVV---PCFTTLVQANIKNK-KIFKEAVMNMQAKGTTDYKTGFQFA---FDQLLNDTSAPR--ANCNKMIMMFTDGGEDRAQD-IFEKYNWPNRT--VRVFTFSVGQHNYDVTPLQWIACFNKGYYFEIPSIGAI 389

HSP 2 Score: 73.559 bits (179), Expect = 5.491e-13
Identity = 50/148 (33.78%), Postives = 75/148 (50.68%), Query Frame = 2 
Query:  293 EIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---------------DLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++A D + KL N  RK +E L R    AE+   ++ +   IK  ++QY ++K               D P +  L  VD P FK +V  + ++V IPT+IYK    +LN L WT +L+ ++ +N   D  L WQ F S T + R YP 
Sbjct:   48 KVAGDIA-KLLNRKRKALERLARE---AEDIQREHSWQDAIKENDIQYYDAKADSDVMDDDDGENLLDNPNSLSLEFVDDPNFKNKVNYSYTAVQIPTDIYKGSPTILNELNWTQSLERVFIENSREDPSLRWQVFGSTTGVTRYYPA 191
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 135.961 bits (341), Expect = 6.691e-32
Identity = 76/217 (35.02%), Postives = 128/217 (58.99%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK ++FK+ + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+
Sbjct:  174 WRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFDHLVQANVRNK-KIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACSNKGYYFEIRSICAI 369

HSP 2 Score: 71.633 bits (174), Expect = 3.869e-12
Identity = 50/177 (28.25%), Postives = 86/177 (48.59%), Query Frame = 2 
Query:  167 LQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++ E D+ +++     Q   +  IY+E  +K        NP +I +  +  +     KK ++L+R    AE    ++++   IK       + +D+     L +D    P FK +V  + ++V IPT+IYK   ++LN L WT  L+ ++ +N   D  LLWQ F S T + R YP 
Sbjct:    7 IEQEIDRVLQHISGAQQ---LKGIYLE--KKKHFSLVRNNPRDIVEKVATDIERLLAKKRKALERLASEAERLQKEHRWQDGIK-------DGEDIDSQMSLKLDFVYDPSFKNQVNYSHTAVQIPTDIYKGAPVILNELNWTQALERVFIENSRDDPSLLWQAFGSATGVTRYYPA 171
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 135.576 bits (340), Expect = 7.140e-32
Identity = 76/217 (35.02%), Postives = 128/217 (58.99%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK ++FK+ + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+
Sbjct:  188 WRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFDHLVQANVRNK-KIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACSNKGYYFEIRSICAI 383

HSP 2 Score: 81.2629 bits (199), Expect = 5.084e-15
Identity = 55/185 (29.73%), Postives = 91/185 (49.19%), Query Frame = 2 
Query:  167 LQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK--------DLPENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++ E D+ +++     Q   +  IY+E  +K        NP +I +  +  +     KK ++L+R    AE    ++++   IK E ++Y NSK        D+     L +D    P FK +V  + ++V IPT+IYK   ++LN L WT  L+ ++ +N   D  LLWQ F S T + R YP 
Sbjct:    6 IEQEIDRVLQHISGAQQ---LKGIYLE--KKKHFSLVRNNPRDIVEKVATDIERLLAKKRKALERLASEAERLQKEHRWQDGIKEENIEYYNSKAEMDYDGEDIDSQMSLKLDFVYDPSFKNQVNYSHTAVQIPTDIYKGAPVILNELNWTQALERVFIENSRDDPSLLWQAFGSATGVTRYYPA 185
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: cacna2d1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1 [Source:NCBI gene;Acc:100036724])

HSP 1 Score: 132.109 bits (331), Expect = 1.349e-30
Identity = 68/209 (32.54%), Postives = 120/209 (57.42%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N A  +           CF   VQA+ RNK +L + +  + A+G  +  T  +FA      FD         ANCN++I++FTD G++  KE   +     N  K +R+F + VG+       ++   C+ +G++  I ++GA+
Sbjct:  235 DLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAAF---NNNAHDV----------SCFNHLVQANVRNKKKLKEAVNNITAKGTTDYKTGFKFA------FDQLLNHNVSRANCNKIIMLFTDGGEDKAKETFEAY----NKDKTVRVFTFSVGQHNYDKGPIQWMACQNKGFYYEIPSIGAI 420

HSP 2 Score: 85.5001 bits (210), Expect = 3.381e-16
Identity = 50/148 (33.78%), Postives = 74/148 (50.00%), Query Frame = 2 
Query:  284 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL---PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            N  ++ +  +  +    R + ++L      AEE    +Q+        + Y N+KD    PE ++          +L D P+F+ +     S+VHIPT+IY+   IVLN L WT  LD ++KKN E D+ LLWQ F S T L R YP 
Sbjct:   74 NARQLVQSAATNIEKLLRNRSKALVHLAKKAEEIQESHQWRDQFGTNSIVYYNAKDDQMDPEKNDSDSASQKIKPVLQDDPVFRRQTSYQHSAVHIPTDIYEGSTIVLNELNWTAALDEVFKKNREEDETLLWQVFGSATGLARYYPA 221
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:100038148])

HSP 1 Score: 130.954 bits (328), Expect = 2.492e-30
Identity = 67/217 (30.88%), Postives = 121/217 (55.76%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +                CF   VQA+ RNK  + + + ++ A+G  +     E+A ++              ANCN++I++FTD G+    ++++ +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  132 WRAPSKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVTVASFHEKADPVS-------------CFRQLVQANVRNKKVIKEAVQEMVARGTTDYKAGFEYAFSQLQN------TSITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 325

HSP 2 Score: 65.855 bits (159), Expect = 3.454e-10
Identity = 31/72 (43.06%), Postives = 43/72 (59.72%), Query Frame = 2 
Query:  473 LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
              D P FK +V  N ++V IPT+IYK   ++LN L WT  L++++ +N   D  LLWQ F S T + R YP 
Sbjct:   58 FADDPNFKAKVNYNYTAVQIPTDIYKGSTVILNELNWTDALEDVFIQNRLEDPTLLWQVFGSATGVTRYYPA 129
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:100038148])

HSP 1 Score: 130.568 bits (327), Expect = 4.110e-30
Identity = 67/217 (30.88%), Postives = 121/217 (55.76%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +                CF   VQA+ RNK  + + + ++ A+G  +     E+A ++              ANCN++I++FTD G+    ++++ +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  234 WRAPSKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVTVASFHEKADPV-------------SCFRQLVQANVRNKKVIKEAVQEMVARGTTDYKAGFEYAFSQLQN------TSITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 427

HSP 2 Score: 76.6406 bits (187), Expect = 1.569e-13
Identity = 55/190 (28.95%), Postives = 97/190 (51.05%), Query Frame = 2 
Query:  167 LQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK--------------DLPENSELL--VDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            L+ EFD+ MR  F   Q+  +  +Y +  ++   E     P ++ +  +  + +   KK+ +L+R  + AE+    +++  +I+ E+++Y +SK                P +S  +   D P FK +V  N ++V IPT+IYK   ++LN L WT  L++++ +N   D  LLWQ F S T + R YP 
Sbjct:   47 LEQEFDRVMR-IFGGSQQ--LRGLYND--KRNLFEVKENVPRKLVEKVAGDIESLLAKKVRALRRLAEAAEKFQKAHRWQDNIREEDIEYYDSKADTEYEDLEGEEEPKEPTHSLKIDFADDPNFKAKVNYNYTAVQIPTDIYKGSTVILNELNWTDALEDVFIQNRLEDPTLLWQVFGSATGVTRYYPA 231
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3 [Source:NCBI gene;Acc:101732520])

HSP 1 Score: 120.939 bits (302), Expect = 2.241e-28
Identity = 70/222 (31.53%), Postives = 120/222 (54.05%), Query Frame = 2 
Query: 1232 GMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +Q +        +PC   T VQA + NK+   + + +L A+GI  LD AL  A +   +F++      EG+ C++ I++  D   D YD   I +  N  +  + +R+F Y +G E    D ++   C  +G+F  I  +  V
Sbjct:  116 GIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEEIQYV--------EPCLNGTLVQADRNNKEHFREHLDKLYAKGIGMLDIALNEAFDLLSEFNH----SGEGSVCSQAIMLIADGAVDTYD--NIFAKYNWPD--RKVRMFTYLIGREAAFADNMKWMACANKGFFTQISTLADV 317

HSP 2 Score: 53.1434 bits (126), Expect = 1.928e-6
Identity = 21/57 (36.84%), Postives = 33/57 (57.89%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            S V +PT +Y +   ++N + W+  L+ ++  N + D  L+WQYF S    FR YPG
Sbjct:   60 SDVQVPTNVYNKDPEIVNGIYWSEALNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPG 116
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3 [Source:NCBI gene;Acc:101732520])

HSP 1 Score: 121.324 bits (303), Expect = 2.276e-27
Identity = 70/222 (31.53%), Postives = 120/222 (54.05%), Query Frame = 2 
Query: 1232 GMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +Q +        +PC   T VQA + NK+   + + +L A+GI  LD AL  A +   +F++      EG+ C++ I++  D   D YD   I +  N  +  + +R+F Y +G E    D ++   C  +G+F  I  +  V
Sbjct:   84 GIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEEIQYV--------EPCLNGTLVQADRNNKEHFREHLDKLYAKGIGMLDIALNEAFDLLSEFNH----SGEGSVCSQAIMLIADGAVDTYD--NIFAKYNWPD--RKVRMFTYLIGREAAFADNMKWMACANKGFFTQISTLADV 285

HSP 2 Score: 53.9138 bits (128), Expect = 1.476e-6
Identity = 21/57 (36.84%), Postives = 33/57 (57.89%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            S V +PT +Y +   ++N + W+  L+ ++  N + D  L+WQYF S    FR YPG
Sbjct:   28 SDVQVPTNVYNKDPEIVNGIYWSEALNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPG 84
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 134.806 bits (338), Expect = 1.692e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 1.988e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 134.806 bits (338), Expect = 1.772e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 2.052e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 134.806 bits (338), Expect = 1.785e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 2.093e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 134.806 bits (338), Expect = 1.806e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 2.019e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 134.806 bits (338), Expect = 1.865e-31
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 2.185e-15
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|P54289|CA2D1_HUMAN (Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1 PE=1 SV=3)

HSP 1 Score: 134.806 bits (338), Expect = 1.072e-30
Identity = 69/209 (33.01%), Postives = 120/209 (57.42%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N   Q +          CF   VQA+ RNK  L   +  + A+GI +      FA  +   ++         ANCN++I++FTD G+E  +E    + N+ N  K +R+F + VG+       ++   CE +GY+  I ++GA+
Sbjct:  234 DLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF----NSNAQDVS---------CFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR------ANCNKIIMLFTDGGEERAQE----IFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAI 419

HSP 2 Score: 78.1814 bits (191), Expect = 3.146e-13
Identity = 50/142 (35.21%), Postives = 72/142 (50.70%), Query Frame = 2 
Query:  299 AKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL--PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            A+D    L+N    + ++L R    AE+    +Q+       EV Y N+KD   PE ++          + ++   F  ++    ++VHIPT+IY+   IVLN L WT  LD ++KKN E D  LLWQ F S T L R YP 
Sbjct:   83 ARDIEKLLSN----RSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPA 220
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q6PHS9|CA2D2_MOUSE (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Mus musculus OX=10090 GN=Cacna2d2 PE=1 SV=1)

HSP 1 Score: 134.806 bits (338), Expect = 1.184e-30
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.4185 bits (202), Expect = 1.390e-14
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q8CFG6|CA2D2_RAT (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Rattus norvegicus OX=10116 GN=Cacna2d2 PE=2 SV=1)

HSP 1 Score: 134.806 bits (338), Expect = 1.239e-30
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  268 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAI 461

HSP 2 Score: 82.8037 bits (203), Expect = 1.088e-14
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEEPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPA 265
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q9NY47|CA2D2_HUMAN (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Homo sapiens OX=9606 GN=CACNA2D2 PE=1 SV=2)

HSP 1 Score: 134.42 bits (337), Expect = 1.474e-30
Identity = 74/218 (33.94%), Postives = 126/218 (57.80%), Query Frame = 2 
Query: 1241 WR-KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  265 WRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAI 458

HSP 2 Score: 82.0333 bits (201), Expect = 1.968e-14
Identity = 46/151 (30.46%), Postives = 81/151 (53.64%), Query Frame = 2 
Query:  287 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK   ++LN L WT  L+N++ +N   D  LLWQ F S T + R YP 
Sbjct:  112 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPA 262
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|O08532|CA2D1_MOUSE (Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Mus musculus OX=10090 GN=Cacna2d1 PE=1 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 6.853e-30
Identity = 68/209 (32.54%), Postives = 119/209 (56.94%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N   Q +          CF   VQA+ RNK  L   +  + A+GI +      FA  +   ++         ANCN++I++FTD G+E  +E    +  + N  K +R+F + VG+       ++   CE +GY+  I ++GA+
Sbjct:  234 DLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF----NSNAQDVS---------CFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR------ANCNKIIMLFTDGGEERAQE----IFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAI 419

HSP 2 Score: 76.6406 bits (187), Expect = 8.880e-13
Identity = 49/142 (34.51%), Postives = 72/142 (50.70%), Query Frame = 2 
Query:  299 AKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL--PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            A+D    L+N    + ++L R    AE+    +Q+       EV Y N+KD   PE +E          + ++   F  ++    ++VHIPT+IY+   IVLN L WT  LD ++K+N + D  LLWQ F S T L R YP 
Sbjct:   83 ARDIEKLLSN----RSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPA 220
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267GU03 (VWFA domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig007739g2 PE=4 SV=1)

HSP 1 Score: 202.986 bits (515), Expect = 1.936e-49
Identity = 118/264 (44.70%), Postives = 158/264 (59.85%), Query Frame = 2 
Query: 1148 NNCSMLFHYFIWMKHL*CIF*FKNIL*LGMRWRKKGT--DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFP-----PGKNQAMQLIKDYPFIQTKP-----CFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTD---SGD-EYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSN 1891
            N+  +L+ YF   + +  IF        GM+WRK     DM+DVRRR WY QG+SSPKD++ LIDTSGSM G ++ LTK AV+ LIDT+GEND+IAV  +P     P       LI+D      KP     CF +FVQA++RNK RLF QI  L A GI N +  +EFA N+F  F N++   N+GA CN +I++ +D   SGD E   + IR   ++S+    +RIF Y VG+   PI+ L    CE RG+F  I A GAV++
Sbjct:  232 NDPDLLWQYFGSQRGIFRIF-------PGMKWRKPKNEIDMYDVRRRPWYTQGSSSPKDILFLIDTSGSMLGQSLTLTKHAVKSLIDTLGENDFIAVAQYPGKQVSPDHTAKPHLIEDRE--PKKPGANLTCFRSFVQATQRNKKRLFDQIMNLEAYGIVNFNDVIEFAYNQFEMFQNQS-VSNQGAMCNSIIMILSDGDVSGDVESATKLIRRWRSKSHYLDMIRIFTYSVGQHQNPIEPLLQIACENRGFFAEIPARGAVNH 485

HSP 2 Score: 97.8265 bits (242), Expect = 9.046e-17
Identity = 48/125 (38.40%), Postives = 75/125 (60.00%), Query Frame = 2 
Query:  314 NKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            N+L     KK+ SL+ AV FAE+    Y  +PH++ + V YI++K L ++   +    +F   V+ N+SSV+IP +++   +  LN + W+  LD I+ +N   D DLLWQYF SQ  +FR +PG
Sbjct:  129 NRLNRIVAKKISSLEDAVRFAEKAVVNYTMNPHLEEKHVTYISAKTLNDSDARMQYDRMFLQSVVMNESSVYIPNDMFNGDVEALNEIVWSTKLDKIFNQNKRNDPDLLWQYFGSQRGIFRIFPG 253
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267DMV8 (VWFA domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig012698g3 PE=4 SV=1)

HSP 1 Score: 198.364 bits (503), Expect = 4.705e-48
Identity = 109/239 (45.61%), Postives = 149/239 (62.34%), Query Frame = 2 
Query: 1232 GMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAM------QLIKDYPFIQTKP---CFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYD-----KEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIID 1900
            GM+WR  K   D++DVRRR WY QG++SP+DV+ ++DTSGSMHG A+ LTK AV  LI+T+GEND++AV  + PG+           L++D    ++K    CF +FVQA+KRNKDRLF QI  L A GI N   A++FA + F +F  +    N GA CN +I++FTD GD  D     ++ IR+  NRS     +RIF Y VG+   P + L    C  RGYF  I AMGAV++ ++
Sbjct:  215 GMKWRQPKGKIDVYDVRRRPWYTQGSASPRDVLFMVDTSGSMHGQALDLTKLAVVSLINTLGENDFVAVAQY-PGRQVTTDHTAKPHLLRDAVPEESKSNGTCFRSFVQATKRNKDRLFAQINDLSAYGIVNFYEAIDFAYSMFEEF-YKAPVNNHGALCNSMIMIFTD-GDVSDSMDETRQLIRTWRNRSALLDKIRIFTYSVGQHQNPTEPLLEVACSNRGYFAEIPAMGAVTSQVE 450

HSP 2 Score: 103.99 bits (258), Expect = 1.244e-18
Identity = 54/141 (38.30%), Postives = 80/141 (56.74%), Query Frame = 2 
Query:  302 KDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYP--------GKIDV 700
            K+ + KL     +KM ++K  V FAE  A  Y  +P I+  +V YI++K + E+   +    +F  +V+ NQSSVHIP E YK  + VLN + W+  LD ++  N   D +LLWQ++ SQ  +FR +P        GKIDV
Sbjct:   87 KNLAKKLTQVVSRKMRAIKELVTFAESAAASYIPNPAIEESQVSYIDAKLVEESDPRMEYDRMFLQKVVKNQSSVHIPVETYKGDVKVLNDIYWSNELDKVFYSNKRKDPELLWQFYGSQNGIFRMFPGMKWRQPKGKIDV 227
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A1S3JP64 (voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Lingula unguis OX=7574 GN=LOC106174785 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 5.861e-45
Identity = 90/222 (40.54%), Postives = 136/222 (61.26%), Query Frame = 2 
Query: 1241 WRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDN---RTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            W +   D++DVRRR WY QG+SSPK++M+L+DTSGS  G A++L K  V++L++T+GEND++AV ++   K + +Q    Y       CF  FVQA+ RNK  L + +  L+A G+A  + ALEFA   F +F+     +   N GA+CNR+I+V TD      K++  +++NR N  K +RIF Y +G+    I+ +    C+ RGYF  I AMGA+   +
Sbjct:  210 WTEAKPDLYDVRRRPWYTQGSSSPKNMMILVDTSGSTTGEALQLMKETVKQLLETLGENDFVAVANY--SKTEEIQDTVRY----VSECFQGFVQATHRNKQVLKEAVMDLQASGMAKWEDALEFAFKAFKEFEQDEKNSSMNNVGADCNRIIMVLTDGATA--KDEAATVLNRENPDKRIRIFTYAIGKTAAAIEAVRWLACKNRGYFSKIPAMGAIRTTV 423

HSP 2 Score: 96.6709 bits (239), Expect = 4.448e-17
Identity = 61/177 (34.46%), Postives = 93/177 (52.54%), Query Frame = 2 
Query:  161 ENLQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANE-FRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++L+   D+++ N     Q     N Y        ++   VN  ++ ++ +NKL  E   KK+E+LK++V  AEE A     D  +  +  ++ N+K L +++  L   P F   +    SSVHIP EIY     +LN LKWT  LD++WK+N E D +LLWQYF  Q    R+YP 
Sbjct:   37 KDLKQSLDEYVSNVLGEAQLQQSYNSY----DASKVQWKAVNGEDLVEETANKLGLEVLGKKIEALKKSVKAAEEIAAISPKDDSLTIDNYKFNNAKTLDKST--LAYSPKFGKGINETISSVHIPVEIYYGDKDILNGLKWTEGLDDVWKQNAEDDPNLLWQYFGGQKGFLRSYPA 207
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A2R2MM07 (voltage-dependent calcium channel subunit alpha-2/delta-2-like OS=Lingula unguis OX=7574 GN=LOC106161874 PE=4 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 2.961e-42
Identity = 90/222 (40.54%), Postives = 136/222 (61.26%), Query Frame = 2 
Query: 1241 WRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDN---RTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNII 1897
            W +   D++DVRRR WY QG+SSPK++M+L+DTSGS  G A++L K  V++L++T+GEND++AV ++   K + +Q    Y       CF  FVQA+ RNK  L + +  L+A G+A  + ALEFA   F +F+     +   N GA+CNR+I+V TD      K++  +++NR N  K +RIF Y +G+    I+ +    C+ RGYF  I AMGA+   +
Sbjct:   95 WTEAKPDLYDVRRRPWYTQGSSSPKNMMILVDTSGSTTGEALQLMKETVKQLLETLGENDFVAVANY--SKTEEIQDTVRY----VSECFQGFVQATHRNKQVLKEAVMDLQASGMAKWEDALEFAFKAFKEFEQDEKNSSMNNVGADCNRIIMVLTDGATA--KDEAATVLNRENPDKQIRIFTYAIGKTAAAIEAVRWLACKNRGYFSKIPAMGAIRTTV 308

HSP 2 Score: 76.2554 bits (186), Expect = 2.992e-10
Identity = 38/86 (44.19%), Postives = 51/86 (59.30%), Query Frame = 2 
Query:  431 QYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++ N+K L +++  L   P F   +    SSVHIP EIY     +LN LKWT  LD++WK+N E D +LLWQYF  Q    R+YP 
Sbjct:    9 KFNNAKTLDKST--LAYSPKFGKGINETISSVHIPVEIYYGDKDILNGLKWTEGLDDVWKQNAEDDPNLLWQYFGGQKGFLRSYPA 92
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A2T7NSC3 (VWFA domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_14540 PE=4 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 6.581e-42
Identity = 95/227 (41.85%), Postives = 136/227 (59.91%), Query Frame = 2 
Query: 1238 RWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF--ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKF--DNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDV 1903
            RW   G  D+FDVRR+ WY QG+SSPKD+++LIDTSGS HG A++L K+AV+ ++DT+GEND++ +  F    N A     DY       CF    FVQA+ RNK +L + + +L AQ  A+    L FA  +F +F  +  +   N GANCN++I++ TD G + + E +    N  N  K++R+F Y VG   TP+  ++   C  RGYF HI AMGA+   + V
Sbjct:  260 RWETHGDVDLFDVRRQSWYTQGSSSPKDMLILIDTSGSTHGQALQLMKNAVKSILDTLGENDFVNIVRF---SNDA-----DY----VSACFNHTPFVQANYRNKKQLERDVDKLEAQNQADYKAGLRFAFQKFEEFSANQSSSDKNIGANCNKVIILLTDGGTD-NAEDVFKEYNWPN--KSVRVFTYAVGPTATPVAAIKWMACANRGYFSHIPAMGAIRARVQV 471

HSP 2 Score: 99.3673 bits (246), Expect = 6.962e-18
Identity = 70/187 (37.43%), Postives = 96/187 (51.34%), Query Frame = 2 
Query:  146 ILSSLENLQMEFDKFMRN---QFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEV---QYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +  SLE++Q+  D F ++   + +VF            G K GI    VN   + ++ S+ L+     KME+L   V  AE+ A KY   P  KPE+V    Y N+K +P+   +   H  FK  V    SSVHIP EIY     +LN L WT  LD  + KN++ D+ +LWQYF SQT   RTYP 
Sbjct:   76 VFPSLEHVQVWGDNFRQDLLYKLNVFTGHAALVQSYNSGSKNGINFQLVNETALVENMSSSLSAMLSTKMEALWALVHAAEDAAKKYV--PTEKPEKVNGSHYKNAKSMPDVQLVYDKH--FKQEVNFTFSSVHIPVEIYDGDSDILNGLNWTSQLDEQFMKNLQNDRTMLWQYFGSQTGFMRTYPA 258
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 136.732 bits (343), Expect = 6.951e-34
Identity = 77/217 (35.48%), Postives = 128/217 (58.99%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK R+FK+ + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+
Sbjct:  175 WRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFKHLVQANVRNK-RIFKEHVSQMQAKGTTDYKSGFRFAFNQLLNNTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQHNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIRSICAI 370

HSP 2 Score: 68.1662 bits (165), Expect = 2.040e-11
Identity = 45/136 (33.09%), Postives = 69/136 (50.74%), Query Frame = 2 
Query:  284 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKP-EEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            NP EI +  ++ +     KK  +L++    AE     +++   IK  +E +   S  L    E + D P FK  V  + ++V IPT+IYK   ++LN L WT  L+ ++ +N   D  LLWQ F S T + R YP 
Sbjct:   42 NPREIVEKVASDIEKLLAKKKRALEKLASEAERVQKAHRWQDSIKDGDEFEAQMSLKL----EFVYD-PNFKNNVNYSYTAVQIPTDIYKGAPVILNELNWTQALERVFMENSREDPSLLWQAFGSATGVTRYYPA 172
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: si:dkey-266j7.2 (calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:HGNC Symbol;Acc:HGNC:1399])

HSP 1 Score: 139.813 bits (351), Expect = 2.858e-33
Identity = 74/209 (35.41%), Postives = 119/209 (56.94%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WYVQGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ V +F    N                CF   VQA+ RNK  L   +  + A+GI N     EFA      F   ++     ANCN++I++FTD G+E  +E    + +R N  K +RIF + VG+       ++   C  +GYF  I ++GA+
Sbjct:  183 DLYDVRRRPWYVQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNVVNFNTRVNNTA-------------CFDHLVQANVRNKKILKDGVQNITAKGITNYTKGFEFA------FKQLSDPNVTRANCNKIIMLFTDGGEERAQE----IFSRYNPEKKVRIFTFSVGQHNYDTGPIQWMACANKGYFYEIPSIGAI 368

HSP 2 Score: 76.6406 bits (187), Expect = 9.163e-14
Identity = 38/71 (53.52%), Postives = 47/71 (66.20%), Query Frame = 2 
Query:  479 DHPLFKTRVIA-NQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            + P FK R+I+ N S+VHIPT+IY    IVLN L WT  L++++KKN E D  LLWQ F S T L R YP 
Sbjct:   99 EDPSFKNRLISYNHSAVHIPTDIYDGSTIVLNELNWTEALEDVFKKNREEDPTLLWQVFGSATGLARYYPA 169
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 137.117 bits (344), Expect = 1.912e-32
Identity = 77/217 (35.48%), Postives = 128/217 (58.99%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK R+FK+ + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+
Sbjct:  174 WRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFKHLVQANVRNK-RIFKEHVSQMQAKGTTDYKSGFRFAFNQLLNNTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQHNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIRSICAI 369

HSP 2 Score: 68.1662 bits (165), Expect = 3.573e-11
Identity = 45/136 (33.09%), Postives = 69/136 (50.74%), Query Frame = 2 
Query:  284 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKP-EEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            NP EI +  ++ +     KK  +L++    AE     +++   IK  +E +   S  L    E + D P FK  V  + ++V IPT+IYK   ++LN L WT  L+ ++ +N   D  LLWQ F S T + R YP 
Sbjct:   41 NPREIVEKVASDIEKLLAKKKRALEKLASEAERVQKAHRWQDSIKDGDEFEAQMSLKL----EFVYD-PNFKNNVNYSYTAVQIPTDIYKGAPVILNELNWTQALERVFMENSREDPSLLWQAFGSATGVTRYYPA 171
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: cacna2d3 (calcium channel, voltage dependent, alpha2/delta subunit 3 [Source:ZFIN;Acc:ZDB-GENE-030616-133])

HSP 1 Score: 120.168 bits (300), Expect = 4.132e-27
Identity = 71/222 (31.98%), Postives = 115/222 (51.80%), Query Frame = 2 
Query: 1232 GMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDE-YDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + +  V  ++DT+G++D+  +  +    NQ +  +        +PC   T VQA + NKD   + + +L A+GI  L  AL  A    ++F+    +   G+ C+R I++ TD   E YD          +   + +RIF Y +G E    D L+   C  +GYF  I  +  V
Sbjct:  187 GVKWHPDEHGVISFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIARQTVSSILDTLGDDDFFNIIAY----NQEIHYV--------EPCLNGTLVQADRTNKDHFREHLDKLFAKGIGLLGEALTEAFTILNEFN----QAGRGSVCSRAIMLVTDGATEMYDD----VFAKYNWPERKVRIFPYLIGRESAFADNLKWMACANKGYFSQISTLADV 388

HSP 2 Score: 59.6918 bits (143), Expect = 1.706e-8
Identity = 40/121 (33.06%), Postives = 60/121 (49.59%), Query Frame = 2 
Query:  356 KRAVDFAEEEATKYQYDPHIKPE--EVQYINSKDLPENS-----ELLV---DHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            KR V+ AEE   +++ +P ++ E      IN  D   NS     E L+   DH      V  + S V +PT +Y +   ++N + W+  L+ ++  N E D  L+WQYF S    FR YPG
Sbjct:   68 KRLVEAAEEAHLQHEENPDLQYEYFNAVLINEVDEDGNSVELGGEFLLEPNDH-FNNLSVNLSLSVVQVPTNMYNKDPDIVNGVYWSEALNKVFVDNFERDPSLIWQYFGSAKGFFRQYPG 187
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: cacna2d2a (calcium channel, voltage-dependent, alpha 2/delta subunit 2a [Source:ZFIN;Acc:ZDB-GENE-050320-71])

HSP 1 Score: 115.931 bits (289), Expect = 5.832e-27
Identity = 63/199 (31.66%), Postives = 115/199 (57.79%), Query Frame = 2 
Query: 1289 YVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            Y+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +             CF T VQA+ +NK    +++  ++A+G  +  +  +FA   F +  N T      ANCN++I++FTD G++  ++ I  + N  N  K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  193 YIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVIEMLDTLSDDDYVNVAQFNEKADAVVS------------CFKTLVQANVKNKKIFKEKVMHMQAKGTTDYKSGFKFA---FEQLLNSTAP---RANCNKMIMMFTDGGEDRAQD-IFEMYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAI 370

HSP 2 Score: 59.3066 bits (142), Expect = 1.227e-8
Identity = 50/158 (31.65%), Postives = 74/158 (46.84%), Query Frame = 2 
Query:  296 IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENS---ELLVDHPL-----------FKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPGKIDVVSSSCICSF 727
            +A+D + KL N  RK +E L R    AE+  T++ +   IK     +I +  +P +    E L+D+P            FK +V  + ++V IPT+IYK    +LN L WT  L+ ++  N   D  L WQ F S T   +TY          C C F
Sbjct:   50 VARDIA-KLLNSKRKALERLARE---AEQIQTEHPWQDSIKVS--WFILAGSIPSDDGDDENLLDNPYSLPLEFVHDPNFKNKVNYSYTAVQIPTDIYKGSPTILNELNWTQALERVFIDNSREDPSLRWQVFGSATG--KTY---------FCFCVF 190
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Match: cacna2d1a (calcium channel, voltage-dependent, alpha 2/delta subunit 1a [Source:ZFIN;Acc:ZDB-GENE-041210-215])

HSP 1 Score: 134.42 bits (337), Expect = 2.608e-32
Identity = 72/216 (33.33%), Postives = 123/216 (56.94%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            W   G  D+FDVRRR WY+QGASSPKD++++ID SGS+ G+ +KL K +V ++++T+ ++DY+ V  F    N+A+ +           CF   VQA+ RNK  L + + +L A+G+ N   A  +A      F+         ANCN++I++FTD G++  ++      N +   K +R+F + VG+    +  ++   C  +G++  I ++GA+
Sbjct:   65 WVAPGDVDLFDVRRRPWYIQGASSPKDMVIIIDVSGSVSGLTLKLMKKSVSEMLETLSDDDYVNVASF---HNEAVPV----------SCFNHLVQANVRNKQMLSESVEKLTAKGMTNYKAAFTYA------FEQLLNTNVTRANCNKMIMMFTDGGEDRAQDVFE---NYNWPKKEVRVFTFSVGQHNYNVAPIQWMACANKGFYFEIPSIGAI 258

HSP 2 Score: 50.447 bits (119), Expect = 2.235e-6
Identity = 23/43 (53.49%), Postives = 26/43 (60.47%), Query Frame = 2 
Query:  560 IVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            I+LN L WT  LD ++K N E D  LLWQ F S T L R YP 
Sbjct:   20 IILNELNWTAGLDEVFKLNKEEDPTLLWQVFGSATGLTRFYPA 62
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Match: cacna2d4b (calcium channel, voltage-dependent, alpha 2/delta subunit 4b [Source:ZFIN;Acc:ZDB-GENE-100422-18])

HSP 1 Score: 119.398 bits (298), Expect = 1.929e-28
Identity = 70/234 (29.91%), Postives = 127/234 (54.27%), Query Frame = 2 
Query: 1232 GMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDVRILLWL 1921
            G++W   + G   FD R R WY+Q A+SPKD+++L+D SGSM G+ + + K  +  ++DT+G+ND++ V  +    N+ +  I        +PCF    VQA++ N++  FKQ+ + + AQG+A+L  ALE       +F+       +G++CN+ ++V TD   E  +E        ++  K +RIF Y +G E+   + ++   C  + +F  I  +   +N +   I+ ++
Sbjct:  160 GIKWTPDENGVISFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRLTIAKQTISTILDTLGDNDFVNVIAY----NEQLHYI--------EPCFEGGMVQANRDNREH-FKQLLEDMHAQGVADLANALEEGFVILDQFN----ATGQGSSCNQALMVVTDGAVETFEEVFEKY---NSPDKKVRIFTYLIGRELAFANPIKWMACANKAHFTRIIVLKDTTNNVVCLIIYFV 373

HSP 2 Score: 58.5362 bits (140), Expect = 4.607e-9
Identity = 34/127 (26.77%), Postives = 62/127 (48.82%), Query Frame = 2 
Query:  335 RKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE--------LLVDHPLFKTRVI-ANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            RK    ++R V+ AEE   K++++  ++ +    +   D+ E           +L  +  F    +  + S+V +PT +Y +   ++N   W+  L+ +++ N E D  L WQY+ S T  FR YPG
Sbjct:   34 RKTEAEIQRLVEAAEEADLKHEFNSEMQYDYYNAVFINDVDEEGNYIELAREFILEPNAHFNNLAVNTSLSNVQVPTNVYNKEPNIVNGAFWSEALNPVFEDNFERDATLTWQYYGSSTGFFRQYPG 160
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO29939 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T278])

HSP 1 Score: 78.1814 bits (191), Expect = 2.524e-17
Identity = 35/68 (51.47%), Postives = 48/68 (70.59%), Query Frame = 2 
Query: 1232 GMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAV 1432
            G +WR     DM+D RRR WY+QG+SSPKD+++L+D SGSM G  I + K A   L+DT+ END++ V
Sbjct:   43 GYKWRTPNDKDMYDHRRRGWYIQGSSSPKDMVILLDLSGSMTGSKIAIVKLAATYLLDTLQENDFVNV 110

HSP 2 Score: 48.521 bits (114), Expect = 5.430e-7
Identity = 18/43 (41.86%), Postives = 29/43 (67.44%), Query Frame = 2 
Query:  560 IVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            ++LN+ KWT  LD  +++N+E +  LLWQ   + T ++R YPG
Sbjct:    1 VILNSAKWTEGLDKYFRENMEKEPSLLWQLAGTSTGVYRAYPG 43
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO38678 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCF0])

HSP 1 Score: 72.4034 bits (176), Expect = 2.953e-15
Identity = 30/69 (43.48%), Postives = 47/69 (68.12%), Query Frame = 2 
Query: 1232 GMRWRKKG--TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAV 1432
            G  W +     D++D R+R WY+QGA+SPKDV++++D SGSM G+ +++ K +   LIDT  +ND+  V
Sbjct:   42 GSAWNQPNGQVDLYDARKRIWYIQGATSPKDVIIMVDASGSMRGVPMRIAKLSAMALIDTFEDNDFFNV 110
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO48210 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKA1])

HSP 1 Score: 61.2326 bits (147), Expect = 1.935e-9
Identity = 54/198 (27.27%), Postives = 93/198 (46.97%), Query Frame = 2 
Query: 1265 FDVRRRQWYVQGASS-PKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFA---INEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLR--IFIYYVGEEITP--IDVLEN 1831
            +D R R WYV+ AS  PKDV++++D SGSM G  + + K A + ++DT+   D +A   F  G  +      D    + + CF ++  +AS  N D L K +    A G      A   A   +++++K  N T +         +I+  TD     D   I + +   N   + +  I  + +G  I+P  +D+L++
Sbjct:  194 YDPRYRPWYVEAASPQPKDVILVVDYSGSMGGSRLPIAKEAAKTVLDTLNPRDRVAFLAFESGVRRVKVTSGD---AKDEKCFESSLAKASPVNIDILKKFLDGEYASGGTMYAIAFNAAFDILDKYYKEKNTTRR--------PVILFMTDGAPNDDPGTILNTVKTRNQGLSTKADILTFGMGGGISPAGVDLLQS 380
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO29938 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T277])

HSP 1 Score: 51.2174 bits (121), Expect = 1.338e-8
Identity = 20/43 (46.51%), Postives = 32/43 (74.42%), Query Frame = 2 
Query:  518 SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQ 646
            S+VH+PT++YK   ++LN+ KWT  LD  +++N+E +  LLWQ
Sbjct:    6 STVHVPTDVYKGSKVILNSAKWTEGLDKYFRENMEKEPSLLWQ 48
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO48211 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKA2])

HSP 1 Score: 57.7658 bits (138), Expect = 1.489e-8
Identity = 42/136 (30.88%), Postives = 68/136 (50.00%), Query Frame = 2 
Query: 1265 FDVRRRQWYVQGASS-PKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFA---INEFHKFDNRTEK 1657
            +D R R WYV+ AS  PKDV++++D SGSM G  + + K A + ++DT+   D +A   F  G  +      D    + + CF ++  +AS  N D L K +    A G      A   A   +++++K  N T +
Sbjct:  194 YDPRYRPWYVEAASPQPKDVILVVDYSGSMGGSRLPIAKEAAKTVLDTLNPRDRVAFLAFESGVRRVKVTSGD---AKDEKCFESSLAKASPVNIDILKKFLDGEYASGGTMYAVAFNAAFDILDKYYKEKNTTRR 326
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 139.813 bits (351), Expect = 3.295e-33
Identity = 73/217 (33.64%), Postives = 125/217 (57.60%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G+    ++ + +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  234 WRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGE----DRAQDIFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAI 429

HSP 2 Score: 70.4774 bits (171), Expect = 7.875e-12
Identity = 48/147 (32.65%), Postives = 73/147 (49.66%), Query Frame = 2 
Query:  296 IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---------------DLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +A+D S KL N  RK +E L R    AE+   ++ +   +   ++ Y +SK               ++  + EL  V  P FK +V  + S+V IPT+IYK   ++LN L WT  L+ ++ +N   D  L WQ F S T + R YP 
Sbjct:   89 VARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTENDISYYDSKADSDYMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPA 231
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 139.813 bits (351), Expect = 3.329e-33
Identity = 73/217 (33.64%), Postives = 125/217 (57.60%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G+    ++ + +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  234 WRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGE----DRAQDIFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAI 429

HSP 2 Score: 70.4774 bits (171), Expect = 7.075e-12
Identity = 48/147 (32.65%), Postives = 73/147 (49.66%), Query Frame = 2 
Query:  296 IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---------------DLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +A+D S KL N  RK +E L R    AE+   ++ +   +   ++ Y +SK               ++  + EL  V  P FK +V  + S+V IPT+IYK   ++LN L WT  L+ ++ +N   D  L WQ F S T + R YP 
Sbjct:   89 VARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTENDISYYDSKADSDYMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPA 231
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 139.813 bits (351), Expect = 3.360e-33
Identity = 73/217 (33.64%), Postives = 125/217 (57.60%), Query Frame = 2 
Query: 1241 WRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G+    ++ + +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+
Sbjct:  219 WRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGE----DRAQDIFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAI 414

HSP 2 Score: 70.8626 bits (172), Expect = 5.742e-12
Identity = 46/132 (34.85%), Postives = 70/132 (53.03%), Query Frame = 2 
Query:  296 IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +A+D S KL N  RK +E L R    AE+   ++ +   +  E+ +     ++  + EL  V  P FK +V  + S+V IPT+IYK   ++LN L WT  L+ ++ +N   D  L WQ F S T + R YP 
Sbjct:   89 VARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPA 216
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d1a (voltage-dependent calcium channel subunit alpha-2/delta-1 [Source:NCBI gene;Acc:101156213])

HSP 1 Score: 137.887 bits (346), Expect = 1.216e-32
Identity = 70/209 (33.49%), Postives = 122/209 (58.37%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL K++V K+++T+ ++D++ V  F    N++ + +          CF   VQA+ RNK  L   + +++A+GI N  +  E A      F    +     A+CNR+I++FTD G+    EK   ++ + N  + +RIF + VG+       ++   C  +GY+  I ++GA+
Sbjct:  239 DLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIKTSVHKMLETLSDDDFVNVVSF----NKSARPVA---------CFEHLVQANVRNKRVLKDAVQRIKAEGITNYTSGFELA------FAQLAQTNVSRADCNRIIMLFTDGGE----EKAEEILEKLNKNREVRIFTFSVGQHSYDKGPVQWMACTNKGYYYEIPSIGAI 424

HSP 2 Score: 77.411 bits (189), Expect = 5.295e-14
Identity = 64/196 (32.65%), Postives = 99/196 (50.51%), Query Frame = 2 
Query:  143 DILSSLENLQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDF------AEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPGKIDVVSSS 712
            D  S LENL   + K  +  FSV  E   A   +     G IE    N  +  K  + + A +F+K+ +  +++ D       A++   K +++   K E+   + ++ +P++     D   FK RV  N ++VHIPT+IY+   I+LN L WT  L+++++KN E D  LLWQ F S T L R YP      SSS
Sbjct:   44 DTASGLENLIKIYHKH-KTHFSV--ESNNARQLVATAS-GNIEKLLDNRSQALKRLATE-AEKFQKEHQWTEKSEDNKIFYYNAKDGTNKTEFEEKQKGEDGDELKNRFIPDDFTNETDEN-FKRRVSFNTTAVHIPTDIYEGSTIILNELNWTDALEDVFRKNREEDPSLLWQVFGSATGLARYYPASPWTDSSS 233
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2b (voltage-dependent calcium channel subunit alpha-2/delta-2 [Source:NCBI gene;Acc:101156079])

HSP 1 Score: 135.576 bits (340), Expect = 5.770e-32
Identity = 70/209 (33.49%), Postives = 121/209 (57.89%), Query Frame = 2 
Query: 1259 DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK    + + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++     M  +   K +R+F + VG+    +  L+   C  +GY+  I ++ A+
Sbjct:  175 DLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVMEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFKHLVQANVRNKKIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD---VFMQYNWPNKTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIRSICAI 363

HSP 2 Score: 62.003 bits (149), Expect = 2.817e-9
Identity = 44/140 (31.43%), Postives = 69/140 (49.29%), Query Frame = 2 
Query:  284 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQY-INSKDLPENSELL----VDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +P  I +  +  +     KK ++L+R    AE    ++ +   IK   V Y ++ +   EN   +    V  P FK  V  + ++V IPT+IYK   ++LN L WT  L+ ++ +N   D  LLWQ F S T + R YP 
Sbjct:   29 HPRRIVEKVALDIERLLAKKRKALERLASEAERLQQEHLWQDGIK---VNYSMDGEGEVENPSHIKLEFVYDPNFKNNVNYSYTAVQIPTDIYKGAPVILNELNWTQALEKVFMENSREDPSLLWQAFGSATGVTRYYPA 165
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000021966.1 (SMESG000021966.1)

HSP 1 Score: 554.673 bits (1428), Expect = 7.672e-180
Identity = 265/290 (91.38%), Postives = 266/290 (91.72%), Query Frame = 2 
Query: 1232 GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDVRILLWLNF*K*S*AL*LY*I*LQKYSKTVHYHTIHRENQMEDNEFRIDLVSINEDGFHNPEDFPPM 2101
            GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIID                        KYSKTVHYHTIHRENQMEDNEFRIDLVS+NEDGFHNPEDFPPM
Sbjct:  182 GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIID------------------------KYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPM 447

HSP 2 Score: 320.857 bits (821), Expect = 8.283e-93
Identity = 159/185 (85.95%), Postives = 165/185 (89.19%), Query Frame = 2 
Query:  134 MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIY EIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKE   +LN LKWT  L+NI+   I    +L +QYFAS T +   YPG
Sbjct:    1 MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPG 182

HSP 3 Score: 90.5077 bits (223), Expect = 3.878e-18
Identity = 42/43 (97.67%), Postives = 42/43 (97.67%), Query Frame = 1 
Query:  868 DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGF 996
            DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPG 
Sbjct:  141 DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGM 183
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000021966.1 (SMESG000021966.1)

HSP 1 Score: 554.673 bits (1428), Expect = 1.205e-179
Identity = 265/290 (91.38%), Postives = 266/290 (91.72%), Query Frame = 2 
Query: 1232 GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDVRILLWLNF*K*S*AL*LY*I*LQKYSKTVHYHTIHRENQMEDNEFRIDLVSINEDGFHNPEDFPPM 2101
            GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIID                        KYSKTVHYHTIHRENQMEDNEFRIDLVS+NEDGFHNPEDFPPM
Sbjct:  200 GMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIID------------------------KYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPM 465

HSP 2 Score: 324.709 bits (831), Expect = 3.499e-94
Identity = 161/187 (86.10%), Postives = 167/187 (89.30%), Query Frame = 2 
Query:  128 KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIY EIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKE   +LN LKWT  L+NI+   I    +L +QYFAS T +   YPG
Sbjct:   17 KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPG 200

HSP 3 Score: 90.5077 bits (223), Expect = 4.182e-18
Identity = 42/43 (97.67%), Postives = 42/43 (97.67%), Query Frame = 1 
Query:  868 DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGF 996
            DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPG 
Sbjct:  159 DSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGM 201
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 80.8777 bits (198), Expect = 3.973e-15
Identity = 62/234 (26.50%), Postives = 100/234 (42.74%), Query Frame = 2 
Query: 1232 GMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA------TFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y       CFA        +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V
Sbjct:  219 GIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLF----------TKEY-------CFADNYTSGILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADV 428

HSP 2 Score: 55.4546 bits (132), Expect = 2.139e-7
Identity = 38/153 (24.84%), Postives = 74/153 (48.37%), Query Frame = 2 
Query:  281 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     + +   WT +LD  ++   + D  L WQ+F S T LF+ YPG
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKD-DSQLKWQFFCSNTGLFKIYPG 219
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 80.4925 bits (197), Expect = 4.833e-15
Identity = 62/234 (26.50%), Postives = 100/234 (42.74%), Query Frame = 2 
Query: 1232 GMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA------TFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y       CFA        +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V
Sbjct:  219 GIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLF----------TKEY-------CFADNYTSGILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADV 428

HSP 2 Score: 55.4546 bits (132), Expect = 2.357e-7
Identity = 38/153 (24.84%), Postives = 74/153 (48.37%), Query Frame = 2 
Query:  281 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     + +   WT +LD  ++   + D  L WQ+F S T LF+ YPG
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKD-DSQLKWQFFCSNTGLFKIYPG 219
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 80.4925 bits (197), Expect = 5.591e-15
Identity = 62/234 (26.50%), Postives = 100/234 (42.74%), Query Frame = 2 
Query: 1232 GMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA------TFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV 1885
            G+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y       CFA        +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V
Sbjct:  219 GIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLF----------TKEY-------CFADNYTSGILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADV 428

HSP 2 Score: 55.4546 bits (132), Expect = 2.272e-7
Identity = 38/153 (24.84%), Postives = 74/153 (48.37%), Query Frame = 2 
Query:  281 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRTYPG 688
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     + +   WT +LD  ++   + D  L WQ+F S T LF+ YPG
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKD-DSQLKWQFFCSNTGLFKIYPG 219
The following BLAST results are available for this feature:
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CACNA2D12.223e-3133.01calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D12.232e-3133.01calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D22.732e-3133.94calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D22.873e-3133.94calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D22.899e-3133.94calcium voltage-gated channel auxiliary subunit al... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
unc-361.862e-1727.91Voltage-dependent calcium channel unc-36 [Source:... [more]
tag-1806.599e-1425.89pep chromosome:WBcel235:II:11323051:11329429:-1 ge... [more]
tag-1807.561e-1425.89pep chromosome:WBcel235:II:11323051:11329147:-1 ge... [more]
unc-361.958e-1322.87Voltage-dependent calcium channel unc-36 [Source:... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
stj2.289e-2631.08gene:FBgn0261041 transcript:FBtr0304694[more]
stj2.360e-2631.08gene:FBgn0261041 transcript:FBtr0087631[more]
stj2.511e-2631.08gene:FBgn0261041 transcript:FBtr0304695[more]
Ca-Ma2d2.103e-2129.60gene:FBgn0261999 transcript:FBtr0303797[more]
Ca-Ma2d2.103e-2129.60gene:FBgn0261999 transcript:FBtr0332356[more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CACNA2D11.964e-3434.93si:dkey-266j7.2 [Source:ZFIN;Acc:ZDB-GENE-060503-1... [more]
cacna2d2a1.889e-3335.45calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d2a1.948e-3335.45calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d2b6.691e-3235.02calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d2b7.140e-3235.02calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d11.349e-3032.54calcium channel, voltage-dependent, alpha 2/delta ... [more]
CACNA2D22.492e-3030.88calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D24.110e-3030.88calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D32.241e-2831.53calcium channel, voltage-dependent, alpha 2/delta ... [more]
CACNA2D32.276e-2731.53calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cacna2d21.692e-3133.94calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.772e-3133.94calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.785e-3133.94calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.806e-3133.94calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.865e-3133.94calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P54289|CA2D1_HUMAN1.072e-3033.01Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q6PHS9|CA2D2_MOUSE1.184e-3033.94Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q8CFG6|CA2D2_RAT1.239e-3033.94Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q9NY47|CA2D2_HUMAN1.474e-3033.94Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|O08532|CA2D1_MOUSE6.853e-3032.54Voltage-dependent calcium channel subunit alpha-2/... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267GU031.936e-4944.70VWFA domain-containing protein (Fragment) OS=Macro... [more]
A0A267DMV84.705e-4845.61VWFA domain-containing protein OS=Macrostomum lign... [more]
A0A1S3JP645.861e-4540.54voltage-dependent calcium channel subunit alpha-2/... [more]
A0A2R2MM072.961e-4240.54voltage-dependent calcium channel subunit alpha-2/... [more]
A0A2T7NSC36.581e-4241.85VWFA domain-containing protein OS=Pomacea canalicu... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d2b6.951e-3435.48calcium channel, voltage-dependent, alpha 2/delta ... [more]
si:dkey-266j7.22.858e-3335.41calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2b1.912e-3235.48calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d34.132e-2731.98calcium channel, voltage dependent, alpha2/delta s... [more]
cacna2d2a5.832e-2731.66calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cacna2d1a2.608e-3233.33calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d4b1.929e-2829.91calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO299392.524e-1751.47Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO386782.953e-1543.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO482101.935e-927.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO299381.338e-846.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO482111.489e-830.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d2a3.295e-3333.64calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2a3.329e-3333.64calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2a3.360e-3333.64calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d1a1.216e-3233.49voltage-dependent calcium channel subunit alpha-2/... [more]
cacna2d2b5.770e-3233.49voltage-dependent calcium channel subunit alpha-2/... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000021966.17.672e-18091.38SMESG000021966.1[more]
SMESG000021966.11.205e-17991.38SMESG000021966.1[more]
SMESG000020648.13.973e-1526.50SMESG000020648.1[more]
SMESG000020648.14.833e-1526.50SMESG000020648.1[more]
SMESG000020648.15.591e-1526.50SMESG000020648.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000087 ID=SMED30000087|Name=Voltage-dependent calcium channel subunit alpha-2/delta-2|organism=Schmidtea mediterranea sexual|type=transcript|length=3017bp
AACTACATTAATTTTATTAACTTATAAAACCGAGTATTTAAGTAGCACAG
TAAATGATAAAATTCAATTTTTTTTCTAAATGGATTTTTCAAGATTTCTC
CTACTGATATTTCTGTCTTCCTTCATTAAGCAAATGAAAATGGATATATT
AAGTTCTTTGGAGAACCTCCAAATGGAATTCGATAAATTTATGCGAAATC
AATTTTCAGTATTCCAGGAACCTACAATCGCGAATATTTACATTGAAATC
GGTCAAAAAGGTGGAATTGAAACATTCCCAGTCAATCCATTAGAAATAGC
AAAAGACTTTTCTAACAAATTGGCCAACGAATTTCGCAAGAAAATGGAAT
CACTAAAAAGGGCAGTGGATTTCGCAGAAGAAGAAGCGACAAAATATCAA
TATGATCCTCATATCAAGCCAGAAGAGGTTCAATATATCAACTCGAAAGA
CCTGCCAGAAAATTCAGAATTGCTAGTCGATCATCCTCTATTCAAAACGA
GAGTTATAGCAAATCAGTCATCCGTGCATATTCCAACAGAGATTTATAAA
GAAGGAATTATAGTTCTAAATGCGTTAAAATGGACAGGAAATTTAGATAA
TATTTGGAAAAAGAATATTGAAATTGATCAAGATTTATTGTGGCAGTATT
TTGCATCACAAACAAGTCTTTTCAGAACATATCCAGGCAAGATTGATGTT
GTCAGTTCGTCCTGTATTTGTTCTTTTTATTTATTTCACATTCTTATTTC
ATTTTCTTATTCCGAAGGTCCGGTTCATTTATATTATATATTATTTATAT
AATTCAAATTTATATTAATTTATAATTTTTATGAAAATATTTTTCTGAGT
TTATAATAATATTTCTAGATTCCTTCATATTAAATACACTAAAATGGACA
CAAAAATTAAATAACATTTTCATCAGAGCATCCAATAATTTAAGATATCA
GTATTTTGCTTCTTTCACGGGAATTGTGCTACAGTATCCAGGTTTCGGTT
GATTGAGTTGATTTTACGCATGGCTCGTACAAATCTTTTTTCATCATTTG
AAAATAAACATTCAAACAAAATTTATATAATTTTTGATAAAAAATTGATG
AAATTAATTTTGCATGATAATTATTATTAGAATTGTTTGTTTGATGAAAT
AATTGTTCTATGTTATTTCATTATTTTATTTGGATGAAACATTTATAATG
TATTTTCTAATTTAAGAATATTTTATAATTAGGAATGAGATGGAGGAAAA
AAGGAACGGATATGTTTGATGTACGACGGAGACAATGGTATGTGCAAGGC
GCGTCATCTCCTAAAGACGTGATGGTTCTTATTGATACAAGCGGAAGTAT
GCATGGAATAGCAATTAAACTGACAAAATCAGCGGTGGAAAAACTAATAG
ATACGATGGGGGAAAATGATTATATTGCTGTTACCCATTTTCCTCCAGGG
AAAAACCAAGCAATGCAATTAATAAAGGACTACCCATTTATACAAACAAA
GCCTTGTTTTGCAACATTTGTGCAAGCCAGTAAACGAAATAAAGATCGCC
TCTTCAAACAAATATTCCAACTGAGAGCTCAAGGAATTGCCAATTTAGAC
ACTGCATTAGAATTTGCAATTAATGAATTCCATAAATTTGATAACCGCAC
TGAAAAAGGAAACGAGGGGGCCAACTGCAACAGACTGATTGTGGTGTTCA
CTGATAGCGGCGATGAGTACGATAAGGAAAAAATAAGATCATTAATGAAT
CGCTCGAACACCACGAAAAATTTAAGAATATTTATTTATTATGTCGGAGA
GGAAATCACGCCAATTGATGTGTTGGAAAATCGGACCTGTGAATACAGAG
GTTACTTCGGTCATATTCACGCAATGGGGGCCGTTTCAAATATAATAGAT
GTAAGAATTCTGTTGTGGTTGAATTTCTAGAAATAAAGTTGAGCATTGTA
ATTATACTAAATCTGATTGCAGAAGTATTCCAAAACGGTTCACTATCACA
CGATCCACAGAGAAAATCAAATGGAAGATAACGAATTTAGGATAGATTTA
GTATCAATAAATGAAGATGGATTTCATAATCCTGAGGATTTCCCACCTAT
GGTACGACTGGCATAAAATGCAAAGATGCCTGATTGTCTGCATCCATTAA
ATTAGTCTTGTTTACTGCCTGCATTTATATATTTATTTTTCTCGTTCTGG
AAATGAAACTAGGGACCTTCGTCTTTAACATTGCAAACCTTTTAAAATTA
CCTCTTTTTCCATTTTTCTTTTACCTTATATGGGTCGTGAATAGGTTTTC
GAAAGGTAATATTTGATTCCTGTTTAACAAGATTCGTACTTTTATAATTC
AAAATGATCTGACAACGGCAAATCGAATCCGTTCCTTGTTTTGACAACTG
TTGAGGTTACCATTACAAAATACATGTCCATGAGTCCCTTGAAGCTGTTG
CTCTCTTTTTTATTGCCATACGTCAAAAGGATTTTCGGTAAAAATAACAT
GCAAAACAAAAGCTCAAAATTAAGGCAAAACATTAAGTATATTATTCAAT
TAATATTGTTCAATTAAATATGGGGGTTTTCATCTGTTGGTGTGACATTG
AAATTCAAAAGGGTTTTTTTGAATTTCACTGTGTTAGTTGTTTCATTTAA
TTATTAATATTTTAATTCTGTAAATTTTATAAACAAATAATTCATAATTA
AGATTTAAAAAATTTTATAATCCAACTGAAATAAAAAACAAGCAAAAATA
GCCATTTGTACTATTAAATTTCAAGGTCACTCTAGTACAGTGGTTCCTAA
TCTTTTTAGAGTTCGGCGCCGCTTGAATGTAAAAATAATTTCTCTTACCC
TTTAAAAGGTAATAGATAAAATATAAAGTAATCAGAACAGAAATAGAAAA
TTTATTATATTTTATGAAAGTTACTGTATATTATGCGTTATATACTTATT
GTAAGTATATTTTTTTAGCAGTAACTGACTTGCCGATTTGAACGGATCTG
ACAGATGATTTTAAAAC
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protein sequence of SMED30000087-orf-1

>SMED30000087-orf-1 ID=SMED30000087-orf-1|Name=SMED30000087-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=241bp
MDFSRFLLLIFLSSFIKQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTI
ANIYIEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAE
EEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVH
IPTEIYKEGIIVLNALKWTGNLDNIWKKNIEIDQDLLWQYFASQTSLFRT
YPGKIDVVSSSCICSFYLFHILISFSYSEGPVHLYYILFI*
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protein sequence of SMED30000087-orf-2

>SMED30000087-orf-2 ID=SMED30000087-orf-2|Name=SMED30000087-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=232bp
MRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSA
VEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASK
RNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNR
LIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENR
TCEYRGYFGHIHAMGAVSNIIDVRILLWLNF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR013608VWA_N
IPR002035VWF_A
Vocabulary: molecular function
TermDefinition
GO:0005244voltage-gated ion channel activity
GO:0005245voltage-gated calcium channel activity
GO:0005262calcium channel activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0005891voltage-gated calcium channel complex
GO:0016020membrane
GO:0016021integral component of membrane
GO:0016529sarcoplasmic reticulum
GO:0030315T-tubule
GO:0070062extracellular exosome
GO:1990454L-type voltage-gated calcium channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006816calcium ion transport
GO:0034765regulation of ion transmembrane transport
GO:0051924regulation of calcium ion transport
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060402calcium ion transport into cytosol
GO:0061337cardiac conduction
GO:0061577calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070588calcium ion transmembrane transport
GO:0086002cardiac muscle cell action potential involved in contraction
GO:0086048membrane depolarization during bundle of His cell action potential
GO:0086091regulation of heart rate by cardiac conduction
GO:0098703calcium ion import across plasma membrane
GO:0098903regulation of membrane repolarization during action potential
GO:1901843positive regulation of high voltage-gated calcium channel activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 82..109
NoneNo IPR availablePANTHERPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDcoord: 51..203
NoneNo IPR availablePANTHERPTHR10166:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1coord: 51..203
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.523
IPR013608VWA N-terminalPFAMPF08399VWA_Ncoord: 99..203
e-value: 2.1E-23
score: 83.1