Degenerin unc-8

Overview
NameDegenerin unc-8
Smed IDSMED30000044
Length (bp)1693
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Degenerin unc-8 (SMED30000044) t-SNE clustered cells

Violin plots show distribution of expression levels for Degenerin unc-8 (SMED30000044) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Degenerin unc-8 (SMED30000044) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Degenerin unc-8 (SMED30000044) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30000044

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30000044SMESG000016391.1 dd_Smed_v4_44243_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30000044SMESG000016391.1 dd_Smed_v4_44243_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30000044SMESG000016391.1 dd_Smed_v4_44243_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Match: asic4b (acid-sensing (proton-gated) ion channel family member 4b [Source:NCBI gene;Acc:407667])

HSP 1 Score: 55.4546 bits (132), Expect = 1.182e-7
Identity = 69/270 (25.56%), Postives = 111/270 (41.11%), Query Frame = 2 
Query:  731 NSSYLHRSVFLYISNRNSFPRRNEIL--LAPGFNNIISLSQSRYE-LKGVQRKCR-NEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            N + L   + + I ++N  P  +++   ++PGF   +S  + R   L      CR + + V+  YD    S S    H   C+  + QR     CNC    +P      G   IC               KC+       Q            CE      C   +YG    KEL  V+  S           +  +R+L+ K+  +K  E +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G S++ + EI ++IY
Sbjct:  245 NETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTY--SVSACRLH---CESTQVQR----ECNCRMVHMP------GDADICAPSKI----------KCVDKALASLQKSTGD----SCPCE----TPCNLTRYG----KELSMVKIPS-----------RGSARYLSRKY--QKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIY 464
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Match: asic4a (acid-sensing (proton-gated) ion channel family member 4a [Source:NCBI gene;Acc:407668])

HSP 1 Score: 52.7582 bits (125), Expect = 5.987e-7
Identity = 27/77 (35.06%), Postives = 48/77 (62.34%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            K  +R+L+ K+D  + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G SV+ + EI +++Y
Sbjct:  194 KGSARYLSRKYDKSEDY--IRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVY 268
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Match: asic4a (acid-sensing (proton-gated) ion channel family member 4a [Source:NCBI gene;Acc:407668])

HSP 1 Score: 52.7582 bits (125), Expect = 8.508e-7
Identity = 27/77 (35.06%), Postives = 48/77 (62.34%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            K  +R+L+ K+D  + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G SV+ + EI +++Y
Sbjct:  386 KGSARYLSRKYDKSEDY--IRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVY 460
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Match: asic1c (acid-sensing (proton-gated) ion channel 1c [Source:NCBI gene;Acc:407670])

HSP 1 Score: 48.9062 bits (115), Expect = 6.570e-6
Identity = 30/94 (31.91%), Postives = 55/94 (58.51%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVN--LCGRTRKQQP 1570
            K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G SV+ + EIF+++Y  L +  L    RK++P
Sbjct:  104 KASAKYLAKKFNKTEQY--ITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRP 195
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Xenopus
Match: ASIC4 (acid sensing ion channel subunit family member 4 [Source:NCBI gene;Acc:100486325])

HSP 1 Score: 50.8322 bits (120), Expect = 4.167e-6
Identity = 30/94 (31.91%), Postives = 51/94 (54.26%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPIL 1576
            K  +R+L  K++  + +  +R+NF+ + I  E    +  +++  Y    LL DIGG MGL++G S + + EI +  Y+Y V  CG      P+L
Sbjct:  343 KGSARYLARKYNKNETY--IRENFLVLDIFFEALNYETIEQKKAYDLPSLLGDIGGQMGLFIGASFLTILEILD--YMYEVRGCGGAGSIGPVL 432
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Mouse
Match: Asic4 (acid-sensing (proton-gated) ion channel family member 4 [Source:MGI Symbol;Acc:MGI:2652846])

HSP 1 Score: 50.8322 bits (120), Expect = 3.427e-6
Identity = 24/77 (31.17%), Postives = 47/77 (61.04%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +  +R+L  K++  + +  +R+NF+ + +  E    +  +++  Y  S LL D+GG MGL++G S++ L EI ++IY
Sbjct:  392 RGSARYLARKYNRNETY--IRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIY 466
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Mouse
Match: Asic4 (acid-sensing (proton-gated) ion channel family member 4 [Source:MGI Symbol;Acc:MGI:2652846])

HSP 1 Score: 50.8322 bits (120), Expect = 3.569e-6
Identity = 24/77 (31.17%), Postives = 47/77 (61.04%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +  +R+L  K++  + +  +R+NF+ + +  E    +  +++  Y  S LL D+GG MGL++G S++ L EI ++IY
Sbjct:  373 RGSARYLARKYNRNETY--IRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIY 447
[Close]
BLAST of Degenerin unc-8 vs. UniProt/SwissProt
Match: sp|Q708S3|ASI4B_DANRE (Acid-sensing ion channel 4-B OS=Danio rerio OX=7955 GN=asic4b PE=2 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 8.926e-7
Identity = 69/270 (25.56%), Postives = 111/270 (41.11%), Query Frame = 2 
Query:  731 NSSYLHRSVFLYISNRNSFPRRNEIL--LAPGFNNIISLSQSRYE-LKGVQRKCR-NEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            N + L   + + I ++N  P  +++   ++PGF   +S  + R   L      CR + + V+  YD    S S    H   C+  + QR     CNC    +P      G   IC               KC+       Q            CE      C   +YG    KEL  V+  S           +  +R+L+ K+  +K  E +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G S++ + EI ++IY
Sbjct:  245 NETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTY--SVSACRLH---CESTQVQR----ECNCRMVHMP------GDADICAPSKI----------KCVDKALASLQKSTGD----SCPCE----TPCNLTRYG----KELSMVKIPS-----------RGSARYLSRKY--QKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIY 464
[Close]
BLAST of Degenerin unc-8 vs. UniProt/SwissProt
Match: sp|Q708S4|ASI4A_DANRE (Acid-sensing ion channel 4-A OS=Danio rerio OX=7955 GN=asic4a PE=2 SV=1)

HSP 1 Score: 52.7582 bits (125), Expect = 6.045e-6
Identity = 27/77 (35.06%), Postives = 48/77 (62.34%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            K  +R+L+ K+D  + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G SV+ + EI +++Y
Sbjct:  386 KGSARYLSRKYDKSEDY--IRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVY 460
[Close]
BLAST of Degenerin unc-8 vs. TrEMBL
Match: S5W2R2 (Asic OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 494.582 bits (1272), Expect = 1.498e-167
Identity = 251/497 (50.50%), Postives = 353/497 (71.03%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFEN---FHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKK-YSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            MI+++QSSTIHG+ HI  A ++I K+LW ILF++G+I I VNIVF+ M++ SNPV+IS   +HEPFIWPDITFC PT PY F  NSQPY HW E   +T+R+  +++ +T   ++++ +R  DYELEERTIAMSSADP KL+   F  ++  I +  I+ +       EF  +    +ED K LFT+Q+VQ+ NNIPC TFH+D+S+ + Q  IKS+ F  K N ESY +FNSSY  +S+FLYISN++  P+ NEI+L PG+NN++ L+Q+R+   G++R CRNEK+  ELYD+LL+ST  + G YDDCK++ SQ+ +V+ CNCY+ FLPI+KN +G PR+CLN + +SE E+L+NAKCM++ FR++          ++ C+ YR I C +V Y I+  KE+ V+ WS  TN RR+ +IK  Y +       +  + E+++DN + + I R+ + GDLYKEE EYPFSELLSD+GGLMGLWLG+SV+GLFEI EF+Y
Sbjct:    1 MIDLIQSSTIHGIGHIFSATNKIFKVLWCILFLVGVIAIIVNIVFISMKFLSNPVIISYTFEHEPFIWPDITFCNPTDPYAFTINSQPYLHWIETLNKTKRVAGKVARQTSMSQLIHSRRENDYELEERTIAMSSADPAKLQATAFQNYLYRIGY--IKAHKGLYFSKEFQSSSTKLNEDWKSLFTSQIVQMRNNIPCHTFHLDKSRIVKQKFIKSLLFRFKLNEESYKIFNSSYTFQSMFLYISNKDEIPQSNEIILTPGYNNVVQLTQNRHSYTGLRRTCRNEKFEAELYDSLLQSTEKYSGSYDDCKKIVSQQKYVKYCNCYNSFLPIFKNSSGFPRLCLNASIFSEAEVLKNAKCMINTFRKYAESDKARRRFYNRCKMYRPIPCNKVLYKIDHRKEILVDLWSKSTNDRRREIIKTLYLKTFQTNETSLDFVEKVKDNIMQLIINRDNESGDLYKEEREYPFSELLSDVGGLMGLWLGLSVIGLFEIVEFVY 495
[Close]
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A183A5V1 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS2336 PE=3 SV=1)

HSP 1 Score: 283.108 bits (723), Expect = 7.017e-83
Identity = 178/538 (33.09%), Postives = 285/538 (52.97%), Query Frame = 2 
Query:   56 ILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKP---LFTTQLVQIGNNIPCFTFHIDRSKFINQN---SIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPI-----YKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSN-CEHYRFI-KCKEVKYGIEK-EKELFVEFWSGLTNQRRQRLIKK-----YSRHLTEK---------FDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPILEKC 1585
            +L+ ST+HG+SH+  A SRI + +W+IL++ G+ G F N+ F++ RY + PVL S   DHE FIWPDIT C P APY  V        W E+  R  R+ + +S E  F  I + ++    E+  + +  S+  P +  +      I  +  ++ R+  +     E +  F +   P    F  Q++Q  +NIPC+T  +  +  ++Q    S   V+  LKFN +S+ + NSSY  R++ L+IS    FP    + L  G+ + +S+S +R+  +  +  CR +++V +++DA LK+     G  D C ++ SQRL++ NC CYSPFLP      +    GQP +C N + ++   I QNAKCM DV+ ++  +  +MN+  +  CE +R    C+   Y  E   +   +E WS   N+ R   +       +   L E+          +N   F  MR+NF  + I R+  +G L  EE EYP SELLSD+GGLMGLW+G+SV+GLFE+ E +    +++         ++E+C
Sbjct:   33 LLEHSTVHGLSHVSTASSRIGRSIWLILWLAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHESFIWPDITLCNPMAPYP-VHLRNRTEKWNELRLRATRVAKNIS-EDLFAAIDDAEQ---LEIAIQALLYSTISPEQFGVGEPQELIQFVAADKGRSGIHLTV--EMYSTFTDLDAPKTQYFHAQMLQKRHNIPCYTLQL--AHVLSQEDCLSTNQVSLGLKFNHDSFLIINSSYAPRNIDLFISLPGHFPEDESMELLSGYTHKVSVSMTRFIREPNRLPCRTDEFVAQMFDANLKTRREIVGSADFCHKLVSQRLYINNCGCYSPFLPYPVVDEHLLVHGQPVLCFNMSHFNITSIDQNAKCMYDVYTQYHDHSVYMNLPEAQYCETFRSTPPCESTSYMPESLRRTPIIELWSDTINEGRTAFLTSTFESVFGPDLPEERIRQLLNNSGNNSNMFTYMRNNFGMVTISRKFPRGTLTHEELEYPLSELLSDLGGLMGLWIGISVIGLFEVVELLAFVSLSMISA------LIERC 555
[Close]
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A4E0RSD9 (Degenerin unc-8 OS=Fasciola hepatica OX=6192 GN=D915_000009 PE=3 SV=1)

HSP 1 Score: 265.388 bits (677), Expect = 5.773e-76
Identity = 171/546 (31.32%), Postives = 286/546 (52.38%), Query Frame = 2 
Query:   56 ILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAM---SSADPYKLKMDNFSYHIMLIVFNRIRTYTNY-ISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQN---SIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFL---------PIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSN-CEHYRFI-KCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKK-----YSRHLTEK---------FDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEI---FEFIYLYLVNLCGRTRKQQPILEKC 1585
            +L+ ST+HG+SH+  A +RI + +W+IL++ G+ G F N+ F++ RY + PVL S   DHE FIWPDIT C P APY    N++    W  + +    +   +S     F  ++     + E EE T+     S+  P +   ++    +  +  ++ +T  +  I  +  F N        F  Q++Q   NIPC+T  +D  + +N+    S K V+  LKFN +S  + NSSY   ++ L+IS     P    + +  G+++ ++++  R+  +  +  CR E++V +++DA LK+     G  D C ++ SQRL++ +C CYSPFL         P+Y+    QP +C N + ++   I +NA+CM DV+ +F+    +MN+  +  CE +R    C+ + Y +E  +    +EFW+   N+ R   +       + + L E+          +       MR+NF  + I R+  +G L  EE EYP SELLSD+GGLMGLW+G+SV+GLFE+   F F+ L +++          +LE+C
Sbjct:   34 LLEHSTVHGLSHVSTAGTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNR-SEKWNLLHQLATAVSRNISGN--LFATID-----EAEQEEVTVQALIHSTVSPMEFGANDPHELVHFVAVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLD--QVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQ----QPVLCFNMSHFNASGIDRNARCMYDVYTQFKEDFVYMNLPEAGYCETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELFAFVGLTVISA---------LLERC 556
[Close]
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A5J4NUF1 (Uncharacterized protein OS=Paragonimus westermani OX=34504 GN=DEA37_0013022 PE=3 SV=1)

HSP 1 Score: 260.381 bits (664), Expect = 1.893e-74
Identity = 170/545 (31.19%), Postives = 279/545 (51.19%), Query Frame = 2 
Query:   35 FNRNMIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFN---RIRTYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRS-KFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLP---IYKNK--TGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSN-CEHYRFIKCKEVKYGIEK-EKELFVEFWSGLTNQRRQRLIKKYSRHL----------------TEKFDN-------KKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEF-------IYLYLVNLC 1546
            F+  +  +L+ ST+HG+SH+  A +++ ++ W  L + G+ G F N+ F+I RY + PVL S   ++E FIWPDIT C   APY    + +    W  +  +     ++L N + F  I +  +N   E+  + +  S+  P +  +      I  +  +   +    T  IS N    + +  LK  F TQ++Q   N+PC+T  +  S   +  N + S+   +KFN+ESY + NSSY    + L+IS+    P  + I + PG+   +SL  SR   +  +  CR + Y  E++D  L +     G    C R+ SQ L++ +C+CYSPFLP   +Y +K  +    +C N + +S  +I +NA CM+ ++ R+Q    + ++  +  CE +R   C +V+Y +    +   VE WS   N+ R   +    ++L                  K DN        K  + MRDNF  +++ R+++ G+L +EE EYP SEL+SD+GGLMGLW+G+SV+GLFEI E           +LV+LC
Sbjct:   23 FHVGVERLLEHSTVHGLSHVSTAATKLGRITWFCLLLAGIAGFFTNLSFIIDRYLTRPVLTSYISEYEGFIWPDITLCNAMAPYSLHLHGR-IPKWQALRNQASAFAQKL-NSSLFASIDSQDQN---EIAIQALMYSTLSPPEYGVGEPEEFIQFVATDVGYQGIILTVEISGN--MTHLNPPLKKYFHTQVLQKRYNVPCYTLQLRHSLTAVQSNQVNSIGLGVKFNVESYRIINSSYASPYIDLFISHPGHAPHDDPIEMLPGYTLSLSLRMSRLRREPARLSCRTDFYTTEVFDPDLVTKRRVNGSATFCHRIVSQHLYLNSCHCYSPFLPYPVVYNHKLFSKMAILCFNMSRFSVAQINRNADCMLRIYERYQLSSVYNSVPEARACEQFRKPLCDDVEYKLSDIRRTAMVELWSNSYNEARIAFLTSSFQNLFSSDIPPEQLVSWLDSDTKDDNTKDNDSMPKILKYMRDNFGLLSVNRKSELGELVREELEYPLSELMSDVGGLMGLWIGISVIGLFEIVELCGFAIMTAVAWLVDLC 560
[Close]
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A504YRR8 (Degenerin unc-8 OS=Fasciola gigantica OX=46835 GN=FGIG_05554 PE=3 SV=1)

HSP 1 Score: 261.151 bits (666), Expect = 2.107e-74
Identity = 169/546 (30.95%), Postives = 286/546 (52.38%), Query Frame = 2 
Query:   56 ILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAM---SSADPYKLKMDNFSYHIMLIVFNRIRTYTNY-ISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQN---SIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFL---------PIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSN-CEHYRFI-KCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKK-----YSRHLTEK---------FDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEI---FEFIYLYLVNLCGRTRKQQPILEKC 1585
            +L+ ST+HG+SH+  A +RI + +W+IL++ G+ G F N+ F++ RY + PVL S   DHE FIWPDIT C P APY    N++    W  + +    +   +S     F  ++     + E EE T+     S+  P +   ++    +  +  ++ +T  +  I  +  F N        F  Q++Q   NIPC+T  +D  + +N+    S K V+  LKFN +S  + NSSY   ++ L+IS     P    + +  G+++ ++++  R+  +  +  CR E++V +++DA LK+     G  D C ++ SQRL++ +C CYSPFL         P+Y++    P +C N + ++   I +NA+CM +V+ +F+    +MN+  +  CE +R    C+ + Y +E  +    +EFW+   N+ R   +       + + L E+          +       MR+NF  + I R+  +G L  EE EYP SELLSD+GGLMGLW+G+SV+GLFE+   F F+ L +++          +LE+C
Sbjct:   34 LLEHSTVHGLSHVSTASTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNR-SEKWNLLHQLATAVSRNISGN--LFATID-----EAEQEEVTVQALIHSTVSPMEFGANDPHELVHFVAVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLD--QVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQH----PVLCFNMSHFNASGIDRNARCMYEVYTQFKEDFIYMNLPEAGFCETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELFAFVGLTVISA---------LLERC 556
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Match: asic4b (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103044180])

HSP 1 Score: 54.299 bits (129), Expect = 2.557e-7
Identity = 67/270 (24.81%), Postives = 111/270 (41.11%), Query Frame = 2 
Query:  731 NSSYLHRSVFLYISNRNSFPRRNEIL--LAPGFNNIISLSQSRYE-LKGVQRKCR-NEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            N + L   + + I +++  P  +++   ++PGF   +S  + R   L      CR + + V+  YD    S S    H   C+ ++ QR     CNC    +P      G   IC               KC+       Q            CE      C   +YG    KEL  V+  S           K  +R+L+ K+   + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G S++ + EI ++IY
Sbjct:  248 NETTLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQRLSYLPQPWGNCRASTEPVIPGYDTY--SVSACRLH---CESIQVQR----ECNCRMIHMP------GSADICTPA----------KVKCVDRALGLLQKSTGD----SCPCE----TPCNVTRYG----KELSMVKIPS-----------KGSARYLSRKYHTTEDY--IRDNFLILDIYFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIY 467
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Match: ENSAMXT00000038299.1 (acid-sensing ion channel 1 [Source:NCBI gene;Acc:103026179])

HSP 1 Score: 53.1434 bits (126), Expect = 5.129e-7
Identity = 58/242 (23.97%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +APGF   +S  + R   L      CR+     + +     +T +      DC+     R  V NCNC    +P             +  + + E+  + A   +D +  R   Y          CE      C   +YG    KEL FV+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G S++ + E+F+++Y
Sbjct:  272 VAPGFQTFVSCQEQRLTYLPPPWGDCRDAPMDSDFF-----TTYSITACRIDCE----TRYLVENCNCRMVHMPG------------DAPYCTPEQYKECADPALDFLVERDNDYCV--------CE----TPCNMTRYG----KELSFVKIPS-----------KASAKYLAKKFNKSEQY--ISDNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYLY 463
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Match: ENSAMXT00000047165.1 (acid-sensing ion channel 1 [Source:NCBI gene;Acc:103026179])

HSP 1 Score: 52.373 bits (124), Expect = 9.776e-7
Identity = 58/242 (23.97%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +APGF   +S  + R   L      CR+     + +     +T +      DC+     R  V NCNC    +P             +  + + E+  + A   +D +  R   Y          CE      C   +YG    KEL FV+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G S++ + E+F+++Y
Sbjct:  300 VAPGFQTFVSCQEQRLTYLPPPWGDCRDAPMDSDFF-----TTYSITACRIDCE----TRYLVENCNCRMVHMPG------------DAPYCTPEQYKECADPALDFLVERDNDYCV--------CE----TPCNMTRYG----KELSFVKIPS-----------KASAKYLAKKFNKSEQY--ISDNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYLY 491
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544])

HSP 1 Score: 51.6026 bits (122), Expect = 1.409e-6
Identity = 62/260 (23.85%), Postives = 106/260 (40.77%), Query Frame = 2 
Query:  755 VFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            V L+  +   FP      + PGF   +S  + R + L      C++     E +     ST +      DC+     R  + NCNC    +P      G   +C      + E+    A   +D +  +   Y          C+      C   +YG    KEL  V+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G SV+ + EIF+++Y
Sbjct:  248 VQLHSQSEPPFPNELGFWVTPGFQTFVSTQEQRLQYLPPPWGDCKSTPIDSEFF-----STYSITACRIDCE----TRYLLENCNCRMVHMP------GTSTVC------TPEQYKDCADPALDFLVEKDNDYCV--------CQ----TPCNMTRYG----KELSMVKIPS-----------KASAKYLAKKFNKTEQY--IGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLY 457
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Match: asic4a (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103040152])

HSP 1 Score: 50.0618 bits (118), Expect = 5.138e-6
Identity = 31/103 (30.10%), Postives = 58/103 (56.31%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPILEKCEINPAS 1603
            K  +R+L+ K+   + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G S++ + EI ++IY  +     + R Q+ +  + + NP S
Sbjct:  389 KGSARYLSRKYHKSEDY--IRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYIYEVV-----KRRLQRALKPQKDQNPPS 484
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 48.521 bits (114), Expect = 3.023e-6
Identity = 22/57 (38.60%), Postives = 35/57 (61.40%), Query Frame = 2 
Query: 1352 MRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFI 1522
            MR+N + I +        L +++   P S LLSDIGG +GL++G SV+ + E+ EF+
Sbjct:  384 MRENLLSIDVAYTDLNYALIQQQKTLPESVLLSDIGGQLGLFVGASVITIIEVLEFV 440
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 48.521 bits (114), Expect = 3.427e-6
Identity = 22/57 (38.60%), Postives = 35/57 (61.40%), Query Frame = 2 
Query: 1352 MRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFI 1522
            MR+N + I +        L +++   P S LLSDIGG +GL++G SV+ + E+ EF+
Sbjct:  394 MRENLLSIDVAYTDLNYALIQQQKTLPESVLLSDIGGQLGLFVGASVITIIEVLEFV 450
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696])

HSP 1 Score: 47.3654 bits (111), Expect = 7.107e-6
Identity = 64/256 (25.00%), Postives = 106/256 (41.41%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRY-ELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQ 1567
            +APGF   +S  + R   L      C+ +    + +D     T +      DC+     R  V NCNC    +P      G    C      + E+  + A   +D +  +  +Y          C+      C   +YG    KEL  V+  S       + L KKY++  TE +  +     + D F   A+  ET      +++  Y  + LL DIGG MGL++G S++ + EIF+++Y  L +   + RK+ 
Sbjct:  281 VAPGFQTFVSCQEQRLIYLPSPWGDCKADPINSDFFD-----TYSITACRIDCE----TRYVVENCNCRMVHMP------GDAPYC------TPEQYKECADPALDFLVEKDNNYCV--------CD----TPCNTTRYG----KELSMVKIPS---KASAKYLAKKYNK--TEDYIRENVL--VLDIFFEAALNYET-----IEQKKAYEVAGLLGDIGGQMGLFIGASILTILEIFDYLYEVLKDKVCKCRKKH 487
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO39446 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA83])

HSP 1 Score: 55.4546 bits (132), Expect = 3.557e-8
Identity = 67/316 (21.20%), Postives = 133/316 (42.09%), Query Frame = 2 
Query:  629 CFTFHIDR--SKFINQNSIKSVNFNLKFNL---ESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRK-----CRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVE--FWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVN 1540
            C+TF+  +  S FI+ ++  +   ++  +    E Y L++S+     V ++  +   +  ++   + PGF+  + L+  R E+  ++        R+  Y  + Y  L++        Y D        + V+ C C+   +     +TG    C      S ++I     C+    RRFQ           +C     ++C  V++ ++     +    FW  ++N+R   +            D KK+ E  R   I + +  +    ++ KE+  Y  S+L  D GG MGL+LG S++ + E  + + +YLV+
Sbjct:  183 CYTFNSGKRESAFISHDTGPTSGLSITLDAQPEEYYSLYSSTGTGFRVIVHDQSEFPWVEKHGWEIPPGFSTNVRLA--RKEISSLESPYNSNCSRDTNYASQSY-CLVQC-------YSD--------MVVKRCGCH---MLGMTEETGHTPWC------SPQQI---KACVYTTSRRFQPNMC-------SCP----VRCSRVEFDVQLSSLYYPPDNFWETISNERSLTIYAN---------DTKKFQEWYRRRVIQLNVFYKELTTEVRKEKEAYTISDLAGDFGGNMGLFLGCSILTIAEFIDLLVVYLVH 448
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2])

HSP 1 Score: 53.5286 bits (127), Expect = 1.617e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 2 
Query: 1406 LYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRK 1561
            L +E   Y F  LLSDIGG MG+W+G+S +   E+ E + + L N+  R++K
Sbjct:  447 LVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVILANMSNRSKK 498
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO36191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJB5])

HSP 1 Score: 52.7582 bits (125), Expect = 2.698e-7
Identity = 31/107 (28.97%), Postives = 52/107 (48.60%), Query Frame = 2 
Query: 1256 WSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY---LYLVN-LCGRTRKQ 1564
            WS    +  QRL++K  R    K ++      +R NF+ + +  E    +       YP   LL D+GG +GLW+G+SV+   E  + +     YL + + G+T+ Q
Sbjct:  366 WSDSYEKTFQRLVRKSDRGFANKMNDASI---LRKNFLRVKLYYEELNRETITYSLSYPVENLLGDVGGQLGLWIGVSVITCAEFLKLLVDLAWYLASKMSGKTKTQ 469
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Medaka
Match: ENSORLT00000031246.1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423])

HSP 1 Score: 50.8322 bits (120), Expect = 2.792e-6
Identity = 59/242 (24.38%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +APGF   +S  + R   L      C++     + +++   +         DC+     R  V NCNC    +P      G    C      S E+  + A   +D +  R   Y          CE      C   +YG    KEL FV+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G S++ + E+F+++Y
Sbjct:  265 VAPGFQTFVSCQEQRLTYLPPPWGDCKSTPMDSDFFNSYSITACRI-----DCE----TRYLVENCNCRMVHMP------GDAPYC------SPEQYKECADPALDFLVERDNDYCV--------CE----TPCNLTRYG----KELSFVKIPS-----------KASAKYLAKKFNKTEQY--IADNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTVLELFDYLY 456
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Medaka
Match: asic4a (acid sensing ion channel subunit family member 4 [Source:NCBI gene;Acc:101159336])

HSP 1 Score: 50.447 bits (119), Expect = 3.499e-6
Identity = 25/77 (32.47%), Postives = 48/77 (62.34%), Query Frame = 2 
Query: 1295 KKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            K  +R+L+ K+D  + +  +RDNF+ + I  E    +  +++  Y  + LL DIGG MGL++G S++ + EI ++++
Sbjct:  386 KGSARYLSRKYDKSEDY--IRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYVF 460
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Medaka
Match: ENSORLT00000008662.2 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423])

HSP 1 Score: 50.447 bits (119), Expect = 4.233e-6
Identity = 57/242 (23.55%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +APGF   +S  + R   L      C++     + +++   +         DC+     R  V NCNC    +P             +  + S E+  + A   +D +  R   Y          CE      C   +YG    KEL FV+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G S++ + E+F+++Y
Sbjct:  282 VAPGFQTFVSCQEQRLTYLPPPWGDCKSTPMDSDFFNSYSITACRI-----DCE----TRYLVENCNCRMVHMPG------------DAPYCSPEQYKECADPALDFLVERDNDYCV--------CE----TPCNLTRYG----KELSFVKIPS-----------KASAKYLAKKFNKTEQY--IADNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTVLELFDYLY 473
[Close]
BLAST of Degenerin unc-8 vs. Ensembl Medaka
Match: ENSORLT00000031708.1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423])

HSP 1 Score: 50.0618 bits (118), Expect = 4.690e-6
Identity = 59/242 (24.38%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  809 LAPGFNNIISLSQSRYE-LKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVD-VFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKEL-FVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIY 1525
            +APGF   +S  + R   L      C++     + +++   +         DC+     R  V NCNC    +P      G    C      S E+  + A   +D +  R   Y          CE      C   +YG    KEL FV+  S           K  +++L +KF+  + +  + DN + + I  E    +  +++  Y  + LL DIGG MGL++G S++ + E+F+++Y
Sbjct:  299 VAPGFQTFVSCQEQRLTYLPPPWGDCKSTPMDSDFFNSYSITACRI-----DCE----TRYLVENCNCRMVHMP------GDAPYC------SPEQYKECADPALDFLVERDNDYCV--------CE----TPCNLTRYG----KELSFVKIPS-----------KASAKYLAKKFNKTEQY--IADNILVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTVLELFDYLY 490
[Close]
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000016391.1 (SMESG000016391.1)

HSP 1 Score: 844.343 bits (2180), Expect = 0.000e+0
Identity = 423/484 (87.40%), Postives = 450/484 (92.98%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIR--TYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSV 1492
            MIE+++SSTIHGVSHIH AKS+I K+LWI LFI G+IGIF+NI F++++YFSNPVL S  L+HEPFIWPD+TFCKPTAP+YF ENSQ YNHW EV  +T+RIVERL+NET+ FKI+ GK NTDYELEERTIAMSSADPYKLK+D+F  H++ I FN+I+   Y N     +   +  EDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSV
Sbjct:    1 MIELIESSTIHGVSHIHSAKSQIIKLLWIFLFIFGIIGIFINIAFILIKYFSNPVLFSHILNHEPFIWPDMTFCKPTAPFYFGENSQAYNHWAEVVSKTKRIVERLANETKVFKIIIGKNNTDYELEERTIAMSSADPYKLKVDDFQSHVIGINFNKIQEGIYYNVDYSVKAVTSIDEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSV 484
[Close]
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000017678.1 (SMESG000017678.1)

HSP 1 Score: 806.209 bits (2081), Expect = 0.000e+0
Identity = 405/523 (77.44%), Postives = 446/523 (85.28%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFE--NFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPILEKCEINPASPL 1609
            MIEILQSSTIHGVSHIHGAKS+ITK+LWI LFI G+IGIFVNIVFVI++YFSNPVLIS  LDHEPFIWPD+TFCKPTAPYYF ENSQ Y HW+ VF RTRRIVERL+NETE FKI+NGKRNTDYELEERTIAMSSADPYKLK ++F YHIM I FN+++    Y  DN      +F EDLKPLFT  LVQI NNIPCFTFHID+SKF+NQN IKS++F LKFNLESY LFNSSYLHRSVFLYI+NRN  P +NEILLAPGFNNI+SLSQSRYE +GV RKCRN+ +  ELYD LL+STSTFEGHYDDCK+VESQ+LFV  C CYSPFLPIYKN+TG PRICLN TFYSE+EI++NAKCM DV+ +FQSYKAF N     C+ YRFIKC EVKY IEK+KELFVEFWSGLTNQRR  L+KK S +L EKFD K YFERMRDNFIGI I RE QKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFE +YLYL NLC +T KQQ  +EK E N ASPL
Sbjct:    1 MIEILQSSTIHGVSHIHGAKSQITKVLWIFLFIFGIIGIFVNIVFVIIKYFSNPVLISHKLDHEPFIWPDVTFCKPTAPYYFGENSQAYTHWSHVFWRTRRIVERLANETEVFKIINGKRNTDYELEERTIAMSSADPYKLKTNDFRYHIMAIYFNKMQRGIYYHIDNSGIAVTSFAEDLKPLFTAPLVQIRNNIPCFTFHIDKSKFLNQNQIKSISFYLKFNLESYLLFNSSYLHRSVFLYITNRNGIPHKNEILLAPGFNNIVSLSQSRYEYRGVLRKCRNKIFETELYDGLLQSTSTFEGHYDDCKKVESQKLFVGICKCYSPFLPIYKNETGPPRICLNATFYSEDEIVRNAKCMTDVYTKFQSYKAFRNHYRLKCQDYRFIKCNEVKYKIEKDKELFVEFWSGLTNQRRNELLKKVSYYLMEKFDIKNYFERMRDNFIGITINREFQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFELMYLYLKNLCYQTSKQQSNMEKFEQNAASPL 523
[Close]
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000069546.1 (SMESG000069546.1)

HSP 1 Score: 799.275 bits (2063), Expect = 0.000e+0
Identity = 403/521 (77.35%), Postives = 452/521 (86.76%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPILEKCEINPASPL 1609
            MIEILQSSTIHGVSHIHGAKSRITKMLWIILFILGLIGIFVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFT  LVQI NNIPCFTFHI++SK ++Q++I S+ F+L FN++SY LFNSS+LHRSVFLYI+NRN  P++ E+LL PGFNNI+SLSQ+R+E +GVQRKCRN+ Y VELYDALL+STS FEG+Y DC +VESQ+L V NC CY+PFLPIYKN+TG PRICLN TFYSEEEIL+NAKCMV+  R+F+S+  +    +  C+ Y+ IKC EVKY IEKEK LF E  SG T QRR+++IK +S+   ++ DN+  FER+RDN+I I IKRE  KGDLYKEEYEYPFS+LLSDIGGLMGLWLGMSVVGLFEIFE IY+Y  NL     K+Q  +  CE N AS L
Sbjct:    1 MIEILQSSTIHGVSHIHGAKSRITKMLWIILFILGLIGIFVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTAPLVQIQNNIPCFTFHINKSKSLHQDNITSIRFHLNFNIKSYMLFNSSFLHRSVFLYITNRNGIPQKYEMLLEPGFNNIVSLSQNRFEYRGVQRKCRNKTYKVELYDALLQSTSIFEGYYADCMKVESQKLCVSNCKCYNPFLPIYKNETGSPRICLNATFYSEEEILKNAKCMVNRLRKFKSFFLYRRFFNPKCQDYQLIKCNEVKYKIEKEKLLFAELSSGFTTQRRRKVIKGFSKWF-QRIDNRSDFERIRDNYIVITIKREFPKGDLYKEEYEYPFSQLLSDIGGLMGLWLGMSVVGLFEIFEIIYMYFTNL----NKKQSNIRICEQNAASLL 516
[Close]
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000017668.1 (SMESG000017668.1)

HSP 1 Score: 729.554 bits (1882), Expect = 0.000e+0
Identity = 368/522 (70.50%), Postives = 425/522 (81.42%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNI-PCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLCGRTRKQQPILEKCEINPASPL 1609
            MIEILQSSTIHGVSHI GAKSRITKMLWII+FILG+I IFVNIVFVIM+YFSNPVLIS  LDHEPFIWPDITFCKPTAPYYFVENSQ YNHWTEVFRRTRRI+ERL+NETE F I+  + NTDYELEERTIAMSSADPYKLK++N+ YHI  I F RI  Y NY ++ E  E F EDL  LFT+ LVQI NN+ PCFTFH+D+SK +NQN IKS  F+L  N++SY LFNSS  HRSVFLYI+NRN  P+  E+LL PGFNNIISLSQ+RYE +GV RKCR + Y VELYDALL+STSTFEG YDDC++VE+Q+LFV  CNCYSPFLPIYKNKTG PRICLN TFYSEE++L+NA CMV+ FR+ +S +AF N+    C+ Y+ I+C +VKY  EKEK LF E WSG T +RR +++K++S    ++ DN+  FER+RDN+I I I RE  KGDLYKEEYEYPFS+LLSDIGGLMGLWLGMSVVGLFEIFE IYLYL+ L     K Q  +EKCE N ASPL
Sbjct:    1 MIEILQSSTIHGVSHIQGAKSRITKMLWIIIFILGIILIFVNIVFVIMKYFSNPVLISHKLDHEPFIWPDITFCKPTAPYYFVENSQIYNHWTEVFRRTRRILERLTNETEAFSIITKQINTDYELEERTIAMSSADPYKLKVNNYRYHIKGITFLRIPRYVNYYANTEVMEFFEEDLMSLFTSPLVQIHNNMFPCFTFHVDKSKSLNQNYIKSFFFHLNLNIKSYLLFNSSAFHRSVFLYITNRNGIPQTYEMLLEPGFNNIISLSQTRYEYRGVHRKCRKKTYEVELYDALLQSTSTFEGDYDDCRKVETQKLFVSKCNCYSPFLPIYKNKTGPPRICLNATFYSEEDVLKNANCMVNNFRKIESVEAFRNLYRLKCQDYKLIECNKVKYKFEKEKLLFTELWSGFTTKRRHKMLKQFSNWF-QRIDNRSDFERIRDNYIVITINREFPKGDLYKEEYEYPFSQLLSDIGGLMGLWLGMSVVGLFEIFEIIYLYLIKLS----KHQTNMEKCEQNDASPL 517
[Close]
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000017657.1 (SMESG000017657.1)

HSP 1 Score: 535.798 bits (1379), Expect = 0.000e+0
Identity = 277/499 (55.51%), Postives = 360/499 (72.14%), Query Frame = 2 
Query:   47 MIEILQSSTIHGVSHIHGAKSRITKMLWXXXXXXXXXXXXVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHIDRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRRNEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFEGHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEILQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELFVEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNL 1543
            M E+L+SSTIH VSHI+GAKSR TK+LW  +FI G+IGI VNIV+VI  YFS+P+L+S  L+ E FIWPDIT CKP AP+YF ++S  Y +W E++R+T ++V RL+NETE  K++    + D E EERT+ MS+ADP KLK D+   H+  I +N      N+  D+ F +    DLK  FTTQ VQI NNIPCFTF I+++K I +N +  + F LKFN +SY LFNSSY   SVFL+++N N  P+   + L P +N+IISLSQSRY  K ++ KCR E Y VELYD  L+S S FEG++ DCK+V+SQ +FV  C CYSPFLPIYKN TG PRICLN T YSE+EI+QNA CMVD ++RF       N  +S+CE YR  KC E++Y + KEKELF EF++G +N+RR+++IK      T++  ++  +  +RDNF+ + I RET+KGDL+KEE+EY   ELLSDIGGLMGLWLGMS+VGLFEIFE  YLYL+NL
Sbjct:    2 MDELLESSTIHVVSHIYGAKSRYTKVLWSFVFIFGIIGISVNIVYVINNYFSSPILLSHTLNSEEFIWPDITLCKPVAPFYFEKDSDTYKYWMEIYRKTSKVVRRLANETEVLKLIGMIGDGDSEFEERTVMMSTADPLKLKTDDIRNHLFSIYYNE-----NHKGDSGFGD--VTDLKSAFTTQYVQIFNNIPCFTFQINKTKIIQKNLVFLL-FYLKFNFDSYLLFNSSYSPPSVFLFLNNANEIPQSKAMTLIPSYNHIISLSQSRYIYKNIKEKCREEIYYVELYDVTLQSYSKFEGNFVDCKKVKSQEMFVSQCKCYSPFLPIYKNATGPPRICLNATLYSEDEIIQNAYCMVDAYKRF-------NENNSSCEIYRLAKCDEIRYKMGKEKELFTEFFNGNSNERRRKMIKIIFSQFTQQPVSEIPYNIIRDNFMQLKISRETEKGDLFKEEFEYRMFELLSDIGGLMGLWLGMSIVGLFEIFEITYLYLINL 485
The following BLAST results are available for this feature:
BLAST of Degenerin unc-8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
asic4b1.182e-725.56acid-sensing (proton-gated) ion channel family mem... [more]
asic4a5.987e-735.06acid-sensing (proton-gated) ion channel family mem... [more]
asic4a8.508e-735.06acid-sensing (proton-gated) ion channel family mem... [more]
asic1c6.570e-631.91acid-sensing (proton-gated) ion channel 1c [Source... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ASIC44.167e-631.91acid sensing ion channel subunit family member 4 [... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Asic43.427e-631.17acid-sensing (proton-gated) ion channel family mem... [more]
Asic43.569e-631.17acid-sensing (proton-gated) ion channel family mem... [more]
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BLAST of Degenerin unc-8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q708S3|ASI4B_DANRE8.926e-725.56Acid-sensing ion channel 4-B OS=Danio rerio OX=795... [more]
sp|Q708S4|ASI4A_DANRE6.045e-635.06Acid-sensing ion channel 4-A OS=Danio rerio OX=795... [more]
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BLAST of Degenerin unc-8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
S5W2R21.498e-16750.50Asic OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A183A5V17.017e-8333.09Uncharacterized protein OS=Echinostoma caproni OX=... [more]
A0A4E0RSD95.773e-7631.32Degenerin unc-8 OS=Fasciola hepatica OX=6192 GN=D9... [more]
A0A5J4NUF11.893e-7431.19Uncharacterized protein OS=Paragonimus westermani ... [more]
A0A504YRR82.107e-7430.95Degenerin unc-8 OS=Fasciola gigantica OX=46835 GN=... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic4b2.557e-724.81acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
ENSAMXT00000038299.15.129e-723.97acid-sensing ion channel 1 [Source:NCBI gene;Acc:1... [more]
ENSAMXT00000047165.19.776e-723.97acid-sensing ion channel 1 [Source:NCBI gene;Acc:1... [more]
asic1c1.409e-623.85acid-sensing ion channel 1C-like [Source:NCBI gene... [more]
asic4a5.138e-630.10acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ASIC53.023e-638.60acid sensing ion channel subunit family member 5 [... [more]
ASIC53.427e-638.60acid sensing ion channel subunit family member 5 [... [more]
asic1a7.107e-625.00acid-sensing (proton-gated) ion channel 1a [Source... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO394463.557e-821.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO421371.617e-742.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361912.698e-728.97Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSORLT00000031246.12.792e-624.38acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
asic4a3.499e-632.47acid sensing ion channel subunit family member 4 [... [more]
ENSORLT00000008662.24.233e-623.55acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
ENSORLT00000031708.14.690e-624.38acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
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BLAST of Degenerin unc-8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016391.10.000e+087.40SMESG000016391.1[more]
SMESG000017678.10.000e+077.44SMESG000017678.1[more]
SMESG000069546.10.000e+077.35SMESG000069546.1[more]
SMESG000017668.10.000e+070.50SMESG000017668.1[more]
SMESG000017657.10.000e+055.51SMESG000017657.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30000044 ID=SMED30000044|Name=Degenerin unc-8|organism=Schmidtea mediterranea sexual|type=transcript|length=1693bp
AATTTATTATCGCATGCAATAATGAGATAAATCATTTAACCGAAATATGA
TTGAAATATTACAAAGCAGCACAATTCATGGAGTCAGTCACATTCACGGT
GCAAAAAGCCGAATTACCAAGATGTTATGGATCATTCTTTTTATTTTAGG
TCTTATTGGAATATTTGTTAACATTGTTTTTGTGATAATGAGGTATTTTT
CCAATCCAGTTTTAATTAGTCGTAATTTGGATCACGAACCGTTCATTTGG
CCTGATATAACATTTTGTAAGCCAACTGCGCCGTATTATTTTGTAGAAAA
TTCACAACCTTACAATCATTGGACAGAAGTATTCAGGAGAACAAGAAGAA
TTGTAGAACGATTATCAAATGAAACAGAATTTTTTAAAATCATGAATGGC
AAAAGAAATACTGATTATGAATTAGAAGAGAGAACTATAGCTATGTCGAG
CGCGGATCCCTATAAATTGAAAATGGACAATTTCAGTTATCACATAATGT
TAATTGTTTTTAACAGAATCCGAACATACACTAATTATATTAGTGATAAT
GAATTCTTCGAAAACTTTCACGAAGATTTGAAGCCATTATTTACAACTCA
ACTCGTTCAAATCGGAAACAATATCCCATGTTTCACTTTCCATATTGATA
GATCTAAATTTATTAATCAAAACTCAATAAAGTCTGTGAATTTTAACCTG
AAATTTAACCTGGAAAGTTATTTTCTGTTTAACTCAAGCTATTTGCACCG
TTCGGTATTCCTCTATATTAGCAATAGAAACTCATTTCCCCGTAGAAACG
AAATATTGTTAGCACCCGGATTTAACAATATAATTTCCCTCTCGCAAAGT
CGGTACGAATTAAAAGGTGTTCAACGAAAGTGTCGAAATGAAAAATATGT
TGTCGAATTATATGATGCGCTTTTGAAATCAACCTCGACCTTTGAAGGTC
ATTATGATGATTGCAAGAGAGTGGAAAGCCAGAGATTGTTTGTTAGGAAT
TGCAATTGTTACAGTCCGTTTTTGCCGATTTACAAAAACAAAACTGGACA
GCCGAGAATTTGTTTAAATGGAACGTTTTATTCCGAAGAAGAAATTCTTC
AAAACGCCAAATGCATGGTTGATGTCTTTAGGAGATTTCAAAGTTATAAA
GCATTCATGAATATTTTACATTCCAATTGTGAACATTACCGGTTTATTAA
GTGCAAAGAAGTCAAGTATGGCATTGAAAAAGAGAAGGAATTATTTGTCG
AGTTTTGGAGTGGATTGACAAATCAAAGACGCCAGAGACTAATAAAAAAA
TATTCTCGCCATCTCACTGAAAAATTCGATAATAAAAAGTATTTTGAGAG
AATGCGCGATAACTTTATAGGAATCGCAATAAAACGGGAAACTCAAAAAG
GGGATTTATATAAAGAAGAATATGAGTATCCCTTTTCGGAATTACTGTCT
GACATTGGAGGATTGATGGGACTGTGGTTAGGAATGAGTGTCGTTGGTTT
GTTTGAAATCTTTGAATTCATTTATTTATATTTAGTGAATTTATGTGGTC
GAACAAGAAAACAACAGCCAATTCTGGAAAAGTGTGAAATAAATCCTGCT
TCCCCATTATGACATGTGAATGTTTTGCAGAATTTATATTCTTTATTTTA
ATTTATTTGAAGTATAACGAAACGTTATTCCATTTGTTTTACG
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protein sequence of SMED30000044-orf-1

>SMED30000044-orf-1 ID=SMED30000044-orf-1|Name=SMED30000044-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=522bp
MIEILQSSTIHGVSHIHGAKSRITKMLWIILFILGLIGIFVNIVFVIMRY
FSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTR
RIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMDNFSYHI
MLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTTQLVQIGNNIPCFTFHI
DRSKFINQNSIKSVNFNLKFNLESYFLFNSSYLHRSVFLYISNRNSFPRR
NEILLAPGFNNIISLSQSRYELKGVQRKCRNEKYVVELYDALLKSTSTFE
GHYDDCKRVESQRLFVRNCNCYSPFLPIYKNKTGQPRICLNGTFYSEEEI
LQNAKCMVDVFRRFQSYKAFMNILHSNCEHYRFIKCKEVKYGIEKEKELF
VEFWSGLTNQRRQRLIKKYSRHLTEKFDNKKYFERMRDNFIGIAIKRETQ
KGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFEFIYLYLVNLC
GRTRKQQPILEKCEINPASPL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 473..489
score: 49.88
coord: 25..42
score: 18.67
coord: 314..331
score: 30.44
coord: 459..473
score: 36.53
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 6..493
e-value: 9.1E-45
score: 153.4
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 7..518
NoneNo IPR availableGENE3DG3DSA:1.10.3590.10coord: 78..238
e-value: 2.9E-26
score: 94.3
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 274..388
e-value: 2.9E-26
score: 94.3
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 55..461
e-value: 2.9E-26
score: 94.3
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 25..491
e-value: 2.9E-26
score: 94.3
NoneNo IPR availableTMHMMTMhelixcoord: 476..498
NoneNo IPR availableTMHMMTMhelixcoord: 26..48