Transforming growth factor-beta-induced protein

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSN---------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASS-NFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP    +NE     P     S          + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S    +     +  YT+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS     +M  ++     K+   ++D +A NGV H I++ LIP SA +  ++      +++ + F+       + G +       +  +L P++  F
Sbjct:   43 QHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAP----SNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQ--YTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGL-SVETLEGTTLEVGCS----GDMLTIN----GKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSE-------RLTLLAPLNSVF 420          

Query:  714 HVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAI----KNKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIP 1346
            H++K +  +  L + Q L      +KL+V  Y    +CI+   +   +   + G +  + + L P  GT      ++D LK D   S     I S+   E  N      YTV A  NE +RA+    +++  G   EL  I++ H+  ++  S  +   VR + +  G+++  E S +NN        +  +K      D MA NGV H+I   L P
Sbjct:  438 HIIKDQLASKYLYHGQTL-ETLGGKKLRVFVYR-NSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGT------VMDVLKGDNRFSMLVAAIQSAGLTETLNREG--VYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVR-LKSLQGDKL--EVSLKNNV-------VSVNKEPVAEPDIMATNGVVHVITNVLQP 634          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSL--------FPGSSRFAVMMKSPEMMSETPNQ-DFTIFAP-DQVNNNELSKIYPTSGQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-----ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWG 2066
            YD  ++++R    D QG   CA  + L      +S+C  +  K  CG+     Y+CC G+ ++                      K CP VL +          G++       + ++  E   +  FT FAP ++  +N  S I    G  SN      + +  H++  R    DL+N   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D ++++ + SSF      +DI  +L R+         +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS ++        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    ++P  +Y +L P++ +F D      Q      R LK       + + HI++    L +L +  + E  G K   R  ++     +++             ++  S + R+G+++    I    EK + + LK+     T  S ++ AD+ +L  +P    +LF+ T ++  K +T+ + + +I   D  AL+N +L H  P    G
Sbjct:   25 YDKILAHSRIRGRD-QGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRM-------------------EGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIR--RGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFIEAEDDLSSFRAAAITSDILEALGRDGH-------FTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAV-FETLEGNTIEIGCDGDS---------ITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASALRPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLNELYNGQILETIGGK-QLRVFVYRTAVCIEN-----------SCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQP-GDWTLFVPT-NDAFKGMTSEEKEILI--RDKNALQNIILYHLTPGVFIG 574          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSL--------FPGSSRFAVMMKSPEMMSETPNQ-DFTIFAP-DQVNNNELSKIYPTSGQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-----ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWG 2066
            YD  ++++R    D QG   CA  + L      +S+C  +  K  CG+     Y+CC G+ ++                      K CP VL +          G++       + ++  E   +  FT FAP ++  +N  S I    G  SN      + +  H++  R    DL+N   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D ++++ + SSF      +DI  +L R+         +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS ++        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    ++P  +Y +L P++ +F D      Q      R LK       + + HI++    L +L +  + E  G K   R  ++     +++             ++  S + R+G+++    I    EK + + LK+     T  S ++ AD+ +L  +P    +LF+ T ++  K +T+ + + +I   D  AL+N +L H  P    G
Sbjct:   25 YDKILAHSRIRGRD-QGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRM-------------------EGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIR--RGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFIEAEDDLSSFRAAAITSDILEALGRDGH-------FTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAV-FETLEGNTIEIGCDGDS---------ITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASALRPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLNELYNGQILETIGGK-QLRVFVYRTAVCIEN-----------SCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQP-GDWTLFVPT-NDAFKGMTSEEKEILI--RDKNALQNIILYHLTPGVFIG 574          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSL--------FPGSSRFAVMMKSPEMMSETPNQ-DFTIFAP-DQVNNNELSKIYPTSGQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-----ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWG 2066
            YD  ++++R    D QG   CA  + L      +S+C  +  K  CG+     Y+CC G+ ++                      K CP VL +          G++       + ++  E   +  FT FAP ++  +N  S I    G  SN      + +  H++  R    DL+N   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D ++++ + SSF      +DI  +L R+         +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS ++        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    ++P  +Y +L P++ +F D      Q      R LK       + + HI++    L +L +  + E  G K   R  ++     +++             ++  S + R+G+++    I    EK + + LK+     T  S ++ AD+ +L  +P    +LF+ T ++  K +T+ + + +I   D  AL+N +L H  P    G
Sbjct:   25 YDKILAHSRIRGRD-QGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRM-------------------EGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIR--RGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFIEAEDDLSSFRAAAITSDILEALGRDGH-------FTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAV-FETLEGNTIEIGCDGDS---------ITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASALRPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLNELYNGQILETIGGK-QLRVFVYRTAVCIEN-----------SCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQP-GDWTLFVPT-NDAFKGMTSEEKEILI--RDKNALQNIILYHLTPGVFIG 574          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSL--------FPGSSRFAVMMKSPEMMSETPNQ-DFTIFAP-DQVNNNELSKIYPTSGQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-----ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWG 2066
            YD  ++++R    D QG   CA  + L      +S+C  +  K  CG+     Y+CC G+ ++                      K CP VL +          G++       + ++  E   +  FT FAP ++  +N  S I    G  SN      + +  H++  R    DL+N   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D ++++ + SSF      +DI  +L R+         +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS ++        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    ++P  +Y +L P++ +F D      Q      R LK       + + HI++    L +L +  + E  G K   R  ++     +++             ++  S + R+G+++    I    EK + + LK+     T  S ++ AD+ +L  +P    +LF+ T ++  K +T+ + + +I   D  AL+N +L H  P    G
Sbjct:   25 YDKILAHSRIRGRD-QGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRM-------------------EGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIR--RGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFIEAEDDLSSFRAAAITSDILEALGRDGH-------FTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAV-FETLEGNTIEIGCDGDS---------ITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASALRPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLNELYNGQILETIGGK-QLRVFVYRTAVCIEN-----------SCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQP-GDWTLFVPT-NDAFKGMTSEEKEILI--RDKNALQNIILYHLTPGVFIG 574          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDPFAFKR-CGKTLEFGYDCCVGFQKL----GPPSFE--TNPYG--NQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSET-PNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIKNKYF------GTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFV-SQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLH-TVPLYLWGG 2069
            YD  VS++R    +E G   CA  ++      Y S+C  +  K  CGK     Y+CC G+ KL    G P+     + YG  + V AKT  Q+     +     G   + +   S +   E  P     + +   + N EL            + + YH+V  RF   DL+N+  L S++  Q L +  YS GV+ ++C  +   N    NGV+H I + +   S T      + D ++++ + SS +  + S+ LQ +L        YT+ A  NE +  I            T ++ +++ H+++ + CS A+        T  G  I + C  E+         L  +  K V  +D + +NGV H+I++ L+P SA    +++   +   S+            G    ++P  +Y +L P++ +F       +      R LK       +   HIV+    L  L +  + E  G K   R  ++     +++             +   S +  +G+L+ +S +  +PE  I ++L +    K   S ++ A +  L  K     +LF A +D     LT  K D  +   D   L+  LL H +  +++ GG
Sbjct:   25 YDKIVSHSRIRAKNE-GPNVCALQQVMGTKKKYFSTCRNWYKKSICGKKAIVLYECCPGYMKLEGKRGCPAVAPIDSVYGTLDLVKAKTTQQYADQSKLREEIAGEGSYTIFAPSDDAWEELDPASKAAVIS---LGNTELY-----------NALHYHMVSKRFLTKDLKNDMTLESMFNKQGLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVISVVSQT------IKDVIETNDDLSSLSGVVVSADLQDQLGEPG---HYTLFAPTNEAFDKINADALERLMSDQTVIQALLKYHLLNSVQCSEAIMAG-SIYGTLEGSNIEIGCDGES---------LTVNGIKMVLKKDIVTSNGVIHLIDQVLMPDSAKQVMELVGKSQSVFSDMVSE-------LGLSAALQPETEYTVLAPLNGAFS-----DEVMSMDQRLLK------IILENHIVKLKVSLRDLYNGQLLETLGGKM-LRVFIYRTAVCIEN-----------ACMVRGSREGSNGALHLMSSLIQMPETTIYELLLKDGRFKIFLSLMESAGLTDL-LKQDGSYTLF-APIDAAFGSLT--KDDLALLKSDINVLRTILLYHFSNGIFINGG 576          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDPFAFKR-CGKTLEFGYDCCVGFQKL----GPPSFE--TNPYG--NQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSET-PNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIKNKYF------GTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFV-SQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLH-TVPLYLWGG 2069
            YD  VS++R    +E G   CA  ++      Y S+C  +  K  CGK     Y+CC G+ KL    G P+     + YG  + V AKT  Q+     +     G   + +   S +   E  P     + +   + N EL            + + YH+V  RF   DL+N+  L S++  Q L +  YS GV+ ++C  +   N    NGV+H I + +      S     + D ++++ + SS +  + S+ LQ +L        YT+ A  NE +  I            T ++ +++ H+++ + CS A+        T  G  I + C  E+         L  +  K V  +D + +NGV H+I++ L+P SA    +++   +   S+            G    ++P  +Y +L P++ +F       +      R LK       +   HIV+    L  L +  + E  G K   R  ++     +++             +   S +  +G+L+ +S +  +PE  I ++L +    K   S ++ A +  L  K     +LF A +D     LT  K D  +   D   L+  LL H +  +++ GG
Sbjct:   25 YDKIVSHSRIRAKNE-GPNVCALQQVMGTKKKYFSTCRNWYKKSICGKKAIVLYECCPGYMKLEGKRGCPAVAPIDSVYGTLDLVKAKTTQQYADQSKLREEIAGEGSYTIFAPSDDAWEELDPASKAAVIS---LGNTELY-----------NALHYHMVSKRFLTKDLKNDMTLESMFNKQGLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVI------SVVSQTIKDVIETNDDLSSLSGVVVSADLQDQLGEPG---HYTLFAPTNEAFDKINADALERLMSDQTVIQALLKYHLLNSVQCSEAIMAG-SIYGTLEGSNIEIGCDGES---------LTVNGIKMVLKKDIVTSNGVIHLIDQVLMPDSAKQVMELVGKSQSVFSDMVSE-------LGLSAALQPETEYTVLAPLNGAFS-----DEVMSMDQRLLK------IILENHIVKLKVSLRDLYNGQLLETLGGKM-LRVFIYRTAVCIEN-----------ACMVRGSREGSNGALHLMSSLIQMPETTIYELLLKDGRFKIFLSLMESAGLTDL-LKQDGSYTLF-APIDAAFGSLT--KDDLALLKSDINVLRTILLYHFSNGIFINGG 576          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSR--FAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTS---GQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQ-DNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKD---KEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDI 2075
            MK L L       +    +A++   Y   + ++R      QG   CA  K+      Y ++C   +  K CGK     Y+CC G++K+          G + C   +P   +    LS+   ++   ++   K  E + E P   FT FAP    +NE     PT       SN      + + YH++  R  + DL++     S+YQ+  + +  YS G++ ++C  L K +    NG++H + + +   +  + D N+++D         +      + L   L+N  S   YT+ A  NE +  I      +  G    L+ ++  H++  L+CS ++      + T  G  + V C  E         DL  +    V+Q D +  NGV H I + LIP SA +  ++        S    A K F+     D L+   +   +L P++ +F   K ++   P+  + L++   KE     + YH      ELE L  L      ++ N    L   +  +   D +  Y                 +++ +  I   P+  ++D+LK      T    +QKA +   E   ++    F A  +     L +  ++K++   D K L N L  H    +L  G +
Sbjct:    1 MKRLTLFALAITLIATVFAAKSP--YQAVLQHSRI-RGRTQGPNVCAMQKIPGSDKKYFTNCKQWYRRKICGKPTVISYECCPGYEKV---------IGEKGCPAALP-LVNIYKTLSVVEATTTKMYSERAKLQEEI-EGPGS-FTFFAP----SNEAWAALPTEILDALVSNVNIELLNALHYHMINKRLTSEDLKHGSSFSSMYQDFDVHIHHYSNGIVTVNCARLVKTDQHATNGIVHVVDRVI---TAITNDVNSIIDTDDDLDTLRTAV--AAAGLTTLLENQGS---YTIFAPTNEAFEKIPPDTLTRILGDPVALKDLLNFHILKNLHCSESIVAGT-PLETLQGTMLEVGCDGE---------DLTINGKAVVTQKDKLGTNGVVHYINELLIPDSAKTLLEL-----AEGSVVTTAAKLFKDAGLNDHLVG-SESVTLLAPLNEAFK-DKSFA-MTPDMKKLLRNHILKEKFSSKSLYH----GQELETLGGLKLRVFVFRNN----LCIENACIAAHDKNGRY----------------ANMFLVDSILTPPQGTVMDVLKADNRFSTLVGAIQKAGLT--ELLNKKGTYTFFAPTNAAFSALPSADLNKLM--RDPKELANILKYHIGDEFLVSGAV 576          

Query:  219 IFVF-VFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYG--NQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENW---------RAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFD 1508
            +FV   F Q  SSA     YD  V+++R     +QG   CA  ++      Y S+C + +    CGKT    Y+CC G+ +L    G P+     N +G    V AKT   +     +     G+  +             P+ D       +V N  +S +         + + YH+V  R    DL+N     S+Y +  L +  YS GV+ ++C  +   N    NGV+H I + +     T  D   + D L +    S+ A D  S L  +L        +T+ A  N  +         R +K+K     L+ ++  H+++ + CS A+        T  G  I + C     T N  +M             + +D +A NGV H+I++ L+P SA    +++   +   S+            G    M+P  +Y +L P++ +F+
Sbjct:   11 LFVLSAFDQADSSA-----YDKIVAHSRI-RAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFF---------APSNDAWDLLEAEVRNALVSNVNIEL----YNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLST---LSTVATD--SGLIDKLGEPG---HFTLFAPTNAAFDKLGREVLDRLMKDK---KSLQALLNYHLLNSVQCSEAIMAGTSH-ETLEGSNIEIGCDGDSLTVNGIKM------------VLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTE-------LGLSAAMRPQAEYTLLAPVNAAFN 414          

Query:  219 IFVF-VFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYG--NQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENW---------RAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFD 1508
            +FV   F Q  SSA     YD  V+++R     +QG   CA  ++      Y S+C + +    CGKT    Y+CC G+ +L    G P+     N +G    V AKT   +     +     G+  +             P+ D       +V N  +S +         + + YH+V  R    DL+N     S+Y +  L +  YS GV+ ++C  +   N    NGV+H I + +     T  D   + D L +    S+ A D  S L  +L        +T+ A  N  +         R +K+K     L+ ++  H+++ + CS A+        T  G  I + C     T N  +M             + +D +A NGV H+I++ L+P SA    +++   +   S+            G    M+P  +Y +L P++ +F+
Sbjct:   11 LFVLSAFDQADSSA-----YDKIVAHSRI-RAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFF---------APSNDAWDLLEAEVRNALVSNVNIEL----YNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLST---LSTVATD--SGLIDKLGEPG---HFTLFAPTNAAFDKLGREVLDRLMKDK---KSLQALLNYHLLNSVQCSEAIMAGTSH-ETLEGSNIEIGCDGDSLTVNGIKM------------VLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTE-------LGLSAAMRPQAEYTLLAPVNAAFN 414          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFAN-DIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTE--LEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNT 2096
            MK L L +F    L     A+ N  YD  ++++R     +QG   CA  + L      +S+C + +    CGK     Y+CC G+ K+    G P+     N YG    V A +   +    ++     G   +             P+ D        V ++ LS +         + + YH++  R    DL+N   + S++ NQ+L +  Y+ GV+ ++C  +   N    NGV+H I + +V   G     N + D ++S+ E +SF    + + +  EL     K  YT+ A  N+ +    R +  +  G +  ++ +V  H+++ + CS A+      + T  G  + + C  ++         L  + +K V+ +D +  NGV H+I++ LIP SA    ++  + +   ++            G     +P  +Y +L PI+ +F       +      R LK       + + H+++    L  L    +  +  +T    LL    Y       + +    S ++   S + R+G+++  S I    EK   D+L          + ++ A +  L  +P    + F+ T ++  K L+  +++  I   D  AL+N LL H  P    GG    F+P  
Sbjct:    1 MKGLFLCVFATFLLSAIDHAEGNAYYDKILTHSRI-RARQQGPNVCALQQVLGTKKKYFSTCKNWYQGAICGKKATILYECCPGYMKINGESGCPAVAPIDNVYGTLGIVGATSTQDYSDRSELRKEIEGVGSYTFF---------APSNDAWQLLDSDVRDSLLSNVNIEL----LNALHYHMINKRMLTKDLKNGLSVTSMFNNQELVINHYTNGVVTVNCARVIHGNQIATNGVVHVIDR-VVTAVG-----NTIEDFIESEDELTSFREAGVAAEVLAELG---KKGQYTLFAPTNDAFEKLPRGVLERIMGDKQAVKALVNYHILNSVQCSEAIMGG-SLLETLEGSSLQIGCDGDS---------LTVNGNKMVNRKDIVTTNGVIHLIDQVLIPDSAKQVLELAGSEQTTFTDLMAQ-------MGLAASFRPDAEYTLLAPINNAFS-----DETLKMDQRILK------LILQNHVLKTKVALNGL----YNGQTLETLGGKLLRVFVY------RTAVCIENSCMLR-GSKEGRNGAIHIFSEIIKPAEKSFYDLLSLDKRFSIFLNLIEFAGLKDLLLQP-GAWTWFIPT-NDAFKGLSNEEME--ILKRDKVALQNILLYHLAPEVFIGGG---FEPGV 582          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFAN-DIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTE--LEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPN 2093
            MK L L +F    L     A+ N  YD  ++++R     +QG   CA  + L      +S+C   +    CGK     Y+CC G+ K+    G P+     N YG    V A +   +    ++     G   +             P+ D        V ++ LS +         + + YH++  R    DL+N   + S++ NQ+L +  Y+ GV+ ++C  +   N    NGV+H I + +V   G     N + D ++S+ E +SF    + + +  EL     K  YT+ A  N+ +    R +  +  G +  ++ +V  H+++ + CS A+      + T  G  + + C  ++         L  + +K V+ +D +  NGV H+I++ LIP SA    ++  + +   ++            G     +P  +Y +L PI+ +F       +      R LK       + + H+++    L  L    +  +  +T    LL    Y       + +    S ++   S + R+G+++  S I    EK   D+L          + ++ A +  L  +P    + F+ T ++  K L+  +++  I   D  AL+N LL H  P    GG    F+P 
Sbjct:    2 MKGLFLCVFATFLLSAIDHAEGNAYYDKILTHSRI-RARQQGPNVCALQQVLGTKKKYFSTCKNWYQGAICGKKATILYECCPGYMKINGESGCPAVAPIDNVYGTLGIVGATSTQDYSDRSELRKEIEGVGSYTFF---------APSNDAWQLLDSDVRDSLLSNVNIEL----LNALHYHMINKRMLTKDLKNGLSVTSMFNNQELVINHYTNGVVTVNCARVIHGNQIATNGVVHVIDR-VVTAVG-----NTIEDFIESEDELTSFREAGVAAEVLAELGK---KGQYTLFAPTNDAFEKLPRGVLERIMGDKQAVKALVNYHILNSVQCSEAIMGG-SLLETLEGSSLQIGCDGDS---------LTVNGNKMVNRKDIVTTNGVIHLIDQVLIPDSAKQVLELAGSEQTTFTDLMAQ-------MGLAASFRPDAEYTLLAPINNAFS-----DETLKMDQRILK------LILQNHVLKTKVALNGL----YNGQTLETLGGKLLRVFVY------RTAVCIENSCMLR-GSKEGRNGAIHIFSEIIKPAEKSFYDLLSLDKRFSIFLNLIEFAGLKDLLLQP-GAWTWFIPT-NDAFKGLSNEEME--ILKRDKVALQNILLYHLAPEVFIGGG---FEPG 582          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFAN-DIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTE--LEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            MK L L +F    L     A+ N  YD  ++++R     +QG   CA  + L      +S+C   +    CGK     Y+CC G+ K+    G P+     N YG    V A +   +    ++     G   +             P+ D        V ++ LS +         + + YH++  R    DL+N   + S++ NQ+L +  Y+ GV+ ++C  +   N    NGV+H I + +V   G     N + D ++S+ E +SF    + + +  EL     K  YT+ A  N+ +    R +  +  G +  ++ +V  H+++ + CS A+      + T  G  + + C  ++         L  + +K V+ +D +  NGV H+I++ LIP SA    ++  + +   ++            G     +P  +Y +L PI+ +F
Sbjct:    2 MKGLFLCVFATFLLSAIDHAEGNAYYDKILTHSRI-RARQQGPNVCALQQVLGTKKKYFSTCKNWYQGAICGKKATILYECCPGYMKINGESGCPAVAPIDNVYGTLGIVGATSTQDYSDRSELRKEIEGVGSYTFF---------APSNDAWQLLDSDVRDSLLSNVNIEL----LNALHYHMINKRMLTKDLKNGLSVTSMFNNQELVINHYTNGVVTVNCARVIHGNQIATNGVVHVIDR-VVTAVG-----NTIEDFIESEDELTSFREAGVAAEVLAELGK---KGQYTLFAPTNDAFEKLPRGVLERIMGDKQAVKALVNYHILNSVQCSEAIMGG-SLLETLEGSSLQIGCDGDS---------LTVNGNKMVNRKDIVTTNGVIHLIDQVLIPDSAKQVLELAGSEQTTFTDLMAQ-------MGLAASFRPDAEYTLLAPINNAF 415          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFAN-DIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTE--LEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            MK L L +F    L     A+ N  YD  ++++R     +QG   CA  + L      +S+C   +    CGK     Y+CC G+ K+    G P+     N YG    V A +   +    ++     G   +             P+ D        V ++ LS +         + + YH++  R    DL+N   + S++ NQ+L +  Y+ GV+ ++C  +   N    NGV+H I + +V   G     N + D ++S+ E +SF    + + +  EL     K  YT+ A  N+ +    R +  +  G +  ++ +V  H+++ + CS A+      + T  G  + + C  ++         L  + +K V+ +D +  NGV H+I++ LIP SA    ++  + +   ++            G     +P  +Y +L PI+ +F
Sbjct:    2 MKGLFLCVFATFLLSAIDHAEGNAYYDKILTHSRI-RARQQGPNVCALQQVLGTKKKYFSTCKNWYQGAICGKKATILYECCPGYMKINGESGCPAVAPIDNVYGTLGIVGATSTQDYSDRSELRKEIEGVGSYTFF---------APSNDAWQLLDSDVRDSLLSNVNIEL----LNALHYHMINKRMLTKDLKNGLSVTSMFNNQELVINHYTNGVVTVNCARVIHGNQIATNGVVHVIDR-VVTAVG-----NTIEDFIESEDELTSFREAGVAAEVLAELGK---KGQYTLFAPTNDAFEKLPRGVLERIMGDKQAVKALVNYHILNSVQCSEAIMGG-SLLETLEGSSLQIGCDGDS---------LTVNGNKMVNRKDIVTTNGVIHLIDQVLIPDSAKQVLELAGSEQTTFTDLMAQ-------MGLAASFRPDAEYTLLAPINNAF 415          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFAN-DIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTE--LEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            MK L L +F    L     A+ N  YD  ++++R     +QG   CA  + L      +S+C   +    CGK     Y+CC G+ K+    G P+     N YG    V A +   +    ++     G   +             P+ D        V ++ LS +         + + YH++  R    DL+N   + S++ NQ+L +  Y+ GV+ ++C  +   N    NGV+H I + +V   G     N + D ++S+ E +SF    + + +  EL     K  YT+ A  N+ +    R +  +  G +  ++ +V  H+++ + CS A+      + T  G  + + C  ++         L  + +K V+ +D +  NGV H+I++ LIP SA    ++  + +   ++            G     +P  +Y +L PI+ +F
Sbjct:    2 MKGLFLCVFATFLLSAIDHAEGNAYYDKILTHSRI-RARQQGPNVCALQQVLGTKKKYFSTCKNWYQGAICGKKATILYECCPGYMKINGESGCPAVAPIDNVYGTLGIVGATSTQDYSDRSELRKEIEGVGSYTFF---------APSNDAWQLLDSDVRDSLLSNVNIEL----LNALHYHMINKRMLTKDLKNGLSVTSMFNNQELVINHYTNGVVTVNCARVIHGNQIATNGVVHVIDR-VVTAVG-----NTIEDFIESEDELTSFREAGVAAEVLAELGK---KGQYTLFAPTNDAFEKLPRGVLERIMGDKQAVKALVNYHILNSVQCSEAIMGG-SLLETLEGSSLQIGCDGDS---------LTVNGNKMVNRKDIVTTNGVIHLIDQVLIPDSAKQVLELAGSEQTTFTDLMAQ-------MGLAASFRPDAEYTLLAPINNAF 415          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNEL-SKIYPTSGQGSN----DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIK--GCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP     + L +++  +     N    + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S L   L+       +T+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS +              K+   ++D +A NGV H I++ LIP SA +  ++      +++         + +K  G D  +   ++   L P++  F
Sbjct:   43 QHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQ---FTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGM-SMETLGGTTLEVGCSGDKLT--------INGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTA--------IDILKQAGLDTHLSGKEQLTFLAPLNSVF 420          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNEL-SKIYPTSGQGSN----DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIK--GCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP     + L +++  +     N    + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S L   L+       +T+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS +              K+   ++D +A NGV H I++ LIP SA +  ++      +++         + +K  G D  +   ++   L P++  F
Sbjct:   43 QHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQ---FTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGM-SMETLGGTTLEVGCSGDKLT--------INGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTA--------IDILKQAGLDTHLSGKEQLTFLAPLNSVF 420          

Query:  255 AQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVP-LYLWGGDIGYFKPNT 2096
            A  N  YD  ++++R    D QG   CA  + L      +SSC   +    CGK     Y+CC G+ ++    G P+     + YG    V A T   +     +     G   +     S E   E  + D      + VN   L+ ++             H+V  R    DL++   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D L+++ + SSF A  I S L   L++      +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS A+        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    +KP  +Y +L P++ +F D      Q      R LK       + + HI++    L  L +  + E  G K        ++  F+     + +    S +V   S + R+G+++    I    EK + D L++        S ++ AD+  L  +P    +LF  T ++  K +T+ + + +I   D  AL+N +L H  P +Y+  G    F+P  
Sbjct:   21 ANANSYYDKVLAHSRIRGRD-QGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAW-ENLDSDIRRGLENNVNVELLNALHS------------HMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFLEAEDDLSSFRAAAITSDL---LESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAV-FETMEGNTIEIGCEGDS---------ISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLSDLYNGQILETIGGK--------QLRVFVY---RTAICIENSCMVR-GSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQP-GDWTLFAPT-NDAFKGMTSEERELLIG--DKNALQNIILYHLTPGVYIGKG----FEPGV 583          

Query:  609 PNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFY-HVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNK----YFGTE--LEKIVRNHVISKLYCSAALYKSVREI-TTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDIL 1376
            P+ ++T+ AP    NN  S    +  Q     +   H++K +   SDL N Q ++     ++L+V  Y    ICI+   + + + + +NG IH  R+ + P         +L D L+ D   S F + + ++  ++L  T+   W T+ A  N+ ++ + ++      G +  L+ I+  H+   +Y        V  I  T+ G +I ++   E       V++L   KSK    D M  NGV H+++K L P      ND L
Sbjct:  401 PDGEYTLLAP---VNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQ-ILETIGGKQLRVFVYRT-AICIENSCMVRGSKQGRNGAIHIFREIIQPA------EKSLHDKLRQDKRFSIFLSLLEAADLKDLL-TQPGDW-TLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNET----LLVNEL---KSK--ESDIMTTNGVIHVVDKLLYPADIPVGNDQL 642          

Query:  255 AQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVP-LYLWGGDIGYFKPN 2093
            A  N  YD  ++++R    D QG   CA  + L      +SSC   +    CGK     Y+CC G+ ++    G P+     + YG    V A T   +     +     G   +     S E   E  + D      + VN   L+ ++             H+V  R    DL++   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D L+++ + SSF A  I S L   L++      +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS A+        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    +KP  +Y +L P++ +F D      Q      R LK       + + HI++    L  L +  + E  G K        ++  F+     + +    S +V   S + R+G+++    I    EK + D L++        S ++ AD+  L  +P    +LF  T ++  K +T+ + + +I   D  AL+N +L H  P +Y+  G    F+P 
Sbjct:   21 ANANSYYDKVLAHSRIRGRD-QGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAW-ENLDSDIRRGLENNVNVELLNALHS------------HMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFLEAEDDLSSFRAAAITSDL---LESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAV-FETMEGNTIEIGCEGDS---------ISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLSDLYNGQILETIGGK--------QLRVFVY---RTAICIENSCMVR-GSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQP-GDWTLFAPT-NDAFKGMTSEERELLIG--DKNALQNIILYHLTPGVYIGKG----FEPG 582          

Query:  609 PNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFY-HVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNK----YFGTE--LEKIVRNHVISKLYCSAALYKSVREI-TTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDIL 1376
            P+ ++T+ AP    NN  S    +  Q     +   H++K +   SDL N Q ++     ++L+V  Y    ICI+   + + + + +NG IH  R+ + P         +L D L+ D   S F + + ++  ++L  T+   W T+ A  N+ ++ + ++      G +  L+ I+  H+   +Y        V  I  T+ G +I ++   E       V++L   KSK    D M  NGV H+++K L P      ND L
Sbjct:  401 PDGEYTLLAP---VNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQ-ILETIGGKQLRVFVYRTA-ICIENSCMVRGSKQGRNGAIHIFREIIQPA------EKSLHDKLRQDKRFSIFLSLLEAADLKDLL-TQPGDW-TLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNET----LLVNEL---KSK--ESDIMTTNGVIHVVDKLLYPADIPVGNDQL 642          

Query:  255 AQNNVIYDTQVSNARYAEPDEQGYRYCAHWK-LADGTTLYSSCDP-FAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF-ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFGTEL--EKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVS-QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF-DWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKL-SSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVP-LYLWGGDIGYFKPN 2093
            A  N  YD  ++++R    D QG   CA  + L      +SSC   +    CGK     Y+CC G+ ++    G P+     + YG    V A T   +     +     G   +     S E   E  + D      + VN   L+ ++             H+V  R    DL++   + S+Y N  L +  Y  GV+ ++C  +   N    NGV+H I + L  + GTS       D L+++ + SSF A  I S L   L++      +T+ A  NE +    R +  +  G ++  E +++ H+++ L CS A+        T  G  I + C  ++         +  +  K V+ +D +  NGV H+I++ LIP SA    ++    +   ++            G    +KP  +Y +L P++ +F D      Q      R LK       + + HI++    L  L +  + E  G K        ++  F+     + +    S +V   S + R+G+++    I    EK + D L++        S ++ AD+  L  +P    +LF  T ++  K +T+ + + +I   D  AL+N +L H  P +Y+  G    F+P 
Sbjct:   21 ANANSYYDKVLAHSRIRGRD-QGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAW-ENLDSDIRRGLENNVNVELLNALHS------------HMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLT-QIGTSIQ-----DFLEAEDDLSSFRAAAITSDL---LESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAV-FETMEGNTIEIGCEGDS---------ISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ-------LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQ------RLLK------LILQNHILKVKVGLSDLYNGQILETIGGK--------QLRVFVY---RTAICIENSCMVR-GSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQP-GDWTLFAPT-NDAFKGMTSEERELLIG--DKNALQNIILYHLTPGVYIGKG----FEPG 582          

Query:  609 PNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFY-HVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNK----YFGTE--LEKIVRNHVISKLYCSAALYKSVREI-TTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDIL 1376
            P+ ++T+ AP    NN  S    +  Q     +   H++K +   SDL N Q ++     ++L+V  Y    ICI+   + + + + +NG IH  R+ + P         +L D L+ D   S F + + ++  ++L  T+   W T+ A  N+ ++ + ++      G +  L+ I+  H+   +Y        V  I  T+ G +I ++   E       V++L   KSK    D M  NGV H+++K L P      ND L
Sbjct:  401 PDGEYTLLAP---VNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQ-ILETIGGKQLRVFVYRTA-ICIENSCMVRGSKQGRNGAIHIFREIIQPA------EKSLHDKLRQDKRFSIFLSLLEAADLKDLL-TQPGDW-TLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNET----LLVNEL---KSK--ESDIMTTNGVIHVVDKLLYPADIPVGNDQL 642          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSN---------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  KL      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP VL L        V+  +             PEM  E P   FTIFAP    +NE     P     S          + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S    L     +  YT+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS     +M  ++     K    ++D +A NGV H I++ LIP SA +  ++      A S+   A   F    G    +   ++  +L P++  F
Sbjct:   43 QHGPNVCAVQKLIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAVLPLSNLYETLGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAP----SNEAWASLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMALTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STVTNNIQQIIEIEDTFETLRAAVAASGLNTLLEGDGQ--YTLLAPSNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGL-SLETLEGTTLEVGCS----GDMLTIN----GKPIISNKDVLATNGVIHFIDELLIPDSAKTLFEL-----AAESDVSTAVDLFRQ-AGLGSHLSGNERLTLLAPMNSVF 420          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNEL-SKIYPTSGQGSN----DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASS-NFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  KL      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP     + L +++  +     N    + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S    L     +  YT+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS     +M  ++     K    ++D +A NGV H I++ LIP SA +  ++  +   +++ + F+       + G        ++  +L P++  F
Sbjct:   43 QHGPNVCAVQKLIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETLGVVGATTTQLYTDRTEKLRPEM--EGPG-SFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMALTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STVTNNIQQIIEIEDTFETLRAAVAASGLNTLLEGDGQ--YTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGL-SLETLEGTTLEVGCS----GDMLTIN----GKPIISNKDVLATNGVIHFIDELLIPDSAKTLFELAADSDVSTAIDLFRQAGLSSHLSG-------NERLTLLAPMNSVF 420          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSN---------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFD 1508
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  +SCP  L L        V+  +             PEM  E P + FTIFAP    +NE     P     S          + + YH+V  R    +L++   L S+YQN K ++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S    L  +  +  +T+LA  NE    I     N+  G    L  ++ NH++    C+ A+   +  + T     + V CS     +M  ++     K+   ++D +A NGV H I++ LIP SA + +++      A S+   A   F    G    +   ++  +L P++  F+
Sbjct:   43 QHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGERSCPAALPLANLYETLGVVGSTTTQLYTDRTEKLRPEM--EGPGR-FTIFAP----SNEAWASLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMALTSMYQNSKFQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STVTNNIQQIIEIEDTFETLRAAVAASGLNTLLESDGQ--FTLLAPTNEAKEKIPTETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGL-SMETLEATTLEVGCS----GDMLTIN----GKAIISNKDVLATNGVIHFIDELLIPDSAKTLSEL-----AAGSDVSTAIDLFGQ-AGLGTHLSGNERLTLLAPLNSVFE 421          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSN---------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASS-NFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP    +NE     P     S          + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S    +     +  YT+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS     +M  ++     K+   ++D +A NGV H I++ LIP SA +  ++      +++ + F+       + G +       +  +L P++  F
Sbjct:   43 QHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAP----SNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQ--YTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGL-SVETLEGTTLEVGCS----GDMLTIN----GKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSE-------RLTLLAPLNSVF 420          

Query:  315 EQGYRYCAHWKLADGTTLY-SSCDP-FAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS-------------PEMMSETPNQDFTIFAPDQVNNNEL-SKIYPTSGQGSN----DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIK--GCDLLMKPGKKYAILMPIDRSF 1505
            + G   CA  K+      Y ++C   +  K CGK+    Y+CC G++K                   +P  K CP  L L        V+  +             PEM  E P   FTIFAP     + L +++  +     N    + + YH+V  R    +L++   L S+YQN  +++  Y  G++ ++C  L KA+    NGV+H I K +      S   NN+   ++ +    +    + +S L   L+       +T+LA  NE +  I     N+  G    L  ++ NH++    C+ A+   +  + T  G  + V CS +              K+   ++D +A NGV H I++ LIP SA +  ++      +++         + +K  G D  +   ++   L P++  F
Sbjct:   43 QHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEK-------------------VPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEM--EGPG-SFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVI------STITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQ---FTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGM-SMETLGGTTLEVGCSGDKLT--------INGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTA--------IDILKQAGLDTHLSGKEQLTFLAPLNSVF 420          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQK----LGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSG-TSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTE--NNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNR-DLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKII-----AGYDG--KALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKI 2483
            MK    +    VF+ N   A   V++  Q +   +A PD+ GY YCA WKL DGT LYS CDP+  +RCG+ LEF Y+CC GF+K    LG PS       +  C K IPQ++ C  VL    G SR A  ++    + +   Q FTIFAP   + ++L   Y     G++  V YHVVKGR YA  L+N  +L SVYQNQKL +++  +G + ++C EL++A++EC++G+IH IR+PL PR G  + D+ +L+  L+S+ ET  FAND+P  LQREL+ T     YTV A    +WR +K       +++I  +HV     CS+ LYKS + +T  +G+ ++VECS +  N  E+  + D+CG+   F   D  A NGV H+++ P+ P S ++  D ++ P+CA +N    +KF   IK CDL M    +YA++ P + +FDWWK Y QF+ EY R+  DKEYRCRVARYHI++ +  L+ +        G++TNN+ D L+E  YF KD+  S L FH+S V +F S   +  S+++ SRINVIPEK + +++   P L  +++ ++ AD +    KP  P +LFL T ++G  D  +  + K +     A + G  +  + Y LL+ VPLYLWGGDIGYF  N+V RF S +G++LIFWM+    MRIGYDGLP E+W +VVKFN HAKDGIVW+L R L CPP+LC   + + D D+Y  Y +AC   +LPG    KD K+ F  +P +IA  +P KC + KQ   + TK +
Sbjct:   20 MKPCTGVSLAAVFV-NILFAAEGVVFGDQSNPPAFAFPDDYGYHYCASWKLPDGTLLYSGCDPYTIERCGQKLEFSYNCCSGFEKSSIPLGGPS-------STPCGKMIPQFEDCSTVLESM-GFSRMADHVRKIPELKQKNGQPFTIFAPLPADGSDLESTY----AGNSAAVKYHVVKGRHYADSLKNGMQLESVYQNQKLDISRSPYGTVSVECTELSQADIECQSGLIHIIRRPLTPRLGLGNLDKTSLMSLLRSNSETQEFANDLPQDLQRELEMTDGSTMYTVTAPPARSWREMKQGKTPEAIQQIAASHVSKGKKCSSDLYKSSQSMTRVNGKNVNVECSVDKNNQQEVHKIKDVCGNTHAFTKTDQTAGNGVLHMLDSPVPPSSTLTLKDFIDRPECAKAN--NIDKFINDIKDCDLYMNDADQYAVIAPENSAFDWWKNYPQFKKEYERYQTDKEYRCRVARYHIIKHDGNLKNIEQFSGHTDGHRTNNKFDELYETTYFTKDKMGSKLNFHYSTVTNFDSIPLKGSSIFKTSRINVIPEKNVSEVVNSAPELSHAANIMKVADAENKITKPNNPKNLFLVTENDGWLDPRSKALGKNVLSPELAAFQGSPERAEKYTLLNHVPLYLWGGDIGYFDKNSVHRFPSSAGVDLIFWMNDKNEMRIGYDGLPTEEWPKVVKFNQHAKDGIVWVLDRVLKCPPQLC--PLQLEDTDIYTFYTAACITADLPG---EKDVKVGFANQPTEIAKRHPDKCLVIKQGEVRTTKDL 776          

Query:  168 NIETTSIESSMKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQK----LGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSG-TSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECST--ENNAEMRYVSDLCGSKSKFVSQ--DNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNR-DLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKII-----AGYDGKAL--KNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKC 2441
            N  T S       + L++  ++ L    S    + ++   S  +YA+PD+ GYR CA W LADGT +YS CDPF  KRCGK LEF Y CC GFQ     LG PS  +NP     C K IPQ+  CP V+    G  +FA  +K+   +++   Q +TIF P   +  +L +IY     G+   V YHVV+GR YA DLR   +L S+Y ++ +++++ ++G + ++C E+++A++ECK+G+IH IR+PL+PRSG  + ++N+++  L+S+PET  FA  +P  LQ++L       +YTV A  + +W +++ +Y   +LE I  +HV   L C++ + K  +  T   G+ + VECS    N  E+R ++D CG   +FV +  D MAANGV H+I  P+IP+S ++  D+++ P+CA   F   +KF   ++ CDL M    +YA++ P + +FDWW GY+QF+PEY RF  DKEYRC VARYHIV+ N  L  +        G+++NNR D L+E  YF K +  S L +H+SPV + +  K ++ S+Y+ SRINV+PEK I +IL+E  +   ++S  + A M++  FK + P +L+L T DEG  D  + ++ K +     A Y+G A   +N+  L+ VPLYLWGGDIGYF+ N+V RFMS +G+ELIFWMD    MRIGYD LPK +W +VV++NL  +DGI+W L   L CP KLC   + + D D Y  Y +AC   +L G  D K A   F+++P +IA  +PT+C
Sbjct:   45 NYSTHSSSDKKMGVALLVLAYICL----STVTAIRFEQNPSPPQYAKPDQYGYRMCASWLLADGTPIYSGCDPFKTKRCGKELEFDYRCCSGFQHSNEPLGGPS--SNP-----CGKLIPQFDDCPSVIEEL-GFRKFASYLKNYPELTQRNGQPYTIFVPLPEDGGDLDRIY----GGNTRTVSYHVVRGRHYADDLRTGVKLKSIYNDEDIEISRTTYGSVNVECTEISQADIECKSGLIHIIRRPLLPRSGLGNLNKNSVMSLLQSNPETLEFAKALPQELQQDLSRVEGGHFYTVTAPTSNSWSSLRGRYNREQLEDIAASHVSKGLKCTSNIIKGQQTFTDMQGQPMKVECSVNPSNRQEIRKITDACGDTHEFVDRQSDLMAANGVVHVIRSPVIPMSQLTLKDLMDRPECA--KFQNIDKFINVLRECDLYMDGASQYAVITPENSAFDWWSGYAQFRPEYQRFQVDKEYRCEVARYHIVKHNGNLANIQDFSGHTDGHRSNNRNDYLYETTYFTKGKMGSTLNWHYSPVNNLQPLKLKNTSIYKTSRINVMPEKNITNILEERKDFSHTNSITKIAGMEENVFKKKAPKNLYLVTTDEGWIDPRSRQLGKKLVSPELARYEGHATLAENFAKLNHVPLYLWGGDIGYFEKNSVHRFMSSAGVELIFWMDDKGTMRIGYDELPKSEWPKVVEYNLPGRDGIIWALDGFLRCPNKLCA--LQLEDKDTYTFYTAACLTSDLEGEVDVKRA---FSSKPTEIAKRHPTQC 796          

Query:  180 TSIESSMKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQK----LGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSND-PVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSG-TSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNA-EMRYVSDLCGSKSKFVS--QDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNR-DLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAG-----YDG--KALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKI 2483
            T +  S+    + I  ++F    + A    I   Q S  +Y++PD+ GYR C+ W+LADGT +YS CDPF   RCG+ L+F Y CC GFQ     LG  S       N  CAK IPQ+  CP V+    G  +FA  +++   +++   Q FTIF P   N  +L +IY     GSN   V YHV KGR+Y+  LR   EL S+Y ++K+K+T+ SFG I ++C E+++A++EC +G+IH IR PLVPRSG  S D+++++  L+++ ET  FAN +P  LQ +L N  S + YTV     ++W  ++++Y   +LE I  +HV   L C++ LYK  + IT+  G+  +VECS  +   E+R + D CG   +F++   D +A NGV H+I  P+IP S ++  D +  P+CA   +   +KF + ++ CDL M    +YA++ P + +FDWW+ Y QF+ EY RF  DKEYRCRVARYHIV+ N  L  ++       G++TNN+ D L+E  YF K +  S+L +H+SPV + K+   +  S+Y+ SRINVIPEK I +IL E  +   S S  Q ADM+   F  + P +L+L T D+G  D  + ++ K +       Y+   +  +N+  L+ +PLYLWGGDIGYF+ N+V RFMS  G+ELIFWMD+   MRIGYDGLP   W  VV+FNL A+DGI+W+L   L CPP LC   + + D D+Y  Y +AC   +L G  D K A   F+++PI+IA  +P KC I KQ      K I
Sbjct:   85 TPLSESLVMRAVTILFYLFGHFLAGA----IRFEQPSAPQYSDPDQHGYRMCSSWRLADGTPIYSGCDPFVVDRCGQELKFDYRCCSGFQHSHEYLGGDS-------NNPCAKLIPQFSDCPSVVEGL-GFKKFASYLRNFPELTQKNGQPFTIFVPLPENGGDLDRIY-----GSNHRAVGYHVAKGRYYSDSLRTGVELESIYNSEKIKITRTSFGSINVECTEVSQADIECGSGLIHIIRHPLVPRSGLGSLDKSSVMTLLRTNSETRDFANYLPQKLQADLANVASGVTYTVTVPSAQSWSNLRDRYSREQLEIIASSHVNVGLKCTSNLYKGEQSITSVMGQPRTVECSISSGGKEVRTIIDACGQAHEFIAGQSDQVATNGVVHLISSPVIPTSLLTLKDFIERPECA--KYQNIDKFMDVLRDCDLYMNDADQYAVIAPENSAFDWWRNYHQFRAEYERFQVDKEYRCRVARYHIVKHNGNLANITDFSGHTNGHRTNNKHDYLYETTYFTKHKMGSNLNWHYSPVNNLKTVPLKATSIYKTSRINVIPEKNITEILNERKDFSHSKSITQTADMETNVFSKKAPTNLYLVTNDDGWIDPRSKQMGKALVSPELSLYESVPELSENFAKLNHIPLYLWGGDIGYFEKNSVHRFMSTVGVELIFWMDEQGTMRIGYDGLPNSDWPRVVEFNLPARDGIIWVLDGFLKCPPNLC--SMQLEDTDVYTFYTAACITTDLEGEADVKKA---FSSQPIEIAKRHPDKCVIIKQGEVTTVKDI 845          

Query:  204 SLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQK----LGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSG-TSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECST--ENNAEMRYVSDLCGSKSKFVSQ--DNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRD-LLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKII-----AGYDGKAL--KNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKI 2483
             + L++  ++ L    S    + ++   S  +YA+PD+ GYR CA W LADGT +YS CDPF  KRCGK LEF Y CC GFQ     LG PS  +NP     C K IPQ+  CP V+    G  +FA  +K+   +++   Q +TIF P   +  +L +IY     G+   V YHV KGR YA DLR   +L S+Y ++ +++++ ++G       ++++A++ECK+G+IH IR+PLVPRSG  + ++N+++  L+S+PET  FAN +P  LQ++L       +YTV A  +++W +++ +Y   +LE I  +HV   L C++ + K  +  T   G+ + VECS    N  E+R ++D CG   +FV +  D MAANGV H+I  P+IP+S ++  D+++ P+CA   +   +KF + ++ CDL M    +YA++ P + +FDWW GY+QF+PEY RF  DKEYRC VARYHIV+ N  L  +        G+++NNR+  L+E  YF K +  S L +H+SPV + +  K ++ S+Y+ SRINV+PEK I +IL+E  +   ++S  + A+M++  FK + P +L+L T DEG  D  + ++ K +     A Y+G A   +N+  L+ VPLYLWGGDIGYF+ N+V RFMS +G+ELIFWMD    MRIGYD LPK +W +VV++NL  +DGIVW L   L CP KLC   + + D D Y  Y +AC   +L G  D K A   F+++P +IA  +PT+C + KQ      K I
Sbjct:    2 GVALLVLAYICL----STVTAIRFEQNPSPPQYAKPDQYGYRMCASWLLADGTPIYSGCDPFKTKRCGKELEFDYRCCSGFQHSNEPLGGPS--SNP-----CGKLIPQFDDCPSVIEEL-GFRKFASYLKNYPELTQRSGQPYTIFVPLPEDGGDLDRIY----GGNTRTVSYHVAKGRHYADDLRTGVKLKSIYNDEDIEISRTTYGA------KISQADIECKSGLIHIIRRPLVPRSGLGNLNKNSVMSLLQSNPETFEFANALPQELQQDLSRVEGGHFYTVTAPTSDSWSSLRGRYNREQLEAIAASHVSKGLKCTSNIIKGQQTFTDMQGQLMKVECSVNPSNRQEIRKITDACGDTHEFVDRQADLMAANGVVHVIRSPVIPMSQLTLKDLMDRPECA--KYQNIDKFIDVLRECDLYMDDASQYAVIAPENSAFDWWSGYAQFRPEYQRFQVDKEYRCEVARYHIVKHNGNLANIQDFSGHTDGHRSNNRNNYLYETTYFTKGKMGSTLNWHYSPVNNLQPLKLKNTSIYKTSRINVMPEKNITNILEERKDFSHTNSITKIAEMEEYVFKKKAPKNLYLVTTDEGWIDPRSRQLSKKLVSPELARYEGHATLAENFAKLNHVPLYLWGGDIGYFEKNSVHRFMSSAGVELIFWMDDKGTMRIGYDELPKSEWPKVVEYNLPGRDGIVWALDGFLRCPNKLCA--LQLEDKDTYTFYTAACLTSDLEGEVDVKRA---FSSKPTEIAKRHPTQCLVIKQGEVTTVKDI 749          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQ----KLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSG-TSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTE--NNAEMRYVSDLCGSKSKFVSQ--DNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRD-LLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKII-----AGYDGKAL--KNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKI 2483
            M+S +LI+    +     SA   + ++      +YA+PD+ GYR CA W+LADGT +YS CDPF  KRCGK LEF Y CC GFQ     LG  S  +NP     CAK +PQ+  CP V+    G  +FA  +K+   ++    Q +TIF P      +L +IY     G++  V YH+ KGR YA DL+   +L S+Y++++++V++ ++G + ++C E+++A++ECK+G+IH IR PL+PRSG  + D+++++  L+S+PET  FAND+P  LQ++L       +YT+ A  +++W +++ +Y   +LE I  +HV + L C++ + K+ +  T   G+ + VECS    N  E R V D CG   +F+ +  D MAANGV H+I  P+IP+S ++  D+++ P+CA       +KF + ++ CDL M    +YA++ P + +FDWW GY QF+PE+ RF  D+EYRC VARYHIV+ N  L  +        G+++NNR+  L+E  YF K +  S L +H+SPV +    K +D S+Y+ SRINV+PEK I DIL+E  +   + S  + A MD   FK + P +L+L T D+G  D  + ++ K +     A Y+G     +N+  L+ VPLYLWGGDIGYF+ N+V RFMS +G+EL+FWMD    MRIGYD LP+ +W +VV++N+  +DGI+W L   L CP KLC   + + D D Y  Y +AC   +L G  D K A   F ++P +IA  +P +C + +Q      K I
Sbjct:    1 MRSALLILAYLCY-----SAVTAIKFEQNPRPPQYADPDQYGYRMCASWQLADGTPIYSGCDPFKIKRCGKELEFDYRCCSGFQHSNEALGGTS--SNP-----CAKLVPQFDDCPSVIEGL-GFKKFATYLKNLPELTRQNGQPYTIFVPLPEGGGDLDRIY----GGNSQAVGYHIAKGRHYADDLKTGVKLKSLYRDEEMEVSRTTYGSVNVECTEISQADIECKSGLIHIIRHPLLPRSGLGNMDKSSVMSLLRSNPETREFANDLPQRLQQDLDRVDGGRFYTITAPTSDSWSSLRGQYNREQLEAIAASHVSAGLKCTSNIIKAEQIFTDMQGQLMKVECSVNPGNQQEERKVIDSCGETHEFIDKESDQMAANGVVHVISDPVIPMSQLTLKDLIDRPECAKHQ--NIDKFIDVLRKCDLYMDDASQYAVIAPENSAFDWWSGYRQFRPEFERFQVDEEYRCEVARYHIVKHNGNLANIPDFSGHTDGHRSNNRNNYLYETTYFTKGKMGSTLNWHYSPVNNLLPLKLKDSSIYKTSRINVMPEKNITDILQERTDFSHTKSITETAKMDDKVFKKKAPKNLYLVTTDDGWIDPRSRQLGKRLVSPELARYEGHPTLAENFAKLNHVPLYLWGGDIGYFEKNSVHRFMSSAGVELVFWMDDKGTMRIGYDELPRSEWPKVVEYNIPGRDGIIWALDGFLRCPNKLCA--LQLEDKDTYTFYTAACLSSDLEGEVDVKKA---FASKPTEIARRHPNQCLVIRQGEVTTVKDI 755          

Query:  318 QGYRYCAHWKLADGT--TLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVM-MKSPEMMSETPN--------QDFTIFAPDQVNNNELSKIYPTS---GQGSN------DPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSS-LQRELQNTRSKIWYTVLAVKNENWRAIKNKYFG------TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVAR---YHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDI 2075
            QG   CA  K+  GT    +++C  +  ++ CGK     Y+CC G++K                   +   K CP  L L    +   V+   + +M SE             FT FAP    +NE     PT       SN      + + YH+V  R  + DL++     S+YQ+  + +  YS G++ ++C  L K +    NG++H + + +   +      NN+   L+++ E  S    I ++ L   L+N  S   YT+ A  NE ++ I  +           L+ ++  H++  L+C+ ++   V  + T  G  + V C   +             K+    +D +  NGV H I + L+P SA +  ++       S++     K F    G    +   +   ++ P +   D +KG +   P   + L++   + + +    YH      ELE L    ++ + +   N   +        D+D                   R G+++ + +I   P   ++D+LK           VQKA + +L      P ++F  T ++  + +    ++K+    D + L   L  H    +L  G +
Sbjct:   38 QGPNVCAMQKI-QGTDKKYFTNCKQWYHRKICGKPTTIAYECCPGYEK-------------------VVGEKGCPAALPLLNIYNTLGVVGATTTKMYSERAKLQEEIEGPGSFTFFAP----SNEAWAALPTEILDALVSNVNIELLNALHYHMVNKRLTSDDLKHGSSFPSMYQDFDVHIHHYSNGIVTVNCARLVKTDQHATNGIVHVVDRVITAIT------NNVNAFLETEDELQSLQTAIAAAGLTSMLENEGS---YTIFAPTNEAFKKIPQEMLDRILGDPVALKDLLNYHIVKNLHCAESIVAGV-PLETLQGTVLEVGCDGNDMT--------LNGKAIVTEKDKLGTNGVVHYISELLVPDSAKTLKELAEGTPQVSTSI----KLF-MDAGLGAHLTGSETVTLIAPQN---DAFKGSATLTPSLRKALRNHILKNKFSSKSLYH----GQELETLGG--NKLRVFVYRNNLCIENACIAAHDKDG------------------RYGTMFTVDKILAPPMGTVMDVLKADSRFSILVDNVQKAGLTEL-LNKEGPYTIFAPT-NDAFRAMPPADLNKLT--RDPRELTKVLKYHIGEQFLVSGGV 576          

Query:  240 QNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPG--SSRFAVMMKSPEMMSETPNQDFTIFAP-----DQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF--ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFG--TELEKIVRNHVISKLYCSAALYK-SVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            Q  SSA + ++Y +++         +QG   CA  ++      Y S+C + +    CGK     Y+CC G+ +L          G + C    P   +    L L     + R++ + K  E +  +    +T+FAP     DQ++      +         + + YH+V  R    DL+N+ +L S++ NQ L +  YS G++ ++C  +  AN    NGV+H I + ++   G++       + + S+ E  S   A ++ S+L  +L        YT+ A  +  +    R +  +  G  T L+  ++ H+++ + CS A+   SV E  T  G  I + C     T N  +M             + +D + +NGV H+I++ L+P SA    +++   +    +            G    M  G +Y +L P++  F
Sbjct:   19 QVDSSAYDKIVYHSRI------RAKKQGPNMCALQQVMGTKKKYFSTCRNWYKGTICGKKAVVLYECCPGYMEL---------EGMRGCPAASP-IDNVYGTLGLLKADITKRYSDISKIKEEIDGSGT--YTMFAPTDDAWDQLDGTARKALEGNVNNELYNALHYHMVNKRLVTKDLKNDLKLESMHNNQGLHINHYSNGIVTVNCARIIHANQVATNGVVHLIDR-VISAVGSTIK-----EVINSNEELGSLSAAFNVESTLLEKLDQPG---HYTLFAPTDNAFDSMDREVIERVLGDQTVLKAFLKYHLLNSMQCSEAIMSGSVYE--TLEGSNIEIGCDGDSLTVNGIKM------------VLKKDIVTSNGVIHLIDQVLMPDSAKQVTELVGGSQSTFGDMVSE-------LGLSAAMGAGTQYTLLAPLNGVF 414          

Query:  240 QNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPG--SSRFAVMMKSPEMMSETPNQDFTIFAP-----DQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF--ANDIPSSLQRELQNTRSKIWYTVLAVKNENW----RAIKNKYFG--TELEKIVRNHVISKLYCSAALYK-SVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            Q  SSA + ++Y +++         +QG   CA  ++      Y S+C + +    CGK     Y+CC G+ +L          G + C    P   +    L L     + R++ + K  E +  +    +T+FAP     DQ++      +         + + YH+V  R    DL+N+ +L S++ NQ L +  YS G++ ++C  +  AN    NGV+H I + ++   G++       + + S+ E  S   A ++ S+L  +L        YT+ A  +  +    R +  +  G  T L+  ++ H+++ + CS A+   SV E  T  G  I + C     T N  +M             + +D + +NGV H+I++ L+P SA    +++   +    +            G    M  G +Y +L P++  F
Sbjct:   19 QVDSSAYDKIVYHSRI------RAKKQGPNMCALQQVMGTKKKYFSTCRNWYKGTICGKKAVVLYECCPGYMEL---------EGMRGCPAASP-IDNVYGTLGLLKADITKRYSDISKIKEEIDGSGT--YTMFAPTDDAWDQLDGTARKALEGNVNNELYNALHYHMVNKRLVTKDLKNDLKLESMHNNQGLHINHYSNGIVTVNCARIIHANQVATNGVVHLIDR-VISAVGSTIK-----EVINSNEELGSLSAAFNVESTLLEKLDQPG---HYTLFAPTDNAFDSMDREVIERVLGDQTVLKAFLKYHLLNSMQCSEAIMSGSVYE--TLEGSNIEIGCDGDSLTVNGIKM------------VLKKDIVTSNGVIHLIDQVLMPDSAKQVTELVGGSQSTFGDMVSE-------LGLSAAMGAGTQYTLLAPLNGVF 414          

Query:  210 ILIIFVFVFL-QNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYG--NQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAP-----DQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYF------GTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLH-TVPLYLWGG 2069
            +L +F+   L Q  SSA     YD  V+++R     ++G   CA  ++      Y S+C + +    CGK     Y+CC G+ KL    G P+     N YG    + A T  ++ S   +     GS                    +T FAP     D ++    + +         + + YH+   R    DLRN   + S+Y +  L +  YS G++ ++C  +   N    NGV+H I + +          N + D +  D E SS   +  ++    +        +T+ A  ++ +  +              L+ ++  H++  + CS A+  S     T  G  I + C     T N  +M             + +D +  NGV H+I++ L+P SA    +++   +   S+            G    M+P  +Y +L P++ +F       +      R LK       +   H+++    L +L            N + L      FL+   +       +  +   S +  +G+L+ +       E  +  +L EH   K   S ++ A +  L  K     +LF  T DE L  L+  + D  +   D  ALK  LL H +  +++ GG
Sbjct:    8 VLALFLLSALDQADSSA-----YDKIVAHSRI-RAKKEGPNVCALQQVMGTKKKYFSTCRNWYQGAICGKKATVLYECCPGYMKLEGMRGCPAVAPIDNVYGTLGLINAITTQEYSSLSKLREEIEGSG------------------SYTFFAPSNEAWDLLDAEVRNALVSNVNIELYNALHYHMANKRLLTKDLRNGLTVTSMYNDLSLHINHYSNGIVTVNCARIIHGNQVATNGVVHVIDRVITAVG------NTIQDVIDVDDELSSL--NTMATAAGLMDKLGQPGHFTLFAPTDDAFSKLDGDVMERLMADKDVLQALINYHLLDSVQCSEAIM-SGTSYETLEGTNIEIGCDGDSLTVNGVKM------------VLKKDIVTTNGVIHLIDQVLMPDSAKQVMELVGPSQSTFSDMVSE-------LGLSASMRPKAEYTLLAPLNSAFS-----DEVMSMDQRLLK------IILENHVLKSKIVLGQLY-----------NGQRLETLGGKFLRVFVYRTAVCIENACLIRGSKEGANGALHLMKTFIKPAESSMFKLLTEHGGFKIFLSLMEAAGLTDL-LKQEGDFTLFAPT-DEALSGLS--QRDIALLKSDPNALKAILLYHFSKGIFIGGG 576          

Query:  318 QGYRYCAHWKLADGTT--LYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDF----------------TIFAPD-----QVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDI 992
            +G   CA  ++ DGT+   +SSC  +  K+ CGK     Y+CC GF                    +I   K CP   ++ P S+ F    ++ E +  T  Q++                T FAP      ++    L  +     +   + ++YH+V  R  ASDL++   L S+Y+   + V  Y  G+I ++C  L K N    NGV+H I + + P S       NL   L+SD   ++    I
Sbjct:   39 EGANTCAVQQI-DGTSKRYFSSCKSWYQKKICGKPTTVSYECCPGF-------------------ISIEGEKGCP---AIAPLSNVF----RTLETVDATATQEYSQRAELRGELDGHATVTYFAPQNEGWTELPTEVLDALVSNVNRELRNALYYHMVNRRLLASDLKHGSTLTSMYEKLGVMVHHYPNGIITVNCARLLKPNNLATNGVVHVIDRVIAPPS------TNLRQILESDDNLATLRRRI 254          

Query:  714 HVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPL-VPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFGT--ELEKIVRNHVISKLYCSAALYKSVREIT-TSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIP 1346
            HV+KG+     L N QEL      +K+++  Y    ICI+   ++    E + G++H I K + VP         + L+ L++D   S+    I ++   E    RS    T+ A  NE + A+     N+  G   ELE ++  H+ S++  S  +    + +  T  G  + +E S +        S L   K K V  D MA +G  HII   L P
Sbjct:  444 HVIKGQVSLYQLYNGQEL-ETLGGKKIRIFIYR-KAICIENSCVSTMGKEGRLGILHVINKLIHVP-------ERSFLEILQADRRFSTLVELIRTAGLTE--KLRSAGRLTLFAPTNEAFAALPKAELNRLKGNPKELEALLNFHLASEVLVSGGIVGGAKNVLRTLHGGLLEIESSKDG-------SVLVNGK-KVVESDLMATSGAIHIISGVLTP 643          

Query:  711 YHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAI----KNKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFF 1409
            YH+V  R   SDLR+   L S Y+NQ L +  +S GV+ ++C  L + N    NGV+H I + +VP S      N + + ++   E  S    +  +    L ++   +  T+ A  NE    +     ++  G    L+ ++  H++  + CS +L      + T+ G    V     ++  +R          +   +D +  NGV H+I+  ++P SA    D+L   + +  N F
Sbjct:  100 YHMVSRRLLTSDLRDGLVLTSNYENQPLFINHHSNGVVTVNCARLIRPNFLATNGVVHTIDRVIVPVS------NRISEIVEFTAELESLKVLMEKAGMMPLLSSEGPL--TLFAPTNEAIERVPKETMDRIMGDPKTLKMVLEGHMMRSVICSESLLGEDVVLPTAGGAPALVASCQGSSIRLR-------GGGEVTRRDIVTTNGVVHLIDHLVLPDSA---RDVLEVAEDSGVNTF 320          

Query:  840 ELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIP-SSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGE-RISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSF 1505
            E+T+ ++   NGV+H I   ++P S       ++L+ +  D   ++F + +  S  + +LQ+  S   YT+L VK+           G +L++ +  HV+   Y S  L+   R  T + G  R+ +           Y   LC   S   ++D  A NG   I++KPL P            P+    N  +A+  F  +    LL   G    + MP+D + 
Sbjct:  280 EVTRRDIVTTNGVVHLIDHLVLPDSA-----RDVLE-VAEDSGVNTFMDLLEESGAKAQLQHEES---YTLLTVKDSAVTESFTADRGEKLKQKMLAHVVRGRYLSDRLFNGQRLETLAGGTLRVFI-----------YHRALCIESSCVDTKDRTARNGAIFILDKPLPP-----------PPRSTLMNMLEADTRFTML--VSLLRTAGFAEKLSMPVDLTI 470          

Query:  222 FVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKR-CGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQD------FTIFAPDQVNNNELSKIYPTSGQGSNDPVF-----YHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSF 980
             V   + N SS+      D  ++++R     E G   CA  ++ +G   +SSC  +  K+ C +     Y+CC G+  L          G   C   +P       + S++       + +    +       D      +T F P     NE  +  P + +  +  V       H V  R  +  L++   L S+   + + V +   G++ ++CV + K N+   NGV+H +   ++PR       NN+   L+ D E S+ 
Sbjct:   13 LVLWLVHNASSSA----IDRLLTHSRIRAIKE-GPNMCAVQQIENGKKYFSSCQLWYRKKICNRPATVSYECCPGYVSLS---------GQTGCPAIVP-------LNSIYKTVDGLGIKVTKARVDKADLGSDLDGPGAYTFFMP----TNEAWERIPAAAELEDPAVLKSLLLSHAVNKRLLSRHLKSGSALASMQSGRSIYVQQSPNGILTVNCVRVIKPNILATNGVLHMV-DGIIPRVS-----NNIRKILEEDSELSTL 246          

Query:  705 VFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPE--TSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRN----------HVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIP 1346
            + +HV+KG+ Y+S ++N+  L++  ++ +++   Y   ++   C  +TK NL   NGV+H + + +VP         N++  ++  P+  ++  A  + ++L   L+       +TV A  N  +  I  +    EL+KI+ N          HV+S  +CSA L    + + T SG  +++  S            +  +K+K V  D   +NGV H+I+  LIP
Sbjct:   81 LMFHVLKGKVYSSAIKNDL-LVASLEDSEIRFNIYG-KIVTAQCSLITKVNLNASNGVLHELSRVMVPPL-----YGNIVGFVREQPQHFSTLLAAVVEATLDGVLEGEGP---FTVFAPSNAAFTKIPKE----ELDKILHNIPLLTKILEYHVVSGTFCSAGLTDKAK-VETLSGSDVTIHVSK---------GGVMVNKAKVVFSDAPVSNGVVHVIDTVLIP 282          

Query:  705 VFYHVVKGRFYASDLRNNQELISVYQNQK-LKVTKYSFG-VICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDR--NNL---LDALKSDPETSSFANDI----PSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIP 1346
            + YHV++GR +A  ++N+    SV +    L +    +G ++   C  +TK NL   NGV+H + + ++P          NN+      LK   E +     +    P ++        SKI       K E  + +KN      L KI++ HV+S  +CSA L  + + + T +G  + +  + E       ++D    K +F   D   +NGV H IE  L+P
Sbjct:   38 LLYHVIRGRVFAGAIKNDMLEPSVVKTSPPLNIRFNVYGDIVTAQCSPITKVNLNASNGVLHELSRVMLPPGHGPITGLINNMPHPFSTLKIAIEKAGLGGALSGEGPFTIFAPTDGAFSKIP------KEELDKILKNIPL---LTKILKYHVVSGTFCSAGLTDNAK-LKTLAGSDVDIHVTKEG----VTIND--DGKVQF--ADASVSNGVLHAIEAVLLP 244          

Query:  426 YDCCVGFQKL-GPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSE-TPNQDFTIFAPDQVNNNELSKIYP--TSGQGSNDP------VFYHVVKGRFYASDLRNNQELISVYQNQKLKVT---KYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIW--YTVLAVKNENWRAI---------KNKYFGTELEKIVRNHVISKLYCSAAL----YKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDL---LMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLS--SLMHEQKGYK----TNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLAT 1946
            Y CC GF ++ G P      Y +++    +   KS         G S F  ++   E+ SE   +  +T F P    +NE  K  P  T    + DP      + +HV+  +  +  L++N  L ++     ++V    +    V  +   ++ +AN    NG+IH I + + P SG      NL+  L  +P+ S         +  E+ N+R+      T+ A  N   +++         KNK     L+K +  HV+ +   S  L    +KS+       G  + V    +N       + L  + +     D    +GV H+I+KPL+P  AM   + + +         K N   + ++   L   L      + +L P D++F      +    + SR   D E   +V  YH++ +     +    +L+   +G K    T     LH V+     R + +                 +  ++ IS + +  ++ + DI++  P   T +  ++K+ +  +     R ++LF  T
Sbjct:   93 YVCCPGFARVKGKPGCPEELYVSKM--NIVEVAKSL--------GLSEFVKLVNLAELGSELVLDTKYTAFIP----SNEAIKSIPAKTLEALAADPKKLRDVLLFHVLPEKVVSEALKHNMLLQTMDPPNDIRVNVNERTHPQVKVVQGAKIIQANQGASNGIIHVIDRVIFPSSG------NLMSYLNENPQLS---------MLYEVLNSRNMTLSNVTLFAPSNAALQSLPPGRLDKLLKNKQC---LQKFLTYHVLPEPLYSPVLRTCRWKSLE------GSFVGVMYGADN-------TSLEVNDAMVTIGDVSTTDGVIHVIDKPLMPYGAMDLVEAVKS--------LKLNTLAKLLEDSGLAKTLATIDTSFTLLAPTDKAFSAVP--ADVMADLSR---DAEKLKKVLTYHVIGRRVWTYEFGRDTLVDSLEGTKLRLNTFRLGKLHSVNGACLSRSNLETC---------------NSVIHVISSVLIPEQRTLYDIVRNEPQFTTLARILEKSSLSDMLKNSSRSITLFAPT 563          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDPFAFKR-CGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPE---TSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIK----NKYFG--TELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKD---KEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKF-RDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIV 2243
            Y T + ++R     +QG   CA  ++      Y ++C  +  ++ CGK     Y+CC G++K+    G P+     N Y       A T  Q+    D+ +   G   F     S    +  P +       + VN   L+ ++            YH+V  R  + +L++     S+YQ+  + +  Y  G+I ++C  L K +    NG++H + + +   + TS D   ++D ++ D E   T+  A  + + L+ E Q       YT+ A  NE +  I      +  G    L+ +++NH+I  ++C+ ++  S   + T  G  + V C  E              K+    +D +  NGV H I + LIP SA +  ++        S    A KFF    G    +   +   +L P++ +F   KG     P+  + L +   K+     + YH      ELE L  L      Y+ N                   L    S +     DK  R  S++ + ++ V P   I+D+LK           +Q A M +L    +  L+ F  T D   +++   +  +++   + + L + L LH     L  G I     ++  R +S  G +L   M       I  + +P      VV+ +L A +G+V
Sbjct:   23 YQTVLQHSRI-RGRQQGPNVCAMQQVKGSDKKYFTNCKQWYHRKICGKPTVITYECCPGYEKISGEKGCPAALPLVNIYNTLGVAGASTTQQYSERADLRNEIEGPGSFTFFAPSNGAWANLPTEILDALVSN-VNIELLNALH------------YHMVDQRLTSEELKHGSVFTSMYQDSTVHIHHYKNGIITVNCARLIKPDQHATNGIVHVVDRVI---TATSSDLQVMVD-IEDDLETLRTAMAAAGLTTMLEGEDQ-------YTIFAPTNEAFNKIPADTLTRILGDPVALKDLLKNHIIKHIHCAESIV-SGTPMETLQGTVLEVGCDGEQMT--------LNGKAIVTLKDKLGTNGVIHYINELLIPDSAKTLLEL-----AEGSTVSTATKFF-VDAGLSSRLTGSEALTMLAPLNEAF---KGSETMSPDLRKLLTNHILKDQLSSKSLYH----GQELETLGGLKLRVFVYRNN-------------------LCIENSCIA--AHDKVGRHASMFTVDKVLVPPMGTIMDVLKADNRFSMLVGAIQTAGMTEL-LNQQGALTFFAPT-DMAFREMPQAERSRLL--RNSQQLSSVLRLHVGDGVLVSGGI-----SSHVRLLSLQGEKLELNMRN---YTIYANKVP------VVEADLMATNGVV 616          

Query:  261 NNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDPF-AFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAP-----DQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIW-YTVLAVKNENWRAIKNKYFGTELEKIVRN----------HVISKLYCSAALYK-SVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLH-TVPLYLWGG 2069
            N+  YD  V+++R     ++G   CA  ++   +  Y S+C  +     CGK     Y+CC G+ K+          G + C    P        L L   ++      +S            T+FAP     D ++ NE  K+     Q   + + +H V  R    D++N   + ++ ++  L +  Y  GV+ ++C  +   N    NG +H I + + P SGT      + D L+   E  + ++   ++   +L +   +   YT+    +E +  + + Y    LE+I+ N          H+++ + C+ A+   SV E  T  G  I + C     T N  +M             + +D + +NGV H+I++ L P SA    +++   +    ++F    F          M+P  +Y +L P++  F   +  S  + E    L++   + +V+   +     +LE LS                      FL+   +       +  +   S + ++G+L+ +  +    +K +  +LK+    K   S ++ A +  +  K     ++F  T D+  K+LT+   D  +   D  ALKN LL H +  +++ GG
Sbjct:   21 NSSAYDKIVTHSRI-RARKEGPNVCALQQVMGTSKKYFSTCRNWHKGSICGKKAVVLYECCPGYMKI---------EGMKGCPAAAP-IDDVYGTLGLVKATATQQYTNESQLRGDIEGPTSVTLFAPSNDAWDLLDPNEKLKLAENENQELYNTLLFHTVNQRLVTKDMKNGLVVPTMSEDHNLYINHYGNGVVTVNCARIIYGNQVATNGAVHVIDRVIRPVSGT------IKDILE---ENENLSSFATAASAADLLDKLGEAGHYTLFVPTDEAFDKLPSGY----LERIIENNAVITALVKYHLLNSVQCAEAIMAGSVYE--TEEGSSIEIGCDGDFLTVNGIKM------------VLKKDIVTSNGVIHLIDQVLFPDSAKEITELMGESQSYFRDYFSEMDFAS-------AMRPNLEYTLLAPLNGVFT-EEVSSIAKSELKLLLENHILKVKVSLSELY-TGQQLETLSG--------------------KFLRAFIYRTAVCLENACMVRGSKEGKNGALHLVGSLVKTSDKTLYKVLKDEGQFKIFLSLMEAAGLYDM-LKEEGAYTIFAPT-DDAFKELTSE--DLTLLKSDVTALKNILLYHISNGIFISGG 576          

Query:  261 NNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSCDPF-AFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAP-----DQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIW-YTVLAVKNENWRAIKNKYFGTELEKIVRN----------HVISKLYCSAALYK-SVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLH-TVPLYLWGG 2069
            N+  YD  V+++R     ++G   CA  ++   +  Y S+C  +     CGK     Y+CC G+ K+          G + C    P        L L   ++      +S            T+FAP     D ++ NE  K+     Q   + + +H V  R    D++N   + ++ ++  L +  Y  GV+ ++C  +   N    NG +H I + + P SGT      + D L+   E  + ++   ++   +L +   +   YT+    +E +  + + Y    LE+I+ N          H+++ + C+ A+   SV E  T  G  I + C     T N  +M             + +D + +NGV H+I++ L P SA    +++   +    ++F    F          M+P  +Y +L P++  F   +  S  + E    L++   + +V+   +     +LE LS                      FL+   +       +  +   S + ++G+L+ +  +    +K +  +LK+    K   S ++ A +  +  K     ++F  T D+  K+LT+   D  +   D  ALKN LL H +  +++ GG
Sbjct:   21 NSSAYDKIVTHSRI-RARKEGPNVCALQQVMGTSKKYFSTCRNWHKGSICGKKAVVLYECCPGYMKI---------EGMKGCPAAAP-IDDVYGTLGLVKATATQQYTNESQLRGDIEGPTSVTLFAPSNDAWDLLDPNEKLKLAENENQELYNTLLFHTVNQRLVTKDMKNGLVVPTMSEDHNLYINHYGNGVVTVNCARIIYGNQVATNGAVHVIDRVIRPVSGT------IKDILE---ENENLSSFATAASAADLLDKLGEAGHYTLFVPTDEAFDKLPSGY----LERIIENNAVITALVKYHLLNSVQCAEAIMAGSVYE--TEEGSSIEIGCDGDFLTVNGIKM------------VLKKDIVTSNGVIHLIDQVLFPDSAKEITELMGESQSYFRDYFSEMDFAS-------AMRPNLEYTLLAPLNGVFT-EEVSSIAKSELKLLLENHILKVKVSLSELY-TGQQLETLSG--------------------KFLRAFIYRTAVCLENACMVRGSKEGKNGALHLVGSLVKTSDKTLYKVLKDEGQFKIFLSLMEAAGLYDM-LKEEGAYTIFAPT-DDAFKELTSE--DLTLLKSDVTALKNILLYHISNGIFISGG 576          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWKLADGTT--LYSSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYF------GTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIK--GCDLLMKPGKKYAILMPIDRSF 1505
            YD  ++++R     ++G   CA  ++  GT    +S+C + +    CGK     Y+CC G+ KL    G P+     + YG+   V A +  ++     V     GS  F     S E   E  ++D        VN     ++Y        + + YH+   R    DL+N   + S+Y +  L +  YS GV+ ++C  +   N    NGV+H I + +      S   N++ D ++ + + ++ ++   +S    L+       YT+ A  N+ +  + +            L+ ++  H++  + CS A+        T  G  I + C     T N  +M             + +D +  NGV H+I++ L+P SA    ++L + +         + F + I   G    M    +Y  L P++  F
Sbjct:   23 YDKILTHSRI-RAKKEGPNVCALQQVM-GTKKKYFSTCRNWYHGAICGKKATVLYECCPGYIKLDGMRGCPAVAPIDHVYGSLGIVKASSTQKYADISKVRPEIEGSGSFTFFAPSNEAW-ELLDEDVRNALVSNVN----IELY--------NALHYHMANKRLLTKDLKNGMTITSMYNDLDLHINHYSNGVVTVNCARIISGNQIATNGVVHVIDRVI------SAIGNSMQDVIEVEDDLTTLSDLAQTS--GLLEKLGQPGHYTLFAPTNDAFDKLGSDVLERLQSDKEVLKALLSFHLLDSVQCSEAIMVG-SSYETLEGNSIEIGCDGDSLTVNGVKM------------VLKKDIVTKNGVIHLIDQVLLPDSAKQVMELLGSSQ---------STFGDMISELGISTSMASDAEYTFLAPLNDVF 411          

Query:  273 YDTQVSNARYAEPDEQGYRYCAHWKLADGTTLY-SSC-DPFAFKRCGKTLEFGYDCCVGFQKL----GPPSFE--TNPYGNQ--VCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYF------GTELEKIVRNHVISKLYCSAALYKSVREITTSSGERISVECS----TENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIK--GCDLLMKPGKKYAILMPIDRSF 1505
            YD  ++++R     ++G   CA  ++      Y S+C + +    CGK     Y+CC G+ KL    G P+     + YG+   V A +  ++     V     GS  F     S E   E  ++D        VN     ++Y        + + YH+   R    DL+N   + S+Y +  L +  YS GV+ ++C  +   N    NGV+H I + +      S   N++ D ++ + + ++ ++   +S    L+       YT+ A  N+ +  + +            L+ ++  H++  + CS A+        T  G  I + C     T N  +M             + +D +  NGV H+I++ L+P SA    ++L + +         + F + I   G    M    +Y  L P++  F
Sbjct:   23 YDKILTHSRI-RAKKEGPNVCALQQVMGTKKKYFSTCRNWYHGAICGKKATVLYECCPGYIKLDGMRGCPAVAPIDHVYGSLGIVKASSTQKYADISKVRPEIEGSGSFTFFAPSNEAW-ELLDEDVRNALVSNVN----IELY--------NALHYHMANKRLLTKDLKNGMTITSMYNDLDLHINHYSNGVVTVNCARIISGNQIATNGVVHVIDRVI------SAIGNSMQDVIEVEDDLTTLSDLAQTS--GLLEKLGQPGHYTLFAPTNDAFDKLGSDVLERLQSDKEVLKALLSFHLLDSVQCSEAIMVG-SSYETLEGNSIEIGCDGDSLTVNGVKM------------VLKKDIVTKNGVIHLIDQVLLPDSAKQVMELLGSSQ---------STFGDMISELGISTSMASDAEYTFLAPLNDVF 411          

Query: 1242 MRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP 2489
            MRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPV+DFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWLLKRPLPCPPKLCPHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP
Sbjct:    1 MRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVMDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWLLKRPLPCPPKLCPHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP 416          

Query: 1299 MAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWXXXXXXXXXXXXXXHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP 2489
            MAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPV+DFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWLLKRPLPCPPKLCPHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP
Sbjct:    1 MAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKANKFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVMDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMSRSGIELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVWLLKRPLPCPPKLCPHKIVIMDYDLYDVYVSACQIMELPGIKDAKDAKLQFNARPIKIALDNPTKCSIYKQPTHKVTKKISP 397          

Query:  198 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYP 677
            MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYP
Sbjct:    1 MKSLILIIFVFVFLQNKSSAQNNVIYDTQVSNARYAEPDEQGYRYCAHWKLADGTTLYSSCDPFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKSPEMMSETPNQDFTIFAPDQVNNNELSKIYP 160          

Query:  679 LLVKEAMIQCFIMSLKVDFMHRIFEIIRN 765
            +LVKEAMIQCFIMSLKVDFMHRIFEIIRN
Sbjct:  161 ILVKEAMIQCFIMSLKVDFMHRIFEIIRN 189          

Query:  333 CAHWKLADGTTLYS--SCD-PFAFKRCGKTLEFGYDCCVGFQKLGPPSFETNPYGNQVCAKTIPQWKSCPDVLSLFPGSSRFAVMMKS----PEMMSETPNQDFTIFAPDQVNNNELSKIYPTSGQGSNDPVFYHVVKGRFYASDLRNNQELISVYQNQKLKVTKYSFGVICIDCVELTKANLECKNGVIHFIRKPLVPRSGTSFDRNNLLDALKSDPETSSFANDIPSSLQRELQNTRSKIWYTVLAVKNENWRAIKNKYFGTELEKIVRNHVISKLYCSAALYKSVREITTS-SGERISVECSTENNAEMRYVSDLCGSKSKFVSQDNMAANGVYHIIEKPLIPLSAMSFNDILNNPKCASSNFFKAN--KFFEFIKGCDLLMKPGKKYAILMPIDRSFDWWKGYSQFQPEYSRFLKDKEYRCRVARYHIVEQNPELEKLSSLMHEQKGYKTNNRDLLHEVDYFLKDRDHSDLYFHFSPVVDFKSDKFRDGSLYRISRINVIPEKFIVDILKEHPNLKTSSSQVQKADMDKLEFKPRRPLSLFLATLDEGLKDLTTGKIDKIIAGYDGKALKNYLLLHTVPLYLWGGDIGYFKPNTVQRFMS---RSG--IELIFWMDKNQVMRIGYDGLPKEKWAEVVKFNLHAKDGIVW 2246
            CA  K + G   YS  +C  PF    C     F Y CC GF K        +P  +  C++    WK  P  L  +    +FA +++      ++  E     +T+ AP   +  +L +   ++  G   P+  H+ K R Y++   N     ++  + KLKVT YS G++ IDC  L   + E KNGVIH+I  P+ P  G+ + R  +L A+++DP T+SF NDI S L+  L       W TV A  N  W A K+KY G+++  +V+NH+++++ C+ A+ K    +  S + E + V+CS++ +   R + D CG+K++ + +D ++ NGV  II+  L+P SAMS  D ++   C S+   K++   F +  + CDL +    KY +L+P + +  W +  S++  E S+   ++EY+C+V RYH+++   +     + M          +  L  V YF+KDRD S LYF+ +     +  KF  G ++ + RIN+ P K ++ +L E P++K ++ ++Q    D    K      LFLA  + G +     +       +    L     LHT+ + LWG D+GYF P T+    S    SG   +L    + N  + IGY+GLP E W+ V++ NLH  DG++W
Sbjct:   43 CAFLKPSQGLLPYSFWTCGVPFKQTYCESETTFEYQCCPGFTK--------SPLVDNQCSEVESVWKIIPVHLKDY-SVPKFAKLLEKHSQIKDLFEENGRDTYTVLAPYSDDAMKLGEFDLSNVGGFPHPITMHIGKNRMYSNQFVNGATFKTLSDDHKLKVTTYSNGLVFIDCRALVNPDHEAKNGVIHYISGPITPHVGSGYQRKTVLQAMQNDPLTNSFYNDIQSELREILDQESDGQWLTVFAPSNTAWEAAKSKY-GSKISLLVKNHILNRMICAQAITKKATSLGPSLANEYLGVDCSSDKS---RSILDACGNKARIIKEDLVSGNGVVQIIDSVLVPTSAMSAKDAVS---CLSTGDPKSDVSSFLQHSRSCDLKINSFSKYILLIPTNEAHTWLQEQSKYSNENSQMSSNEEYKCQVLRYHVLKMKGDTPAFVNQMSFDTNLDNGGKP-LSVVTYFVKDRDGSKLYFNAARTTKLEPRKFAQGIIFFVDRINIPPSKTMMQLLSERPDVKLTTEKLQDTGYDS-RIKSFGHNVLFLAWQNHGWQTRKEKE-------WGSSELNRLFQLHTIKMELWGSDMGYFYPETLSTVNSAYLESGNPFQLQIKRELNGNIFIGYEGLPFELWSLVIESNLHGTDGMLW 670