haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

Overview


Name	haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1
Smed ID	SMED30000009
Length (bp)	3477

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 (SMED30000009) t-SNE clustered cells

Violin plots show distribution of expression levels for haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 (SMED30000009) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 (SMED30000009) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30000009

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30000009	h1SMcG0022400	dd_Smed_v4_3674_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30000009	h1SMcG0022400	dd_Smed_v4_3674_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30000009	h1SMcG0022400	dd_Smed_v4_3674_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30000009	h1SMcG0002499	dd_Smed_v4_9053_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
epidermis	SMED30000009	h1SMcG0001223	dd_Smed_v4_9053_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
epidermis	SMED30000009	h1SMcG0022400	dd_Smed_v4_9053_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Human
Match: HDHD5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:HGNC Symbol;Acc:HGNC:1843])

HSP 1 Score: 297.745 bits (761), Expect = 2.944e-90
Identity = 170/430 (39.53%), Postives = 238/430 (55.35%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRI-PAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF 1474
            +G  +IP A +AF  L++  G+ +VP VFVTNAGN L+  KA +LS     ++  DQV++SHSP+++F+++H+KR+LV GQGPV   A  LGFRN VTV++L++ +P LD  +  RR+   P     + + IE ++L GEP RWETSLQ+I+D+LL+NG P         L  P    PYPHLP+LA NMD+ WMAEA +PR GHG FLL LE++Y+K++ ++L Y GL+GKPS +TY YAE  + + A+   G   PI+ +Y +GDNP +DVYGANL+++YL            +KA H                             +  PE  +           G     +   ++ CISILV TGV    NP     ++         H HRD    P L    HV + V EAV   F KE +  
Sbjct:   29 RGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPR-IEGVLLLGEPVRWETSLQLIMDVLLSNGSP------GAGLATP----PYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAER-RGWAAPIRKLYAVGDNPMSDVYGANLFHQYL------------QKATH-----------------------------DGAPELGA-----------GGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLG--GGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWAL 392

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Human
Match: HDHD5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:HGNC Symbol;Acc:HGNC:1843])

HSP 1 Score: 297.36 bits (760), Expect = 8.588e-90
Identity = 170/430 (39.53%), Postives = 238/430 (55.35%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRI-PAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF 1474
            +G  +IP A +AF  L++  G+ +VP VFVTNAGN L+  KA +LS     ++  DQV++SHSP+++F+++H+KR+LV GQGPV   A  LGFRN VTV++L++ +P LD  +  RR+   P     + + IE ++L GEP RWETSLQ+I+D+LL+NG P         L  P    PYPHLP+LA NMD+ WMAEA +PR GHG FLL LE++Y+K++ ++L Y GL+GKPS +TY YAE  + + A+   G   PI+ +Y +GDNP +DVYGANL+++YL            +KA H                             +  PE  +           G     +   ++ CISILV TGV    NP     ++         H HRD    P L    HV + V EAV   F KE +  
Sbjct:   59 RGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPR-IEGVLLLGEPVRWETSLQLIMDVLLSNGSP------GAGLATP----PYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAER-RGWAAPIRKLYAVGDNPMSDVYGANLFHQYL------------QKATH-----------------------------DGAPELGA-----------GGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLG--GGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWAL 422

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Human
Match: HDHD5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:HGNC Symbol;Acc:HGNC:1843])

HSP 1 Score: 81.6481 bits (200), Expect = 1.279e-16
Identity = 39/70 (55.71%), Postives = 48/70 (68.57%), Query Frame = 2

Query:  578 IEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLP 787
            IE ++L GEP RWETSLQ+I+D+LL+NG P         L  P    PYPHLP+LA NMD+ WMAEA +P
Sbjct:   52 IEGVLLLGEPVRWETSLQLIMDVLLSNGSP------GAGLATP----PYPHLPVLASNMDLLWMAEAKMP 111

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Celegans
Match: H32C10.1 (pep chromosome:WBcel235:IV:5934346:5937497:1 gene:WBGene00019255.1 transcript:H32C10.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:H32C10.1)

HSP 1 Score: 252.292 bits (643), Expect = 4.599e-74
Identity = 151/434 (34.79%), Postives = 236/434 (54.38%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNK---PIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYP-HLPILACNMDMQWMAE--APLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISE-EIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR+++P  K+AF+L+ D+ G + VP VF+TN  N   K KA  LSE+   ++  D V+MSHSPLRMFT  H K+VLV GQ   + IA  +GF+   T++ L   +PHLD  + +R++  P   E   K   PIEAI++ GEP +WETSLQ++LD +LT G+       +T +   ++    P H+PI+ACN+D+ WMA+  + LPR+GHG F+  L+SLYEKL+ + L +   +GKP+EV+Y +A +R+ + A+        +K++Y IGDNP +DV GA L++RYL      R    ++E    + G+K        PR +                                          E+CISILV TGV +  + + IN ++K I+    N +     +  +L++P  V + ++ A+     +E +
Sbjct:   33 RGRNMLPRVKEAFSLITDKKGNFVVPTVFLTNGTNSTEKNKAAQLSEQLGFRVPADNVLMSHSPLRMFTDLHDKQVLVVGQKNARAIAKGVGFKKVTTIDHLVKWFPHLDCTDFSRKLVDPKETEAARKRFRPIEAIVMLGEPLKWETSLQLMLDCVLTYGK------MDTMVFPLIAGGRRPDHIPIVACNVDLVWMADVASQLPRIGHGTFIHILDSLYEKLTGQHLQFRATLGKPTEVSYLHAAHRIQRQAKAMK--LEDVKYVYVIGDNPMSDVLGARLFDRYLRHGGVGRFDHLDLEAFDVNDGEK--------PRVRTRN-------------------------------------VVERCISILVETGVHQ--DHVHINGMVKPISALIDNLSK---GEQLKLQLPDFVEYDLHAAIRTILRRECY 408

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Celegans
Match: H32C10.1 (pep chromosome:WBcel235:IV:5934444:5937497:1 gene:WBGene00019255.1 transcript:H32C10.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:H32C10.1)

HSP 1 Score: 246.128 bits (627), Expect = 6.574e-72
Identity = 151/439 (34.40%), Postives = 236/439 (53.76%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIAT-----MLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNK---PIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYP-HLPILACNMDMQWMAE--APLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISE-EIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR+++P  K+AF+L+ D+ G + VP VF+TN  N   K KA  LSE+   ++  D V+MSHSPLRMFT  H K+VLV GQ   + IA       +GF+   T++ L   +PHLD  + +R++  P   E   K   PIEAI++ GEP +WETSLQ++LD +LT G+       +T +   ++    P H+PI+ACN+D+ WMA+  + LPR+GHG F+  L+SLYEKL+ + L +   +GKP+EV+Y +A +R+ + A+        +K++Y IGDNP +DV GA L++RYL      R    ++E    + G+K        PR +                                          E+CISILV TGV +  + + IN ++K I+    N +     +  +L++P  V + ++ A+     +E +
Sbjct:   33 RGRNMLPRVKEAFSLITDKKGNFVVPTVFLTNGTNSTEKNKAAQLSEQLGFRVPADNVLMSHSPLRMFTDLHDKQVLVVGQKNARAIAKGIIFFRVGFKKVTTIDHLVKWFPHLDCTDFSRKLVDPKETEAARKRFRPIEAIVMLGEPLKWETSLQLMLDCVLTYGK------MDTMVFPLIAGGRRPDHIPIVACNVDLVWMADVASQLPRIGHGTFIHILDSLYEKLTGQHLQFRATLGKPTEVSYLHAAHRIQRQAKAMK--LEDVKYVYVIGDNPMSDVLGARLFDRYLRHGGVGRFDHLDLEAFDVNDGEK--------PRVRTRNV-------------------------------------VERCISILVETGVHQ--DHVHINGMVKPISALIDNLSK---GEQLKLQLPDFVEYDLHAAIRTILRRECY 413

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Zebrafish
Match: hdhd5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:ZFIN;Acc:ZDB-GENE-080220-59])

HSP 1 Score: 333.954 bits (855), Expect = 3.216e-103
Identity = 188/428 (43.93%), Postives = 256/428 (59.81%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKP-IEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR+ IP AKQ F  L+D  GK+KVP VFVTNAGN LR+ KA  LS   ++++ P+QVV+SHSPLR+FTQFH   VLV GQGPV  +A  +GF+N VT++ L+  YP LD  +H+RR P     +T + P I+A+ILFGEP RWET+LQ+I+D+LLTNG+P            PV+ + YPH+P+LACNMD+ WMAEA  PR GHG FL+ LES+Y+K++  +L Y  LIGKPS VTY+YAE  + + A+   G   P++ +Y IGDNP  D+YGANLYNRYL+A   SR  +   +A+  +  ++    H      + Q  VG +  E+ +PE                           C SILV TGV   + P D     + +T+  + H HRDF   P L  P  + + V + V   F  E +
Sbjct:   61 RGRTPIPAAKQCFRNLVDGDGKYKVPVVFVTNAGNALRQTKAEQLSHLLEVEVSPEQVVLSHSPLRVFTQFHDMCVLVSGQGPVVEVAHNVGFKNVVTIDMLREAYPLLDVVDHHRR-PKDTIPQTKDLPHIDAVILFGEPIRWETNLQLIVDVLLTNGRP----------GNPVTSLHYPHIPVLACNMDLLWMAEAKNPRFGHGMFLVCLESIYKKITGCELKYEALIGKPSVVTYNYAELLIREQAEKL-GWTRPVQRLYAIGDNPMADIYGANLYNRYLKAMNRSRTPQ--VQAQGGVSGQMAADLHCDDAKCSGQVMVGGSF-EHCLPEA--------------------------CSSILVCTGVYNRDMPTDPQ---ETLTEHRIFHGHRDFRFDPSLTQPSFIVNDVRDGVELVFQLEGW 444

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Zebrafish
Match: zgc:77375 (zgc:77375 [Source:ZFIN;Acc:ZDB-GENE-040426-1827])

HSP 1 Score: 314.309 bits (804), Expect = 3.684e-96
Identity = 184/431 (42.69%), Postives = 246/431 (57.08%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKS-THIESEYSQIIGNETVIKAGFAEKCISILVLTGVIR--INNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFG 1471
            +G++ IP AK+AF  L+D  G++ VP VFVTNAGN LR++KA  LS    + I  DQV+MSHSPLRMF ++H K VLV GQGPV  IA  +GF N V+++ L+  +P LD  +HNRR   P +       +EA++LFGEP RWET+LQ+I+D+LLTNG        N +     +H    HLP+LACNMD+ WMAEA  PR GHG F++ LES+Y+K++ ++L Y  L+GKPSE+TYH+AE+ + + A +  G   PI+ +Y IGDN  TD+YGANLYNRYLE     R+S    KA                             + N++  T +   +  E     G E+ + +  A  C SILV TGV    +  P D +  IK      V H HRDF   P L  P  +   V  AV   F  E FG
Sbjct:   44 RGKTPIPAAKRAFQKLVDTKGQFLVPVVFVTNAGNCLRQKKADQLSHILGVPISQDQVMMSHSPLRMFKKYHDKFVLVSGQGPVLDIAKNVGFTNVVSIDMLRESFPLLDMVDHNRRPKLPSSPVANLPRVEAVVLFGEPIRWETNLQLIVDVLLTNG--------NLSSAYETAH--STHLPLLACNMDLMWMAEAHSPRFGHGTFMVCLESIYKKITGKELKYEALMGKPSELTYHFAEFLIREQAVE-RGWRAPIRSLYAIGDNLMTDIYGANLYNRYLE----DRVSRTSTKA-----------------------------VANMVTGTGAPASVPEEVETGNGWESELASPSATSCKSILVCTGVYNPHMELPRDASQCIK----ETVFHGHRDFRFDPALVEPEKIVQDVDAAVELIFQMEKFG 426

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Zebrafish
Match: hdhd5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:ZFIN;Acc:ZDB-GENE-080220-59])

HSP 1 Score: 217.238 bits (552), Expect = 2.927e-63
Identity = 110/202 (54.46%), Postives = 144/202 (71.29%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKP-IEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPR 790
            +GR+ IP AKQ F  L+D  GK+KVP VFVTNAGN LR+ KA  LS   ++++ P+QVV+SHSPLR+FTQFH   VLV GQGPV  +A  +GF+N VT++ L+  YP LD  +H+RR P     +T + P I+A+ILFGEP RWET+LQ+I+D+LLTNG+P            PV+ + YPH+P+LACNMD+ WMAEA  PR
Sbjct:   61 RGRTPIPAAKQCFRNLVDGDGKYKVPVVFVTNAGNALRQTKAEQLSHLLEVEVSPEQVVLSHSPLRVFTQFHDMCVLVSGQGPVVEVAHNVGFKNVVTIDMLREAYPLLDVVDHHRR-PKDTIPQTKDLPHIDAVILFGEPIRWETNLQLIVDVLLTNGRP----------GNPVTSLHYPHIPVLACNMDLLWMAEAKNPR 251

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Xenopus
Match: hdhd5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:NCBI gene;Acc:100101802])

HSP 1 Score: 308.916 bits (790), Expect = 1.490e-94
Identity = 151/287 (52.61%), Postives = 196/287 (68.29%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQG 1048
            +G+  IP A +AF  L+ R G+  VP VFVTNAGN +R+ +A +LS    +++ P+QV++SHSPL M  QFH K VL+ GQGPV  IA   GFRN VT+ DL++ YP LD  +HNRR   P         IEA+IL GEP RWETSLQ+ILD+LL+NG+P   L            VPYPH+P+LACNMD+ WMAEA  PR GHG FL+ LE+LY KL+ ++L Y  LIGKPS VTY +A++ + + A+   G N PI+ +Y IGDNP  D+YGANLYNR+L++ QG
Sbjct:   19 RGKKPIPGAAEAFQKLVGRDGRMTVPVVFVTNAGNCVRQTRATELSRVLGVEVLPEQVILSHSPLLMLEQFHDKCVLMSGQGPVAEIAKDQGFRNVVTINDLRMAYPLLDMVDHNRRPKNPTPVIQNFPAIEAVILLGEPVRWETSLQLILDVLLSNGRPTAWL----------PQVPYPHIPVLACNMDLLWMAEAKNPRFGHGTFLVCLETLYHKLTGQELRYEALIGKPSRVTYSFAQHLILEQARK-RGWNAPIRTLYAIGDNPMADIYGANLYNRFLKSNQG 294

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Mouse
Match: Hdhd5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:MGI Symbol;Acc:MGI:2136976])

HSP 1 Score: 298.13 bits (762), Expect = 2.930e-90
Identity = 168/428 (39.25%), Postives = 237/428 (55.37%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVN-HNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G  +IP A +AF+ L++  G+ +VP VFVTNAGN L+  KA +LS+  + K+ PDQV++SHSP+++F Q+H K++LV GQGP+   A  LGF+N VT+++L+L +P LD  +  RR P      +    IE ++L GEP RWET+LQ+I+D+LL+NG P       T L       PYPHLP+LA NMD+ WMAEA +PR GHG FLL LE++Y K++  +L Y GL+GKPS +TY YAE  + + A+   G   PI+ +Y IGDNP +DVYGANL+++YL  Q  +R  EE                                                   Q  G +   +    + C SILV TG+    +P    S +    +  +  H HRDF   P L    H+ H V EAV   F++E +
Sbjct:   59 RGHRVIPAALEAFSKLVNSQGQLRVPVVFVTNAGNILQHNKAQELSDLLRCKVDPDQVILSHSPMKLFLQYHSKQMLVSGQGPLVENARALGFQNVVTIDELRLAFPELDMVDLQRR-PKTMRLRSDFPAIEGVLLLGEPVRWETNLQLIMDVLLSNGHP------GTGLAT----APYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYRKITGNELKYEGLMGKPSILTYQYAEDVIRQQAER-RGWAAPIRKLYAIGDNPMSDVYGANLFHQYL--QMANRGEEE---------------------------------------------------QQTGGQQKQRPSATQSCASILVCTGIYSSQDP---GSQVPPPGRRELPFHGHRDFSFSPGLLEASHIVHDVNEAVQLVFHQEGW 418

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
Match: sp|Q91WM2|HDHD5_MOUSE (Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Mus musculus OX=10090 GN=Hdhd5 PE=1 SV=1)

HSP 1 Score: 298.13 bits (762), Expect = 2.050e-89
Identity = 168/428 (39.25%), Postives = 237/428 (55.37%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVN-HNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G  +IP A +AF+ L++  G+ +VP VFVTNAGN L+  KA +LS+  + K+ PDQV++SHSP+++F Q+H K++LV GQGP+   A  LGF+N VT+++L+L +P LD  +  RR P      +    IE ++L GEP RWET+LQ+I+D+LL+NG P       T L       PYPHLP+LA NMD+ WMAEA +PR GHG FLL LE++Y K++  +L Y GL+GKPS +TY YAE  + + A+   G   PI+ +Y IGDNP +DVYGANL+++YL  Q  +R  EE                                                   Q  G +   +    + C SILV TG+    +P    S +    +  +  H HRDF   P L    H+ H V EAV   F++E +
Sbjct:   59 RGHRVIPAALEAFSKLVNSQGQLRVPVVFVTNAGNILQHNKAQELSDLLRCKVDPDQVILSHSPMKLFLQYHSKQMLVSGQGPLVENARALGFQNVVTIDELRLAFPELDMVDLQRR-PKTMRLRSDFPAIEGVLLLGEPVRWETNLQLIMDVLLSNGHP------GTGLAT----APYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYRKITGNELKYEGLMGKPSILTYQYAEDVIRQQAER-RGWAAPIRKLYAIGDNPMSDVYGANLFHQYL--QMANRGEEE---------------------------------------------------QQTGGQQKQRPSATQSCASILVCTGIYSSQDP---GSQVPPPGRRELPFHGHRDFSFSPGLLEASHIVHDVNEAVQLVFHQEGW 418

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
Match: sp|Q9BXW7|HDHD5_HUMAN (Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1)

HSP 1 Score: 297.36 bits (760), Expect = 4.124e-89
Identity = 170/430 (39.53%), Postives = 238/430 (55.35%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRI-PAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF 1474
            +G  +IP A +AF  L++  G+ +VP VFVTNAGN L+  KA +LS     ++  DQV++SHSP+++F+++H+KR+LV GQGPV   A  LGFRN VTV++L++ +P LD  +  RR+   P     + + IE ++L GEP RWETSLQ+I+D+LL+NG P         L  P    PYPHLP+LA NMD+ WMAEA +PR GHG FLL LE++Y+K++ ++L Y GL+GKPS +TY YAE  + + A+   G   PI+ +Y +GDNP +DVYGANL+++YL            +KA H                             +  PE  +           G     +   ++ CISILV TGV    NP     ++         H HRD    P L    HV + V EAV   F KE +  
Sbjct:   59 RGHRVIPAALKAFRRLVNSQGQLRVPVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRLKTTPLPRNDFPR-IEGVLLLGEPVRWETSLQLIMDVLLSNGSP------GAGLATP----PYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKVTGKELRYEGLMGKPSILTYQYAEDLIRRQAER-RGWAAPIRKLYAVGDNPMSDVYGANLFHQYL------------QKATH-----------------------------DGAPELGA-----------GGTRQQQPSASQSCISILVCTGVYNPRNPQSTEPVLG--GGEPPFHGHRDLCFSPGLMEASHVVNDVNEAVQLVFRKEGWAL 422

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
Match: sp|O13899|YF38_SCHPO (Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC22A12.08c PE=3 SV=1)

HSP 1 Score: 113.62 bits (283), Expect = 1.527e-24
Identity = 76/258 (29.46%), Postives = 122/258 (47.29%), Query Frame = 2

Query:  260 VPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQ-GPVKTIATMLGFRNAVTVEDL--QLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYN 1024
            +P + +TN G      +A  LS+   + +  D    SH+P R     +K  +++ G+   V+  A   GF++ +   D+  +L  P       N             +PIEA+  + +P R    LQ+++++    GQ          +   VS        I   N D+ W  E PLPRLG G F +  ES++++L+ + L  T   GKP ++TY YA+  L K  +   GI NP K I+ +GDNP++D+ GAN Y 
Sbjct:   71 IPFILLTNGGGMHESVRAQRLSKTLSVSLTEDDFCQSHTPFRALADKYKHVLVLGGKDNSVRETAEKYGFKSVINELDVIAKLGTPFWPFTSFNEEDIKDAKDFDVTRPIEAVFTYVDPVRLGLDLQLVMEL----GQS------KNGVLGTVSKTANEGPDIYFSNADLIWPNEYPLPRLGQGAFAICCESVFKELTGKDLRNTKY-GKPHKLTYDYAKNILMKKHKTL-GITNPPKEIFMVGDNPESDIRGANNYG 316

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
Match: sp|P36151|YK50_YEAST (Uncharacterized protein YKR070W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YKR070W PE=1 SV=1)

HSP 1 Score: 107.071 bits (266), Expect = 1.851e-23
Identity = 87/306 (28.43%), Postives = 139/306 (45.42%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDA----------CEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLH-YTGLIGKPSEVTYHYA-------EYRLN-KIAQDFHG---------INNPIKHIYCIGDNPQTDVYGANLY 1021
            +G+  I  A  A  LL     + K+P + +TN G    + +   +S K  + + P Q++ SH+P +     +  R+L  G   V+ +A   GF++ V   D+ ++Y    A           E++R IP     +   K  +A+++F +P  W   +QII D + +     GML  NT   E       P +PI   N D+ W     L R G G F L +  LY +L+   L  YT  +GKP+++TY +A       E RL+ KI Q               +P   ++ +GDNP +D+ GA  Y
Sbjct:   26 RGKKPIAGASDALKLL----NRNKIPYILLTNGGGFSERARTEFISSKLDVDVSPLQIIQSHTPYKSLVNKY-SRILAVGTPSVRGVAEGYGFQDVVHQTDI-VRYNRDIAPFSGLSDEQVMEYSRDIP-----DLTTKKFDAVLVFNDPHDWAADIQIISDAINSEN---GML--NTLRNEKSGK---PSIPIYFSNQDLLWANPYKLNRFGQGAFRLLVRRLYLELNGEPLQDYT--LGKPTKLTYDFAHHVLIDWEKRLSGKIGQSVKQKLPLLGTKPSTSPFHAVFMVGDNPASDIIGAQNY 310

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Match: A0A0L8IEQ0 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22010257mg PE=4 SV=1)

HSP 1 Score: 384.8 bits (987), Expect = 8.139e-119
Identity = 210/427 (49.18%), Postives = 279/427 (65.34%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G++L+P AK+AF LL D +G++ VPA+FVTNAGN LR+EKA  LS+   +++ PDQVVMSHSPL+MF QFH K VLV GQGPV  IA  LGF    T+E L+  +P LD  +H RR  APCAFE Y   IEA+ILFGEP RWET+LQ+I D+LL++G P    NF          +PYPHLPILACNMD+ WMAEA +PR GHGCF+  LE LY+K++ R+L YT LIGKPSE+TYH+A+Y L+  AQ   GIN  ++ IYCIGDNP+TD+YG NLYNRYL     SR +++ ++A+     KV+QL +    + N+     + L+     +T+ T I+   S    +E++I     +K +SILV TGV   +     +  +    +   NHNHRDF    +LK P +V  +V EAV   F KEN+
Sbjct:   54 RGKNLLPSAKEAFKLLTDEYGRFIVPALFVTNAGNMLRQEKAKQLSKWLDVQVQPDQVVMSHSPLKMFRQFHDKHVLVSGQGPVLEIAKNLGFTKVTTIETLRQTFPLLDMVDHKRRQVAPCAFEKYFPKIEAVILFGEPVRWETNLQLITDVLLSDGLP----NFVP------REIPYPHLPILACNMDLLWMAEACIPRFGHGCFMHCLECLYQKVTGRELKYTALIGKPSEITYHHADYLLSLQAQSI-GING-VQTIYCIGDNPETDIYGGNLYNRYLH----SRSAKQRKQAK-----KVQQLANTTNSSINSDMSSVDELM-----DTEDTVIDLMSSGT--DESII---LTDKSVSILVCTGVYTTD-----SDFVTYGGKEISNHNHRDFVLDSELKKPTYVTQNVLEAVKLVFEKENY 444

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Match: A0A3P9CMD5 (Haloacid dehalogenase like hydrolase domain containing 5 OS=Maylandia zebra OX=106582 PE=4 SV=1)

HSP 1 Score: 356.681 bits (914), Expect = 2.380e-108
Identity = 192/427 (44.96%), Postives = 258/427 (60.42%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G++ IP AKQ F  L+DR GK+KVP VFVTNAGN +R+ KA  LS   ++++ PDQV++SHSPLRMFTQFHK RVLV GQGPV+ +A  LGF++ VT++ L+  YP LD  +HNRR           +PI+A++LFGEP RWET+LQ+I+D+LLT G P              S   YPH+P+LACNMD+ WMAEA  PR GHG FL+ LESLY+K++  KL Y  LIGKPS VTY+YAE  + + A+   G N P+K +Y IGDNP  D+YGANLYNRYL++ + ++   + + A  SI           P A ++             P+  S       +++ G   V++    E C SILV TGV   +    ++   K +T+  + H HRDF   P L  P  V H V EAV   F +E +
Sbjct:   54 RGKTPIPAAKQCFKNLVDRSGKYKVPVVFVTNAGNCMRQTKAEHLSHLLEVEVSPDQVMLSHSPLRMFTQFHKMRVLVSGQGPVEEVAHNLGFQDVVTIDVLREAYPVLDVVDHNRRPKDVVPPTKGLRPIDAVVLFGEPIRWETNLQLIVDVLLTGGNPGSTW----------SSAHYPHIPVLACNMDLLWMAEAWNPRFGHGMFLVCLESLYKKVTGYKLKYEALIGKPSVVTYNYAELLIRQQAERL-GWNTPVKRVYAIGDNPMADIYGANLYNRYLQSSRHTKAQMQAQSAGGSID----------PSAVDD------------TPKMTS-------AELGGASRVVERDLPEGCSSILVCTGVYSKDQQELLSDPTKTVTEQRIFHGHRDFRFDPSLTQPSFVVHDVKEAVELVFKQEGW 440

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Match: A0A3P8WBY6 (Haloacid dehalogenase like hydrolase domain containing 5 OS=Cynoglossus semilaevis OX=244447 PE=4 SV=1)

HSP 1 Score: 356.295 bits (913), Expect = 4.499e-108
Identity = 195/427 (45.67%), Postives = 254/427 (59.48%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR+ IP AKQ F  L+D  GK+KVP VFVTNAGN +R+ KA  LS   ++++ PDQVV+SHSPLRMFTQFHK  VLV GQGPV+ +A  LGF+N VT++ L+  YP LD  +HNRR            PI+A+ILFGEP RWET+LQ+I D+LLTNG P              S   YPH+P+LACNMD+ WMAEA  PR GHG F++ LESLY+K++  +L Y  LIGKPS VTY+YAE  + + A+   G   P+K +Y IGDNP  D+YGANLYN YL+A  G++     +KA+   G  VR   H +  A N++    E                   S + G+E  +     EKC SILV TGV   +    ++   + +T+  + H HRDF   P L  P  V   V EAV   F +E +
Sbjct:   56 RGRTPIPAAKQCFRNLVDSSGKYKVPVVFVTNAGNCMRQTKAEHLSHLLEVEVSPDQVVLSHSPLRMFTQFHKMCVLVSGQGPVEEVAHNLGFQNVVTIDKLREAYPVLDVVDHNRRPKGSIPPTKALPPIDAVILFGEPIRWETNLQLITDVLLTNGNPGSTW----------SSAQYPHIPVLACNMDLLWMAEAKNPRFGHGMFVVCLESLYKKITGHELKYEALIGKPSVVTYNYAELLIRQQAEKL-GWTTPVKRLYAIGDNPMADIYGANLYNHYLQASHGAK----GKKAKSGRGGVVR--THSLTEADNSERLSAE---------------PGGASAVFGSEEEL----PEKCHSILVCTGVYSRDQEELLSDTTQTVTEQQIFHGHRDFHFDPSLTQPSFVVQDVKEAVEMVFQQEGW 446

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Match: A0A3B4H2U9 (Haloacid dehalogenase like hydrolase domain containing 5 OS=Pundamilia nyererei OX=303518 PE=4 SV=1)

HSP 1 Score: 355.14 bits (910), Expect = 8.796e-108
Identity = 191/427 (44.73%), Postives = 258/427 (60.42%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G++ IP AKQ F  L+DR GK+KVP VFVTNAGN +R+ KA  LS   ++++ PDQV++SHSPLRMFTQFHK RVLV GQGPV+ +A  LGF++ VT++ L+  YP LD  +HNRR           +PI+A++LFGEP RWET+LQ+I+D+LLT G P              S   YPH+P+LACNMD+ WMAEA  PR GHG FL+ LESLY+K++  +L Y  LIGKPS VTY+YAE  + + A+   G N P+K +Y IGDNP  D+YGANLYNRYL++ + ++   + + A  SI           P A ++             P+  S       +++ G   V++    E C SILV TGV   +    ++   K +T+  + H HRDF   P L  P  V H V EAV   F +E +
Sbjct:   54 RGKTPIPAAKQCFKNLVDRSGKYKVPVVFVTNAGNCMRQTKAEHLSHLLEVEVSPDQVMLSHSPLRMFTQFHKMRVLVSGQGPVEEVAHNLGFQDVVTIDVLREAYPVLDVVDHNRRPKDVVPPTKGLRPIDAVVLFGEPIRWETNLQLIVDVLLTGGNPGSTW----------SSAHYPHIPVLACNMDLLWMAEAWNPRFGHGMFLVCLESLYKKVTGYELKYEALIGKPSVVTYNYAELLIRQQAERL-GWNTPVKRVYAIGDNPMADIYGANLYNRYLQSSRHTKAQMQAQSAGGSID----------PSAVDD------------TPKMTS-------AELGGASGVVERDLPEGCSSILVCTGVYSKDQQELLSDPTKTVTEQRIFHGHRDFRFDPSLTQPSFVVHDVKEAVELVFKQEGW 440

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Match: A0A3P8NLL9 (Haloacid dehalogenase like hydrolase domain containing 5 OS=Astatotilapia calliptera OX=8154 PE=4 SV=1)

HSP 1 Score: 353.984 bits (907), Expect = 2.846e-107
Identity = 191/427 (44.73%), Postives = 257/427 (60.19%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G++ IP AKQ F  L+D  GK+KVP VFVTNAGN +R+ KA  LS   ++++ PDQV++SHSPLRMFTQFHK RVLV GQGPV+ +A  LGF++ VT++ L+  YP LD  +HNRR           +PI+A++LFGEP RWET+LQ+I+D+LLT G P              S   YPH+P+LACNMD+ WMAEA  PR GHG FL+ LESLY+K++  KL Y  LIGKPS VTY+YAE  + + A+   G N P+K +Y IGDNP  D+YGANLYNRYL++ + ++   + + A  SI           P A ++             P+  S       +++ G   V++    E C SILV TGV   +    ++   K +T+  + H HRDF   P L  P  V H V EAV   F +E +
Sbjct:   58 RGKTPIPAAKQCFKNLVDHSGKYKVPVVFVTNAGNCMRQTKAEHLSHLLEVEVSPDQVMLSHSPLRMFTQFHKMRVLVSGQGPVEEVAHNLGFQDVVTIDVLREAYPVLDVVDHNRRPKDVVPPTKGLRPIDAVVLFGEPIRWETNLQLIVDVLLTGGNPGSTW----------SSAHYPHIPVLACNMDLLWMAEAWNPRFGHGMFLVCLESLYKKVTGYKLKYEALIGKPSVVTYNYAELLIRQQAERL-GWNTPVKRVYAIGDNPMADIYGANLYNRYLQSSRHTKAQMQAQSAGGSID----------PSAVDD------------TPKMTS-------AELGGASRVVERDLPEGCSSILVCTGVYSKDQQELLSDPTKTVTEQRIFHGHRDFRFDPSLTQPSFVVHDVKEAVELVFKQEGW 444

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Cavefish
Match: hdhd5 (haloacid dehalogenase-like hydrolase domain-containing 5 [Source:NCBI gene;Acc:103034889])

HSP 1 Score: 340.502 bits (872), Expect = 1.193e-105
Identity = 193/434 (44.47%), Postives = 257/434 (59.22%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRR----IPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHY--IPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLI--KMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKEN 1465
            +GR+ IP AKQ F  L+D +GK+KVP VFVTNAGN +R+ KA  LS   ++++ PDQV++SHSPLR+FTQFH+  VLV GQGP+  +A  LGF+N VT++ L+  YP LD  +HNRR    +P+P         IEA++LFGEP RWET+LQ+I+D+LLTNG+P            PV+ + YPH+P+LACNMD+ WMAEA  PR GHG FL+ LESLY+K++   L Y  LIGKPS VTY+YAE  + + A+   G   P++ +Y IGDNP  D+YGANLYNRYL   Q +R +    +A+  I  +V     Y  +  AKN+   +     E+ +P                          E C SILV TGV       D   L   + +T+  + H HRDF   P L  P  V H V EAV   F +E+
Sbjct:   58 RGRTPIPAAKQCFRKLVDGNGKYKVPVVFVTNAGNSMRQTKAEQLSHLLEVEVSPDQVMLSHSPLRVFTQFHEMCVLVSGQGPILEVAQNLGFQNVVTIDMLRKAYPLLDVVDHNRRPKNVVPSPKELPQ----IEAVVLFGEPIRWETNLQLIMDVLLTNGRP----------GNPVTSLHYPHIPVLACNMDLLWMAEAKNPRFGHGMFLVCLESLYKKITGHDLQYEALIGKPSVVTYNYAELLIRQQAESL-GWTEPVRRLYAIGDNPMADIYGANLYNRYL---QSTRCARAQVQAQGGIAGQVAGDVQYETVDDAKNSGKVMVGGSYEHCLP--------------------------EGCSSILVCTGVYS----RDQEDLAPDQTVTEQRIFHGHRDFRFDPSLIQPRFVVHDVLEAVELVFQQES 443

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Cavefish
Match: zgc:77375 (haloacid dehalogenase-like hydrolase domain-containing 5 [Source:NCBI gene;Acc:103034476])

HSP 1 Score: 320.857 bits (821), Expect = 1.935e-98
Identity = 186/429 (43.36%), Postives = 248/429 (57.81%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINN--PMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR+ IP AK+AF  L+D  G+  VP VFVTNAGN LR++KA  LS    + I  DQV+MSHSPL+MF +FH+K VLV GQGPV  IA  +GF N V+++ L+  +P LD  +HNRR   P +       +EA+ILFGEP RWET+LQ+I+D+LLT+G        N +     SH    HLP+LACNMD+ WMAEA  PR GHG F++ LE++Y+K++ + L Y  L+GKPSE+TYHYAEY + + A +  G N PI+ +Y IGDN  TD+YGANLYNRYLE +   + ++ + +   + G                             P ++    ES +      E+ + +  A  C SILV TGV   +N  P D +  IK      V H HRDF   P L  PG+V   V  AV   F  E F
Sbjct:   58 RGRTPIPAAKKAFQKLVDSKGQLVVPVVFVTNAGNCLRQKKADQLSHILGIPISQDQVMMSHSPLKMFRKFHEKCVLVSGQGPVLDIAKNVGFTNVVSIDMLRESFPLLDMVDHNRRPKLPSSPIVNLPKVEAVILFGEPIRWETNLQLIIDVLLTSG--------NLSNVYETSH--SSHLPLLACNMDLMWMAEAQAPRFGHGTFMVCLENIYKKITGQDLKYEALMGKPSELTYHYAEYLIREQAAE-RGWNRPIRSLYAIGDNLMTDIYGANLYNRYLEERLARKSTKAVAQVVAATGAPT--------------------------PVSQELDTESIW------ESELASPSATSCKSILVCTGVYNPHNEVPKDASQCIK----ETVFHGHRDFRFDPALVEPGNVVQDVDAAVELIFKIEKF 439

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007931.1 (pep scaffold:Pmarinus_7.0:GL478704:2:13683:-1 gene:ENSPMAG00000007172.1 transcript:ENSPMAT00000007931.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 143.665 bits (361), Expect = 1.698e-39
Identity = 77/151 (50.99%), Postives = 97/151 (64.24%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKP----IEAIILFGEPSRWETSL 628
            +GR+ IP A+ AF  LLD  G  +VP VFVTNAGN LR+ KA  LS+   + I  +QV++SHSPLRMF Q+H K VLV GQGPV+ IA  LGF   VT++ L+  +P LD  +  RR P      T + P      AII+FGEP RWET+L
Sbjct:   34 RGRTPIPAARDAFRKLLDASGALRVPVVFVTNAGNCLRQAKAAQLSDVLGVPISQEQVMLSHSPLRMFEQYHHKHVLVSGQGPVEDIAKNLGFTQIVTIDMLREAFPLLDMVDQTRR-PKELPTTTPDFPKIDATTAIIVFGEPIRWETNL 183

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Yeast
Match: YKR070W_mRNA (Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001778])

HSP 1 Score: 107.071 bits (266), Expect = 2.666e-25
Identity = 87/306 (28.43%), Postives = 139/306 (45.42%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDA----------CEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLH-YTGLIGKPSEVTYHYA-------EYRLN-KIAQDFHG---------INNPIKHIYCIGDNPQTDVYGANLY 1021
            +G+  I  A  A  LL     + K+P + +TN G    + +   +S K  + + P Q++ SH+P +     +  R+L  G   V+ +A   GF++ V   D+ ++Y    A           E++R IP     +   K  +A+++F +P  W   +QII D + +     GML  NT   E       P +PI   N D+ W     L R G G F L +  LY +L+   L  YT  +GKP+++TY +A       E RL+ KI Q               +P   ++ +GDNP +D+ GA  Y
Sbjct:   26 RGKKPIAGASDALKLL----NRNKIPYILLTNGGGFSERARTEFISSKLDVDVSPLQIIQSHTPYKSLVNKY-SRILAVGTPSVRGVAEGYGFQDVVHQTDI-VRYNRDIAPFSGLSDEQVMEYSRDIP-----DLTTKKFDAVLVFNDPHDWAADIQIISDAINSEN---GML--NTLRNEKSGK---PSIPIYFSNQDLLWANPYKLNRFGQGAFRLLVRRLYLELNGEPLQDYT--LGKPTKLTYDFAHHVLIDWEKRLSGKIGQSVKQKLPLLGTKPSTSPFHAVFMVGDNPASDIIGAQNY 310

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
Match: hdhd5 (haloacid dehalogenase like hydrolase domain containing 5 [Source:NCBI gene;Acc:101167363])

HSP 1 Score: 317.005 bits (811), Expect = 3.700e-97
Identity = 179/426 (42.02%), Postives = 244/426 (57.28%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKEN 1465
            +G + IP AK+ F  L+DR G++KVP VFVTNAGN +R  KA  LS+  ++++ PDQVV+SHSPLR+F++FH+K VLV GQGPV+ +A  LGF + VT++ L+  YP LD  + +RR           +PIEA++LFGEP RWET+LQ+I+D+LLTNG P            P S    PH+P+LACNMD+ WMAEA  PR GHG FL+ LE+LY+K++ R+L Y  LIGKPS VTY+YAE  + + A+   G + P+K +Y IGDN  +DVYGANLYN+YL+A++  R          ++                                  S       + + G+E    A   E C SILV TGV   +         +  T+ +V H HRDF   P L  P  + H V EA+   F +E 
Sbjct:   52 RGGTPIPAAKRVFRKLVDRRGRYKVPVVFVTNAGNCMRDTKAEHLSQLLEVEVSPDQVVLSHSPLRVFSKFHQKHVLVSGQGPVEDVAHNLGFEDVVTMDTLREAYPVLDMVDQSRRPKDSVPPTRGLRPIEAVVLFGEPVRWETNLQLIVDVLLTNGDPD----------RPWSTARQPHIPVLACNMDLLWMAEAKNPRFGHGMFLVCLENLYQKVTGRQLQYEALIGKPSVVTYNYAELLIRQQAEKL-GWSGPVKRLYAIGDNLMSDVYGANLYNQYLQARRQRRADGGGPAGAANV----------------------------------SPAELGGAADVNGSE----AELPEACSSILVCTGVYSRD-----QQEARPGTERHVYHGHRDFRFDPGLTQPSFLVHDVKEALELVFQQEG 423

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
Match: zgc:77375 (haloacid dehalogenase-like hydrolase domain-containing 5 [Source:NCBI gene;Acc:101172977])

HSP 1 Score: 308.145 bits (788), Expect = 4.284e-94
Identity = 185/427 (43.33%), Postives = 241/427 (56.44%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR  IP AK+ F  L++  G++ VP VFVTNAGN LR+ KA  LS    + I  +QVVMSHSPLRM  +FH K VLV GQGPV  IA  +GF+N ++++ L+  YP LD  +HNRR   P         +EA++LFGEP RWET+LQ+I+D+LLTNG P G+                PHLP+LACNMD+ WMAEA  PR GHG FL+ LE++++K++ R+L Y  L+GKPSE+TYH+AE+ +   A +      PI  +Y IGDN  TD+YGANLYNRYLE     R++ +  KA       V Q+      A       GE        E   +  ESE          +    A  C SILV TGV   N+ +D+ S      +  V H HRDF   P L  P ++   V EAV   F  E F
Sbjct:   34 RGRIPIPAAKKTFEKLVNSQGQFVVPVVFVTNAGNCLRQTKADQLSHLLGVPITQEQVVMSHSPLRMLRKFHDKCVLVSGQGPVLDIAKNVGFKNVISIDMLRESYPLLDMVDHNRRPKLPTNPVINLPKVEAVVLFGEPIRWETNLQLIIDVLLTNGNPSGIHQSQV----------MPHLPLLACNMDLMWMAEANSPRFGHGTFLVCLENIFKKITGRELKYEALMGKPSELTYHFAEFLIRSQALE-RQWKLPITTLYAIGDNLMTDIYGANLYNRYLE----ERVARKNPKA-------VAQMAAVTGSAST---LPGE--------EESDSLWESE----------LALPSATSCKSILVCTGV--YNHSVDVPSDPHRCIKQTVFHGHRDFRFEPALVEPDYITEDVAEAVDLIFKHEKF 415

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
Match: zgc:77375 (haloacid dehalogenase-like hydrolase domain-containing 5 [Source:NCBI gene;Acc:101172977])

HSP 1 Score: 308.531 bits (789), Expect = 7.799e-94
Identity = 185/427 (43.33%), Postives = 241/427 (56.44%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +GR  IP AK+ F  L++  G++ VP VFVTNAGN LR+ KA  LS    + I  +QVVMSHSPLRM  +FH K VLV GQGPV  IA  +GF+N ++++ L+  YP LD  +HNRR   P         +EA++LFGEP RWET+LQ+I+D+LLTNG P G+                PHLP+LACNMD+ WMAEA  PR GHG FL+ LE++++K++ R+L Y  L+GKPSE+TYH+AE+ +   A +      PI  +Y IGDN  TD+YGANLYNRYLE     R++ +  KA       V Q+      A       GE        E   +  ESE          +    A  C SILV TGV   N+ +D+ S      +  V H HRDF   P L  P ++   V EAV   F  E F
Sbjct:   59 RGRIPIPAAKKTFEKLVNSQGQFVVPVVFVTNAGNCLRQTKADQLSHLLGVPITQEQVVMSHSPLRMLRKFHDKCVLVSGQGPVLDIAKNVGFKNVISIDMLRESYPLLDMVDHNRRPKLPTNPVINLPKVEAVVLFGEPIRWETNLQLIIDVLLTNGNPSGIHQSQV----------MPHLPLLACNMDLMWMAEANSPRFGHGTFLVCLENIFKKITGRELKYEALMGKPSELTYHFAEFLIRSQALE-RQWKLPITTLYAIGDNLMTDIYGANLYNRYLE----ERVARKNPKA-------VAQMAAVTGSAST---LPGE--------EESDSLWESE----------LALPSATSCKSILVCTGV--YNHSVDVPSDPHRCIKQTVFHGHRDFRFEPALVEPDYITEDVAEAVDLIFKHEKF 440

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
Match: ENSORLT00000011546.2 (haloacid dehalogenase-like hydrolase domain-containing 5 [Source:NCBI gene;Acc:101172237])

HSP 1 Score: 271.937 bits (694), Expect = 3.825e-81
Identity = 174/430 (40.47%), Postives = 220/430 (51.16%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYP--HLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPM--DINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKEN 1465
            +G ++IP A++A   L+D +  +  P +FVTNAG+  R  KA  LS    + + P+QVV+SHSPL +   FH K VLV GQGPV +IA  LGF+  VT+E L   +P LD  +HNRR  AP +       I+AIILFGEP RWET+LQ+++D+LLT G P              +H P P   LPILACN D+ WMAEAP PR GHG FLL LE++Y KL+ R+L Y  L+GKPS +TY YAE  L          N  +  IY +GDN  TDVYGANLYNRYL  Q  +  S          G K   L    P     Q  V                                   A +C SILV TGV   ++P+  D NS I  +    V H  RD      L  P  V   V  AV +   +E+
Sbjct:   32 RGGTVIPAARRALRKLVDENNNFLYPVIFVTNAGSCQRLHKARQLSHLLDIHVSPEQVVLSHSPLNIMKTFHNKCVLVSGQGPVTSIAQSLGFQKVVTIEQLSQHHPLLDMVDHNRRPTAPLSPLEDLPQIQAIILFGEPVRWETNLQLLVDVLLTEGSPGS------------AHDPQPPTQLPILACNTDLLWMAEAPSPRFGHGMFLLCLEAVYRKLTGRELQYEALLGKPSLLTYQYAERLLRT-----QNHNRKLSIIYAVGDNLMTDVYGANLYNRYLSQQPEAMKS----------GAKRVALGTGGPITMEEQEPVS----------------------------------ATECRSILVCTGVYNPHSPLPSDQNSSITEM----VFHGQRDLVLDRDLLEPSRVVEDVEAAVDFMLQQES 396

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BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Planmine SMEST
Match: SMESG000023294.1 (SMESG000023294.1)

HSP 1 Score: 909.827 bits (2350), Expect = 0.000e+0
Identity = 454/454 (100.00%), Postives = 454/454 (100.00%), Query Frame = 2

Query:  113 MFLFRKRFYSXXXXXXXXXXXXXXXKGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF 1474
            MFLFRKRFYSSISFGFFFDIDGVFVKGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF
Sbjct:    1 MFLFRKRFYSSISFGFFFDIDGVFVKGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENFGF 454

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Planmine SMEST
Match: SMESG000006859.1 (SMESG000006859.1)

HSP 1 Score: 254.988 bits (650), Expect = 7.546e-75
Identity = 162/428 (37.85%), Postives = 227/428 (53.04%), Query Frame = 2

Query:  188 KGRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEH-NRRIPAPCAFETYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGANLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGENLIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINNPMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKENF 1468
            +G + +  A   FN +    G+  VP  F+TNA + L   KAL + + F +KIHPDQV+ + SPL++FT +H K VL  GQ  ++ IA  LGF+  +T++ ++  YP LD  +H NRR  A    E    P+EAIIL GEP  WE+ LQ+I+D+L+TNG+P            P S  P  HLPILACNMD+ +MAEA LPR GHG FLL LE+LY+K++   L+YT +IGKPSE+T+ +AE+ ++ +A+   GI +PIK +Y  GDNP  D+ GANLYN YL+  +     +EI K       K+R                                     S+++  E       A++  SILV TGV + +             Q+  N+ HRDF    +L  P       YE +   F  ENF
Sbjct:   43 RGSTPLQCAIDMFNEVKTADGEPTVPMAFLTNACH-LSDTKALMIQKWFGIKIHPDQVIHAPSPLKVFTHWHNKCVLFVGQDDIQQIAYELGFKKVITLDQVKDAYPLLDMVDHSNRRNLAKGYEERKLDPVEAIILMGEPKNWESYLQLIIDLLVTNGKPD---------ISPES-FPEKHLPILACNMDLVFMAEAVLPRFGHGAFLLCLETLYQKITGHPLNYTAIIGKPSEITFRFAEHTISLVAKRM-GIQSPIKSLYFFGDNPAVDILGANLYNNYLKRFRRMSGGKEITKEERQ---KLR------------------------------VQASMSASRVVPEEAEFLPQTAKQIDSILVHTGVYKPDKD-------HKQKQNQPNYCHRDFTRASELDNPMIDVEDCYEGMQAIFRTENF 418

[Close]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Planmine SMEST
Match: SMESG000053967.1 (SMESG000053967.1)

HSP 1 Score: 181.415 bits (459), Expect = 1.447e-49
Identity = 102/285 (35.79%), Postives = 162/285 (56.84%), Query Frame = 2

Query:  191 GRSLIPEAKQAFNLLLDRHGKWKVPAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKRVLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFE-TYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVSHVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHYTGLIGKPSEVTYHYAEYRLNKIAQDFHGINN--PIKHIYCIGDNPQTDVYGANLYNRYLE 1036
            G   I  A++ F+ + +   K K+P  F+TN+ +    +    L++ F + +    ++ + +PLR+F   H KR+L  GQG +  I   L F N V +  +Q+ +P+LD  + ++R      +  T   PI+ +I+ GEP+ W++ LQII D+L+T+G           L  PV  +    LPI  CN+D  + AE+ + R G+G F+ +LE LY+K +   L Y+ +IGKPSE++Y YAE  LN I Q    INN   ++ IY IGDNP +D+ GANLY R+++
Sbjct:   36 GSHGIEGARKMFDTIKESF-KSKIPMAFLTNSCDSPEIKSDF-LNQMFDINLDKKSIIHAPAPLRLFKDLHNKRMLFVGQGNMTKIGQDLKFTNVVELAHIQIAHPNLDVIDKDKRRALKHGYSVTGIDPIDGVIIVGEPTDWQSYLQIITDLLVTHGD----------LSSPVD-MSSQRLPIYLCNLDFLYKAESSMLRFGNGAFIHSLEMLYKKYTGLDLKYSTVIGKPSEISYFYAEQVLNSINQQ---INNGTQLERIYMIGDNPASDILGANLYQRFID 304

The following BLAST results are available for this feature:

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Human
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Celegans
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Fly
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Zebrafish
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Xenopus
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Mouse
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Cavefish
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Sea Lamprey
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Yeast
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Nematostella
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Planmine SMEST

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3


Match Name	E-value	Identity	Description
HDHD5	2.944e-90	39.53	haloacid dehalogenase like hydrolase domain contai...	[more]
HDHD5	8.588e-90	39.53	haloacid dehalogenase like hydrolase domain contai...	[more]
HDHD5	1.279e-16	55.71	haloacid dehalogenase like hydrolase domain contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
H32C10.1	4.599e-74	34.79	pep chromosome:WBcel235:IV:5934346:5937497:1 gene:...	[more]
H32C10.1	6.574e-72	34.40	pep chromosome:WBcel235:IV:5934444:5937497:1 gene:...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hdhd5	3.216e-103	43.93	haloacid dehalogenase like hydrolase domain contai...	[more]
zgc:77375	3.684e-96	42.69	zgc:77375 [Source:ZFIN;Acc:ZDB-GENE-040426-1827]	[more]
hdhd5	2.927e-63	54.46	haloacid dehalogenase like hydrolase domain contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hdhd5	1.490e-94	52.61	haloacid dehalogenase like hydrolase domain contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Hdhd5	2.930e-90	39.25	haloacid dehalogenase like hydrolase domain contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q91WM2\|HDHD5_MOUSE	2.050e-89	39.25	Haloacid dehalogenase-like hydrolase domain-contai...	[more]
sp\|Q9BXW7\|HDHD5_HUMAN	4.124e-89	39.53	Haloacid dehalogenase-like hydrolase domain-contai...	[more]
sp\|O13899\|YF38_SCHPO	1.527e-24	29.46	Uncharacterized CDP-alcohol phosphatidyltransferas...	[more]
sp\|P36151\|YK50_YEAST	1.851e-23	28.43	Uncharacterized protein YKR070W OS=Saccharomyces c...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0L8IEQ0	8.139e-119	49.18	Uncharacterized protein OS=Octopus bimaculoides OX...	[more]
A0A3P9CMD5	2.380e-108	44.96	Haloacid dehalogenase like hydrolase domain contai...	[more]
A0A3P8WBY6	4.499e-108	45.67	Haloacid dehalogenase like hydrolase domain contai...	[more]
A0A3B4H2U9	8.796e-108	44.73	Haloacid dehalogenase like hydrolase domain contai...	[more]
A0A3P8NLL9	2.846e-107	44.73	Haloacid dehalogenase like hydrolase domain contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
hdhd5	1.193e-105	44.47	haloacid dehalogenase-like hydrolase domain-contai...	[more]
zgc:77375	1.935e-98	43.36	haloacid dehalogenase-like hydrolase domain-contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000007931.1	1.698e-39	50.99	pep scaffold:Pmarinus_7.0:GL478704:2:13683:-1 gene...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
YKR070W_mRNA	2.666e-25	28.43	Putative protein of unknown function; the authenti...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
hdhd5	3.700e-97	42.02	haloacid dehalogenase like hydrolase domain contai...	[more]
zgc:77375	4.284e-94	43.33	haloacid dehalogenase-like hydrolase domain-contai...	[more]
zgc:77375	7.799e-94	43.33	haloacid dehalogenase-like hydrolase domain-contai...	[more]
ENSORLT00000011546.2	3.825e-81	40.47	haloacid dehalogenase-like hydrolase domain-contai...	[more]

BLAST of haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000023294.1	0.000e+0	100.00	SMESG000023294.1	[more]
SMESG000006859.1	7.546e-75	37.85	SMESG000006859.1	[more]
SMESG000053967.1	1.447e-49	35.79	SMESG000053967.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30000009 ID=SMED30000009|Name=haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1|organism=Schmidtea mediterranea sexual|type=transcript|length=3477bp
TAAAGGTCATTAATCAGATCACTTTAAGAATTCTTTTAAAAATAGTAGAA
TTTATAAGTTATTATTTTTTTCAGATTATATACTATTTTTTGATGATTTA
TGTTTTATAAAAATGTTTTTATTTAGAAAACGTTTTTACTCTAGCATTTC
TTTTGGGTTTTTCTTTGATATTGATGGAGTATTTGTAAAAGGCAGAAGCT
TAATTCCTGAAGCCAAACAAGCTTTCAACTTATTATTAGATCGTCATGGA
AAATGGAAAGTCCCAGCAGTGTTTGTTACAAATGCAGGCAATAAACTTCG
AAAAGAAAAAGCTTTAGATTTATCAGAAAAATTCAAACTGAAAATTCACC
CAGATCAAGTTGTAATGTCTCACAGCCCTCTTCGGATGTTTACTCAATTT
CATAAGAAACGCGTATTAGTATGCGGACAAGGTCCAGTAAAAACAATCGC
AACAATGTTAGGATTTCGAAACGCTGTTACCGTAGAAGATTTACAGCTTC
AGTATCCACATTTGGACGCTTGTGAACATAACCGAAGAATACCAGCTCCA
TGTGCATTTGAAACATATAACAAACCCATTGAAGCGATAATATTGTTTGG
AGAGCCCAGTAGATGGGAGACGAGTTTGCAAATTATATTAGATATGTTGT
TAACCAATGGACAACCTTATGGGATGTTGAATTTTAACACGGCTCTCTGT
GAACCAGTTTCACATGTCCCATATCCTCACTTGCCTATTTTAGCATGTAA
TATGGACATGCAATGGATGGCAGAAGCCCCACTACCTCGACTGGGTCACG
GTTGTTTTTTACTTGCCCTCGAATCTCTCTACGAAAAATTGAGTAGTAGA
AAGTTGCATTACACTGGCCTTATTGGGAAACCCAGTGAAGTGACTTATCA
TTATGCTGAATACCGATTAAACAAAATAGCTCAAGATTTTCATGGCATTA
ATAACCCCATCAAACATATCTATTGTATCGGAGATAACCCCCAAACTGAC
GTATATGGTGCAAACCTTTATAACCGATACCTGGAAGCTCAACAAGGCAG
TCGAATTTCAGAAGAAATTGAAAAAGCTCGCCATTCAATTGGTGACAAAG
TCAGACAATTGAATCACTACATTCCGCGGGCTAAAAACAATCAATATTTT
GTCGGTGAAAATCTGATAGAAAATCTGATTCCGGAAACGAAGAGCACCCA
TATCGAATCTGAATACTCGCAAATTATTGGCAACGAAACTGTTATTAAAG
CTGGATTTGCTGAGAAATGCATATCCATTCTAGTACTAACTGGGGTTATT
CGGATTAACAACCCGATGGATATAAATTCATTGATAAAAATGATAACCCA
AAGCAATGTTAATCATAACCACAGAGACTTCCCTGATTATCCACAATTGA
AGGTTCCTGGTCACGTTGCTCATAGTGTCTATGAGGCCGTTCTCTATGCT
TTTAACAAGGAAAACTTCGGATTTTGAAACCAATTGTCCTATTTTATTGA
TCTATATTTACATATACATACATTATACATATTCAATACAATTTACGATC
TTGTTTATCACACAGAACAATAAATAAATCCAATCAGATCCGATCCGATC
AAAAAACCAATTGAAATGAGATTCAATGGAACTAGTGTATTTTCTTTGTC
TTATCGATTATTTTCTTATTGGCTCGTTTTCATTGGTTGCCGGGCCGTGC
CGGTCCGGTGGTGCACATCAATGGGATTTCTGTATTTGTTATTATTGATC
TAGACATTTTTGACTCATATTTTCCGATTGAATATTTTTCAGCTAATAGT
CGTTCGGGATTTGTTTAGTAATCGATATATCGAGAAGGAGGGAGCGAGAG
GGAGGCAGGTAGGATGAGAGAGTAACTGTGATTACGGCATCTCTTATTTT
ATTAATTGTTTTAGTTGATATACCTTTTATTGTTTTCTTTTTACTACTAG
AATATATATTTACAAATCGCAGGGCTTTTTACACCGGATTGATCAGCCAA
TGAAATCAATTGCACCGCGTTATTCGTGTAAATGCAATAAATCGATATTC
AAATTTTATAGCTCACATGAGTTATCGTGCATTCTAATGTTCCCCTAGCA
ATAACTCATGAGTATTTTTACTTTTACAACTAAGGCAAAAAATATGAATT
CGTTTTGGATTTCTTATGTTTCTCTGCAAAATTATTTCAGCAATTTGATT
GTCATTTTGAAGCATGTCTGCAATTGGTGAAATCCCTGGCAACCAGTCAT
ACGCGTCGGTTAGAACCTCATTTTGAGAGTCCGTGGGATTGAAAAGGAAT
TCGGTTATCTGCTAAAGGTTTTTTGGTGTCTTTAATAGTTTAATGTTTGA
AAATTCAATCGAGTCAGTTAAGTTCGTTTATTGGTGTTATTCTAGGTAGC
TTACAAAGGCGAACTGTAAACCGGTTCGAGATCTGGAATAGTAGATTTCA
GTAAATCAAAGCATTAAGAATTTTTTTCAATAAATGATTTTACCTTAAGC
CATTGAGTTTATATAAGCGTTTATCCACGAGATTTTCTACTTTCTGTTGG
ACTATCCTTAGCCTTGCTCATTGAGTACTCAAAGATCTCCGTGTAATGAA
ACGTACGTGTTTGAGAAAGATATTTTATCATGCTTATAGTTTTTATAAGA
ATAGAAATGAGTTTATTAGCAATCGTCATTTTACGGTTTAGATACAATGA
ACGTAATGAATCAAGTGTTGCACCCCCTGACATCACTGGTTTCGCCACAT
TTTATGAAATTATTTCCGCAAGAGTTTGGCCATCTAATATCTCAGAACGA
GAATGCTTTAGCTGCAACTTCGAGAATTTAAAAAACTAATATAAAGAAAG
CAAACCAAATAATAGTTTTAATTTAATAAAAAAGTTATTGTTTTCTTCAA
ATAATCTAATCAAAACAAAATGCTTTCCTAAATGAAATAACTAAATACAT
CGCTTTAGATAAATGTTAGCTACTCAAATTACTTTTTTTACAAAGAATTG
CTATAACTTGCCACTATCTTGCATATAAAATCCAAAAAGAAACCACGATT
CGCACAATAGTGGAGCATTCATGGTATGGGTTAGGTTGAGGAAATGACGA
ACTTTTAACAAAACAAAGTTTCAAATTCTTAAAATATATGGTGACAATAG
AAAGAATGATCATAGGTACGCTGAAGAGGTTTTCACATATGATTGCCCCG
ACTTGCCAAAAATAACACATTTAGAATTTTTAATTCTTACGTTTTATTTC
CGTAACTTTGTTTTGACATGCAAATTATGTCTTTGTTTATATATAATTAA
TAAATTTCAGCCCTTACAAAAACAGTTCTAAATATTATCATGTGAATAAA
TCCAAATATATCGTTAAATGATATAGTTGAGGTTGTGCAGATTTAAAATT
ATTTGGCAAAATTTGAGAAATGAAGTAATTAATTTAAGAAATGATAACTG
GTAAAAATCAATATTTTTTGGGGGAAA

protein sequence of SMED30000009-orf-1

>SMED30000009-orf-1 ID=SMED30000009-orf-1|Name=SMED30000009-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=455bp
MFLFRKRFYSSISFGFFFDIDGVFVKGRSLIPEAKQAFNLLLDRHGKWKV
PAVFVTNAGNKLRKEKALDLSEKFKLKIHPDQVVMSHSPLRMFTQFHKKR
VLVCGQGPVKTIATMLGFRNAVTVEDLQLQYPHLDACEHNRRIPAPCAFE
TYNKPIEAIILFGEPSRWETSLQIILDMLLTNGQPYGMLNFNTALCEPVS
HVPYPHLPILACNMDMQWMAEAPLPRLGHGCFLLALESLYEKLSSRKLHY
TGLIGKPSEVTYHYAEYRLNKIAQDFHGINNPIKHIYCIGDNPQTDVYGA
NLYNRYLEAQQGSRISEEIEKARHSIGDKVRQLNHYIPRAKNNQYFVGEN
LIENLIPETKSTHIESEYSQIIGNETVIKAGFAEKCISILVLTGVIRINN
PMDINSLIKMITQSNVNHNHRDFPDYPQLKVPGHVAHSVYEAVLYAFNKE
NFGF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0016787	hydrolase activity
GO:0003674	molecular_function

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR006353	HAD-SF_hydro_IIA_CECR5
IPR029621	CECR5
IPR036412	HAD-like_sf
IPR023214	HAD_sf
IPR006357	HAD-SF_hydro_IIA

Vocabulary: **cellular component**
Term	Definition
GO:0005739	mitochondrion

Vocabulary: **biological process**
Term	Definition
GO:0046474	glycerophospholipid biosynthetic process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006357	HAD-superfamily hydrolase, subfamily IIA	PFAM	PF13344	Hydrolase_6	coord: 16..118 e-value: 2.7E-19 score: 69.2
IPR006357	HAD-superfamily hydrolase, subfamily IIA	TIGRFAM	TIGR01460	TIGR01460	coord: 16..301 e-value: 6.9E-51 score: 171.4
IPR023214	HAD superfamily	GENE3D	G3DSA:3.40.50.1000		coord: 16..304 e-value: 1.2E-66 score: 226.9
IPR023214	HAD superfamily	GENE3D	G3DSA:3.40.50.1000		coord: 86..254 e-value: 1.2E-66 score: 226.9
IPR006353	HAD-superfamily hydrolase, subfamily IIA, CECR5	TIGRFAM	TIGR01456	TIGR01456	coord: 14..305 e-value: 1.3E-80 score: 268.6
None	No IPR available	PFAM	PF13242	Hydrolase_like	coord: 254..302 e-value: 3.4E-6 score: 27.0
None	No IPR available	PANTHER	PTHR14269	CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED	coord: 11..452
IPR029621	Cat eye syndrome critical region protein 5	PANTHER	PTHR14269:SF17	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING 5	coord: 11..452
IPR036412	HAD-like superfamily	SUPERFAMILY	SSF56784	HAD-like	coord: 16..303

Main menu

haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

blazegraph-runner